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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDN Gene

protein-coding   GIFtS: 57
GCID: GC15M023931

necdin, melanoma antigen (MAGE) family member

(Previous names: necdin (mouse) homolog, necdin homolog (mouse) )
 Explore 23 diseases affiliated with
NDN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDN    

Aliases
for NDN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Necdin, Melanoma Antigen (MAGE) Family Member1 2     Necdin Homolog (Mouse)1
HsT163281 2     Necdin1
PWCR1 2     Necdin Homolog2
Necdin (Mouse) Homolog1     Prader-Willi Syndrome Chromosome Region2

External Ids:    HGNC: 76751   Entrez Gene: 46922   Ensembl: ENSG000001826367   OMIM: 6021175   UniProtKB: Q996083   

Export aliases for NDN gene to outside databases

Previous GC identifers: GC15M021066 GC15M016820 GC15M021348 GC15M021477 GC15M021481 GC15M002066


Summaries
for NDN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NDN:
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed
exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress
growth in postmitotic neurons. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the
retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T
antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive
manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich
DNA sequences (By similarity)

Gene Wiki entry for NDN


Genomic Views
for NDN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_026446.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDN gene promoter:
         AML1a   Lmo2   MyoD   E47   AREB6   Hand1   STAT3   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDN promoter sequence
   Search SABiosciences Chromatin IP Primers for NDN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2-q12   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11-q12

NDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M023931:  view genomic region     (about GC identifiers)

Start:
 23,930,554 bp from pter      End:
 23,932,450 bp from pter
Size:
 1,897 bases      Orientation:
 minus strand

Proteins
for NDN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608 (See protein sequence)
Recommended Name: Necdin  
Size: 321 amino acids; 36086 Da
Subunit: Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A.
Interacts with nucleobindin 1 and 2 (By similarity)
Subcellular location: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons
and interacts with the nuclear matrix
Miscellaneous: Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous gene
syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and possibly
other genes within the chromosome region 15q11-q13
Secondary accessions: B2R6Z5

Explore the universe of human proteins at neXtProt for NDN: NX_Q99608

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99608

    • NDN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002478.1  
    ENSEMBL proteins: 
     ENSP00000332643  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NDN
    OriGene Protein Over-expression Lysate: NDN
    OriGene Custom Protein Services for NDN 
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    Novus Biologicals NDN Protein
    Novus Biologicals NDN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NDN

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005829cytosol IEA--
    GO:0042995cell projection IEA--


    NDN for ontologies           About GeneDecksing



    NDN Antibody Products: 
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    ThermoFisher Antibodies for NDN

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    Uscn ELISAs and CLIAs for NDN

    Protein Domains /
    Families
    for NDN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q99608

    ProtoNet protein and cluster: Q99608

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Similarity: Contains 1 MAGE domain


    Function
    for NDN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the
    retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T
    antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive
    manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich
    DNA sequences (By similarity)

         Genatlas biochemistry entry for NDN:
    necdin,nuclear protein,predominantly expressed in brain (post-mitotic neurons) and placenta,maternally imprinted
    (paternally expressed) post mitotic neuron-specific growth suppressor with TP53 and modulating its function,also
    interacting with viral transforming proteins and cellular transcription factor E2F1,deleted in PWCR,growth
    suppressor,putatively involved in PWCR neonatal phenotype

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NDN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDN (see all 7)
    OriGene shRNA RFP: NDN
    OriGene siRNA: NDN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NDN

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDN (see all 3)
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    GenScript: all cDNA clones in your preferred vector: NDN (NM_002487)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NDN
    Search LifeMap BioReagents cell lines for NDN

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDN

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0043015gamma-tubulin binding IEA--


    NDN for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NDN:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for NDN: Ndntm1.1Mus Ndntm1Ky Ndntm1Mus
         10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ndn):
     behavior/neurological  cellular  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  no phenotypic analysis  normal  respiratory system 

