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NCOR1 Gene

protein-coding GIFtS: 63

GC17M015875

nuclear receptor co-repressor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1047 ^¹, ², ³
MGC104216 ^¹, ²
N-CoR ^¹, ², ³
N-CoR1 ^³
TRAC1 ^¹, ²
hCIT529I10 ^¹, ²
hN-CoR ^¹, ²

Descriptions
nuclear receptor co-repressor 1 ^²
thyroid hormone- and retinoic acid receptor-associated corepressor 1 ^²

External Ids
HGNC: 7672¹
Entrez Gene: 9611²
UniProtKB: O75376³
Ensembl: ENSG00000141027⁷

Search outside databases for aliases for NCOR1 gene

Previous GC identifers: GC17M016297 GC17M017045 GC17M015877 GC17M016135

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NCOR1:

This gene encodes a protein that mediates ligand-independent transcription repression of

thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing

access of the transcription machinery. It is part of a complex which also includes histone

deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is

located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome

17. An alternatively spliced transcript variant has been described, but its full length sequence

has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376

Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which

promotes histone deacetylation and the formation of repressive chromatin structures which may

impede the access of basal transcription factors

Gene Wiki entry for NCOR1 (Nuclear_receptor_co-repressor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NCOR1 gene

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

NCOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M015875: (about GC identifiers)

Start:	15,875,443 bp from pter
End:	16,059,570 bp from pter
Size:	184,128 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376 (See protein sequence)

Recommended Name: Nuclear receptor corepressor 1

Size: 2440 amino acids; 270210 Da

Subunit: Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large

corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex

associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand.

Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2,

HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with

ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions

containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts

with CBFA2T3 and HEXIM1. Interacts with C1D (By similarity)

Subcellular location: Nucleus (By similarity)

PDB structures from and Proteopedia :

2EQR (3D)

Secondary accessions: Q9UPV5 Q9UQ18

Alternative splicing: 2 isoforms: O75376-1 O75376-2

Post-translational modifications:

Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006302.2

ENSEMBL proteins:

ENSP00000379190 ENSP00000379192 ENSP00000379198 ENSP00000379189 ENSP00000379187 ENSP00000268712

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nuclear Receptor Corepressor NCoR)
	Human Recombinant Proteins from Abnova (NCOR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for NCOR1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NCOR1
	Sigma-Aldrich Antibodies for NCOR1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Nuclear Receptor Corepressor NCoR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NCOR1)
	Novus Biologicals Antibodies for NCOR1

Assays for NCOR1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of NCOR1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O75376

ProtoNet protein and cluster: O75376

UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376

Domain: The N-terminal region contains three independent domains that are capable of mediating

transcriptional repression (RD1, RD2 and RD3)

Domain: The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and

ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is

necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences

flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity)

Similarity: Belongs to the N-CoR nuclear receptor corepressors family

Similarity: Contains 2 SANT domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOR1)
		Millipore RNAi Products for the Analysis of NCOR1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (NCOR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006311

Applied Biosystems Silencer® siRNAs for NCOR1

Sigma-Aldrich siRNA for NCOR1

Sigma-Aldrich shRNA for NCOR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006311
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006311
untagged cDNA clone in CMV expression vector: NM_006311

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006311

UniProtKB/Swiss-Prot: NCOR1_HUMAN, O75376

Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which

promotes histone deacetylation and the formation of repressive chromatin structures which may

impede the access of basal transcription factors

Genatlas biochemistry entry for NCOR1:

nuclear receptor co-repressor 1,homolog to SMRT,recruiting the CoR/Sin3/HDAC1/HDAC2

complex,resulting in chromatin remodeling and repression of transcription,frequently deleted in

malignant disorders,localized between CMT1A and SMS

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ncor1):

adipose tissue	behavior/neurological	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	liver/biliary system	nervous system
no phenotypic analysis	skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003714	transcription corepressor activity	TAS	7566114
GO:0019904	protein domain specific binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for NCOR1 (Your Favorite Gene powered by Ingenuity) (see all 9 )

