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NCOR2 Gene

protein-coding GIFtS: 65

GC12M123333

nuclear receptor co-repressor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CTG26 ^¹, ², ³
N-CoR2 ^³
SMAP270 ^³
SMRT ^¹, ², ³, ⁵
SMRTE ^¹, ²
SMRTE-tau ^²
TNRC14 ^¹, ²
TRAC ^³
TRAC-1 ^¹, ²
TRAC1 ^²

Descriptions
CTG repeat protein 26 ^³
Silencing mediator of retinoic acid and thyroid hormone receptor ^³
T3 receptor-associating factor ^³
Thyroid-, retinoic-acid-receptor-associated corepressor ^³
nuclear receptor co-repressor 2 ^²
silencing mediator for retinoid and thyroid hormone receptors ^²

External Ids
HGNC: 7673¹
Entrez Gene: 9612²
UniProtKB: Q9Y618³
Ensembl: ENSG00000196498⁷

Search outside databases for aliases for NCOR2 gene

Previous GC identifers: GC12M123498 GC12M124551 GC12M123162

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618

Function: Mediates the transcriptional repression activity of some nuclear receptors by promoting

chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5

have different affinities for different nuclear receptors

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NCOR2 gene

Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24

NCOR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M123333: (about GC identifiers)

Start:	123,374,914 bp from pter
End:	123,586,102 bp from pter
Size:	211,189 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009755.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618 (See protein sequence)

Recommended Name: Nuclear receptor corepressor 2

Size: 2525 amino acids; 274804 Da

Subunit: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains

SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR)

and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their

interaction with TFIIB. Isoform SRMT interacts with HDAC10. Interacts with MINT. Component of the

N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

Interacts with CBFA2T3. Interacts with C1D (By similarity). Interacts with ATXN1L

Subcellular location: Nucleus

Sequence caution: Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of

unknown origin in the N-terminal part; Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794;

PDB structures from and Proteopedia :

1KKQ (3D)

1R2B (3D)

1XC5 (3D)

2ODD (3D)

Secondary accessions: O00613 O15416 O15421 Q13354 Q56D06 Q59GM0 Q9Y5U0

Alternative splicing: 5 isoforms: Q9Y618-1 Q9Y618-2 Q9Y618-3 Q9Y618-4 Q9Y618-5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001070729.1 NP_006303.3

ENSEMBL proteins:

ENSP00000380513 ENSP00000348551 ENSP00000385618 ENSP00000384202 ENSP00000384018

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HDAC3+NCOR2 complex, NCOR2)
	Human Recombinant Proteins from Abnova (NCOR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10097068
GO:0005730	NOT nucleolus	IDA	18029348

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Antibodies for NCOR2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NCOR2
	Sigma-Aldrich Antibodies for NCOR2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HDAC3+NCOR2 complex, NCOR2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NCOR2)
	Novus Biologicals Antibodies for NCOR2

Assays for NCOR2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y618

ProtoNet protein and cluster: Q9Y618

1 Blocks protein family: IPB001005 Myb DNA-binding domain

UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618

Domain: The N-terminal region contains repression functions that are divided into three independent

repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear

receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2)

Domain: The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box.

This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences

flanking the CORNR box determine nuclear hormone receptor specificity

Similarity: Belongs to the N-CoR nuclear receptor corepressors family

Similarity: Contains 2 SANT domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCOR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006312

Applied Biosystems Silencer® siRNAs for NCOR2

Sigma-Aldrich siRNA for NCOR2

Sigma-Aldrich shRNA Panels and shRNA for NCOR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001077261
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001077261
untagged cDNA clones in CMV expression vector (see all 2): NM_001077261

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006312

UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618

Function: Mediates the transcriptional repression activity of some nuclear receptors by promoting

chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5

have different affinities for different nuclear receptors

Induction: Regulated during cell cycle progression

Genatlas biochemistry entry for NCOR2:

nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone

receptors,ubiquitously expressed,recruiting the histone deacytylation complex

Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling and repression of transcription

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ncor2):

	adipose tissue	cellular	craniofacial	digestive/alimentary
growth/size	homeostasis/metabolism	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003714	transcription corepressor activity	TAS	7566127
GO:0005112	Notch binding	IPI	10713164
GO:0005515	protein binding	IPI	10713164 15016912

