Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDNL2 Gene

protein-coding   GIFtS: 50
GCID: GC15M029560

Necdin-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Necdin-Like 21 2     NSE32
MAGEG12 3 5     NSMCE32
Hepatocellular Carcinoma-Associated Protein 42 3     Hepatocellular Carcinoma-Associated Protein HCA42
Necdin-Like Protein 22 3     Melanoma Antigen, Family G, 12
HCA42 3     Melanoma-Associated Antigen G12
MAGE-G1 Antigen2 3     Necdin-Like Gene 22
MAGEL32     

External Ids:    HGNC: 76771   Entrez Gene: 561602   Ensembl: ENSG000001851157   OMIM: 6082435   UniProtKB: Q96MG73   

Export aliases for NDNL2 gene to outside databases

Previous GC identifers: GC00U990785 GC15U900046 GC15M027276 GC15M027347 GC15M007218


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDNL2 Gene:
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE
superfamily. This is an intronless gene. (provided by RefSeq, May 2011)

GeneCards Summary for NDNL2 Gene: 
NDNL2 (necdin-like 2) is a protein-coding gene. Diseases associated with NDNL2 include hepatocellular carcinoma, and melanoma. GO annotations related to this gene include protein binding. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGG1_HUMAN, Q96MG7
Function: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or
stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that
facilitates the entry of the cell into cell cycle arrest




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDNL2 gene promoter:
         LHX3b/Lhx3b   p53   SREBP-1c   CUTL1   SREBP-1b   GATA-2   SREBP-1a   POU2F1   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDNL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDNL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.1   Ensembl cytogenetic band:  15q13.1   HGNC cytogenetic band: 15q13.1

NDNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDNL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M029560:  view genomic region     (about GC identifiers)

Start:
29,560,353 bp from pter      End:
29,562,033 bp from pter
Size:
1,681 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGG1_HUMAN, Q96MG7 (See protein sequence)
Recommended Name: Melanoma-associated antigen G1  
Size: 304 amino acids; 34308 Da
Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3
and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the
SMC5:SMC6 heterodimer. Interacts with PJA1. Binds the C-terminus of E2F1 and NGFR (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus. Chromosome, telomere (Probable)
Sequence caution: Sequence=BAB84964.1; Type=Frameshift; Positions=290;
1 PDB 3D structure from and Proteopedia for NDNL2:
3NW0 (3D)    
Secondary accessions: Q8IW16 Q8TEI6 Q9H214

Explore the universe of human proteins at neXtProt for NDNL2: NX_Q96MG7

Explore proteomics data for NDNL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MG7

  • NDNL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDNL2 Protein Expression
    REFSEQ proteins: NP_619649.1  
    ENSEMBL proteins: 
     ENSP00000330694  

    Human Recombinant Protein Products for NDNL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NDNL2
    GenScript Custom Purified and Recombinant Proteins Services for NDNL2
    Novus Biologicals NDNL2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NDNL2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030915Smc5-Smc6 complex IDA18086888

    NDNL2 for ontologies           About GeneDecksing



    NDNL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NDNL2
    GenScript Custom Superior Antibodies Services for NDNL2
    Novus Biologicals NDNL2 Antibodies
    Search for Antibodies for NDNL2 at Abcam
    Cloud-Clone Corp. Antibodies for NDNL2 
    ThermoFisher Antibodies for NDNL2
    LSBio Antibodies in human, mouse, rat for NDNL2 

    Assay Products for NDNL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDNL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDNL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NDNL2 
    Cloud-Clone Corp. CLIAs for NDNL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q96MG7

    ProtoNet protein and cluster: Q96MG7

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGG1_HUMAN, Q96MG7
    Similarity: Contains 1 MAGE domain


    NDNL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGG1_HUMAN, Q96MG7
    Function: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
    homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
    SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
    recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
    complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
    bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or
    stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that
    facilitates the entry of the cell into cell cycle arrest

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18086888
         
    NDNL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDNL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDNL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDNL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDNL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDNL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NDNL2
    SwitchGear 3'UTR luciferase reporter plasmidNDNL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDNL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDNL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDNL2
    Sirion Biotech Customized adenovirus for overexpression of NDNL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NDNL2 (see all 5)
    OriGene ORF clones in mouse, rat for NDNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDNL2 (NM_138704)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDNL2
    Sirion Biotech Customized lentivirus for stable overexpression of NDNL2 
                         Customized lentivirus expression plasmids for stable overexpression of NDNL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDNL2
    Search LifeMap BioReagents cell lines for NDNL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDNL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling


    1 BioSystems Pathway for NDNL2
        p75(NTR)-mediated signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDNL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for NDNL2 (Q96MG71, 3 ENSP000003306944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010943, ENSP000003455714I2D: score=4 STRING: ENSP00000345571
    NGFRP081383, ENSP000001722294I2D: score=3 STRING: ENSP00000172229
    NSMCE1Q8WV221, ENSP000003550774EBI-2557356,EBI-2557372 STRING: ENSP00000355077
    NSMCE4AQ9NXX61, ENSP000003580194EBI-2557356,EBI-2557393 STRING: ENSP00000358019
    PJA1Q8NG271, ENSP000003550144EBI-2557356,EBI-714606 STRING: ENSP00000355014
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0031398positive regulation of protein ubiquitination IDA--
    GO:0040008regulation of growth IEA--

    NDNL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDNL2 (MAGG1)

    Search CenterWatch for drugs/clinical trials and news about NDNL2 / MAGG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDNL2 gene: 
    NM_138704.3  

    Unigene Cluster for NDNL2:

    Necdin-like 2
    Hs.94011  [show with all ESTs]
    Unigene Representative Sequence: AK074138
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332303(uc001zco.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDNL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NDNL2
    SwitchGear 3'UTR luciferase reporter plasmidNDNL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDNL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDNL2
    Clone
    Products:
         
