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Aliases for NCR1 Gene

Aliases for NCR1 Gene

  • Natural Cytotoxicity Triggering Receptor 1 2 3 5
  • Natural Killer Cell P46-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P46 3 4
  • NKP46 3 4
  • LY94 3 4
  • Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46) 2
  • Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46) 3
  • Lymphocyte Antigen 94 Homolog 4
  • CD335 Antigen 4
  • HNKp46 4
  • CD335 3

External Ids for NCR1 Gene

Previous HGNC Symbols for NCR1 Gene

  • LY94

Previous GeneCards Identifiers for NCR1 Gene

  • GC19P055842
  • GC19P060093
  • GC19P060008
  • GC19P060109
  • GC19P055417
  • GC19P051740
  • GC19P054906
  • GC19P054907
  • GC19P054921
  • GC19P054939
  • GC19P054964

Summaries for NCR1 Gene

GeneCards Summary for NCR1 Gene

NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Diseases associated with NCR1 include Viral Infectious Disease. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include signal transducer activity, downstream of receptor. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot for NCR1 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR1 Gene

Genomics for NCR1 Gene

Regulatory Elements for NCR1 Gene

Enhancers for NCR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055337 1.8 FANTOM5 ENCODE dbSUPER 8.8 +433.8 433836 4.0 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC LENG8-AS1 ENSG00000235681 U2AF2 FAM71E2 KMT5C PPP6R1 ZNF628 TMEM238 IL11 TMEM190
GH19G054905 1.2 Ensembl ENCODE 9.6 +0.1 63 2.0 ARID4B GLI4 ZNF2 TCF12 CBX5 ZNF143 FOS KLF7 DEK ZNF263 NCR1 KIR3DL2 ENSG00000275012
GH19G054893 0.5 ENCODE 8.3 -12.2 -12205 1.3 JUND TEAD4 TCF7L2 RBFOX2 KIR2DS4 EPS8L1 RDH13 NCR1 KIR3DL2 ENSG00000268734 PIR47082
GH19G055275 1.2 FANTOM5 Ensembl ENCODE 3 +370.8 370825 2.2 MTA2 BHLHE40 SIN3A CEBPB DPF2 ZNF623 TBX21 ARID3A NFYB SPI1 HSPBP1 KIR3DL2 KIR2DS4 ZNF628 NCR1 EPN1 PPP6R1 KMT5C KIR3DL1 GC19M055263
GH19G055111 1.8 FANTOM5 ENCODE dbSUPER 1.4 +209.4 209391 8.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 EPS8L1 RDH13 TNNT1 RPL28 TMEM238 PPP1R12C ZNF865 SHISA7 PPP6R1 FCAR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCR1 Gene

Chromosome:
19
Start:
54,905,992 bp from pter
End:
54,938,208 bp from pter
Size:
32,217 bases
Orientation:
Plus strand

Genomic View for NCR1 Gene

Genes around NCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NCR1 Gene

  • Protein details for NCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76036-NCTR1_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 1
    Protein Accession:
    O76036
    Secondary Accessions:
    • B0V3L2
    • B0V3L3
    • B0V3L4
    • B0V3L5
    • B8JL03
    • O76016
    • O76017
    • O76018

    Protein attributes for NCR1 Gene

    Size:
    304 amino acids
    Molecular mass:
    34481 Da
    Quaternary structure:
    • Interacts with CD247 and FCER1G.

    Three dimensional structures from OCA and Proteopedia for NCR1 Gene

    Alternative splice isoforms for NCR1 Gene

neXtProt entry for NCR1 Gene

Post-translational modifications for NCR1 Gene

Antibody Products

  • Abcam antibodies for NCR1

No data available for DME Specific Peptides for NCR1 Gene

Domains & Families for NCR1 Gene

Protein Domains for NCR1 Gene

Graphical View of Domain Structure for InterPro Entry

O76036

UniProtKB/Swiss-Prot:

NCTR1_HUMAN :
  • Belongs to the natural cytotoxicity receptor (NCR) family.
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.
genes like me logo Genes that share domains with NCR1: view

