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Aliases for NCR3 Gene

Aliases for NCR3 Gene

  • Natural Cytotoxicity Triggering Receptor 3 2 3
  • NKp30 3 4 6
  • 1C7 3 4 6
  • Natural Killer Cell P30-Related Protein 3 4
  • Activating Natural Killer Receptor P30 3 4
  • Lymphocyte Antigen 117 2 3
  • NK-P30 3 4
  • LY117 3 4
  • CD337 3 6
  • MALS 3 6
  • Activating NK-A1 Receptor 3
  • CD337 Antigen 4

External Ids for NCR3 Gene

Previous HGNC Symbols for NCR3 Gene

  • LY117

Previous GeneCards Identifiers for NCR3 Gene

  • GC06M031610
  • GC06M031327
  • GC06M031660
  • GC06M031664
  • GC06M031557
  • GC06M031343
  • GC06M031558
  • GC06M031575
  • GC06M031677

Summaries for NCR3 Gene

Entrez Gene Summary for NCR3 Gene

  • The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for NCR3 Gene

NCR3 (Natural Cytotoxicity Triggering Receptor 3) is a Protein Coding gene. Diseases associated with NCR3 include malaria, mild and allergic contact dermatitis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells.

UniProtKB/Swiss-Prot for NCR3 Gene

  • Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Gene Wiki entry for NCR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR3 Gene

Genomics for NCR3 Gene

Regulatory Elements for NCR3 Gene

Genomic Location for NCR3 Gene

Start:
31,588,883 bp from pter
End:
31,592,994 bp from pter
Size:
4,112 bases
Orientation:
Minus strand

Genomic View for NCR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR3 Gene

  • Protein details for NCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14931-NCTR3_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 3
    Protein Accession:
    O14931
    Secondary Accessions:
    • B0S8F2
    • B0S8F4
    • B0S8F5
    • O14930
    • O14932
    • O95667
    • O95668
    • O95669
    • Q5ST89
    • Q5ST90
    • Q5ST91
    • Q5ST92
    • Q5STA3

    Protein attributes for NCR3 Gene

    Size:
    201 amino acids
    Molecular mass:
    21593 Da
    Quaternary structure:
    • Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

    Three dimensional structures from OCA and Proteopedia for NCR3 Gene

    Alternative splice isoforms for NCR3 Gene

neXtProt entry for NCR3 Gene

Proteomics data for NCR3 Gene at MOPED

Post-translational modifications for NCR3 Gene

  • Glycosylation at Asn42 and Asn121

Other Protein References for NCR3 Gene

No data available for DME Specific Peptides for NCR3 Gene

Domains for NCR3 Gene

Gene Families for NCR3 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for NCR3 Gene

Suggested Antigen Peptide Sequences for NCR3 Gene

Graphical View of Domain Structure for InterPro Entry

O14931

UniProtKB/Swiss-Prot:

NCTR3_HUMAN :
  • O14931
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR3: view

Function for NCR3 Gene

Molecular function for NCR3 Gene

UniProtKB/Swiss-Prot Function: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Gene Ontology (GO) - Molecular Function for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NCR3: view
genes like me logo Genes that share phenotypes with NCR3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCR3 Gene

Localization for NCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR3 Gene COMPARTMENTS Subcellular localization image for NCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 7590964
genes like me logo Genes that share ontologies with NCR3: view

Pathways for NCR3 Gene

genes like me logo Genes that share pathways with NCR3: view

Pathways by source for NCR3 Gene

1 KEGG pathway for NCR3 Gene

Interacting Proteins for NCR3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342156%0d%0a9606.ENSP00000341637%0d%0a9606.ENSP00000354782%0d%0a9606.ENSP00000340210%0d%0a
Selected Interacting proteins: ENSP00000342156 O14931-NCTR3_HUMAN for NCR3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response NAS 10941844
GO:0006955 immune response NAS 10941844
GO:0008037 cell recognition TAS 16304049
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP 16304049
genes like me logo Genes that share ontologies with NCR3: view

