Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA7 Gene

protein-coding   GIFtS: 50
GCID: GC06P126102

nuclear receptor coactivator 7

 Explore 5 diseases affiliated with
NCOA7 via our new
 Human Malady Compendium 
Biological research products
for NCOA7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Receptor Coactivator 71 2     Nbla000522
ERAP1401 2 3 5     Nbla109932
DJ187J11.31     Estrogen Receptor Associated Protein 140 KDa2
Estrogen Nuclear Receptor Coactivator 12 3     Putative Protein Product Of Nbla000522
140 KDa Estrogen Receptor-Associated Protein2 3     Putative Protein Product Of Nbla109932
ESNA12 3     

External Ids:    HGNC: 210811   Entrez Gene: 1351122   Ensembl: ENSG000001119127   OMIM: 6097525   UniProtKB: Q8NI083   

Export aliases for NCOA7 gene to outside databases

Previous GC identifers: GC06P126037 GC06P126082 GC06P126144 GC06P123687


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NCOA7_HUMAN, Q8NI08
Function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of
different nuclear receptors, such as ESR1, THRB, PPARG and RARA

Gene Wiki entry for NCOA7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA7 gene promoter:
         AhR   AP-1   FOXD1   POU3F2 (N-Oct-5b)   AP-4   Arnt   C/EBPalpha   Egr-2   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCOA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCOA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32   Ensembl cytogenetic band:  6q22.32   HGNC cytogenetic band: 6q22.33

NCOA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P126102:  view genomic region     (about GC identifiers)

Start:
126,102,307 bp from pter      End:
126,252,266 bp from pter
Size:
149,960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCOA7_HUMAN, Q8NI08 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 7  
Size: 942 amino acids; 106162 Da
Subunit: Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the
heterodimer AHR-ARNT
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAD89948.1; Type=Frameshift; Positions=782;
Secondary accessions: B2RNS2 B7Z2C4 B9EH71 G8JL91 Q3LID6 Q4G0V1 Q5TF95 Q6IPQ4 Q6NE83 Q86T89 Q8N1W4
Alternative splicing: 7 isoforms:  Q8NI08-1   Q8NI08-2   Q8NI08-3   Q8NI08-4   Q8NI08-5   Q8NI08-6   Q8NI08-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCOA7: NX_Q8NI08

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NI08

  • NCOA7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001116314.1  NP_001186548.1  NP_001186549.1  NP_001186550.1  NP_001186551.1  NP_861447.3  

    ENSEMBL proteins: 
     ENSP00000357341   ENSP00000403643   ENSP00000406363   ENSP00000407426   ENSP00000408211  
     ENSP00000389186   ENSP00000411002   ENSP00000402468   ENSP00000398268   ENSP00000407684  
     ENSP00000376269   ENSP00000229634  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NCOA7
    OriGene Custom Protein Services for NCOA7 
    GenScript Custom Purified and Recombinant Proteins Services for NCOA7
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NCOA7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--


    NCOA7 for ontologies           About GeneDecksing



    NCOA7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NCOA7 
    GenScript Custom Superior Antibodies Services for NCOA7
    Novus Biologicals NCOA7 Antibodies
    Search for Antibodies for NCOA7 at Abcam  
    Uscn Antibodies for NCOA7
    ThermoFisher Antibody for NCOA7

    Assay Products for NCOA7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCOA7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NCOA7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NCOA7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018392 Peptidoglycan-bd_lysin
     IPR002482 Peptidoglycan-bd_Lysin_subgr
     IPR006571 TLDc
     IPR004182 GRAM

    Graphical View of Domain Structure for InterPro Entry Q8NI08

    ProtoNet protein and cluster: Q8NI08

    2 Blocks protein families:
    IPB002482 Peptidoglycan-binding LysM
    IPB004182 GRAM domain


    UniProtKB/Swiss-Prot: NCOA7_HUMAN, Q8NI08
    Similarity: Belongs to the OXR1 family
    Similarity: Contains 1 LysM repeat
    Similarity: Contains 1 TLD domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NCOA7_HUMAN, Q8NI08
    Function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of
    different nuclear receptors, such as ESR1, THRB, PPARG and RARA

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): NCOA7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA7
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA7 (see all 95):
    hsa-miR-579 hsa-miR-3938 hsa-miR-520e hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-342-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNCOA7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOA7 (see all 4)
    OriGene shRNA RFP: NCOA7
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOA7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCOA7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): NCOA7 (NM_001199621)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NCOA7
    Search LifeMap BioReagents cell lines for NCOA7

