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NCR3LG1 Gene

protein-coding   GIFtS: 41
GCID: GC11P017374

Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1

  Search for NCR3LG1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 11 2     DKFZp686O241662
B7 Homolog 61 2 3     Natural Cytotoxicity Triggering Receptor 3 Ligand 12
B7H62 3 5     Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I211672
B7-H62 3     

External Ids:    HGNC: 424001   Entrez Gene: 3743832   Ensembl: ENSG000001882117   OMIM: 6137145   UniProtKB: Q68D853   

Export aliases for NCR3LG1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCR3LG1 Gene:
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6
with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al.,
2009 (PubMed 19528259)).(supplied by OMIM, Jan 2011)

GeneCards Summary for NCR3LG1 Gene:
NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1) is a protein-coding gene. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85
Function: Triggers NCR3-dependent natural killer cell activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NCR3LG1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NCR3LG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCR3LG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

NCR3LG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCR3LG1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P017374:  view genomic region     (about GC identifiers)

Start:
17,373,273 bp from pter      End:
17,398,888 bp from pter
Size:
25,616 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85 (See protein sequence)
Recommended Name: Natural cytotoxicity triggering receptor 3 ligand 1 precursor  
Size: 454 amino acids; 50827 Da
Subunit: Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors,
including NCR1, NCR2 and KLRK1
Sequence caution: Sequence=CAD97811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NCR3LG1:
3PV6 (3D)        3PV7 (3D)    
Secondary accessions: Q7Z3M6

Explore the universe of human proteins at neXtProt for NCR3LG1: NX_Q68D85

Explore proteomics data for NCR3LG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43, Asn57, Asn174, Asn208, Asn216, Asn242, Asn260

  • See NCR3LG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001189368.1  
    ENSEMBL proteins: 
     ENSP00000341637   ENSP00000434394  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR000840 G_retro_matrix_N

    Graphical View of Domain Structure for InterPro Entry Q68D85

    ProtoNet protein and cluster: Q68D85

    2 Blocks protein domains:
    IPB000840 Matrix protein (MA)
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85
    Domain: The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of
    a fusion between an Ig-like domain-containing protein and a ERV
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with NCR3LG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR3L1_HUMAN, Q68D85
    Function: Triggers NCR3-dependent natural killer cell activation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NCR3LG1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NCR3LG1:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCR3LG1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR3L1_HUMAN, Q68D85: Cell membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0019028viral capsid IEA--

    Find genes that share ontologies with NCR3LG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCR3LG1
    Interactions:

        Search GeneGlobe Interaction Network for NCR3LG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCR3LG1 (Q68D853 ENSP000003416374) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    ENSG00000206430ENSP000003729694STRING: ENSP00000372969
    PVRL4ENSP000003569914STRING: ENSP00000356991
    MDGA2ENSP000003821784STRING: ENSP00000382178
    IGHEENSP000003749834STRING: ENSP00000374983
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCR3LG1 (NR3L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCR3LG1 gene (2 alternative transcripts): 
    NM_001009913.1  NM_001202439.2  

    Unigene Cluster for NCR3LG1:

    Natural killer cell cytotoxicity receptor 3 ligand 1
    Hs.146274  [show with all ESTs]
    Unigene Representative Sequence: BX537685
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338965(uc001mmz.4) ENST00000530403
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    Additional mRNA sequence: 

    AK123657.1 BC136797.1 BC136800.1 BX537685.1 CR749521.1 

    4 DOTS entries:

    DT.70102431  DT.101974002  DT.120721412  DT.435660 

    1 AceView cDNA sequence:

    BF591068 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCR3LG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCR3LG1 Expression
    About this image

    NCR3LG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCR3LG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146274

    UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85
    Tissue specificity: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines
    including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells
    (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCR3LG1 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia NCR3LG16
    natural killer cell cytotoxicity receptor 3 ligand...
    44(a)
    1 ↔ 1
    21(39928438-39950067)
    lizard
    (Anolis carolinensis)
    Reptilia NCR3LG16
    natural killer cell cytotoxicity receptor 3 ligand...
    30(a)
    1 ↔ 1
    4(144653952-144669568)


    ENSEMBL Gene Tree for NCR3LG1 (if available)
    TreeFam Gene Tree for NCR3LG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCR3LG1 gene
    1 SIMAP similar gene for NCR3LG1 using alignment to 1 protein entry:     NR3L1_HUMAN:
    PLAC4

    Find genes that share paralogs with NCR3LG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCR3LG1 (see all 515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901646271,2
    --17371488(+) GTGCAC/TCAATA 1 -- us2k10--------
    rs1508475361,2
    --17371503(+) ACACAC/GAAAGT 1 -- us2k10--------
    rs1920447351,2
    --17371644(+) GTGTGA/GTGGCT 1 -- us2k10--------
    rs108327731,2
    C,F,A--17371784(+) GTGGCG/AGGCAC 1 -- us2k14Minor allele frequency- A:0.33NA CSA 6
    rs108327741,2
    C,F,A--17371793(+) ACCTGT/CAATCC 1 -- us2k14Minor allele frequency- C:0.33NA CSA 6
    rs1442169851,2
    C--17371795(+) CTGCAA/GTCCCA 1 -- us2k10--------
    rs64863631,2
    C,F,A--17371802(+) CCCAGT/CTACTT 1 -- us2k14Minor allele frequency- C:0.43NA WA CSA 7
    rs1841040381,2
    --17371834(+) AATAAG/TCTCTT 1 -- us2k10--------
    rs1886437521,2
    --17371848(+) CCTGGA/GAGGCA 1 -- us2k10--------
    rs1468928601,2
    --17372137(+) GATGTA/GTATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCR3LG1 (17373273 - 17398888 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NCR3LG1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCR3LG1
    DNA2.0 Custom Variant and Variant Library Synthesis for NCR3LG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613714    OMIM disorders: --


    Find genes that share disorders with NCR3LG1           About GenesLikeMe


    Export disorders for NCR3LG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCR3LG1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with NCR3LG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. (PubMed id 19528259)1, 2, 3 Brandt C.S.... Levin S.D. (J. Exp. Med. 2009)
    2. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PubMed id 21422170)1, 2 Li Y.... Mariuzza R.A. (J. Exp. Med. 2011)
    3. Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. (PubMed id 23687088)1 Matta J....Vivier E. (Blood 2013)
    4. Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity. (PubMed id 23066150)1 Kellner C....Peipp M. (J. Immunol. 2012)
    5. Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. (PubMed id 21444796)1 Joyce M.G.... Sun P.D. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    6. B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. (PubMed id 21877119)1 Kaifu T....Baratin M. (Cell. Mol. Life Sci. 2011)
    7. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (J. Cell Biol. 2011)
    8. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374383 HGNC: 42400 AceView: DKFZp686O24166.1 Ensembl:ENSG00000188211 euGenes: HUgn374383
    ECgene: NCR3LG1 H-InvDB: NCR3LG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCR3LG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCR3LG1 gene:
    Search GeneIP for patents involving NCR3LG1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NCR3LG1
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     Search Addgene for plasmids for NCR3LG1
      Search eBioscience for proteins for NCR3LG1
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      eBioscience FlowRNA Probe Sets
           
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