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Aliases for NCR3LG1 Gene

Aliases for NCR3LG1 Gene

  • Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 2 3 5
  • B7 Homolog 6 2 3 4
  • B7-H6 3 4
  • B7H6 3 4
  • Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I21167 3
  • Natural Cytotoxicity Triggering Receptor 3 Ligand 1 3
  • DKFZp686O24166 3

External Ids for NCR3LG1 Gene

Previous GeneCards Identifiers for NCR3LG1 Gene

  • GC11P017374

Summaries for NCR3LG1 Gene

Entrez Gene Summary for NCR3LG1 Gene

  • B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

GeneCards Summary for NCR3LG1 Gene

NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for NCR3LG1 Gene

  • Triggers NCR3-dependent natural killer cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR3LG1 Gene

Genomics for NCR3LG1 Gene

Regulatory Elements for NCR3LG1 Gene

Enhancers for NCR3LG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F017351 0.9 FANTOM5 ENCODE 54.9 +1.3 1299 3.5 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 KLF13 SP3 SP5 NCR3LG1 KCNJ11 RPS13 LOC105376576 PIR55310
GH11F017313 1 FANTOM5 ENCODE 34.3 -37.6 -37615 2.0 PKNOX1 INSM2 ZEB1 ZNF324 ZNF316 ZNF366 ZNF600 BHLHE40 GFI1B SP2 NCR3LG1 RPS13 SNORD14B LOC105376575 GC11M017256
GH11F017383 1.1 Ensembl ENCODE 27.6 +32.3 32292 0.8 HDAC1 CTCF ZNF2 RAD21 YY1 ZNF316 ZNF766 POLR2A ZBTB48 ZNF143 NCR3LG1 KCNJ11 ENSG00000260196 GC11M017380 GC11P017387
GH11F017381 0.7 ENCODE 26.1 +29.8 29750 0.9 RFX1 NCR3LG1 ENSG00000260196 GC11M017380
GH11F017401 0.2 ENCODE 19.9 +49.6 49584 0.4 NCR3LG1 ABCC8 GC11P017401 GC11P017408
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NCR3LG1 on UCSC Golden Path with GeneCards custom track

Promoters for NCR3LG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001568622 1274 3601 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 KLF13 SP3 SP5

Genomic Location for NCR3LG1 Gene

Chromosome:
11
Start:
17,351,726 bp from pter
End:
17,381,661 bp from pter
Size:
29,936 bases
Orientation:
Plus strand

Genomic View for NCR3LG1 Gene

Genes around NCR3LG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR3LG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR3LG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR3LG1 Gene

Proteins for NCR3LG1 Gene

  • Protein details for NCR3LG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D85-NR3L1_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3 ligand 1
    Protein Accession:
    Q68D85
    Secondary Accessions:
    • Q7Z3M6

    Protein attributes for NCR3LG1 Gene

    Size:
    454 amino acids
    Molecular mass:
    50827 Da
    Quaternary structure:
    • Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1.
    SequenceCaution:
    • Sequence=CAD97811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCR3LG1 Gene

neXtProt entry for NCR3LG1 Gene

Post-translational modifications for NCR3LG1 Gene

  • Glycosylation at Asn 43, Asn 57, Asn 174, Asn 208, Asn 216, Asn 242, and Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR3LG1 Gene

No data available for DME Specific Peptides for NCR3LG1 Gene

Domains & Families for NCR3LG1 Gene

Gene Families for NCR3LG1 Gene

Suggested Antigen Peptide Sequences for NCR3LG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68D85

UniProtKB/Swiss-Prot:

NR3L1_HUMAN :
  • The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
Domain:
  • The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with NCR3LG1: view

Function for NCR3LG1 Gene

Molecular function for NCR3LG1 Gene

UniProtKB/Swiss-Prot Function:
Triggers NCR3-dependent natural killer cell activation.