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA7

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IDA11971969
    GO:0035257nuclear hormone receptor binding IDA11971969


    NCOA7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1AHR Pathway
    AHR Pathway1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NCOA7
        AHR Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for NCOA7 (Q8NI081, 3 ENSP000003573414) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHRP358691, 3, ENSP000002420574EBI-80799,EBI-80780 I2D: score=1 STRING: ENSP00000242057
    GABARAPO951661, 3EBI-80799,EBI-712001 I2D: score=3 
    GABARAPL1Q9H0R81, 3EBI-80799,EBI-3240381 I2D: score=2 
    ARNTP275401, 3, ENSP000003514074EBI-80799,EBI-80809 I2D: score=1 STRING: ENSP00000351407
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016998cell wall macromolecule catabolic process IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA11971969


    NCOA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCOA7
    Search CenterWatch for drugs/clinical trials and news about NCOA7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCOA7 gene (6 alternative transcripts): 
    NM_001122842.2  NM_001199619.1  NM_001199620.1  NM_001199621.1  NM_001199622.1  NM_181782.4  

    Unigene Cluster for NCOA7:

    Nuclear receptor coactivator 7
    Hs.171426  [show with all ESTs]
    Unigene Representative Sequence: NM_001199620
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368357(uc010kes.3 uc003qae.4) ENST00000453302 ENST00000417494
    ENST00000428318 ENST00000487635(uc003qaj.3) ENST00000419660 ENST00000413085
    ENST00000433571 ENST00000448104 ENST00000438495(uc003qak.3) ENST00000444128
    ENST00000392477(uc003qaf.3 uc003qag.3 uc003qah.3 uc003qai.3 uc010ket.3)
    ENST00000229634

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): NCOA7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA7
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA7 (see all 95):
    hsa-miR-579 hsa-miR-3938 hsa-miR-520e hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-342-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNCOA7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOA7 (see all 4)
    OriGene shRNA RFP: NCOA7
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOA7
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): NCOA7 (NM_001199621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA7 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOA7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA7

    Additional cDNA sequence: 

    AB074156.1 AF493978.1 AJ420542.1 AK094706.1 AK127512.1 AK294558.1 AK307395.1 AL832621.2 
    AL832628.2 AL834442.1 AY364254.1 BC009399.2 BC033612.1 BC039853.1 BC071782.1 BC137094.1 
    BC137095.1 BX537385.1 

    16 DOTS entries:

    DT.443898  DT.100818615  DT.101984130  DT.95159186  DT.95159187  DT.95100047  DT.100818616  DT.40193940 
    DT.95323840  DT.121338514  DT.121338542  DT.100818614  DT.40229034  DT.40313541  DT.91785426  DT.99999305 

    24/180 AceView cDNA sequences (see all 180):

    BM980857 AA588025 F02660 BE673183 AW593500 BM264079 BC036461 BM976079 
    BC071782 BC039853 CN482588 CD238111 BF002319 AW778883 AI621035 AI681311 
    CD677634 AL832621 CB117168 BF594619 AI745670 BQ003857 AI536560 AW004797 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                    -     -     -     -                                                     -                             -     -                 -         
    SP2:                                      -                                                     -     -                       -     -                 -         
    SP3:                                      -                                                     -                             -     -                 -         
    SP4:                                      -                                                                                                                     
    SP5:                                      -           -     -                                   -     -                                                         

    ExUns: 18b ^ 19 ^ 20a · 20b · 20c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for NCOA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NCOA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA7

    SOURCE GeneReport for Unigene cluster: Hs.171426

    UniProtKB/Swiss-Prot: NCOA7_HUMAN, Q8NI08
    Tissue specificity: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach,
    bladder, spinal cord and pancreas. Expressed in cancer cell line

        SABiosciences Custom PCR Arrays for NCOA7
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOA7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCOA7 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NCOA71 nuclear receptor coactivator 7 71.06(n)
    69.53(a)
      421717  NM_001012878.1  NP_001012896.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA76
    --
    64(a)
    1 ↔ 1
    1(180399509-180442908)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.198162 Transcribed sequence with weak similarity to protein more 76.35(n)    57051357 
    fruit fly
    (Drosophila melanogaster)
    Insecta mtd6
    mustard
    18(a)
    1 → many
    3R(1095838-1176165)
    worm
    (Caenorhabditis elegans)
    Secernentea F52E1.136
    Protein F52E1.13, isoform c
    23(a)
    1 → many
    V(8415668-8444752)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G055906
    AT4G398706
    TLD-domain containing nucleolar protein
    24(a)
    20(a)
    many ↔ many
    many ↔ many
    2(2067097-2069206)
    4(18501877-18504466)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    TLD family protein, putative, expressed
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    2(31701789-31705122)
    6(6242661-6246720)


