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Aliases for NCS1 Gene

Aliases for NCS1 Gene

  • Neuronal Calcium Sensor 1 2 3
  • Frequenin-Like Ubiquitous Protein 3 4
  • Frequenin-Like Protein 3 4
  • Frequenin Homolog 3 4
  • FREQ 3 4
  • FLUP 3 4
  • Frequenin (Drosophila) Homolog 2
  • Frequenin Homolog (Drosophila) 2
  • FREQ, 6
  • NCS-1 4

External Ids for NCS1 Gene

Previous HGNC Symbols for NCS1 Gene

  • FREQ

Previous GeneCards Identifiers for NCS1 Gene

  • GC09P132934
  • GC09P102535

Summaries for NCS1 Gene

Entrez Gene Summary for NCS1 Gene

  • This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCS1 Gene

NCS1 (Neuronal Calcium Sensor 1) is a Protein Coding gene. Among its related pathways are Neuroscience and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for NCS1 Gene

  • Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

Gene Wiki entry for NCS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCS1 Gene

Genomics for NCS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCS1 Gene

Start:
130,172,578 bp from pter
End:
130,237,304 bp from pter
Size:
64,727 bases
Orientation:
Plus strand

Genomic View for NCS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCS1 Gene

No data available for Regulatory Elements for NCS1 Gene

Proteins for NCS1 Gene

  • Protein details for NCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62166-NCS1_HUMAN
    Recommended name:
    Neuronal calcium sensor 1
    Protein Accession:
    P62166
    Secondary Accessions:
    • E9PAY3
    • P36610
    • Q9UK26

    Protein attributes for NCS1 Gene

    Size:
    190 amino acids
    Molecular mass:
    21879 Da
    Quaternary structure:
    • Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB (By similarity). Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain) (By similarity). Interacts with IL1RAPL1.
    Miscellaneous:
    • Binds 3 calcium ions via the second, third and fourth EF-hand

    Three dimensional structures from OCA and Proteopedia for NCS1 Gene

    Alternative splice isoforms for NCS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCS1 Gene

Proteomics data for NCS1 Gene at MOPED

Post-translational modifications for NCS1 Gene

  • Ubiquitination at Lys25 and Lys53
  • Modification sites at PhosphoSitePlus

Other Protein References for NCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCS1 (FREQ)

No data available for DME Specific Peptides for NCS1 Gene

Domains for NCS1 Gene

Gene Families for NCS1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for NCS1 Gene

Suggested Antigen Peptide Sequences for NCS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62166

UniProtKB/Swiss-Prot:

NCS1_HUMAN :
  • P62166
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with NCS1: view

Function for NCS1 Gene

Molecular function for NCS1 Gene

UniProtKB/Swiss-Prot Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

Gene Ontology (GO) - Molecular Function for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0005245 voltage-gated calcium channel activity ISS --
GO:0005509 calcium ion binding TAS 11092894
GO:0005515 protein binding IPI 12783849
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with NCS1: view

Phenotypes for NCS1 Gene

MGI mutant phenotypes for NCS1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NCS1: view

Animal Models for NCS1 Gene

MGI Knock Outs for NCS1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NCS1 Gene

Localization for NCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCS1 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCS1 Gene COMPARTMENTS Subcellular localization image for NCS1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12783849
GO:0005794 Golgi apparatus --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with NCS1: view

Pathways for NCS1 Gene

genes like me logo Genes that share pathways with NCS1: view

Pathways by source for NCS1 Gene

2 Cell Signaling Technology pathways for NCS1 Gene

Gene Ontology (GO) - Biological Process for NCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010975 regulation of neuron projection development ISS --
GO:0045921 positive regulation of exocytosis IEA --
GO:0048015 phosphatidylinositol-mediated signaling IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with NCS1: view

Compounds for NCS1 Gene

(1) HMDB Compounds for NCS1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(7) Novoseek inferred chemical compound relationships for NCS1 Gene

Compound -log(P) Hits PubMed IDs
calcium 54 37
phosphatidylinositol 49.7 10
phosphoinositide 48.4 5
inositol 1,4,5 trisphosphate 43.8 3
dopamine 14.6 3
genes like me logo Genes that share compounds with NCS1: view

Transcripts for NCS1 Gene

mRNA/cDNA for NCS1 Gene

Unigene Clusters for NCS1 Gene

Neuronal calcium sensor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCS1 Gene

No ASD Table

Relevant External Links for NCS1 Gene

GeneLoc Exon Structure for
NCS1
ECgene alternative splicing isoforms for
NCS1

Expression for NCS1 Gene

mRNA expression in normal human tissues for NCS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCS1 Gene