    NDN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NDN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adipogenesis
    		Adipogenesis1.00
    2p75(NTR)-mediated signaling
    		p75(NTR)-mediated signaling1.00
    3Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NDN
        Transcription factors in neurogenesis


    2 BioSystems Pathways for NDN 
        Adipogenesis
    p75(NTR)-mediated signaling



    NDN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for NDN (Q996082, 3 ENSP000003326434) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSEP516902, 3, ENSP000003705264MINT-64340 I2D: score=5 STRING: ENSP00000370526
    E2F1Q010943, ENSP000003455714I2D: score=5 STRING: ENSP00000345571
    NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    CERS2Q96G233, ENSP000002716884I2D: score=2 STRING: ENSP00000271688
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0003016respiratory system process IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007399nervous system development TAS9630521


    NDN for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NDN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDN
    2 Novoseek chemical compound relationships for NDN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 33 3 19626646 (1)
    tyrosine 0 2 16049186 (1)

    Search CenterWatch for drugs/clinical trials and news about NDN / NECD 

    Transcripts
    for NDN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDN gene: 
    NM_002487.2  

    Unigene Cluster for NDN:

    Necdin, melanoma antigen (MAGE) family member
    Hs.50130  [show with all ESTs]
    Unigene Representative Sequence: NM_002487
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331837(uc001ywk.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NDN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDN (see all 7)
    OriGene shRNA RFP: NDN
    OriGene siRNA: NDN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDN
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NDN (NM_002487)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDN

    Additional cDNA sequence: 

    AK129654.1 AK312779.1 BC008750.1 U35139.1 

    6 DOTS entries:

    DT.114598  DT.95133801  DT.99967699  DT.100645823  DT.100643517  DT.100688217 

    24/211 AceView cDNA sequences (see all 211):

    CR590944 BM127641 N92700 AI081491 CR590044 BQ883698 CR595233 AI559612 
    BU689402 CR599213 AI565179 CR611314 BM970486 AL576276 CR596254 CR626299 
    CR621492 AI624924 AI290417 BM974862 BI823845 CR597888 CR595786 CR609537 

    GeneLoc Exon Structure


    Expression
    for NDN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTTGCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NDN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NDN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDN

    SOURCE GeneReport for Unigene cluster: Hs.50130

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Tissue specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain,
    placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and
    colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons

        SABiosciences Expression via Pathway-Focused PCR Array including NDN: 
              Neurogenesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDN
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDN

    Orthologs
    for NDN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NDN gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 39(a)
    		 1 → many
    		 1(205669616-205678308)
    zebrafish
    (Danio rerio)    		 Actinopterygii ndnl26
    		 necdin-like 2
    		 35(a)
    		 1 → many
    		 23(13012414-13025121)
    fruit fly
    (Drosophila melanogaster)    		 Insecta MAGE6
    		 MAGE
    		 22(a)
    		 1 → many
    		 3R(2979960-2980898)


    ENSEMBL Gene Tree for NDN (if available)
    TreeFam Gene Tree for NDN (if available) 

    Paralogs
    for NDN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDN gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGEE12  
    MAGED12  MAGEA22  MAGEC32  MAGEA32  MAGEB22  MAGEB32  MAGED4B2  MAGEE22  
    MAGEA42  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  
    MAGEA112  NDNL22  MAGEF12  
    18/24 SIMAP similar genes for NDN using alignment to 1 protein entry:     NECD_HUMAN(see all similar genes):
    TRO    MAGED2    NDNL2    MAGED1    MAGEA11    MAGEF1
    MAGEB17    MAGEB2    MAGEB4    MAGED4    MAGED4B    MAGEC2
    MAGEE2    MAGE-B1    MAGEA10    MAGEB18    MAGEC1    MAGEL2