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for NCOR2 (Your Favorite Gene powered by Ingenuity) (see all 11 )

Aryl Hydrocarbon Receptor Signaling
PPAR&alpha
VDR/RXR Activation
Glucocorticoid Receptor Signaling
RAR Activation

GeneDecks NCOR2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NCOR2

5/130 Interacting proteins for NCOR2 (Q9Y618^{1, 2} ENSP00000348551³) via UniProtKB, MINT, and/or STRING (see all 130 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARA	Q07869², ENSP00000262735³	MINT-15842 MINT-15843 STRING (score=.968)
HDAC1	Q13547¹, ENSP00000362649³	EBI-80830, EBI-301834 STRING (score=.999)
HDAC10	Q969S8¹, ENSP00000216271³	EBI-80830, EBI-301762 STRING (score=.939)
AHR	P35869¹, ENSP00000242057³	EBI-80830, EBI-80780 STRING (score=.764)
PGR	P06401¹^,², ENSP00000325120³	EBI-80830, EBI-78539 MINT-4788120 EBI-80830, EBI-78539 MINT-4788120 STRING (score=.999)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NCOR2
10 Novoseek chemical compound relationships for NCOR2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	58.18	28	12554786 (2), 17671682 (1), 19183483 (1), 8798567 (1) (see all 22)
progesterone	36.78	6	9488452 (1), 11336882 (1), 16152593 (1), 17571860 (1) (see all 6)
estradiol	30.61	3	15802375 (1), 17047084 (1), 9171229 (1)
triiodothyronine	30.44	4	9169003 (1), 10598585 (1), 14601091 (1), 7566127 (1)
zinc	29.37	4	9819405 (1), 10938135 (1), 14982881 (1), 16042694 (1)
tcdd	22.35	2	12139968 (1)
lipid	0.00	1	8970730 (1)
tyrosine	0.00	3	9717842 (2), 10938135 (1)
cyclic amp	0.00	1	15525597 (1)
phosphatidylinositol	0.00	1	12907598 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCOR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006312

Sigma-Aldrich siRNA for NCOR2

Sigma-Aldrich shRNA Panels and shRNA for NCOR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001077261 NM_006312

REFSEQ mRNAs for NCOR2 gene (2 alternative transcripts):

NM_001077261.1 NM_006312.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001077261 NM_006312

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001077261
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001077261
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001077261

Additional cDNA sequence:

AB209089.1 AF113003.1 AF125672.1 AK127788.1 AY965853.1 BC004326.1 BC020427.1 S83390.1

U80750.1

24/30 DOTS entries (see all 30 ):

DT.75145963 DT.99938056 DT.91764966 DT.415951 DT.95275136 DT.95275164 DT.95275180 DT.100891061

DT.100891069 DT.99971084 DT.91721025 DT.100891065 DT.121148832 DT.427552 DT.102843151 DT.301927

DT.456041 DT.91764967 DT.91764976 DT.92061083 DT.95096710 DT.95190747 DT.95356935 DT.100686364

1 AceView cDNA sequence:

NM_006312

highest scoring ESTs for NCOR2:

BF743625 BF945940 AA160615 AA743831 AA748999 AA837468 AB209089 AF113003 AF125672 AI073795

Unigene Cluster for NCOR2:

Nuclear receptor co-repressor 2

Hs.137510 [show with all ESTs]

Unigene Representative Sequence: NM_006312

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for NCOR2 (see all 26 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	24c	^	25	^	26	^	27a	·	27b	·	27c	^	28a	·	28b	·	28c	^	29a	·	29b	^	30	^	31	^	32	^	33a	·	33b	·	33c	·	33d	^	34a	·	34b	·	34c	^	35	^	36a	·	36b	^	37	^	38a	·
SP1:																																			-		-
SP2:
SP3:
SP4:
SP5:

ExUns:	38b	^	39	^	40a	·	40b	·	40c	·	40d	^	41a	·	41b	·	41c	·	41d	^	42a	·	42b	·	42c	·	42d
SP1:	-																-		-
SP2:
SP3:	-				-		-		-		-						-		-
SP4:	-										-						-		-
SP5:	-