Transcripts for NCR3 Gene

mRNA/cDNA for NCR3 Gene

Unigene Clusters for NCR3 Gene

Natural cytotoxicity triggering receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCR3 Gene

No ASD Table

Relevant External Links for NCR3 Gene

GeneLoc Exon Structure for
NCR3
ECgene alternative splicing isoforms for
NCR3

Expression for NCR3 Gene

mRNA expression in normal human tissues for NCR3 Gene

mRNA differential expression in normal tissues according to GTEx for NCR3 Gene

This gene is overexpressed in Whole Blood (29.7) and Spleen (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NCR3 Gene

SOURCE GeneReport for Unigene cluster for NCR3 Gene Hs.509513

mRNA Expression by UniProt/SwissProt for NCR3 Gene

O14931-NCTR3_HUMAN
Tissue specificity: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
genes like me logo Genes that share expressions with NCR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCR3 Gene

Orthologs for NCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR3 35
  • 99.5 (n)
  • 99 (a)
NCR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCR3 35
  • 84.02 (n)
  • 77.78 (a)
NCR3 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCR3 35
  • 82.22 (n)
  • 74.87 (a)
NCR3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncr3-ps 16
rat
(Rattus norvegicus)
Mammalia Ncr3 35
  • 78.64 (n)
  • 67.66 (a)
Species with no ortholog for NCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR3 Gene

ENSEMBL:
Gene Tree for NCR3 (if available)
TreeFam:
Gene Tree for NCR3 (if available)

Paralogs for NCR3 Gene

No data available for Paralogs for NCR3 Gene

Variants for NCR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NCR3 Gene

O14931-NCTR3_HUMAN
A genetic variation in NCR3 is associated with mild malaria susceptibility [MIM:609148]

Sequence variations from dbSNP and Humsavar for NCR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2515920 -- 31,594,838(-) TTATT(A/T)TTTTT upstream-variant-2KB
rs2736190 -- 31,593,434(-) tgggc(A/G)acaga upstream-variant-2KB
rs2736191 other 31,593,133(-) TCCTG(C/G)AGGCT upstream-variant-2KB, intron-variant
rs2736192 -- 31,591,576(-) GGCCT(C/T)CCAAA intron-variant
rs2857599 -- 31,594,373(-) agaga(C/T)gaatg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCR3 Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Relevant External Links for NCR3 Gene

HapMap Linkage Disequilibrium report
NCR3
Human Gene Mutation Database (HGMD)
NCR3

Disorders for NCR3 Gene

(1) OMIM Diseases for NCR3 Gene (611550)

(3) Novoseek inferred disease relationships for NCR3 Gene

Disease -log(P) Hits PubMed IDs
tumors 30.5 9
leukemia 19.1 2
necrosis 2.64 2

Relevant External Links for NCR3

Genetic Association Database (GAD)
NCR3
Human Genome Epidemiology (HuGE) Navigator
NCR3
genes like me logo Genes that share disorders with NCR3: view

No data available for UniProtKB/Swiss-Prot for NCR3 Gene

Publications for NCR3 Gene

  1. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. (PMID: 10562324) Pende D. … Moretta A. (J. Exp. Med. 1999) 3 4 23
  2. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. (PMID: 11782277) Sato M. … Yabe T. (Tissue Antigens 2001) 2 3 23
  3. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PMID: 8824804) Nalabolu S.R. … Weissman S.M. (Genomics 1996) 2 3 4
  4. Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. (PMID: 17208487) Delahaye N.F. … Rihet P. (Microbes Infect. 2007) 3 4 48
  5. Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. (PMID: 18055229) Pogge von Strandmann E. … Engert A. (Immunity 2007) 3 4

Products for NCR3 Gene

Sources for NCR3 Gene

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