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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDOR1 Gene

protein-coding   GIFtS: 54
GCID: GC09P140100

NADPH dependent diflavin oxidoreductase 1
 Explore 13 diseases affiliated with
NDOR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDOR1    

Aliases
for NDOR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NADPH Dependent Diflavin Oxidoreductase 11 2     NADPH-Dependent Diflavin Oxidoreductase 12
NR11 2 3 5     EC 1.6.-.-3
BA350O14.91     Novel Reductase 13
NADPH-Dependent FMN And FAD-Containing Oxidoreductase2 3     

External Ids:    HGNC: 298381   Entrez Gene: 271582   Ensembl: ENSG000001885667   OMIM: 6060735   UniProtKB: Q9UHB43   

Export aliases for NDOR1 gene to outside databases

Previous GC identifers: GC09M9D0102 GC09P137375 GC09P139219 GC09P109559


Summaries
for NDOR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NDOR1:
This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin
adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through
FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
Function: Oxidoreductase that catalyzes the NADP-dependent reduction of cytochrome c and one-electron acceptors, such
as doxorubicin, potassium ferricyanide and menadione (in vitro)

Gene Wiki entry for NDOR1


Genomic Views
for NDOR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDOR1 gene promoter:
         CREB   RP58   deltaCREB   MyoD   Nkx2-5   Nkx5-1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDOR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDOR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NDOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDOR1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140100:  view genomic region     (about GC identifiers)

Start:
 140,100,119 bp from pter      End:
 140,113,813 bp from pter
Size:
 13,695 bases      Orientation:
 plus strand

Proteins
for NDOR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4 (See protein sequence)
Recommended Name: NADPH-dependent diflavin oxidoreductase 1  
Size: 597 amino acids; 66763 Da
Cofactor: FMN
Cofactor: FAD
Subunit: Interacts with DCPS
Subcellular location: Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure
Miscellaneous: Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression
with DCPS reduced this toxicity
Secondary accessions: D3YTH9 Q5VSG4 Q86US9 Q96BC6
Alternative splicing: 3 isoforms:  Q9UHB4-1   Q9UHB4-2   Q9UHB4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDOR1: NX_Q9UHB4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHB4

    • NDOR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137498.1  NP_001137499.1  NP_001137500.1  NP_055249.1  

    ENSEMBL proteins: 
     ENSP00000360576   ENSP00000343344   ENSP00000389905   ENSP00000394309  
    Reactome Protein details: Q9UHB4
    Human Recombinant Protein Products: 
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    Uscn Proteins for NDOR1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA16140270
    GO:0045111intermediate filament cytoskeleton IDA--
    GO:0048471perinuclear region of cytoplasm IEA--


    NDOR1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NDOR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDOR1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR001433 OxRdtase_FAD/NAD-bd
     IPR017938 Riboflavin_synthase-like_b-brl

    Graphical View of Domain Structure for InterPro Entry Q9UHB4

    ProtoNet protein and cluster: Q9UHB4

    4 Blocks protein families:
    IPB001094 Flavodoxin signature
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB008254 Flavodoxin/nitric oxide synthase


    UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
    Similarity: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 flavodoxin-like domain


    Function
    for NDOR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
    Function: Oxidoreductase that catalyzes the NADP-dependent reduction of cytochrome c and one-electron acceptors, such
    as doxorubicin, potassium ferricyanide and menadione (in vitro)
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for cytochrome c; Vmax=1.2 umol/min/ug enzyme for
    cytochrome c reduction; pH dependence: Optimum pH is about 8.0;

    Enzyme Number (IUBMB): EC 1.6.-.-1

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    hsa-miR-4291 hsa-miR-132* hsa-miR-1250 hsa-miR-15a hsa-miR-424 hsa-miR-296-5p hsa-miR-195 hsa-miR-15b
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    Gene Editing
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003958NADPH-hemoprotein reductase activity IBA--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI16140270
    GO:0010181FMN binding IDA10625700
    GO:0016491oxidoreductase activity IDA15900210


