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Aliases for NCOR2 Gene

Aliases for NCOR2 Gene

  • Nuclear Receptor Corepressor 2 2 3
  • SMRT 3 4 6
  • Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor 3 4
  • T3 Receptor-Associating Factor 3 4
  • CTG Repeat Protein 26 3 4
  • SMAP270 3 4
  • N-CoR2 3 4
  • CTG26 3 4
  • TRAC 3 4
  • Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor 4
  • Silencing Mediator For Retinoid And Thyroid Hormone Receptors 3
  • Nuclear Receptor Co-Repressor 2 2
  • SMRTE-Tau 3
  • TNRC14 3
  • TRAC-1 3
  • TRAC1 3
  • SMRTE 3

External Ids for NCOR2 Gene

Previous GeneCards Identifiers for NCOR2 Gene

  • GC12M123498
  • GC12M124551
  • GC12M123162
  • GC12M123333
  • GC12M124808
  • GC12M121771

Summaries for NCOR2 Gene

Entrez Gene Summary for NCOR2 Gene

  • This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

GeneCards Summary for NCOR2 Gene

NCOR2 (Nuclear Receptor Corepressor 2) is a Protein Coding gene. Diseases associated with NCOR2 include thyroid hormone resistance. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot for NCOR2 Gene

  • Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

Gene Wiki entry for NCOR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOR2 Gene

Genomics for NCOR2 Gene

Regulatory Elements for NCOR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCOR2 Gene

Start:
124,324,411 bp from pter
End:
124,567,589 bp from pter
Size:
243,179 bases
Orientation:
Minus strand

Genomic View for NCOR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOR2 Gene

Proteins for NCOR2 Gene

  • Protein details for NCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y618-NCOR2_HUMAN
    Recommended name:
    Nuclear receptor corepressor 2
    Protein Accession:
    Q9Y618
    Secondary Accessions:
    • O00613
    • O15416
    • O15421
    • Q13354
    • Q56D06
    • Q59GM0
    • Q9Y5U0

    Protein attributes for NCOR2 Gene

    Size:
    2525 amino acids
    Molecular mass:
    274804 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity).
    SequenceCaution:
    • Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794; Evidence={ECO:0000305}; Sequence=BAD92326.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR2 Gene

    Alternative splice isoforms for NCOR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR2 Gene

Proteomics data for NCOR2 Gene at MOPED

Post-translational modifications for NCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCOR2 Gene

Domains for NCOR2 Gene

Protein Domains for NCOR2 Gene

Suggested Antigen Peptide Sequences for NCOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y618

UniProtKB/Swiss-Prot:

NCOR2_HUMAN :
  • Q9Y618
Domain:
  • The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2)
  • The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity
  • Contains 2 SANT domains.
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR2: view

No data available for Gene Families for NCOR2 Gene

Function for NCOR2 Gene

Molecular function for NCOR2 Gene

GENATLAS Biochemistry: nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone receptors,ubiquitously expressed,recruiting the histone deacytylation complex Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling and repression of transcription
UniProtKB/Swiss-Prot Function: Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
UniProtKB/Swiss-Prot Induction: Regulated during cell cycle progression

Gene Ontology (GO) - Molecular Function for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001012 RNA polymerase II regulatory region DNA binding --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IMP 12628926
GO:0005112 Notch binding IPI 10713164
genes like me logo Genes that share ontologies with NCOR2: view
genes like me logo Genes that share phenotypes with NCOR2: view

Animal Models for NCOR2 Gene

MGI Knock Outs for NCOR2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NCOR2 Gene

Localization for NCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOR2 Gene COMPARTMENTS Subcellular localization image for NCOR2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex --
GO:0000785 chromatin --
GO:0005634 nucleus IDA 10097068
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NCOR2: view