Function for NCR1 Gene

Molecular function for NCR1 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor TAS 9730896
genes like me logo Genes that share ontologies with NCR1: view
genes like me logo Genes that share phenotypes with NCR1: view

Animal Models for NCR1 Gene

MGI Knock Outs for NCR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCR1

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NCR1 Gene

Localization for NCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCR1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
lysosome 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9730896
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016514 SWI/SNF complex ISS --
genes like me logo Genes that share ontologies with NCR1: view

Pathways & Interactions for NCR1 Gene

genes like me logo Genes that share pathways with NCR1: view

Gene Ontology (GO) - Biological Process for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9730896
GO:0007165 signal transduction TAS 9730896
GO:0030101 natural killer cell activation NAS 9730896
GO:0042269 regulation of natural killer cell mediated cytotoxicity TAS 15654827
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NCR1: view

No data available for SIGNOR curated interactions for NCR1 Gene

Drugs & Compounds for NCR1 Gene

No Compound Related Data Available

Transcripts for NCR1 Gene

Unigene Clusters for NCR1 Gene

Natural cytotoxicity triggering receptor 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NCR1

Alternative Splicing Database (ASD) splice patterns (SP) for NCR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -
SP7: -

Relevant External Links for NCR1 Gene

GeneLoc Exon Structure for
NCR1
ECgene alternative splicing isoforms for
NCR1

Expression for NCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR1 Gene

This gene is overexpressed in Whole Blood (x35.1) and Spleen (x8.1).

NURSA nuclear receptor signaling pathways regulating expression of NCR1 Gene:

NCR1

SOURCE GeneReport for Unigene cluster for NCR1 Gene:

Hs.97084

mRNA Expression by UniProt/SwissProt for NCR1 Gene:

O76036-NCTR1_HUMAN
Tissue specificity: Selectively expressed by both resting and activated NK cells.

Evidence on tissue expression from TISSUES for NCR1 Gene

  • Blood(4.5)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with NCR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCR1 Gene

Orthologs for NCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR1 35 34
  • 99.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCR1 35 34
  • 77.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCR1 35 34
  • 74.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncr1 34
  • 74.11 (n)
mouse
(Mus musculus)
Mammalia Ncr1 34 16 35
  • 72.3 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 11 (a)
OneToMany
Species where no ortholog for NCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR1 Gene

ENSEMBL:
Gene Tree for NCR1 (if available)
TreeFam:
Gene Tree for NCR1 (if available)

Paralogs for NCR1 Gene

Variants for NCR1 Gene

Sequence variations from dbSNP and Humsavar for NCR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035527 A colorectal cancer sample
rs2278428 --

Structural Variations from Database of Genomic Variants (DGV) for NCR1 Gene

Variant ID Type Subtype PubMed ID
dgv1819n106 OTHER inversion 24896259
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3893250 CNV loss 25118596
nsv1079034 OTHER inversion 25765185
nsv1150276 OTHER inversion 26484159
nsv428372 CNV gain+loss 18775914
nsv520644 CNV loss 19592680
nsv833880 CNV loss 17160897

Variation tolerance for NCR1 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCR1 Gene

Disorders for NCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
viral infectious disease
  • viral disease
- elite association - COSMIC cancer census association via MalaCards
Search NCR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCR1

Human Genome Epidemiology (HuGE) Navigator
NCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCR1
genes like me logo Genes that share disorders with NCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCR1 Gene

Publications for NCR1 Gene

  1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PMID: 9730896) Pessino A. … Moretta A. (J. Exp. Med. 1998) 2 3 4 22 64
  2. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. (PMID: 12960161) Foster C.E. … Sun P.D. (J. Biol. Chem. 2003) 3 4 22 64
  3. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PMID: 18023431) Zhang Y. … Lin Q. (Fertil. Steril. 2008) 3 22 64
  4. Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels. (PMID: 18275895) Boyiadzis M. … Hakim F.T. (Biol. Blood Marrow Transplant. 2008) 3 22 64
  5. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. (PMID: 17875681) El-Sherbiny Y.M. … Cook G.P. (Cancer Res. 2007) 3 22 64

Products for NCR1 Gene

Sources for NCR1 Gene

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