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Aliases for NCR2 Gene

Aliases for NCR2 Gene

  • Natural Cytotoxicity Triggering Receptor 2 2 3 5
  • Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44) 2 3
  • Natural Killer Cell P44-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P44 3 4
  • NKP44 3 4
  • LY95 3 4
  • Lymphocyte Antigen 95 Homolog (Activating NK-Receptor; NK-P44) 3
  • NK Cell Activating Receptor (NKp44) 3
  • Lymphocyte Antigen 95 Homolog 4
  • CD336 Antigen 4
  • DJ149M18.1 3
  • CD336 3

External Ids for NCR2 Gene

Previous HGNC Symbols for NCR2 Gene

  • LY95

Previous GeneCards Identifiers for NCR2 Gene

  • GC06P041299
  • GC06P041350
  • GC06P041411
  • GC06P041022

Summaries for NCR2 Gene

GeneCards Summary for NCR2 Gene

NCR2 (Natural Cytotoxicity Triggering Receptor 2) is a Protein Coding gene. Diseases associated with NCR2 include Progesterone-Receptor Positive Breast Cancer. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TREML4.

UniProtKB/Swiss-Prot for NCR2 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR2 Gene

Genomics for NCR2 Gene

Regulatory Elements for NCR2 Gene

Enhancers for NCR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NCR2 gene promoter:

Genomic Location for NCR2 Gene

41,335,655 bp from pter
41,350,887 bp from pter
15,233 bases
Plus strand

Genomic View for NCR2 Gene

Genes around NCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR2 Gene

Proteins for NCR2 Gene

  • Protein details for NCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natural cytotoxicity triggering receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q9H562
    • Q9H563
    • Q9H564
    • Q9UMT1
    • Q9UMT2

    Protein attributes for NCR2 Gene

    276 amino acids
    Molecular mass:
    30677 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

    Three dimensional structures from OCA and Proteopedia for NCR2 Gene

    Alternative splice isoforms for NCR2 Gene


neXtProt entry for NCR2 Gene

Proteomics data for NCR2 Gene at MOPED

Post-translational modifications for NCR2 Gene

  • Glycosylation at Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR2 Gene

Antibody Products

  • Abcam antibodies for NCR2

No data available for DME Specific Peptides for NCR2 Gene

Domains & Families for NCR2 Gene

Gene Families for NCR2 Gene

Protein Domains for NCR2 Gene

Suggested Antigen Peptide Sequences for NCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR2: view

Function for NCR2 Gene

Molecular function for NCR2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Phenotypes for NCR2 Gene

genes like me logo Genes that share phenotypes with NCR2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR2 Gene

Localization for NCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NCR2 Gene COMPARTMENTS Subcellular localization image for NCR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for NCR2 Gene

Pathways & Interactions for NCR2 Gene

genes like me logo Genes that share pathways with NCR2: view

Interacting Proteins for NCR2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362181 O95944-NCTR2_HUMAN for NCR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with NCR2: view

No data available for SIGNOR curated interactions for NCR2 Gene

Drugs & Compounds for NCR2 Gene

(1) Drugs for NCR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NCR2: view

Transcripts for NCR2 Gene

mRNA/cDNA for NCR2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR2 Gene

Natural cytotoxicity triggering receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP2: -

Relevant External Links for NCR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCR2 Gene

mRNA expression in normal human tissues for NCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.9).

SOURCE GeneReport for Unigene cluster for NCR2 Gene Hs.194721

mRNA Expression by UniProt/SwissProt for NCR2 Gene

Tissue specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
genes like me logo Genes that share expression patterns with NCR2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NCR2 Gene

Orthologs for NCR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NCR2 35
  • 76.52 (n)
  • 63.98 (a)
NCR2 36
  • 53 (a)
(Pan troglodytes)
Mammalia NCR2 35
  • 98.79 (n)
  • 96.74 (a)
NCR2 36
  • 97 (a)
(Mus musculus)
Mammalia B430306N03Rik 36
  • 19 (a)
Species with no ortholog for NCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR2 Gene

Gene Tree for NCR2 (if available)
Gene Tree for NCR2 (if available)

Paralogs for NCR2 Gene

Paralogs for NCR2 Gene

(1) SIMAP similar genes for NCR2 Gene using alignment to 1 proteins: Pseudogenes for NCR2 Gene

genes like me logo Genes that share paralogs with NCR2: view

Variants for NCR2 Gene

Sequence variations from dbSNP and Humsavar for NCR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9471577 - 41,336,257(+) GGACG(A/G)TGGCT reference, missense
rs2236369 - 41,341,814(+) AGACC(C/T)CCTGG reference, missense
rs2273961 - 41,350,686(+) GGACA(A/T)ATGGT reference, missense
rs2273962 - 41,350,700(+) AAACC(A/G)TGATG reference, synonymous-codon, missense
rs6458216 -- 41,344,998(+) GTCTC(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCR2 Gene

Variant ID Type Subtype PubMed ID
dgv6836n71 CNV Gain 21882294

Variation tolerance for NCR2 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NCR2 Gene

Disorders for NCR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
progesterone-receptor positive breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search NCR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR2 Gene

Publications for NCR2 Gene

  1. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. (PMID: 10049942) Cantoni C. … Biassoni R. (J. Exp. Med. 1999) 2 3 4 23 67
  2. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y. … Lin Q. (Fertil. Steril. 2008) 3 23
  3. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. (PMID: 18092004) Byrd A. … Watzl C. (PLoS ONE 2007) 3 23
  4. Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. (PMID: 15728472) Poggi A. … Zocchi M.R. (J. Immunol. 2005) 3 23
  5. Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. (PMID: 15941912) Fuchs A. … Colonna M. (Blood 2005) 3 23

Products for NCR2 Gene

Sources for NCR2 Gene