NCOR1 Gene
protein-coding GIFtS: 64
GCID: GC17M015933
|
|
nuclear receptor corepressor 1(Previous name: nuclear receptor co-repressor 1 )
| |
Aliases
for NCOR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Corepressor 11 2 | | KIAA10471 3 | | N-CoR1 2 3 | | N-CoR12 3 | | TRAC11 2 | | MGC1042161 | | HN-CoR1 | | HCIT529I101 | | Nuclear Receptor Co-Repressor 11 2 | | Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 12 |
Export aliases for NCOR1 gene to outside databasesPrevious GC identifers: GC17M016297 GC17M017045 GC17M015877 GC17M016135 GC17M015875 |
Summaries
for NCOR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCOR1:
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone andretinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. Itis part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeastprotein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions onchromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found onchromosomes 17 and 20.(provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histonedeacetylation and the formation of repressive chromatin structures which may impede the access of basal transcriptionfactors
Gene Wiki entry for NCOR1 (Nuclear receptor co-repressor 1)
|
Genomic Views
for NCOR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCOR1 gene promoter:
TBP Pax-5 AML1a AP-1 ATF-2 NF-kappaB Cart-1 c-Jun NF-kappaB1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCOR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2NCOR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M015933: view genomic region
(about GC identifiers)
Start:
|
15,933,408 bp from pter |
End:
|
16,121,499 bp from pter |
Size:
|
188,092 bases |
Orientation:
|
minus strand |
|
Proteins
for NCOR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376 (See
protein sequence)Recommended Name: Nuclear receptor corepressor 1 Size: 2440 amino acids; 270210 Da
Subunit: Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complexthat contains. SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and theretinoid acid receptors (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is faciliatedwith RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1,NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and KDM3A. Interacts with ZBTB33; the interactionserves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with HDAC9(via its catalytic domain). Interacts with CBFA2T3 and HEXIM1. Interacts (via the RRFD1 domain) with BAZ1A (via itsN-terminal); the interaction corepresses a number of NCOR1-regulated genes
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from  and Proteopedia  for NCOR1:2EQR (3D)
3H52 (3D)
3KMZ (3D)
3N00 (3D)
Secondary accessions: B3DLF8 Q9UPV5 Q9UQ18Alternative splicing: 2 isoforms: O75376-1 O75376-2 Explore the universe of human proteins at neXtProt for NCOR1: NX_O75376
Post-translational modifications:
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75376
NCOR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001177367.1 NP_001177369.1 NP_006302.2
ENSEMBL proteins: ENSP00000379192 ENSP00000268712 ENSP00000379190 ENSP00000461959 ENSP00000463169 ENSP00000462281 ENSP00000389839 ENSP00000379189 ENSP00000407998 ENSP00000462308 ENSP00000387727 ENSP00000462794 ENSP00000410784 ENSP00000379198 Reactome Protein details: O75376
Human Recombinant Protein Products for NCOR1:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
NCOR1 for ontologies About GeneDecksing
NCOR1 Antibody Products:
Assay Products for NCOR1: |
Protein
Domains /
Families
for NCOR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCOR1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75376ProtoNet protein and cluster: O75376 UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376Domain: The N-terminal region contains three independent domains that are capable of mediating transcriptionalrepression (RD1, RD2 and RD3)Domain: The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of whichcontains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding tounligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormonereceptor specificity (By similarity)Similarity: Belongs to the N-CoR nuclear receptor corepressors familySimilarity: Contains 2 SANT domains |
Function
for NCOR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCOR1_HUMAN, O75376Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histonedeacetylation and the formation of repressive chromatin structures which may impede the access of basal transcriptionfactors Genatlas biochemistry entry for NCOR1:nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatinremodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and SMS
