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Aliases for NCR3LG1 Gene

Aliases for NCR3LG1 Gene

  • Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 2 3
  • B7 Homolog 6 2 3 4
  • B7H6 3 4 6
  • B7-H6 3 4
  • Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I21167 3
  • Natural Cytotoxicity Triggering Receptor 3 Ligand 1 3
  • DKFZp686O24166 3

External Ids for NCR3LG1 Gene

Previous GeneCards Identifiers for NCR3LG1 Gene

  • GC11P017374

Summaries for NCR3LG1 Gene

Entrez Gene Summary for NCR3LG1 Gene

  • B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

GeneCards Summary for NCR3LG1 Gene

NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for NCR3LG1 Gene

  • Triggers NCR3-dependent natural killer cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR3LG1 Gene

Genomics for NCR3LG1 Gene

Genomic Location for NCR3LG1 Gene

17,351,726 bp from pter
17,377,341 bp from pter
25,616 bases
Plus strand

Genomic View for NCR3LG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCR3LG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR3LG1 Gene

No data available for Regulatory Elements for NCR3LG1 Gene

Proteins for NCR3LG1 Gene

  • Protein details for NCR3LG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natural cytotoxicity triggering receptor 3 ligand 1
    Protein Accession:
    Secondary Accessions:
    • Q7Z3M6

    Protein attributes for NCR3LG1 Gene

    454 amino acids
    Molecular mass:
    50827 Da
    Quaternary structure:
    • Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1.
    • Sequence=CAD97811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCR3LG1 Gene

neXtProt entry for NCR3LG1 Gene

Proteomics data for NCR3LG1 Gene at MOPED

Post-translational modifications for NCR3LG1 Gene

  • Glycosylation at Asn43, Asn57, Asn174, Asn208, Asn216, Asn242, and Asn260
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR3LG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCR3LG1 Gene

Domains for NCR3LG1 Gene

Gene Families for NCR3LG1 Gene

  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • ENDOLIG :Endogenous ligands

Graphical View of Domain Structure for InterPro Entry



  • Q68D85
  • The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with NCR3LG1: view

No data available for Suggested Antigen Peptide Sequences for NCR3LG1 Gene

Function for NCR3LG1 Gene

Molecular function for NCR3LG1 Gene

UniProtKB/Swiss-Prot Function:
Triggers NCR3-dependent natural killer cell activation.

Gene Ontology (GO) - Molecular Function for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NCR3LG1: view

Phenotypes for NCR3LG1 Gene

genes like me logo Genes that share phenotypes with NCR3LG1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR3LG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCR3LG1 Gene

Localization for NCR3LG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3LG1 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019028 viral capsid IEA --
genes like me logo Genes that share ontologies with NCR3LG1: view

No data available for Subcellular locations from COMPARTMENTS for NCR3LG1 Gene

Pathways for NCR3LG1 Gene

SuperPathways for NCR3LG1 Gene

No Data Available

Interacting Proteins for NCR3LG1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000341637 Q68D85-NR3L1_HUMAN for NCR3LG1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCR3LG1 Gene


No data available for Pathways by source for NCR3LG1 Gene

Transcripts for NCR3LG1 Gene

mRNA/cDNA for NCR3LG1 Gene

(5) Additional mRNA sequences :
(8) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR3LG1 Gene

Natural killer cell cytotoxicity receptor 3 ligand 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR3LG1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3LG1 Gene

No ASD Table

Relevant External Links for NCR3LG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCR3LG1 Gene

mRNA expression in normal human tissues for NCR3LG1 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3LG1 Gene

This gene is overexpressed in Brain - Cerebellum (5.5) and Brain - Cerebellar Hemisphere (5.3).

Protein differential expression in normal tissues for NCR3LG1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCR3LG1 Gene

SOURCE GeneReport for Unigene cluster for NCR3LG1 Gene Hs.146274

mRNA Expression by UniProt/SwissProt for NCR3LG1 Gene

Tissue specificity: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).
genes like me logo Genes that share expressions with NCR3LG1: view

Expression partners for NCR3LG1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCR3LG1 Gene

Orthologs for NCR3LG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR3LG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCR3LG1 35
  • 99.2 (n)
  • 98.29 (a)
NCR3LG1 36
  • 98 (a)
(Canis familiaris)
Mammalia NCR3LG1 36
  • 44 (a)
(Anolis carolinensis)
Reptilia NCR3LG1 36
  • 30 (a)
Species with no ortholog for NCR3LG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3LG1 Gene

Gene Tree for NCR3LG1 (if available)
Gene Tree for NCR3LG1 (if available)

Paralogs for NCR3LG1 Gene

Selected SIMAP similar genes for NCR3LG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCR3LG1: view

No data available for Paralogs for NCR3LG1 Gene

Variants for NCR3LG1 Gene

Sequence variations from dbSNP and Humsavar for NCR3LG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1137707 -- 17,377,224(+) ctgta(A/G)tccca utr-variant-3-prime
rs1989133 -- 17,355,392(-) agaga(C/T)agggt intron-variant
rs2018218 -- 17,369,308(-) AGCAG(C/T)CCACA intron-variant
rs2051772 -- 17,368,303(-) ACCCA(C/T)ACCCA intron-variant
rs2079042 -- 17,365,856(-) ACTCC(A/G)ACAAA intron-variant

Relevant External Links for NCR3LG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NCR3LG1 Gene

Disorders for NCR3LG1 Gene

No disorders were found for NCR3LG1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NCR3LG1 Gene

Publications for NCR3LG1 Gene

  1. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. (PMID: 19528259) Brandt C.S. … Levin S.D. (J. Exp. Med. 2009) 2 3 4
  2. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PMID: 21422170) Li Y. … Mariuzza R.A. (J. Exp. Med. 2011) 3 4
  3. Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. (PMID: 21444796) Joyce M.G. … Sun P.D. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3
  4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PMID: 21875946) Berndt J.D. … Moon R.T. (J. Cell Biol. 2011) 3
  5. B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. (PMID: 21877119) Kaifu T. … Baratin M. (Cell. Mol. Life Sci. 2011) 3

Products for NCR3LG1 Gene

Sources for NCR3LG1 Gene

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