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NDFIP2 Gene

protein-coding   GIFtS: 54
GCID: GC13P080055

Nedd4 Family Interacting Protein 2

  See NDFIP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nedd4 Family Interacting Protein 21 2     KIAA11653 5
N4WBP5A2 3 5     MAPK-Activating Protein PM04 PM05 PM06 PM072
Putative MAPK-Activating Protein PM04/PM05/PM06/PM072 3     NEDD4 Family-Interacting Protein 22
Putative NF-Kappa-B-Activating Protein 4132 3     NF-Kappa-B-Activating Protein 4132
NEDD4 WW Domain-Binding Protein 5A2 3     

External Ids:    HGNC: 185371   Entrez Gene: 546022   Ensembl: ENSG000001024717   OMIM: 6100415   UniProtKB: Q9NV923   

Export aliases for NDFIP2 gene to outside databases

Previous GC identifers: GC13P074050 GC13P078992 GC13P077853 GC13P078878 GC13P060758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NDFIP2 Gene:
NDFIP2 (Nedd4 family interacting protein 2) is a protein-coding gene. Diseases associated with NDFIP2 include hypochromic anemia. GO annotations related to this gene include WW domain binding and signal transducer activity. An important paralog of this gene is NDFIP1.

UniProtKB/Swiss-Prot: NFIP2_HUMAN, Q9NV92
Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2,
WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular
processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling

Gene Wiki entry for NDFIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDFIP2 gene promoter:
         AhR   C/EBPbeta   AP-1   CUTL1   c-Ets-1   Arnt   RORalpha1   NRF-2   SEF-1 (1)   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDFIP2 promoter sequence
   Search Chromatin IP Primers for NDFIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDFIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q22.1

NDFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDFIP2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P080055:  view genomic region     (about GC identifiers)

Start:
80,055,259 bp from pter      End:
80,130,212 bp from pter
Size:
74,954 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NFIP2_HUMAN, Q9NV92 (See protein sequence)
Recommended Name: NEDD4 family-interacting protein 2  
Size: 336 amino acids; 36390 Da
Subunit: Forms heterodimers with NDFIP1. Interacts with HECT domain-containing E3 ubiquitin-protein ligases,
including NEDD4. Interacts with NEDD4L (By similarity). Interacts with PTEN. When phosphorylated at Tyr-167,
interacts with SRC and LYN SH2 domain. May thus act as a scaffold that recruits SRC to NDFIP1, enhancing NDFIP1
phosphorylation. Interacts with SLC11A2/DMT1. May interact with phosphorylated EGFR
Sequence caution: Sequence=AAH21988.1; Type=Erroneous initiation; Sequence=AAH26126.1; Type=Erroneous initiation;
Sequence=BAA91863.1; Type=Erroneous initiation;
Secondary accessions: Q7Z2H3 Q7Z428 Q8TAR3 Q9ULQ5

Explore the universe of human proteins at neXtProt for NDFIP2: NX_Q9NV92

Explore proteomics data for NDFIP2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect
    turnover (By similarity)1
  • Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Also
    phosphorylated by LYN and FYN1
  • Ubiquitination2 at Lys193
  • Modification sites at PhosphoSitePlus

  • See NDFIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001154879.1  NP_061953.2  

    ENSEMBL proteins: 
     ENSP00000218652   ENSP00000419200   ENSP00000419776  

    NDFIP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NDFIP2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019325 NEDD4/BSD2

    Graphical View of Domain Structure for InterPro Entry Q9NV92

    ProtoNet protein and cluster: Q9NV92

    UniProtKB/Swiss-Prot: NFIP2_HUMAN, Q9NV92
    Domain: The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination


    Find genes that share domains with NDFIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIP2_HUMAN, Q9NV92
    Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2,
    WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular
    processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling
    Induction: By T-cell activation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI18776082
    GO:0050699WW domain binding IPI12796489
         
    Find genes that share ontologies with NDFIP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NDFIP2:
     Upregulation of NF-kappaB path 

