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NCR3 Gene

protein-coding   GIFtS: 57
GCID: GC06M031677

Natural Cytotoxicity Triggering Receptor 3

(Previous name: lymphocyte antigen 117)
(Previous symbol: LY117)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natural Cytotoxicity Triggering Receptor 31 2     NKp302 3
LY1171 2 3     CD3372 5
1C72 3 5     MALS2 5
Lymphocyte Antigen 1171 2     Activating NK-A1 Receptor2
Activating Natural Killer Receptor P302 3     CD337 Antigen3
Natural Killer Cell P30-Related Protein2 3     NKP305
NK-p302 3     

External Ids:    HGNC: 190771   Entrez Gene: 2591972   Ensembl: ENSG000002044757   OMIM: 6115505   UniProtKB: O149313   

Export aliases for NCR3 gene to outside databases

Previous GC identifers: GC06M031610 GC06M031327 GC06M031660 GC06M031664 GC06M031557 GC06M031343 GC06M031558 GC06M031575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCR3 Gene:
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of
tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide
polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility.
Three transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, May
2010)

GeneCards Summary for NCR3 Gene:
NCR3 (natural cytotoxicity triggering receptor 3) is a protein-coding gene. Diseases associated with NCR3 include neonatal abstinence syndrome, and malaria, mild.

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural
killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC)
maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK
cells to release TNFA and IFNG, which promotes DC maturation

Gene Wiki entry for NCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_167244.2  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCR3 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCR3 promoter sequence
   Search Chromatin IP Primers for NCR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCR3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031677:  view genomic region     (about GC identifiers)

Start:
31,556,660 bp from pter      End:
31,560,762 bp from pter
Size:
4,103 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_167246 2,899,544-2,903,646      Chr6-,NT_167248 2,850,302-2,854,402      Chr6-,NT_167247 2,936,361-2,940,463     
Chr6-,NT_167244 2,871,378-2,875,480      Chr6-,NT_167245 2,842,205-2,846,307      Chr6-,NT_167249 2,887,462-2,891,563     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931 (See protein sequence)
Recommended Name: Natural cytotoxicity triggering receptor 3 precursor  
Size: 201 amino acids; 21593 Da
Subunit: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to
NCR3LG1. Interacts with and is activated by binding to BAG6
2 PDB 3D structures from and Proteopedia for NCR3:
3NOI (3D)        3PV6 (3D)    
Secondary accessions: B0S8F2 B0S8F4 B0S8F5 O14930 O14932 O95667 O95668 O95669 Q5ST89 Q5ST90
Q5ST91 Q5ST92 Q5STA3
Alternative splicing: 6 isoforms:  O14931-1   O14931-2   O14931-3   O14931-4   O14931-5   O14931-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCR3: NX_O14931

Explore proteomics data for NCR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn121

  • See NCR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138938.1  NP_001138939.1  NP_667341.1  

    ENSEMBL proteins: 
     ENSP00000342156   ENSP00000365241   ENSP00000365240   ENSP00000365239  

    NCR3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for NCR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O14931

    ProtoNet protein and cluster: O14931

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
    Similarity: Belongs to the natural cytotoxicity receptor (NCR) family
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    NCR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCTR3_HUMAN, O14931
    Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural
    killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC)
    maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK
    cells to release TNFA and IFNG, which promotes DC maturation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NCR3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NCR3:
     Abundance of large cells with   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCR3
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    Sino Biological Human cDNA Clone for NCR3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCTR3_HUMAN, O14931: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS7590964

    NCR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NCR3):
        Natural killer cell mediated cytotoxicity


    NCR3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NCR3: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCR3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NCR3 (O149313 ENSP000003421564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD59P139873, ENSP000003402104I2D: score=3 STRING: ENSP00000340210
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response NAS10941844
    GO:0006955immune response NAS10941844
    GO:0008037cell recognition TAS16304049
    GO:0045954positive regulation of natural killer cell mediated cytotoxicity IMP16304049

    NCR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCR3 (NCTR3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NCR3 gene (3 alternative transcripts): 
    NM_001145466.1  NM_001145467.1  NM_147130.2  

    Unigene Cluster for NCR3:

    Natural cytotoxicity triggering receptor 3
    Hs.509513  [show with all ESTs]
    Unigene Representative Sequence: BM917537
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495600 ENST00000491161 ENST00000340027(uc003nuv.2) ENST00000376073(uc003nuw.2)
    ENST00000376072(uc003nux.1) ENST00000376071
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat NCR3

    Additional mRNA sequence: 

