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Aliases for NDOR1 Gene

Aliases for NDOR1 Gene

  • NADPH Dependent Diflavin Oxidoreductase 1 2 3
  • NR1 3 4 6
  • NADPH-Dependent FMN And FAD-Containing Oxidoreductase 3 4
  • NADPH Dependent FMN And FAD Containing Oxidoreductase 2
  • NADPH-Dependent Diflavin Oxidoreductase 1 3
  • Novel Reductase 1 4
  • BA350O14.9 3
  • EC 1.6.-.- 4

External Ids for NDOR1 Gene

Previous GeneCards Identifiers for NDOR1 Gene

  • GC09M9D0102
  • GC09P137375
  • GC09P139219
  • GC09P140100
  • GC09P109559

Summaries for NDOR1 Gene

Entrez Gene Summary for NDOR1 Gene

  • This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDOR1 Gene

NDOR1 (NADPH Dependent Diflavin Oxidoreductase 1) is a Protein Coding gene. Diseases associated with NDOR1 include colorectal adenocarcinoma. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly. GO annotations related to this gene include iron ion binding and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot for NDOR1 Gene

  • Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Gene Wiki entry for NDOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDOR1 Gene

Genomics for NDOR1 Gene

Regulatory Elements for NDOR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDOR1 Gene

Start:
137,205,667 bp from pter
End:
137,219,361 bp from pter
Size:
13,695 bases
Orientation:
Plus strand

Genomic View for NDOR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDOR1 Gene

Proteins for NDOR1 Gene

  • Protein details for NDOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB4-NDOR1_HUMAN
    Recommended name:
    NADPH-dependent diflavin oxidoreductase 1
    Protein Accession:
    Q9UHB4
    Secondary Accessions:
    • D3YTG6
    • D3YTH9
    • Q5VSG4
    • Q86US9
    • Q96BC6

    Protein attributes for NDOR1 Gene

    Size:
    597 amino acids
    Molecular mass:
    66763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Interacts with CIAPIN1. Interacts with DCPS.
    Miscellaneous:
    • Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression with DCPS reduced this toxicity

    Three dimensional structures from OCA and Proteopedia for NDOR1 Gene

    Alternative splice isoforms for NDOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDOR1 Gene

Proteomics data for NDOR1 Gene at MOPED

Post-translational modifications for NDOR1 Gene

  • Ubiquitination at Lys207
  • Modification sites at PhosphoSitePlus

Other Protein References for NDOR1 Gene

No data available for DME Specific Peptides for NDOR1 Gene

Domains for NDOR1 Gene

Suggested Antigen Peptide Sequences for NDOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHB4

UniProtKB/Swiss-Prot:

NDOR1_HUMAN :
  • Q9UHB4
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 flavodoxin-like domain.
Family:
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with NDOR1: view

No data available for Gene Families for NDOR1 Gene

Function for NDOR1 Gene

Molecular function for NDOR1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=21 uM for cytochrome c {ECO:0000269 PubMed:10625700}; Vmax=1.2 umol/min/ug enzyme for cytochrome c reduction {ECO:0000269 PubMed:10625700}; pH dependence: Optimum pH is about 8.0. {ECO:0000269 PubMed:10625700};
UniProtKB/Swiss-Prot Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Enzyme Numbers (IUBMB) for NDOR1 Gene

Gene Ontology (GO) - Molecular Function for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003958 NADPH-hemoprotein reductase activity IBA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 16140270
GO:0010181 FMN binding IDA 10625700
GO:0016491 oxidoreductase activity IDA 10625700
genes like me logo Genes that share ontologies with NDOR1: view

Animal Model Products

CRISPR Products

miRNA for NDOR1 Gene

miRTarBase miRNAs that target NDOR1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDOR1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDOR1 Gene

Localization for NDOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDOR1 Gene

Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDOR1 Gene COMPARTMENTS Subcellular localization image for NDOR1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
endoplasmic reticulum 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 16140270
GO:0045111 intermediate filament cytoskeleton IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NDOR1: view

Pathways for NDOR1 Gene

genes like me logo Genes that share pathways with NDOR1: view

Pathways by source for NDOR1 Gene

2 Reactome pathways for NDOR1 Gene

Gene Ontology (GO) - Biological Process for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IDA 16140270
GO:0016226 iron-sulfur cluster assembly IEA --
GO:0036245 cellular response to menadione IDA 16140270
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IDA 10625700
genes like me logo Genes that share ontologies with NDOR1: view

Compounds for NDOR1 Gene

(5) HMDB Compounds for NDOR1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Flavin Mononucleotide
  • FMN
146-17-8
Menadione
  • Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
58-27-5
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
Potassium
  • K+
7440-09-7

