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NCOR1 Gene

protein-coding   GIFtS: 67
GCID: GC17M015933

Nuclear Receptor Corepressor 1

(Previous name: nuclear receptor co-repressor 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Corepressor 11 2     N-CoR12 3
Nuclear Receptor Co-Repressor 11 2     TRAC12
Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 11 2     hN-CoR2
N-CoR2 3     KIAA10473

External Ids:    HGNC: 76721   Entrez Gene: 96112   Ensembl: ENSG000001410277   OMIM: 6008495   UniProtKB: O753763   

Export aliases for NCOR1 gene to outside databases

Previous GC identifers: GC17M016297 GC17M017045 GC17M015877 GC17M016135 GC17M015875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCOR1 Gene:
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and
retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery.
It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the
yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical
regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene
are found on chromosomes 17 and 20.(provided by RefSeq, Jun 2010)

GeneCards Summary for NCOR1 Gene:
NCOR1 (nuclear receptor corepressor 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NCOR2.

UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376
Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes
histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal
transcription factors. Participates in the transcriptional repressor activity produced by BCL6

Gene Wiki entry for NCOR1 (Nuclear receptor co-repressor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCOR1 gene promoter:
         TBP   Pax-5   AML1a   AP-1   ATF-2   NF-kappaB   Cart-1   c-Jun   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCOR1 promoter sequence
   Search Chromatin IP Primers for NCOR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

NCOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M015933:  view genomic region     (about GC identifiers)

Start:
15,932,471 bp from pter      End:
16,121,499 bp from pter
Size:
189,029 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376 (See protein sequence)
Recommended Name: Nuclear receptor corepressor 1  
Size: 2440 amino acids; 270210 Da
Subunit: Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This
complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand.
Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor
repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2.
Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing
methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its
N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1,
HEXIM1, HDAC7, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1
Sequence caution: Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from and Proteopedia for NCOR1:
2EQR (3D)        3H52 (3D)        3KMZ (3D)        3N00 (3D)        4II6 (3D)    
Secondary accessions: B3DLF8 E9PGV6 Q86YY0 Q9UPV5 Q9UQ18
Alternative splicing: 3 isoforms:  O75376-1   O75376-2   O75376-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCOR1: NX_O75376

Explore proteomics data for NCOR1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys294
  • Modification sites at PhosphoSitePlus

  • See NCOR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177367.1  NP_001177369.1  NP_006302.2  

    ENSEMBL proteins: 
     ENSP00000268712   ENSP00000379192   ENSP00000379190   ENSP00000461959   ENSP00000474008  
     ENSP00000463169   ENSP00000462281   ENSP00000389839   ENSP00000379189   ENSP00000407998  
     ENSP00000462308   ENSP00000387727   ENSP00000462794   ENSP00000410784   ENSP00000379198  
    Reactome Protein details: O75376

    NCOR1 Human Recombinant Protein Products:

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    Novus Biologicals NCOR1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOR1

     
    Search eBioscience for Proteins for NCOR1 

     
    antibodies-online proteins for NCOR1 (3 products) 

     
    antibodies-online peptides for NCOR1

    NCOR1 Antibody Products:

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    ThermoFisher Antibody for NCOR1
    antibodies-online antibodies for NCOR1 (67 products) 

    NCOR1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NCOR1
    Cloud-Clone Corp. CLIAs for NCOR1
    Search eBioscience for ELISAs for NCOR1 
    antibodies-online kits for NCOR1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O75376

    ProtoNet protein and cluster: O75376

    UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376
    Domain: The N-terminal region contains three independent domains that are capable of mediating transcriptional
    repression (RD1, RD2 and RD3)
    Domain: The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of
    which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for
    binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise
    nuclear hormone receptor specificity (By similarity)
    Similarity: Belongs to the N-CoR nuclear receptor corepressors family
    Similarity: Contains 2 SANT domains


    Find genes that share domains with NCOR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOR1_HUMAN, O75376
    Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes
    histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal
    transcription factors. Participates in the transcriptional repressor activity produced by BCL6

