NCR3LG1 Gene
protein-coding GIFtS: 39
GCID: GC11P017374
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natural killer cell cytotoxicity receptor 3 ligand 1
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Aliases
for NCR3LG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Natural Killer Cell Cytotoxicity Receptor 3 Ligand 11 2 | | B7 Homolog 62 3 | | B7-H61 2 3 | | Natural Cytotoxicity Triggering Receptor 3 Ligand 12 | | B7H62 3 5 | | Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I211672 | | DKFZp686O241661 2 | | |
Export aliases for NCR3LG1 gene to outside databases |
Summaries
for NCR3LG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCR3LG1:
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 withNKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 (PubMed19528259)).(supplied by OMIM, Jan 2011)
UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85Function: Triggers NCR3-dependent natural killer cell activation
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Genomic Views
for NCR3LG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NCR3LG1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCR3LG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCR3LG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1NCR3LG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P017374: view genomic region
(about GC identifiers)
Start:
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17,373,273 bp from pter |
End:
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17,398,888 bp from pter |
Size:
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25,616 bases |
Orientation:
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plus strand |
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Proteins
for NCR3LG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85 (See
protein sequence)Recommended Name: Natural cytotoxicity triggering receptor 3 ligand 1 precursor Size: 454 amino acids; 50827 Da
Subunit: Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors,including NCR1, NCR2 and KLRK1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAD97811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for NCR3LG1:3PV6 (3D)
3PV7 (3D)
Secondary accessions: Q7Z3M6Explore the universe of human proteins at neXtProt for NCR3LG1: NX_Q68D85
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68D85
NCR3LG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001189368.1
ENSEMBL proteins: ENSP00000341637 ENSP00000434394
Human Recombinant Protein Products for NCR3LG1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NCR3LG1 for ontologies About GeneDecksing
NCR3LG1 Antibody Products:
Assay Products for NCR3LG1: |
Protein
Domains /
Families
for NCR3LG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCR3LG1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q68D85ProtoNet protein and cluster: Q68D85 2 Blocks protein families: IPB000840 Matrix protein (MA) IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85Domain: The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of afusion between an Ig-like domain-containing protein and a ERVSimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for NCR3LG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NR3L1_HUMAN, Q68D85Function: Triggers NCR3-dependent natural killer cell activation Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
NCR3LG1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for NCR3LG1:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR3LG1 |
|
Pathways & Interactions
for NCR3LG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCR3LG1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for NCR3LG1 (Q68D853 ENSP000003416374) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for NCR3LG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NCR3LG1
Search CenterWatch for drugs/clinical trials and news about NCR3LG1 / NR3L1 
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Transcripts
for NCR3LG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCR3LG1 gene (2 alternative transcripts): NM_001009913.1 NM_001202439.1 Unigene Cluster for NCR3LG1: Natural killer cell cytotoxicity receptor 3 ligand 1 Hs.146274 [show with all ESTs]Unigene Representative Sequence: BX5376852 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338965(uc001mmz.4) ENST00000530403
Additional cDNA sequence: AK123657.1 BC136797.1 BC136800.1 BX537685.1 CR749521.1 4 DOTS entries: DT.70102431 DT.101974002 DT.120721412 DT.435660 1 AceView cDNA sequence: BF591068
GeneLoc Exon Structure
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Expression
for NCR3LG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See NCR3LG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCR3LG1
SOURCE GeneReport for Unigene cluster: Hs.146274
UniProtKB/Swiss-Prot: NR3L1_HUMAN, Q68D85Tissue specificity: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell linesincluding T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (atprotein level)
SABiosciences Custom PCR Arrays for NCR3LG1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCR3LG1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NCR3LG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCR3LG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR3LG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR3LG1 |
Orthologs
for NCR3LG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NCR3LG1 gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
NCR3LG16 |
-- |
30(a) |
1 ↔ 1 |
4(144663508-144664580) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1982416dhrs13b6 |
dehydrogenase/reductase (SDR family) member 13b |
12(a)11(a) |
1 ↔ many1 ↔ many |
15(23942545-23950532) 15(23917052-23935907) |
ENSEMBL Gene Tree for NCR3LG1 (if available)
TreeFam Gene Tree for NCR3LG1 (if available) |
Paralogs
for NCR3LG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NCR3LG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCR3LG1 (17373273 - 17398888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NCR3LG1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCR3LG1 |
|
Disorders
/ Diseases
for NCR3LG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCR3LG1 for disorders About GeneDecksing
OMIM gene information: 613714
OMIM disorders: --
4  diseases for NCR3LG1: About MalaCardsmyeloid leukemia melanoma leukemia carcinoma
Export disorders for NCR3LG1 gene to outside databases
|
Publications
for NCR3LG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCR3LG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NCR3LG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. (PubMed id 19528259)1, 2, 3 Brandt C.S....Levin S.D. (2009)
- Structure of the human activating natural cytotoxicit y receptor NKp30 bound to its tumor cell ligand B7-H6. (PubMed id 21422170)1, 2 Li Y....Mariuzza R.A. (2011)
- Mimicking an induced self phenotype by coating lymphom as with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity. (PubMed id 23066150)1 Kellner C....Peipp M. (2012)
- Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
- Crystal structure of human natural cytotoxicity recep tor NKp30 and identification of its ligand binding site. (PubMed id 21444796)1 Joyce M.G....Sun P.D. (2011)
- B7-H6/NKp30 interaction: a mechanism of alerting NK ce lls against tumors. (PubMed id 21877119)1 Kaifu T....Baratin M. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NCR3LG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NCR3LG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCR3LG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCR3LG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NCR3LG1 gene:
Search GeneIP for patents involving NCR3LG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCR3LG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCR3LG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCR3LG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCR3LG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCR3LG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR3LG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCR3LG1 |
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| | | | Search Tocris compounds for NCR3LG1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR3LG1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NCR3LG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCR3LG1 |
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