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NDOR1 Gene

protein-coding   GIFtS: 59
GCID: GC09P140100

NADPH Dependent Diflavin Oxidoreductase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADPH Dependent Diflavin Oxidoreductase 11 2     bA350O14.92
NR12 3 5     NADPH-Dependent Diflavin Oxidoreductase 12
NADPH-Dependent FMN And FAD-Containing Oxidoreductase2 3     EC 1.6.-.-3
NADPH Dependent FMN And FAD Containing Oxidoreductase1     Novel Reductase 13

External Ids:    HGNC: 298381   Entrez Gene: 271582   Ensembl: ENSG000001885667   OMIM: 6060735   UniProtKB: Q9UHB43   

Export aliases for NDOR1 gene to outside databases

Previous GC identifers: GC09M9D0102 GC09P137375 GC09P139219 GC09P109559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDOR1 Gene:
This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin
adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH
through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2012)

GeneCards Summary for NDOR1 Gene:
NDOR1 (NADPH dependent diflavin oxidoreductase 1) is a protein-coding gene. Diseases associated with NDOR1 include toxic encephalopathy, and teratoma. GO annotations related to this gene include iron ion binding and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the
maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in
an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1

Gene Wiki entry for NDOR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDOR1 gene promoter:
         CREB   RP58   deltaCREB   MyoD   Nkx2-5   Nkx5-1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDOR1 promoter sequence
   Search Chromatin IP Primers for NDOR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NDOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDOR1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140100:  view genomic region     (about GC identifiers)

Start:
140,100,119 bp from pter      End:
140,113,813 bp from pter
Size:
13,695 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4 (See protein sequence)
Recommended Name: NADPH-dependent diflavin oxidoreductase 1  
Size: 597 amino acids; 66763 Da
Cofactor: FMN
Cofactor: FAD
Subunit: Interacts with CIAPIN1. Interacts with DCPS
Miscellaneous: Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death,
coexpression with DCPS reduced this toxicity
1 PDB 3D structure from and Proteopedia for NDOR1:
4H2D (3D)    
Secondary accessions: D3YTG6 D3YTH9 Q5VSG4 Q86US9 Q96BC6
Alternative splicing: 4 isoforms:  Q9UHB4-1   Q9UHB4-2   Q9UHB4-3   Q9UHB4-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for NDOR1: NX_Q9UHB4

Explore proteomics data for NDOR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys207
  • Modification sites at PhosphoSitePlus

  • See NDOR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137498.1  NP_001137499.1  NP_001137500.1  NP_055249.1  

    ENSEMBL proteins: 
     ENSP00000360576   ENSP00000343344   ENSP00000394309   ENSP00000389905  
    Reactome Protein details: Q9UHB4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR001433 OxRdtase_FAD/NAD-bd
     IPR003097 FAD-binding_1

    Graphical View of Domain Structure for InterPro Entry Q9UHB4

    ProtoNet protein and cluster: Q9UHB4

    4 Blocks protein domains:
    IPB001094 Flavodoxin signature
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB008254 Flavodoxin/nitric oxide synthase


    UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
    Similarity: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family
    Similarity: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 flavodoxin-like domain


    NDOR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDOR1_HUMAN, Q9UHB4
    Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the
    maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in
    an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for cytochrome c; Vmax=1.2 umol/min/ug enzyme for
    cytochrome c reduction; pH dependence: Optimum pH is about 8.0;

         Enzyme Number (IUBMB): EC 1.6.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003958NADPH-hemoprotein reductase activity IBA--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI16140270
    GO:0010181FMN binding IDA10625700
    GO:0016491oxidoreductase activity IDA10625700
         
    NDOR1 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDOR1 (see all 29):
    hsa-miR-4291 hsa-miR-132* hsa-miR-1250 hsa-miR-15a hsa-miR-424 hsa-miR-296-5p hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidNDOR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDOR1

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    Sino Biological Human cDNA Clone for NDOR1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDOR1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDOR1_HUMAN, Q9UHB4: Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    cytoskeleton4
    nucleus4
    endoplasmic reticulum1
    extracellular1
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA16140270
    GO:0045111intermediate filament cytoskeleton IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    NDOR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDOR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NDOR1
        Cytosolic iron-sulfur cluster assembly



