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NDN Gene

protein-coding   GIFtS: 62
GCID: GC15M023931

Necdin, Melanoma Antigen (MAGE) Family Member

(Previous names: necdin (mouse) homolog, necdin homolog (mouse))
  See NDN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Necdin, Melanoma Antigen (MAGE) Family Member1 2     HsT163282
Prader-Willi Syndrome Chromosome Region1 2     PWCR2
Necdin (Mouse) Homolog1     necdin2
Necdin Homolog (Mouse)1     Necdin Homolog2

External Ids:    HGNC: 76751   Entrez Gene: 46922   Ensembl: ENSG000001826367   OMIM: 6021175   UniProtKB: Q996083   

Export aliases for NDN gene to outside databases

Previous GC identifers: GC15M021066 GC15M016820 GC15M021348 GC15M021477 GC15M021481 GC15M002066


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDN Gene:
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is
expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene
may suppress growth in postmitotic neurons. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDN Gene:
NDN (necdin, melanoma antigen (MAGE) family member) is a protein-coding gene. Diseases associated with NDN include prader-willi syndrome due to paternal deletion of 15q11q13 type 2, and prader-willi syndrome due to imprinting mutation. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to
the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40
large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an
additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific
guanosine-rich DNA sequences (By similarity)

Gene Wiki entry for NDN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDN gene promoter:
         AML1a   Lmo2   MyoD   E47   AREB6   Hand1   STAT3   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDN promoter sequence
   Search Chromatin IP Primers for NDN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2-q12   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11-q12

NDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M023931:  view genomic region     (about GC identifiers)

Start:
23,930,554 bp from pter      End:
23,932,450 bp from pter
Size:
1,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608 (See protein sequence)
Recommended Name: Necdin  
Size: 321 amino acids; 36086 Da
Subunit: Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A.
Interacts with nucleobindin 1 and 2 (By similarity)
Miscellaneous: Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous
gene syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and
possibly other genes within the chromosome region 15q11-q13
Secondary accessions: B2R6Z5

Explore the universe of human proteins at neXtProt for NDN: NX_Q99608

Explore proteomics data for NDN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223, Lys272
  • Modification sites at PhosphoSitePlus

  • See NDN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002478.1  
    ENSEMBL proteins: 
     ENSP00000332643  

    NDN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NDN

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q99608

    ProtoNet protein and cluster: Q99608

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Similarity: Contains 1 MAGE domain


    Find genes that share domains with NDN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECD_HUMAN, Q99608
    Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to
    the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40
    large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an
    additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific
    guanosine-rich DNA sequences (By similarity)

         Genatlas biochemistry entry for NDN:
    necdin,nuclear protein,predominantly expressed in brain (post-mitotic neurons) and placenta,maternally imprinted
    (paternally expressed) post mitotic neuron-specific growth suppressor with TP53 and modulating its function,also
    interacting with viral transforming proteins and cellular transcription factor E2F1,deleted in PWCR,growth
    suppressor,putatively involved in PWCR neonatal phenotype

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0043015gamma-tubulin binding IEA--
         
    Find genes that share ontologies with NDN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NDN:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ndn):
     behavior/neurological  cellular  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  no phenotypic analysis  normal  respiratory system 

    Find genes that share phenotypes with NDN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NDN: Ndntm1.1Mus Ndntm1Ky Ndntm1Mus

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDN

    miRNA
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    miRTarBase miRNAs that target NDN:
    hsa-mir-148b-3p (MIRT019333)

    Block miRNA regulation of human, mouse, rat NDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NDN
    Predesigned siRNA for gene silencing in human, mouse, rat NDN

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for NDN
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    GenScript: all cDNA clones in your preferred vector: NDN (NM_002487)
    Sino Biological Human cDNA Clone for NDN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDN

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NECD_HUMAN, Q99608: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic
    neurons and interacts with the nuclear matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005829cytosol IEA--
    GO:0042995cell projection IEA--

    Find genes that share ontologies with NDN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDN About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling
    3Adipogenesis
    Adipogenesis


    2 BioSystems Pathways for NDN
        Adipogenesis
    p75(NTR)-mediated signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including NDN: 
              Neurogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NDN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDN (Q996082, 3 ENSP000003326434) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSEP516902, 3, ENSP000003705264MINT-64340 I2D: score=5 STRING: ENSP00000370526
    E2F1Q010943, ENSP000003455714I2D: score=5 STRING: ENSP00000345571
    NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    CERS2Q96G233, ENSP000002716884I2D: score=2 STRING: ENSP00000271688
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0003016respiratory system process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007399nervous system development TAS9630521

    Find genes that share ontologies with NDN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDN (NECD)

    2 Novoseek inferred chemical compound relationships for NDN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 33 3 19626646 (1)
    tyrosine 0 2 16049186 (1)



    Find genes that share compounds with NDN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDN gene: 
    NM_002487.2  

    Unigene Cluster for NDN:

    Necdin, melanoma antigen (MAGE) family member
    Hs.50130  [show with all ESTs]
    Unigene Representative Sequence: NM_002487
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331837(uc001ywk.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDN
    Clone
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    GenScript: all cDNA clones in your preferred vector: NDN (NM_002487)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDN
      QuantiTect SYBR Green Assays in human, mouse, rat NDN
      QuantiFast Probe-based Assays in human, mouse, rat NDN

    Additional mRNA sequence: 

    AK129654.1 AK312779.1 BC008750.1 U35139.1 

    6 DOTS entries:

    DT.114598  DT.95133801  DT.99967699  DT.100645823  DT.100643517  DT.100688217 

    Selected AceView cDNA sequences (see all 211):

