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Aliases for NCOR1 Gene

Aliases for NCOR1 Gene

  • Nuclear Receptor Corepressor 1 2 3 5
  • Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 1 2 3
  • Nuclear Receptor Co-Repressor 1 2 3
  • N-CoR1 3 4
  • N-CoR 3 4
  • Protein Phosphatase 1, Regulatory Subunit 109 3
  • Regulatory Subunit 109 2
  • Protein Phosphatase 1 2
  • PPP1R109 3
  • KIAA1047 4
  • HN-CoR 3
  • TRAC1 3

External Ids for NCOR1 Gene

Previous GeneCards Identifiers for NCOR1 Gene

  • GC17M016297
  • GC17M017045
  • GC17M015877
  • GC17M016135
  • GC17M015875
  • GC17M015933

Summaries for NCOR1 Gene

Entrez Gene Summary for NCOR1 Gene

  • This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

GeneCards Summary for NCOR1 Gene

NCOR1 (Nuclear Receptor Corepressor 1) is a Protein Coding gene. Diseases associated with NCOR1 include leukemia, acute promyelocytic, somatic and leukemia, acute myeloid. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is RCOR2.

UniProtKB/Swiss-Prot for NCOR1 Gene

  • Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Gene Wiki entry for NCOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOR1 Gene

Genomics for NCOR1 Gene

Regulatory Elements for NCOR1 Gene

Genomic Location for NCOR1 Gene

Chromosome:
17
Start:
16,029,157 bp from pter
End:
16,218,185 bp from pter
Size:
189,029 bases
Orientation:
Minus strand

Genomic View for NCOR1 Gene

Genes around NCOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOR1 Gene

Proteins for NCOR1 Gene

  • Protein details for NCOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75376-NCOR1_HUMAN
    Recommended name:
    Nuclear receptor corepressor 1
    Protein Accession:
    O75376
    Secondary Accessions:
    • B3DLF8
    • E9PGV6
    • Q86YY0
    • Q9UPV5
    • Q9UQ18

    Protein attributes for NCOR1 Gene

    Size:
    2440 amino acids
    Molecular mass:
    270210 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA.
    SequenceCaution:
    • Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR1 Gene

    Alternative splice isoforms for NCOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR1 Gene

Proteomics data for NCOR1 Gene at MOPED

Post-translational modifications for NCOR1 Gene

  • Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCOR1 (N-CoR1)

No data available for DME Specific Peptides for NCOR1 Gene

Domains & Families for NCOR1 Gene

Protein Domains for NCOR1 Gene

Graphical View of Domain Structure for InterPro Entry

O75376

UniProtKB/Swiss-Prot:

NCOR1_HUMAN :
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • Belongs to the N-CoR nuclear receptor corepressors family.
Domain:
  • The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
  • The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).
  • Contains 2 SANT domains.
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR1: view

Function for NCOR1 Gene

Molecular function for NCOR1 Gene

GENATLAS Biochemistry:
nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS
UniProtKB/Swiss-Prot Function:
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Gene Ontology (GO) - Molecular Function for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0035257 nuclear hormone receptor binding IPI 9328355
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with NCOR1: view
genes like me logo Genes that share phenotypes with NCOR1: view

Animal Models for NCOR1 Gene

MGI Knock Outs for NCOR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCOR1

miRNA for NCOR1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR1 Gene

Localization for NCOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOR1 Gene COMPARTMENTS Subcellular localization image for NCOR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005876 spindle microtubule IDA 18326024
GO:0016580 colocalizes_with Sin3 complex IDA 11486045
genes like me logo Genes that share ontologies with NCOR1: view

Pathways & Interactions for NCOR1 Gene

SuperPathways for NCOR1 Gene

genes like me logo Genes that share pathways with NCOR1: view

SIGNOR curated interactions for NCOR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007595 lactation IEA --
genes like me logo Genes that share ontologies with NCOR1: view

Drugs & Compounds for NCOR1 Gene

(12) Drugs for NCOR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for NCOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOR1: view

Transcripts for NCOR1 Gene

Unigene Clusters for NCOR1 Gene

Nuclear receptor corepressor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:

