Aliases for NCR3 Gene
External Ids for NCR3 Gene
Previous HGNC Symbols for NCR3 Gene
Previous GeneCards Identifiers for NCR3 Gene
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
GeneCards Summary for NCR3 Gene
NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include malaria, mild and allergic contact dermatitis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells.
UniProtKB/Swiss-Prot for NCR3 Gene
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.