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Aliases for NCR3 Gene

Aliases for NCR3 Gene

  • Natural Cytotoxicity Triggering Receptor 3 2 3 5
  • Natural Killer Cell P30-Related Protein 3 4
  • Activating Natural Killer Receptor P30 3 4
  • Lymphocyte Antigen 117 2 3
  • NK-P30 3 4
  • LY117 3 4
  • NKp30 3 4
  • 1C7 3 4
  • Activating NK-A1 Receptor 3
  • CD337 Antigen 4
  • CD337 3
  • MALS 3

External Ids for NCR3 Gene

Previous HGNC Symbols for NCR3 Gene

  • LY117

Previous GeneCards Identifiers for NCR3 Gene

  • GC06M031610
  • GC06M031327
  • GC06M031660
  • GC06M031664
  • GC06M031557
  • GC06M031343
  • GC06M031558
  • GC06M031575
  • GC06M031677

Summaries for NCR3 Gene

Entrez Gene Summary for NCR3 Gene

  • The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for NCR3 Gene

NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include Malaria, Mild and Chronic Intestinal Vascular Insufficiency. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions.

UniProtKB/Swiss-Prot for NCR3 Gene

  • Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Gene Wiki entry for NCR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR3 Gene

Genomics for NCR3 Gene

Regulatory Elements for NCR3 Gene

Enhancers for NCR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031557 1.3 Ensembl ENCODE 13.2 +33.4 33429 4.2 HDGF PKNOX1 AGO1 WRNIP1 ZNF2 ZNF143 ZNF207 FOS KLF13 ZNF263 CSNK2B DDX39B LST1 NCR3 UQCRHP1 LTB AIF1 SNORD117 PSORS1C2 C6orf47
GH06G031269 1.6 FANTOM5 ENCODE dbSUPER 2.2 +321.6 321558 4.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 HLA-C PSORS1C3 PPT2 DDX39B LY6G5B TCF19 LSM2 PSORS1C2 ATF6B HCG18
GH06G031591 1.2 Ensembl ENCODE 0.7 -0.1 -63 2.3 HDGF TCF12 GATA2 ELK1 ZNF143 FOS KLF13 PAF1 ZNF263 MCM3 DDX39B ATP6V1G2 LOC101929072 ENSG00000271581 LST1 MICB HLA-C SKIV2L NCR3 UQCRHP1
GH06G031596 1 Ensembl ENCODE 0.7 -4.2 -4161 0.5 HDAC1 CTCF PKNOX1 ATF1 SAP130 ARNT ZMYM3 MAX ZNF2 RAD21 DDX39B LST1 MICB NCR3 UQCRHP1
GH06G031598 1.2 Ensembl ENCODE 0.4 -5.4 -5414 0.3 ARNT ZNF2 YY1 GLIS2 ZNF263 SP3 YY2 REST MIER2 ZNF592 MICB C4A NCR3 UQCRHP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCR3 Gene

Chromosome:
6
Start:
31,588,883 bp from pter
End:
31,593,019 bp from pter
Size:
4,137 bases
Orientation:
Minus strand

Genomic View for NCR3 Gene

Genes around NCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR3 Gene

  • Protein details for NCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14931-NCTR3_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3
    Protein Accession:
    O14931
    Secondary Accessions:
    • B0S8F2
    • B0S8F4
    • B0S8F5
    • O14930
    • O14932
    • O95667
    • O95668
    • O95669
    • Q5ST89
    • Q5ST90
    • Q5ST91
    • Q5ST92
    • Q5STA3

    Protein attributes for NCR3 Gene

    Size:
    201 amino acids
    Molecular mass:
    21593 Da
    Quaternary structure:
    • Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

    Three dimensional structures from OCA and Proteopedia for NCR3 Gene

    Alternative splice isoforms for NCR3 Gene

neXtProt entry for NCR3 Gene

Post-translational modifications for NCR3 Gene

  • Glycosylation at posLast=4242 and Asn121

Antibody Products

  • Abcam antibodies for NCR3

No data available for DME Specific Peptides for NCR3 Gene

Domains & Families for NCR3 Gene

Gene Families for NCR3 Gene

Protein Domains for NCR3 Gene

Suggested Antigen Peptide Sequences for NCR3 Gene

Graphical View of Domain Structure for InterPro Entry

O14931

UniProtKB/Swiss-Prot:

