NCOR2 Gene
protein-coding GIFtS: 66
GCID: GC12M124808
|
|
nuclear receptor corepressor 2(Previous name: nuclear receptor co-repressor 2 )
| |
Aliases
for NCOR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Corepressor 21 2 | | TRAC2 3 | | SMRT1 2 3 5 | | CTG Repeat Protein 262 3 | | CTG261 2 3 | | T3 Receptor-Associating Factor2 3 | | SMRTE1 2 | | Nuclear Receptor Co-Repressor 21 | | TNRC141 2 | | SMRTE-Tau1 | | TRAC-11 2 | | TRAC12 | | Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor2 3 | | Silencing Mediator For Retinoid And Thyroid Hormone Receptors2 | | N-CoR22 3 | | Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor3 | | SMAP2702 3 | | |
Export aliases for NCOR2 gene to outside databasesPrevious GC identifers: GC12M123498 GC12M124551 GC12M123162 GC12M123333 GC12M121771 |
Summaries
for NCOR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCOR2:
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. Theencoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. Thisprotein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure thatprevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certaincancers. Alternate splicing results in multiple transcript variants encoding different isoforms.(provided by RefSeq,Apr 2011)
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618Function: Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters ofNR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repressionactivity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basaltranscription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors
Gene Wiki entry for NCOR2 (Nuclear receptor co-repressor 2)
|
Genomic Views
for NCOR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCOR2 gene promoter:
ATF-2 AP-2gamma HEN1 RORalpha1 GATA-6 POU2F1a AP-2beta c-Jun AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCOR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24NCOR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M124808: view genomic region
(about GC identifiers)
Start:
|
124,808,961 bp from pter |
End:
|
125,052,135 bp from pter |
Size:
|
243,175 bases |
Orientation:
|
minus strand |
|
Proteins
for NCOR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618 (See
protein sequence)Recommended Name: Nuclear receptor corepressor 2 Size: 2525 amino acids; 274804 Da
Subunit: Interacts with BCL6, HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3(By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2.This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and maystabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interactionrepresses RARA activity. Interacts (isoform SRMT) with HDAC10. Interacts with MINT. Component of the N-Cor repressorcomplex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L.Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity
Subcellular location: Nucleus
Sequence caution: Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAC50236.1;Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794; Sequence=BAD92326.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
6/10 PDB 3D structures from  and Proteopedia  for NCOR2 (see all 10):1KKQ (3D)
1R2B (3D)
1XC5 (3D)
2GPV (3D)
2L5G (3D)
2LTP (3D)
Secondary accessions: O00613 O15416 O15421 Q13354 Q56D06 Q59GM0 Q9Y5U0Alternative splicing: 5 isoforms: Q9Y618-1 Q9Y618-2 Q9Y618-3 Q9Y618-4 Q9Y618-5 (Contains only the C-terminal receptor-interacting domain and acts as an antirepressor)Explore the universe of human proteins at neXtProt for NCOR2: NX_Q9Y618
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y618
NCOR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001070729.2 NP_001193583.1 NP_006303.4
ENSEMBL proteins: ENSP00000384018 ENSP00000384202 ENSP00000400281 ENSP00000391389 ENSP00000405246 ENSP00000407357 ENSP00000398963 ENSP00000396044 ENSP00000400687 ENSP00000402808 ENSP00000408247 ENSP00000405367 ENSP00000443689 ENSP00000403034 ENSP00000348551 ENSP00000380513 ENSP00000385618 Reactome Protein details: Q9Y618
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
NCOR2 for ontologies About GeneDecksing
NCOR2 Antibody Products:
Assay Products for NCOR2: |
Protein
Domains /
Families
for NCOR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCOR2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y618ProtoNet protein and cluster: Q9Y618 1 Blocks protein family: IPB001005 Myb DNA-binding domain
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618Domain: The N-terminal region contains repression functions that are divided into three independent repression domains(RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in twoseparate interaction domains (ID1 and ID2)Domain: The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif isrequired and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclearhormone receptor specificitySimilarity: Belongs to the N-CoR nuclear receptor corepressors familySimilarity: Contains 2 SANT domains |
Function
for NCOR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618Function: Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters ofNR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repressionactivity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basaltranscription. Isoform 1 and isoform 5 have different affinities for different nuclear receptorsInduction: Regulated during cell cycle progression Genatlas biochemistry entry for NCOR2:nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone receptors,ubiquitouslyexpressed,recruiting the histone deacytylation complex Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling andrepression of transcription
