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Aliases for NDOR1 Gene

Aliases for NDOR1 Gene

  • NADPH Dependent Diflavin Oxidoreductase 1 2 3 5
  • NADPH-Dependent FMN And FAD-Containing Oxidoreductase 3 4
  • NR1 3 4
  • NADPH Dependent FMN And FAD Containing Oxidoreductase 2
  • Novel Reductase 1 4
  • EC 1.18.1.- 4
  • BA350O14.9 3

External Ids for NDOR1 Gene

Previous GeneCards Identifiers for NDOR1 Gene

  • GC09M9D0102
  • GC09P137375
  • GC09P139219
  • GC09P140100
  • GC09P109559

Summaries for NDOR1 Gene

Entrez Gene Summary for NDOR1 Gene

  • This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDOR1 Gene

NDOR1 (NADPH Dependent Diflavin Oxidoreductase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is NOS1.

UniProtKB/Swiss-Prot for NDOR1 Gene

  • Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Gene Wiki entry for NDOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDOR1 Gene

Genomics for NDOR1 Gene

Regulatory Elements for NDOR1 Gene

Enhancers for NDOR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDOR1 on UCSC Golden Path with GeneCards custom track

Promoters for NDOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDOR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDOR1 Gene

Chromosome:
9
Start:
137,205,667 bp from pter
End:
137,219,361 bp from pter
Size:
13,695 bases
Orientation:
Plus strand

Genomic View for NDOR1 Gene

Genes around NDOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDOR1 Gene

Proteins for NDOR1 Gene

  • Protein details for NDOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB4-NDOR1_HUMAN
    Recommended name:
    NADPH-dependent diflavin oxidoreductase 1
    Protein Accession:
    Q9UHB4
    Secondary Accessions:
    • D3YTG6
    • D3YTH9
    • Q5VSG4
    • Q86US9
    • Q96BC6

    Protein attributes for NDOR1 Gene

    Size:
    597 amino acids
    Molecular mass:
    66763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Interacts with CIAPIN1. Interacts with DCPS.
    Miscellaneous:
    • Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression with DCPS reduced this toxicity.

    Three dimensional structures from OCA and Proteopedia for NDOR1 Gene

    Alternative splice isoforms for NDOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDOR1 Gene

Proteomics data for NDOR1 Gene at MOPED

Post-translational modifications for NDOR1 Gene

  • Ubiquitination at Lys 207
  • Modification sites at PhosphoSitePlus

Other Protein References for NDOR1 Gene

No data available for DME Specific Peptides for NDOR1 Gene

Domains & Families for NDOR1 Gene

Suggested Antigen Peptide Sequences for NDOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHB4

UniProtKB/Swiss-Prot:

NDOR1_HUMAN :
  • Contains 1 FAD-binding FR-type domain.
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 flavodoxin-like domain.
Family:
  • Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
  • In the N-terminal section; belongs to the flavodoxin family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with NDOR1: view

No data available for Gene Families for NDOR1 Gene

Function for NDOR1 Gene

Molecular function for NDOR1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for cytochrome c {ECO:0000269 PubMed:10625700}; Vmax=1.2 umol/min/ug enzyme for cytochrome c reduction {ECO:0000269 PubMed:10625700}; pH dependence: Optimum pH is about 8.0. {ECO:0000269 PubMed:10625700};
UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.

Enzyme Numbers (IUBMB) for NDOR1 Gene

Gene Ontology (GO) - Molecular Function for NDOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16140270
genes like me logo Genes that share ontologies with NDOR1: view
genes like me logo Genes that share phenotypes with NDOR1: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDOR1 Gene

Localization for NDOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDOR1 Gene

Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure. {ECO:0000255 HAMAP-Rule:MF_03178, ECO:0000269 PubMed:12871939}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDOR1 Gene COMPARTMENTS Subcellular localization image for NDOR1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NDOR1 Gene

Pathways & Interactions for NDOR1 Gene

genes like me logo Genes that share pathways with NDOR1: view

Pathways by source for NDOR1 Gene

2 Reactome pathways for NDOR1 Gene

Gene Ontology (GO) - Biological Process for NDOR1 Gene

None

No data available for SIGNOR curated interactions for NDOR1 Gene

Drugs & Compounds for NDOR1 Gene

(6) Drugs for NDOR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Menadione Approved Nutra 207
Flavin Mononucleotide Experimental Pharma 6
Potassium Experimental Pharma 0

(3) Additional Compounds for NDOR1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with NDOR1: view

Transcripts for NDOR1 Gene

Unigene Clusters for NDOR1 Gene

NADPH dependent diflavin oxidoreductase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NDOR1 Gene

