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Aliases for NDC80 Gene

Aliases for NDC80 Gene

  • NDC80 Kinetochore Complex Component 2 3
  • Retinoblastoma-Associated Protein HEC 3 4
  • Highly Expressed In Cancer Protein 3 4
  • Kinetochore-Associated Protein 2 3 4
  • Kinetochore Associated 2 2 3
  • Kinetochore Protein Hec1 3 4
  • HsHec1 3 4
  • KNTC2 3 4
  • HEC1 3 4
  • HEC 3 4
  • Highly Expressed In Cancer, Rich In Leucine Heptad Repeats (Yeast) 2
  • NDC80 Kinetochore Complex Component Homolog (S. Cerevisiae) 2
  • Highly Expressed In Cancer, Rich In Leucine Heptad Repeats 3
  • NDC80 Homolog, Kinetochore Complex Component 3
  • NDC80 Kinetochore Complex Component Homolog 3
  • Kinetochore Protein NDC80 Homolog 3
  • HsNDC80 3
  • TID3 3

External Ids for NDC80 Gene

Previous Symbols for NDC80 Gene

  • KNTC2

Summaries for NDC80 Gene

Entrez Gene Summary for NDC80 Gene

  • This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

GeneCards Summary for NDC80 Gene

NDC80 (NDC80 Kinetochore Complex Component) is a Protein Coding gene. Diseases associated with NDC80 include retinoblastoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NDC80 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Wiki entry for NDC80 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDC80 Gene

Genomics for NDC80 Gene

Genomic Location for NDC80 Gene

Start:
2,571,511 bp from pter
End:
2,616,635 bp from pter
Size:
45,125 bases
Orientation:
Plus strand

Genomic View for NDC80 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDC80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDC80 Gene

Regulatory Elements for NDC80 Gene

Proteins for NDC80 Gene

  • Protein details for NDC80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14777-NDC80_HUMAN
    Recommended name:
    Kinetochore protein NDC80 homolog
    Protein Accession:
    O14777
    Secondary Accessions:
    • Q6PJX2

    Protein attributes for NDC80 Gene

    Size:
    642 amino acids
    Molecular mass:
    73913 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with isoform 1 of NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis.

    Three dimensional structures from OCA and Proteopedia for NDC80 Gene

neXtProt entry for NDC80 Gene

Proteomics data for NDC80 Gene at MOPED

Post-translational modifications for NDC80 Gene

  • Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys26, Lys123, Lys300, Lys360, and Lys462

Other Protein References for NDC80 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDC80 Gene

Domains for NDC80 Gene

Protein Domains for NDC80 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDC80 Gene

Graphical View of Domain Structure for InterPro Entry

O14777

UniProtKB/Swiss-Prot:

NDC80_HUMAN
Family:
  • Belongs to the NDC80/HEC1 family.:
    • O14777
genes like me logo Genes that share domains with NDC80: view

No data available for Gene Families for NDC80 Gene

Function for NDC80 Gene

Molecular function for NDC80 Gene

UniProtKB/Swiss-Prot Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Ontology (GO) - Molecular Function for NDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0005515 protein binding IPI 14699129
GO:0042802 identical protein binding IPI 20360068
genes like me logo Genes that share ontologies with NDC80: view
genes like me logo Genes that share phenotypes with NDC80: view

miRNA for NDC80 Gene

miRTarBase miRNAs that target NDC80

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDC80 Gene

Localization for NDC80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDC80 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDC80 Gene COMPARTMENTS Subcellular localization image for NDC80 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS 9315664
GO:0000776 kinetochore IDA 17363900
GO:0000777 condensed chromosome kinetochore IDA 14699129
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 18195732
GO:0005634 nucleus TAS 9315664
genes like me logo Genes that share ontologies with NDC80: view

Pathways for NDC80 Gene

genes like me logo Genes that share pathways with NDC80: view

Pathways by source for NDC80 Gene

1 GeneGo (Thomson Reuters) pathway for NDC80 Gene
2 BioSystems pathways for NDC80 Gene

Gene Ontology (GO) - Biological Process for NDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation TAS 9315664
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0007052 mitotic spindle organization IMP 14699129
GO:0007059 chromosome segregation IMP 14699129
genes like me logo Genes that share ontologies with NDC80: view

Transcripts for NDC80 Gene

Unigene Clusters for NDC80 Gene

NDC80 kinetochore complex component:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDC80 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: -

