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Aliases for NDE1 Gene

Aliases for NDE1 Gene

  • NudE Neurodevelopment Protein 1 2 3
  • NUDE 3 4 6
  • LIS4 3 6
  • MHAC 3 6
  • NudE Nuclear Distribution Gene E Homolog 1 (A. Nidulans) 2
  • NudE Nuclear Distribution E Homolog 1 (A. Nidulans) 2
  • LIS1-Interacting Protein NUDE1, Rat Homolog 3
  • Nuclear Distribution Protein NudE Homolog 1 3
  • NudE Nuclear Distribution Gene E Homolog 1 3
  • NudE Nuclear Distribution E Homolog 1 3
  • HOM-TES-87 3
  • NUDE1 3
  • NDE 3

External Ids for NDE1 Gene

Previous GeneCards Identifiers for NDE1 Gene

  • GC16P015664
  • GC16P015710
  • GC16P015651
  • GC16P015739
  • GC16P015130
  • GC16P015740
  • GC16P015743
  • GC16P015745

Summaries for NDE1 Gene

Entrez Gene Summary for NDE1 Gene

  • This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDE1 Gene

NDE1 (NudE Neurodevelopment Protein 1) is a Protein Coding gene. Diseases associated with NDE1 include lissencephaly 4 and hydranencephaly. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is NDEL1.

UniProtKB/Swiss-Prot for NDE1 Gene

  • Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Gene Wiki entry for NDE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDE1 Gene

Genomics for NDE1 Gene

Regulatory Elements for NDE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDE1 Gene

Start:
15,643,267 bp from pter
End:
15,726,353 bp from pter
Size:
83,087 bases
Orientation:
Plus strand

Genomic View for NDE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDE1 Gene

Proteins for NDE1 Gene

  • Protein details for NDE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR1-NDE1_HUMAN
    Recommended name:
    Nuclear distribution protein nudE homolog 1
    Protein Accession:
    Q9NXR1
    Secondary Accessions:
    • Q49AQ2

    Protein attributes for NDE1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38808 Da
    Quaternary structure:
    • Self-associates. Interacts with CNTRL, LIS1, dynein, SLMAP and TCP1 (By similarity). Interacts with CENPF, dynactin, tubulin gamma, PAFAH1B1, PCM1 and PCNT. Interacts with ZNF365.

    Alternative splice isoforms for NDE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDE1 Gene

Proteomics data for NDE1 Gene at MOPED

Post-translational modifications for NDE1 Gene

  • Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDE1 Gene

Domains for NDE1 Gene

Protein Domains for NDE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXR1

UniProtKB/Swiss-Prot:

NDE1_HUMAN :
  • Q9NXR1
Family:
  • Belongs to the nudE family.
genes like me logo Genes that share domains with NDE1: view

No data available for Gene Families for NDE1 Gene

Function for NDE1 Gene

Molecular function for NDE1 Gene

UniProtKB/Swiss-Prot Function: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Gene Ontology (GO) - Molecular Function for NDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16682949
GO:0008017 microtubule binding ISS --
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with NDE1: view
genes like me logo Genes that share phenotypes with NDE1: view

Animal Models for NDE1 Gene

MGI Knock Outs for NDE1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NDE1 Gene

Localization for NDE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDE1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDE1 Gene COMPARTMENTS Subcellular localization image for NDE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17600710
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center --
GO:0005819 spindle --
genes like me logo Genes that share ontologies with NDE1: view

Pathways for NDE1 Gene

genes like me logo Genes that share pathways with NDE1: view

Gene Ontology (GO) - Biological Process for NDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0001764 neuron migration IEA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with NDE1: view

Transcripts for NDE1 Gene

Unigene Clusters for NDE1 Gene

NudE nuclear distribution E homolog 1 (A. nidulans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDE1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9:

Relevant External Links for NDE1 Gene

GeneLoc Exon Structure for
NDE1
ECgene alternative splicing isoforms for
NDE1

Expression for NDE1 Gene

mRNA expression in normal human tissues for NDE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDE1 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDE1 Gene

SOURCE GeneReport for Unigene cluster for NDE1 Gene Hs.655378

mRNA Expression by UniProt/SwissProt for NDE1 Gene

Q9NXR1-NDE1_HUMAN
Tissue specificity: Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.
genes like me logo Genes that share expressions with NDE1: view

In Situ Assay Products

Orthologs for NDE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDE1 35
  • 93.89 (n)
  • 92.36 (a)
NDE1 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDE1 35
  • 84.58 (n)
  • 88.66 (a)
NDE1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDE1 35
  • 89.95 (n)
  • 96.72 (a)
NDE1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nde1 35
  • 84.5 (n)
  • 91.4 (a)
Nde1 16
Nde1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDE1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDE1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nde1 35
  • 82.7 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves NDE1 35
  • 72.65 (n)
  • 80.45 (a)
NDE1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDE1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398067 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nde1 35
  • 66.77 (n)
  • 73.55 (a)
Str.8167 35
zebrafish
(Danio rerio)
Actinopterygii nde1 35
  • 62.84 (n)
  • 65.25 (a)
nde1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nudE 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8970 36
  • 41 (a)
OneToMany
Species with no ortholog for NDE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDE1 Gene

ENSEMBL:
Gene Tree for NDE1 (if available)
TreeFam:
Gene Tree for NDE1 (if available)

Paralogs for NDE1 Gene

Paralogs for NDE1 Gene

Selected SIMAP similar genes for NDE1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for NDE1 Gene

genes like me logo Genes that share paralogs with NDE1: view

Variants for NDE1 Gene

Sequence variations from dbSNP and Humsavar for NDE1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8529 -- 15,701,615(-) ACACC(A/G)TGGTG intron-variant
rs730140 -- 15,690,357(+) ctttt(C/T)ttttt intron-variant
rs760025 -- 15,691,892(-) GCACT(A/T)TGGGA intron-variant
rs1001319 -- 15,694,980(-) TTGCC(C/T)GGGCT intron-variant
rs1076550 -- 15,697,280(-) ggatc(A/G)cttga intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NDE1 Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
dgv2610n71 CNV Gain 21882294
nsv457428 CNV Gain 19166990
nsv469626 CNV Loss 16826518
nsv827569 CNV Loss 20364138
nsv9361 CNV Gain 18304495

Relevant External Links for NDE1 Gene

HapMap Linkage Disequilibrium report
NDE1
Human Gene Mutation Database (HGMD)
NDE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDE1 Gene

Disorders for NDE1 Gene

(2) OMIM Diseases for NDE1 Gene (609449)

UniProtKB/Swiss-Prot

NDE1_HUMAN
  • Lissencephaly 4 (LIS4) [MIM:614019]: A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation. {ECO:0000269 PubMed:21529751, ECO:0000269 PubMed:21529752}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Microhydranencephaly (MHAC) [MIM:605013]: A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. {ECO:0000269 PubMed:22526350}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for NDE1 Gene

Relevant External Links for NDE1

Genetic Association Database (GAD)
NDE1
Human Genome Epidemiology (HuGE) Navigator
NDE1
genes like me logo Genes that share disorders with NDE1: view

Publications for NDE1 Gene

  1. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. (PMID: 12556484) Yan X. … Zhu X. (Mol. Cell. Biol. 2003) 3 4 23
  2. DISC1, PDE4B, and NDE1 at the centrosome and synapse. (PMID: 18983980) Bradshaw N.J. … Millar J.K. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal movement. (PMID: 12427674) Meyer G. … Gleeson J.G. (Cereb. Cortex 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. (PMID: 10931877) Efimov V.P. … Morris N.R. (J. Cell Biol. 2000) 3 23

Products for NDE1 Gene

Sources for NDE1 Gene

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