Aliases for NDNL2 Gene
External Ids for NDNL2 Gene
Previous GeneCards Identifiers for NDNL2 Gene
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
GeneCards Summary for NDNL2 Gene
NDNL2 (Necdin-Like 2) is a Protein Coding gene. Diseases associated with NDNL2 include hepatocellular carcinoma. Among its related pathways are p75(NTR)-mediated signaling. An important paralog of this gene is MAGED1.
UniProtKB/Swiss-Prot for NDNL2 Gene
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.