    ENSEMBL Gene Tree for NCOA7 (if available)
    TreeFam Gene Tree for NCOA7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCOA7 gene
    OXR12  C20orf1182  KIAA16092  
    5 SIMAP similar genes for NCOA7 using alignment to 12 protein entries:     NCOA7_HUMAN (see all proteins):
    Nbla00052    DKFZp451P0217    DKFZp761B2210    C20orf118    OXR1

    NCOA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2324 NCBI SNPs in NCOA7 are shown (see all 2324    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872944101,2
    --126100328(+) ATAGCA/CGGGCC 2 -- us2k10--------
    rs1157486251,2
    --126100521(+) CAAAGG/ATTAGG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs17393861,2
    C,F,H,--126100556(+) AAAAAC/ACCTTA 2 -- us2k19Minor allele frequency- A:0.14NS EA WA CSA 646
    rs1918680251,2
    --126100589(+) CTTTTC/TTTGAC 2 -- us2k10--------
    rs1497175291,2
    --126100625(+) AGGAAC/TTCCCA 2 -- us2k10--------
    rs1839505071,2
    --126100782(+) GTTAGA/CCAAAA 2 -- us2k10--------
    rs1894039311,2
    --126100908(+) AATAAA/TCTCCA 2 -- us2k10--------
    rs775230441,2
    F,--126100927(+) AATCTT/CAATGT 2 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1927166521,2
    --126101026(+) AATCAA/GGGTTA 2 -- us2k10--------
    rs1445673191,2
    --126101103(+) TTAGAA/GTCACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCOA7 (126102307 - 126252266 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for NCOA7
         9 CNVs: 93998 64653 94000 81577 99700 22541 38103 36452 93999

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA7
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NCOA7 for disorders           About GeneDecksing

    OMIM gene information: 609752    OMIM disorders: --

    5 diseases for NCOA7:    About MalaCards
    neuroblastoma    schizophrenia    thyroiditis    malaria
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: NCOA7 (2 documents)

    Export disorders for NCOA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCOA7 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with NCOA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ERAP140, a conserved tissue-specific nuclear receptor coactivator. (PubMed id 11971969)1, 2, 3 Shao W.... Brown M. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. (PubMed id 10395741)1, 2 Nguyen T.A.... Safe S. (1999)
    7. No association between the Nuclear Receptor Coactivator 7 gene and schizophrenia in the Chinese Han population. (PubMed id 17079118)1, 9 Liu Y....He L. (2007)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. A multistage association study identifies a breast ca ncer genetic locus at NCOA7. (PubMed id 21610108)1 Higginbotham K.S....Smith J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135112 HGNC: 21081 AceView: NCOA7 Ensembl:ENSG00000111912 euGenes: HUgn135112
    ECgene: NCOA7 H-InvDB: NCOA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCOA7 gene:
    Search GeneIP for patents involving NCOA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NCOA7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOA7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA7  
     OriGene Protein Over-expression Lysate for NCOA7   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for NCOA7  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NCOA7   OriGene Custom Protein Services for NCOA7  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCOA7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOA7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA7
     GenScript Custom Purified and Recombinant Proteins Services for NCOA7 GenScript cDNA clones with any tag delivered in your preferred vector for NCOA7
     GenScript Custom Assay Services for NCOA7 GenScript Custom Superior Antibodies Services for NCOA7
     GenScript Custom overexpressing Cell Line Services for NCOA7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NCOA7 promoter
     Search Chromatin IP Primers for NCOA7
     RT2 qPCR Primer Assay in human, mouse, rat NCOA7
     GNC Network for NCOA7
     SABiosciences PCR Arrays including human, mouse, rat NCOA7
     Search Tocris compounds for NCOA7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NCOA7 antibodies
     Search for Antibodies for NCOA7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NCOA7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NCOA7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NCOA7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA7
     SwitchGear 3'UTR luciferase reporter plasmids for NCOA7
     SwitchGear Promoter luciferase reporter plasmids for NCOA7
     ThermoFisher Antibody for NCOA7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA7
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NCOA7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4