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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NDE1 Gene

protein-coding GIFtS: 55
GCID: GC16P015740

nudE nuclear distribution E homolog 1 (A. nidulans)

(Previous name: nudE nuclear distribution gene E homolog 1 (A. nidulans)...)

Explore 13 diseases affiliated with
NDE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NudE Nuclear Distribution E Homolog 1 (A. Nidulans)¹ ²		NUDE1²
NUDE¹ ² ³ ⁵		LIS1-Interacting Protein NUDE1, Rat Homolog²
FLJ20101¹		Nuclear Distribution Protein NudE Homolog 1²
NudE Nuclear Distribution Gene E Homolog 1 (A. Nidulans)¹		NudE Nuclear Distribution Gene E Homolog 1²
HOM-TES-87²		NudE³
LIS4²

External Ids:	HGNC: 17619¹	Entrez Gene: 54820²	Ensembl: ENSG00000072864⁷	OMIM: 609449⁵	UniProtKB: Q9NXR1³

Export aliases for NDE1 gene to outside databases

Previous GC identifers: GC16P015664 GC16P015710 GC16P015651 GC16P015739 GC16P015130

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDE1:

This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at

the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein

function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations

in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and

severe mental retardation. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar

2012)

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1

Function: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the

development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the

mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain.

Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal

progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a

post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an

overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the

cortex

Gene Wiki entry for NDE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NDE1 gene promoter:
ISGF-3 IRF-2 Lmo2 NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDE1 promoter sequence

Search SABiosciences Chromatin IP Primers for NDE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11

NDE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDE1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P015740: view genomic region (about GC identifiers)

Start:	15,737,124 bp from pter	End:	15,820,210 bp from pter
Size:	83,087 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1 (See protein sequence)

Recommended Name: Nuclear distribution protein nudE homolog 1

Size: 346 amino acids; 38808 Da

Subunit: Self-associates. Interacts with CEP110, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF,

dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere,

kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase

centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of

microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the

cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis

Secondary accessions: Q49AQ2

Alternative splicing: 2 isoforms: Q9NXR1-1 Q9NXR1-2

Explore the universe of human proteins at neXtProt for NDE1: NX_Q9NXR1

Post-translational modifications:

Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M

transition (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NXR1

NDE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137451.1 NP_060138.1

ENSEMBL proteins:

ENSP00000379643 ENSP00000379642 ENSP00000459889 ENSP00000460436 ENSP00000460996

ENSP00000461729 ENSP00000459875 ENSP00000459863 ENSP00000461748 ENSP00000459918

ENSP00000345892 ENSP00000379641

Reactome Protein details: Q9NXR1
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	ProSpec Recombinant Protein for NDE1
	Uscn Proteins for NDE1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	IDA	17600710
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0005813	centrosome	IDA	--
GO:0005815	microtubule organizing center	--	--
GO:0005819	spindle	--	--

NDE1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NDE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NDE1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006964 NUDE_C

Graphical View of Domain Structure for InterPro Entry Q9NXR1

ProtoNet protein and cluster: Q9NXR1

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1

Similarity: Belongs to the nudE family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1

Function: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the

development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the

mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain.

Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal

progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a

post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an

overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the

cortex

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDE1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16682949
GO:0008017	microtubule binding	ISS	--
GO:0019904	protein domain specific binding	IEA	--
GO:0042802	identical protein binding	IEA	--

NDE1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for NDE1:

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Nde1^tm1Caw for NDE1
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nde1):

cellular

nervous system

NDE1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Recruitment of mitotic centrosome proteins and complexes

Centrosome maturation	1.00	Mitotic G2-G2/M phases	0.81
Recruitment of mitotic centrosome proteins and complexes	1.00	Loss of proteins required for interphase microtubule organizationÂ from the centrosome	0.78
G2/M Transition	0.83	Loss of Nlp from mitotic centrosomes	0.78

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

5/16 Reactome Pathways for NDE1 (see all 16)

	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Cell Cycle
	M Phase
	Recruitment of mitotic centrosome proteins and complexes