Pathways for NCOR2 Gene

SuperPathways for NCOR2 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Signaling by NOTCH1 PEST Domain Mutants in Cancer
3 Immune response NFAT in immune response
4 Translocation of ZAP-70 to Immunological synapse
5 Notch signaling pathway (KEGG)
genes like me logo Genes that share pathways with NCOR2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0001701 in utero embryonic development --
GO:0003007 heart morphogenesis --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated TAS --
genes like me logo Genes that share ontologies with NCOR2: view

Compounds for NCOR2 Gene

(1) HMDB Compounds for NCOR2 Gene

Compound Synonyms Cas Number PubMed IDs
Retinoic acid
  • Retinoate
302-79-4

(21) Novoseek inferred chemical compound relationships for NCOR2 Gene

Compound -log(P) Hits PubMed IDs
retinoid 90.3 88
retinoic acid 77.1 52
steroid 59.5 27
estrogen 59.2 17
4-hydroxytamoxifen 58.8 7
genes like me logo Genes that share compounds with NCOR2: view

Transcripts for NCOR2 Gene

mRNA/cDNA for NCOR2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCOR2 Gene

Nuclear receptor corepressor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCOR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ·
SP1:
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SP8: -
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SP25:
SP26:

ExUns: 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c · 33d ^ 34a · 34b · 34c ^ 35 ^ 36a · 36b ^ 37 ^ 38a ·
SP1: - -
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SP17:
SP18:
SP19: -
SP20: - -
SP21: -
SP22:
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SP24:
SP25: -
SP26:

ExUns: 38b ^ 39 ^ 40a · 40b · 40c · 40d ^ 41a · 41b · 41c · 41d ^ 42a · 42b · 42c · 42d
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
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SP21:
SP22: -
SP23:
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SP26:

Relevant External Links for NCOR2 Gene

GeneLoc Exon Structure for
NCOR2
ECgene alternative splicing isoforms for
NCOR2

Expression for NCOR2 Gene

mRNA expression in normal human tissues for NCOR2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOR2 Gene

SOURCE GeneReport for Unigene cluster for NCOR2 Gene Hs.137510

mRNA Expression by UniProt/SwissProt for NCOR2 Gene

Q9Y618-NCOR2_HUMAN
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain
genes like me logo Genes that share expressions with NCOR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NCOR2 Gene

Orthologs for NCOR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOR2 35
  • 96.82 (n)
  • 96.84 (a)
NCOR2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCOR2 35
  • 89.11 (n)
  • 92.57 (a)
NCOR2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOR2 35
  • 88.66 (n)
  • 92.46 (a)
NCOR2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncor2 35
  • 83.97 (n)
  • 88.36 (a)
Ncor2 16
Ncor2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOR2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOR2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncor2 35
  • 84.21 (n)
  • 87.84 (a)
chicken
(Gallus gallus)
Aves NCOR2 35
  • 75.16 (n)
  • 76.19 (a)
NCOR2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOR2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncor2 35
  • 65.34 (n)
  • 66.38 (a)
zebrafish
(Danio rerio)
Actinopterygii ncor2 35
  • 61.06 (n)
  • 58.84 (a)
ncor2 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Smr 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gei-8 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNT1 36
  • 14 (a)
OneToMany
Species with no ortholog for NCOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCOR2 Gene

ENSEMBL:
Gene Tree for NCOR2 (if available)
TreeFam:
Gene Tree for NCOR2 (if available)

Paralogs for NCOR2 Gene

Paralogs for NCOR2 Gene

genes like me logo Genes that share paralogs with NCOR2: view

Variants for NCOR2 Gene

Sequence variations from dbSNP and Humsavar for NCOR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8546 -- 124,324,481(+) GCGCA(A/C/G)ATGGC utr-variant-3-prime
rs701021 -- 124,548,951(+) CTCTC(A/G)TTTCC intron-variant
rs701022 -- 124,550,867(-) GTGCC(C/T)GGGTG intron-variant
rs701023 -- 124,550,978(+) ACAAA(A/C)TACTA intron-variant
rs701024 -- 124,551,793(+) GGGCC(A/G)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOR2 Gene

