Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCR1 Gene

Aliases for NCR1 Gene

  • Natural Cytotoxicity Triggering Receptor 1 2 3
  • NKP46 3 4 6
  • LY94 3 4 6
  • Natural Killer Cell P46-Related Protein 3 4
  • NK Cell-Activating Receptor 3 4
  • NK-P46 3 4
  • Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46) 2
  • Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46) 3
  • Lymphocyte Antigen 94 Homolog 4
  • CD335 Antigen 4
  • HNKp46 4
  • CD335 3

External Ids for NCR1 Gene

Previous Symbols for NCR1 Gene

  • LY94

Summaries for NCR1 Gene

GeneCards Summary for NCR1 Gene

NCR1 (Natural Cytotoxicity Triggering Receptor 1) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for NCR1 Gene

  • Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Wiki entry for NCR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCR1 Gene

Genomics for NCR1 Gene

Genomic Location for NCR1 Gene

Start:
54,906,150 bp from pter
End:
54,916,140 bp from pter
Size:
9,991 bases
Orientation:
Plus strand

Genomic View for NCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for NCR1 Gene

Proteins for NCR1 Gene

  • Protein details for NCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76036-NCTR1_HUMAN
    Recommended name:
    Natural cytotoxicity triggering receptor 1
    Protein Accession:
    O76036
    Secondary Accessions:
    • B0V3L2
    • B0V3L3
    • B0V3L4
    • B0V3L5
    • B8JL03
    • O76016
    • O76017
    • O76018

    Protein attributes for NCR1 Gene

    Size:
    304 amino acids
    Molecular mass:
    34481 Da
    Quaternary structure:
    • Interacts with CD247 and FCER1G.

    Three dimensional structures from OCA and Proteopedia for NCR1 Gene

    Alternative splice isoforms for NCR1 Gene

neXtProt entry for NCR1 Gene

Proteomics data for NCR1 Gene at MOPED

Post-translational modifications for NCR1 Gene

No data available for DME Specific Peptides for NCR1 Gene

Domains for NCR1 Gene

Gene Families for NCR1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for NCR1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NCTR1_HUMAN
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.:
    • O76036
Family:
  • Belongs to the natural cytotoxicity receptor (NCR) family.:
    • O76036
genes like me logo Genes that share domains with NCR1: view

Function for NCR1 Gene

Molecular function for NCR1 Gene

UniProtKB/Swiss-Prot Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Gene Ontology (GO) - Molecular Function for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 9730896
genes like me logo Genes that share ontologies with NCR1: view

Phenotypes for NCR1 Gene

genes like me logo Genes that share phenotypes with NCR1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCR1 Gene

Localization for NCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCR1 Gene COMPARTMENTS Subcellular localization image for NCR1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 9730896
GO:0016514 SWI/SNF complex ISS --
genes like me logo Genes that share ontologies with NCR1: view

Pathways for NCR1 Gene

genes like me logo Genes that share pathways with NCR1: view

Pathways by source for NCR1 Gene

1 KEGG pathway for NCR1 Gene

Interacting Proteins for NCR1 Gene

Gene Ontology (GO) - Biological Process for NCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9730896
GO:0007165 signal transduction TAS 9730896
GO:0030101 natural killer cell activation NAS 9730896
GO:0035556 intracellular signal transduction TAS 9730896
GO:0042269 regulation of natural killer cell mediated cytotoxicity TAS 15654827
genes like me logo Genes that share ontologies with NCR1: view

Transcripts for NCR1 Gene

Unigene Clusters for NCR1 Gene

Natural cytotoxicity triggering receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -
SP7: -

Relevant External Links for NCR1 Gene

GeneLoc Exon Structure for
NCR1
ECgene alternative splicing isoforms for
NCR1

Expression for NCR1 Gene

mRNA expression in normal human tissues for NCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCR1 Gene

This gene is overexpressed in Whole Blood (35.1) and Spleen (8.1).

SOURCE GeneReport for Unigene cluster for NCR1 Gene Hs.97084

mRNA Expression by UniProt/SwissProt for NCR1 Gene

O76036-NCTR1_HUMAN
Tissue specificity: Selectively expressed by both resting and activated NK cells.
genes like me logo Genes that share expressions with NCR1: view

Orthologs for NCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCR1 36
  • 99.12 (n)
  • 98.03 (a)
NCR1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCR1 36
  • 74.13 (n)
  • 62.59 (a)
NCR1 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCR1 36
  • 77.7 (n)
  • 63.91 (a)
NCR1 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncr1 36
  • 72.3 (n)
  • 61.59 (a)
Ncr1 16
Ncr1 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncr1 36
  • 74.11 (n)
  • 64 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 11 (a)
OneToMany
Species with no ortholog for NCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCR1 Gene

ENSEMBL:
Gene Tree for NCR1 (if available)
TreeFam:
Gene Tree for NCR1 (if available)

Paralogs for NCR1 Gene

Pseudogenes.org Pseudogenes for NCR1 Gene

genes like me logo Genes that share paralogs with NCR1: view

Variants for NCR1 Gene

Sequence variations from dbSNP and Humsavar for NCR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs269920 -- 54,910,099(+) CGAGC(A/G)ATCAG intron-variant
rs1433097 -- 54,907,100(+) TGGGC(C/T)AGGCG intron-variant
rs2240951 -- 54,911,525(-) gatcc(A/G)cccac intron-variant
rs2278427 -- 54,906,373(+) TCCGG(A/G)TTCAG intron-variant
rs2278428 - 54,906,696(+) AAGTC(A/C)AATTC missense, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCR1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
dgv1127e1 CNV Complex 17122850
nsv520644 CNV Loss 19592680
nsv833880 CNV Loss 17160897

Relevant External Links for NCR1 Gene

HapMap Linkage Disequilibrium report
NCR1

Disorders for NCR1 Gene

(1) University of Copenhagen DISEASES for NCR1 Gene

(5) Novoseek inferred disease relationships for NCR1 Gene

Disease -log(P) Hits PubMed IDs
virus infection 44.4 1
tumors 33.1 11
influenza 20.5 5
leukemia 0 2
tuberculosis 0 1

Relevant External Links for NCR1

Human Genome Epidemiology (HuGE) Navigator
NCR1
genes like me logo Genes that share disorders with NCR1: view

No data available for UniProtKB/Swiss-Prot for NCR1 Gene

Publications for NCR1 Gene

  1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PMID: 9730896) Pessino A. … Moretta A. (J. Exp. Med. 1998) 2 3 4 23
  2. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. (PMID: 12960161) Foster C.E. … Sun P.D. (J. Biol. Chem. 2003) 3 4 23
  3. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. (PMID: 14504081) Arnon T.I. … Mandelboim O. (Blood 2004) 3 23
  4. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. (PMID: 17875681) El-Sherbiny Y.M. … Cook G.P. (Cancer Res. 2007) 3 23
  5. Structure of the human NK cell triggering receptor NKp46 ectodomain. (PMID: 12951052) Ponassi M. … Bordo D. (Biochem. Biophys. Res. Commun. 2003) 3 4

Products for NCR1 Gene

Sources for NCR1 Gene

Back to Top

Content