NDE1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NDE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for NDE1 (Q9NXR1^{1, 3} ENSP00000345892⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF365	Q70YC5¹^,³, ENSP00000387091⁴	EBI-941227,EBI-941182 I2D: score=2 STRING: ENSP00000387091
PAFAH1B1	P43034³, ENSP00000380378⁴	I2D: score=3 STRING: ENSP00000380378
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=1 STRING: ENSP00000215832
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=1 STRING: ENSP00000306330
CENPF	P49454³, ENSP00000355922⁴	I2D: score=1 STRING: ENSP00000355922

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000132	establishment of mitotic spindle orientation	IMP	19468067
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

NDE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NDE1
Search CenterWatch for drugs/clinical trials and news about NDE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NDE1 gene (2 alternative transcripts):

NM_001143979.1 NM_017668.2

Unigene Cluster for NDE1:

NudE nuclear distribution E homolog 1 (A. nidulans)

Hs.655378 [show with all ESTs]

Unigene Representative Sequence: BC033900

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396355(uc010uzy.2) ENST00000396354(uc002dds.3) ENST00000570727

ENST00000572756 ENST00000573203 ENST00000574163 ENST00000577101(uc002ddu.1)

ENST00000574109 ENST00000573694 ENST00000576502 ENST00000572967 ENST00000572503

ENST00000571896(uc002ddz.1) ENST00000342673 ENST00000396353(uc002ddt.1)

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Additional cDNA sequence:

AK000108.1 AK025815.1 AK091186.1 AK092997.1 AK123247.1 BC001421.2 BC033900.1

22 DOTS entries:

DT.449883 DT.92462101 DT.91845437 DT.92462075 DT.85105239 DT.95109215 DT.97759905 DT.91790325

DT.112103 DT.92462084 DT.92043408 DT.92462080 DT.92462081 DT.100747038 DT.40210065 DT.100686904

DT.407139 DT.91688377 DT.100886298 DT.101969271 DT.91696392 DT.92338250

24/209 AceView cDNA sequences (see all 209):

BQ933125 F25843 AI239643 AL520690 BF507369 BQ773758 BM800369 BM689509

BM542618 AI369244 BE303035 BX282472 AA479273 BM713068 BM999878 BG760232

BQ059706 BM811181 AI669922 AL710923 BM556954 BQ216415 BX415441 CB240572

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NDE1 (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11
SP1:							-						-
SP2:							-						-												-		-
SP3:													-												-		-		-		-		-
SP4:																									-
SP5:																									-		-

ECgene alternative splicing isoforms for NDE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NDE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NDE1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NDE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDE1

SOURCE GeneReport for Unigene cluster: Hs.655378

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1

Tissue specificity: Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and

cerebellum

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NDE1 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nde1^{1 , 5}	nuclear distribution gene E homolog 1 (A nidulans)^{1, 5}	84.5(n)¹ 91.4(a)¹		16 (9.70 cM)⁵ 67203¹ NM_023317.2¹ NP_075806.2¹ 14163275⁵
chicken (Gallus gallus)	Aves	NDE1¹	nudE nuclear distribution gene E homolog 1 (A. nidulans)	72.65(n) 80.45(a)		416597 NM_001006169.1 NP_001006169.1
lizard (Anolis carolinensis)	Reptilia	NDE1⁶	--	80(a)	1 ↔ 1	AAWZ02039644(3094-7681)
African clawed frog (Xenopus laevis)	Amphibia	LOC398067²	mitotic phosphoprotein 43	74.98(n)		U95097.1
zebrafish (Danio rerio)	Actinopterygii	nde1¹	nudE nuclear distribution gene E homolog 1 (A. nidulans)	61.78(n) 63.52(a)		566146 NM_001030203.1 NP_001025374.1
fruit fly (Drosophila melanogaster)	Insecta	nudE⁶	nudE	26(a)	1 → many	3L(9892341-9896065)
worm (Caenorhabditis elegans)	Secernentea	nud-2⁶	Aspergillus NUclear Division related family member...	20(a)	1 → many	I(7857818-7859412)