NCTR3_HUMAN :
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR3: view

Function for NCR3 Gene

Molecular function for NCR3 Gene

UniProtKB/Swiss-Prot Function:
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Gene Ontology (GO) - Molecular Function for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 18852879
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with NCR3: view
genes like me logo Genes that share phenotypes with NCR3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NCR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR3 Gene

Localization for NCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7590964
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCR3: view

Pathways & Interactions for NCR3 Gene

genes like me logo Genes that share pathways with NCR3: view

Gene Ontology (GO) - Biological Process for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002429 immune response-activating cell surface receptor signaling pathway IDA 18852879
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA --
GO:0006954 inflammatory response NAS 10941844
GO:0006955 immune response NAS 10941844
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
genes like me logo Genes that share ontologies with NCR3: view

No data available for SIGNOR curated interactions for NCR3 Gene

Drugs & Compounds for NCR3 Gene

No Compound Related Data Available

Transcripts for NCR3 Gene

mRNA/cDNA for NCR3 Gene

Unigene Clusters for NCR3 Gene

Natural cytotoxicity triggering receptor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NCR3

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3 Gene

No ASD Table

Relevant External Links for NCR3 Gene

GeneLoc Exon Structure for
NCR3
ECgene alternative splicing isoforms for
NCR3

Expression for NCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCR3 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3 Gene

This gene is overexpressed in Whole Blood (x29.7) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for NCR3 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCR3 Gene



Protein tissue co-expression partners for NCR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCR3 Gene:

NCR3

SOURCE GeneReport for Unigene cluster for NCR3 Gene:

Hs.509513

mRNA Expression by UniProt/SwissProt for NCR3 Gene:

O14931-NCTR3_HUMAN
Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

Evidence on tissue expression from TISSUES for NCR3 Gene

  • Blood(4.5)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with NCR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR3 Gene

Orthologs for NCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR3 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia NCR3 34 35
  • 84.02 (n)
dog
(Canis familiaris)
Mammalia NCR3 34 35
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Ncr3 34
  • 78.64 (n)
Species where no ortholog for NCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3 Gene

ENSEMBL:
Gene Tree for NCR3 (if available)
TreeFam:
Gene Tree for NCR3 (if available)

Paralogs for NCR3 Gene

No data available for Paralogs for NCR3 Gene

Variants for NCR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NCR3 Gene

NCTR3_HUMAN-O14931
A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148].

Sequence variations from dbSNP and Humsavar for NCR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2736191 other 31,593,133(-) TCCTG(C/G)AGGCT upstream-variant-2KB
rs1000228388 -- 31,588,957(+) CAGGG(A/G)CCCAA downstream-variant-500B, utr-variant-3-prime
rs1000229937 -- 31,591,538(+) CGGCC(A/G)GGTGC intron-variant
rs1000578864 -- 31,591,874(+) AATTT(A/G)GGAGA intron-variant
rs1001856417 -- 31,593,251(+) GGCTA(C/T)TCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCR3 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv830627 CNV loss 17160897

Variation tolerance for NCR3 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR3 Gene

Human Gene Mutation Database (HGMD)
NCR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR3

Disorders for NCR3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NCR3 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malaria, mild
  • malaria, mild, susceptibility to
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
median arcuate ligament syndrome
  • celiac artery compression syndrome
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search NCR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCR3

Genetic Association Database (GAD)
NCR3
Human Genome Epidemiology (HuGE) Navigator
NCR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR3
genes like me logo Genes that share disorders with NCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR3 Gene

Publications for NCR3 Gene

  1. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PMID: 17208487) Delahaye N.F. … Rihet P. (Microbes Infect. 2007) 3 4 46 64
  2. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. (PMID: 11782277) Sato M. … Yabe T. (Tissue Antigens 2001) 2 3 22 64
  3. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. (PMID: 10562324) Pende D. … Moretta A. (J. Exp. Med. 1999) 3 4 22 64
  4. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PMID: 8824804) Nalabolu S.R. … Weissman S.M. (Genomics 1996) 2 3 4 64
  5. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PMID: 21422170) Li Y. … Mariuzza R.A. (J. Exp. Med. 2011) 3 4 64

Products for NCR3 Gene

Sources for NCR3 Gene

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