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NCR1 Gene

protein-coding   GIFtS: 60
GCID: GC19P055417

Natural Cytotoxicity Triggering Receptor 1

(Previous name: lymphocyte antigen 94 (mouse) homolog (activating NK-receptor;...)
(Previous symbol: LY94)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natural Cytotoxicity Triggering Receptor 11 2     CD3352
LY941 2 3 5     Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46)2
Natural Killer Cell P46-Related Protein2 3     NKp463
NK-p462 3     CD335 Antigen3
NK Cell-Activating Receptor2 3     hNKp463
NKP462 5     Lymphocyte Antigen 94 Homolog3
Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)1     

External Ids:    HGNC: 67311   Entrez Gene: 94372   Ensembl: ENSG000001894307   OMIM: 6045305   UniProtKB: O760363   

Export aliases for NCR1 gene to outside databases

Previous GC identifers: GC19P055842 GC19P060093 GC19P060008 GC19P060109 GC19P051740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NCR1 Gene:
NCR1 (natural cytotoxicity triggering receptor 1) is a protein-coding gene. Diseases associated with NCR1 include cytomegalovirus infection, and hematopoietic stem cell transplantation. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: NCTR1_HUMAN, O76036
Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural
killer (NK) cells to mediate tumor cell lysis

Gene Wiki entry for NCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  NT_187671.1  NT_187674.1  NT_187675.1  NT_187676.1  NT_187677.1  
NT_187683.1  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCR1 gene promoter:
         AML1a   AREB6   CREB   PPAR-gamma1   Ik-2   deltaCREB   SEF-1 (1)   PPAR-gamma2   LyF-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCR1 promoter sequence
   Search Chromatin IP Primers for NCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

NCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055417:  view genomic region     (about GC identifiers)

Start:
55,417,508 bp from pter      End:
55,427,508 bp from pter
Size:
10,001 bases      Orientation:
plus strand

Selected alternative locations (see all 8):
Chr19+,NW_003571060 810,507-817,421      Chr19+,NW_003571061 618,300-625,231      Chr19+,NW_003571057 913,662-920,593     
Chr19+,NW_003571056 886,125-893,056      Chr19+,NW_003571058 888,211-895,142      Chr19+,NW_003571059 824,504-831,435     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NCTR1_HUMAN, O76036 (See protein sequence)
Recommended Name: Natural cytotoxicity triggering receptor 1 precursor  
Size: 304 amino acids; 34481 Da
Subunit: Interacts with CD247 and FCER1G
2 PDB 3D structures from and Proteopedia for NCR1:
1OLL (3D)        1P6F (3D)    
Secondary accessions: B0V3L2 B0V3L3 B0V3L4 B0V3L5 B8JL03 O76016 O76017 O76018
Alternative splicing: 6 isoforms:  O76036-1   O76036-2   O76036-3   O76036-4   O76036-5   O76036-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCR1: NX_O76036

Explore proteomics data for NCR1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • O-glycosylated1
  • Glycosylation2 at Asn216

  • See NCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138929.2  NP_001138930.2  NP_001229285.1  NP_001229286.1  NP_004820.2  

    ENSEMBL proteins: 
     ENSP00000291890   ENSP00000469750   ENSP00000471986   ENSP00000344358   ENSP00000339515  
     ENSP00000349972   ENSP00000404434  

    NCR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for NCR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O76036

    ProtoNet protein and cluster: O76036

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: NCTR1_HUMAN, O76036
    Similarity: Belongs to the natural cytotoxicity receptor (NCR) family
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    NCR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCTR1_HUMAN, O76036
    Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural
    killer (NK) cells to mediate tumor cell lysis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS9730896
         
    NCR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCR1:
     Decreased cell number and incr 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ncr1):
     hematopoietic system  immune system  mortality/aging  normal 

    NCR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCR1

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    GenScript: all cDNA clones in your preferred vector (see all 3): NCR1 (NM_004829)
    Sino Biological Human cDNA Clone for NCR1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCR1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCTR1_HUMAN, O76036: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol1
    extracellular1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS9730896
    GO:0016514SWI/SNF complex ISS--

