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Aliases for NCS1 Gene

Aliases for NCS1 Gene

  • Neuronal Calcium Sensor 1 2 3 5
  • Frequenin-Like Ubiquitous Protein 3 4
  • Frequenin-Like Protein 3 4
  • Frequenin Homolog 3 4
  • FREQ 3 4
  • FLUP 3 4
  • Frequenin (Drosophila) Homolog 2
  • Frequenin Homolog (Drosophila) 2
  • NCS-1 4

External Ids for NCS1 Gene

Previous HGNC Symbols for NCS1 Gene

  • FREQ

Previous GeneCards Identifiers for NCS1 Gene

  • GC09P132934
  • GC09P102535

Summaries for NCS1 Gene

Entrez Gene Summary for NCS1 Gene

  • This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCS1 Gene

NCS1 (Neuronal Calcium Sensor 1) is a Protein Coding gene. Diseases associated with NCS1 include schizophrenia. GO annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for NCS1 Gene

  • Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

Gene Wiki entry for NCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCS1 Gene

Genomics for NCS1 Gene

Regulatory Elements for NCS1 Gene

Promoters for NCS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCS1 Gene

Chromosome:
9
Start:
130,172,578 bp from pter
End:
130,237,304 bp from pter
Size:
64,727 bases
Orientation:
Plus strand

Genomic View for NCS1 Gene

Genes around NCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCS1 Gene

Proteins for NCS1 Gene

  • Protein details for NCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62166-NCS1_HUMAN
    Recommended name:
    Neuronal calcium sensor 1
    Protein Accession:
    P62166
    Secondary Accessions:
    • E9PAY3
    • P36610
    • Q9UK26

    Protein attributes for NCS1 Gene

    Size:
    190 amino acids
    Molecular mass:
    21879 Da
    Quaternary structure:
    • Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1.
    Miscellaneous:
    • Binds 3 calcium ions via the second, third and fourth EF-hand.

    Three dimensional structures from OCA and Proteopedia for NCS1 Gene

    Alternative splice isoforms for NCS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCS1 Gene

Proteomics data for NCS1 Gene at MOPED

Post-translational modifications for NCS1 Gene

  • Ubiquitination at Lys 25 and Lys 53
  • Modification sites at PhosphoSitePlus

Other Protein References for NCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCS1 (FREQ)

No data available for DME Specific Peptides for NCS1 Gene

Domains & Families for NCS1 Gene

Gene Families for NCS1 Gene

Protein Domains for NCS1 Gene

Suggested Antigen Peptide Sequences for NCS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62166

UniProtKB/Swiss-Prot:

NCS1_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with NCS1: view

Function for NCS1 Gene

Molecular function for NCS1 Gene

UniProtKB/Swiss-Prot Function:
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
genes like me logo Genes that share phenotypes with NCS1: view

Animal Models for NCS1 Gene

MGI Knock Outs for NCS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCS1 Gene

Localization for NCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCS1 Gene

Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305 PubMed:17555535}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCS1 Gene COMPARTMENTS Subcellular localization image for NCS1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
golgi apparatus 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12783849
GO:0005829 cytosol IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0031045 dense core granule IEA --
genes like me logo Genes that share ontologies with NCS1: view

Pathways & Interactions for NCS1 Gene

SuperPathways for NCS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048015 phosphatidylinositol-mediated signaling IEA --
genes like me logo Genes that share ontologies with NCS1: view

No data available for Pathways by source and SIGNOR curated interactions for NCS1 Gene

Drugs & Compounds for NCS1 Gene

(3) Drugs for NCS1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for NCS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCS1: view

Transcripts for NCS1 Gene

Unigene Clusters for NCS1 Gene

Neuronal calcium sensor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCS1 Gene

No ASD Table

Relevant External Links for NCS1 Gene

GeneLoc Exon Structure for
NCS1
ECgene alternative splicing isoforms for
NCS1

Expression for NCS1 Gene

mRNA expression in normal human tissues for NCS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCS1 Gene

This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Hippocampus (x5.2), Brain - Cortex (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for NCS1 Gene

This gene is overexpressed in Bone (30.1), Brain (8.7), and Frontal cortex (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCS1 Gene



SOURCE GeneReport for Unigene cluster for NCS1 Gene Hs.642946

genes like me logo Genes that share expression patterns with NCS1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NCS1 Gene