PPAR&alpha
PPAR Signaling
Huntington's Disease Signaling
Glucocorticoid Receptor Signaling
RAR Activation

GeneDecks NCOR1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for NCOR1

5/147 Interacting proteins for NCOR1 (O75376^{1, 2} ENSP00000268712³) via UniProtKB, MINT, and/or STRING (see all 147 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR2E3	Q9Y5X4², ENSP00000317199³	MINT-4303731 MINT-4303443 STRING (score=.951)
HDAC9	Q9UKV0¹, ENSP00000262069³	EBI-347233, EBI-765444 STRING (score=.997)
RBBP7	Q16576², ENSP00000369424³	MINT-4303604 STRING (score=.99)
SKI	P12755¹, ENSP00000367797³	EBI-347233, EBI-347281 STRING (score=.988)
ZMYND11	Q15326², ENSP00000370996³	MINT-2735454 STRING (score=.981)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	TAS	7566114
GO:0016568	chromatin modification	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NCOR1
6 Novoseek chemical compound relationships for NCOR1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	55.16	26	17671682 (1), 19183483 (1), 9851803 (1), 18781912 (1) (see all 16)
zinc	37.41	5	9819405 (1), 10572087 (1), 12427969 (1), 15377655 (1) (see all 5)
progesterone	31.28	3	17571860 (1), 15857753 (1), 18521745 (1)
triiodothyronine	24.88	2	16712523 (1), 14601091 (1)
estradiol	9.46	2	16608856 (1), 17047084 (1)
cyclic amp	1.85	1	15525597 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOR1)
		Millipore RNAi Products for the Analysis of NCOR1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (NCOR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006311

Sigma-Aldrich siRNA for NCOR1

Sigma-Aldrich shRNA for NCOR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006311

REFSEQ mRNAs for NCOR1 gene:

NM_006311.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006311

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006311
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006311
                                 untagged cDNA clone in CMV expression vector: NM_006311

Additional cDNA sequence:

AB028450.1 AB028451.1 AB028970.2 AF044209.1 AF087856.1 AF303584.1 AF303585.1 AF303586.1

AK295893.1 AK302746.1 AK307614.1 AK310405.1 AL137641.1 BC026028.1 BC035748.1 BC050594.2

BC056862.1 BC058511.1 BC068996.1 BC107772.1 BC142648.1 BC167431.1 CR625140.1

24/30 DOTS entries (see all 30 ):

DT.413437 DT.95225035 DT.91947143 DT.92379058 DT.95303359 DT.95307290 DT.92457437 DT.97855793

DT.97855795 DT.101983946 DT.92457355 DT.91971483 DT.120903542 DT.95226122 DT.40289536 DT.95260736

DT.102835647 DT.75140900 DT.120903520 DT.120903545 DT.120903614 DT.120903648 DT.75144676 DT.91922173

24/358 AceView cDNA sequences (see all 358 ):

BX100657 AA346710 BM693946 BM825002 AI671770 BF312695 BU608885 AV729453

AA641168 BQ230077 BE502011 BM459944 CB105322 BE514943 CB163130 N53987

AI821208 CN482317 AA505083 CB269102 AI568614 BE670027 AI769699 AA505080

highest scoring ESTs for NCOR1:

BE909309 BF303805 BF666907 BF683644 BG505814 BG722872 BI763091 BI918410 BM559162 BM802851

Unigene Cluster for NCOR1:

Nuclear receptor co-repressor 1

Hs.462323 [show with all ESTs]

Unigene Representative Sequence: AF087856

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NCOR1

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23	^
SP1:																																									-								-
SP2:																																																	-
SP3:
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36	^	37a	·	37b	^	38	^	39a	·	39b	^	40	^	41	^	42	^	43	^	44	^	45	^	46
SP1:																	-																		-
SP2:																	-														-				-
SP3:
SP4:																																			-
SP5:

About this scheme

ECgene alternative splicing isoforms for NCOR1

6 Ensembl transcripts including schematic representations:

ENST00000395849 ENST00000395851 ENST00000395857 ENST00000395848 ENST00000395846 ENST00000268712

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NCOR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NCOR1

¹ / ² / ³

7 probe-sets matching NCOR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75470_at²^{, 3}	U95-D	2	1.00	0.97	1.00	1.00	AI732192	0.60	1.00	0.82	1
234313_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB028451	0.40	1.00	0.76	1
200854_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB028970	0.60	0.75	0.68	1
200857_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006311	0.60	1.00	0.82	1
234313_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200854_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200857_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NCOR1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCCTAAGTA

SOURCE GeneReport for Unigene cluster: Hs.462323
Expression variation in blood from EXPOLDB for NCOR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NCOR1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NCOR1¹	--	nuclear receptor co-repressor 1	91.71(n) 95.03(a)	479515 XM_846392.1 XP_851485.1
chimpanzee (Pan troglodytes)	NCOR1¹	--	nuclear receptor co-repressor 1	81.82(n) 75(a)	741384 XM_001153894.1 XP_001153894.1
cow (Bos taurus)	NCOR1¹	--	nuclear receptor co-repressor 1	85.71(n) 91.29(a)	507663 XM_866711.2 XP_871804.2
mouse (Mus musculus)	Ncor1^{1, 5}	11⁵	nuclear receptor co-repressor 1^{1, 5}	89.23(n)¹ 92.82(a)¹	20185¹ NM_011308.2¹ NP_035438.2¹ AB093281⁵ AK013831⁵ (see all 32)
chicken (Gallus gallus)	NCOR1¹	--	nuclear receptor co-repressor 1	79.27(n) 85.74(a)	417598 XM_415843.2 XP_415843.2

About this table Species with no ortholog for NCOR1

ENSEMBL Gene Tree for NCOR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NCOR1 gene

C20orf191² NCOR2² ENSG00000205203²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/825 NCBI SNPs in NCOR1 are shown (see all 825 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 135)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3205089^1,2	C,F,H	15883636(-)	`GCTGGA/TAGACA`	1	E/V	mis¹ ese³		9	MN EU EA WA	1016
	rs12942684^1,2	H	15905490(+)	`CCTTGT/GCCGAG`	1	A/D	mis¹ ese³		4	EU EA WA	420
	rs7210057^1,2	F,H	15909612(+)	`ATCTGT/CTGTGA`	1	Q/Q	syn¹ ese³		4	EU EA WA	420
	rs2157991^1,2	A,C,F,H,O	15902676(-)	`TTTCCT/CGGGAT`	1	--	int¹		7	EU EA WA NA	562
	rs1079533^1,2	A,C,F,H,O	15890923(-)	`GTTGCC/TTCTCC`	1	--	int¹		14	EA NA EU WA	1112
	rs178657^1,2	A,C,F,H,O	15998658(-)	`AGTAAT/CATCCC`	1	--	int¹		5	MN EU EA WA	596
	rs2051736^1,2	A,C,F,H,O	15930738(-)	`TAAGCA/GGAAGT`	1	--	int¹		15	NS MN EU EA WA NA	2548
	rs1126148^1,2	A,C,F,H,O	15956304(-)	`ACTGAC/TAAGAT`	1	--	int¹		10	MN EU EA WA NA	914
	rs1073094^1,2	A,C,F,H,O	15904174(+)	`GAAGGT/CTCTCA`	1	--	int¹		15	NA EA NS EU WA	886
	rs178838^1,2	A,C,F,H,O	16016626(-)	`TTTCTA/TTGTAG`	1	--	int¹ trp³		17	EA NA MN EU WA	1386

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HapMap Linkage Disequilibrium images for NCOR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600849