    NDOR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDOR1
    Interactions:

        Search GeneGlobe Interaction Network for NDOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for NDOR1 (Q9UHB43 ENSP000003605764) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYCSP999993, ENSP000003077864I2D: score=2 STRING: ENSP00000307786
    UBR1Q8IWV73, ENSP000002906504I2D: score=1 STRING: ENSP00000290650
    DLG4P783523I2D: score=1 
    DMC1Q145653I2D: score=1 
    EXOC6BQ9Y2D43I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IDA16140270
    GO:0016226iron-sulfur cluster assembly IEA--
    GO:0036245cellular response to menadione IDA16140270
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process IDA10625700

    NDOR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDOR1

    5 HMDB Compounds for NDOR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    PotassiumK+ (see all 16)7440-09-7--

    4 Novoseek inferred chemical compound relationships for NDOR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 72.7 4 16140270 (2), 12631275 (1), 12871939 (1)
    nadph 59.3 13 12631275 (4), 12871939 (2), 16140270 (1), 15900210 (1)
    methionine 43.1 4 12871938 (2), 12871939 (1)
    nitric oxide 29.1 2 12871939 (1), 15900210 (1)



    NDOR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDOR1 gene (4 alternative transcripts): 
    NM_001144026.2  NM_001144027.2  NM_001144028.2  NM_014434.3  

    Unigene Cluster for NDOR1:

    NADPH dependent diflavin oxidoreductase 1
    Hs.512564  [show with all ESTs]
    Unigene Representative Sequence: NM_001144026
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371521 ENST00000344894 ENST00000427047(uc004cly.3) ENST00000458322(uc004clx.3 uc004clw.3 uc011mes.2)

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    Selected qRT-PCR Assays for microRNAs that regulate NDOR1 (see all 29):
    hsa-miR-4291 hsa-miR-132* hsa-miR-1250 hsa-miR-15a hsa-miR-424 hsa-miR-296-5p hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidNDOR1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NDOR1

    Additional mRNA sequence: 

    AF199509.1 AK026089.1 AK074403.1 AK225995.1 AK290026.1 AL133632.1 AY077845.1 BC015735.1 
    BC078668.1 BC093782.1 BC111943.1 BC143229.1 

    12 DOTS entries:

    DT.434952  DT.100653562  DT.97838222  DT.100780834  DT.40222174  DT.100780836  DT.97840599  DT.95371246 
    DT.95110925  DT.100756722  DT.409552  DT.121161102 

    Selected AceView cDNA sequences (see all 101):

    AI056444 BF591325 BQ921414 AK074403 CB153702 BE018818 AY077845 BC078668 
    AI240361 BF508870 T12637 AW169964 AA357341 CA394193 AI653278 BU501986 
    BC015735 AK026089 CA431674 AI750243 M78934 BE873940 BX363538 AI080236 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDOR1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                          -                 -                                   -                                                                       -   
    SP2:                          -                 -                                   -                                                     -                 -   
    SP3:                          -                 -           -                       -                                                     -           -     -   
    SP4:                          -                 -                 -     -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for NDOR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDOR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCACACC
    NDOR1 Expression
    About this image

    NDOR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDOR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512564

    UniProtKB/Swiss-Prot: NDOR1_HUMAN, Q9UHB4
    Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels
    in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous
    leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma
    G-361

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDOR1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndor11 , 5 NADPH dependent diflavin oxidoreductase 11, 5 80.29(n)1
    81.74(a)1
      2 (17.10 cM)5
    787971  NM_001082476.21  NP_001075945.11 
     252448215 
    chicken
    (Gallus gallus)
    Aves NDOR11 NADPH dependent diflavin oxidoreductase 1 70.08(n)
    68.46(a)
      417280  XM_415553.3  XP_415553.3 
    lizard
    (Anolis carolinensis)
    Reptilia NDOR16
    NADPH dependent diflavin oxidoreductase 1
    67(a)
    1 ↔ 1
    GL344097.1(1716-26724)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.281482 Xenopus laevis transcribed sequence with weak similarity more 75.22(n)    CA973485.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661592 hypothetical protein MGC66159 75.13(n)   393621  BC057471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136671 CG13667 50.69(n)
    43.42(a)
      38956  NM_139963.2  NP_648220.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fre-11 fre-1 47.38(n)
    43.04(a)
      180314  NM_075474.4  NP_507875.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAH18(YPR048W)4
    TAH181
    Conserved NAPDH-dependent diflavin reductase, component more4
    TAH181
    42(n)1
    33.28(a)1
      16(659182-661053)4
    8561611, 4  NP_015373.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G022801 AT3G02280 48.29(n)
    44.35(a)
      820417  NM_111095.4  NP_186877.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g07336001 Os01g0733600 47(n)
    41.16(a)
      4324160  NM_001050697.1  NP_001044162.1 


