NCR1 Gene

Aliases
for NCR1 gene

Previous GC identifers: GC19P055842 GC19P060093 GC19P060008 GC19P060109 GC19P051740

Summaries
for NCR1 gene

Genomic Views
for NCR1 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: NCR1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCR1

NCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055417:  view genomic region     (about GC identifiers)

Proteins
for NCR1 gene

2 PDB 3D structures from and Proteopedia for NCR1:

1OLL (3D)        1P6F (3D)    

Explore the universe of human proteins at neXtProt for NCR1: NX_O76036

Post-translational modifications:

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	R&D Systems Recombinant & Natural Proteins for NCR1 (NKp46/NCR1)
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	Novus Biologicals NCR1 Proteins Novus Biologicals NCR1 Lysates
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	ProSpec Recombinant Protein for NCR1
	Uscn Proteins for NCR1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	Novus Biologicals NCR1 Antibodies
	Abcam antibodies for NCR1
	Uscn Antibodies for NCR1
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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for NCR1 (NKp46/NCR1)
	GenScript Custom Assay Services for NCR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NCR1

Protein Domains /
Families
for NCR1 gene

ProtoNet protein and cluster: O76036

Function
for NCR1 gene

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Ncr1)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NCR1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCR1
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		SwitchGear 3'UTR luciferase reporter plasmid: NCR1 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCR1 (see all 7) OriGene shRNA RFP: NCR1 OriGene siRNA: NCR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCR1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NCR1

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			Sirion Biotech Customized adenovirus for overexpression of NCR1  Sirion Biotech Customized adenovirus for potent knockdown of NCR1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCR1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCR1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NCR1 (NM_004829)
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		Sirion Biotech Customized stable knockdown cell line services for NCR1  Sirion Biotech Customized inducible knockdown cell line services for NCR1 Sirion Biotech Customized stable overexpressing cell line services for NCR1 Sirion Biotech Customized inducible overexpressing cell line services for NCR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR1

Pathways & Interactions
for NCR1 gene

	Super-pathway	contained gene-specific pathways
1	Natural killer cell mediated cytotoxicity	Natural killer cell mediated cytotoxicity 1.00

1         Kegg Pathway  (Kegg details for NCR1)

Natural killer cell mediated cytotoxicity

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for NCR1 gene

Transcripts
for NCR1 gene

Expression
for NCR1 gene

NCR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAATTTCT

About this image

NCR1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	Natural killer-like cells (Derivation of hemato...)
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCR1

Orthologs
for NCR1 gene

Paralogs
for NCR1 gene

Paralogs for NCR1 gene

KIR2DL4²  LILRB4²  LILRB1²  LILRA6²  IGSF1²  LILRA5²  KIR3DL1²  OSCAR²  

LILRA4²  ENSG00000217792²  TARM1²  KIR3DX1²  LILRA3²  LILRB5²  LILRA1²  KIR3DL3²  

KIR2DL1²  A1BG²  LILRB2²  KIR2DL2²  LILRA2²  KIR3DL2²  KIR2DL3²  FCAR²  

LILRB3²  GP6²  

15 SIMAP similar genes for NCR1 using alignment to 2 protein entries:     NCTR1_HUMAN (see all proteins):

LILRB3    LILRA4    LILRA6    MIR cl-10    LILRB4    KIR3DL1

LILRA2    LILRB2    LILRA3    LILRA5    LILRB1    FLJ00275

LILRB5    GP6    LAIR2

NCR1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for NCR1
PGOHUM00000244363

Genomic Variants
for NCR1 gene

10/212 NCBI SNPs in NCR1 are shown (see all 212)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1431680821,2		--	55415591(+)	TGAAAC/TATTAT	5	--	us2k1		0	--	--	--	--
rs48064601,2	C,F,A,H	--	55415616(+)	AGAAGA/TTAGTG	5	--	us2k1		14		NS EA NA WA CSA	791
rs1851317561,2		--	55415620(+)	GTTAGG/TGTTAT	5	--	us2k1		0	--	--	--	--
rs48066151,2	C,A,H	--	55415668(+)	ATATGT/CATACT	5	--	us2k1		4		NS WA EA	478
rs48066161,2	F,A	--	55415671(+)	TGTATA/GCTGTA	5	--	us2k1		3		WA NA EA	358
rs1461707801,2		--	55415837(+)	CCCAAA/TGTTTA	5	--	us2k1		0	--	--	--	--
rs1392149451,2		--	55415871(+)	CATGTA/GGTATT	5	--	us2k1		0	--	--	--	--
rs2000422941,2		--	55415893(+)	CTTTT-/CTTTTT	5	--	us2k1		0	--	--	--	--
rs75082381,2	A	--	55415894(+)	cttttC/Tttttt	5	--	us2k1 trp3		0	--	--	--	--
rs1440273271,2		--	55415946(+)	AGTACA/TATGGC	5	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for NCR1 (55417508 - 55424439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NCR1
     2 CNVs: 4088 3200

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCR1

DNA2.0 Custom Variant and Variant Library Synthesis for NCR1

Disorders / Diseases
for NCR1 gene

20/21 diseases for NCR1

5 Novoseek disease relationships for NCR1 gene    About this table

Publications
for NCR1 gene

PubMed articles for NCR1 gene, integrated from 9 sources (see all 120): (articles sorted by number of sources associating them with NCR1)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PubMed id 9730896)^{1, 2, 3, 9} Pessino A.... Moretta A. (1998)
2. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. (PubMed id 12960161)^{1, 2, 9} Foster C.E.... Sun P.D. (2003)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Structure of the human NK cell triggering receptor NKp46 ectodomain. (PubMed id 12951052)^{1, 2} Ponassi M.... Bordo D. (2003)
5. Human natural killer cell receptors: insights into their molecular function and structure. (PubMed id 14754506)^{1, 2} Biassoni R.... Dimasi N. (2003)
6. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. (PubMed id 14504081)^{1, 9} Arnon T.I....Mandelboim O. (2004)
7. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PubMed id 18023431)^{1, 9} Zhang Y....Lin Q. (2008)
8. Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30). (PubMed id 15654827)^{1, 9} Mavoungou E....Kremsner P.G. (2005)
9. CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity. (PubMed id 14635045)^{1, 9} Marcenaro E....Moretta A. (2003)
10. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. (PubMed id 17875681)^{1, 9} El-Sherbiny Y.M....Cook G.P. (2007)

External Searches for NCR1 gene

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Products
for NCR1 gene