    AB055881.1 AF031136.1 AF031137.1 AF031138.1 AJ223153.1 BC018752.1 BC052582.1 

    3 DOTS entries:

    DT.95255974  DT.100748329  DT.87046170 

    9 AceView cDNA sequences:

    BC018752 AF031137 AF031136 NM_147130 AF031138 BC052582 AB055881 AJ223153 
    BV199558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAGCTCA
    NCR3 Expression
    About this image

    NCR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509513

    UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
    Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including NCR3: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for NCR3 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncr3-ps5 natural cytotoxicity triggering receptor 3, pseudogene   --   17 (18.59 cM) 35180535 


    ENSEMBL Gene Tree for NCR3 (if available)
    TreeFam Gene Tree for NCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NCTR3_HUMAN, O14931: A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148]


    Selected SNPs for NCR3 (see all 192)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124706621,2
    C--31344762(+) TTGGGG/TGCCTC 3 -- int10--------
    rs412688921,2
    C,F--31346631(+) TGCGCG/ACTTGT 3 -- int11Minor allele frequency- A:0.13NA 120
    rs2016111171,2
    C--31347914(+) TTTTT-/TTTTTT 3 -- us2k10--------
    rs285216661,2
    C,F--31473132(+) GAGAGG/AGAGAG 2 -- ds50011Minor allele frequency- A:0.50NA 4
    rs287321441,2
    C,F,H--31473157(+) GGAGAG/AAAGTA 2 -- ds500112Minor allele frequency- A:0.05NS EA NA 1916
    rs1454408611,2
    C--31473188(+) CAGAAC/TTCACA 2 -- ds50010--------
    rs1842031291,2
    C--31473247(+) CCCAGA/GCCCAG 2 -- ds50010--------
    rs2019173451,2
    C--31473481(+) TGGTCC/TCCCCA 2 -- ds50011Minor allele frequency- T:0.00EU 1311
    rs10522481,2
    C,F,A,H--31473533(+) TCAAAT/ATGATC 3 -- ds500132Minor allele frequency- A:0.28MN NS EA NA WA CSA 3554
    rs1381557671,2
    C--31473553(+) ACTTAC/TGTGGC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for NCR3 (31556660 - 31560762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NCR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): NCR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCR3
    DNA2.0 Custom Variant and Variant Library Synthesis for NCR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611550   
    OMIM disorders: 609148  
    Selected diseases for NCR3 (see all 26):    
    About MalaCards
    neonatal abstinence syndrome    malaria, mild    proliferative vitreoretinopathy    cytomegalovirus infection
    malaria    plasmodium falciparum malaria    hematopoietic stem cell transplantation    pregnancy loss
    gastrointestinal stromal tumor    allergic contact dermatitis    contact dermatitis    pulmonary function
    acute myeloid leukemia    systemic lupus erythematosus    hepatitis c virus    cervical cancer
    lupus erythematosus    hepatitis c    myeloid leukemia    dermatitis


    NCR3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NCR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.5 12 10562324 (2), 11782277 (1), 11606250 (1), 12646700 (1) (see all 8)
    leukemia 19.1 2 15654827 (1), 16940427 (1)
    necrosis 2.64 2 11782277 (1), 19580844 (1)

    Genetic Association Database (GAD): NCR3
    Human Genome Epidemiology (HuGE) Navigator: NCR3 (11 documents)

    Export disorders for NCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCR3 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with NCR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PubMed id 17208487)1, 2, 4 Delahaye N.F.... Rihet P. (Microbes Infect. 2007)
    2. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PubMed id 8824804)1, 2, 3 Nalabolu S.R.... Weissman S.M. (Genomics 1996)
    3. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. (PubMed id 11782277)1, 3, 9 Sato M....Yabe T. (Tissue Antigens 2001)
    4. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. (PubMed id 10562324)1, 2, 9 Pende D.... Moretta A. (J. Exp. Med. 1999)
    5. Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. (PubMed id 21444796)1, 2 Joyce M.G.... Sun P.D. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    6. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    7. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. (PubMed id 21422170)1, 2 Li Y.... Mariuzza R.A. (J. Exp. Med. 2011)
    8. A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project. (PubMed id 20663564)1, 4 Rojas J....Carracedo A. (Ophthalmology 2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (BMC Med. Genet. 2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 259197 HGNC: 19077 AceView: NCR3 Ensembl:ENSG00000204475 euGenes: HUgn259197
    ECgene: NCR3 Kegg: 259197 H-InvDB: NCR3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for NCR3 gene:
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