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NCOR2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NCOR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR2 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
NCOR2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for NCOR2:
Animal Models:
Mouse knock-out Ncor2tm1Kjep for NCOR2
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ncor2):
NCOR2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NCOR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 3 | Notch Signaling Pathway | | | 4 | Transcription_Sin3 and NuRD in transcription regulation | | | 5 | Development_Notch Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for NCOR2
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOR2 (see all 7)
5  GeneGo (Thomson Reuters) Pathways for NCOR2
5/10  BioSystems Pathways for NCOR2 (see all 10)
5/24 
Reactome Pathways for NCOR2 (see all 24)
1 
Kegg Pathway (Kegg details for NCOR2):
NCOR2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOR2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/758 Interacting proteins for NCOR2 (Q9Y6181, 2, 3 ENSP000003485514) via UniProtKB, MINT, STRING, and/or I2D (see all 758)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | -- | | GO:0001701 | in utero embryonic development |
-- | -- | | GO:0003007 | heart morphogenesis |
-- | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- |
NCOR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCOR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCOR2 for compounds About GeneDecksing
 Browse Tocris compounds for NCOR2
1 HMDB Compound for NCOR2 About this table
10/21 Novoseek chemical compound relationships for NCOR2 gene (see all 21) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoid |
90.3 |
99 |
11435691 (2), 18981260 (2), 11855864 (2), 9092799 (1) (see all 85) |
| retinoic acid |
77.1 |
59 |
9169003 (3), 9717842 (3), 17519355 (2), 17591692 (2) (see all 45) |
| steroid |
59.5 |
32 |
12554786 (2), 17671682 (1), 19183483 (1), 19432593 (1) (see all 26) |
| estrogen |
59.2 |
20 |
17591692 (3), 15802375 (2), 16152593 (2), 20406620 (2) (see all 12) |
| 4-hydroxytamoxifen |
58.8 |
10 |
9171229 (4), 14715875 (1), 16990259 (1), 17047084 (1) |
| tamoxifen |
56.3 |
41 |
15802375 (5), 18546531 (5), 20406620 (3), 19904269 (2) (see all 13) |
| cyproteroneacetate |
52.7 |
10 |
11923464 (3), 19223455 (3), 15617028 (1) |
| vitamin d |
43.4 |
17 |
19098224 (3), 17855664 (1), 18981260 (1), 14985122 (1) (see all 9) |
| progesterone |
41.8 |
10 |
20392877 (2), 9488452 (1), 11336882 (1), 16152593 (1) (see all 8) |
| zinc |
32 |
4 |
9819405 (1), 10938135 (1), 14982881 (1), 16042694 (1) |
Search CenterWatch for drugs/clinical trials and news about NCOR2
|
Transcripts
for NCOR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCOR2 gene (3 alternative transcripts): NM_001077261.3 NM_001206654.1 NM_006312.5 Unigene Cluster for NCOR2: Nuclear receptor corepressor 2 Hs.137510 [show with all ESTs]Unigene Representative Sequence: NM_00631218/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000405201 ENST00000404621(uc010tax.2 uc010tbc.2) ENST00000429285
ENST00000418829 ENST00000443451 ENST00000413172 ENST00000464377 ENST00000440337
ENST00000461081 ENST00000474079 ENST00000440187 ENST00000453428 ENST00000458234(uc001ugj.1)
ENST00000473999 ENST00000536195 ENST00000493859 ENST00000448614 ENST00000420698(uc001ugk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NCOR2 (NM_001077261) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOR2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NCOR2 |
Additional cDNA sequence: AB209089.1 AF113003.1 AF125672.1 AK127788.1 AY965853.1 BC004326.1 BC020427.1 S83390.1 U80750.1 24/26 DOTS entries (see all 26): DT.75145963 DT.99938056 DT.91764966 DT.415951 DT.95275136 DT.95275164 DT.95275180 DT.100891061 DT.100891069 DT.99971084 DT.91721025 DT.100891065 DT.220293 DT.427552 DT.121148832 DT.95096710 DT.102843151 DT.301927 DT.91764967 DT.91764976 DT.92061083 DT.95275176 DT.95356935 DT.91928104 1 AceView cDNA sequence: NM_006312
GeneLoc Exon Structure
5/26 Alternative Splicing Database (ASD) splice patterns (SP) for NCOR2 (see all 26) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24c | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | · | 28c | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | · | 33c | · | 33d | ^ | 34a | · | 34b | · | 34c | ^ | 35 | ^ | 36a | · | 36b | ^ | 37 | ^ | 38a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 38b | ^ | 39 | ^ | 40a | · | 40b | · | 40c | · | 40d | ^ | 41a | · | 41b | · | 41c | · | 41d | ^ | 42a | · | 42b | · | 42c | · | 42d |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | - | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP5: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCOR2
|
Expression
for NCOR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCOR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTCCCCAC
About this image
See NCOR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCOR2
SOURCE GeneReport for Unigene cluster: Hs.137510
UniProtKB/Swiss-Prot: NCOR2_HUMAN, Q9Y618Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain
SABiosciences Expression via Pathway-Focused PCR Arrays including NCOR2:
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR2 |
Orthologs
for NCOR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NCOR2 gene from 8/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ncor21 , 5 |