    NDOR1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NDOR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytosolic Iron-sulfur Cluster Assembly
    		Cytosolic Iron-sulfur Cluster Assembly1.00
    		4Fe-4S Cluster Forms on NUBP2:NUBP1 Scaffold0.38
    2Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for NDOR1
        4Fe-4S Cluster Forms on NUBP2:NUBP1 Scaffold
    Cytosolic Iron-sulfur Cluster Assembly
    Metabolism



    NDOR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for NDOR1 (Q9UHB43 ENSP000003605764) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523, ENSP000002938134I2D: score=1 STRING: ENSP00000293813
    CYCSP999993, ENSP000003077864I2D: score=2 STRING: ENSP00000307786
    DMC1Q145653I2D: score=1 
    EXOC6BQ9Y2D43I2D: score=1 
    POLD1P283403I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IDA16140270
    GO:0036245cellular response to menadione IDA16140270
    GO:0055114oxidation-reduction process IDA15900210


    NDOR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDOR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NDOR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NDOR1

    5 HMDB Compounds for NDOR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    PotassiumK+ (see all 16)7440-09-7--
    4 Novoseek chemical compound relationships for NDOR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 72.7 4 16140270 (2), 12631275 (1), 12871939 (1)
    nadph 59.3 13 12631275 (4), 12871939 (2), 16140270 (1), 15900210 (1)
    methionine 43.1 4 12871938 (2), 12871939 (1)
    nitric oxide 29.1 2 12871939 (1), 15900210 (1)

    Search CenterWatch for drugs/clinical trials and news about NDOR1 

    Transcripts
    for NDOR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDOR1 gene (4 alternative transcripts): 
    NM_001144026.1  NM_001144027.1  NM_001144028.1  NM_014434.2  

    Unigene Cluster for NDOR1:

    NADPH dependent diflavin oxidoreductase 1
    Hs.512564  [show with all ESTs]
    Unigene Representative Sequence: NM_001144026
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371521 ENST00000344894 ENST00000458322(uc004clx.3 uc004clw.3 uc011mes.2)
    ENST00000427047(uc004cly.3)

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    hsa-miR-4291 hsa-miR-132* hsa-miR-1250 hsa-miR-15a hsa-miR-424 hsa-miR-296-5p hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmid: NDOR1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF199509.1 AK026089.1 AK074403.1 AK225995.1 AK290026.1 AL133632.1 AY077845.1 BC015735.1 
    BC078668.1 BC093782.1 BC111943.1 BC143229.1 

    12 DOTS entries:

    DT.434952  DT.100653562  DT.97838222  DT.100780834  DT.40222174  DT.100780836  DT.97840599  DT.95371246 
    DT.95110925  DT.100756722  DT.409552  DT.121161102 

    24/101 AceView cDNA sequences (see all 101):

    BQ921414 BE018818 AI056444 AI750243 AY077845 CB153702 CA394193 AK074403 
    CA431674 AI240361 BC078668 BU501986 BF508870 BC015735 AI653278 AA357341 
    BF591325 AW169964 T12637 AK026089 BI918448 AF199509 CB142526 BX363538 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                          -                 -                                   -                                                                       -   
    SP2:                          -                 -                                   -                                                     -                 -   
    SP3:                          -                 -           -                       -                                                     -           -     -   
    SP4:                          -                 -                 -     -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for NDOR1

    Expression
    for NDOR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDOR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACCACACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NDOR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDOR1

    SOURCE GeneReport for Unigene cluster: Hs.512564

    UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
    Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in
    the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia,
    lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361

