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NDEL1 Gene

protein-coding   GIFtS: 59
GCID: GC17P008279

NudE Neurodevelopment Protein 1-Like 1

(Previous names: nudE nuclear distribution gene E homolog (A. nidulans)-like...)
  See NDEL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NudE Neurodevelopment Protein 1-Like 11 2     NDE1L12
NUDEL2 3 5     NDE22
Mitosin-Associated Protein 12 3     Endooligopeptidase A2
Protein Nudel2 3     Mitosin-Associated Protein MITAP12
EOPA2 3     Nuclear Distribution Protein NudE-Like 12
MITAP12 3     NudE Nuclear Distribution E Homolog-Like 12
NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 11     NudE Nuclear Distribution Gene E Homolog-Like 12
NudE Nuclear Distribution Gene E Homolog (A. Nidulans)-Like 11     

External Ids:    HGNC: 176201   Entrez Gene: 815652   Ensembl: ENSG000001665797   OMIM: 6075385   UniProtKB: Q9GZM83   

Export aliases for NDEL1 gene to outside databases

Previous GC identifers: GC17P008282 GC17P008539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDEL1 Gene:
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal
organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on
the long arm of chromosome X. (provided by RefSeq, Mar 2012)

GeneCards Summary for NDEL1 Gene:
NDEL1 (nudE neurodevelopment protein 1-like 1) is a protein-coding gene. Diseases associated with NDEL1 include iridocyclitis. GO annotations related to this gene include microtubule binding and alpha-tubulin binding. An important paralog of this gene is NDE1.

UniProtKB/Swiss-Prot: NDEL1_HUMAN, Q9GZM8
Function: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.
May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to
the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein
dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the
centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during
brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the
cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis
in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead
requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL

Gene Wiki entry for NDEL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDEL1 gene promoter:
         RFX1   p53   Olf-1   POU3F2 (N-Oct-5b)   Egr-2   Max   ARP-1   Hlf   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDEL1 promoter sequence
   Search Chromatin IP Primers for NDEL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDEL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

NDEL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDEL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008279:  view genomic region     (about GC identifiers)

Start:
8,316,449 bp from pter      End:
8,393,729 bp from pter
Size:
77,281 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDEL1_HUMAN, Q9GZM8 (See protein sequence)
Recommended Name: Nuclear distribution protein nudE-like 1  
Size: 345 amino acids; 38375 Da
Subunit: Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules
(By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1,
PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365
Developmental stage: Expression peaks in mitosis
Caution: Was originally (PubMed:15728732) thought to function as an oligopeptidase (NUDEL-oligopeptidase or
endooligopeptidase A) which could regulate peptide levels relevant to brain function
1 PDB 3D structure from and Proteopedia for NDEL1:
2V66 (3D)    
Secondary accessions: B3KP93 D3DTS0 J3QT32 Q86T80 Q8TAR7 Q9UH50
Alternative splicing: 3 isoforms:  Q9GZM8-1   Q9GZM8-2   Q9GZM8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDEL1: NX_Q9GZM8

Explore proteomics data for NDEL1 at MOPED

Post-translational modifications: 

  • Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes
    interaction with KATNA1 and YWHAE1
  • Palmitoylation at Cys-273 reduces affinity for dynein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDEL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020750.1  NP_110435.1  

    ENSEMBL proteins: 
     ENSP00000462052   ENSP00000464154   ENSP00000463430   ENSP00000333982   ENSP00000463492  
     ENSP00000369364   ENSP00000384963   ENSP00000462458   ENSP00000462759   ENSP00000463351  
     ENSP00000464441   ENSP00000464634   ENSP00000299734  
    Reactome Protein details: Q9GZM8

    NDEL1 Human Recombinant Protein Products:

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    Novus Biologicals NDEL1 Proteins
    Novus Biologicals NDEL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NDEL1

     
    Search eBioscience for Proteins for NDEL1 

    NDEL1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for NDEL1

    NDEL1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NDEL1
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    Search eBioscience for ELISAs for NDEL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006964 NUDE_C

    Graphical View of Domain Structure for InterPro Entry Q9GZM8

    ProtoNet protein and cluster: Q9GZM8

    UniProtKB/Swiss-Prot: NDEL1_HUMAN, Q9GZM8
    Similarity: Belongs to the nudE family


    Find genes that share domains with NDEL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDEL1_HUMAN, Q9GZM8
    Function: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.
    May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to
    the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein
    dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
    Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the
    centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during
    brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the
    cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis
    in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead
    requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12812986
    GO:0008017microtubule binding IEA--
    GO:0032403protein complex binding ----
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--
         
    Find genes that share ontologies with NDEL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NDEL1:
     Decreased DCP1a protein expres 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ndel1):
     cellular  embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with NDEL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ndel1tm1.1Shr for NDEL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDEL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDEL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDEL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDEL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NDEL1:
    hsa-mir-93-5p (MIRT027990), hsa-mir-125a-5p (MIRT045706), hsa-mir-19b-3p (MIRT031092), hsa-mir-30a-5p (MIRT028403), hsa-mir-103a-3p (MIRT027032), hsa-mir-130b-3p (MIRT020142)