Gene Ontology (GO) - Molecular Function for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with NCR3LG1: view

Phenotypes for NCR3LG1 Gene

genes like me logo Genes that share phenotypes with NCR3LG1: view

Animal Model Products

miRNA for NCR3LG1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCR3LG1 Gene

Localization for NCR3LG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3LG1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR3LG1 Gene COMPARTMENTS Subcellular localization image for NCR3LG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019028 viral capsid IEA --
genes like me logo Genes that share ontologies with NCR3LG1: view

Pathways & Interactions for NCR3LG1 Gene

genes like me logo Genes that share pathways with NCR3LG1: view

Interacting Proteins for NCR3LG1 Gene

Gene Ontology (GO) - Biological Process for NCR3LG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR3LG1: view

No data available for SIGNOR curated interactions for NCR3LG1 Gene

Transcripts for NCR3LG1 Gene

mRNA/cDNA for NCR3LG1 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR3LG1 Gene

Natural killer cell cytotoxicity receptor 3 ligand 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3LG1 Gene

No ASD Table

Relevant External Links for NCR3LG1 Gene

GeneLoc Exon Structure for
NCR3LG1
ECgene alternative splicing isoforms for
NCR3LG1

Expression for NCR3LG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCR3LG1 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3LG1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for NCR3LG1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCR3LG1 Gene



Protein tissue co-expression partners for NCR3LG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCR3LG1 Gene:

NCR3LG1

SOURCE GeneReport for Unigene cluster for NCR3LG1 Gene:

Hs.146274

mRNA Expression by UniProt/SwissProt for NCR3LG1 Gene:

Q68D85-NR3L1_HUMAN
Tissue specificity: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).
genes like me logo Genes that share expression patterns with NCR3LG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCR3LG1 Gene

Orthologs for NCR3LG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR3LG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR3LG1 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia NCR3LG1 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCR3LG1 35
  • 30 (a)
OneToOne
Species where no ortholog for NCR3LG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3LG1 Gene

ENSEMBL:
Gene Tree for NCR3LG1 (if available)
TreeFam:
Gene Tree for NCR3LG1 (if available)

Paralogs for NCR3LG1 Gene

(1) SIMAP similar genes for NCR3LG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCR3LG1: view

No data available for Paralogs for NCR3LG1 Gene

Variants for NCR3LG1 Gene

Sequence variations from dbSNP and Humsavar for NCR3LG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10535629 -- 17,353,714(+) CGGCA(-/GCA)GCAGC intron-variant, upstream-variant-2KB, cds-indel
rs10766389 -- 17,359,015(+) CACTA(A/T)AAGAT intron-variant
rs10766390 -- 17,365,402(+) TGTTG(G/T)AGGAG intron-variant
rs10766391 -- 17,371,721(+) CTCCC(A/G)TGGTT intron-variant
rs10832773 -- 17,350,237(+) GTGGC(A/G)GGCAC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCR3LG1 Gene

Variant ID Type Subtype PubMed ID
nsv467712 CNV loss 19166990
nsv469895 CNV loss 16826518
nsv553567 CNV gain 21841781
nsv553583 CNV loss 21841781

Variation tolerance for NCR3LG1 Gene

Gene Damage Index Score: 4.24; 62.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR3LG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR3LG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR3LG1 Gene

Disorders for NCR3LG1 Gene

Relevant External Links for NCR3LG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR3LG1

No disorders were found for NCR3LG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCR3LG1 Gene

Publications for NCR3LG1 Gene

  1. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. (PMID: 19528259) Brandt C.S. … Levin S.D. (J. Exp. Med. 2009) 2 3 4 64
  2. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PMID: 21422170) Li Y. … Mariuzza R.A. (J. Exp. Med. 2011) 3 4 64
  3. Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production. (PMID: 26582946) Salimi M. … Ogg G.S. (J. Immunol. 2016) 3 64
  4. Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients. (PMID: 25877893) Semeraro M. … Zitvogel L. (Sci Transl Med 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NCR3LG1 Gene

Sources for NCR3LG1 Gene

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