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Aliases for NCS1 Gene

Aliases for NCS1 Gene

  • Neuronal Calcium Sensor 1 2 3 5
  • Frequenin-Like Ubiquitous Protein 3 4
  • Frequenin-Like Protein 3 4
  • Frequenin Homolog 3 4
  • FREQ 3 4
  • FLUP 3 4
  • Frequenin (Drosophila) Homolog 2
  • Frequenin Homolog (Drosophila) 2
  • NCS-1 4

External Ids for NCS1 Gene

Previous HGNC Symbols for NCS1 Gene

  • FREQ

Previous GeneCards Identifiers for NCS1 Gene

  • GC09P132934
  • GC09P102535

Summaries for NCS1 Gene

Entrez Gene Summary for NCS1 Gene

  • This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCS1 Gene

NCS1 (Neuronal Calcium Sensor 1) is a Protein Coding gene. Diseases associated with NCS1 include Labyrinthitis and Tracheitis. Among its related pathways are Ca, cAMP and Lipid Signaling and Neuroscience. GO annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is HPCAL1.

UniProtKB/Swiss-Prot for NCS1 Gene

  • Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

Gene Wiki entry for NCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCS1 Gene

Genomics for NCS1 Gene

Regulatory Elements for NCS1 Gene

Enhancers for NCS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F130110 0.7 ENCODE 17.6 -61.9 -61901 1.1 SCRT1 ZNF121 CTCF SCRT2 SMC3 ZIC2 PRDM1 RAD21 NCS1 LOC401554 TOR1A USP20 C9orf78 ENSG00000230684 GC09P130107 ENSG00000223188
GH09F130117 1.1 Ensembl ENCODE 17.1 -53.4 -53367 4.0 SIN3A ZNF121 SMARCC2 FOS ZNF263 SMARCC1 ZEB2 SMARCA4 IKZF1 KDM1A USP20 NCS1 TOR1A LOC401554 ENSG00000230684 C9orf78 FNBP1 ENSG00000223188 GC09P130107
GH09F130126 1 Ensembl ENCODE 16.9 -43.0 -43034 5.8 PKNOX1 SIN3A FEZF1 BRCA1 GLIS2 FOS DEK JUNB REST TBX21 USP20 NCS1 TOR1A C9orf78 ENSG00000230684 PRDM12 TOR1B ENSG00000223188 PIR46934
GH09F130111 0.4 ENCODE 16.4 -60.0 -60044 1.3 BCOR HDAC1 CBX3 ARNT TAL1 ZMYM3 ZNF121 POLR2A GATA2 NCOR1 NCS1 C9orf78 LOC401554 ENSG00000230684 USP20 TOR1A GC09P130107 ENSG00000223188
GH09F130149 0.6 ENCODE 13.1 -22.7 -22661 0.4 BCOR PKNOX1 CBX3 DDX20 NR2F1 ZMYM3 ZBTB7A NFYB PBX2 KDM1A NCS1 GC09P130152 GC09M130147
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NCS1 on UCSC Golden Path with GeneCards custom track

Promoters for NCS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001315720 122 2201 SIN3A RAD21 GLIS2 FOS EGR2 ZNF263 CEBPB ZEB2 ZFP69B ZNF341

Genomic Location for NCS1 Gene

Chromosome:
9
Start:
130,172,578 bp from pter
End:
130,237,304 bp from pter
Size:
64,727 bases
Orientation:
Plus strand

Genomic View for NCS1 Gene

Genes around NCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCS1 Gene

Proteins for NCS1 Gene

  • Protein details for NCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62166-NCS1_HUMAN
    Recommended name:
    Neuronal calcium sensor 1
    Protein Accession:
    P62166
    Secondary Accessions:
    • E9PAY3
    • P36610
    • Q9UK26

    Protein attributes for NCS1 Gene

    Size:
    190 amino acids
    Molecular mass:
    21879 Da
    Quaternary structure:
    • Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1.
    Miscellaneous:
    • Binds 3 calcium ions via the second, third and fourth EF-hand.

    Three dimensional structures from OCA and Proteopedia for NCS1 Gene

    Alternative splice isoforms for NCS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCS1 Gene

Post-translational modifications for NCS1 Gene

  • Ubiquitination at Lys 25 and Lys 53
  • Modification sites at PhosphoSitePlus

Other Protein References for NCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCS1 (FREQ)

No data available for DME Specific Peptides for NCS1 Gene

Domains & Families for NCS1 Gene

Gene Families for NCS1 Gene

Protein Domains for NCS1 Gene

Suggested Antigen Peptide Sequences for NCS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62166

UniProtKB/Swiss-Prot:

NCS1_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with NCS1: view

Function for NCS1 Gene

Molecular function for NCS1 Gene

UniProtKB/Swiss-Prot Function:
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

Gene Ontology (GO) - Molecular Function for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0005245 voltage-gated calcium channel activity ISS --
GO:0005509 calcium ion binding TAS 11092894
GO:0005515 protein binding IPI 12783849
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with NCS1: view
genes like me logo Genes that share phenotypes with NCS1: view

Animal Models for NCS1 Gene

MGI Knock Outs for NCS1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCS1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCS1 Gene

Localization for NCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCS1 Gene

Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305 PubMed:17555535}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCS1 Gene COMPARTMENTS Subcellular localization image for NCS1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
golgi apparatus 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12783849
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA,IDA 12783849
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with NCS1: view