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
NCOR1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for NCOR1:
14 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ncor1):
NCOR1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ncor1tm1Rsd for NCOR1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NCOR1 (NM_006311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR1 |
|
Pathways & Interactions
for NCOR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 3 | Transcription_Sin3 and NuRD in transcription regulation | | | 4 | Immune response_MIF-JAB1 signaling | | | 5 | Development_Notch Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 EMD Millipore Pathways for NCOR1 (see all 8)
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOR1
1 
Cell Signaling Technology (CST) Pathway for NCOR1
5/8  GeneGo (Thomson Reuters) Pathways for NCOR1 (see all 8)
5/10  BioSystems Pathways for NCOR1 (see all 10)
5/28 
Reactome Pathways for NCOR1 (see all 28)
NCOR1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/931 Interacting proteins for NCOR1 (O753761, 2, 3 ENSP000002687124) via UniProtKB, MINT, STRING, and/or I2D (see all 931)About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | -- | | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 7566114 |
NCOR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCOR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCOR1 for compounds About GeneDecksing
 Browse Tocris compounds for NCOR1
10/16 Novoseek chemical compound relationships for NCOR1 gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoid |
79 |
41 |
9111334 (1), 11435691 (1), 12840002 (1), 11054635 (1) (see all 34) |
| retinoic acid |
70.2 |
43 |
9171232 (3), 17519355 (2), 19416972 (2), 9531570 (2) (see all 24) |
| estrogen |
57.6 |
25 |
16141343 (6), 16195251 (3), 18521745 (2), 16309230 (1) (see all 9) |
| steroid |
54.6 |
27 |
17671682 (1), 19183483 (1), 9851803 (1), 18781912 (1) (see all 17) |
| vitamin d |
51.5 |
11 |
16141343 (1), 17855664 (1), 17519354 (1), 12716897 (1) (see all 5) |
| 4-hydroxytamoxifen |
50 |
1 |
17047084 (1) |
| mifepristone |
48.3 |
14 |
14744261 (3), 18852122 (3), 11162933 (1), 15355994 (1) (see all 6) |
| tamoxifen |
47.9 |
12 |
12684393 (3), 11162933 (1), 17407600 (1), 9501191 (1) (see all 9) |
| zinc |
39.4 |
5 |
9819405 (1), 10572087 (1), 12427969 (1), 15377655 (1) (see all 5) |
| testosterone |
33.8 |
6 |
14744261 (1), 16677694 (1), 15598662 (1), 16373395 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about NCOR1
|
Transcripts
for NCOR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCOR1 gene (3 alternative transcripts): NM_001190438.1 NM_001190440.1 NM_006311.3 Unigene Cluster for NCOR1: Nuclear receptor corepressor 1 Hs.462323 [show with all ESTs]Unigene Representative Sequence: NM_00631118/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000464381(uc002gpl.3) ENST00000470782(uc002gpm.3) ENST00000395851(uc002gpn.3 uc002gpp.1 uc002gpq.1)
ENST00000268712(uc010vwb.2 uc010coy.3 uc002gpo.3 uc010cpb.2 uc010coz.2 uc010cpa.2)
ENST00000580617 ENST00000395849 ENST00000582565 ENST00000579573 ENST00000580554
ENST00000579606 ENST00000583234 ENST00000458113(uc010vwc.2) ENST00000472189
ENST00000584872 ENST00000436068 ENST00000395848(uc002gpr.3) ENST00000583226
ENST00000411510
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOR1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NCOR1 (NM_006311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOR1 |
Additional cDNA sequence: AB028450.1 AB028451.1 AB028970.2 AF044209.1 AF087856.1 AF303584.1 AF303585.1 AF303586.1 AK295893.1 AK302746.1 AK307614.1 AK310405.1 AL137641.1 BC026028.1 BC035748.1 BC050594.2 BC056862.1 BC058511.1 BC068996.1 BC107772.1 BC142648.1 BC167431.1 24/32 DOTS entries (see all 32): DT.413437 DT.95225035 DT.91947143 DT.92379058 DT.95303359 DT.95307290 DT.91667181 DT.92457437 DT.97855793 DT.97855795 DT.101983946 DT.91971483 DT.92457355 DT.120903542 DT.40289536 DT.95260736 DT.102835647 DT.75140900 DT.120903520 DT.120903545 DT.120903614 DT.120903648 DT.301824 DT.75114142 24/358 AceView cDNA sequences (see all 358): CA413731 BE502011 CN482317 BF724401 AA826423 CB163130 AI378183 N53987 CB269102 BG677531 AL137641 F09793 AA641168 AV729453 BG768319 BF312695 CA428106 CR625140 BE218242 AI075296 AB028970 AI821208 AL134432 N69218
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCOR1
|
Expression
