NDNF Gene
protein-coding GIFtS : 40
GCID: GC04 M121957
neuron-derived neurotrophic factor (Previous name: chromosome 4 open reading frame 31 ) (Previous symbol: C4orf31 )
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Aliasesfor NDNF gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Neuron-Derived Neurotrophic Factor 1 2 3 C4orf311 2 3 FLJ231911 Chromosome 4 Open Reading Frame 311 Fibronectin Type-III Domain-Containing Protein C4orf312 Protein NDNF2
Export aliases for NDNF gene to outside databases
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Summariesfor NDNF gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: NDNF_HUMAN, Q8TB73 Function : Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth andsurvival as well as neurite outgrowth
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Genomic Viewsfor NDNF gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for NDNF Other transcription factors Search SABiosciences Chromatin IP Primers for NDNF Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NDNF
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27 NDNF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M121957: view genomic region
(about GC identifiers )
Start:
121,956,768 bp from pter
End:
121,994,176 bp from pter
Size:
37,409 bases
Orientation:
minus strand
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Proteinsfor NDNF gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NDNF_HUMAN, Q8TB73 (See
protein sequence )Recommended Name: Protein NDNF precursor Size : 568 amino acids; 64673 Da
Subunit : Binds heparin and chondroitin sulfate (By similarity)
Subcellular location : Secreted
Sequence caution : Sequence=BAB15573.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB15573.1; Type=Frameshift; Positions=364, 435;
Secondary accessions : A8K0Q0 Q6UWE5 Q9H5P7Explore the universe of human proteins at neXtProt for NDNF: NX_Q8TB73 Post-translational modifications:
O-glycosylated; contains heparan sulfate and chondroitin sulfate (By similarity)1
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TB73 NDNF Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_078850.3 ENSEMBL proteins: ENSP00000369014 ENSP00000423352 ENSP00000426723 Human Recombinant Protein Products for NDNF: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IDA -- GO:0031012 extracellular matrix
ISS --
NDNF for ontologies About GeneDecksing NDNF Antibody Products: Assay Products for NDNF:
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Protein
Domains / Familiesfor NDNF gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NDNF for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TB73 ProtoNet protein and cluster: Q8TB73
UniProtKB/Swiss-Prot: NDNF_HUMAN, Q8TB73 Similarity : Contains 2 fibronectin type-III domains
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Functionfor NDNF gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: NDNF_HUMAN, Q8TB73 Function : Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth andsurvival as well as neurite outgrowth
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005539 glycosaminoglycan binding
ISS -- GO:0008201 heparin binding
ISS --
NDNF for ontologies About GeneDecksing Phenotypes: 1 MGI phenotypic allele for Ndnf (no phenotypes)
NDNF for phenotypes About GeneDecksing Animal Models: Mouse knock-out Ndnf tm1Lex for NDNFClone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for NDNF Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDNF Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NDNF
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNF
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Pathways & Interactionsfor NDNF gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDNF Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001764 neuron migration
IDA -- GO:0010811 positive regulation of cell-substrate adhesion
ISS -- GO:0010976 positive regulation of neuron projection development
IDA -- GO:0016049 cell growth
IDA -- GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
ISS --
NDNF for ontologies About GeneDecksing
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Drugs & Compoundsfor NDNF gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NDNF Search CenterWatch for drugs/clinical trials and news about NDNF
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Transcriptsfor NDNF gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for NDNF gene: NM_024574.3 Unigene Cluster for NDNF:
Neuron-derived neurotrophic factor Hs.709520 [show with all ESTs ] Unigene Representative Sequence: NM_024574 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000379692 (uc003idq.1 ) ENST00000506900 ENST00000515757 ENST00000511408 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for NDNF DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDNF Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NDNF
Additional cDNA sequence: AK026844.1 AK289615.1 AY358821.1 BC019351.1
3 DOTS entries : DT.111340 DT.95338983
DT.100694572 24/63 AceView cDNA sequences (see all 63 ):
BM714644 CA397262 BM725519 AA453143 CR593973 AI245420 AI492491 BP369424 BU739276 AA010797 BQ774423 BP344718 BM554196 AW662834 BI491602 BX370023 BQ894004 W20402 NM_024574 BX370024 AA953484 BU741776 BE503717 BQ015985 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for NDNF About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d SP1 :   -   -   -       -   -           SP2 :       -       -   -           SP3 :             -   -           SP4 :                        
ECgene alternative splicing isoforms for NDNF
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Expression for NDNF gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NDNF expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACATAAAATAbout this image NDNF expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See NDNF Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NDNF SOURCE GeneReport for Unigene cluster: Hs.709520 SABiosciences Custom PCR Arrays for NDNF Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NDNFBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NDNF QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NDNF QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NDNF In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNF
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Orthologsfor NDNF gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for NDNF gene from 7/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for NDNF (if available)TreeFam Gene Tree for NDNF (if available)
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Paralogsfor NDNF gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor NDNF gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 4 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NDNF (121956768 - 121994176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NDNF: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NDNF
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Disorders
/ Diseasesfor NDNF gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NDNF for disorders About GeneDecksing 3 diseases for NDNF : About MalaCards neuronitis alcohol dependence alcoholism Export disorders for NDNF gene to outside databases
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Publicationsfor NDNF gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NDNF gene integrated from 9 sources : (articles sorted by number of sources associating them with NDNF) Utopia : connect your pdf to the dynamic world of online information
Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development. (PubMed id 20969804) 1 , 2 , 3 Kuang X.L....Sun G.T. (2010) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099) 1 Kalsi G....Riley B.P. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Mosaicism for terminal deletion of 4q. (PubMed id 16970039) 1 Utine G.E. and Aktas D. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NDNF gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NDNF gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NDNF gene
(According to HUGE )
About This Section --
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Specialized Databases showing NDNF gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NDNF Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NDNF gene: Search GeneIP for patents involving NDNF GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NDNF gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NDNF OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NDNF OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NDNF OriGene Protein Over-expression Lysate for NDNF Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NDNF OriGene 3'-UTR Clone for NDNF OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NDNF Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for NDNF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NDNF OriGene Custom Protein Services for NDNF OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDNF QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NDNF QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NDNF QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NDNF QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NDNF QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NDNF
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NDNF Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDNF
ThermoFisher Antibodies for NDNF
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NDNF
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