    BM701605 BU848649 BC008750 F11033 BQ879183 CA446453 AI624924 AI095761 
    N92700 CR616323 BM924919 BM974862 CR626299 BU077982 CR599213 BM973862 
    AI559612 CR618583 CR618894 CR614412 CR618136 CR595786 CR593341 AI081491 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTGCTGG
    NDN Expression
    About this image


    NDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    NDN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50130

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Tissue specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain,
    placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small
    intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons

        Pathway & Disease-focused RT2 Profiler PCR Array including NDN: 
              Neurogenesis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NDN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NDN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndn1 , 5 necdin1, 5 85.25(n)1
    83.18(a)1
      7 (34.36 cM)5
    179841  NM_010882.31  NP_035012.21 
     623482775 
    chicken
    (Gallus gallus)
    Aves MAGE6
    Gallus gallus necdin-like 2 (NDNL2), mRNA.
    35(a)
    1 → many
    JH376257.1(2550-4829)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    1(205667349-205679701)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    34(a)
    1 → many
    23(13012414-13025121) ENSDARG00000058212


    ENSEMBL Gene Tree for NDN (if available)
    TreeFam Gene Tree for NDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDN gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for NDN using alignment to 1 protein entry:     NECD_HUMAN(see all similar genes):
    TRO    NDNL2    MAGED2    MAGED1    MAGEA11    MAGEF1
    MAGEB17    MAGEB2    MAGEB4    MAGED4    MAGED4B    MAGEC2
    MAGEE2    MAGE-B1    MAGEA10    MAGEB18    MAGEC1    MAGEL2

    Find genes that share paralogs with NDN           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NDN
    PGOHUM00000239858


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDN (see all 100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397675991,2
    --3924643(+) TTTTTC/GTATGT 1 -- ds50010--------
    rs1453184431,2
    --3924656(+) GGCCCA/GTGAAC 1 -- ds50010--------
    rs1449924431,2
    --3924733(+) CGGGGC/TATAGG 1 -- ds50010--------
    rs1903715491,2
    --3924811(+) CTCTTA/GTTAAC 1 -- ds50010--------
    rs1136430031,2
    F--3924994(+) ATTAAC/TAGATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1421785931,2
    C--3925067(+) TTTTTA/GTTCCC 1 -- ut310--------
    rs1825861521,2
    --3925173(+) CAATAC/GAACTA 1 -- ut310--------
    rs754382491,2
    C,F--3925229(+) ACCCTA/CTTAGG 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs1869643891,2
    --3925240(+) GGAAAC/TAGTTG 1 -- ut310--------
    rs1913842081,2
    --3925378(+) CTCACA/GGTGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NDN (23930554 - 23932450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NDN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv903596CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDN
    DNA2.0 Custom Variant and Variant Library Synthesis for NDN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602117   
    OMIM disorders: 176270  
    7 diseases for NDN:    
    About MalaCards
    prader-willi syndrome due to paternal deletion of 15q11q13 type 2    prader-willi syndrome due to imprinting mutation    prader-willi syndrome due to maternal uniparental disomy of chromosome 15    prader-willi syndrome due to paternal deletion of 15q11q13 type 1
    prader-willi syndrome    angelman syndrome    autism spectrum disorder

    3 diseases from the University of Copenhagen DISEASES database for NDN:
    Prader-Willi syndrome     Angelman syndrome     Embryonal carcinoma

    Find genes that share disorders with NDN           About GenesLikeMe

    9 Novoseek inferred disease relationships for NDN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prader-willi syndrome 91.9 20 18272695 (3), 14593116 (2), 18570257 (2), 9630521 (2) (see all 13)
    angelman syndrome 70.6 1 14593116 (1)
    carcinoma embryonal 64.7 5 15272023 (1), 19626646 (1), 2069569 (1)
    retinoblastoma 29.1 2 10802339 (1), 11302683 (1)
    autistic 26.7 3 11782285 (1), 14593116 (1)
    melanoma 13 1 15272023 (1)
    congenital malformation 10.3 1 15908455 (1)
    tumors 0 6 19626646 (5), 18759029 (1)
    cancer 0 2 19116252 (1), 19626646 (1)

    Genetic Association Database (GAD): NDN
    Human Genome Epidemiology (HuGE) Navigator: NDN (6 documents)

    Export disorders for NDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDN gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with NDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. (PubMed id 9354807)1, 2, 9 Jay P.... Muscatelli F. (Nat. Genet. 1997)
    2. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. (PubMed id 9302265)1, 3, 9 MacDonald H.R. and Wevrick R. (Hum. Mol. Genet. 1997)
    3. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. (PubMed id 9630521)1, 2, 9 Nakada Y.... Yoshikawa K. (Gene 1998)
    4. Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation. (PubMed id 11439287)1, 4, 9 Oeffner F....Grzeschik K.H. (Int. J. Obes. Relat. Metab. Disord. 2001)
    5. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. (PubMed id 21543378)1, 2 Beneduzzi D....Latronico A.C. (Eur. J. Endocrinol. 2011)
    6. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (Am. J. Respir. Crit. Care Med. 2010)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Necdin: a multi functional protein with potential tumor suppressor role? (PubMed id 19626646)1, 9 Chapman E.J. and Knowles M.A. (Mol. Carcinog. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4692 HGNC: 7675 AceView: NDN Ensembl:ENSG00000182636 euGenes: HUgn4692
    ECgene: NDN H-InvDB: NDN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDN gene:
    Search GeneIP for patents involving NDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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