Aliases for NDFIP1 Gene
- Nedd4 Family Interacting Protein 1 2 3 5
- Putative NF-Kappa-B-Activating Protein 164 3 4
- Putative NFKB And MAPK-Activating Protein 3 4
- Breast Cancer-Associated Protein SGA-1M 3 4
- Putative MAPK-Activating Protein PM13 3 4
- N4WBP5 3 4
- Nedd4 WW Domain-Binding Protein 5 3
- NEDD4 WW Domain-Binding Protein 5 4
External Ids for NDFIP1 Gene
Previous GeneCards Identifiers for NDFIP1 Gene
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDFIP1 Gene
NDFIP1 (Nedd4 Family Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and WW domain binding. An important paralog of this gene is NDFIP2.
UniProtKB/Swiss-Prot for NDFIP1 Gene
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046).