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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCR3 Gene

protein-coding   GIFtS: 57
GCID: GC06M031575

Natural Cytotoxicity Triggering Receptor 3

(Previous name: lymphocyte antigen 117)
(Previous symbol: LY117)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Natural Cytotoxicity Triggering Receptor 31 2     NKp302 3
LY1171 2 3     CD3372 5
1C72 3 5     MALS2
Lymphocyte Antigen 1171 2     Activating NK-A1 Receptor2
Activating Natural Killer Receptor P302 3     CD337 Antigen3
Natural Killer Cell P30-Related Protein2 3     NKP305
NK-p302 3     

External Ids:    HGNC: 190771   Entrez Gene: 2591972   Ensembl: ENSG000002044757   OMIM: 6115505   UniProtKB: O149313   

Export aliases for NCR3 gene to outside databases

Previous GC identifers: GC06M031610 GC06M031327 GC06M031660 GC06M031664 GC06M031557 GC06M031343 GC06M031558


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCR3 Gene:
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of
tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide
polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility.
Three transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, May
2010)

GeneCards Summary for NCR3 Gene: 
NCR3 (natural cytotoxicity triggering receptor 3) is a protein-coding gene. Diseases associated with NCR3 include neonatal abstinence syndrome, and malaria, mild, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells.

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural
killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC)
maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK
cells to release TNFA and IFNG, which promotes DC maturation

Gene Wiki entry for NCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCR3 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCR3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031575:  view genomic region     (about GC identifiers)

Start:
31,556,660 bp from pter      End:
31,560,762 bp from pter
Size:
4,103 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167244 2,871,378-2,875,480      Chr6-,NT_167245 2,842,205-2,846,307      Chr6-,NT_167249 2,887,462-2,891,563     
Chr6-,NT_167247 2,936,361-2,940,463      Chr6-,NT_167248 2,850,302-2,854,402      Chr6-,NT_167246 2,899,544-2,903,646     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931 (See protein sequence)
Recommended Name: Natural cytotoxicity triggering receptor 3 precursor  
Size: 201 amino acids; 21593 Da
Subunit: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to
NCR3LG1. Interacts with and is activated by binding to BAG6
Subcellular location: Cell membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for NCR3:
3NOI (3D)        3PV6 (3D)    
Secondary accessions: B0S8F2 B0S8F4 B0S8F5 O14930 O14932 O95667 O95668 O95669 Q5ST89 Q5ST90
Q5ST91 Q5ST92 Q5STA3
Alternative splicing: 6 isoforms:  O14931-1   O14931-2   O14931-3   O14931-4   O14931-5   O14931-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCR3: NX_O14931

Explore proteomics data for NCR3 at MOPED 

NCR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NCR3 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001138938.1  NP_001138939.1  NP_667341.1  

ENSEMBL proteins: 
 ENSP00000342156   ENSP00000365241   ENSP00000365240   ENSP00000365239  

Human Recombinant Protein Products for NCR3: 
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Sino Biological Recombinant Protein for NCR3
Sino Biological Cell Lysate for NCR3 
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Cloud-Clone Corp. Proteins for NCR3 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral to plasma membrane TAS7590964

NCR3 for ontologies           About GeneDecksing



NCR3 Antibody Products: 
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Cloud-Clone Corp. ELISAs for NCR3 
Cloud-Clone Corp. CLIAs for NCR3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom
 IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry O14931

ProtoNet protein and cluster: O14931

1 Blocks protein domain: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
Similarity: Belongs to the natural cytotoxicity receptor (NCR) family
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


NCR3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NCTR3_HUMAN, O14931
Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural
killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC)
maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK
cells to release TNFA and IFNG, which promotes DC maturation

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
NCR3 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for NCR3:
 Abundance of large cells with   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for NCR3 
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCR3 

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for NCR3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response Fc epsilon RI pathway
Natural killer cell mediated cytotoxicity0.31

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1         Kegg Pathway  (Kegg details for NCR3):
    Natural killer cell mediated cytotoxicity


NCR3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCR3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for NCR3 (O149313 ENSP000003421564) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CD59P139873, ENSP000003402104I2D: score=3 STRING: ENSP00000340210
CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response NAS10941844
GO:0006955immune response NAS10941844
GO:0008037cell recognition TAS16304049
GO:0045954positive regulation of natural killer cell mediated cytotoxicity IMP16304049

NCR3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NCR3 (NCTR3)

Search CenterWatch for drugs/clinical trials and news about NCR3 / NCTR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NCR3 gene (3 alternative transcripts): 
NM_001145466.1  NM_001145467.1  NM_147130.2  

Unigene Cluster for NCR3:

Natural cytotoxicity triggering receptor 3
Hs.509513  [show with all ESTs]
Unigene Representative Sequence: BM917537
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000495600 ENST00000491161 ENST00000340027(uc003nuv.2) ENST00000376073(uc003nuw.2)
ENST00000376072(uc003nux.1) ENST00000376071
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCR3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NCR3
SwitchGear 3'UTR luciferase reporter plasmidNCR3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for NCR3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCR3
Clone
Products:
     
OriGene clones in human, mouse for NCR3 (see all 13)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): NCR3 (NM_001145466)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCR3
Sirion Biotech Customized lentivirus for stable overexpression of NCR3 
                     Customized lentivirus expression plasmids for stable overexpression of NCR3 
Primer
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OriGene qPCR primer pairs and template standards for NCR3
OriGene qSTAR qPCR primer pairs in human, mouse for NCR3
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NCR3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCR3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR3