for NCOR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCOR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCTAAGTA
About this image
See NCOR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCOR1
SOURCE GeneReport for Unigene cluster: Hs.462323
SABiosciences Expression via Pathway-Focused PCR Arrays including NCOR1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR1 |
Orthologs
for NCOR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NCOR1 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NCOR11 |
nuclear receptor corepressor 1 |
79.27(n)
85.74(a) |
|
417598 XM_415843.3 XP_415843.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NCOR16 |
-- |
77(a) |
1 ↔ 1 |
AAWZ02036535(383-8436) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3983042 |
nuclear receptor corepressor |
76.34(n) |
|
AF495886.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc563552 |
similar to nuclear receptor co-repressor 1 |
73.19(n) |
|
393246 BC049302.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Smr6 |
Smrter |
12(a) |
1 → many |
X(12578236-12636477) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G522506 |
duplicated SANT DNA-binding domain-containing prot... |
9(a) |
1 → many |
3(19376138-19383100) |
rice
(Oryza sativa) |
Liliopsida |
-- |
MYB family transcription factor, putative, express... |
10(a) |
1 → many |
5(1501022-1507823) |
ENSEMBL Gene Tree for NCOR1 (if available)
TreeFam Gene Tree for NCOR1 (if available) |
Paralogs
for NCOR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCOR1 gene
- RCOR22 RCOR12 RCOR32 NCOR22
3 SIMAP similar genes for NCOR1 using alignment to 20 protein entries: NCOR1_HUMAN (see all proteins):DKFZp434M075 NCOR1P1 NCOR2
NCOR1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for NCOR1
PGOHUM00000259210 PGOHUM00000259634 PGOHUM00000263057 PGOHUM00000233298
|
Genomic Variants
for NCOR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCOR1 (15933408 - 16121499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NCOR1
4 CNVs: 39195 88360 5853 39196 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOR1 |
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Disorders
/ Diseases
for NCOR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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|
NCOR1 for disorders About GeneDecksing
OMIM gene information: 600849
OMIM disorders: --
20/31  diseases for NCOR1 (see all 31): About MalaCardsthyroiditis smith-magenis syndrome b-cell lymphomas acute promyelocytic leukemia
acute myeloid leukemia eaf fanconi's anemia huntington's disease
epithelial ovarian cancer myeloid leukemia endometrial carcinoma childhood leukemia
ovarian endometriosis squamous cell carcinoma leukemia endometriosis
ovarian cancer breast carcinoma carcinoma prostate cancer
10/13 Novoseek disease relationships for NCOR1 gene (see all 13) About this table
Human Genome Epidemiology (HuGE) Navigator: NCOR1 (8 documents)
Export disorders for NCOR1 gene to outside databases
|
Publications
for NCOR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCOR1 gene, integrated from 9 sources (see all 379):
(articles sorted by number of sources associating them with NCOR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PubMed id 9724795)1, 2, 3 Wang J.... Liu J.M. (1998)
- JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PubMed id 16024779)1, 2, 9 Zhang D.... Wong J. (2005)
- DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)1, 2, 9 Wu K.... Pestell R.G. (2003)
- Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PubMed id 17519354)1, 2, 9 Ewing A.K....Chakravarti D. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. (PubMed id 14527417)1, 2 Yoon H.-G.... Wong J. (2003)
- The histone deacetylase 9 gene encodes multiple protein isoforms. (PubMed id 12590135)1, 2 Petrie K....Zelent A. (2003)
- The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1, 2 Zhang J....Roeder R.G. (2002)
- ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. (PubMed id 11533236)1, 2 Amann J.M.... Hiebert S.W. (2001)
|
External Searches for NCOR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing NCOR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing NCOR1 gene
(According to HUGE)
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| |
Specialized Databases showing NCOR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NCOR1 gene:
Search GeneIP for patents involving NCOR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCOR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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