About this scheme

ECgene alternative splicing isoforms for NCOR2

5 Ensembl transcripts including schematic representations:

ENST00000397355 ENST00000356219 ENST00000404121 ENST00000404621 ENST00000405201

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NCOR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NCOR2

¹ / ² / ³

11 probe-sets matching NCOR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39359_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.32	0.24	S83390	0.60	1.00	0.82	1
39358_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.27	U37146	0.20	1.00	0.72	1
83991_at²^{, 3}	U95-D	1	1.00	1.00	0.87	0.73	AA764966	0.40	1.00	0.76	1
215205_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S83390	0.60	1.00	0.82	1
208889_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI373205	0.40	1.00	0.76	1
208888_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI499095	0.20	1.00	0.72	1
207760_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006312	0.60	1.00	0.82	1
215205_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208889_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208888_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207760_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTTCCCCAC

SOURCE GeneReport for Unigene cluster: Hs.137510
Expression variation in blood from EXPOLDB for NCOR2
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NCOR2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NCOR2¹	--	nuclear receptor co-repressor 2	85.62(n) 88.31(a)	486242 XM_847992.1 XP_853085.1
rat (Rattus norvegicus)	Ncor2¹	--	nuclear receptor co-repressor 2	84.51(n) 88.33(a)	360801 XM_341072.3 XP_341073.2
mouse (Mus musculus)	Ncor2^{1, 5}	5⁵	nuclear receptor co-repressor 2^{1, 5}	84.14(n)¹ 88.74(a)¹	20602¹ NM_011424.2¹ NP_035554.2¹ AF113001⁵ AF113002⁵ (see all 18)
chicken (Gallus gallus)	NCOR2¹	--	nuclear receptor co-repressor 2	75.17(n) 76.25(a)	416815 XM_415107.2 XP_415107.2
zebrafish (Danio rerio)	ncor2¹	--	nuclear receptor co-repressor 2	61.2(n) 59.19(a)	561503 XM_684906.3 XP_689998.3

About this table Species with no ortholog for NCOR2

ENSEMBL Gene Tree for NCOR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NCOR2 gene

C20orf191² NCOR1² ENSG00000205203²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1479 NCBI SNPs in NCOR2 are shown (see all 1479 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 467)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8546^1,2	A,C,F,H	123374980(+)	`GCGCAG/AATGGC`	2	--	ut3¹		7		MN EU EA WA	1716
	rs872224^1,2	A,C,F,H	123545786(-)	`TATTGG/CGGCCT`	2	--	ut5¹		6		MN EU EA WA	1706
--	rs837462^1,2	A,C,F,H	123587668(+)	`CGCCAA/GTCACC`	2	--	ng3¹		4		EU EA WA	418
	rs2229840^1,2	C,F,H	123392415(-)	`ACAACG/ACGGCC`	2	T/A	mis¹ ese³		6		MN EU EA WA NA	476
	rs1472840^1,2	C,F,H	123383759(-)	`ACAAGA/CCGTCG`	2	T/P	mis¹ ese³		6		MN EU EA WA NA	658
--	rs837461^1,2	A,C,F	123587760(+)	`TTTATC/TGTGTT`	2	--	ng3¹		2		NA	182
	rs2230944^1,2	C,F,H	123387366(-)	`TCGCAC/TCTCAC`	2	P/S	mis¹ ese³		9		MN NA EU EA WA	642
--	rs7294442^1,2	A,C	123374793(+)	`AAAGGA/CTCCAC`	2	--	ng5¹		0	--	--	--	--
	rs2227277^1,2	C,F	123387369(-)	`ACCTCG/ACACCT`	2	T/A	mis¹ ese³		3		MN NA	150
	rs12422607^1,2	H	123391128(+)	`GTGGCG/AGCTGC`	2	C/R	mis¹ ese³		4		EU EA WA	396

About this table

HapMap Linkage Disequilibrium images for NCOR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600848