(4) Novoseek inferred chemical compound relationships for NDOR1 Gene

Compound -log(P) Hits PubMed IDs
flavin 72.7 4
nadph 59.3 8
methionine 43.1 3
nitric oxide 29.1 2
genes like me logo Genes that share compounds with NDOR1: view

Transcripts for NDOR1 Gene

Unigene Clusters for NDOR1 Gene

NADPH dependent diflavin oxidoreductase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDOR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NDOR1 Gene

GeneLoc Exon Structure for
NDOR1
ECgene alternative splicing isoforms for
NDOR1

Expression for NDOR1 Gene

mRNA expression in normal human tissues for NDOR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDOR1 Gene

SOURCE GeneReport for Unigene cluster for NDOR1 Gene Hs.512564

mRNA Expression by UniProt/SwissProt for NDOR1 Gene

Q9UHB4-NDOR1_HUMAN
Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitts lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.
genes like me logo Genes that share expressions with NDOR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NDOR1 Gene

Orthologs for NDOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDOR1 35
  • 99.39 (n)
  • 99.01 (a)
NDOR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDOR1 35
  • 83.86 (n)
  • 82.41 (a)
NDOR1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDOR1 35
  • 84.42 (n)
  • 84.59 (a)
NDOR1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndor1 35
  • 80.29 (n)
  • 81.74 (a)
Ndor1 16
Ndor1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDOR1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndor1 35
  • 80.23 (n)
  • 81.57 (a)
chicken
(Gallus gallus)
Aves NDOR1 35
  • 70.08 (n)
  • 68.46 (a)
NDOR1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDOR1 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28148 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndor1 35
  • 65.71 (n)
  • 60.94 (a)
zebrafish
(Danio rerio)
Actinopterygii ndor1 35
  • 61.12 (n)
  • 60 (a)
ndor1 36
  • 60 (a)
OneToOne
zgc66159 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003889 35
  • 53.18 (n)
  • 44.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13667 35
  • 50.69 (n)
  • 43.42 (a)
CG13667 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fre-1 35
  • 47.38 (n)
  • 43.04 (a)
fre-1 36
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL306C 35
  • 44.66 (n)
  • 35.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAH18 35
  • 42 (n)
  • 33.28 (a)
TAH18 36
  • 29 (a)
OneToOne
TAH18 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12155g 35
  • 43.14 (n)
  • 32.7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02280 35
  • 48.29 (n)
  • 44.35 (a)
rice
(Oryza sativa)
Liliopsida Os01g0733600 35
  • 47 (n)
  • 41.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09727 35
  • 47.65 (n)
  • 39.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tah18 35
  • 43.05 (n)
  • 36.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13988 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for NDOR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDOR1 Gene

ENSEMBL:
Gene Tree for NDOR1 (if available)
TreeFam:
Gene Tree for NDOR1 (if available)

Paralogs for NDOR1 Gene

Selected SIMAP similar genes for NDOR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NDOR1: view

No data available for Paralogs for NDOR1 Gene

Variants for NDOR1 Gene

Sequence variations from dbSNP and Humsavar for NDOR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7031301 -- 137,210,252(-) agagc(A/G)agagc intron-variant
rs7033551 -- 137,207,652(-) AACAC(C/T)CACTC intron-variant
rs7047363 -- 137,211,098(-) aatgg(C/T)gcgac intron-variant
rs7388751 -- 137,208,487(-) TTTTT(G/T)TTTGT intron-variant
rs7389314 -- 137,212,884(-) CACAG(A/C)ACGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDOR1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894629 CNV Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894639 CNV Loss 21882294
esv2739415 CNV Deletion 23290073
esv2739416 CNV Deletion 23290073
nsv894640 CNV Loss 21882294

Relevant External Links for NDOR1 Gene

HapMap Linkage Disequilibrium report
NDOR1
Human Gene Mutation Database (HGMD)
NDOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDOR1 Gene

Disorders for NDOR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NDOR1 Gene including...

Search for NDOR1 Gene in MalaCards »

Relevant External Links for NDOR1

Human Genome Epidemiology (HuGE) Navigator
NDOR1
genes like me logo Genes that share disorders with NDOR1: view

No data available for UniProtKB/Swiss-Prot for NDOR1 Gene

Publications for NDOR1 Gene

  1. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PMID: 12871939) Kwasnicka D.A. … Vincent S.R. (J. Biol. Chem. 2003) 3 4 23
  2. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PMID: 15900210) Finn R.D. … Paine M.J. (Pharmacogenet. Genomics 2005) 3 4 23
  3. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwasnicka-Crawford D.A. … Vincent S.R. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  4. Cloning and characterization of a novel human dual flavin reductase. (PMID: 10625700) Paine M.J. … Wolf C.R. (J. Biol. Chem. 2000) 2 3 4
  5. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PMID: 12631275) Finn R.D. … Scrutton N.S. (Eur. J. Biochem. 2003) 2 3 23

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