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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NDC80 Gene

protein-coding GIFtS: 60
GCID: GC18P002571

NDC80 kinetochore complex component

(Previous names: highly expressed in cancer, rich in leucine heptad repeats...)
(Previous symbol: KNTC2)

Explore 9 diseases affiliated with
NDC80 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NDC80 Kinetochore Complex Component¹ ²		Kinetochore-Associated Protein 2² ³
HEC¹ ² ³		Retinoblastoma-Associated Protein HEC² ³
HEC1¹ ² ³		HsHec1² ³
KNTC2¹ ² ³		Highly Expressed In Cancer, Rich In Leucine Heptad Repeats (Yeast)¹
TID3¹ ²		NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae)¹
HsNDC80¹		Highly Expressed In Cancer, Rich In Leucine Heptad Repeats²
Kinetochore Associated 2¹ ²		Kinetochore Protein NDC80 Homolog²
Highly Expressed In Cancer Protein² ³		NDC80 Homolog, Kinetochore Complex Component²
Kinetochore Protein Hec1² ³		NDC80 Kinetochore Complex Component Homolog²

External Ids:	HGNC: 16909¹	Entrez Gene: 10403²	Ensembl: ENSG00000080986⁷	OMIM: 607272⁵	UniProtKB: O14777³

Export aliases for NDC80 gene to outside databases

Previous GC identifers: GC18P002562 GC18P002532

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDC80:

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal

microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex.

This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper

chromosome segregation. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NDC80_HUMAN, O14777

Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome

segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable

microtubule binding sites in the outer plate of the kinetochore

Gene Wiki entry for NDC80

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NDC80 gene promoter:
STAT5B GR CREB Nkx3-1 v4 Pax-5 ATF-2 deltaCREB Nkx3-1 v3 GR-alpha IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDC80 promoter sequence

Search SABiosciences Chromatin IP Primers for NDC80

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDC80

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.31

NDC80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDC80 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P002571: view genomic region (about GC identifiers)

Start:	2,571,510 bp from pter	End:	2,616,634 bp from pter
Size:	45,125 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDC80_HUMAN, O14777 (See protein sequence)

Recommended Name: Kinetochore protein NDC80 homolog

Size: 642 amino acids; 73913 Da

Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is

formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel

interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by

interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal

regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like

structure with globular domains at either end. Interacts with isoform 1 of NEK2 and ZWINT specifically during mitosis.

Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase

and mitosis

Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase

to anaphase. Localizes specifically to the outer plate of the kinetochore

Developmental stage: Expression peaks in mitosis

3 PDB 3D structures from and Proteopedia for NDC80:

2IGP (3D)

2VE7 (3D)

3IZ0 (3D)

Secondary accessions: Q6PJX2

Explore the universe of human proteins at neXtProt for NDC80: NX_O14777

Post-translational modifications:

Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be

phosphorylated by AURKA and AURKB¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14777

NDC80 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006092.1

ENSEMBL proteins:

ENSP00000261597 ENSP00000461227 ENSP00000458236

Reactome Protein details: O14777
Human Recombinant Protein Products:

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	Uscn Proteins for NDC80

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	TAS	9315664
GO:0000776	kinetochore	IDA	19468067
GO:0000777	condensed chromosome kinetochore	IDA	14699129
GO:0000942	condensed nuclear chromosome outer kinetochore	IDA	18195732
GO:0005634	nucleus	TAS	9315664

NDC80 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NDC80 for domains About GeneDecksing

1 InterPro domain/family:

IPR005550 Kinetochore_Ndc80

Graphical View of Domain Structure for InterPro Entry O14777

ProtoNet protein and cluster: O14777

UniProtKB/Swiss-Prot: NDC80_HUMAN, O14777

Similarity: Belongs to the NDC80/HEC1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NDC80_HUMAN, O14777

Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome

segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable

microtubule binding sites in the outer plate of the kinetochore

miRNA Products:		OriGene 3'-UTR Clone: NDC80 Browse MicroRNA Expression Plasmids
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDC80 (see all 7) OriGene shRNA RFP: NDC80 OriGene siRNA: NDC80
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDC80

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

NDC80 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for NDC80:

Cell cycle / mitosis defect	Cell division defect	Decreased cell number, increas	Decreased viability of wild-ty
Increased Salmonella enterica	Increased gamma-H2AX phosphory	Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Aurora B signaling

Aurora B signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NDC80

Cell cycle Spindle assembly and chromosome separation

1 GeneGo (Thomson Reuters) Pathway for NDC80

Cell cycle Spindle assembly and chromosome separation

2 BioSystems Pathways for NDC80

	PLK1 signaling events
	Aurora B signaling

5/10 Reactome Pathways for NDC80 (see all 10)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase
	Cell Cycle

NDC80 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NDC80

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/822 Interacting proteins for NDC80 (O14777^{1, 2, 3} ENSP00000261597⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 822)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BUB1	O43683²^,³, ENSP00000302530⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000302530
PLK1	P53350²^,³, ENSP00000300093⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000300093
BLOC1S6	Q9UL45²^,³, ENSP00000220531⁴	MINT-66567 I2D: score=5 STRING: ENSP00000220531
CALCOCO1	Q9P1Z2²^,³, ENSP00000262059⁴	MINT-68257 I2D: score=5 STRING: ENSP00000262059
CCDC53	Q9Y3C0²^,³, ENSP00000240079⁴	MINT-66964 I2D: score=5 STRING: ENSP00000240079

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000070	mitotic sister chromatid segregation	TAS	9315664
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000132	establishment of mitotic spindle orientation	IMP	19468067
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

NDC80 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NDC80
Search CenterWatch for drugs/clinical trials and news about NDC80

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NDC80 gene:

NM_006101.2

Unigene Cluster for NDC80:

NDC80 kinetochore complex component homolog (S. cerevisiae)

Hs.414407 [show with all ESTs]

Unigene Representative Sequence: NM_006101

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261597(uc002kli.3) ENST00000575515 ENST00000576274 ENST00000574567

ENST00000574096

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDC80

Additional cDNA sequence:

AF017790.1 AK289396.1 AK313184.1 BC005239.1 BC010171.2 BC035617.1

7 DOTS entries:

DT.413766 DT.91875217 DT.75101903 DT.91766976 DT.100765539 DT.121096331 DT.92062162

24/120 AceView cDNA sequences (see all 120):

BI087094 BU507911 BQ776118 BQ425406 BC005239 BF447144 AA639709 BC035617

AA857356 CR609890 AI866885 BU633554 BX284007 CA446863 AL531915 NM_006101

BF667950 AL710845 BE889796 BQ233581 AI954614 AI913466 BI825656 AA211359

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NDC80 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:																	-
SP2:																					-

ECgene alternative splicing isoforms for NDC80

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NDC80 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATATATC

About this image

NDC80 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

See NDC80 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDC80

SOURCE GeneReport for Unigene cluster: Hs.414407

SABiosciences Custom PCR Arrays for NDC80

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDC80

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDC80 gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ndc80^{1 , 5}	NDC80 homolog, kinetochore complex component (S. cerevisiae)^{1, 5}	84.16(n)¹ 83.96(a)¹		17 (41.87 cM)⁵ 67052¹ NM_023294.2¹ NP_075783.2¹ 71496100⁵
chicken (Gallus gallus)	Aves	NDC80¹	NDC80 homolog, kinetochore complex component (S. cerevisiae)	73.27(n) 71.86(a)		395134 NM_204477.2 NP_989808.2
lizard (Anolis carolinensis)	Reptilia	NDC80⁶	--	55(a)	1 ↔ 1	4(40276698-40321276)
African clawed frog (Xenopus laevis)	Amphibia	AY168013.1²	--	74.45(n)		AY168013.1
zebrafish (Danio rerio)	Actinopterygii	ndc80¹	NDC80 homolog, kinetochore complex component (S. cerevisiae)	55.69(n) 46.66(a)		445386 NM_001003863.1 NP_001003863.1
honey bee (Apis mellifera)	Insecta	--	--	9(a)	1 ↔ 1	Group10.17(94812-100134)
worm (Caenorhabditis elegans)	Secernentea	ndc-80¹	Protein NDC-80	43.33(n) 24.9(a)		177873 NM_069429.3 NP_501830.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TID3(YIL144W)⁴ TID3¹	Component of the evolutionarily conserved kinetochore-associated more⁴ Tid3p¹	41.9(n)¹ 23.08(a)¹		9(78074-80149)⁴ 854662^{1, 4} NP_012122.3¹ NP_012122.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G54630¹	kinetochore protein NDC80	41.92(n) 27.63(a)		824628 NM_115320.2 NP_191024.1
rice (Oryza sativa)	Liliopsida	Os08g0468400¹	hypothetical protein	38.83(n) 25.86(a)		4345797 NM_001068543.1 NP_001062008.1

