NCS1 Gene
protein-coding GIFtS: 57
GCID: GC09P132934
|
|
neuronal calcium sensor 1(Previous names: frequenin (Drosophila) homolog, frequenin homolog (Drosophila)...)
(Previous symbol: FREQ)
| |
Aliases
for NCS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuronal Calcium Sensor 11 2 | | Frequenin-Like Ubiquitous Protein2 3 | | FREQ1 2 3 5 | | FLUP2 3 | | NCS-11 3 | | Frequenin (Drosophila) Homolog1 | | Frequenin Homolog2 3 | | Frequenin Homolog (Drosophila)1 | | Frequenin-Like Protein2 3 | | |
Export aliases for NCS1 gene to outside databasesPrevious GC identifer: GC09P102535 |
Summaries
for NCS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCS1:
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressedpredominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in acalcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules andmodulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NCS1_HUMAN, P62166Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependentmanner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity).Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interactionwith PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity ofN-type voltage-gated calcium channel (By similarity)
Gene Wiki entry for NCS1 (Neuronal calcium sensor-1)
|
Genomic Views
for NCS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NCS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11NCS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P132934: view genomic region
(about GC identifiers)
Start:
|
132,934,857 bp from pter |
End:
|
132,999,583 bp from pter |
Size:
|
64,727 bases |
Orientation:
|
plus strand |
|
Proteins
for NCS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCS1_HUMAN, P62166 (See
protein sequence)Recommended Name: Neuronal calcium sensor 1 Size: 190 amino acids; 21879 Da
Subunit: Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes withCALN2/CABP7 binding to PI4KB (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in acalcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1
Subcellular location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse,postsynaptic cell membrane, postsynaptic density (By similarity). Cytoplasm, perinuclear region. Cell membrane;Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in thepre-synaptic nerve terminal at neuromuscular junctions
Miscellaneous: Binds 3 calcium ions via the second, third and fourth EF-hand
2 PDB 3D structures from  and Proteopedia  for NCS1:1G8I (3D)
2LCP (3D)
Secondary accessions: E9PAY3 P36610 Q9UK26Alternative splicing: 2 isoforms: P62166-1 P62166-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NCS1: NX_P62166
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62166
NCS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001122298.1 NP_055101.2
ENSEMBL proteins: ENSP00000361475 ENSP00000404103
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
NCS1 for ontologies About GeneDecksing
NCS1 Antibody Products:
Assay Products for NCS1: |
Protein
Domains /
Families
for NCS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCS1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62166ProtoNet protein and cluster: P62166 UniProtKB/Swiss-Prot: NCS1_HUMAN, P62166Similarity: Belongs to the recoverin familySimilarity: Contains 4 EF-hand domains |
Function
for NCS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NCS1_HUMAN, P62166Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependentmanner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity).Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interactionwith PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity ofN-type voltage-gated calcium channel (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NCS1 (NM_014286) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCS1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NCS1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ncs1tm1Blt for NCS1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ncs1):
NCS1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NCS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Neuroscience | | | 2 | Synaptic transmission: ion currents | | | 3 | Ca, cAMP and Lipid Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NCS1
2 
Cell Signaling Technology (CST) Pathways for NCS1
NCS1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/25 Interacting proteins for NCS1 (P621662, 3 ENSP000003614754) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010975 | regulation of neuron projection development |
ISS | -- | | GO:0045921 | positive regulation of exocytosis |
IEA | -- | | GO:0048015 | phosphatidylinositol-mediated signaling |
IEA | -- | | GO:0051927 | negative regulation of calcium ion transport via voltage-gated calcium channel activity |
-- | -- |
NCS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCS1 for compounds About GeneDecksing
 Browse Tocris compounds for NCS1
1 HMDB Compound for NCS1 About this table
7 Novoseek chemical compound relationships for NCS1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
54 |
53 |
12034721 (4), 18634883 (3), 15699030 (3), 11910115 (3) (see all 22) |
| phosphatidylinositol |
49.7 |
14 |
16014415 (2), 14512421 (2), 12034721 (1), 15659215 (1) (see all 8) |
| phosphoinositide |
48.4 |
6 |
12034721 (1), 17114292 (1), 15659215 (1), 16691292 (1) (see all 5) |
| inositol 1,4,5 trisphosphate |
43.8 |
3 |
17114292 (2), 19732951 (1) |
| dopamine |
14.6 |
4 |
12351722 (1), 15364041 (1), 17763944 (1) |
| lipid |
0 |
2 |
15659215 (1), 11526106 (1) |
| potassium |
0 |
1 |
16733800 (1) |
Search CenterWatch for drugs/clinical trials and news about NCS1
|
Transcripts