         Genatlas biochemistry entry for NCOR1:
    nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2 complex,resulting in chromatin
    remodeling and repression of transcription,frequently deleted in malignant disorders,localized between CMT1A and
    SMS

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IPI19955185
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IMP12628926
         
    Find genes that share ontologies with NCOR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCOR1:
     Synthetic lethal with c-Myc af 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ncor1):
     adipose tissue  behavior/neurological  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with NCOR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ncor1tm1Rsd for NCOR1

       genOway: Develop your customized and physiologically relevant rodent model for NCOR1

    miRNA
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    miRTarBase miRNAs that target NCOR1:
    hsa-mir-615-3p (MIRT040375), hsa-mir-484 (MIRT041973), hsa-mir-320a (MIRT044744), hsa-let-7b-5p (MIRT052038), hsa-mir-1301-3p (MIRT036031)

    Block miRNA regulation of human, mouse, rat NCOR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCOR1 (see all 74):
    hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-3916 hsa-miR-93 hsa-miR-149 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidNCOR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NCOR1
    Predesigned siRNA for gene silencing in human, mouse, rat NCOR1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for NCOR1 (see all 11)
    OriGene ORF clones in mouse, rat for NCOR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NCOR1 (NM_006311)
    Sino Biological Human cDNA Clone for NCOR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOR1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NCOR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NCOR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCOR1_HUMAN, O75376: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA18326024
    GO:0000790nuclear chromatin IDA17505061
    GO:0005634nucleus IDA10049357
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with NCOR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCOR1 About   (see all 36)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50
    5Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    RORA Activates Circadian Expression0.88


    Find genes that share SuperPaths with NCOR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NCOR1
        Notch Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NCOR1
        Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Huntington's Disease Pathway
    Macrophage Differentiation and Growth Inhibition by METS

    1 Cell Signaling Technology (CST) Pathway for NCOR1
        Chromatin Regulation / Acetylation

    Selected GeneGo (Thomson Reuters) Pathways for NCOR1 (see all 8)
        Transcription Androgen Receptor nuclear signaling
    Signal transduction Activin A signaling regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription PPAR Pathway
    Immune response MIF-JAB1 signaling

    Selected BioSystems Pathways for NCOR1 (see all 10)
        Adipogenesis
    Ovarian Infertility Genes
    Androgen receptor signaling pathway
    Delta-Notch Signaling Pathway
    ErbB4 signaling events


    Selected Reactome Pathways for NCOR1 (see all 13)
        NOTCH1 Intracellular Domain Regulates Transcription
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Transcriptional activation of mitochondrial biogenesis


    2 Kegg Pathways  (Kegg details for NCOR1):
        Thyroid hormone signaling pathway
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOR1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCOR1 (O753761, 2, 3 ENSP000002687124) via UniProtKB, MINT, STRING, and/or I2D (see all 1028)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0002361CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter TAS7566114

    Find genes that share ontologies with NCOR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCOR1

    Selected Novoseek inferred chemical compound relationships for NCOR1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 79 41 9111334 (1), 11435691 (1), 12840002 (1), 11054635 (1) (see all 34)
    retinoic acid 70.2 43 9171232 (3), 17519355 (2), 19416972 (2), 9531570 (2) (see all 24)
    estrogen 57.6 25 16141343 (6), 16195251 (3), 18521745 (2), 16309230 (1) (see all 9)
    steroid 54.6 27 17671682 (1), 19183483 (1), 9851803 (1), 18781912 (1) (see all 17)
    vitamin d 51.5 11 16141343 (1), 17855664 (1), 17519354 (1), 12716897 (1) (see all 5)
    4-hydroxytamoxifen 50 1 17047084 (1)
    mifepristone 48.3 14 14744261 (3), 18852122 (3), 11162933 (1), 15355994 (1) (see all 6)
    tamoxifen 47.9 12 12684393 (3), 11162933 (1), 17407600 (1), 9501191 (1) (see all 9)
    zinc 39.4 5 9819405 (1), 10572087 (1), 12427969 (1), 15377655 (1) (see all 5)
    testosterone 33.8 6 14744261 (1), 16677694 (1), 15598662 (1), 16373395 (1) (see all 5)