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    In Situ
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    Orthologs
    for NDOR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NDOR1 gene from 10/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NDOR11 NADPH dependent diflavin oxidoreductase 1 70.08(n)
    68.46(a)    		   417280  XM_415553.2  XP_415553.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NOS16
    NDOR16
    (see all 6)    		 --
    		 9(a)
    67(a)
    (see all 6)    		 possible ortholog
    1 ↔ 1
    (see all 6)    		 LGb(2418671-2462979)
    GL344097.1(1892-21914)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.281482 Xenopus laevis transcribed sequence with weak similarity to protein refNP_055249.1 (H.sapiens) NADPH-dependent FMN and FAD containing oxidoreductase [Homo sapiens] less 75.22(n)    CA973485.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc661592 hypothetical protein MGC66159 75.13(n)   393621  BC057471.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG136671 CG13667 49.77(n)
    41.75(a)    		   38956  NM_139963.1  NP_648220.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fre-11 Protein FRE-1 47.42(n)
    42.78(a)    		   180314  NM_075474.3  NP_507875.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TAH18(YPR048W)4
    TAH181    		 Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress less4
    Tah18p1    		 41.37(n)1
    32.01(a)1    		   16(659182-661053)4
    8561611, 4  NP_015373.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G022801 flavodoxin-like protein 47.92(n)
    43.76(a)    		   820417  NM_111095.4  NP_186877.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07336001 hypothetical protein 47.55(n)
    42.15(a)    		   4324160  NM_001050697.1  NP_001044162.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria cysJ6
    		 sulfite reductase, alpha subunit, flavoprotein
    		 27(a)
    		 possible ortholog
    		 Chromosome(2888121-2889920)


    ENSEMBL Gene Tree for NDOR1 (if available)
    TreeFam Gene Tree for NDOR1 (if available) 

    Paralogs
    for NDOR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NDOR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 NCBI SNPs in NDOR1 are shown (see all 326)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1889549851,2
    		--140098129(+) TTTAGC/GGGTGT 5 -- us2k1 int10--------
    rs1127654711,2
    		F--140098161(+) GGTCAC/TACAAA 5 -- us2k1 int12Minor allele frequency- T:0.50CSA 4
    rs1930864721,2
    		--140098202(+) CTGCTC/TTACAG 5 -- int1 us2k10--------
    rs1850066111,2
    		--140098303(+) CAGATG/TGTTGT 5 -- us2k1 int10--------
    rs1482828671,2
    		--140098539(+) TTTCAG/TGAAAA 5 -- ut31 us2k10--------
    rs1428717811,2
    		--140098616(+) AGTTCA/GTAGGC 5 -- us2k1 ut310--------
    rs788504351,2
    		C,--140098903(+) TAGACA/TGGAAT 5 -- us2k1 ut310--------
    rs1396311901,2
    		--140099085(+) CAACAC/GTACTT 5 -- us2k1 ut310--------
    rs1902469211,2
    		--140099199(+) CTCATG/TACCTC 5 -- us2k1 ut310--------
    rs1134044691,2
    		--140099200(+) TCATGT/ACCTCA 5 -- us2k1 ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for NDOR1 (140100119 - 140113813 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NDOR1
         1 CNV: 5415
    Human Gene Mutation Database (HGMD): NDOR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDOR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NDOR1

    Disorders / Diseases
    for NDOR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDOR1 for disorders           About GeneDecksing

    OMIM gene information: 606073    OMIM disorders: --

    13 diseases for NDOR1:    About MalaCards
    toxic encephalopathy    burkitt's lymphoma    teratoma    lymphoblastic leukemia
    brain disease    pharyngitis    lung carcinoma    leukemia
    melanoma    adenocarcinoma    carcinoma    prostatitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NDOR1 (2 documents)

    Export disorders for NDOR1 gene to outside databases

    Publications
    for NDOR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDOR1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with NDOR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human dual flavin reductase. (PubMed id 10625700)1, 2, 3 Paine M.J.... Wolf C.R. (2000)
    2. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PubMed id 15900210)1, 2, 9 Finn R.D.... Paine M.J. (2005)
    3. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 2, 9 Kwasnicka-Crawford D.A. and Vincent S.R. (2005)
    4. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PubMed id 12631275)1, 3, 9 Finn R.D....Scrutton N.S. (2003)
    5. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 2, 9 Kwasnicka D.A.... Vincent S.R. (2003)
    6. Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1. (PubMed id 12871938)1, 9 Olteanu H. and Banerjee R. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Characterisation of the expression of NMDA receptors in human astrocytes. (PubMed id 21152063)1 Lee M.C....Guillemin G.J. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for NDOR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDOR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27158 HGNC: 29838 AceView: NDOR1 Ensembl:ENSG00000188566 euGenes: HUgn27158
    ECgene: NDOR1 H-InvDB: NDOR1

    Other Databases showing NDOR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NDOR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDOR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NDOR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDOR1 gene:
    Search GeneIP for patents involving NDOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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