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Aliases for NCR1 Gene

Aliases for NCR1 Gene

  • Natural Cytotoxicity Triggering Receptor 1 2 3
  • Natural Killer Cell P46-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P46 3 4
  • NKP46 3 4
  • LY94 3 4
  • Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46) 2
  • Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46) 3
  • Lymphocyte Antigen 94 Homolog 4
  • CD335 Antigen 4
  • HNKp46 4
  • CD335 3

External Ids for NCR1 Gene

Previous HGNC Symbols for NCR1 Gene

  • LY94

Previous GeneCards Identifiers for NCR1 Gene

  • GC19P055842
  • GC19P060093
  • GC19P060008
  • GC19P060109
  • GC19P055417
  • GC19P051740
  • GC19P054906

Summaries for NCR1 Gene

GeneCards Summary for NCR1 Gene

NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for NCR1 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR1 Gene

Genomics for NCR1 Gene

Regulatory Elements for NCR1 Gene

Genomic Location for NCR1 Gene

Chromosome:
19
Start:
54,905,992 bp from pter
End:
54,938,208 bp from pter
Size:
32,217 bases
Orientation:
Plus strand

Genomic View for NCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR1 Gene

  • Protein details for NCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76036-NCTR1_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 1
    Protein Accession:
    O76036
    Secondary Accessions:
    • B0V3L2
    • B0V3L3
    • B0V3L4
    • B0V3L5
    • B8JL03
    • O76016
    • O76017
    • O76018

    Protein attributes for NCR1 Gene

    Size:
    304 amino acids
    Molecular mass:
    34481 Da
    Quaternary structure:
    • Interacts with CD247 and FCER1G.

    Three dimensional structures from OCA and Proteopedia for NCR1 Gene

    Alternative splice isoforms for NCR1 Gene

neXtProt entry for NCR1 Gene

Proteomics data for NCR1 Gene at MOPED

Post-translational modifications for NCR1 Gene

Antibody Products

No data available for DME Specific Peptides for NCR1 Gene

Domains & Families for NCR1 Gene

Gene Families for NCR1 Gene

Protein Domains for NCR1 Gene

Graphical View of Domain Structure for InterPro Entry

O76036

UniProtKB/Swiss-Prot:

NCTR1_HUMAN :
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR1: view

Function for NCR1 Gene

Molecular function for NCR1 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 9730896
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NCR1: view
genes like me logo Genes that share phenotypes with NCR1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCR1 Gene

Localization for NCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR1 Gene COMPARTMENTS Subcellular localization image for NCR1 gene
Compartment Confidence
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9730896
GO:0016514 SWI/SNF complex ISS --
genes like me logo Genes that share ontologies with NCR1: view

Pathways & Interactions for NCR1 Gene

genes like me logo Genes that share pathways with NCR1: view

Pathways by source for NCR1 Gene

Interacting Proteins for NCR1 Gene

Gene Ontology (GO) - Biological Process for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9730896
GO:0007165 signal transduction TAS 9730896
GO:0030101 natural killer cell activation NAS 9730896
GO:0035556 intracellular signal transduction TAS 9730896
GO:0042269 regulation of natural killer cell mediated cytotoxicity TAS 15654827
genes like me logo Genes that share ontologies with NCR1: view

No data available for SIGNOR curated interactions for NCR1 Gene

Drugs & Compounds for NCR1 Gene

No Compound Related Data Available

Transcripts for NCR1 Gene

Unigene Clusters for NCR1 Gene

Natural cytotoxicity triggering receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -
SP7: -

Relevant External Links for NCR1 Gene

GeneLoc Exon Structure for
NCR1
ECgene alternative splicing isoforms for
NCR1

Expression for NCR1 Gene

mRNA expression in normal human tissues for NCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR1 Gene

This gene is overexpressed in Whole Blood (x35.1) and Spleen (x8.1).

SOURCE GeneReport for Unigene cluster for NCR1 Gene Hs.97084

mRNA Expression by UniProt/SwissProt for NCR1 Gene

O76036-NCTR1_HUMAN
Tissue specificity: Selectively expressed by both resting and activated NK cells.
genes like me logo Genes that share expression patterns with NCR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NCR1 Gene

Orthologs for NCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCR1 35
  • 74.13 (n)
  • 62.59 (a)
NCR1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCR1 35
  • 77.7 (n)
  • 63.91 (a)
NCR1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncr1 35
  • 72.3 (n)
  • 61.59 (a)
Ncr1 16
Ncr1 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCR1 35
  • 99.12 (n)
  • 98.03 (a)
NCR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncr1 35
  • 74.11 (n)
  • 64 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
OneToMany
Species with no ortholog for NCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR1 Gene

ENSEMBL:
Gene Tree for NCR1 (if available)
TreeFam:
Gene Tree for NCR1 (if available)

Paralogs for NCR1 Gene

Pseudogenes.org Pseudogenes for NCR1 Gene

genes like me logo Genes that share paralogs with NCR1: view

Variants for NCR1 Gene

Sequence variations from dbSNP and Humsavar for NCR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs269917 -- 54,916,142(+) gctat(A/G)tgtgt intron-variant
rs592878 -- 54,920,022(+) CTACC(A/G)GCTAA intron-variant
rs686815 -- 54,919,206(+) gaaat(A/C)aagac intron-variant
rs687182 -- 54,919,244(+) agctg(A/C/G)gcccg intron-variant
rs775835 -- 54,915,412(+) ATGCC(A/G)GTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCR1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
dgv1127e1 CNV Complex 17122850
nsv520644 CNV Loss 19592680
nsv833880 CNV Loss 17160897

Variation tolerance for NCR1 Gene

Residual Variation Intolerance Score: 75.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR1 Gene

HapMap Linkage Disequilibrium report
NCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR1 Gene

Disorders for NCR1 Gene

Relevant External Links for NCR1

Human Genome Epidemiology (HuGE) Navigator
NCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR1
genes like me logo Genes that share disorders with NCR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCR1 Gene

Publications for NCR1 Gene

  1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PMID: 9730896) Pessino A. … Moretta A. (J. Exp. Med. 1998) 2 23 67
  2. Identification of the amino acid sequence motif for conventional PKC-mediated regulation of NKp46 surface expression. (PMID: 20500693) Kim H.R. … Kim J. (Scand. J. Immunol. 2010) 23 67
  3. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. (PMID: 20008290) Carbone T. … Cavani A. (J. Immunol. 2010) 23 67
  4. The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells. (PMID: 20164429) Betser-Cohen G. … Mandelboim O. (J. Immunol. 2010) 23 67
  5. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. (PMID: 19949088) Zou Y. … Ning Q. (J. Immunol. 2010) 23 67

Products for NCR1 Gene

Sources for NCR1 Gene

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