Pathways & Interactions for NCS1 Gene

genes like me logo Genes that share pathways with NCS1: view

Pathways by source for NCS1 Gene

2 Cell Signaling Technology pathways for NCS1 Gene

Gene Ontology (GO) - Biological Process for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010975 regulation of neuron projection development ISS --
GO:0045921 positive regulation of exocytosis IEA --
GO:0048015 phosphatidylinositol-mediated signaling IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with NCS1: view

No data available for SIGNOR curated interactions for NCS1 Gene

Drugs & Compounds for NCS1 Gene

(3) Drugs for NCS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for NCS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCS1: view

Transcripts for NCS1 Gene

Unigene Clusters for NCS1 Gene

Neuronal calcium sensor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCS1 Gene

No ASD Table

Relevant External Links for NCS1 Gene

GeneLoc Exon Structure for
NCS1
ECgene alternative splicing isoforms for
NCS1

Expression for NCS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCS1 Gene

This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Hippocampus (x5.2), Brain - Cortex (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for NCS1 Gene

This gene is overexpressed in Bone (30.1), Brain (8.7), and Frontal cortex (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NCS1 Gene:

NCS1

SOURCE GeneReport for Unigene cluster for NCS1 Gene:

Hs.642946
genes like me logo Genes that share expression patterns with NCS1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NCS1 Gene

Orthologs for NCS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCS1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia NCS1 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCS1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCS1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCS1 34 35
  • 91.25 (n)
mouse
(Mus musculus)
Mammalia Ncs1 34 16 35
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Ncs1 34
  • 89.47 (n)
cow
(Bos Taurus)
Mammalia NCS1 34 35
  • 88.21 (n)
chicken
(Gallus gallus)
Aves NCS1 34 35
  • 88.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncs1 34
  • 83.68 (n)
MGC75953 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8594 34
zebrafish
(Danio rerio)
Actinopterygii ncs1b 34 35
  • 82.81 (n)
zgc63620 34
fruit fly
(Drosophila melanogaster)
Insecta Frq1 35
  • 72 (a)
OneToMany
Frq2 34 35
  • 67.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013126 34
  • 62.65 (n)
worm
(Caenorhabditis elegans)
Secernentea ncs-1 34 35
  • 66.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL163W 34
  • 63.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRQ1 34 35 37
  • 57.54 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02399g 34
  • 56.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2434 35
  • 68 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04379 34
  • 64.21 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ncs1 34
  • 60.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15607 34
Species where no ortholog for NCS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCS1 Gene

ENSEMBL:
Gene Tree for NCS1 (if available)
TreeFam:
Gene Tree for NCS1 (if available)

Paralogs for NCS1 Gene

(18) SIMAP similar genes for NCS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCS1: view

Variants for NCS1 Gene

Sequence variations from dbSNP and Humsavar for NCS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001742 -- 130,216,809(-) GGGCC(C/T)GACGC intron-variant
rs1009502 -- 130,193,950(+) GGTGC(A/G)GTTTT intron-variant
rs10116126 -- 130,228,672(+) ctttc(C/T)ttttt intron-variant
rs10116435 -- 130,225,737(+) TGAGC(A/G)CAGCT intron-variant
rs10118212 -- 130,220,517(+) GGGGG(C/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCS1 Gene

Variant ID Type Subtype PubMed ID
dgv12908n54 CNV loss 21841781
dgv4148n106 CNV deletion 24896259
esv2761559 CNV gain 21179565
esv3621857 CNV loss 21293372
nsv1046307 CNV gain 25217958
nsv1075275 CNV deletion 25765185
nsv1075681 CNV deletion 25765185
nsv466590 CNV gain 19166990
nsv466592 CNV loss 19166990
nsv466593 CNV loss 19166990
nsv466595 CNV gain 19166990
nsv471825 CNV novel sequence insertion 20440878
nsv520802 CNV gain+loss 19592680
nsv615498 CNV gain 21841781
nsv615499 CNV loss 21841781
nsv615502 CNV loss 21841781
nsv615503 CNV loss 21841781
nsv615504 CNV gain 21841781
nsv6732 CNV deletion 18451855
nsv831733 CNV loss 17160897

Variation tolerance for NCS1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCS1 Gene

Human Gene Mutation Database (HGMD)
NCS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCS1 Gene

Disorders for NCS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NCS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
labyrinthitis
  • labyrinthine disorder
tracheitis
  • acute tracheitis
denture stomatitis
  • denture sore mouth
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search NCS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCS1

Genetic Association Database (GAD)
NCS1
Human Genome Epidemiology (HuGE) Navigator
NCS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCS1
genes like me logo Genes that share disorders with NCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCS1 Gene

Publications for NCS1 Gene

  1. Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). (PMID: 11092894) Bourne Y. … Pongs O. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. (PMID: 12783849) Bahi N. … Chelly J. (Hum. Mol. Genet. 2003) 3 4 22 64
  3. A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. (PMID: 11606724) Nakamura T.Y. … Coetzee W.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 22 64
  4. Membrane binding of Neuronal Calcium Sensor-1 (NCS1). (PMID: 26705828) Lemire S. … Boisselier A.8. (Colloids Surf B Biointerfaces 2016) 2 3 64
  5. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. (PMID: 20479890) Handley M.T. … Burgoyne R.D. (PLoS ONE 2010) 3 22 64

Products for NCS1 Gene

Sources for NCS1 Gene

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