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Aliases for NCR3 Gene

Aliases for NCR3 Gene

  • Natural Cytotoxicity Triggering Receptor 3 2 3 5
  • Natural Killer Cell P30-Related Protein 3 4
  • Activating Natural Killer Receptor P30 3 4
  • Lymphocyte Antigen 117 2 3
  • NK-P30 3 4
  • LY117 3 4
  • NKp30 3 4
  • 1C7 3 4
  • Activating NK-A1 Receptor 3
  • CD337 Antigen 4
  • CD337 3
  • MALS 3

External Ids for NCR3 Gene

Previous HGNC Symbols for NCR3 Gene

  • LY117

Previous GeneCards Identifiers for NCR3 Gene

  • GC06M031610
  • GC06M031327
  • GC06M031660
  • GC06M031664
  • GC06M031557
  • GC06M031343
  • GC06M031558
  • GC06M031575
  • GC06M031677

Summaries for NCR3 Gene

Entrez Gene Summary for NCR3 Gene

  • The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for NCR3 Gene

NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include malaria, mild and malaria. Among its related pathways are Immune System and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers.

UniProtKB/Swiss-Prot for NCR3 Gene

  • Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Gene Wiki entry for NCR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR3 Gene

Genomics for NCR3 Gene

Regulatory Elements for NCR3 Gene

Genomic Location for NCR3 Gene

Chromosome:
6
Start:
31,588,883 bp from pter
End:
31,593,019 bp from pter
Size:
4,137 bases
Orientation:
Minus strand

Genomic View for NCR3 Gene

Genes around NCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR3 Gene

  • Protein details for NCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14931-NCTR3_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3
    Protein Accession:
    O14931
    Secondary Accessions:
    • B0S8F2
    • B0S8F4
    • B0S8F5
    • O14930
    • O14932
    • O95667
    • O95668
    • O95669
    • Q5ST89
    • Q5ST90
    • Q5ST91
    • Q5ST92
    • Q5STA3

    Protein attributes for NCR3 Gene

    Size:
    201 amino acids
    Molecular mass:
    21593 Da
    Quaternary structure:
    • Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

    Three dimensional structures from OCA and Proteopedia for NCR3 Gene

    Alternative splice isoforms for NCR3 Gene

neXtProt entry for NCR3 Gene

Proteomics data for NCR3 Gene at MOPED

Post-translational modifications for NCR3 Gene

  • Glycosylation at Asn 42 and Asn 121

Other Protein References for NCR3 Gene

Antibody Products

No data available for DME Specific Peptides for NCR3 Gene

Domains & Families for NCR3 Gene

Gene Families for NCR3 Gene

Protein Domains for NCR3 Gene

Suggested Antigen Peptide Sequences for NCR3 Gene

Graphical View of Domain Structure for InterPro Entry

O14931

UniProtKB/Swiss-Prot:

NCTR3_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR3: view

Function for NCR3 Gene

Molecular function for NCR3 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Gene Ontology (GO) - Molecular Function for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with NCR3: view
genes like me logo Genes that share phenotypes with NCR3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR3 Gene

Localization for NCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR3 Gene COMPARTMENTS Subcellular localization image for NCR3 gene
Compartment Confidence
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with NCR3: view

Pathways & Interactions for NCR3 Gene

genes like me logo Genes that share pathways with NCR3: view

Interacting Proteins for NCR3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342156%0d%0a9606.ENSP00000341637%0d%0a9606.ENSP00000354782%0d%0a9606.ENSP00000340210%0d%0a
Selected Interacting proteins: ENSP00000342156 O14931-NCTR3_HUMAN for NCR3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition TAS 16304049
genes like me logo Genes that share ontologies with NCR3: view

No data available for SIGNOR curated interactions for NCR3 Gene

Drugs & Compounds for NCR3 Gene

No Compound Related Data Available

Transcripts for NCR3 Gene

mRNA/cDNA for NCR3 Gene

Unigene Clusters for NCR3 Gene

Natural cytotoxicity triggering receptor 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3 Gene

No ASD Table

Relevant External Links for NCR3 Gene

GeneLoc Exon Structure for
NCR3
ECgene alternative splicing isoforms for
NCR3

Expression for NCR3 Gene

mRNA expression in normal human tissues for NCR3 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3 Gene

This gene is overexpressed in Whole Blood (x29.7) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for NCR3 Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCR3 Gene



SOURCE GeneReport for Unigene cluster for NCR3 Gene Hs.509513

mRNA Expression by UniProt/SwissProt for NCR3 Gene

O14931-NCTR3_HUMAN
Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
genes like me logo Genes that share expression patterns with NCR3: view

Protein tissue co-expression partners for NCR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCR3 Gene

Orthologs for NCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR3 35
  • 99.5 (n)
  • 99 (a)
NCR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCR3 36
  • 75 (a)
OneToOne
NCR3 35
  • 84.02 (n)
  • 77.78 (a)
dog
(Canis familiaris)
Mammalia NCR3 35
  • 82.22 (n)
  • 74.87 (a)
NCR3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncr3 35
  • 78.64 (n)
  • 67.66 (a)
Species with no ortholog for NCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3 Gene

ENSEMBL:
Gene Tree for NCR3 (if available)
TreeFam:
Gene Tree for NCR3 (if available)

Paralogs for NCR3 Gene

No data available for Paralogs for NCR3 Gene

Variants for NCR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NCR3 Gene

O14931-NCTR3_HUMAN
A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148].

Sequence variations from dbSNP and Humsavar for NCR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11575840 - 31,589,863(-) ATGAC(A/G)CCAGC reference, missense
VAR_044115 -
rs2736190 -- 31,593,434(-) tgggc(A/G)acaga upstream-variant-2KB
rs2736191 -- 31,593,133(-) TCCTG(C/G)AGGCT upstream-variant-2KB
rs2515920 -- 31,594,838(-) TTATT(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCR3 Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Variation tolerance for NCR3 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR3 Gene

HapMap Linkage Disequilibrium report
NCR3
Human Gene Mutation Database (HGMD)
NCR3

Disorders for NCR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NCR3 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malaria, mild
  • malaria, mild, susceptibility to
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search NCR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCR3

Genetic Association Database (GAD)
NCR3
Human Genome Epidemiology (HuGE) Navigator
NCR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR3
genes like me logo Genes that share disorders with NCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR3 Gene

Publications for NCR3 Gene

  1. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PMID: 17208487) Delahaye N.F. … Rihet P. (Microbes Infect. 2007) 3 4 48 67
  2. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. (PMID: 11782277) Sato M. … Yabe T. (Tissue Antigens 2001) 2 3 23
  3. Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30. (PMID: 19580844) Balsamo M. … Vitale M. (Exp. Hematol. 2009) 3 23
  4. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y. … Lin Q. (Fertil. Steril. 2008) 3 23
  5. Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels. (PMID: 18275895) Boyiadzis M. … Hakim F.T. (Biol. Blood Marrow Transplant. 2008) 3 23

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