ENSEMBL Gene Tree for NDC80 (if available)
TreeFam Gene Tree for NDC80 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7227863^1,2	C,A,	--	2569673(+)	`GCACAC/GATCAT`	2	--	int¹ us2k¹ tfbs³		0	--	--	--	--
rs76111573^1,2		--	2569740(+)	`TCCCCA/GTATCT`	2	--	us2k¹ int¹		1		EA	120
rs142749757^1,2		--	2569771(+)	`AGAGAC/TGCTGC`	2	--	us2k¹ int¹		0	--	--	--	--
rs2644188^1,2	C,F,O,A,H,	--	2569906(+)	`GAAATG/TAATAG`	2	--	us2k¹ int¹		17		NA NS EA WA CSA	695
rs74337507^1,2	F,	--	2569985(+)	`AAGAGT/ACACCA`	2	--	int¹ us2k¹		1		EA	120
rs151039974^1,2		--	2570008(+)	`CACCCC/TGGCTG`	2	--	us2k¹ int¹		0	--	--	--	--
rs1878553^1,2	C,F,O,A,H,	--	2570155(-)	`AGGATG/AATCAC`	2	--	us2k¹ int¹ tfbs³		28		NA EA MN NS WA CSA	3202
rs186620630^1,2		--	2570174(+)	`TTGGAC/GTCTAG`	2	--	int¹ us2k¹		0	--	--	--	--
rs140872922^1,2		--	2570196(+)	`ACAACA/CGGAAC`	2	--	us2k¹ int¹		0	--	--	--	--
rs147937062^1,2		--	2570308(+)	`GGAAAC/TTGGCA`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NDC80 (2571510 - 2616634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NDC80
1 CNV: 102576
3 Indels: 26020 11913 45636

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NDC80 for disorders           About GeneDecksing

OMIM gene information: 607272    OMIM disorders: --

9 diseases for NDC80:    About MalaCards

retinoblastoma congenital disorder of glycosylation gallbladder carcinoma endometrial cancer

gastric cancer breast carcinoma breast cancer carcinoma

malaria

1 Novoseek disease relationship for NDC80 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	17.9	4	16732327 (1), 12386167 (1), 17330085 (1), 17822787 (1)

Human Genome Epidemiology (HuGE) Navigator: NDC80 (3 documents)

Export disorders for NDC80 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NDC80 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with NDC80)

Utopia: connect your pdf to the dynamic
world of online information

HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. (PubMed id 9315664)^{1, 2, 3, 9} Chen Y.... Lee W.-H. (1997)
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. (PubMed id 12351790)^{1, 2, 3} Martin-Lluesma S.... Nigg E.A. (2002)
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. (PubMed id 12386167)^{1, 2, 9} Chen Y.... Lee W.-H. (2002)
Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PubMed id 16732327)^{1, 2, 9} Lin Y.-T.... Lee W.-H. (2006)
Sgt1 is required for human kinetochore assembly. (PubMed id 15133482)^{1, 2, 9} Steensgaard P.... Musacchio A. (2004)
Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PubMed id 10409732)^{1, 2, 9} Zheng L.... Lee W.-H. (1999)
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. (PubMed id 15964272)^{1, 2} Ahonen L.J.... Gorbsky G.J. (2005)
Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. (PubMed id 15548592)^{1, 2} DeLuca J.G.... McEwen B.F. (2005)
ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)^{1, 2} Kops G.J.P.L.... Cleveland D.W. (2005)
The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. (PubMed id 15713649)^{1, 2} Mikami Y.... Fukagawa T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10403	HGNC: 16909	AceView: KNTC2	Ensembl:ENSG00000080986	euGenes: HUgn10403
ECgene: NDC80	H-InvDB: NDC80

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NDC80	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NDC80 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NDC80 gene:
Search GeneIP for patents involving NDC80

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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