Variant ID Type Subtype PubMed ID
nsv818930 CNV Gain 17921354
nsv899581 CNV Loss 21882294
dgv1499n71 CNV Loss 21882294
nsv470322 CNV Loss 18288195
nsv826536 CNV Gain 20364138
nsv832535 CNV Gain 17160897
dgv1500n71 CNV Loss 21882294
nsv826537 CNV Gain 20364138
nsv916 CNV Insertion 18451855
esv2662504 CNV Deletion 23128226
esv2746527 CNV Deletion 23290073
esv2746528 CNV Deletion 23290073
esv2666569 CNV Deletion 23128226
nsv455737 CNV Loss 19166990
nsv899587 CNV Loss 21882294
esv2428288 CNV Deletion 19546169
esv2746529 CNV Deletion 23290073
esv2746531 CNV Deletion 23290073
dgv1501n71 CNV Loss 21882294
esv2658789 CNV Deletion 23128226
esv2746532 CNV Deletion 23290073
dgv220e201 CNV Deletion 23290073
esv2746534 CNV Deletion 23290073
esv2746536 CNV Deletion 23290073
esv2746537 CNV Deletion 23290073
esv1526249 CNV Deletion 17803354
nsv455738 CNV Loss 19166990
esv1449756 CNV Insertion 17803354
nsv832538 CNV Loss 17160897
esv1465850 CNV Insertion 17803354
esv2130547 CNV Deletion 18987734
esv2746538 CNV Deletion 23290073
esv1008328 CNV Insertion 20482838
esv1669172 CNV Insertion 17803354
esv1118928 CNV Insertion 17803354
esv1772285 CNV Insertion 17803354
dgv1502n71 CNV Loss 21882294
nsv899591 CNV Loss 21882294
esv2746539 CNV Deletion 23290073
esv2746540 CNV Deletion 23290073
esv2746542 CNV Deletion 23290073
nsv899593 CNV Loss 21882294
nsv832539 CNV Loss 17160897
nsv455739 CNV Loss 19166990
nsv470323 CNV Loss 18288195
esv2664620 CNV Deletion 23128226
nsv821299 CNV Deletion 20802225
esv24001 CNV Gain 19812545
esv2670996 CNV Deletion 23128226

Relevant External Links for NCOR2 Gene

HapMap Linkage Disequilibrium report
NCOR2
Human Gene Mutation Database (HGMD)
NCOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR2 Gene

Disorders for NCOR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NCOR2 Gene including...

Search for NCOR2 Gene in MalaCards »

(13) Novoseek inferred disease relationships for NCOR2 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 60.4 3
promyelocytic leukemia 48.9 3
breast cancer 44.8 21
leukemogenesis 43.2 2
endometrial carcinoma 30.4 1

Relevant External Links for NCOR2

Genetic Association Database (GAD)
NCOR2
Human Genome Epidemiology (HuGE) Navigator
NCOR2
genes like me logo Genes that share disorders with NCOR2: view

No data available for UniProtKB/Swiss-Prot for NCOR2 Gene

Publications for NCOR2 Gene

  1. A transcriptional co-repressor that interacts with nuclear hormone receptors. (PMID: 7566127) Chen J.D. … Evans R.M. (Nature 1995) 2 3 4 23
  2. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. (PMID: 10097068) Park E.J. … Chen J.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PMID: 10944117) Li J. … Wong J. (EMBO J. 2000) 3 4 23
  4. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PMID: 12554770) Hauksdottir H. … Privalsky M.L. (Mol. Endocrinol. 2003) 3 4 23
  5. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PMID: 15632172) Goodson M.L. … Privalsky M.L. (J. Biol. Chem. 2005) 3 4 23

Products for NCOR2 Gene

Sources for NCOR2 Gene

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