Aliases for NDFIP1 Gene
- Nedd4 Family Interacting Protein 1 2 3
- Putative NF-Kappa-B-Activating Protein 164 3 4
- Putative NFKB And MAPK-Activating Protein 3 4
- Breast Cancer-Associated Protein SGA-1M 3 4
- Putative MAPK-Activating Protein PM13 3 4
- N4WBP5 3 4
- Nedd4 WW Domain-Binding Protein 5 3
- NEDD4 WW Domain-Binding Protein 5 4
External Ids for NDFIP1 Gene
Previous GeneCards Identifiers for NDFIP1 Gene
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDFIP1 Gene
NDFIP1 (Nedd4 Family Interacting Protein 1) is a Protein Coding gene. Diseases associated with NDFIP1 include germ cell cancer. GO annotations related to this gene include signal transducer activity and WW domain binding. An important paralog of this gene is NDFIP2.
UniProtKB/Swiss-Prot for NDFIP1 Gene
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046).