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Aliases for NCR2 Gene

Aliases for NCR2 Gene

  • Natural Cytotoxicity Triggering Receptor 2 2 3 5
  • Lymphocyte Antigen 95 (Activating NK-Receptor; NK-P44) 2 3
  • Natural Killer Cell P44-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P44 3 4
  • NKP44 3 4
  • LY95 3 4
  • Lymphocyte Antigen 95 Homolog (Activating NK-Receptor; NK-P44) 3
  • NK Cell Activating Receptor (NKp44) 3
  • Lymphocyte Antigen 95 Homolog 4
  • CD336 Antigen 4
  • DJ149M18.1 3
  • CD336 3

External Ids for NCR2 Gene

Previous HGNC Symbols for NCR2 Gene

  • LY95

Previous GeneCards Identifiers for NCR2 Gene

  • GC06P041299
  • GC06P041350
  • GC06P041411
  • GC06P041022

Summaries for NCR2 Gene

GeneCards Summary for NCR2 Gene

NCR2 (Natural Cytotoxicity Triggering Receptor 2) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TREML4.

UniProtKB/Swiss-Prot for NCR2 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR2 Gene

Genomics for NCR2 Gene

Regulatory Elements for NCR2 Gene

Enhancers for NCR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041298 0.6 Ensembl ENCODE 11 -36.4 -36418 1.7 HDGF TARDBP TCF7 NBN JUNB ETV6 TBX21 CREM NCR2 TREM1 RNU6-643P
GH06F041222 0.5 Ensembl 10.5 -113.0 -112955 0.6 CBX1 CBX3 CBX5 TRIM24 TREML4 TREML2 TREML1 NCR2 LOC105375055
GH06F041332 1.4 FANTOM5 Ensembl ENCODE 0.8 -1.6 -1555 3.0 CTCF ZNF146 PKNOX1 TBL1XR1 MAX BMI1 EBF1 RAD21 ZIC2 ZBTB40 TFEB NCR2 RPL32P15
GH06F041318 1.3 FANTOM5 Ensembl ENCODE 0.3 -15.8 -15846 2.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B DMAP1 ZNF2 SLC30A9 ZNF207 ENSG00000226454 LOC101929535 RNU6-250P TREM1 ADCY10P1 TREML3P TREML4 NFYA TFEB RPL32P15
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NCR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NCR2 gene promoter:

Genomic Location for NCR2 Gene

Chromosome:
6
Start:
41,335,655 bp from pter
End:
41,350,887 bp from pter
Size:
15,233 bases
Orientation:
Plus strand

Genomic View for NCR2 Gene

Genes around NCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCR2 Gene

Proteins for NCR2 Gene

  • Protein details for NCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95944-NCTR2_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 2
    Protein Accession:
    O95944
    Secondary Accessions:
    • Q9H562
    • Q9H563
    • Q9H564
    • Q9UMT1
    • Q9UMT2

    Protein attributes for NCR2 Gene

    Size:
    276 amino acids
    Molecular mass:
    30677 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

    Three dimensional structures from OCA and Proteopedia for NCR2 Gene

    Alternative splice isoforms for NCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCR2 Gene

Post-translational modifications for NCR2 Gene

  • Glycosylation at Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for NCR2 Gene

Antibody Products

  • Abcam antibodies for NCR2

No data available for DME Specific Peptides for NCR2 Gene

Domains & Families for NCR2 Gene

Gene Families for NCR2 Gene

Protein Domains for NCR2 Gene

Suggested Antigen Peptide Sequences for NCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95944

UniProtKB/Swiss-Prot:

NCTR2_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR2: view

Function for NCR2 Gene

Molecular function for NCR2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10049942
genes like me logo Genes that share ontologies with NCR2: view

Phenotypes for NCR2 Gene

genes like me logo Genes that share phenotypes with NCR2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR2 Gene

Localization for NCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR2 Gene COMPARTMENTS Subcellular localization image for NCR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 10049942
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCR2: view

Pathways & Interactions for NCR2 Gene

genes like me logo Genes that share pathways with NCR2: view

Interacting Proteins for NCR2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362181%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000362181 O95944-NCTR2_HUMAN for NCR2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 10049942
GO:0007165 signal transduction TAS 10049942
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR2: view

No data available for SIGNOR curated interactions for NCR2 Gene

Drugs & Compounds for NCR2 Gene

(1) Drugs for NCR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NCR2: view

Transcripts for NCR2 Gene

mRNA/cDNA for NCR2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCR2 Gene

Natural cytotoxicity triggering receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for NCR2 Gene

GeneLoc Exon Structure for
NCR2
ECgene alternative splicing isoforms for
NCR2

Expression for NCR2 Gene

mRNA expression in normal human tissues for NCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of NCR2 Gene:

NCR2

SOURCE GeneReport for Unigene cluster for NCR2 Gene:

Hs.194721

mRNA Expression by UniProt/SwissProt for NCR2 Gene:

O95944-NCTR2_HUMAN
Tissue specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
genes like me logo Genes that share expression patterns with NCR2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NCR2 Gene

Orthologs for NCR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NCR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR2 34 35
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia NCR2 34 35
  • 76.52 (n)
mouse
(Mus musculus)
Mammalia B430306N03Rik 35
  • 19 (a)
ManyToMany
Species where no ortholog for NCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR2 Gene

ENSEMBL:
Gene Tree for NCR2 (if available)
TreeFam:
Gene Tree for NCR2 (if available)

Paralogs for NCR2 Gene

Paralogs for NCR2 Gene

(1) SIMAP similar genes for NCR2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NCR2 Gene

genes like me logo Genes that share paralogs with NCR2: view

Variants for NCR2 Gene

Sequence variations from dbSNP and Humsavar for NCR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10947963 -- 41,338,238(+) aacat(A/G)ctcaa intron-variant
rs10947964 -- 41,344,083(+) CTAAC(A/G)GGGGG intron-variant
rs10947965 -- 41,349,197(+) attat(C/T)atgta intron-variant
rs111244662 -- 41,336,508(+) CAATC(A/G)TGGAA intron-variant
rs111387617 -- 41,336,638(+) GGGCC(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCR2 Gene

Variant ID Type Subtype PubMed ID
esv3608790 CNV gain 21293372

Variation tolerance for NCR2 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR2 Gene

Disorders for NCR2 Gene

Relevant External Links for NCR2

Genetic Association Database (GAD)
NCR2
Human Genome Epidemiology (HuGE) Navigator
NCR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR2

No disorders were found for NCR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCR2 Gene

Publications for NCR2 Gene

  1. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. (PMID: 10049942) Cantoni C. … Biassoni R. (J. Exp. Med. 1999) 2 3 4 22 64
  2. Identification of a cellular ligand for the natural cytotoxicity receptor NKp44. (PMID: 23958951) Baychelier F. … Vieillard V. (Blood 2013) 3 4 64
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
  4. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y. … Lin Q. (Fertil. Steril. 2008) 3 22 64
  5. Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44. (PMID: 18092004) Byrd A. … Watzl C. (PLoS ONE 2007) 3 22 64

Products for NCR2 Gene

Sources for NCR2 Gene

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