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NDFIP1 Gene

protein-coding   GIFtS: 53
GCID: GC05P141489

Nedd4 Family Interacting Protein 1

  See NDFIP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nedd4 Family Interacting Protein 11 2     Putative MAPK-Activating Protein PM132 3
N4WBP52 3 5     Putative NF-Kappa-B-Activating Protein 1642 3
Breast Cancer-Associated Protein SGA-1M2 3     Putative NFKB And MAPK-Activating Protein2 3
NEDD4 WW Domain-Binding Protein 52 3     NEDD4 Family-Interacting Protein 12

External Ids:    HGNC: 175921   Entrez Gene: 807622   Ensembl: ENSG000001315077   OMIM: 6120505   UniProtKB: Q9BT673   

Export aliases for NDFIP1 gene to outside databases

Previous GC identifers: GC05P142071 GC05P141471 GC05P141516 GC05P141468 GC05P136635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDFIP1 Gene:
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three
transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein
is thought to be part of a family of integral Golgi membrane proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDFIP1 Gene:
NDFIP1 (Nedd4 family interacting protein 1) is a protein-coding gene. Diseases associated with NDFIP1 include breast cancer. GO annotations related to this gene include WW domain binding and signal transducer activity. An important paralog of this gene is NDFIP2.

UniProtKB/Swiss-Prot: NFIP1_HUMAN, Q9BT67
Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and
consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents
chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By
similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to
down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity.
Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8
signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through
ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDFIP1 gene promoter:
         E2F-3a   E2F-4   ISGF-3   E2F-5   Pbx1a   Pax-5   E2F-2   E2F-1   E2F   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDFIP1 promoter sequence
   Search Chromatin IP Primers for NDFIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDFIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3

NDFIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDFIP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P141489:  view genomic region     (about GC identifiers)

Start:
141,488,070 bp from pter      End:
141,534,008 bp from pter
Size:
45,939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NFIP1_HUMAN, Q9BT67 (See protein sequence)
Recommended Name: NEDD4 family-interacting protein 1  
Size: 221 amino acids; 24899 Da
Subunit: Forms heterodimers with NDFIP2. Interacts with several E3 ubiquitin-protein ligases, including NEDD4,
NEDD4L and WWP2. Interacts with ITCH, U2SURP and WWP2 (By similarity). The interaction with NEDD4, NEDD4L and
ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion. Interacts with
SLC11A2/DMT1. Interacts with PTEN. May interact with phosphorylated EGFR
Secondary accessions: B2RDB8 D3DQF0 Q658T8 Q8N2E3 Q8N2F9
Alternative splicing: 2 isoforms:  Q9BT67-1   Q9BT67-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDFIP1: NX_Q9BT67

Explore proteomics data for NDFIP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its
    degradation1
  • Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC.
    Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP11
  • Ubiquitination2 at Lys63, Lys83
  • Modification sites at PhosphoSitePlus

  • See NDFIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_085048.1  
    ENSEMBL proteins: 
     ENSP00000253814  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019325 NEDD4/BSD2

    Graphical View of Domain Structure for InterPro Entry Q9BT67

    ProtoNet protein and cluster: Q9BT67

    UniProtKB/Swiss-Prot: NFIP1_HUMAN, Q9BT67
    Domain: The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for
    ubiquitination


    Find genes that share domains with NDFIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIP1_HUMAN, Q9BT67
    Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and
    consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents
    chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By
    similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to
    down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity.
    Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8
    signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through
    ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate
    Induction: Increased protein expression in neuronal cells in response to Co(2+) or Fe(2+) ions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI18776082
    GO:0050699WW domain binding IEA--
         
    Find genes that share ontologies with NDFIP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NDFIP1:
     Increased G2M DNA content  Increased number of mitotic ce 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ndfip1):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  respiratory system 

    Find genes that share phenotypes with NDFIP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NDFIP1

    miRNA
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    miRTarBase miRNAs that target NDFIP1:
    hsa-mir-15b-5p (MIRT046433), hsa-mir-221-3p (MIRT024174), hsa-mir-378a-3p (MIRT043897), hsa-mir-30a-5p (MIRT028563), hsa-mir-196a-5p (MIRT048220)

    Block miRNA regulation of human, mouse, rat NDFIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDFIP1 (see all 85):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-1258 hsa-miR-138-2* hsa-miR-371-5p hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidNDFIP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFIP1_HUMAN, Q9BT67: Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane (By similarity).
    Secreted. Note=Detected in exosomes and secreted via the exosomal pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    golgi apparatus2
    plasma membrane2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005576extracellular region IEA--
    GO:0005794Golgi apparatus ----
    GO:0005938cell cortex IEA--
    GO:0010008endosome membrane IEA--

    Find genes that share ontologies with NDFIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDFIP1
    Interactions:

        GeneGlobe Interaction Network for NDFIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDFIP1 (Q9BT673 ENSP000002538144) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    SLC11A2P492813, ENSP000002620524I2D: score=1 STRING: ENSP00000262052
    NEDD4LQ96PU53, ENSP000003831994I2D: score=1 STRING: ENSP00000383199
    NEDD4P469343, ENSP000003455304I2D: score=4 STRING: ENSP00000345530
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002761regulation of myeloid leukocyte differentiation IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006879cellular iron ion homeostasis IMP18776082
    GO:0007165signal transduction IMP12761501
    GO:0010629negative regulation of gene expression IMP18776082

    Find genes that share ontologies with NDFIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for NDFIP1 (NFIP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDFIP1 gene: 
    NM_030571.3  

    Unigene Cluster for NDFIP1:

