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Aliases for NDNF Gene

Aliases for NDNF Gene

  • Neuron-Derived Neurotrophic Factor 2 3 4 5
  • C4orf31 3 4
  • Fibronectin Type-III Domain-Containing Protein C4orf31 3
  • Chromosome 4 Open Reading Frame 31 2
  • NORD 3

External Ids for NDNF Gene

Previous HGNC Symbols for NDNF Gene

  • C4orf31

Previous GeneCards Identifiers for NDNF Gene

  • GC04M121957
  • GC04M121958
  • GC04M121962

Summaries for NDNF Gene

GeneCards Summary for NDNF Gene

NDNF (Neuron-Derived Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include heparin binding and glycosaminoglycan binding.

UniProtKB/Swiss-Prot for NDNF Gene

  • Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDNF Gene

Genomics for NDNF Gene

Regulatory Elements for NDNF Gene

Enhancers for NDNF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDNF on UCSC Golden Path with GeneCards custom track

Promoters for NDNF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDNF on UCSC Golden Path with GeneCards custom track

Genomic Location for NDNF Gene

Chromosome:
4
Start:
121,035,613 bp from pter
End:
121,073,021 bp from pter
Size:
37,409 bases
Orientation:
Minus strand

Genomic View for NDNF Gene

Genes around NDNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDNF Gene

Proteins for NDNF Gene

  • Protein details for NDNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB73-NDNF_HUMAN
    Recommended name:
    Protein NDNF
    Protein Accession:
    Q8TB73
    Secondary Accessions:
    • A8K0Q0
    • Q6UWE5
    • Q9H5P7

    Protein attributes for NDNF Gene

    Size:
    568 amino acids
    Molecular mass:
    64673 Da
    Quaternary structure:
    • Binds heparin and chondroitin sulfate.
    SequenceCaution:
    • Sequence=BAB15573.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15573.1; Type=Frameshift; Positions=364, 435; Evidence={ECO:0000305};

neXtProt entry for NDNF Gene

Proteomics data for NDNF Gene at MOPED

Post-translational modifications for NDNF Gene

Other Protein References for NDNF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NDNF

No data available for DME Specific Peptides for NDNF Gene

Domains & Families for NDNF Gene

Protein Domains for NDNF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDNF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TB73

UniProtKB/Swiss-Prot:

NDNF_HUMAN :
  • Contains 2 fibronectin type-III domains.
Domain:
  • Contains 2 fibronectin type-III domains.
genes like me logo Genes that share domains with NDNF: view

No data available for Gene Families for NDNF Gene

Function for NDNF Gene

Molecular function for NDNF Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
UniProtKB/Swiss-Prot Induction:
Up-regulated by hypoxia (at protein level).
genes like me logo Genes that share phenotypes with NDNF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDNF Gene

Localization for NDNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDNF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDNF Gene COMPARTMENTS Subcellular localization image for NDNF gene
Compartment Confidence
extracellular 5
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NDNF Gene

Pathways & Interactions for NDNF Gene

SuperPathways for NDNF Gene

No Data Available

Interacting Proteins for NDNF Gene

Gene Ontology (GO) - Biological Process for NDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IDA 20969804
GO:0002931 response to ischemia IEA --
GO:0010976 positive regulation of neuron projection development IDA 20969804
GO:0016049 cell growth IDA 20969804
GO:0043524 negative regulation of neuron apoptotic process IDA 20969804
genes like me logo Genes that share ontologies with NDNF: view

No data available for Pathways by source and SIGNOR curated interactions for NDNF Gene

Drugs & Compounds for NDNF Gene

No Compound Related Data Available

Transcripts for NDNF Gene

Unigene Clusters for NDNF Gene

Neuron-derived neurotrophic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDNF Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for NDNF Gene

GeneLoc Exon Structure for
NDNF
ECgene alternative splicing isoforms for
NDNF

Expression for NDNF Gene

mRNA expression in normal human tissues for NDNF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDNF Gene

This gene is overexpressed in Lung (x9.4) and Ovary (x6.3).

Protein differential expression in normal tissues from HIPED for NDNF Gene

This gene is overexpressed in Amniocyte (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NDNF Gene



SOURCE GeneReport for Unigene cluster for NDNF Gene Hs.709520

genes like me logo Genes that share expression patterns with NDNF: view

Protein tissue co-expression partners for NDNF Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NDNF Gene

Orthologs for NDNF Gene

This gene was present in the common ancestor of animals.

Orthologs for NDNF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDNF 35
  • 87.73 (n)
  • 93.66 (a)
C6H4ORF31 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDNF 35
  • 90.11 (n)
  • 95.3 (a)
NDNF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndnf 35
  • 85.61 (n)
  • 87.95 (a)
Ndnf 16
Ndnf 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDNF 35
  • 99.24 (n)
  • 99.82 (a)
NDNF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndnf 35
  • 84.59 (n)
  • 85.79 (a)
oppossum
(Monodelphis domestica)
Mammalia NDNF 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDNF 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDNF 35
  • 80.6 (n)
  • 91.17 (a)
NDNF 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDNF 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndnf 35
  • 76.86 (n)
  • 85.61 (a)
Str.14053 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24158 35
zebrafish
(Danio rerio)
Actinopterygii ndnf 35
  • 70.52 (n)
  • 79.96 (a)
ndnf 36
  • 77 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndnf-1 36
  • 21 (a)
OneToOne
Species with no ortholog for NDNF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDNF Gene

ENSEMBL:
Gene Tree for NDNF (if available)
TreeFam:
Gene Tree for NDNF (if available)

Paralogs for NDNF Gene

No data available for Paralogs for NDNF Gene

Variants for NDNF Gene

Sequence variations from dbSNP and Humsavar for NDNF Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs882045 -- 121,061,581(+) TTCTC(A/G)TGTCT intron-variant
rs882046 -- 121,061,859(+) TGATC(A/G)GCTTT intron-variant
rs1045080 -- 121,035,896(-) TCTCT(A/G)TAGAT utr-variant-3-prime
rs1397645 -- 121,036,579(+) GTGGC(A/C/G/T)GAGGA reference, synonymous-codon
rs1397646 -- 121,050,629(+) ACCCA(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDNF Gene

Variant ID Type Subtype PubMed ID
nsv879859 CNV Gain 21882294
nsv507193 CNV Insertion 20534489
esv2656850 CNV Deletion 23128226

Variation tolerance for NDNF Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NDNF Gene

Disorders for NDNF Gene

Relevant External Links for NDNF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDNF

No disorders were found for NDNF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDNF Gene

Publications for NDNF Gene

  1. Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development. (PMID: 20969804) Kuang X.L. … Sun G.T. (BMC Neurosci. 2010) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3
  4. Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes. (PMID: 24706764) Ohashi K. … Ouchi N. (J. Biol. Chem. 2014) 3
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3

Products for NDNF Gene

Sources for NDNF Gene

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