    Block miRNA regulation of human, mouse, rat NDEL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDEL1 (see all 58):
    hsa-miR-596 hsa-miR-1197 hsa-miR-300 hsa-miR-106a hsa-miR-765 hsa-miR-16-1* hsa-miR-30d hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidNDEL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NDEL1
    Predesigned siRNA for gene silencing in human, mouse, rat NDEL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDEL1

    Clone
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    OriGene clones in human, mouse for NDEL1 (see all 11)
    OriGene ORF clones in mouse, rat for NDEL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDEL1 (NM_001025579)
    Sino Biological Human cDNA Clone for NDEL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDEL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDEL1
    Addgene plasmids for NDEL1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NDEL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDEL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDEL1_HUMAN, Q9GZM8: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the
    motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the
    microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region,
    including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle.
    Localizes to the kinetochore in a CENPF-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA17600710
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005635nuclear envelope IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NDEL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDEL1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Beta-Adrenergic Signaling
    CDK5 Pathway0.36
    5Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)


    Find genes that share SuperPaths with NDEL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NDEL1
        Reelin Pathway (Cajal-Retzius cells)
    CDK5 Pathway

    2 BioSystems Pathways for NDEL1
        Aurora A signaling
    Lissencephaly gene (LIS1) in neuronal migration and development


    3 Reactome Pathways for NDEL1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDEL1
    Interactions:

        GeneGlobe Interaction Network for NDEL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDEL1 (Q9GZM81, 2, 3 ENSP000003339824) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-928842,EBI-529989 I2D: score=5 STRING: ENSP00000355596
    MBIPQ9NS732, 3, ENSP000003244444MINT-66794 I2D: score=5 STRING: ENSP00000324444
    CENPFP494541, 3, ENSP000003559224EBI-928842,EBI-968343 I2D: score=2 STRING: ENSP00000355922
    DYNC1I1O145762, 3, ENSP000003201304MINT-7689927 I2D: score=2 STRING: ENSP00000320130
    C7orf55-LUC7L2Q9Y3833, ENSP000003470054I2D: score=2 STRING: ENSP00000347005
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration IEA--
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0007059chromosome segregation IMP17600710

    Find genes that share ontologies with NDEL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDEL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDEL1 gene (2 alternative transcripts): 
    NM_001025579.2  NM_030808.4  

    Unigene Cluster for NDEL1:

    NudE nuclear distribution E homolog (A. nidulans)-like 1
    Hs.372123  [show with all ESTs]
    Unigene Representative Sequence: AL832648
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000582812 ENST00000579150 ENST00000580237 ENST00000582665 ENST00000579880
    ENST00000334527(uc002gli.3 uc002glj.3) ENST00000585098 ENST00000380025
    ENST00000402554 ENST00000584866 ENST00000582490 ENST00000580738 ENST00000583066
    ENST00000580012 ENST00000581189 ENST00000582277 ENST00000581679 ENST00000583683

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDEL1 (see all 58):
    hsa-miR-596 hsa-miR-1197 hsa-miR-300 hsa-miR-106a hsa-miR-765 hsa-miR-16-1* hsa-miR-30d hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidNDEL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDEL1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDEL1 (NM_001025579)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDEL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDEL1
    Addgene plasmids for NDEL1 
    Primer
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    OriGene qPCR primer pairs and template standards for NDEL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDEL1
      QuantiTect SYBR Green Assays in human, mouse, rat NDEL1
      QuantiFast Probe-based Assays in human, mouse, rat NDEL1

    Additional mRNA sequence: 

    AF038203.1 AF182078.1 AF217798.3 AK056014.1 AK123802.1 AL832648.1 AY004871.1 BC026101.2 
    BC131748.1 

    Selected DOTS entries (see all 27):

    DT.95073811  DT.452177  DT.120920930  DT.100820731  DT.120920929  DT.120920967  DT.40129094  DT.120920979 
    DT.120920884  DT.97759886  DT.452176  DT.95316161  DT.99976051  DT.100820730  DT.120920861  DT.435880 
    DT.100028764  DT.100820728  DT.304448  DT.95195155  DT.120920822  DT.120920826  DT.120920865  DT.120920891 

    Selected AceView cDNA sequences (see all 249):

    CR607599 BM673074 AI818483 AA535123 AW298400 BM309857 CF132478 H00177 
    AI962663 H88961 CB126006 BM694395 AA442918 AW296092 AI049776 AA885372 
    BI522804 AI126751 AA906857 BE041590 F10899 CK905226 BM720002 AI033392 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDEL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                          -     -     -           -                       -                                                     -     -         
    SP2:                                                  -                       -                                                                     
    SP3:                                                                                                                                -               
    SP4:                          -     -     -                                                                                                         
    SP5:                          -                       -                                                                                             


    ECgene alternative splicing isoforms for NDEL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NDEL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTACAAA
    NDEL1 Expression
    About this image


