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Aliases for NDNL2 Gene

Aliases for NDNL2 Gene

  • Necdin-Like 2, SMC5-SMC6 Complex Component 2 3
  • Hepatocellular Carcinoma-Associated Protein 4 3 4
  • Necdin-Like Protein 2 3 4
  • MAGE-G1 Antigen 3 4
  • Necdin-Like 2 2 3
  • MAGEG1 3 4
  • HCA4 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA4 3
  • Melanoma Antigen, Family G, 1 3
  • Necdin-Like Gene 2 3
  • MAGEL3 3
  • NSMCE3 3
  • NSE3 3

External Ids for NDNL2 Gene

Previous GeneCards Identifiers for NDNL2 Gene

  • GC00U990785
  • GC15U900046
  • GC15M027276
  • GC15M027347
  • GC15M029560
  • GC15M007218

Summaries for NDNL2 Gene

Entrez Gene Summary for NDNL2 Gene

  • The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]

GeneCards Summary for NDNL2 Gene

NDNL2 (Necdin-Like 2, SMC5-SMC6 Complex Component) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and p75(NTR)-mediated signaling. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for NDNL2 Gene

  • Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDNL2 Gene

Genomics for NDNL2 Gene

Regulatory Elements for NDNL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDNL2 Gene

Chromosome:
15
Start:
29,268,149 bp from pter
End:
29,269,829 bp from pter
Size:
1,681 bases
Orientation:
Minus strand

Genomic View for NDNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDNL2 Gene

Proteins for NDNL2 Gene

  • Protein details for NDNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MG7-MAGG1_HUMAN
    Recommended name:
    Melanoma-associated antigen G1
    Protein Accession:
    Q96MG7
    Secondary Accessions:
    • Q8IW16
    • Q8TEI6
    • Q9H214

    Protein attributes for NDNL2 Gene

    Size:
    304 amino acids
    Molecular mass:
    34308 Da
    Quaternary structure:
    • Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Interacts with PJA1. Binds the C-terminus of E2F1 and NGFR (By similarity).
    SequenceCaution:
    • Sequence=BAB84964.1; Type=Frameshift; Positions=290; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDNL2 Gene

neXtProt entry for NDNL2 Gene

Proteomics data for NDNL2 Gene at MOPED

Post-translational modifications for NDNL2 Gene

  • Ubiquitination at Lys 113, Lys 128, and Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for NDNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDNL2 Gene

Domains & Families for NDNL2 Gene

Protein Domains for NDNL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MG7

UniProtKB/Swiss-Prot:

MAGG1_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with NDNL2: view

No data available for Gene Families for NDNL2 Gene

Function for NDNL2 Gene

Molecular function for NDNL2 Gene

UniProtKB/Swiss-Prot Function:
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.

Gene Ontology (GO) - Molecular Function for NDNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18086888
genes like me logo Genes that share ontologies with NDNL2: view

Phenotypes for NDNL2 Gene

genes like me logo Genes that share phenotypes with NDNL2: view

Animal Model Products

miRNA for NDNL2 Gene

miRTarBase miRNAs that target NDNL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDNL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NDNL2 Gene

Localization for NDNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDNL2 Gene

Cytoplasm. Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDNL2 Gene COMPARTMENTS Subcellular localization image for NDNL2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NDNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0030915 Smc5-Smc6 complex IDA 18086888
genes like me logo Genes that share ontologies with NDNL2: view

Pathways & Interactions for NDNL2 Gene

genes like me logo Genes that share pathways with NDNL2: view

Gene Ontology (GO) - Biological Process for NDNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0016925 protein sumoylation TAS --
GO:0031398 positive regulation of protein ubiquitination IDA 20864041
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with NDNL2: view

No data available for SIGNOR curated interactions for NDNL2 Gene

Drugs & Compounds for NDNL2 Gene

No Compound Related Data Available

Transcripts for NDNL2 Gene

mRNA/cDNA for NDNL2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NDNL2 Gene

Necdin-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDNL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDNL2 Gene

No ASD Table

Relevant External Links for NDNL2 Gene

GeneLoc Exon Structure for
NDNL2
ECgene alternative splicing isoforms for
NDNL2

Expression for NDNL2 Gene

mRNA expression in normal human tissues for NDNL2 Gene

Protein differential expression in normal tissues from HIPED for NDNL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Testis (8.4), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDNL2 Gene



SOURCE GeneReport for Unigene cluster for NDNL2 Gene Hs.94011

mRNA Expression by UniProt/SwissProt for NDNL2 Gene

Q96MG7-MAGG1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NDNL2: view

Protein tissue co-expression partners for NDNL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NDNL2 Gene

Orthologs for NDNL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDNL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDNL2 35
  • 80 (n)
  • 84 (a)
NDNL2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDNL2 35
  • 87.06 (n)
  • 87.41 (a)
mouse
(Mus musculus)
Mammalia Ndnl2 35
  • 80.34 (n)
  • 83.09 (a)
Ndnl2 16
Ndnl2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDNL2 35
  • 99.45 (n)
  • 99.01 (a)
rat
(Rattus norvegicus)
Mammalia Ndnl2 35
  • 81.06 (n)
  • 84.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDNL2 35
  • 62.52 (n)
  • 52.07 (a)
MAGE 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndnl2 35
  • 60.09 (n)
  • 55.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4035 35
zebrafish
(Danio rerio)
Actinopterygii ndnl2 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for NDNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDNL2 Gene

ENSEMBL:
Gene Tree for NDNL2 (if available)
TreeFam:
Gene Tree for NDNL2 (if available)

Paralogs for NDNL2 Gene

Pseudogenes.org Pseudogenes for NDNL2 Gene

genes like me logo Genes that share paralogs with NDNL2: view

Variants for NDNL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NDNL2 Gene

Variant ID Type Subtype PubMed ID
nsv522597 CNV Loss 19592680
esv2751526 CNV Loss 17911159
nsv527255 CNV Gain 19592680
nsv903747 CNV Gain 21882294
nsv515660 CNV Gain 19592680

Variation tolerance for NDNL2 Gene

Residual Variation Intolerance Score: 65.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDNL2 Gene

HapMap Linkage Disequilibrium report
NDNL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NDNL2 Gene

Disorders for NDNL2 Gene

Relevant External Links for NDNL2

Genetic Association Database (GAD)
NDNL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDNL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDNL2
genes like me logo Genes that share disorders with NDNL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDNL2 Gene

Publications for NDNL2 Gene

  1. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PMID: 18086888) Taylor E.M. … Lehmann A.R. (Mol. Cell. Biol. 2008) 2 67
  2. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. (PMID: 14593116) Kuwako K. … Yoshikawa K. (J. Biol. Chem. 2004) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for NDNL2 Gene

Sources for NDNL2 Gene

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