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Aliases for NDFIP2 Gene

Aliases for NDFIP2 Gene

  • Nedd4 Family Interacting Protein 2 2 3
  • N4WBP5A 3 4 6
  • Putative MAPK-Activating Protein PM04/PM05/PM06/PM07 3 4
  • Putative NF-Kappa-B-Activating Protein 413 3 4
  • NEDD4 WW Domain-Binding Protein 5A 3 4
  • KIAA1165 4 6
  • MAPK-Activating Protein PM04 PM05 PM06 PM07 3
  • NEDD4 Family-Interacting Protein 2 3
  • NF-Kappa-B-Activating Protein 413 3

External Ids for NDFIP2 Gene

Summaries for NDFIP2 Gene

GeneCards Summary for NDFIP2 Gene

NDFIP2 (Nedd4 Family Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and WW domain binding. An important paralog of this gene is NDFIP1.

UniProtKB/Swiss-Prot for NDFIP2 Gene

  • Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.

Gene Wiki entry for NDFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDFIP2 Gene

Genomics for NDFIP2 Gene

Genomic Location for NDFIP2 Gene

Start:
79,481,098 bp from pter
End:
79,556,077 bp from pter
Size:
74,980 bases
Orientation:
Plus strand

Genomic View for NDFIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDFIP2 Gene

Regulatory Elements for NDFIP2 Gene

Proteins for NDFIP2 Gene

  • Protein details for NDFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV92-NFIP2_HUMAN
    Recommended name:
    NEDD4 family-interacting protein 2
    Protein Accession:
    Q9NV92
    Secondary Accessions:
    • Q7Z2H3
    • Q7Z428
    • Q8TAR3
    • Q9ULQ5

    Protein attributes for NDFIP2 Gene

    Size:
    336 amino acids
    Molecular mass:
    36390 Da
    Quaternary structure:
    • Forms heterodimers with NDFIP1. Interacts with HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4. Interacts with NEDD4L (By similarity). Interacts with PTEN. When phosphorylated at Tyr-167, interacts with SRC and LYN SH2 domain. May thus act as a scaffold that recruits SRC to NDFIP1, enhancing NDFIP1 phosphorylation. Interacts with SLC11A2/DMT1. May interact with phosphorylated EGFR.
    SequenceCaution:
    • Sequence=AAH21988.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH26126.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91863.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NDFIP2 Gene

Proteomics data for NDFIP2 Gene at MOPED

Post-translational modifications for NDFIP2 Gene

  • Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover (By similarity).
  • Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Also phosphorylated by LYN and FYN.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys193

Other Protein References for NDFIP2 Gene

No data available for DME Specific Peptides for NDFIP2 Gene

Domains for NDFIP2 Gene

Protein Domains for NDFIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDFIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV92

UniProtKB/Swiss-Prot:

NFIP2_HUMAN
Domain:
  • The PY/WW-binding motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination:
    • Q9NV92
genes like me logo Genes that share domains with NDFIP2: view

No data available for Gene Families for NDFIP2 Gene

Function for NDFIP2 Gene

Molecular function for NDFIP2 Gene

UniProtKB/Swiss-Prot Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
UniProtKB/Swiss-Prot Induction: By T-cell activation.

Gene Ontology (GO) - Molecular Function for NDFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 18776082
GO:0050699 WW domain binding IPI 12796489
genes like me logo Genes that share ontologies with NDFIP2: view

Phenotypes for NDFIP2 Gene

GenomeRNAi human phenotypes for NDFIP2:
genes like me logo Genes that share phenotypes with NDFIP2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDFIP2 Gene

Localization for NDFIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDFIP2 Gene

Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDFIP2 Gene COMPARTMENTS Subcellular localization image for NDFIP2 gene
Compartment Confidence
endosome 5
golgi apparatus 5
endoplasmic reticulum 4
mitochondrion 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA 12796489
GO:0005739 mitochondrion IDA 12796489
GO:0005768 endosome --
GO:0005783 endoplasmic reticulum IDA 12796489
genes like me logo Genes that share ontologies with NDFIP2: view

Pathways for NDFIP2 Gene

SuperPathways for NDFIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NDFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0010629 negative regulation of gene expression IMP 18776082
GO:0031398 positive regulation of protein ubiquitination IMP 18776082
GO:0032410 negative regulation of transporter activity IMP 18776082
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with NDFIP2: view