    OriGene clones in human, mouse for NDNL2 (see all 5)
    OriGene ORF clones in mouse, rat for NDNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDNL2 (NM_138704)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDNL2
    Sirion Biotech Customized lentivirus for stable overexpression of NDNL2 
                         Customized lentivirus expression plasmids for stable overexpression of NDNL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NDNL2
    OriGene qSTAR qPCR primer pairs in human, mouse for NDNL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDNL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDNL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDNL2

    Additional mRNA sequence: 

    AF490510.1 AK056957.1 AK074138.1 BC035458.1 BC041166.1 BC053999.1 

    5 DOTS entries:

    DT.455987  DT.100776249  DT.92423061  DT.100034618  DT.92423059 

    24/131 AceView cDNA sequences (see all 131):

    BQ772383 CR602140 BX102340 BE909407 BQ021505 AA319151 AA953602 BC053999 
    W04542 BC035458 BI759688 CR594488 AK056957 BI759246 AW473739 AI185023 
    CR603768 AI224106 CR592806 AI244558 BI828485 CD742857 BG575782 AA767569 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDNL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCAAGCA
    NDNL2 Expression
    About this image


    See NDNL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDNL2

    SOURCE GeneReport for Unigene cluster: Hs.94011

    UniProtKB/Swiss-Prot: MAGG1_HUMAN, Q96MG7
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for NDNL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NDNL2
    OriGene qSTAR qPCR primer pairs in human, mouse for NDNL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDNL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDNL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDNL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NDNL2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndnl21 , 5 necdin-like 21, 5 80.94(n)1
    83.81(a)1
      7 (34.77 cM)5
    666471  NM_023239.41  NP_075728.11 
     648670525 
    chicken
    (Gallus gallus)
    Aves NDNL21 necdin-like 2 62.9(n)
    53.04(a)
      100125831  NM_001105064.1  NP_001098534.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    50(a)
    1 → many
    1(205667349-205679701)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    43(a)
    1 → many
    23(13012414-13025121)


    ENSEMBL Gene Tree for NDNL2 (if available)
    TreeFam Gene Tree for NDNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDNL2 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  MAGEF12  
    18/38 SIMAP similar genes for NDNL2 using alignment to 1 protein entry:     MAGG1_HUMAN(see all similar genes):
    MAGEH1    MAGEB16    MAGED1    MAGEF1    TRO    MAGEA11
    MAGEC1    MAGE-B1    MAGEA10    MAGEB1    MAGED2    MAGEE1
    MAGEE2    MAGEA9B    MAGEC2    MAGEA9    MAGEB17    MAGEB18

    NDNL2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NDNL2
    PGOHUM00000241390 PGOHUM00000241840


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NDNL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2751526CNV Loss17911159
    nsv522597CNV Loss19592680
    nsv903747CNV Gain21882294
    nsv527255CNV Gain19592680
    nsv515660CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDNL2
    DNA2.0 Custom Variant and Variant Library Synthesis for NDNL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608243    OMIM disorders: --

    4 diseases for NDNL2:    About MalaCards
    hepatocellular carcinoma    melanoma    prader-willi syndrome    angelman syndrome

    1 disease from the University of Copenhagen DISEASES database for NDNL2:
    Prader-Willi syndrome

    NDNL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDNL2

    Export disorders for NDNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDNL2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NDNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2, 3 Taylor E.M....Lehmann A.R. (2008)
    2. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PubMed id 21364888)1, 2 Hudson J.J....Palecek J. (2011)
    3. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues. (PubMed id 11782285)1, 2 Chibuk T.K.... Wevrick R. (2001)
    7. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. (PubMed id 14593116)1, 9 Kuwako K....Yoshikawa K. (2004)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56160 HGNC: 7677 AceView: NDNL2 Ensembl:ENSG00000185115 euGenes: HUgn56160
    ECgene: NDNL2 H-InvDB: NDNL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDNL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDNL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDNL2 gene:
    Search GeneIP for patents involving NDNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NDNL2  
     OriGene qPCR primer pairs and template standards for NDNL2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDNL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDNL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDNL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDNL2   OriGene Custom Protein Services for NDNL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDNL2
     QIAGEN SeqTarget long-range PCR primers for resequencing NDNL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDNL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDNL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDNL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDNL2
     GenScript Custom Purified and Recombinant Proteins Services for NDNL2 GenScript cDNA clones with any tag delivered in your preferred vector for NDNL2
     GenScript Custom Assay Services for NDNL2 GenScript Custom Superior Antibodies Services for NDNL2
     GenScript Custom overexpressing Cell Line Services for NDNL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NDNL2 promoter
     Search Chromatin IP Primers for NDNL2
     RT2 qPCR Primer Assay in human, mouse, rat NDNL2
     GNC Network for NDNL2
     SABiosciences Custom PCR Arrays for NDNL2
     Search Tocris compounds for NDNL2 (MAGG1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NDNL2 antibodies
     NDNL2 proteins
     Search for Antibodies for NDNL2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NDNL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NDNL2
     Antibodies for NDNL2
     ELISAs for NDNL2
     CLIAs for NDNL2
     Search LifeMap BioReagents cell lines for NDNL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNL2
     SwitchGear 3'UTR luciferase reporter plasmids for NDNL2
     SwitchGear Promoter luciferase reporter plasmids for NDNL2
     ThermoFisher Antibodies for NDNL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDNL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NDNL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDNL2
    Customized:
     lentivirus for stable overexpression of NDNL2
     lentivirus expression plasmids for stable overexpression of NDNL2
     adenovirus for overexpression of NDNL2
     LSBio Antibodies in human, mouse, rat for NDNL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NDNL2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4