Orthologs for NCS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCS1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCS1 36
  • 100 (a)
OneToOne
NCS1 35
  • 88.21 (n)
  • 94.48 (a)
dog
(Canis familiaris)
Mammalia NCS1 35
  • 91.25 (n)
  • 100 (a)
NCS1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncs1 36
  • 100 (a)
OneToOne
Ncs1 16
Ncs1 35
  • 90.35 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NCS1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCS1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncs1 35
  • 89.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves NCS1 36
  • 100 (a)
OneToOne
NCS1 35
  • 88.6 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8594 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncs1 35
  • 83.68 (n)
  • 99.47 (a)
MGC75953 35
zebrafish
(Danio rerio)
Actinopterygii zgc63620 35
ncs1b 35
  • 82.81 (n)
  • 97.89 (a)
ncs1b 36
  • 98 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013126 35
  • 62.65 (n)
  • 73.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Frq2 36
  • 71 (a)
OneToMany
Frq1 36
  • 72 (a)
OneToMany
Frq2 35
  • 67.93 (n)
  • 71.74 (a)
worm
(Caenorhabditis elegans)
Secernentea ncs-1 36
  • 75 (a)
OneToOne
ncs-1 35
  • 66.67 (n)
  • 75.66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL163W 35
  • 63.51 (n)
  • 61.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRQ1 38
FRQ1 36
  • 60 (a)
OneToMany
FRQ1 35
  • 57.54 (n)
  • 60 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02399g 35
  • 56.14 (n)
  • 59.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04379 35
  • 64.21 (n)
  • 65.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ncs1 35
  • 60.53 (n)
  • 69.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15607 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2434 36
  • 68 (a)
OneToOne
Species with no ortholog for NCS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCS1 Gene

ENSEMBL:
Gene Tree for NCS1 (if available)
TreeFam:
Gene Tree for NCS1 (if available)

Paralogs for NCS1 Gene

(18) SIMAP similar genes for NCS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCS1: view

Variants for NCS1 Gene

Sequence variations from dbSNP and Humsavar for NCS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs709611 -- 130,236,080(+) ATCTC(C/T)TCCCC utr-variant-3-prime
rs870810 -- 130,206,773(+) TGCCT(C/T)TCTCT intron-variant
rs870811 -- 130,206,805(+) AGCCC(A/C)GGCTT intron-variant
rs740917 -- 130,192,323(+) CTGCC(A/G)CCCTT intron-variant
rs740918 -- 130,192,893(-) CCGCA(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCS1 Gene

Variant ID Type Subtype PubMed ID
nsv831733 CNV Loss 17160897
nsv466590 CNV Gain 19166990
nsv6732 CNV Loss 18451855
nsv520802 CNV Gain+Loss 19592680
nsv893932 CNV Loss 21882294
nsv893933 CNV Gain 21882294
nsv893934 CNV Loss 21882294
nsv893935 CNV Loss 21882294
nsv466592 CNV Loss 19166990
dgv8300n71 CNV Loss 21882294
nsv466593 CNV Loss 19166990
dgv8301n71 CNV Loss 21882294
nsv893940 CNV Gain 21882294
nsv466595 CNV Gain 19166990

Variation tolerance for NCS1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCS1 Gene

HapMap Linkage Disequilibrium report
NCS1
Human Gene Mutation Database (HGMD)
NCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCS1 Gene

Disorders for NCS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search NCS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCS1

Genetic Association Database (GAD)
NCS1
Human Genome Epidemiology (HuGE) Navigator
NCS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCS1
genes like me logo Genes that share disorders with NCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCS1 Gene

Publications for NCS1 Gene

  1. Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). (PMID: 11092894) Bourne Y. … Pongs O. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. (PMID: 20479890) Handley M.T. … Burgoyne R.D. (PLoS ONE 2010) 3 23
  3. Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients. (PMID: 19091302) Torres K.C. … Romano-Silva M.A. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2009) 3 23
  4. Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment. (PMID: 16837555) Kapp-Barnea Y. … Sagi-Eisenberg R. (Mol. Biol. Cell 2006) 3 23
  5. Identification and subcellular localization of neuronal calcium sensor-1 (NCS-1) in human neutrophils and HL-60 cells. (PMID: 14760944) Brochetta C. … Zabucchi G. (Inflammation 2003) 3 23

Products for NCS1 Gene

Sources for NCS1 Gene

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