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Aliases for NCOR1 Gene

Aliases for NCOR1 Gene

  • Nuclear Receptor Corepressor 1 2 3 5
  • Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 1 2 3
  • Protein Phosphatase 1, Regulatory Subunit 109 2 3
  • N-CoR1 3 4
  • N-CoR 3 4
  • Nuclear Receptor Co-Repressor 1 2
  • PPP1R109 3
  • KIAA1047 4
  • HN-CoR 3
  • TRAC1 3

External Ids for NCOR1 Gene

Previous GeneCards Identifiers for NCOR1 Gene

  • GC17M016297
  • GC17M017045
  • GC17M015877
  • GC17M016135
  • GC17M015875
  • GC17M015933

Summaries for NCOR1 Gene

Entrez Gene Summary for NCOR1 Gene

  • This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

GeneCards Summary for NCOR1 Gene

NCOR1 (Nuclear Receptor Corepressor 1) is a Protein Coding gene. Diseases associated with NCOR1 include Leukemia, Acute Promyelocytic, Somatic and Rett Syndrome. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NCOR2.

UniProtKB/Swiss-Prot for NCOR1 Gene

  • Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Gene Wiki entry for NCOR1 Gene

Additional gene information for NCOR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOR1 Gene

Genomics for NCOR1 Gene

Regulatory Elements for NCOR1 Gene

Enhancers for NCOR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H016406 1.9 FANTOM5 Ensembl ENCODE dbSUPER 106.6 -189.5 -189526 2 HDGF ZNF493 ZFP64 SIN3A FEZF1 YBX1 ZNF121 GLIS2 ZNF207 KLF7 PIGL PPIAP53 NCOR1 ENSG00000266538 TVP23C MPRIP-AS1 LOC644422 ZNF286A ENSG00000264729 MEIS3P1
GH17H016377 1.7 Ensembl ENCODE dbSUPER 44.9 -161.9 -161916 4 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A ZNF610 GLIS1 NBN ENSG00000266538 NCOR1 PPIAP53 PIGL TVP23C LOC644422 LRRC75A-AS1 FLCN ACTG1P24 ZNF286A
GH17H016438 1.4 ENCODE dbSUPER 43 -223.2 -223234 6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NCOR1 PIGL PPIAP53 ENSG00000266538 LRRC75A-AS1 TVP23C LOC644422 FLCN RPL13P12 ZNF286A
GH17H017040 1.6 FANTOM5 ENCODE dbSUPER 31.9 -825.7 -825679 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MPRIP-AS1 FLCN PIGL PLD6 NCOR1 MPRIP SMCR5 LOC100419436 ZNF624 ZNF287
GH17H015464 1.1 FANTOM5 dbSUPER 31.9 +753.2 753184 0 ZSCAN5A ZNF146 SUZ12 ZSCAN4 ZNF133 ZNF175 ZNF266 CDC5L ZKSCAN1 ZNF791 NCOR1 ENSG00000266538 PIGL MEIS3P1 ENSG00000265519 TVP23C PPIAP53 LRRC75A-AS1 ZNF286A RPS18P12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCOR1 on UCSC Golden Path with GeneCards custom track

Promoters for NCOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091730 685 1801 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for NCOR1 Gene

Chromosome:
17
Start:
16,029,157 bp from pter
End:
16,218,185 bp from pter
Size:
189,029 bases
Orientation:
Minus strand

Genomic View for NCOR1 Gene

Genes around NCOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOR1 Gene

Proteins for NCOR1 Gene

  • Protein details for NCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75376-NCOR1_HUMAN
    Recommended name:
    Nuclear receptor corepressor 1
    Protein Accession:
    O75376
    Secondary Accessions:
    • B3DLF8
    • E9PGV6
    • Q86YY0
    • Q9UPV5
    • Q9UQ18

    Protein attributes for NCOR1 Gene

    Size:
    2440 amino acids
    Molecular mass:
    270210 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA. Interacts with RXRA. Interacts with SETD5 (By similarity).
    SequenceCaution:
    • Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR1 Gene

    Alternative splice isoforms for NCOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR1 Gene

Post-translational modifications for NCOR1 Gene

  • Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NCOR1 Gene

Domains & Families for NCOR1 Gene

Gene Families for NCOR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NCOR1 Gene

Graphical View of Domain Structure for InterPro Entry

O75376

UniProtKB/Swiss-Prot:

NCOR1_HUMAN :
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • Belongs to the N-CoR nuclear receptor corepressors family.
Domain:
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR1: view

Function for NCOR1 Gene

Molecular function for NCOR1 Gene

GENATLAS Biochemistry:
nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS
UniProtKB/Swiss-Prot Function:
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Phenotypes From GWAS Catalog for NCOR1 Gene

Gene Ontology (GO) - Molecular Function for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19955185
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA,IMP 12628926
GO:0005515 protein binding IPI 10049357
GO:0016922 ligand-dependent nuclear receptor binding IBA --
genes like me logo Genes that share ontologies with NCOR1: view
genes like me logo Genes that share phenotypes with NCOR1: view

Animal Models for NCOR1 Gene

MGI Knock Outs for NCOR1:

Animal Model Products

CRISPR Products

miRNA for NCOR1 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR1 Gene

Localization for NCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 18326024
GO:0000790 nuclear chromatin IDA 17505061
GO:0005634 nucleus IDA,IEA 10049357
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NCOR1: view

Pathways & Interactions for NCOR1 Gene

genes like me logo Genes that share pathways with NCOR1: view

SIGNOR curated interactions for NCOR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7566114
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with NCOR1: view

Drugs & Compounds for NCOR1 Gene

(11) Drugs for NCOR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for NCOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOR1: view

Transcripts for NCOR1 Gene

Unigene Clusters for NCOR1 Gene

Nuclear receptor corepressor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:

Relevant External Links for NCOR1 Gene

GeneLoc Exon Structure for
NCOR1
ECgene alternative splicing isoforms for
NCOR1

Expression for NCOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOR1 Gene

Protein differential expression in normal tissues from HIPED for NCOR1 Gene

This gene is overexpressed in Urine (23.5), Spinal cord (18.4), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOR1 Gene



Protein tissue co-expression partners for NCOR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCOR1 Gene:

NCOR1

SOURCE GeneReport for Unigene cluster for NCOR1 Gene:

Hs.462323

Evidence on tissue expression from TISSUES for NCOR1 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Thyroid gland(3.2)
  • Intestine(3.1)
  • Kidney(2.4)
  • Lung(2.3)
  • Muscle(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with NCOR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR1 Gene

Orthologs for NCOR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOR1 34 33
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCOR1 33 34
  • 91.7 (n)
mouse
(Mus musculus)
Mammalia Ncor1 16 34 33
  • 89.11 (n)
rat
(Rattus norvegicus)
Mammalia Ncor1 33
  • 89.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NCOR1 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCOR1 34 33
  • 85.6 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOR1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOR1 33 34
  • 79.18 (n)
lizard
(Anolis carolinensis)
Reptilia NCOR1 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncor1 33
  • 70.6 (n)
Str.16187 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398304 33
zebrafish
(Danio rerio)
Actinopterygii ncor1 33 34
  • 62.06 (n)
zgc56355 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNT1 34 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for NCOR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOR1 Gene

ENSEMBL:
Gene Tree for NCOR1 (if available)
TreeFam:
Gene Tree for NCOR1 (if available)

Paralogs for NCOR1 Gene

Variants for NCOR1 Gene

Sequence variations from dbSNP and Humsavar for NCOR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs886039691 Pathogenic 16,217,286(+) CTCTG(A/G)GTTTG upstream-variant-2KB, reference, stop-gained
rs1057518948 Uncertain significance 16,217,402(+) TGCTC(A/C)CACAG upstream-variant-2KB, reference, missense
rs147669920 Uncertain significance 16,217,256(+) GTGGC(G/T)TTGGC upstream-variant-2KB, reference, synonymous-codon
rs150000731 Uncertain significance 16,217,230(+) TCATG(A/G)AAGCA upstream-variant-2KB, reference, missense
rs587784324 Uncertain significance 16,217,395(+) TGTTT(C/T)TTGCT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NCOR1 Gene

Variant ID Type Subtype PubMed ID
dgv1426n106 CNV duplication 24896259
dgv3107n100 CNV gain 25217958
dgv3108n100 CNV gain 25217958
esv2661970 CNV deletion 23128226
esv2715702 CNV deletion 23290073
esv3335248 CNV insertion 20981092
esv3416216 CNV insertion 20981092
esv3554199 CNV deletion 23714750
esv3554201 CNV deletion 23714750
esv3554202 CNV deletion 23714750
esv3572431 CNV gain 25503493
esv3640096 CNV loss 21293372
esv3640097 CNV loss 21293372
esv3640098 CNV loss 21293372
esv3892973 CNV gain 25118596
nsv1070814 CNV deletion 25765185
nsv112235 CNV deletion 16902084
nsv1134603 CNV deletion 24896259
nsv1138502 CNV deletion 24896259
nsv1150926 CNV duplication 26484159
nsv522169 CNV gain 19592680
nsv528263 CNV loss 19592680
nsv833377 CNV loss 17160897
nsv960422 CNV duplication 23825009
nsv960423 CNV duplication 23825009
nsv962265 CNV duplication 23825009

Variation tolerance for NCOR1 Gene

Residual Variation Intolerance Score: 0.651% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOR1 Gene

Human Gene Mutation Database (HGMD)
NCOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR1 Gene

Disorders for NCOR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NCOR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
rett syndrome
  • rett syndrome, preserved speech variant
huntington disease
  • huntington's disease
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search NCOR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOR1

Genetic Association Database (GAD)
NCOR1
Human Genome Epidemiology (HuGE) Navigator
NCOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOR1
genes like me logo Genes that share disorders with NCOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR1 Gene

Publications for NCOR1 Gene

  1. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 45 60
  2. Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PMID: 17519354) Ewing AK … Chakravarti D (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 22 60
  3. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PMID: 16024779) Zhang D … Wong J (Molecular and cellular biology 2005) 3 4 22 60
  4. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PMID: 14525983) Wu K … Pestell RG (The Journal of biological chemistry 2003) 3 4 22 60
  5. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PMID: 9724795) Wang J … Liu JM (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60

Products for NCOR1 Gene

Sources for NCOR1 Gene

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