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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDN Gene

protein-coding   GIFtS: 61
GCID: GC15M023931

Necdin, Melanoma Antigen (MAGE) Family Member

(Previous names: necdin (mouse) homolog, necdin homolog (mouse))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Necdin, Melanoma Antigen (MAGE) Family Member1 2     HsT163282
Prader-Willi Syndrome Chromosome Region1 2     PWCR2
Necdin (Mouse) Homolog1     necdin2
Necdin Homolog (Mouse)1     Necdin Homolog2

External Ids:    HGNC: 76751   Entrez Gene: 46922   Ensembl: ENSG000001826367   OMIM: 6021175   UniProtKB: Q996083   

Export aliases for NDN gene to outside databases

Previous GC identifers: GC15M021066 GC15M016820 GC15M021348 GC15M021477 GC15M021481 GC15M002066


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDN Gene:
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is
expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene
may suppress growth in postmitotic neurons. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDN Gene: 
NDN (necdin, melanoma antigen (MAGE) family member) is a protein-coding gene. Diseases associated with NDN include prader-willi syndrome, and angelman syndrome. GO annotations related to this gene include gamma-tubulin binding and DNA binding. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to
the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40
large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an
additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific
guanosine-rich DNA sequences (By similarity)

Gene Wiki entry for NDN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_026446.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDN gene promoter:
         AML1a   Lmo2   MyoD   E47   AREB6   Hand1   STAT3   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDN promoter sequence
   Search SABiosciences Chromatin IP Primers for NDN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2-q12   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11-q12

NDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M023931:  view genomic region     (about GC identifiers)

Start:
23,930,554 bp from pter      End:
23,932,450 bp from pter
Size:
1,897 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608 (See protein sequence)
Recommended Name: Necdin  
Size: 321 amino acids; 36086 Da
Subunit: Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A.
Interacts with nucleobindin 1 and 2 (By similarity)
Subcellular location: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic
neurons and interacts with the nuclear matrix
Miscellaneous: Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous
gene syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and
possibly other genes within the chromosome region 15q11-q13
Secondary accessions: B2R6Z5

Explore the universe of human proteins at neXtProt for NDN: NX_Q99608

Explore proteomics data for NDN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99608

  • NDN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDN Protein Expression
    REFSEQ proteins: NP_002478.1  
    ENSEMBL proteins: 
     ENSP00000332643  

    Human Recombinant Protein Products for NDN: 
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    Novus Biologicals NDN Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NDN 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005829cytosol IEA--
    GO:0042995cell projection IEA--

    NDN for ontologies           About GeneDecksing



    NDN Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for NDN 

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    Cloud-Clone Corp. CLIAs for NDN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q99608

    ProtoNet protein and cluster: Q99608

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Similarity: Contains 1 MAGE domain


    NDN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECD_HUMAN, Q99608
    Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to
    the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40
    large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an
    additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific
    guanosine-rich DNA sequences (By similarity)

         Genatlas biochemistry entry for NDN:
    necdin,nuclear protein,predominantly expressed in brain (post-mitotic neurons) and placenta,maternally imprinted
    (paternally expressed) post mitotic neuron-specific growth suppressor with TP53 and modulating its function,also
    interacting with viral transforming proteins and cellular transcription factor E2F1,deleted in PWCR,growth
    suppressor,putatively involved in PWCR neonatal phenotype

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0043015gamma-tubulin binding IEA--
         
    NDN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NDN:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ndn):
     behavior/neurological  cellular  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  no phenotypic analysis  normal  respiratory system 

    NDN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NDN: Ndntm1.1Mus Ndntm1Ky Ndntm1Mus

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDN 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling
    2Adipogenesis
    Adipogenesis
    3Transcription factors in neurogenesis
    Transcription factors in neurogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NDN
        Transcription factors in neurogenesis


    2 BioSystems Pathways for NDN
        Adipogenesis
    p75(NTR)-mediated signaling



    NDN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for NDN (Q996082, 3 ENSP000003326434) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSEP516902, 3, ENSP000003705264MINT-64340 I2D: score=5 STRING: ENSP00000370526
    E2F1Q010943, ENSP000003455714I2D: score=5 STRING: ENSP00000345571
    NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    CERS2Q96G233, ENSP000002716884I2D: score=2 STRING: ENSP00000271688
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0003016respiratory system process IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007399nervous system development TAS9630521

    NDN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NDN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDN (NECD)

    2 Novoseek inferred chemical compound relationships for NDN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 33 3 19626646 (1)
    tyrosine 0 2 16049186 (1)

    Search CenterWatch for drugs/clinical trials and news about NDN / NECD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDN gene: 
    NM_002487.2  

    Unigene Cluster for NDN:

    Necdin, melanoma antigen (MAGE) family member
    Hs.50130  [show with all ESTs]
    Unigene Representative Sequence: NM_002487
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331837(uc001ywk.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate NDN (see all 24):
    hsa-miR-217 hsa-miR-429 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-219-5p hsa-miR-513c hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDN 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NDN (NM_002487)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDN
    Sirion Biotech Customized lentivirus for stable overexpression of NDN 
                         Customized lentivirus expression plasmids for stable overexpression of NDN 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDN

    Additional mRNA sequence: 

    AK129654.1 AK312779.1 BC008750.1 U35139.1 

    6 DOTS entries:

    DT.114598  DT.95133801  DT.99967699  DT.100645823  DT.100643517  DT.100688217 

    24/211 AceView cDNA sequences (see all 211):