nuclear receptor co-repressor 21, 5 |
84.15(n)1
88.62(a)1 |
|
5 (63.96 cM)5
206021 NM_011424.31 NP_035554.31
1250171535 |
chicken
(Gallus gallus) |
Aves |
NCOR21 |
nuclear receptor corepressor 2 |
75.31(n)
76.58(a) |
|
416815 XM_415107.3 XP_415107.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NCOR26 |
-- |
67(a) |
1 ↔ 1 |
LGb(1459361-1575711) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL858988.22 |
-- |
78.47(n) |
|
AL858988.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
ncor21 |
nuclear receptor co-repressor 2 |
61.25(n)
59.32(a) |
|
561503 XM_684906.5 XP_689998.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Smr6 |
Smrter |
10(a) |
1 → many |
X(12578236-12636477) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G522506 |
duplicated SANT DNA-binding domain-containing prot... |
8(a) |
1 → many |
3(19376138-19383100) |
rice
(Oryza sativa) |
Liliopsida |
AB071804.12 |
-- |
70.81(n) |
|
AB071804.1 |
ENSEMBL Gene Tree for NCOR2 (if available)
TreeFam Gene Tree for NCOR2 (if available) |
Paralogs
for NCOR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCOR2 gene
- NCOR12 RCOR22 RCOR12 RCOR32
2 SIMAP similar genes for NCOR2 using alignment to 17 protein entries: NCOR2_HUMAN (see all proteins):NCOR1 NCOR1P1
NCOR2 for paralogs About GeneDecksing
|
Genomic Variants
for NCOR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCOR2 (124808961 - 125052135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NCOR2
6 CNVs: 29929 29927 29926 4792 29928 9699 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOR2 |
|
Disorders
/ Diseases
for NCOR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCOR2 for disorders About GeneDecksing
OMIM gene information: 600848
OMIM disorders: --
20/39  diseases for NCOR2 (see all 39): About MalaCardsthyroiditis thyroid hormone resistance syndrome non-hodgkin lymphoma cortisol resistance
b-cell lymphomas acute promyelocytic leukemia hodgkin's lymphoma sporadic breast cancer
acute myeloid leukemia myeloid leukemia endometrial carcinoma ovarian endometriosis
myeloid malignancy bipolar disorder pituitary tumor multiple myeloma
leukemia breast cancer endometriosis ovarian cancer
10/13 Novoseek disease relationships for NCOR2 gene (see all 13) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia promyelocytic acute |
60.4 |
3 |
11585900 (2), 9256429 (1) |
| promyelocytic leukemia |
48.9 |
3 |
10938135 (1), 14982881 (1), 9765306 (1) |
| breast cancer |
44.8 |
32 |
19904269 (3), 15802375 (3), 20392877 (2), 18546531 (2) (see all 15) |
| leukemogenesis |
43.2 |
2 |
11929748 (1), 11585900 (1) |
| endometrial carcinoma |
30.4 |
1 |
14751175 (1) |
| prostate cancer |
24.9 |
10 |
15300237 (3), 15948728 (2), 17804755 (2), 16373395 (1) (see all 5) |
| leukemia |
15.6 |
2 |
10611298 (1), 16042694 (1) |
| lymphoma non-hodgkins |
9.26 |
5 |
15930272 (3), 9753732 (1) |
| cancer |
7.71 |
1 |
11336882 (1) |
| necrosis |
0 |
1 |
15811852 (1) |
Genetic Association Database (GAD): NCOR2
Human Genome Epidemiology (HuGE) Navigator: NCOR2 (13 documents)
Export disorders for NCOR2 gene to outside databases
|
Publications
for NCOR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCOR2 gene, integrated from 9 sources (see all 365):
(articles sorted by number of sources associating them with NCOR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A transcriptional co-repressor that interacts with nuclear hormone receptors. (PubMed id 7566127)1, 2, 3, 9 Chen J.D. and Evans R.M. (1995)
- Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. (PubMed id 8813722)1, 2, 3 Sande S. and Privalsky M.L. (1996)
- Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PubMed id 15632172)1, 2, 9 Goodson M.L.... Privalsky M.L. (2005)
- Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PubMed id 10944117)1, 2, 9 Li J.... Wong J. (2000)
- Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PubMed id 12554770)1, 2, 9 Hauksdottir H....Privalsky M.L. (2003)
- A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40- repeat protein linked to deafness. (PubMed id 10809664)1, 2, 9 Guenther M.G....Shiekhattar R. (2000)
- SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. (PubMed id 10097068)1, 2, 9 Park E.J.... Chen J.D. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Exclusion of non-synonymous SNPs and a polyglutamine tract in SMRT/N-CoR2 as common deleterious mutation for bipolar disorder in the Sagnenay-Lac-St-Jean population. (PubMed id 15635693)1, 4 Shink E....Barden N. (2005)
- Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. (PubMed id 16121196)1, 2 Mizutani A....Tsai C.C. (2005)
|
External Searches for NCOR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCOR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCOR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCOR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NCOR2 gene:
Search GeneIP for patents involving NCOR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCOR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NCOR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOR2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCOR2 | | OriGene 3'-UTR Clone for NCOR2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NCOR2 | | OriGene Custom Protein Services for NCOR2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCOR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOR2 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR2 |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NCOR2 |
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