    NDEL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Neural Tube (Nervous System)
             Metencephalon
    NDEL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDEL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372123

    UniProtKB/Swiss-Prot: NDEL1_HUMAN, Q9GZM8
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDEL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndel11 , 5 nuclear distribution gene E-like homolog 1 (A. nidulans)1, 5 91.3(n)1
    95.94(a)1
      11 (42.09 cM)5
    834311  NM_023668.21  NP_076157.21 
     688214345 
    chicken
    (Gallus gallus)
    Aves NDEL11 nudE nuclear distribution E homolog (A. nidulans)-like more 82.8(n)
    92.13(a)
      417317  NM_001030696.1  NP_001025867.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDEL16
    nudE neurodevelopment protein 1-like 1
    80(a)
    1 ↔ 1
    2(104900988-104939017)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndel11 nudE neurodevelopment protein 1-like 1 70.09(n)
    79.18(a)
      548955  XM_004919601.1  XP_004919658.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055587.12   -- 76.14(n)   394244  BC055587.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nudE1 nudE 47.46(n)
    42.75(a)
      39169  NM_001104098.2  NP_001097568.1 


    ENSEMBL Gene Tree for NDEL1 (if available)
    TreeFam Gene Tree for NDEL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDEL1 gene
    NDE12  
    1 SIMAP similar gene for NDEL1 using alignment to 11 protein entries:     NDEL1_HUMAN (see all proteins):
    NDE1

    Find genes that share paralogs with NDEL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NDEL1
    PGOHUM00000263341 PGOHUM00000263342


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDEL1 (see all 666)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759881611,2
    F--8237404(-) GTGTTG/AGCCAG 2 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1404684541,2
    --8325972(+) ATTCAA/TAATAT 2 -- us2k10--------
    rs1504025231,2
    C--8326018(+) CCACAA/GACCCC 2 -- us2k10--------
    rs1476560351,2
    C--8326138(+) TCACTC/TTGTTT 2 -- us2k10--------
    rs759658001,2
    C,F--8326175(+) ATTTTT/CGTGTT 2 -- us2k11Minor allele frequency- C:0.04NA 120
    rs802246231,2
    C,F--8326209(+) AAGCAC/TTGAAA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1878072431,2
    --8326278(+) GTGGGA/GGGCTG 2 -- us2k10--------
    rs1422865431,2
    --8326411(+) GGGTTC/TGAGCG 2 -- us2k10--------
    rs1923263821,2
    --8326437(+) CCTCCA/GGAGTA 2 -- us2k10--------
    rs110787501,2
    C,A,H--8326536(+) TCGAAC/GTCCTG 2 -- us2k17Minor allele frequency- G:0.07NA WA CSA 15

    HapMap Linkage Disequilibrium report for NDEL1 (8316449 - 8393729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDEL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509651CNV Insertion20534489
    nsv112058CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDEL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NDEL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607538    OMIM disorders: --

    1 disease for NDEL1:    
    About MalaCards
    iridocyclitis

    3 diseases from the University of Copenhagen DISEASES database for NDEL1:
    Lissencephaly     Iridocyclitis     Schizophrenia

    Find genes that share disorders with NDEL1           About GenesLikeMe

    Genetic Association Database (GAD): NDEL1
    Human Genome Epidemiology (HuGE) Navigator: NDEL1 (4 documents)

    Export disorders for NDEL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDEL1 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with NDEL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein. (PubMed id 11163260)1, 2, 3, 9 Niethammer M.... Tsai L.-H. (Neuron 2000)
    2. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PubMed id 16203747)1, 2, 9 Toyo-Oka K.... Hirotsune S. (Hum. Mol. Genet. 2005)
    3. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. (PubMed id 12556484)1, 2, 9 Yan X.... Zhu X. (Mol. Cell. Biol. 2003)
    4. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. (PubMed id 17035248)1, 2, 9 Kamiya A.... Sawa A. (Hum. Mol. Genet. 2006)
    5. Inhibition of NUDEL (nuclear distribution element-like)- oligopeptidase activity by disrupted-in-schizophrenia 1. (PubMed id 15728732)1, 2, 9 Hayashi M.A.F.... de Camargo A.C.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. (PubMed id 19927128)1, 2 Shmueli A.... Reiner O. (EMBO J. 2010)
    7. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PubMed id 19251251)1, 4 Tomppo L....Peltonen L. (Biol. Psychiatry 2009)
    8. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. (PubMed id 19632097)1, 4 Rastogi A....Wong A.H. (Schizophr. Res. 2009)
    9. Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. (PubMed id 18469341)1, 4 Burdick K.E....Malhotra A.K. (Hum. Mol. Genet. 2008)
    10. Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. (PubMed id 17600710)1, 2 Vergnolle M.A.S. and Taylor S.S. (Curr. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81565 HGNC: 17620 AceView: NDEL1 Ensembl:ENSG00000166579 euGenes: HUgn81565
    ECgene: NDEL1 H-InvDB: NDEL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDEL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDEL1 gene:
    Search GeneIP for patents involving NDEL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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