No data available for Pathways by source for NDFIP2 Gene

Transcripts for NDFIP2 Gene

Unigene Clusters for NDFIP2 Gene

Nedd4 family interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDFIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - -

Relevant External Links for NDFIP2 Gene

GeneLoc Exon Structure for
NDFIP2
ECgene alternative splicing isoforms for
NDFIP2

Expression for NDFIP2 Gene

mRNA expression in normal human tissues for NDFIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDFIP2 Gene

SOURCE GeneReport for Unigene cluster for NDFIP2 Gene Hs.525093

mRNA Expression by UniProt/SwissProt for NDFIP2 Gene

Q9NV92-NFIP2_HUMAN
Tissue specificity: Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.
genes like me logo Genes that share expressions with NDFIP2: view

No data available for mRNA differential expression in normal tissues for NDFIP2 Gene

Orthologs for NDFIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDFIP2 35
  • 99.38 (n)
  • 99.38 (a)
NDFIP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDFIP2 35
  • 89.38 (n)
  • 86.01 (a)
NDFIP2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDFIP2 35
  • 89.58 (n)
  • 87.81 (a)
NDFIP2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndfip2 35
  • 84.38 (n)
  • 82.09 (a)
Ndfip2 16
Ndfip2 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDFIP2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDFIP2 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndfip2 35
  • 84.82 (n)
  • 83.63 (a)
chicken
(Gallus gallus)
Aves NDFIP2 35
  • 81.12 (n)
  • 84.98 (a)
NDFIP2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDFIP2 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68708 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndfip2 35
  • 76.17 (n)
  • 81.28 (a)
Str.10169 35
zebrafish
(Danio rerio)
Actinopterygii ndfip2 35
  • 70.47 (n)
  • 73.68 (a)
ndfip2 36
  • 71 (a)
OneToOne
wufa92h03 35
fruit fly
(Drosophila melanogaster)
Insecta Ndfip 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for NDFIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDFIP2 Gene

ENSEMBL:
Gene Tree for NDFIP2 (if available)
TreeFam:
Gene Tree for NDFIP2 (if available)

Paralogs for NDFIP2 Gene

Paralogs for NDFIP2 Gene

Selected SIMAP similar genes for NDFIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NDFIP2: view

Variants for NDFIP2 Gene

Sequence variations from dbSNP and Humsavar for NDFIP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs9924 -- 79,554,494(+) TGTTA(C/T)TTTTG utr-variant-3-prime
rs700396 -- 79,553,323(+) ATTTT(A/G)TTTTA utr-variant-3-prime
rs987284 -- 79,549,849(-) CCTCC(G/T)TTTGG intron-variant
rs1044647 -- 79,554,409(+) GGAAG(C/T)TTAGC utr-variant-3-prime
rs1212082 -- 79,552,633(-) AACTC(C/T)GTCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NDFIP2 Gene

Variant ID Type Subtype PubMed ID
nsv832657 CNV Gain 17160897
nsv523979 CNV Loss 19592680
esv2229257 CNV Deletion 18987734
esv2651677 CNV Deletion 19546169
esv8765 CNV Loss 19470904
esv2747709 CNV Deletion 23290073
esv3018 CNV Deletion 18987735
esv1276458 CNV Deletion 17803354
nsv819683 CNV Loss 19587683

Relevant External Links for NDFIP2 Gene

HapMap Linkage Disequilibrium report
NDFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDFIP2 Gene

Disorders for NDFIP2 Gene

(1) University of Copenhagen DISEASES for NDFIP2 Gene

Relevant External Links for NDFIP2

Genetic Association Database (GAD)
NDFIP2
genes like me logo Genes that share disorders with NDFIP2: view

No data available for UniProtKB/Swiss-Prot for NDFIP2 Gene

Publications for NDFIP2 Gene

  1. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PMID: 19343052) Mund T. … Pelham H.R. (EMBO Rep. 2009) 3 4 23
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. (PMID: 12050153) Konstas A.A. … Kumar S. (J. Biol. Chem. 2002) 2 3
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  5. Cloning and characterization of N4WBP5A, an inducible, cyclosporine- sensitive, Nedd4-binding protein in human T lymphocytes. (PMID: 12796489) Cristillo A.D. … Bierer B.E. (J. Biol. Chem. 2003) 3 4

Products for NDFIP2 Gene

Sources for NDFIP2 Gene

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