    Find genes that share compounds with NCOR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCOR1 gene (3 alternative transcripts): 
    NM_001190438.1  NM_001190440.1  NM_006311.3  

    Unigene Cluster for NCOR1:

    Nuclear receptor corepressor 1
    Hs.462323  [show with all ESTs]
    Unigene Representative Sequence: NM_006311
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000268712(uc010vwb.2 uc010coy.3 uc002gpo.3 uc010cpb.2 uc010coz.2 uc010cpa.2)
    ENST00000464381(uc002gpl.3) ENST00000470782(uc002gpm.3) ENST00000395851(uc002gpn.3 uc002gpp.1 uc002gpq.1)
    ENST00000580617 ENST00000395849 ENST00000582565 ENST00000579573 ENST00000603989
    ENST00000580554 ENST00000579606 ENST00000583234 ENST00000458113(uc010vwc.2)
    ENST00000472189 ENST00000584872 ENST00000436068 ENST00000395848(uc002gpr.3)
    ENST00000583226
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCOR1 (see all 74):
    hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-3916 hsa-miR-93 hsa-miR-149 hsa-miR-29a*
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    GenScript: all cDNA clones in your preferred vector (see all 3): NCOR1 (NM_006311)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOR1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NCOR1
      QuantiFast Probe-based Assays in human, mouse, rat NCOR1

    Additional mRNA sequence: 

    AB028450.1 AB028451.1 AB028970.2 AF044209.1 AF087856.1 AF303584.1 AF303585.1 AF303586.1 
    AK295893.1 AK302746.1 AK307614.1 AK310405.1 AL137641.1 BC026028.1 BC035748.1 BC050594.2 
    BC056862.1 BC058511.1 BC068996.1 BC107772.1 BC142648.1 BC167431.1 

    Selected DOTS entries (see all 32):

    DT.413437  DT.95225035  DT.91947143  DT.92379058  DT.95303359  DT.95307290  DT.91667181  DT.92457437 
    DT.97855793  DT.97855795  DT.101983946  DT.91971483  DT.92457355  DT.120903542  DT.40289536  DT.95260736 
    DT.102835647  DT.75140900  DT.120903520  DT.120903545  DT.120903614  DT.120903648  DT.301824  DT.75114142 

    Selected AceView cDNA sequences (see all 358):

    BG614811 AI821208 AL134432 AA505080 Z39406 AI686485 AI245620 BM806738 
    AI769699 BM738055 BM672220 AA232898 BC058511 F08119 CB105322 AW271196 
    CB269102 BE670027 BF724401 AA641168 AA676477 BE644673 BG768319 CR625140 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
    SP1:                                                                                                                          -                       -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46
    SP1:                                                  -                                                     -                                                   
    SP2:                                                  -                                         -           -                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NCOR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NCOR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTAAGTA
    NCOR1 Expression
    About this image


    NCOR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    NCOR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCOR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462323
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOR1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NCOR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCOR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NCOR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncor11 , 5 nuclear receptor co-repressor 11, 5 89.11(n)1
    92.78(a)1
      11 (38.08 cM)5
    201851  NM_001252313.11  NP_001239242.11 
     623164265 
    chicken
    (Gallus gallus)
    Aves NCOR11 nuclear receptor corepressor 1 79.18(n)
    85.53(a)
      417598  XM_004946658.1  XP_004946715.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCOR16
    nuclear receptor corepressor 1
    77(a)
    1 ↔ 1
    AAWZ02036535(383-20175)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983042 nuclear receptor corepressor 76.34(n)    AF495886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563552 similar to nuclear receptor co-repressor 1 73.19(n)   393246  BC049302.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNT1(YCR033W)4 Subunit of the Set3C deacetylase complex that interacts more   --   3(186489-190169) 850399  NP_009962.2 


    ENSEMBL Gene Tree for NCOR1 (if available)
    TreeFam Gene Tree for NCOR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCOR1 gene
    NCOR22  
    3 SIMAP similar genes for NCOR1 using alignment to 20 protein entries:     NCOR1_HUMAN (see all proteins):
    DKFZp434M075    NCOR1P1    NCOR2

