Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCR2 Gene

Aliases for NCR2 Gene

  • Natural Cytotoxicity Triggering Receptor 2 2 3
  • NKP44 3 4 6
  • LY95 3 4 6
  • Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44) 2 3
  • Natural Killer Cell P44-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P44 3 4
  • Lymphocyte Antigen 95 Homolog (Activating NK-Receptor; NK-P44) 3
  • NK Cell Activating Receptor (NKp44) 3
  • Lymphocyte Antigen 95 Homolog 4
  • CD336 Antigen 4
  • DJ149M18.1 3
  • CD336 3

External Ids for NCR2 Gene

Previous HGNC Symbols for NCR2 Gene

  • LY95

Previous GeneCards Identifiers for NCR2 Gene

  • GC06P041299
  • GC06P041350
  • GC06P041411
  • GC06P041022

Summaries for NCR2 Gene

GeneCards Summary for NCR2 Gene

NCR2 (Natural Cytotoxicity Triggering Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TREML4.

UniProtKB/Swiss-Prot for NCR2 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR2 Gene

Genomics for NCR2 Gene

Regulatory Elements for NCR2 Gene

Transcription factor binding sites by QIAGEN in the NCR2 gene promoter:

Genomic Location for NCR2 Gene

Start:
41,335,655 bp from pter
End:
41,350,887 bp from pter
Size:
15,233 bases
Orientation:
Plus strand

Genomic View for NCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR2 Gene

Proteins for NCR2 Gene

  • Protein details for NCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95944-NCTR2_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 2
    Protein Accession:
    O95944
    Secondary Accessions:
    • Q9H562
    • Q9H563
    • Q9H564
    • Q9UMT1
    • Q9UMT2

    Protein attributes for NCR2 Gene

    Size:
    276 amino acids
    Molecular mass:
    30677 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

    Three dimensional structures from OCA and Proteopedia for NCR2 Gene

    Alternative splice isoforms for NCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCR2 Gene

Proteomics data for NCR2 Gene at MOPED

Post-translational modifications for NCR2 Gene

  • Glycosylation at Asn180
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NCR2 Gene

Domains for NCR2 Gene

Gene Families for NCR2 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for NCR2 Gene

Suggested Antigen Peptide Sequences for NCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95944

UniProtKB/Swiss-Prot:

NCTR2_HUMAN :
  • O95944
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR2: view

Function for NCR2 Gene

Molecular function for NCR2 Gene

UniProtKB/Swiss-Prot Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10049942
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NCR2: view

Phenotypes for NCR2 Gene

GenomeRNAi human phenotypes for NCR2:
genes like me logo Genes that share phenotypes with NCR2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCR2 Gene

Localization for NCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR2 Gene COMPARTMENTS Subcellular localization image for NCR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10049942
genes like me logo Genes that share ontologies with NCR2: view

Pathways for NCR2 Gene

genes like me logo Genes that share pathways with NCR2: view

Pathways by source for NCR2 Gene

1 Reactome pathway for NCR2 Gene
1 KEGG pathway for NCR2 Gene
1 GeneGo (Thomson Reuters) pathway for NCR2 Gene

Interacting Proteins for NCR2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362181%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000362181 O95944-NCTR2_HUMAN for NCR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 10049942
GO:0007165 signal transduction TAS 10049942
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with NCR2: view

Compounds for NCR2 Gene

(1) Novoseek inferred chemical compound relationships for NCR2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 5
genes like me logo Genes that share compounds with NCR2: view

Transcripts for NCR2 Gene

mRNA/cDNA for NCR2 Gene

(5) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR2 Gene

Natural cytotoxicity triggering receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for NCR2 Gene

GeneLoc Exon Structure for
NCR2
ECgene alternative splicing isoforms for
NCR2

Expression for NCR2 Gene

mRNA expression in normal human tissues for NCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (4.9).

SOURCE GeneReport for Unigene cluster for NCR2 Gene Hs.194721

mRNA Expression by UniProt/SwissProt for NCR2 Gene

O95944-NCTR2_HUMAN
Tissue specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
genes like me logo Genes that share expressions with NCR2: view

In Situ Assay Products

No data available for Protein expression for NCR2 Gene

Orthologs for NCR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR2 35
  • 98.79 (n)
  • 96.74 (a)
NCR2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCR2 35
  • 76.52 (n)
  • 63.98 (a)
NCR2 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B430306N03Rik 36
  • 19 (a)
ManyToMany
Species with no ortholog for NCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR2 Gene

ENSEMBL:
Gene Tree for NCR2 (if available)
TreeFam:
Gene Tree for NCR2 (if available)

Paralogs for NCR2 Gene

Paralogs for NCR2 Gene

Selected SIMAP similar genes for NCR2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NCR2 Gene

genes like me logo Genes that share paralogs with NCR2: view

Variants for NCR2 Gene

Sequence variations from dbSNP and Humsavar for NCR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs582880 -- 41,348,965(+) CACGC(A/C)CCCTT intron-variant
rs592292 -- 41,338,491(+) CTGTC(A/G)TTGCA intron-variant
rs603181 -- 41,338,622(+) ATACA(C/G)AATTC intron-variant
rs604542 -- 41,338,942(+) GTCTA(A/G)AGCTT intron-variant
rs606685 -- 41,339,395(+) ATTGT(G/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCR2 Gene

Variant ID Type Subtype PubMed ID
dgv6836n71 CNV Gain 21882294

Relevant External Links for NCR2 Gene

HapMap Linkage Disequilibrium report
NCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR2 Gene

Disorders for NCR2 Gene

(1) University of Copenhagen DISEASES for NCR2 Gene

(2) Novoseek inferred disease relationships for NCR2 Gene

Disease -log(P) Hits PubMed IDs
virus infection 31.3 1
tumors 31.2 6

Relevant External Links for NCR2

Genetic Association Database (GAD)
NCR2
Human Genome Epidemiology (HuGE) Navigator
NCR2
genes like me logo Genes that share disorders with NCR2: view

No data available for UniProtKB/Swiss-Prot for NCR2 Gene

Publications for NCR2 Gene

  1. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. (PMID: 10049942) Cantoni C. … Biassoni R. (J. Exp. Med. 1999) 2 3 4 23
  2. NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. (PMID: 14707061) Campbell K.S. … Catina T.L. (J. Immunol. 2004) 3 23
  3. Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. (PMID: 15728472) Poggi A. … Zocchi M.R. (J. Immunol. 2005) 3 23
  4. Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. (PMID: 15941912) Fuchs A. … Colonna M. (Blood 2005) 3 23
  5. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. (PMID: 18092004) Byrd A. … Watzl C. (PLoS ONE 2007) 3 23

Products for NCR2 Gene

Sources for NCR2 Gene

Back to Top

Content