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Aliases for NDC1 Gene

Aliases for NDC1 Gene

  • NDC1 Transmembrane Nucleoporin 2 3
  • Transmembrane Protein 48 2 3 4
  • TMEM48 3 4
  • Nuclear Division Cycle 1 Homolog (S. Cerevisiae) 2
  • Nuclear Division Cycle 1 Homolog 3
  • Nucleoporin NDC1 3
  • TMEM48, 6
  • HNDC1 4
  • NET3 3

External Ids for NDC1 Gene

Previous Symbols for NDC1 Gene

  • TMEM48

Summaries for NDC1 Gene

GeneCards Summary for NDC1 Gene

NDC1 (NDC1 Transmembrane Nucleoporin) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NDC1 Gene

  • Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

Gene Wiki entry for NDC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDC1 Gene

Genomics for NDC1 Gene

Genomic Location for NDC1 Gene

Start:
53,765,460 bp from pter
End:
53,838,860 bp from pter
Size:
73,401 bases
Orientation:
Minus strand

Genomic View for NDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDC1 Gene

No data available for Regulatory Elements for NDC1 Gene

Proteins for NDC1 Gene

  • Protein details for NDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTX1-NDC1_HUMAN
    Recommended name:
    Nucleoporin NDC1
    Protein Accession:
    Q9BTX1
    Secondary Accessions:
    • B4DHA3
    • B4DQQ5
    • G3XA81
    • Q8NB76
    • Q9H9T6
    • Q9NSG3
    • Q9NSG4
    • Q9NVZ7

    Protein attributes for NDC1 Gene

    Size:
    674 amino acids
    Molecular mass:
    76305 Da
    Quaternary structure:
    • Interacts with the NUP35/NUP53 (By similarity). Interacts with AAAS, anchoring it to the nuclear envelope.
    Miscellaneous:
    • Depletion of NDC1 from HeLa cells interferes with the assembly of phenylalanine-glycine (FG) repeat Nups into nuclear pore complexes
    SequenceCaution:
    • Sequence=BAB14135.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDC1 Gene

neXtProt entry for NDC1 Gene

Proteomics data for NDC1 Gene at MOPED

Post-translational modifications for NDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys379, Lys430, Lys437, and Lys628

Other Protein References for NDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDC1 Gene

Domains for NDC1 Gene

Protein Domains for NDC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NDC1_HUMAN
Family:
  • Belongs to the NDC1 family.:
    • Q9BTX1
genes like me logo Genes that share domains with NDC1: view

No data available for Gene Families for NDC1 Gene

Function for NDC1 Gene

Molecular function for NDC1 Gene

UniProtKB/Swiss-Prot Function: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

Gene Ontology (GO) - Molecular Function for NDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017056 structural constituent of nuclear pore IMP 16600873
genes like me logo Genes that share ontologies with NDC1: view
genes like me logo Genes that share phenotypes with NDC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDC1 Gene

Localization for NDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDC1 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.

Gene Ontology (GO) - Cellular Components for NDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IDA 16600873
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NDC1: view

Pathways for NDC1 Gene

SuperPathways for NDC1 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with NDC1: view

Pathways by source for NDC1 Gene

1 KEGG pathway for NDC1 Gene

Interacting Proteins for NDC1 Gene

Gene Ontology (GO) - Biological Process for NDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007129 synapsis IEA --
GO:0007283 spermatogenesis IEA --
GO:0015031 protein transport NAS 16600873
GO:0031081 nuclear pore distribution IMP 16600873
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NDC1: view

Transcripts for NDC1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - - - - - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NDC1 Gene

GeneLoc Exon Structure for
NDC1
ECgene alternative splicing isoforms for
NDC1

Expression for NDC1 Gene

mRNA expression in normal human tissues for NDC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NDC1 Gene

genes like me logo Genes that share expressions with NDC1: view

Orthologs for NDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM48 36
  • 99.41 (n)
  • 98.96 (a)
TMEM48 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDC1 36
  • 90.65 (n)
  • 91.1 (a)
NDC1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDC1 36
  • 91.54 (n)
  • 92.28 (a)
NDC1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndc1 36
  • 86.16 (n)
  • 87.5 (a)
Ndc1 37
  • 87 (a)
OneToOne
Tmem48 16
oppossum
(Monodelphis domestica)
Mammalia NDC1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDC1 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndc1 36
  • 86.66 (n)
  • 87.35 (a)
chicken
(Gallus gallus)
Aves NDC1 37
  • 59 (a)
OneToOne
TMEM48 36
  • 69.94 (n)
  • 70.86 (a)
lizard
(Anolis carolinensis)
Reptilia NDC1 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14211 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndc1 36
  • 63 (n)
  • 60.37 (a)
Str.20452 36
zebrafish
(Danio rerio)
Actinopterygii ndc1 36
  • 60.02 (n)
  • 55.8 (a)
ndc1 37
  • 53 (a)
OneToOne
wufk93f04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004558 36
  • 43.43 (n)
  • 27.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32246 37
  • 17 (a)
OneToMany
CG5857 36
  • 39.6 (n)
  • 27 (a)
CG5857 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-22 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
CSA.4001 37
  • 35 (a)
OneToMany
Species with no ortholog for NDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDC1 Gene

ENSEMBL:
Gene Tree for NDC1 (if available)
TreeFam:
Gene Tree for NDC1 (if available)

Paralogs for NDC1 Gene

No data available for Paralogs for NDC1 Gene

Variants for NDC1 Gene

Sequence variations from dbSNP and Humsavar for NDC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1181145 -- 53,806,657(-) TTTAT(A/G)TAACT intron-variant
rs1181146 -- 53,806,390(+) AGAGA(A/T)AACTG intron-variant
rs1181147 -- 53,803,414(-) GTACA(C/T)TGACA intron-variant
rs1181148 -- 53,803,200(-) TAGTC(C/G)CAGCT intron-variant
rs1181149 -- 53,802,864(-) AAGAA(A/T)CTAGA intron-variant

Relevant External Links for NDC1 Gene

HapMap Linkage Disequilibrium report
NDC1

No data available for Structural Variations from Database of Genomic Variants (DGV) for NDC1 Gene

Disorders for NDC1 Gene

No disorders were found for NDC1 Gene.

No data available for UniProtKB/Swiss-Prot for NDC1 Gene

Publications for NDC1 Gene

  1. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PMID: 16600873) Mansfeld J. … Antonin W. (Mol. Cell 2006) 3 4
  5. NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. (PMID: 16702233) Stavru F. … GAPrlich D. (J. Cell Biol. 2006) 3 4

Products for NDC1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDC1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDC1
    • Block miRNA regulation of NDC1 using miScript Target Protectors

    Sources for NDC1 Gene

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