Additional mRNA sequence: 

AB055881.1 AF031136.1 AF031137.1 AF031138.1 AJ223153.1 BC018752.1 BC052582.1 

3 DOTS entries:

DT.95255974  DT.100748329  DT.87046170 

9 AceView cDNA sequences:

BC018752 NM_147130 BC052582 AF031137 AF031138 AF031136 AB055881 AJ223153 
BV199558 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NCR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGGAGCTCA
NCR3 Expression
About this image


See NCR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCR3

SOURCE GeneReport for Unigene cluster: Hs.509513

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen

    SABiosciences Expression via Pathway-Focused PCR Array including NCR3: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for NCR3
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for NCR3 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ncr3-ps5 natural cytotoxicity triggering receptor 3, pseudogene   --   17 (18.59 cM) 35180535 


ENSEMBL Gene Tree for NCR3 (if available)
TreeFam Gene Tree for NCR3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NCTR3_HUMAN, O14931
Polymorphism: A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148]


10/192 SNPs in NCR3 are shown (see all 192)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1124706621,2
C--31344762(+) TTGGGG/TGCCTC 3 -- int10--------
rs412688921,2
C,F--31346631(+) TGCGCG/ACTTGT 3 -- int11Minor allele frequency- A:0.13NA 120
rs2016111171,2
C--31347914(+) TTTTT-/TTTTTT 3 -- us2k10--------
rs285216661,2
C,F--31473132(+) GAGAGG/AGAGAG 2 -- ds50011Minor allele frequency- A:0.50NA 4
rs287321441,2
C,F,H--31473157(+) GGAGAG/AAAGTA 2 -- ds500112Minor allele frequency- A:0.05NS EA NA 1916
rs1454408611,2
C--31473188(+) CAGAAC/TTCACA 2 -- ds50010--------
rs1842031291,2
C--31473247(+) CCCAGA/GCCCAG 2 -- ds50010--------
rs2019173451,2
C--31473481(+) TGGTCC/TCCCCA 2 -- ds50011Minor allele frequency- T:0.00EU 1311
rs10522481,2
C,F,A,H--31473533(+) TCAAAT/ATGATC 3 -- ds500132Minor allele frequency- A:0.28MN NS EA NA WA CSA 3554
rs1381557671,2
C--31473553(+) ACTTAC/TGTGGC 3 -- ds50010--------

HapMap Linkage Disequilibrium report for NCR3 (31556660 - 31560762 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for NCR3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv830627CNV Loss17160897
nsv884418CNV Gain21882294


Human Gene Mutation Database (HGMD): NCR3
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing NCR3
DNA2.0 Custom Variant and Variant Library Synthesis for NCR3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611550   
OMIM disorders: 609148  
20 diseases for NCR3:    About MalaCards
neonatal abstinence syndrome    malaria, mild    proliferative vitreoretinopathy    malaria
cytomegalovirus infection    hematopoietic stem cell transplantation    plasmodium falciparum malaria    gastrointestinal stromal tumor
acute myeloid leukemia    systemic lupus erythematosus    cervical cancer    hepatitis c
myeloid leukemia    lupus erythematosus    dermatitis    obesity
cervicitis    hepatocellular carcinoma    leukemia    hepatitis


NCR3 for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for NCR3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 30.5 12 10562324 (2), 11782277 (1), 11606250 (1), 12646700 (1) (see all 8)
leukemia 19.1 2 15654827 (1), 16940427 (1)
necrosis 2.64 2 11782277 (1), 19580844 (1)

Genetic Association Database (GAD): NCR3
Human Genome Epidemiology (HuGE) Navigator: NCR3 (11 documents)

Export disorders for NCR3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NCR3 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with NCR3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PubMed id 17208487)1, 2, 4 Delahaye N.F.... Rihet P. (2007)
  2. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PubMed id 8824804)1, 2, 3 Nalabolu S.R.... Weissman S.M. (1996)
  3. Identification of novel single nucleotide substitutio ns in the NKp30 gene expressed in human natural killer cells. (PubMed id 11782277)1, 3, 9 Sato M....Yabe T. (2001)
  4. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. (PubMed id 10562324)1, 2, 9 Pende D.... Moretta A. (1999)
  5. Crystal structure of human natural cytotoxicity recep tor NKp30 and identification of its ligand binding site. (PubMed id 21444796)1, 2 Joyce M.G....Sun P.D. (2011)
  6. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (2011)
  7. Structure of the human activating natural cytotoxicit y receptor NKp30 bound to its tumor cell ligand B7-H6. (PubMed id 21422170)1, 2 Li Y....Mariuzza R.A. (2011)
  8. A strong genetic association between the tumor necros is factor locus and proliferative vitreoretinopathy: the retina 4 project. (PubMed id 20663564)1, 4 Rojas J....Carracedo A. (2010)
  9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
  10. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collabora tive study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 259197 HGNC: 19077 AceView: NCR3 Ensembl:ENSG00000204475 euGenes: HUgn259197
ECgene: NCR3 Kegg: 259197 H-InvDB: NCR3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NCR3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NCR3 gene:
Search GeneIP for patents involving NCR3

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