GeneLoc Exon Structure for
NDOR1
ECgene alternative splicing isoforms for
NDOR1

Expression for NDOR1 Gene

mRNA expression in normal human tissues for NDOR1 Gene

Protein differential expression in normal tissues from HIPED for NDOR1 Gene

This gene is overexpressed in CD4 Tcells (38.5), Placenta (11.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDOR1 Gene



SOURCE GeneReport for Unigene cluster for NDOR1 Gene Hs.512564

mRNA Expression by UniProt/SwissProt for NDOR1 Gene

Q9UHB4-NDOR1_HUMAN
Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitts lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.
genes like me logo Genes that share expression patterns with NDOR1: view

Protein tissue co-expression partners for NDOR1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NDOR1 Gene

Orthologs for NDOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDOR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDOR1 35
  • 83.86 (n)
  • 82.41 (a)
NDOR1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDOR1 35
  • 84.42 (n)
  • 84.59 (a)
NDOR1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndor1 35
  • 80.29 (n)
  • 81.74 (a)
Ndor1 16
Ndor1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDOR1 35
  • 99.39 (n)
  • 99.01 (a)
NDOR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndor1 35
  • 80.23 (n)
  • 81.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NDOR1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDOR1 35
  • 70.08 (n)
  • 68.46 (a)
NDOR1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDOR1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndor1 35
  • 65.71 (n)
  • 60.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28148 35
zebrafish
(Danio rerio)
Actinopterygii ndor1 35
  • 61.12 (n)
  • 60 (a)
zgc66159 35
ndor1 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003889 35
  • 53.18 (n)
  • 44.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13667 35
  • 50.69 (n)
  • 43.42 (a)
CG13667 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fre-1 35
  • 47.38 (n)
  • 43.04 (a)
fre-1 36
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL306C 35
  • 44.66 (n)
  • 35.18 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12155g 35
  • 43.14 (n)
  • 32.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAH18 35
  • 42 (n)
  • 33.28 (a)
TAH18 36
  • 29 (a)
OneToOne
TAH18 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02280 35
  • 48.29 (n)
  • 44.35 (a)
rice
(Oryza sativa)
Liliopsida Os01g0733600 35
  • 47 (n)
  • 41.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13988 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09727 35
  • 47.65 (n)
  • 39.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tah18 35
  • 43.05 (n)
  • 36.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for NDOR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDOR1 Gene

ENSEMBL:
Gene Tree for NDOR1 (if available)
TreeFam:
Gene Tree for NDOR1 (if available)

Paralogs for NDOR1 Gene

Paralogs for NDOR1 Gene

(2) SIMAP similar genes for NDOR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NDOR1: view

Variants for NDOR1 Gene

Sequence variations from dbSNP and Humsavar for NDOR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs62587579 - 137,216,103(+) AGAAA(A/G)TATAT nc-transcript-variant, reference, missense
rs7469085 -- 137,213,469(-) GGGAC(C/T)TGAGG intron-variant, upstream-variant-2KB
rs7859283 -- 137,218,727(-) AGGCC(A/C)CTGCC nc-transcript-variant, utr-variant-3-prime
rs112987747 -- 137,215,991(+) TGACC(C/G)TCATC nc-transcript-variant, reference, missense
rs113046870 -- 137,214,827(+) CCCAG(C/G)CCTGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NDOR1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894629 CNV Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894639 CNV Loss 21882294
esv2739415 CNV Deletion 23290073
esv2739416 CNV Deletion 23290073
nsv894640 CNV Loss 21882294

Variation tolerance for NDOR1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDOR1 Gene

Human Gene Mutation Database (HGMD)
NDOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDOR1 Gene

Disorders for NDOR1 Gene

Relevant External Links for NDOR1

Human Genome Epidemiology (HuGE) Navigator
NDOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDOR1

No disorders were found for NDOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDOR1 Gene

Publications for NDOR1 Gene

  1. Cloning and characterization of a novel human dual flavin reductase. (PMID: 10625700) Paine M.J. … Wolf C.R. (J. Biol. Chem. 2000) 2 3 4 67
  2. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PMID: 12631275) Finn R.D. … Scrutton N.S. (Eur. J. Biochem. 2003) 2 3 23
  3. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PMID: 15900210) Finn R.D. … Paine M.J. (Pharmacogenet. Genomics 2005) 3 23
  4. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PMID: 16140270) Kwasnicka-Crawford D.A. … Vincent S.R. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1. (PMID: 12871938) Olteanu H. … Banerjee R. (J. Biol. Chem. 2003) 3 23

Products for NDOR1 Gene

Sources for NDOR1 Gene

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