    NDN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDN
    PGOHUM00000239858


    Genomic Variants
    for NDN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/70 NCBI SNPs in NDN are shown (see all 70)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136430031,2
    		--2066110(+) ATTAAC/TAGATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs754382491,2
    		C,F,--2066345(+) ACCCTA/CTNNNN 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs558443211,2
    		C--2066500(+) GTGGGA/GTTGTA 1 -- ut310--------
    rs562856541,2
    		C--2067624(+) CTGGAA/GACCAG 2 S F mis10--------
    rs115393811,2
    		C--2067929(-) CCCAAC/TTCCGA 2 N syn11Minor allele frequency- T:0.00NA 2
    rs749020851,2
    		F,--2068588(+) GATAGG/TCTATA 1 -- us2k11Minor allele frequency- T:0.07NA 120
    rs71736631,2
    		C,F,H,--2069660(+) ACAGAC/GTTATT 1 -- us2k19Minor allele frequency- G:0.03NS EA NA 1092
    rs734321861,2
    		C,--2069711(+) TAAATC/ATCCAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs80261431,2
    		C,A,H,--2069948(+) tcccaA/Gctgct 1 -- us2k15Minor allele frequency- G:0.01NS EA WA 418
    rs284205501,2
    		--2069976(+) AGACTC/G/TGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDN (23930554 - 23932450 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NDN: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NDN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDN for disorders           About GeneDecksing

    OMIM gene information: 602117   
    OMIM disorders: 176270  
    20/23 diseases for NDN (see all 23):    About MalaCards
    prader-willi syndrome    sex reversal    autism spectrum disorder    sleep apnea
    angelman syndrome    apnea    neuronitis    hypogonadotropism
    embryonal carcinoma    hypogonadism    retinoblastoma    hypotonia
    scleroderma    lung adenocarcinoma    ovarian carcinoma    melanoma
    adenocarcinoma    carcinoma    cholesterol    hypoxia

    3 diseases from the University of Copenhagen DISEASES database for NDN:
    Prader-Willi syndrome     Angelman syndrome     Embryonal carcinoma

    9 Novoseek disease relationships for NDN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prader-willi syndrome 91.9 20 18272695 (3), 14593116 (2), 18570257 (2), 9630521 (2) (see all 13)
    angelman syndrome 70.6 1 14593116 (1)
    carcinoma embryonal 64.7 5 15272023 (1), 19626646 (1), 2069569 (1)
    retinoblastoma 29.1 2 10802339 (1), 11302683 (1)
    autistic 26.7 3 11782285 (1), 14593116 (1)
    melanoma 13 1 15272023 (1)
    congenital malformation 10.3 1 15908455 (1)
    tumors 0 6 19626646 (5), 18759029 (1)
    cancer 0 2 19116252 (1), 19626646 (1)

    Genetic Association Database (GAD): NDN
    Human Genome Epidemiology (HuGE) Navigator: NDN (6 documents)

    Export disorders for NDN gene to outside databases

    Publications
    for NDN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDN gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with NDN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. (PubMed id 9354807)1, 2, 9 Jay P.... Muscatelli F. (1997)
    2. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. (PubMed id 9302265)1, 3, 9 MacDonald H.R. and Wevrick R. (1997)
    3. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. (PubMed id 9630521)1, 2, 9 Nakada Y.... Yoshikawa K. (1998)
    4. Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation. (PubMed id 11439287)1, 4, 9 Oeffner F....Grzeschik K.H. (2001)
    5. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. (PubMed id 21543378)1, 2 Beneduzzi D....Latronico A.C. (2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Necdin: a multi functional protein with potential tum or suppressor role? (PubMed id 19626646)1, 9 Chapman E.J. and Knowles M.A. (2009)
    8. Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome. (PubMed id 18272695)1, 9 Zanella S....Hilaire G. (2008)
    9. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. (PubMed id 14593116)1, 9 Kuwako K....Yoshikawa K. (2004)
    10. Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells. (PubMed id 12198120)1, 9 Kobayashi M....Yoshikawa K. (2002)

    External Searches for NDN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4692 HGNC: 7675 AceView: NDN Ensembl:ENSG00000182636 euGenes: HUgn4692
    ECgene: NDN H-InvDB: NDN

    Other Databases showing NDN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NDN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NDN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDN gene:
    Search GeneIP for patents involving NDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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