    NCR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NCR1):
        Natural killer cell mediated cytotoxicity


    NCR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCR1
    Interactions:

        GeneGlobe Interaction Network for NCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for NCR1 (O760363 ENSP000002918904) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225553O431893, ENSP000003919014I2D: score=1 STRING: ENSP00000391901
    CD247P209633, ENSP000003547824I2D: score=3 STRING: ENSP00000354782
    CD59P139873, ENSP000003402104I2D: score=2 STRING: ENSP00000340210
    PHF1O431893I2D: score=1 
    FCER1GP302733, ENSP000002899024I2D: score=2 STRING: ENSP00000289902
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9730896
    GO:0007165signal transduction TAS9730896
    GO:0030101natural killer cell activation NAS9730896
    GO:0035556intracellular signal transduction TAS9730896
    GO:0042269regulation of natural killer cell mediated cytotoxicity TAS15654827

    NCR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCR1 (NCTR1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NCR1 gene (5 alternative transcripts): 
    NM_001145457.2  NM_001145458.2  NM_001242356.2  NM_001242357.2  NM_004829.6  

    Unigene Cluster for NCR1:

    Natural cytotoxicity triggering receptor 1
    Hs.97084  [show with all ESTs]
    Unigene Representative Sequence: BC064806
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291890(uc002qib.2) ENST00000601903 ENST00000601137 ENST00000598576
    ENST00000594765 ENST00000350790(uc002qid.2 uc002qif.2) ENST00000338835(uc002qie.2)
    ENST00000357397(uc010esj.2) ENST00000447255(uc002qic.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector (see all 3): NCR1 (NM_004829)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCR1
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      QuantiFast Probe-based Assays in human, mouse, rat NCR1

    Additional mRNA sequence: 

    AJ001383.1 AJ006121.1 AJ006122.1 AJ006123.1 AY346373.1 BC064806.1 

    4 DOTS entries:

    DT.104692  DT.102820954  DT.100772832  DT.92068520 

    15 AceView cDNA sequences:

    AJ006121 AJ006122 AW962934 BI909184 NM_004829 BC064806 AJ001383 AJ006123 
    AW962924 AY346373 AA371539 AA321018 AA371538 BI906800 BI912072 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCR1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                                                                  
    SP2:                                                                  
    SP3:              -     -                                             
    SP4:                                            -                     
    SP5:                    -                                             


    ECgene alternative splicing isoforms for NCR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAATTTCT
    NCR1 Expression
    About this image


    NCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells
             nk cells   
    NCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97084

    UniProtKB/Swiss-Prot: NCTR1_HUMAN, O76036
    Tissue specificity: Selectively expressed by both resting and activated NK cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCR1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncr11 , 5 natural cytotoxicity triggering receptor 11, 5 72.3(n)1
    61.59(a)1
      7 (2.50 cM)5
    170861  NM_010746.31  NP_034876.21 
     43377245 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    11(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for NCR1 (if available)
    TreeFam Gene Tree for NCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCR1 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for NCR1 using alignment to 2 protein entries:     NCTR1_HUMAN (see all proteins) (see all similar genes):
    KIR-G2    LILRA4    LILRB3    MIR cl-10    p140    LILRA6
    LILRB4    LILRA3    LILRA2    LILRB2    KIR-G1    LILRA5
    FLJ00275    KIR-K3    KIR-K36    KIR-K39    KIR-K61    KIR-K64

    NCR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NCR1
    PGOHUM00000244363