10/13 Novoseek disease relationships for NCOR2 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	61.93	3	11585900 (2), 9256429 (1)
promyelocytic leukemia	50.52	3	10938135 (1), 14982881 (1), 9765306 (1)
leukemogenesis	45.02	2	11929748 (1), 11585900 (1)
breast cancer	40.01	18	15802375 (3), 18546531 (2), 10690532 (1), 10828836 (1) (see all 11)
prostate cancer	27.58	10	15300237 (3), 15948728 (2), 17804755 (2), 16373395 (1) (see all 5)
leukemia	17.75	2	10611298 (1), 16042694 (1)
endometrial carcinoma	16.61	1	14751175 (1)
cancer	11.37	1	11336882 (1)
lymphoma non-hodgkins	11.35	5	15930272 (3), 9753732 (1)
necrosis	0.00	1	15811852 (1)

About this table

Genetic Association Database: NCOR2
Human Genome Epidemiology Navigator: NCOR2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/268 PubMed articles for NCOR2 gene (see all 268 ):

A transcriptional co-repressor that interacts with nuclear hormone receptors. (PubMed id 7566127)^{1, 2, 3, 4} Chen J.D. and Evans R.M. (1995)
Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. (PubMed id 8813722)^{2, 3, 4} Sande S. and Privalsky M.L. (1996)
Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PubMed id 15632172)^{1, 3, 4} Goodson M.L....Privalsky M.L. (2005)
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PubMed id 10944117)^{1, 3, 4} Li J.... Wong J. (2000)
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40- repeat protein linked to deafness. (PubMed id 10809664)^{1, 3, 4} Guenther M.G....Shiekhattar R. (2000)
SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. (PubMed id 10097068)^{1, 3, 4} Park E.J.... Chen J.D. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Exclusion of non-synonymous SNPs and a polyglutamine tract in SMRT/N-CoR2 as common deleterious mutation for bipolar disorder in the Sagnenay-Lac-St-Jean population. (PubMed id 15635693)^{3, 6} Shink E....Barden N. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)^{3, 4} Zhang J....Roeder R.G. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9612	HGNC: 7673	AceView: NCOR2	Ensembl:ENSG00000196498	euGenes: HUgn9612
ECgene: NCOR2	H-InvDB: NCOR2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NCOR2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NCOR2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NCOR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NCOR2-related products

	Millipore Custom Antibody & Bulk Services
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NCOR2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for NCOR2

Summaries
for NCOR2

Genomic Location
for NCOR2

Proteins
for NCOR2

Protein Domains/
Families
for NCOR2

Gene Function
for NCOR2

Pathways & Interactions
for NCOR2

Drugs & Compounds
for NCOR2

Transcripts
for NCOR2

Expression
for NCOR2

Orthologs
for NCOR2

Paralogs
for NCOR2

SNPs/Variants
for NCOR2

Disorders & Mutations
for NCOR2

Medical News
for NCOR2

Publications
for NCOR2

Search for NCOR2

Genome Databases showing NCOR2

Other Databases showing NCOR2

Specialized Databases showing NCOR2

Licensable Technologies
for NCOR2

Services
for NCOR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NCOR2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor NCOR2

Summariesfor NCOR2

Genomic Locationfor NCOR2

Proteinsfor NCOR2

Protein Domains/Familiesfor NCOR2

Gene Functionfor NCOR2

Pathways & Interactionsfor NCOR2

Drugs & Compoundsfor NCOR2

Transcriptsfor NCOR2

Expression for NCOR2

Orthologsfor NCOR2

Paralogsfor NCOR2

SNPs/Variantsfor NCOR2

Disorders & Mutationsfor NCOR2

Medical Newsfor NCOR2

Publicationsfor NCOR2

Search for NCOR2

Genome Databases showing NCOR2

Other Databases showing NCOR2

Specialized Databases showing NCOR2

Licensable Technologiesfor NCOR2

Servicesfor NCOR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NCOR2

Summaries
for NCOR2

Genomic Location
for NCOR2

Proteins
for NCOR2

Protein Domains/
Families
for NCOR2

Gene Function
for NCOR2

Pathways & Interactions
for NCOR2

Drugs & Compounds
for NCOR2

Transcripts
for NCOR2

Expression
for NCOR2

Orthologs
for NCOR2

Paralogs
for NCOR2

SNPs/Variants
for NCOR2

Disorders & Mutations
for NCOR2

Medical News
for NCOR2

Publications
for NCOR2

Licensable Technologies
for NCOR2

Services
for NCOR2