for NCS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCS1 gene (2 alternative transcripts): NM_001128826.1 NM_014286.3 Unigene Cluster for NCS1: Neuronal calcium sensor 1 Hs.642946 [show with all ESTs]Unigene Representative Sequence: NM_0142863 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372398(uc004bzi.2) ENST00000493042 ENST00000458469(uc010myz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NCS1 (NM_014286) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCS1 |
Additional cDNA sequence: AF134479.1 AF186409.1 AK023889.1 AK024709.1 AL161981.1 BC004856.2 BC008698.1 X84048.1 9 DOTS entries: DT.446408 DT.101983685 DT.95077340 DT.100785967 DT.100785971 DT.91823615 DT.95077338 DT.91723247 DT.91906344 24/305 AceView cDNA sequences (see all 305): BF116040 CA396017 BM797243 CB155131 BQ880305 F04592 BF221752 CR597605 F04130 F13357 BE552372 BU150740 CR612062 BQ881768 AW007187 BF940109 AI937792 BM559024 BM128579 BF115916 AI391466 AI492390 BM719015 CB156295
GeneLoc Exon Structure
|
Expression
for NCS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCATAGTCC
About this image
See NCS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCS1
SOURCE GeneReport for Unigene cluster: Hs.642946
SABiosciences Custom PCR Arrays for NCS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCS1 |
Orthologs
for NCS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NCS1 gene from 5/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NCS11 |
neuronal calcium sensor 1 |
88.6(n)
100(a) |
|
396336 NM_205377.1 NP_990708.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.85942 |
Xenopus laevis frequenin mRNA, complete cds |
82.7(n) |
|
U27274.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636202 |
hypothetical protein MGC63620 |
80.48(n) |
|
393437 AY190280.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Frq21 |
Frequenin 2 |
67.93(n)
71.74(a) |
|
32799 NM_080354.3 NP_525093.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
ncs-11 |
Protein NCS-1 |
66.67(n)
75.66(a) |
|
180448 NM_075785.1 NP_508186.1 |
ENSEMBL Gene Tree for NCS1 (if available)
TreeFam Gene Tree for NCS1 (if available) |
Paralogs
for NCS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCS1 gene
- HPCA2 KCNIP32 KCNIP42 GUCA1A2 KCNIP12 RCVRN2 HPCAL12 GUCA1B2
- NCALD2 KCNIP22 HPCAL42 VSNL12 GUCA1C2
18/19 SIMAP similar genes for NCS1 using alignment to 1 protein entry: NCS1_HUMAN(see all similar genes):HPCAL1 DKFZp781K1922 HPCA NCALD VSNL1 HPCAL4
KCNIP4 KCNIP3 KCNIP2 RCV1 RCVRN KCNIP1
GUCA1B DKFZp686E1183 GUCA1A HZGJ PPP3R1 PPP3R2
NCS1 for paralogs About GeneDecksing
|
Genomic Variants
for NCS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCS1 (132934857 - 132999583 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NCS1: --
Human Gene Mutation Database (HGMD): NCS1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCS1 |
|
Disorders
/ Diseases
for NCS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCS1 for disorders About GeneDecksing
OMIM gene information: 603315
OMIM disorders: --
10  diseases for NCS1: About MalaCardsneuronitis denture stomatitis tracheitis anorexia nervosa
labyrinthitis bipolar disorder stomatitis schizophrenia
cerebritis pancreatitis
1 disease from the University of Copenhagen DISEASES database for NCS1:Labyrinthine dysfunction 3 Novoseek disease relationships for NCS1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
28.2 |
9 |
15364041 (6), 19091302 (1), 19656467 (1) |
| mental retardation |
21.1 |
1 |
19656467 (1) |
| shock |
0 |
1 |
8101711 (1) |
Human Genome Epidemiology (HuGE) Navigator: NCS1 (3 documents)
Export disorders for NCS1 gene to outside databases
|
Publications
for NCS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCS1 gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with NCS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). (PubMed id 11092894)1, 2, 3, 9 Bourne Y.... Pongs O. (2001)
- A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. (PubMed id 11606724)1, 2, 9 Nakamura T.Y....Coetzee W.A. (2001)
- IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. (PubMed id 12783849)1, 2, 9 Bahi N.... Chelly J. (2003)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients. (PubMed id 19091302)1, 9 Torres K.C....Romano-Silva M.A. (2009)
- Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1. (PubMed id 14512421)1, 9 Strahl T....Pongs O. (2003)
- Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. (PubMed id 12351722)1, 9 Kabbani N....Levenson R. (2002)
- Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells. (PubMed id 11526106)1, 9 Zhao X....Balla T. (2001)
- Structural and functional deficits in a neuronal calc ium sensor-1 mutant identified in a case of autistic spectrum disorder. (PubMed id 20479890)1, 9 Handley M.T....Burgoyne R.D. (2010)
|
External Searches for NCS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NCS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NCS1 gene:
Search GeneIP for patents involving NCS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for NCS1 | | OriGene shRNA RFP for NCS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCS1 | | | OriGene Protein Over-expression Lysate for NCS1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCS1 | | OriGene 3'-UTR Clone for NCS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NCS1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NCS1 | | OriGene Custom Protein Services for NCS1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCS1 |
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| | Antibodies & Assays for NCS1 (FREQ) |
| | | | Search Tocris compounds for NCS1 |
| |  |  |  |  | | | | | | Recombinant Protein for NCS1 |
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 | | | NCS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCS1 |
|  |  |  | | | | ThermoFisher Antibodies for NCS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCS1 |
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