NCR2 Gene

Aliases
for NCR2 gene

Previous GC identifers: GC06P041299 GC06P041350 GC06P041411 GC06P041022

Summaries
for NCR2 gene

Genomic Views
for NCR2 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007592.15  

SwitchGear Promoter luciferase reporter plasmid: NCR2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCR2

NCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041303:  view genomic region     (about GC identifiers)

Proteins
for NCR2 gene

1 PDB 3D structure from and Proteopedia for NCR2:

1HKF (3D)    

Explore the universe of human proteins at neXtProt for NCR2: NX_O95944

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NCR2 (NKp44/NCR2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NCR2 OriGene Protein Over-expression Lysate: NCR2 OriGene Custom Protein Services for NCR2
	GenScript Custom Purified and Recombinant Proteins Services for NCR2
	Novus Biologicals NCR2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NCR2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for NCR2 (NKp44/NCR2)
	OriGene Antibodies: NCR2 OriGene Custom Antibody Services for NCR2
	GenScript Custom Superior Antibodies Services for NCR2
	Novus Biologicals NCR2 Antibody
	Abcam antibodies for NCR2
	Uscn Antibodies for NCR2
	Search ThermoFisher Antibodies for NCR2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for NCR2 (NKp44/NCR2)
	GenScript Custom Assay Services for NCR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NCR2

Protein Domains /
Families
for NCR2 gene

ProtoNet protein and cluster: O95944

Function
for NCR2 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCR2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate NCR2:
		hsa-miR-590-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCR2 OriGene shRNA RFP: NCR2 OriGene siRNA: NCR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCR2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NCR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCR2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCR2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NCR2 (NM_001199509)
		Sino Biological Human cDNA Clone for NCR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NCR2
		Search LifeMap BioReagents cell lines for NCR2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for NCR2 gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Innate Immune System 0.46
2	Immune response CD16 signaling in NK cells	Immune response Role of DAP12 receptors in NK cells 0.32 Immune response_Role of DAP12 receptors in NK cells 0.32
3	Natural killer cell mediated cytotoxicity	Natural killer cell mediated cytotoxicity 1.00
4	Signaling by FGFR	DAP12 interactions 0.76

1 EMD Millipore Pathway for NCR2

Immune response Role of DAP12 receptors in NK cells

1 GeneGo (Thomson Reuters) Pathway for NCR2

Immune response Role of DAP12 receptors in NK cells

3        Reactome Pathways for NCR2

	DAP12 interactions
	Immune System
	Innate Immune System

1         Kegg Pathway  (Kegg details for NCR2)

Natural killer cell mediated cytotoxicity

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for NCR2 gene

Transcripts
for NCR2 gene

Expression
for NCR2 gene

NCR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGATCTGA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Natural killer-like cells (Derivation of hemato...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NCR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR2

Orthologs
for NCR2 gene

Paralogs
for NCR2 gene

Paralogs for NCR2 gene

TREML4²  

1 SIMAP similar gene for NCR2 using alignment to 1 protein entry:     NCTR2_HUMAN:

TREML4

NCR2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for NCR2
PGOHUM00000243620

Genomic Variants
for NCR2 gene

10/408 NCBI SNPs in NCR2 are shown (see all 408)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs356737641,2	C,	--	41030079(+)	ACAAC-/TTGGTT	1	--	int1		1		NA	2
rs6406901,2	H	--	41301546(+)	GTGCAG/CATGGT	3	--	us2k1		4		NS EA	420
rs6377771,2	H	--	41301573(+)	CCCTAG/TGGTGC	3	--	us2k1		4		NS EA	416
rs734353561,2	C,	--	41301586(+)	AAGGCC/TCCAAG	3	--	us2k1		2		WA	120
rs734353571,2	C,	--	41301655(+)	GGGGCA/GGATTC	3	--	us2k1		2		WA	120
rs789087561,2	F,	--	41301664(+)	TCCCCA/G/TCTTTG	3	--	us2k1		1		NA	120
rs745725691,2	C,	--	41301681(+)	CCTGTC/ACCCTG	3	--	us2k1		2		WA	120
rs6382801,2	H	--	41301707(+)	CTCTGA/TCACAG	3	--	us2k1		4		NS EA	420
rs93573551,2	C,F,A,H,	--	41301735(+)	CTGGCT/CGCAGG	3	--	us2k1		16		NA NS EA WA	918
rs737332121,2	C,	--	41301736(+)	TGGCTG/ACAGGC	3	--	us2k1		2		WA	120

HapMap Linkage Disequilibrium report for NCR2 (41303393 - 41318625 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NCR2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCR2

DNA2.0 Custom Variant and Variant Library Synthesis for NCR2

Disorders / Diseases
for NCR2 gene

20/21 diseases for NCR2

2 Novoseek disease relationships for NCR2 gene    About this table

Publications
for NCR2 gene

PubMed articles for NCR2 gene, integrated from 9 sources (see all 75): (articles sorted by number of sources associating them with NCR2)

Utopia: connect your pdf to the dynamic world of online information

1. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. (PubMed id 10049942)^{1, 2, 3, 9} Cantoni C.... Biassoni R. (1999)
2. The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. (PubMed id 12791260)^{1, 2} Cantoni C.... Bordo D. (2003)
3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
4. NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. (PubMed id 14707061)^{1, 9} Campbell K.S....Catina T.L. (2004)
5. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. (PubMed id 18092004)^{1, 9} Byrd A....Watzl C. (2007)
6. Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D. (PubMed id 16210654)^{1, 9} Forte P....Seebach J.D. (2005)
7. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PubMed id 18023431)^{1, 9} Zhang Y....Lin Q. (2008)
8. Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. (PubMed id 15941912)^{1, 9} Fuchs A....Colonna M. (2005)
9. Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. (PubMed id 15728472)^{1, 9} Poggi A....Zocchi M.R. (2005)
10. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. (PubMed id 22674989)¹ Madrid A.S. and Ganem D. (2012)

External Searches for NCR2 gene

Genome Databases showing NCR2 gene

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Specialized Databases showing NCR2 gene

Products
for NCR2 gene