10/13 Novoseek disease relationships for NCOR1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	67.63	2	17699721 (1), 17047052 (1)
promyelocytic leukemia	51.53	1	10572087 (1)
leukemogenesis	46.08	2	14701861 (1)
breast cancer	45.82	20	15788656 (2), 16195251 (2), 18521745 (2), 16019133 (2) (see all 14)
endometrial hyperplasia	25.54	2	14601091 (2)
prostate cancer	23.54	5	16886664 (2), 14744261 (1), 16373395 (1)
endometrial carcinoma	17.90	1	14751175 (1)
carcinoma ductal	2.74	2	10690532 (2)
huntington disease	2.30	1	10441327 (1)
cancer	0.00	2	16886664 (1)

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Human Genome Epidemiology Navigator: NCOR1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/269 PubMed articles for NCOR1 gene (see all 269 ):

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. (PubMed id 9724795)^{2, 3, 4} Wang J....Liu J.M. (1998)
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PubMed id 16024779)^{1, 3, 4} Zhang D.... Wong J. (2005)
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)^{1, 3, 4} Wu K.... Pestell R.G. (2003)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. (PubMed id 14527417)^{3, 4} Yoon H.-G.... Wong J. (2003)
The histone deacetylase 9 gene encodes multiple protein isoforms. (PubMed id 12590135)^{3, 4} Petrie K....Zelent A. (2003)
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)^{3, 4} Zhang J....Roeder R.G. (2002)
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. (PubMed id 11533236)^{3, 4} Amann J.M.... Hiebert S.W. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9611	HGNC: 7672	AceView: NCOR1	Ensembl:ENSG00000141027	euGenes: HUgn9611
ECgene: NCOR1	H-InvDB: NCOR1

(According to HUGE)
About This Section

HUGE: KIAA1047

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NCOR1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NCOR1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NCOR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NCOR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NCOR1		Antibodies for NCOR1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NCOR1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NCOR1)
	Antibodies (NCOR1)
	Chimera RNAi (NCOR1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Nuclear Receptor Corepressor NCoR)
	Antibodies (Nuclear Receptor Corepressor NCoR)

Search OriGene for NCOR1

Search Tocris compounds for NCOR1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NCOR1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NCOR1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

NCOR1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for NCOR1

Summaries
for NCOR1

Genomic Location
for NCOR1

Proteins
for NCOR1

Protein Domains/
Families
for NCOR1

Gene Function
for NCOR1

Pathways & Interactions
for NCOR1

Drugs & Compounds
for NCOR1

Transcripts
for NCOR1

Expression
for NCOR1

Orthologs
for NCOR1

Paralogs
for NCOR1

SNPs/Variants
for NCOR1

Disorders & Mutations
for NCOR1

Medical News
for NCOR1

Publications
for NCOR1

Search for NCOR1

Genome Databases showing NCOR1

Other Databases showing NCOR1

Specialized Databases showing NCOR1

Licensable Technologies
for NCOR1

Services
for NCOR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NCOR1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor NCOR1

Summariesfor NCOR1

Genomic Locationfor NCOR1

Proteinsfor NCOR1

Protein Domains/Familiesfor NCOR1

Gene Functionfor NCOR1

Pathways & Interactionsfor NCOR1

Drugs & Compoundsfor NCOR1

Transcriptsfor NCOR1

Expression for NCOR1

Orthologsfor NCOR1

Paralogsfor NCOR1

SNPs/Variantsfor NCOR1

Disorders & Mutationsfor NCOR1

Medical Newsfor NCOR1

Publicationsfor NCOR1

Search for NCOR1

Genome Databases showing NCOR1

Other Databases showing NCOR1

Specialized Databases showing NCOR1

Licensable Technologiesfor NCOR1

Servicesfor NCOR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NCOR1

Summaries
for NCOR1

Genomic Location
for NCOR1

Proteins
for NCOR1

Protein Domains/
Families
for NCOR1

Gene Function
for NCOR1

Pathways & Interactions
for NCOR1

Drugs & Compounds
for NCOR1

Transcripts
for NCOR1

Expression
for NCOR1

Orthologs
for NCOR1

Paralogs
for NCOR1

SNPs/Variants
for NCOR1

Disorders & Mutations
for NCOR1

Medical News
for NCOR1

Publications
for NCOR1

Licensable Technologies
for NCOR1

Services
for NCOR1