         1 MGI phenotypic allele for Ndfip2 (no phenotypes)

    Find genes that share phenotypes with NDFIP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDFIP2
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    miRNA
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    miRTarBase miRNAs that target NDFIP2:
    hsa-mir-31-5p (MIRT049872), hsa-mir-1914-5p (MIRT035788), hsa-mir-378a-3p (MIRT043881), hsa-mir-760 (MIRT036778), hsa-mir-192-5p (MIRT026926), hsa-mir-7-5p (MIRT025956)

    Block miRNA regulation of human, mouse, rat NDFIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDFIP2 (see all 59):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-513a-5p hsa-miR-200a hsa-miR-134 hsa-miR-374c hsa-miR-141 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidNDFIP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDFIP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFIP2_HUMAN, Q9NV92: Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome,
    multivesicular body membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    endoplasmic reticulum4
    mitochondrion4
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA12796489
    GO:0005739mitochondrion IDA12796489
    GO:0005783endoplasmic reticulum IDA12796489
    GO:0005794Golgi apparatus IDA12796489

    Find genes that share ontologies with NDFIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDFIP2
    Interactions:

        GeneGlobe Interaction Network for NDFIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDFIP2 (Q9NV923 ENSP000002186524) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWP2O003083, ENSP000003482834I2D: score=2 STRING: ENSP00000348283
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    ITCHQ96J023, ENSP000003639984I2D: score=1 STRING: ENSP00000363998
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0010629negative regulation of gene expression IMP18776082
    GO:0031398positive regulation of protein ubiquitination IMP18776082
    GO:0032410negative regulation of transporter activity IMP18776082
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with NDFIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDFIP2 (NFIP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDFIP2 gene (2 alternative transcripts): 
    NM_001161407.1  NM_019080.2  

    Unigene Cluster for NDFIP2:

    Nedd4 family interacting protein 2
    Hs.525093  [show with all ESTs]
    Unigene Representative Sequence: NM_019080
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218652(uc010tib.2 uc001vlf.3 uc001vlg.3) ENST00000487865
    ENST00000465762 ENST00000494647
    miRNA
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    Block miRNA regulation of human, mouse, rat NDFIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDFIP2 (see all 59):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-513a-5p hsa-miR-200a hsa-miR-134 hsa-miR-374c hsa-miR-141 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidNDFIP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NDFIP2 (NM_001161407)
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      QuantiTect SYBR Green Assays in human, mouse, rat NDFIP2
      QuantiFast Probe-based Assays in human, mouse, rat NDFIP2

    Additional mRNA sequence: 

    AB032991.1 AB097019.1 AB097028.1 AB097029.1 AB097030.1 AB097031.1 AK001723.1 AK098708.1 
    AK294839.1 AK297197.1 BC021988.1 BC026126.2 

    5 DOTS entries:

    DT.454612  DT.95116329  DT.100708610  DT.120778350  DT.86839933 

    Selected AceView cDNA sequences (see all 242):

    BM976935 AW131246 AI354567 BU151089 AB097029 F13200 BE645561 BQ877564 
    AA508087 AU117365 AW592251 CK904102 BQ681882 BU157279 AI471766 BQ228707 
    F10803 BM989394 BC021988 BQ878884 BE018403 AI742122 BU630777 BQ438996 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NDFIP2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:                    -     -     -                                                         
    SP2:                                -                       -     -                           
    SP3:                    -     -     -                       -                                 
    SP4:                          -                                                               
    SP5:                    -     -     -                                                         


    ECgene alternative splicing isoforms for NDFIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDFIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAACTTAC
    NDFIP2 Expression
    About this image


    NDFIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)
    NDFIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDFIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525093

