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Aliases for NDEL1 Gene

Aliases for NDEL1 Gene

  • NudE Neurodevelopment Protein 1-Like 1 2 3
  • NUDEL 3 4 6
  • Mitosin-Associated Protein 1 3 4
  • Protein Nudel 3 4
  • MITAP1 3 4
  • EOPA 3 4
  • NudE Nuclear Distribution Gene E Homolog (A. Nidulans)-Like 1 2
  • NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 2
  • NudE Nuclear Distribution Gene E Homolog-Like 1 3
  • NudE Nuclear Distribution E Homolog-Like 1 3
  • Nuclear Distribution Protein NudE-Like 1 3
  • Mitosin-Associated Protein MITAP1 3
  • Endooligopeptidase A 3
  • NDE1L1 3
  • NDE2 3

External Ids for NDEL1 Gene

Summaries for NDEL1 Gene

Entrez Gene Summary for NDEL1 Gene

  • This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDEL1 Gene

NDEL1 (NudE Neurodevelopment Protein 1-Like 1) is a Protein Coding gene. Diseases associated with NDEL1 include iridocyclitis. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding and alpha-tubulin binding. An important paralog of this gene is NDE1.

UniProtKB/Swiss-Prot for NDEL1 Gene

  • Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Gene Wiki entry for NDEL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDEL1 Gene

Genomics for NDEL1 Gene

Genomic Location for NDEL1 Gene

Start:
8,413,129 bp from pter
End:
8,490,411 bp from pter
Size:
77,283 bases
Orientation:
Plus strand

Genomic View for NDEL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDEL1 Gene

Regulatory Elements for NDEL1 Gene

Proteins for NDEL1 Gene

  • Protein details for NDEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM8-NDEL1_HUMAN
    Recommended name:
    Nuclear distribution protein nudE-like 1
    Protein Accession:
    Q9GZM8
    Secondary Accessions:
    • B3KP93
    • D3DTS0
    • J3QT32
    • Q86T80
    • Q8TAR7
    • Q9UH50

    Protein attributes for NDEL1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38375 Da
    Quaternary structure:
    • Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365.

    Three dimensional structures from OCA and Proteopedia for NDEL1 Gene

    Alternative splice isoforms for NDEL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDEL1 Gene

Proteomics data for NDEL1 Gene at MOPED

Post-translational modifications for NDEL1 Gene

  • Palmitoylation at Cys-273 reduces affinity for dynein.
  • Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDEL1 Gene

Domains for NDEL1 Gene

Protein Domains for NDEL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZM8

UniProtKB/Swiss-Prot:

NDEL1_HUMAN
Family:
  • Belongs to the nudE family.:
    • Q9GZM8
genes like me logo Genes that share domains with NDEL1: view

No data available for Gene Families for NDEL1 Gene

Function for NDEL1 Gene

Molecular function for NDEL1 Gene

UniProtKB/Swiss-Prot Function: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Gene Ontology (GO) - Molecular Function for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12812986
GO:0008017 microtubule binding IBA --
GO:0032403 protein complex binding --
GO:0043014 alpha-tubulin binding IEA --
GO:0048487 beta-tubulin binding IEA --
genes like me logo Genes that share ontologies with NDEL1: view
genes like me logo Genes that share phenotypes with NDEL1: view

Animal Models for NDEL1 Gene

MGI Knock Outs for NDEL1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NDEL1 Gene

Localization for NDEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDEL1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDEL1 Gene COMPARTMENTS Subcellular localization image for NDEL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17600710
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005635 nuclear envelope IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NDEL1: view

Pathways for NDEL1 Gene

genes like me logo Genes that share pathways with NDEL1: view

Gene Ontology (GO) - Biological Process for NDEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IBA --
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0001764 neuron migration IEA --
GO:0001833 inner cell mass cell proliferation IEA --
genes like me logo Genes that share ontologies with NDEL1: view

Transcripts for NDEL1 Gene

Unigene Clusters for NDEL1 Gene

NudE nuclear distribution E homolog (A. nidulans)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDEL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8: - - - -
SP9:
SP10: -