    CA446453 CR599213 CR611314 CR609537 CR591182 AI566401 CR621492 AI290417 
    AI624924 BM974862 CR622500 CK906224 CR595786 BM127641 N92700 BU848649 
    AW241175 BQ883698 BI823845 AI081491 CR619220 CR597888 CR619365 CR609284 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDN expression in normal human tissues (normalized intensities)      NDN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTGCTGG
    NDN Expression
    About this image


    NDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Substantia Nigra   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor SM22
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See NDN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDN

    SOURCE GeneReport for Unigene cluster: Hs.50130

    UniProtKB/Swiss-Prot: NECD_HUMAN, Q99608
    Tissue specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain,
    placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small
    intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons

        SABiosciences Expression via Pathway-Focused PCR Array including NDN: 
              Neurogenesis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NDN gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndn1 , 5 necdin1, 5 85.05(n)1
    83.18(a)1
      7 (34.36 cM)5
    179841  NM_010882.31  NP_035012.21 
     623482775 
    chicken
    (Gallus gallus)
    Aves MAGE6
    Mage protein
    35(a)
    1 → many
    JH376257.1(2550-4829)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    1 → many
    1(205667349-205679701)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    33(a)
    1 → many
    23(13012414-13025121)


    ENSEMBL Gene Tree for NDN (if available)
    TreeFam Gene Tree for NDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDN gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    18/22 SIMAP similar genes for NDN using alignment to 1 protein entry:     NECD_HUMAN(see all similar genes):
    TRO    MAGED2    NDNL2    MAGED1    MAGEA11    MAGEF1
    MAGEB17    MAGEB2    MAGEB4    MAGED4    MAGED4B    MAGEC2
    MAGEE2    MAGE-B1    MAGEA10    MAGEB18    MAGEC1    MAGEL2

    NDN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDN
    PGOHUM00000239858


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 SNPs in NDN are shown (see all 100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397675991,2
    --3924643(+) TTTTTC/GTATGT 1 -- ds50010--------
    rs1453184431,2
    --3924656(+) GGCCCA/GTGAAC 1 -- ds50010--------
    rs1449924431,2
    --3924733(+) CGGGGC/TATAGG 1 -- ds50010--------
    rs1903715491,2
    --3924811(+) CTCTTA/GTTAAC 1 -- ds50010--------
    rs1136430031,2
    F--3924994(+) ATTAAC/TAGATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1421785931,2
    C--3925067(+) TTTTTA/GTTCCC 1 -- ut310--------
    rs1825861521,2
    --3925173(+) CAATAC/GAACTA 1 -- ut310--------
    rs754382491,2
    C,F--3925229(+) ACCCTA/CTTAGG 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs1869643891,2
    --3925240(+) GGAAAC/TAGTTG 1 -- ut310--------
    rs1913842081,2
    --3925378(+) CTCACA/GGTGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NDN (23930554 - 23932450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NDN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv903596CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602117   
    OMIM disorders: 176270  
    18 diseases for NDN:    About MalaCards
    prader-willi syndrome    angelman syndrome    hypogonadotropism    sleep apnea
    autism spectrum disorder    hypotonia    hypogonadism    retinoblastoma
    lung adenocarcinoma    scleroderma    melanoma    neuronitis
    hypoxia    neuroblastoma    adenocarcinoma    obesity
    thyroiditis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for NDN:
    Prader-Willi syndrome     Angelman syndrome     Embryonal carcinoma

    NDN for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for NDN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prader-willi syndrome 91.9 20 18272695 (3), 14593116 (2), 18570257 (2), 9630521 (2) (see all 13)
    angelman syndrome 70.6 1 14593116 (1)
    carcinoma embryonal 64.7 5 15272023 (1), 19626646 (1), 2069569 (1)
    retinoblastoma 29.1 2 10802339 (1), 11302683 (1)
    autistic 26.7 3 11782285 (1), 14593116 (1)
    melanoma 13 1 15272023 (1)
    congenital malformation 10.3 1 15908455 (1)
    tumors 0 6 19626646 (5), 18759029 (1)
    cancer 0 2 19116252 (1), 19626646 (1)

    Genetic Association Database (GAD): NDN
    Human Genome Epidemiology (HuGE) Navigator: NDN (6 documents)

    Export disorders for NDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDN gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with NDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. (PubMed id 9354807)1, 2, 9 Jay P.... Muscatelli F. (1997)
    2. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. (PubMed id 9302265)1, 3, 9 MacDonald H.R. and Wevrick R. (1997)
    3. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region. (PubMed id 9630521)1, 2, 9 Nakada Y.... Yoshikawa K. (1998)
    4. Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation. (PubMed id 11439287)1, 4, 9 Oeffner F....Grzeschik K.H. (2001)
    5. Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. (PubMed id 21543378)1, 2 Beneduzzi D....Latronico A.C. (2011)
    6. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (2010)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Necdin: a multi functional protein with potential tum or suppressor role? (PubMed id 19626646)1, 9 Chapman E.J. and Knowles M.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4692 HGNC: 7675 AceView: NDN Ensembl:ENSG00000182636 euGenes: HUgn4692
    ECgene: NDN H-InvDB: NDN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDN gene:
    Search GeneIP for patents involving NDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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