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCR1 (see all 284)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355274
    A colorectal cancer sample4--see VAR_0355272 D Y mis40--------
    rs1431680821,2
    C--55415591(+) TGAAAC/TATTAT 5 -- us2k10--------
    rs48064601,2
    C,F,A,H--55415616(+) AGAAGA/TTAGTG 5 -- us2k114Minor allele frequency- T:0.46NS EA NA WA CSA 791
    rs1851317561,2
    --55415620(+) GTTAGG/TGTTAT 5 -- us2k10--------
    rs48066151,2
    C,A,H--55415668(+) ATATGT/CATACT 5 -- us2k14Minor allele frequency- C:0.05NS WA EA 478
    rs48066161,2
    C,F,A--55415671(+) TGTATA/GCTGTA 5 -- us2k13Minor allele frequency- G:0.08WA NA EA 358
    rs1461707801,2
    --55415837(+) CCCAAA/TGTTTA 5 -- us2k10--------
    rs1392149451,2
    C--55415871(+) CATGTA/GGTATT 5 -- us2k10--------
    rs2000422941,2
    --55415893(+) CTTTT-/CTTTTT 5 -- us2k10--------
    rs75082381,2
    A--55415894(+) cttttC/Tttttt 5 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for NCR1 (55417508 - 55427508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718872CNV Deletion23290073
    nsv520644CNV Loss19592680
    nsv833880CNV Loss17160897
    nsv428372CNV Gain+Loss18775914
    dgv1126e1CNV Complex17122850
    dgv1127e1CNV Complex17122850
    dgv1119e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604530    OMIM disorders: --

    Selected diseases for NCR1 (see all 32):    
    About MalaCards
    cytomegalovirus infection    hematopoietic stem cell transplantation    vaccinia    influenza
    pregnancy loss    newcastle disease    mycosis fungoides    allergic contact dermatitis
    contact dermatitis    peritonitis    tuberculosis    hepatitis c virus
    acute myeloid leukemia    herpes simplex    crohn's disease    multiple myeloma
    breast and colorectal cancer    myeloma    hepatitis c    cervical cancer

    1 disease from the University of Copenhagen DISEASES database for NCR1:
    Influenza

    NCR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    5 Novoseek inferred disease relationships for NCR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 44.4 1 16474130 (1)
    tumors 33.1 12 9730896 (3), 14504081 (3), 11606250 (1), 15759080 (1) (see all 7)
    influenza 20.5 7 17312110 (3), 20147410 (2)
    leukemia 0 2 15654827 (1), 16940427 (1)
    tuberculosis 0 2 11907104 (1)

    Human Genome Epidemiology (HuGE) Navigator: NCR1 (1 document)

    Export disorders for NCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCR1 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with NCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. (PubMed id 9730896)1, 2, 3, 9 Pessino A.... Moretta A. (J. Exp. Med. 1998)
    2. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. (PubMed id 12960161)1, 2, 9 Foster C.E.... Sun P.D. (J. Biol. Chem. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Structure of the human NK cell triggering receptor NKp46 ectodomain. (PubMed id 12951052)1, 2 Ponassi M.... Bordo D. (Biochem. Biophys. Res. Commun. 2003)
    5. Human natural killer cell receptors: insights into their molecular function and structure. (PubMed id 14754506)1, 2 Biassoni R.... Dimasi N. (J. Cell. Mol. Med. 2003)
    6. The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. (PubMed id 14504081)1, 9 Arnon T.I....Mandelboim O. (Blood 2004)
    7. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. (PubMed id 18023431)1, 9 Zhang Y....Lin Q. (Fertil. Steril. 2008)
    8. Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30). (PubMed id 15654827)1, 9 Mavoungou E....Kremsner P.G. (Clin. Exp. Immunol. 2005)
    9. CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity. (PubMed id 14635045)1, 9 Marcenaro E....Moretta A. (Eur. J. Immunol. 2003)
    10. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. (PubMed id 17875681)1, 9 El-Sherbiny Y.M....Cook G.P. (Cancer Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9437 HGNC: 6731 AceView: NCR1 Ensembl:ENSG00000189430 euGenes: HUgn9437
    ECgene: NCR1 Kegg: 9437 H-InvDB: NCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCR1 gene:
    Search GeneIP for patents involving NCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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