Relevant External Links for NCOR1 Gene

GeneLoc Exon Structure for
NCOR1
ECgene alternative splicing isoforms for
NCOR1

Expression for NCOR1 Gene

mRNA expression in normal human tissues for NCOR1 Gene

Protein differential expression in normal tissues from HIPED for NCOR1 Gene

This gene is overexpressed in Urine (23.5), Spinal cord (18.4), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOR1 Gene



SOURCE GeneReport for Unigene cluster for NCOR1 Gene Hs.462323

genes like me logo Genes that share expression patterns with NCOR1: view

Protein tissue co-expression partners for NCOR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCOR1 Gene

Orthologs for NCOR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCOR1 35
  • 85.6 (n)
  • 91.08 (a)
NCOR1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOR1 35
  • 91.7 (n)
  • 95.03 (a)
NCOR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncor1 35
  • 89.11 (n)
  • 92.78 (a)
Ncor1 16
Ncor1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCOR1 35
  • 99.28 (n)
  • 99.37 (a)
NCOR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncor1 35
  • 89.02 (n)
  • 92.46 (a)
oppossum
(Monodelphis domestica)
Mammalia NCOR1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOR1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOR1 35
  • 79.18 (n)
  • 85.53 (a)
NCOR1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOR1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncor1 35
  • 70.6 (n)
  • 73.79 (a)
Str.16187 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398304 35
zebrafish
(Danio rerio)
Actinopterygii ncor1 35
  • 62.06 (n)
  • 62.78 (a)
zgc56355 35
ncor1 36
  • 59 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNT1 36
  • 16 (a)
OneToMany
SNT1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for NCOR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOR1 Gene

ENSEMBL:
Gene Tree for NCOR1 (if available)
TreeFam:
Gene Tree for NCOR1 (if available)

Paralogs for NCOR1 Gene

Paralogs for NCOR1 Gene

Pseudogenes.org Pseudogenes for NCOR1 Gene

genes like me logo Genes that share paralogs with NCOR1: view

Variants for NCOR1 Gene

Sequence variations from dbSNP and Humsavar for NCOR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs178652 -- 16,164,180(-) cactg(A/C)aacct intron-variant
rs178653 -- 16,162,163(-) aacaa(C/T)tatgt intron-variant
rs178654 -- 16,161,402(-) TGAGG(C/T)AGGAG intron-variant
rs178655 -- 16,161,220(-) tgtgt(G/T)tgCTT intron-variant
rs178656 -- 16,158,121(-) TGGCG(A/C)ATGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOR1 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv907706 CNV Gain 21882294
dgv3062n71 CNV Gain 21882294
nsv833377 CNV Loss 17160897
nsv522169 CNV Gain 19592680
dgv3063n71 CNV Loss 21882294
nsv907715 CNV Gain 21882294
esv2715708 CNV Deletion 23290073
nsv907716 CNV Loss 21882294
nsv907717 CNV Gain 21882294
nsv907718 CNV Loss 21882294
esv2661970 CNV Deletion 23128226
nsv528263 CNV Loss 19592680
nsv112235 CNV Loss 16902084

Variation tolerance for NCOR1 Gene

Residual Variation Intolerance Score: 0.651% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOR1 Gene

HapMap Linkage Disequilibrium report
NCOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR1 Gene

Disorders for NCOR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NCOR1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search NCOR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOR1

Genetic Association Database (GAD)
NCOR1
Human Genome Epidemiology (HuGE) Navigator
NCOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOR1
genes like me logo Genes that share disorders with NCOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR1 Gene

Publications for NCOR1 Gene

  1. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PMID: 9724795) Wang J. … Liu J.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman C.A. … Press M.F. (BMC Cancer 2009) 3 23
  3. Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor. (PMID: 19608741) Doyon G. … Boudreau F. (J. Biol. Chem. 2009) 3 23
  4. Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis. (PMID: 19048289) Tzelepi V. … Sotiropoulou-Bonikou G. (Virchows Arch. 2009) 3 23
  5. The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha. (PMID: 18052923) Choi K.C. … Yoon H.G. (Biochem. J. 2008) 3 23

Products for NCOR1 Gene

Sources for NCOR1 Gene

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