Relevant External Links for NDEL1 Gene

GeneLoc Exon Structure for
NDEL1
ECgene alternative splicing isoforms for
NDEL1

Expression for NDEL1 Gene

mRNA expression in normal human tissues for NDEL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDEL1 Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDEL1 Gene

SOURCE GeneReport for Unigene cluster for NDEL1 Gene Hs.372123

mRNA Expression by UniProt/SwissProt for NDEL1 Gene

Q9GZM8-NDEL1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with NDEL1: view

Orthologs for NDEL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDEL1 35
  • 99.89 (n)
  • 100 (a)
NDEL1 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDEL1 35
  • 95.27 (n)
  • 99.13 (a)
NDEL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDEL1 35
  • 93.62 (n)
  • 98.84 (a)
NDEL1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndel1 35
  • 91.3 (n)
  • 95.94 (a)
Ndel1 16
Ndel1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDEL1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndel1 35
  • 92.08 (n)
  • 95.94 (a)
chicken
(Gallus gallus)
Aves NDEL1 35
  • 82.8 (n)
  • 92.13 (a)
NDEL1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDEL1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndel1 35
  • 70.09 (n)
  • 79.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3827 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ndel1a 36
  • 72 (a)
OneToMany
ndel1b 35
  • 68.12 (n)
  • 77.26 (a)
ndel1b 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009914 35
  • 44.09 (n)
  • 39.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta nudE 35
  • 47.46 (n)
  • 42.75 (a)
nudE 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1886 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8970 36
  • 42 (a)
OneToMany
Species with no ortholog for NDEL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDEL1 Gene

ENSEMBL:
Gene Tree for NDEL1 (if available)
TreeFam:
Gene Tree for NDEL1 (if available)

Paralogs for NDEL1 Gene

Paralogs for NDEL1 Gene

Pseudogenes.org Pseudogenes for NDEL1 Gene

genes like me logo Genes that share paralogs with NDEL1: view

Variants for NDEL1 Gene

Sequence variations from dbSNP and Humsavar for NDEL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8852 -- 8,467,703(+) TCCTC(C/T)GTGCG utr-variant-3-prime
rs171997 -- 8,428,831(+) accac(A/G)cccgg intron-variant
rs174899 -- 8,428,908(+) gacct(C/T)gtgat intron-variant
rs185604 -- 8,442,810(-) tccgt(C/T)taaaa intron-variant, upstream-variant-2KB
rs190589 -- 8,428,962(+) gccac(C/T)gcgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDEL1 Gene

Variant ID Type Subtype PubMed ID
nsv509651 CNV Insertion 20534489
nsv112058 CNV Loss 16902084

Relevant External Links for NDEL1 Gene

HapMap Linkage Disequilibrium report
NDEL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDEL1 Gene

Disorders for NDEL1 Gene

(1) MalaCards Diseases for NDEL1 Gene

Search for NDEL1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for NDEL1 Gene

Relevant External Links for NDEL1

Genetic Association Database (GAD)
NDEL1
Human Genome Epidemiology (HuGE) Navigator
NDEL1
genes like me logo Genes that share disorders with NDEL1: view

No data available for UniProtKB/Swiss-Prot for NDEL1 Gene

Publications for NDEL1 Gene

  1. NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein. (PMID: 11163260) Niethammer M. … Tsai L.-H. (Neuron 2000) 2 3 4 23
  2. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. (PMID: 12556484) Yan X. … Zhu X. (Mol. Cell. Biol. 2003) 3 4 23
  3. Inhibition of NUDEL (nuclear distribution element-like)- oligopeptidase activity by disrupted-in-schizophrenia 1. (PMID: 15728732) Hayashi M.A.F. … de Camargo A.C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  4. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PMID: 16203747) Toyo-Oka K. … Hirotsune S. (Hum. Mol. Genet. 2005) 3 4 23
  5. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. (PMID: 17035248) Kamiya A. … Sawa A. (Hum. Mol. Genet. 2006) 3 4 23

Products for NDEL1 Gene

  • Addgene plasmids for NDEL1

Sources for NDEL1 Gene

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