    ENSEMBL Gene Tree for NDOR1 (if available)
    TreeFam Gene Tree for NDOR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDOR1 gene
    2 SIMAP similar genes for NDOR1 using alignment to 1 protein entry:     NDOR1_HUMAN:
    DKFZp686G04235    POR

    NDOR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NDOR1 (see all 413)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70335511,2
    C--140102104(-) AACACC/TCACTC 4 -- int110Minor allele frequency- T:0.23NA WA CSA 137
    rs1411909461,2
    --140102220(+) AGAGCA/GGCTTC 4 -- int10--------
    rs1507274621,2
    C--140102300(+) TTAAGA/GATGTC 4 -- int10--------
    rs1390584011,2
    C--140102319(+) GGGCCA/GGCTGC 4 -- int10--------
    rs798509171,2
    C--140102586(+) GAGCTG/AGACTC 4 -- int11Minor allele frequency- A:0.50WA 2
    rs343277831,2
    C--140102595(+) CTGTC-/AAAAAA 4 -- int11Minor allele frequency- A:0.50NA 2
    rs1826094261,2
    --140102608(+) AAAAAA/GAAAAG 4 -- int10--------
    rs1466217931,2
    --140102623(+) AGAGCC/TGGGCA 4 -- int10--------
    rs358448151,2
    C--140102759(+) CTAGCT/CGGATG 4 -- int12Minor allele frequency- C:0.25NA WA 4
    rs1438397091,2
    --140102760(+) TAGCCA/GGATGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for NDOR1 (140100119 - 140113813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NDOR1 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739415CNV Deletion23290073
    esv2422220CNV Deletion17116639
    esv2739416CNV Deletion23290073
    nsv894640CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8441n71CNV Loss21882294
    dgv8456n71CNV Loss21882294
    nsv894521CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894469CNV Loss21882294

    Human Gene Mutation Database (HGMD): NDOR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDOR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NDOR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606073    OMIM disorders: --

    12 diseases for NDOR1:    About MalaCards
    toxic encephalopathy    teratoma    brain disease    burkitt's lymphoma
    lymphoblastic leukemia    malaria    melanoma    adenocarcinoma
    leukemia    endotheliitis    prostatitis    neuronitis


    NDOR1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: NDOR1 (2 documents)

    Export disorders for NDOR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDOR1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NDOR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human dual flavin reductase. (PubMed id 10625700)1, 2, 3 Paine M.J.... Wolf C.R. (J. Biol. Chem. 2000)
    2. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1. (PubMed id 15900210)1, 2, 9 Finn R.D.... Paine M.J. (Pharmacogenet. Genomics 2005)
    3. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 2, 9 Kwasnicka-Crawford D.A. and Vincent S.R. (Biochem. Biophys. Res. Commun. 2005)
    4. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. (PubMed id 12631275)1, 3, 9 Finn R.D....Scrutton N.S. (Eur. J. Biochem. 2003)
    5. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 2, 9 Kwasnicka D.A.... Vincent S.R. (J. Biol. Chem. 2003)
    6. Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. (PubMed id 23596212)1, 2 Banci L....Winkelmann J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. (PubMed id 20802492)1, 2 Netz D.J....Lill R. (Nat. Chem. Biol. 2010)
    8. Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1. (PubMed id 12871938)1, 9 Olteanu H. and Banerjee R. (J. Biol. Chem. 2003)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27158 HGNC: 29838 AceView: NDOR1 Ensembl:ENSG00000188566 euGenes: HUgn27158
    ECgene: NDOR1 H-InvDB: NDOR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDOR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDOR1 gene:
    Search GeneIP for patents involving NDOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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