NDP Gene

Aliases
for NDP gene

Previous GC identifers: GC0XM041819 GC0XM042068 GC0XM042634 GC0XM042854 GC0XM043564 GC0XM043692 GC0XM041537

Summaries
for NDP gene

Genomic Views
for NDP gene

RefSeq DNA sequence:

NC_000023.10  NC_018934.1  NT_079573.4  

SwitchGear Promoter luciferase reporter plasmid: NDP promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDP

NDP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM043808:  view genomic region     (about GC identifiers)

Proteins
for NDP gene

Explore the universe of human proteins at neXtProt for NDP: NX_Q00604

NDP Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NDP (Norrin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NDP OriGene Custom Protein Services for NDP
	GenScript Custom Purified and Recombinant Proteins Services for NDP
	Novus Biologicals NDP Proteins Novus Biologicals NDP Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NDP

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for NDP (Norrin)
	OriGene Antibodies: NDP OriGene Custom Antibody Services for NDP
	GenScript Superior Antibodies for NDP
	Novus Biologicals NDP Antibodies
	Search for Antibodies for NDP at Abcam
	Uscn Antibodies for NDP
	ThermoFisher Antibody for NDP

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NDP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NDP

Protein Domains /
Families
for NDP gene

ProtoNet protein and cluster: Q00604

Function
for NDP gene

miRNA Products:		OriGene 3'-UTR Clone: NDP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDP
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NDP (see all 20):
		hsa-miR-148b hsa-miR-15a hsa-miR-515-5p hsa-miR-223 hsa-miR-424 hsa-miR-532-5p hsa-miR-195 hsa-miR-15b
		SwitchGear 3'UTR luciferase reporter plasmid: NDP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDP (see all 4) OriGene shRNA RFP: NDP OriGene siRNA: NDP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDP

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NDP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDP (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NDP (NM_000266)
		Sino Biological Human cDNA Clone for NDP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NDP
		Search LifeMap BioReagents cell lines for NDP

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDP

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Ndp)

Pathways & Interactions
for NDP gene

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

Drugs & Compounds
for NDP gene

Transcripts
for NDP gene

Expression
for NDP gene

NDP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCAAAAT

Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	PureStem™ progenitor W8 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDP

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDP

Orthologs
for NDP gene

Paralogs
for NDP gene

Genomic Variants
for NDP gene

10/358 NCBI SNPs in NDP are shown (see all 358)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs289336841,2	C	pathogenic	43809077(-)	ACATCC/TTCTCC	2	L F	mis1 ese3		2		NA	4
rs1048948781,2	C	pathogenic	43809086(-)	CCTACC/TGGTAC	2	R W	mis1		0	--	--	--	--
rs1048948761,2	C	pathogenic	43809119(-)	TGCGAG/TGCTCA	2	G C	mis1		0	--	--	--	--
rs1048948831,2	C	pathogenic	43809145(-)	GACTTC/TCAAGC	2	S F	mis1		0	--	--	--	--
rs1048948771,2	C	pathogenic	43809159(-)	TGCTGC/GCGGCC	2	C W	mis1		0	--	--	--	--
rs1048948711,2	C	pathogenic	43809160(-)	CTGCTA/GCCGGC	2	Y C	mis1		0	--	--	--	--
rs1048948671,2	C	pathogenic	43809178(-)	CTTCCC/GTTCCT	2	P R	mis1		0	--	--	--	--
rs1048948681,2	C	pathogenic	43809223(-)	ACGCTC/GCGAGC	2	S C	mis1		0	--	--	--	--
rs1048948821,2	C	pathogenic	43809229(-)	GGCGTA/CACGCT	2	* S	stg1		0	--	--	--	--
rs1048948721,2	C	pathogenic	43809241(-)	GCACTC/GCAGCC	2	S C	mis1		0	--	--	--	--

HapMap Linkage Disequilibrium report for NDP (43808022 - 43832921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NDP: --
Human Gene Mutation Database (HGMD): NDP

Locus Specific Mutation Databases (LSDB): NDP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDP

DNA2.0 Custom Variant and Variant Library Synthesis for NDP

Disorders / Diseases
for NDP gene

20/26 diseases for NDP

10 Novoseek disease relationships for NDP gene    About this table

Publications
for NDP gene

PubMed articles for NDP gene, integrated from 9 sources (see all 117): (articles sorted by number of sources associating them with NDP)

Utopia: connect your pdf to the dynamic world of online information

1. A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy. (PubMed id 8252044)^{1, 2, 3, 9} Chen Z.-Y.... Craig I.W. (1993)
2. Ocular findings associated with a Cys39Arg mutation in the Norrie disease gene. (PubMed id 7993212)^{1, 2, 4} Joos K.M.... Stone E.M. (1994)
3. Norrie disease protein (norrin) forms disulfide-linked oligomers associated with the extracellular matrix. (PubMed id 9407136)^{1, 2, 9} Perez-Vilar J. and Hill R.L. (1997)
4. Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis. (PubMed id 10484772)^{1, 2, 9} Black G.C.M.... McLeod D. (1999)
5. Norrie disease gene sequence variants in an ethnically diverse population with retinopathy of prematurity. (PubMed id 16052165)^{1, 4, 9} Hutcheson K.A....Young T.L. (2005)
6. Retinal phenotype-genotype correlation of pediatric patients expressing mutations in the Norrie disease gene. (PubMed id 17296899)^{1, 2, 9} Wu W.C....Dailey W. (2007)
7. Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure. (PubMed id 8298646)^{1, 2, 9} Meitinger T....Murken J. (1993)
8. A novel missense mutation in the NDP gene in a child with Norrie disease and severe neurological involvement including infantile spasms. (PubMed id 17334993)^{1, 2, 9} Lev D....Watemberg N. (2007)
9. Novel mutations in Norrie disease gene in Japanese patients with Norrie disease and familial exudative vitreoretinopathy. (PubMed id 17325173)^{1, 2, 9} Kondo H....Hayashi K. (2007)
10. X-linked exudative vitreoretinopathy caused by an arginine to leucine substitution (R121L) in the Norrie disease protein. (PubMed id 8946107)^{1, 2, 9} Johnson K....Ferrell R.E. (1996)

External Searches for NDP gene

Genome Databases showing NDP gene

Other Databases showing NDP gene

Specialized Databases showing NDP gene

Products
for NDP gene