This gene is overexpressed in Brain - Amygdala (5.3), Brain - Hippocampus (5.2), Brain - Cortex (5.0), Brain - Anterior cingulate cortex (BA24) (4.8), and Brain - Frontal Cortex (BA9) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCS1 Gene

SOURCE GeneReport for Unigene cluster for NCS1 Gene Hs.642946

genes like me logo Genes that share expressions with NCS1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NCS1 Gene

Orthologs for NCS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCS1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCS1 35
  • 88.21 (n)
  • 94.48 (a)
NCS1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCS1 35
  • 91.25 (n)
  • 100 (a)
NCS1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncs1 35
  • 90.35 (n)
  • 100 (a)
Ncs1 16
Ncs1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCS1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCS1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncs1 35
  • 89.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves NCS1 35
  • 88.6 (n)
  • 100 (a)
NCS1 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8594 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75953 35
ncs1 35
  • 83.68 (n)
  • 99.47 (a)
zebrafish
(Danio rerio)
Actinopterygii ncs1b 35
  • 82.81 (n)
  • 97.89 (a)
ncs1b 36
  • 98 (a)
OneToOne
zgc63620 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013126 35
  • 62.65 (n)
  • 73.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Frq1 36
  • 72 (a)
OneToMany
Frq2 35
  • 67.93 (n)
  • 71.74 (a)
Frq2 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ncs-1 35
  • 66.67 (n)
  • 75.66 (a)
ncs-1 36
  • 75 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL163W 35
  • 63.51 (n)
  • 61.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRQ1 35
  • 57.54 (n)
  • 60 (a)
FRQ1 36
  • 60 (a)
OneToMany
FRQ1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02399g 35
  • 56.14 (n)
  • 59.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04379 35
  • 64.21 (n)
  • 65.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ncs1 35
  • 60.53 (n)
  • 69.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15607 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2434 36
  • 68 (a)
OneToOne
Species with no ortholog for NCS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCS1 Gene

ENSEMBL:
Gene Tree for NCS1 (if available)
TreeFam:
Gene Tree for NCS1 (if available)

Paralogs for NCS1 Gene

Selected SIMAP similar genes for NCS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCS1: view

Variants for NCS1 Gene

Sequence variations from dbSNP and Humsavar for NCS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13710 -- 130,235,496(+) GTGTC(C/T)GGCCT utr-variant-3-prime
rs709611 -- 130,236,080(+) ATCTC(C/T)TCCCC utr-variant-3-prime
rs740917 -- 130,192,323(+) CTGCC(A/G)CCCTT intron-variant
rs740918 -- 130,192,893(-) CCGCA(C/T)ACTGG intron-variant
rs740919 -- 130,192,972(-) ACCGG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCS1 Gene

Variant ID Type Subtype PubMed ID
nsv831733 CNV Loss 17160897
nsv466590 CNV Gain 19166990
nsv6732 CNV Loss 18451855
nsv520802 CNV Gain+Loss 19592680
nsv893932 CNV Loss 21882294
nsv893933 CNV Gain 21882294
nsv893934 CNV Loss 21882294
nsv893935 CNV Loss 21882294
nsv466592 CNV Loss 19166990
dgv8300n71 CNV Loss 21882294
nsv466593 CNV Loss 19166990
dgv8301n71 CNV Loss 21882294
nsv893940 CNV Gain 21882294
nsv466595 CNV Gain 19166990

Relevant External Links for NCS1 Gene

HapMap Linkage Disequilibrium report
NCS1
Human Gene Mutation Database (HGMD)
NCS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCS1 Gene

Disorders for NCS1 Gene

(1) University of Copenhagen DISEASES for NCS1 Gene

(3) Novoseek inferred disease relationships for NCS1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 28.2 8
mental retardation 21.1 1
shock 0 1

Relevant External Links for NCS1

Genetic Association Database (GAD)
NCS1
Human Genome Epidemiology (HuGE) Navigator
NCS1
genes like me logo Genes that share disorders with NCS1: view

No data available for UniProtKB/Swiss-Prot for NCS1 Gene

Publications for NCS1 Gene

  1. Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). (PMID: 11092894) Bourne Y. … Pongs O. (J. Biol. Chem. 2001) 2 3 4 23
  2. A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. (PMID: 11606724) Nakamura T.Y. … Coetzee W.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. (PMID: 12783849) Bahi N. … Chelly J. (Hum. Mol. Genet. 2003) 3 4 23
  4. Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. (PMID: 12928444) Ren X. … Takimoto K. (J. Biol. Chem. 2003) 3 23
  5. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. (PMID: 12351722) Kabbani N. … Levenson R. (J. Neurosci. 2002) 3 23

Products for NCS1 Gene

Sources for NCS1 Gene

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