ENSEMBL Gene Tree for NDE1 (if available)
TreeFam Gene Tree for NDE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NDE1 gene

NDEL1²

1 SIMAP similar gene for NDE1 using alignment to 10 protein entries: NDE1_HUMAN (see all proteins):

NDEL1

NDE1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NDE1
PGOHUM00000248363 PGOHUM00000244831

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79302413^1,2		--	15134957(+)	`GGAAGG/ACAAGA`	1	--	int¹		1		NA	120
rs28633547^1,2	C,	--	15136880(+)	`AGTTCA/GAATTT`	2	--	int¹ us2k¹		2		WA	120
rs13333147^1,2	C	--	15136955(+)	`GTTTGT/CCTGTT`	2	--	us2k¹ int¹		1		NA	2
rs79255148^1,2	F,	--	15137397(+)	`ATAATG/AATGCT`	2	--	us2k¹ int¹		1		EA	120
rs8054732^1,2	C,A,	--	15138403(+)	`CACCCC/GCTTCT`	2	--	int¹		0	--	--	--	--
rs8045619^1,2	C,F,A,H	--	15139061(+)	`tttttG/Tttttt`	2	--	int¹		2		NA	4
rs75661433^1,2	F	--	15139077(+)	`TTTTGT/GTTTTG`	2	--	int¹		1		NA	6
rs8061771^1,2	C,	--	15139293(+)	`cctgaA/Cctcgt`	2	--	int¹		0	--	--	--	--
rs59026599^1,2	C,	--	15140532(+)	`CCTTCC/TGCCTC`	2	--	int¹		2		WA	120
rs77533098^1,2	F,	--	15141197(+)	`GCAGTG/ACTGGG`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for NDE1 (15737124 - 15820210 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NDE1
2 CNVs: 30745 2203
Human Gene Mutation Database (HGMD): NDE1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDE1

DNA2.0 Custom Variant and Variant Library Synthesis for NDE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NDE1 for disorders About GeneDecksing

OMIM gene information: 609449 OMIM disorders: --

UniProtKB/Swiss-Prot: NDE1_HUMAN, Q9NXR1

Defects in NDE1 are the cause of lissencephaly type 4 (LIS4) [MIM:614019]. A neurodevelopmental disorder

characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation

13 diseases for NDE1: About MalaCards

lissencephaly miller-dieker lissencephaly microcephaly lissencephaly 4

rhinosporidiosis acute myeloid leukemia neuronitis myeloid leukemia

convulsions paralysis leukemia cerebritis

schizophrenia

2 diseases from the University of Copenhagen DISEASES database for NDE1:

Lissencephaly Schizophrenia

Human Genome Epidemiology (HuGE) Navigator: NDE1 (6 documents)

Export disorders for NDE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NDE1 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with NDE1)

Utopia: connect your pdf to the dynamic
world of online information

Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. (PubMed id 12556484)^{1, 2, 9} Yan X.... Zhu X. (2003)
The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. (PubMed id 21529752)^{1, 2} Bakircioglu M.... Woods C.G. (2011)
Human mutations in NDE1 cause extreme microcephaly with lissencephaly. (PubMed id 21529751)^{1, 2} Alkuraya F.S.... Walsh C.A. (2011)
Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. (PubMed id 17600710)^{1, 2} Vergnolle M.A.S. and Taylor S.S. (2007)
Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. (PubMed id 16682949)^{1, 2} Hirohashi Y....Greene M.I. (2006)
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. (PubMed id 16291865)^{1, 2} Guo J.... Zhu X. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal movement. (PubMed id 12427674)^{1, 3} Meyer G....Gleeson J.G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54820	HGNC: 17619	AceView: NDE1	Ensembl:ENSG00000072864	euGenes: HUgn54820
ECgene: NDE1	H-InvDB: NDE1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NDE1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NDE1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NDE1 gene:
Search GeneIP for patents involving NDE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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nudE nuclear distribution E homolog 1 (A. nidulans)

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nudE nuclear distribution E homolog 1 (A. nidulans)

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