    Nedd4 family interacting protein 1
    Hs.9788  [show with all ESTs]
    Unigene Representative Sequence: AK124884
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253814(uc003lmj.1 uc003lmi.4) ENST00000509436 ENST00000505614
    ENST00000503388
    miRNA
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    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-1258 hsa-miR-138-2* hsa-miR-371-5p hsa-miR-3162-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat NDFIP1
      QuantiFast Probe-based Assays in human, mouse, rat NDFIP1

    Additional mRNA sequence: 

    AB097010.1 AB097037.1 AK075495.1 AK075524.1 AK124884.1 AK315481.1 AL832993.1 AY192728.1 
    BC004317.1 

    21 DOTS entries:

    DT.449327  DT.100688994  DT.95085392  DT.99938336  DT.95085388  DT.100817720  DT.452679  DT.95085409 
    DT.100030769  DT.100817715  DT.100817721  DT.100817717  DT.120868298  DT.97815041  DT.100843484  DT.120868230 
    DT.120868232  DT.449325  DT.86840702  DT.91663951  DT.95229339 

    Selected AceView cDNA sequences (see all 782):

    AA890689 BG741788 AA628578 AI566161 BQ270216 AW167862 AI361356 F02527 
    BX411356 AI027067 BX375431 AA620561 BQ711755 BM662802 AB097037 AI207050 
    F04532 W32323 CR608893 AI570545 AA399423 AI091239 BM693839 N57112 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NDFIP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                                               -                     
    SP2:                    -                 -                                                   
    SP3:                                                                    -     -               
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NDFIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDFIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTCTCA
    NDFIP1 Expression
    About this image


    NDFIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NDFIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDFIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9788

    UniProtKB/Swiss-Prot: NFIP1_HUMAN, Q9BT67
    Tissue specificity: Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney,
    liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDFIP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndfip11 , 5 Nedd4 family interacting protein 11, 5 93.36(n)1
    97.16(a)1
      18 (20.32 cM)5
    651131  NM_022996.11  NP_075372.11 
     384189755 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    90(a)
    89(a)
    many → 1
    many → 1
    13(16565758-16577228)
    13(16647011-16655384)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    63(a)
    many → 1
    many → 1
    2(127008220-127031256)
    2(126990291-126991639)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853574.12   -- 82.05(n)    BX853574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17e112 wufc17e11 76.42(n)   324047  BC044423.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndfip1 Nedd4 family interacting protein 48.09(n)
    42.62(a)
      326197  NM_168743.3  NP_730291.1 


    ENSEMBL Gene Tree for NDFIP1 (if available)
    TreeFam Gene Tree for NDFIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDFIP1 gene
    NDFIP22  
    1 SIMAP similar gene for NDFIP1 using alignment to 1 protein entry:     NFIP1_HUMAN:
    NDFIP2

    Find genes that share paralogs with NDFIP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NDFIP1
    PGOHUM00000239364


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDFIP1 (see all 1005)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756334511,2
    --141486376(+) AGGCCA/GACAAA 1 -- us2k10--------
    rs2001471211,2
    C--141486397(+) TTTTTC/TTTTTT 1 -- us2k10--------
    rs750443511,2
    C,F--141486433(+) TGTTGC/ACCAGG 1 -- us2k13Minor allele frequency- A:0.13WA NA EA 358
    rs1852232371,2
    --141486444(+) TTGGTC/TTCGAA 1 -- us2k10--------
    rs117432071,2
    C,H--141486469(+) GCTCAC/TGTGAT 1 -- us2k1 tfbs30--------
    rs1140710221,2
    F--141486513(+) ACAGAT/CGTGAG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1900532421,2
    --141486811(+) CTCCCA/GGCATG 1 -- us2k10--------
    rs1424878101,2
    --141486854(+) ACAGAC/TATAGA 1 -- us2k10--------
    rs1932282311,2
    --141487065(+) GGAAAA/GGCAAT 1 -- us2k10--------
    rs360615081,2
    C,F,H--141487203(+) TAGCTA/GTACTG 1 -- us2k124Minor allele frequency- G:0.19NS EA NA WA CSA 2352

    HapMap Linkage Disequilibrium report for NDFIP1 (141488070 - 141534008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDFIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509994CNV Loss20534489
    nsv830509CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDFIP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612050    OMIM disorders: --

    1 disease for NDFIP1:    
    About MalaCards
    breast cancer


    Find genes that share disorders with NDFIP1           About GenesLikeMe

    Genetic Association Database (GAD): NDFIP1
    Human Genome Epidemiology (HuGE) Navigator: NDFIP1 (1 document)

    Export disorders for NDFIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDFIP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with NDFIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (PubMed id 11748237)1, 2, 3 Harvey K.F.... Kumar S. (J. Biol. Chem. 2002)
    2. Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. (PubMed id 19706893)1, 2, 9 Howitt J.... Tan S.S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. (PubMed id 18819914)1, 2, 9 Putz U....Tan S.S. (J. Biol. Chem. 2008)
    4. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2, 9 Mund T. and Pelham H.R. (EMBO Rep. 2009)
    5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    6. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. (PubMed id 20534535)1, 2 Mund T. and Pelham H.R. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. (PubMed id 18776082)1, 2 Foot N.J.... Kumar S. (Blood 2008)
    8. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80762 HGNC: 17592 AceView: NDFIP1 Ensembl:ENSG00000131507 euGenes: HUgn80762
    ECgene: NDFIP1 H-InvDB: NDFIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDFIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDFIP1 gene:
    Search GeneIP for patents involving NDFIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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