Relevant External Links for NDC80 Gene

GeneLoc Exon Structure for
NDC80
ECgene alternative splicing isoforms for
NDC80

Expression for NDC80 Gene

mRNA expression in normal human tissues for NDC80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDC80 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDC80 Gene

SOURCE GeneReport for Unigene cluster for NDC80 Gene Hs.414407

genes like me logo Genes that share expressions with NDC80: view

No data available for mRNA Expression by UniProt/SwissProt for NDC80 Gene

Orthologs for NDC80 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDC80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDC80 35
  • 99.74 (n)
  • 99.69 (a)
NDC80 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDC80 35
  • 90.86 (n)
  • 90.65 (a)
NDC80 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDC80 35
  • 92.16 (n)
  • 92.52 (a)
NDC80 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndc80 35
  • 84.19 (n)
  • 84.09 (a)
Ndc80 16
Ndc80 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDC80 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDC80 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndc80 35
  • 84.36 (n)
  • 85.58 (a)
chicken
(Gallus gallus)
Aves NDC80 35
  • 73.22 (n)
  • 71.86 (a)
NDC80 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDC80 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndc80 35
  • 60.78 (n)
  • 57.73 (a)
Str.15302 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3050 35
zebrafish
(Danio rerio)
Actinopterygii ndc80 35
  • 56.1 (n)
  • 47.74 (a)
ndc80 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndc-80 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TID3 36
  • 20 (a)
OneToOne
TID3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G54630 35
  • 42.25 (n)
  • 28.84 (a)
rice
(Oryza sativa)
Liliopsida Os08g0468400 35
  • 38.34 (n)
  • 25.49 (a)
Species with no ortholog for NDC80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDC80 Gene

ENSEMBL:
Gene Tree for NDC80 (if available)
TreeFam:
Gene Tree for NDC80 (if available)

Paralogs for NDC80 Gene

genes like me logo Genes that share paralogs with NDC80: view

No data available for Paralogs for NDC80 Gene

Variants for NDC80 Gene

Sequence variations from dbSNP and Humsavar for NDC80 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs9051 -- 2,616,458(+) AGATT(C/G)CTAAA missense, reference
rs765594 -- 2,599,209(-) TCACA(C/G)AATTA intron-variant
rs952208 -- 2,584,411(+) TATAG(C/T)AATTT intron-variant
rs1124212 -- 2,613,897(+) ACGAA(A/C)GATTT intron-variant
rs1146049 -- 2,608,073(+) TATCT(G/T)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDC80 Gene

Variant ID Type Subtype PubMed ID
esv2671932 CNV Deletion 23128226
esv1001812 CNV Gain 20482838
esv2487024 CNV Deletion 19546169
esv2716679 CNV Deletion 23290073
esv2089038 CNV Deletion 18987734
nsv131902 CNV Loss 16902084
esv1594787 CNV Deletion 17803354

Relevant External Links for NDC80 Gene

HapMap Linkage Disequilibrium report
NDC80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDC80 Gene

Disorders for NDC80 Gene

(1) MalaCards Diseases for NDC80 Gene

Search for NDC80 Gene in MalaCards »

(1) Novoseek inferred disease relationships for NDC80 Gene

Disease -log(P) Hits PubMed IDs
cancer 17.9 4

Relevant External Links for NDC80

Genetic Association Database (GAD)
NDC80
Human Genome Epidemiology (HuGE) Navigator
NDC80
genes like me logo Genes that share disorders with NDC80: view

No data available for UniProtKB/Swiss-Prot for NDC80 Gene

Publications for NDC80 Gene

  1. HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. (PMID: 9315664) Chen Y. … Lee W.-H. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. (PMID: 10409732) Zheng L. … Lee W.-H. (Mol. Cell. Biol. 1999) 3 4 23
  3. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. (PMID: 12386167) Chen Y. … Lee W.-H. (J. Biol. Chem. 2002) 3 4 23
  4. Sgt1 is required for human kinetochore assembly. (PMID: 15133482) Steensgaard P. … Musacchio A. (EMBO Rep. 2004) 3 4 23
  5. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PMID: 16732327) Lin Y.-T. … Lee W.-H. (Oncogene 2006) 3 4 23

Products for NDC80 Gene

  • Addgene plasmids for NDC80

Sources for NDC80 Gene

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