    UniProtKB/Swiss-Prot: NFIP2_HUMAN, Q9NV92
    Tissue specificity: Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDFIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDFIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndfip21 , 5 Nedd4 family interacting protein 21, 5 84.38(n)1
    82.09(a)1
      14 (55.64 cM)5
    762731  NM_029561.41  NP_083837.21 
     1052585735 
    chicken
    (Gallus gallus)
    Aves NDFIP21 Nedd4 family interacting protein 2 81.12(n)
    84.98(a)
      418803  NM_001030820.1  NP_001025991.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDFIP26
    Nedd4 family interacting protein 2
    71(a)
    1 ↔ 1
    3(96958173-97022742)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687082 hypothetical protein MGC68708 81.82(n)    BC060023.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa92h032 Danio rerio cDNA clone MGC63948 IMAGE6791361, complete more 80.79(n)    BC059183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndfip6
    Nedd4 family interacting protein
    24(a)
    1 → many
    3L(17640542-17647380)


    ENSEMBL Gene Tree for NDFIP2 (if available)
    TreeFam Gene Tree for NDFIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDFIP2 gene
    NDFIP12  
    1 SIMAP similar gene for NDFIP2 using alignment to 3 protein entries:     NFIP2_HUMAN (see all proteins):
    NDFIP1

    Find genes that share paralogs with NDFIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDFIP2 (see all 1307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928545991,2
    --80057453(+) ATTTAC/TGTAGT 2 -- int10--------
    rs768468751,2
    F--80057454(+) TTTACA/GTAGTC 2 -- int10--------
    rs95451261,2
    C,F,H--80057681(+) AAACCA/CCTTGA 2 -- int119Minor allele frequency- C:0.16NS EA NA CSA WA 2362
    rs1838334481,2
    --80057782(+) AAAGAA/GTTTAA 2 -- int10--------
    rs95655091,2
    C,F,H--80057831(+) AGGGTC/TATCAG 2 -- int112Minor allele frequency- N:0.02EA NA NS 846
    rs79841591,2
    C,F,A,H--80057839(+) CAGAAG/TGACTT 2 -- int16Minor allele frequency- T:0.48NS WA CSA 245
    rs79837301,2
    C,F,H--80057879(+) CTAGAA/CACTGC 2 -- int18Minor allele frequency- C:0.04NS EA NA WA 486
    rs79839041,2
    C,F--80057955(+) GGATAA/GCAGTT 2 -- int14Minor allele frequency- G:0.21WA CSA 124
    rs1467891261,2
    --80057994(+) CCTTCC/TAATTT 2 -- int10--------
    rs79842411,2
    C,F,H--80058082(+) TATGAC/TGAAGT 2 -- int18Minor allele frequency- T:0.04NS EA NA WA 506

    HapMap Linkage Disequilibrium report for NDFIP2 (80055259 - 80130212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NDFIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2651677CNV Deletion19546169
    esv2229257CNV Deletion18987734
    esv1276458CNV Deletion17803354
    esv2747709CNV Deletion23290073
    esv3018CNV Deletion18987735
    nsv819683CNV Loss19587683
    esv8765CNV Loss19470904
    nsv523979CNV Loss19592680
    nsv832657CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610041    OMIM disorders: --

    1 disease for NDFIP2:    
    About MalaCards
    hypochromic anemia

    1 disease from the University of Copenhagen DISEASES database for NDFIP2:
    Hypochromic anemia

    Find genes that share disorders with NDFIP2           About GenesLikeMe

    Genetic Association Database (GAD): NDFIP2

    Export disorders for NDFIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDFIP2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NDFIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 1999)
    2. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2, 9 Mund T. and Pelham H.R. (EMBO Rep. 2009)
    3. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (PLoS ONE 2010)
    4. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. (PubMed id 20534535)1, 2 Mund T. and Pelham H.R. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. (PubMed id 18776082)1, 2 Foot N.J.... Kumar S. (Blood 2008)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    10. Cloning and characterization of N4WBP5A, an inducible, cyclosporine- sensitive, Nedd4-binding protein in human T lymphocytes. (PubMed id 12796489)1, 2 Cristillo A.D.... Bierer B.E. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54602 HGNC: 18537 AceView: NDFIP2.1 Ensembl:ENSG00000102471 euGenes: HUgn54602
    ECgene: NDFIP2 H-InvDB: NDFIP2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1165

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDFIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDFIP2 gene:
    Search GeneIP for patents involving NDFIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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