    Find genes that share paralogs with NCOR1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for NCOR1
    PGOHUM00000259210 PGOHUM00000259634 PGOHUM00000263057 PGOHUM00000233298


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCOR1 (see all 4181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159463291,2
    C,F--15933268(+) CTATAC/TGGTTG 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1493225601,2
    C--15933383(+) GACCA-/GAAGTC 2 -- ds50010--------
    rs1168159991,2
    C,F--15933480(+) ATGTTT/CGTTAA 2 -- ut311Minor allele frequency- C:0.09WA 118
    rs1834457971,2
    --15933575(+) TTGAAC/TAGGCT 2 -- ut310--------
    rs1149187581,2
    C,F--15933579(+) ATAGGC/GTGAGG 2 -- ut311Minor allele frequency- G:0.07WA 118
    rs1479883511,2
    C--15933916(+) CCAAC-/TTT   
       CCAAG
    TTTCC
    2 -- ut310--------
    rs129524661,2
    C--15934025(+) TGAAGA/CCAAAT 2 -- ut311Minor allele frequency- C:0.00NA 2
    rs1485513251,2
    C--15934127(+) AGTGAC/TAGGAG 2 -- ut310--------
    rs1881460771,2
    C--15934134(+) GGAGGC/GTCTTG 2 -- ut310--------
    rs1421256771,2
    --15934253(+) GATCTA/GTTTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NCOR1 (15932471 - 16121499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NCOR1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715702CNV Deletion23290073
    esv2661970CNV Deletion23128226
    esv2715708CNV Deletion23290073
    nsv907718CNV Loss21882294
    nsv833377CNV Loss17160897
    nsv112235CNV Loss16902084
    nsv528263CNV Loss19592680
    nsv907716CNV Loss21882294
    dgv3063n71CNV Loss21882294
    dgv3062n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCOR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600849    OMIM disorders: --


    Find genes that share disorders with NCOR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NCOR1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 66.5 2 17699721 (1), 17047052 (1)
    promyelocytic leukemia 50.2 1 10572087 (1)
    breast cancer 46.3 21 15788656 (2), 16195251 (2), 18521745 (2), 16019133 (2) (see all 15)
    leukemogenesis 44.5 2 14701861 (1)
    endometrial hyperplasia 23.9 2 14601091 (2)
    prostate cancer 21.2 5 16886664 (2), 14744261 (1), 16373395 (1)
    endometrial carcinoma 16.1 1 14751175 (1)
    cancer 2.78 2 16886664 (1)
    carcinoma ductal 0.608 2 10690532 (2)
    huntington disease 0.183 1 10441327 (1)

    Genetic Association Database (GAD): NCOR1
    Human Genome Epidemiology (HuGE) Navigator: NCOR1 (8 documents)

    Export disorders for NCOR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCOR1 gene, integrated from 10 sources (see all 403):
    (articles sorted by number of sources associating them with NCOR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PubMed id 9724795)1, 2, 3 Wang J.... Liu J.M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PubMed id 16024779)1, 2, 9 Zhang D.... Wong J. (Mol. Cell. Biol. 2005)
    3. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)1, 2, 9 Wu K.... Pestell R.G. (J. Biol. Chem. 2003)
    4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (BMC Cancer 2009)
    5. Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PubMed id 17519354)1, 2, 9 Ewing A.K.... Chakravarti D. (Mol. Endocrinol. 2007)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Nuclear receptor coregulator SNP discovery and impact on breast cancer risk. (PubMed id 20003447)1, 4 Hartmaier R.J....Oesterreich S. (BMC Cancer 2009)
    8. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    9. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9611 HGNC: 7672 AceView: NCOR1 Ensembl:ENSG00000141027 euGenes: HUgn9611
    ECgene: NCOR1 Kegg: 9611 H-InvDB: NCOR1

    (According to HUGE)
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    HUGE: KIAA1047

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NCOR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCOR1 gene:
    Search GeneIP for patents involving NCOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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