Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCOA7 Gene

Aliases for NCOA7 Gene

  • Nuclear Receptor Coactivator 7 2 3 5
  • 140 KDa Estrogen Receptor-Associated Protein 3 4
  • TBC/LysM-Associated Domain Containing 4 2 3
  • Estrogen Nuclear Receptor Coactivator 1 3 4
  • ERAP140 3 4
  • ESNA1 3 4
  • Estrogen Receptor Associated Protein 140 KDa 3
  • Putative Protein Product Of Nbla00052 3
  • Putative Protein Product Of Nbla10993 3
  • DJ187J11.3 3
  • Nbla00052 3
  • Nbla10993 3
  • NCOA7-AS 3
  • TLDC4 3

External Ids for NCOA7 Gene

Previous GeneCards Identifiers for NCOA7 Gene

  • GC06P126037
  • GC06P126082
  • GC06P126144
  • GC06P126102
  • GC06P123687

Summaries for NCOA7 Gene

GeneCards Summary for NCOA7 Gene

NCOA7 (Nuclear Receptor Coactivator 7) is a Protein Coding gene. Diseases associated with NCOA7 include Brugada Syndrome. Among its related pathways are Aryl Hydrocarbon Receptor and AHR Pathway. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity and nuclear hormone receptor binding. An important paralog of this gene is OXR1.

UniProtKB/Swiss-Prot for NCOA7 Gene

  • Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Gene Wiki entry for NCOA7 Gene

Additional gene information for NCOA7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA7 Gene

Genomics for NCOA7 Gene

GeneHancer (GH) Regulatory Elements for NCOA7 Gene

Promoters and enhancers for NCOA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I125917 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.8 +138.8 138794 4.3 HDGF FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 NCOA7 HINT3 NCOA7-AS1 PIR57980 PIR42096
GH06I125788 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.8 +10.8 10766 6.3 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 ZNF2 ZNF766 ZNF213 NCOA7 HEY2 RNF217 HINT3 NCOA7-AS1 LOC105377986 TRMT11
GH06I125779 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 367 3.4 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NCOA7 TRE-CTC1-7 HEY2 CENPW TRMT11 RNF217-AS1 RNF217 NCOA7-AS1
GH06I125940 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +163.8 163785 9.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 RNF217 CENPW NCOA7-AS1 HEY2 LOC105377986 NCOA7 TRMT11 PIR42096 HINT3
GH06I125955 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.7 +175.9 175930 3.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 HINT3 CENPW TRMT11 NCOA7 RNA5SP216
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCOA7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCOA7 gene promoter:

Genomic Locations for NCOA7 Gene

Genomic Locations for NCOA7 Gene
chr6:125,781,131-125,932,030
(GRCh38/hg38)
Size:
150,900 bases
Orientation:
Plus strand
chr6:126,102,307-126,253,176
(GRCh37/hg19)

Genomic View for NCOA7 Gene

Genes around NCOA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA7 Gene

Proteins for NCOA7 Gene

  • Protein details for NCOA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI08-NCOA7_HUMAN
    Recommended name:
    Nuclear receptor coactivator 7
    Protein Accession:
    Q8NI08
    Secondary Accessions:
    • B2RNS2
    • B7Z2C4
    • B9EH71
    • G8JL91
    • Q3LID6
    • Q4G0V1
    • Q5TF95
    • Q6IPQ4
    • Q6NE83
    • Q86T89
    • Q8N1W4

    Protein attributes for NCOA7 Gene

    Size:
    942 amino acids
    Molecular mass:
    106162 Da
    Quaternary structure:
    • Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.
    SequenceCaution:
    • Sequence=CAD89948.1; Type=Frameshift; Positions=782; Evidence={ECO:0000305};

    Alternative splice isoforms for NCOA7 Gene

neXtProt entry for NCOA7 Gene

Post-translational modifications for NCOA7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NCOA7 Gene

Domains & Families for NCOA7 Gene

Gene Families for NCOA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCOA7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NI08

UniProtKB/Swiss-Prot:

NCOA7_HUMAN :
  • Belongs to the OXR1 family.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with NCOA7: view

Function for NCOA7 Gene

Molecular function for NCOA7 Gene

UniProtKB/Swiss-Prot Function:
Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Phenotypes From GWAS Catalog for NCOA7 Gene

Gene Ontology (GO) - Molecular Function for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10395741
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 11971969
GO:0035257 nuclear hormone receptor binding IDA 11971969
genes like me logo Genes that share ontologies with NCOA7: view
genes like me logo Genes that share phenotypes with NCOA7: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCOA7 Gene

Localization for NCOA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA7 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NCOA7: view

Pathways & Interactions for NCOA7 Gene

genes like me logo Genes that share pathways with NCOA7: view

Pathways by source for NCOA7 Gene

1 BioSystems pathway for NCOA7 Gene
1 Qiagen pathway for NCOA7 Gene

Gene Ontology (GO) - Biological Process for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 11971969
GO:1900408 negative regulation of cellular response to oxidative stress IEA --
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation IEA --
genes like me logo Genes that share ontologies with NCOA7: view

No data available for SIGNOR curated interactions for NCOA7 Gene

Drugs & Compounds for NCOA7 Gene

No Compound Related Data Available

Transcripts for NCOA7 Gene

Unigene Clusters for NCOA7 Gene

Nuclear receptor coactivator 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - -
SP9:

ExUns: 18b ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NCOA7 Gene

GeneLoc Exon Structure for
NCOA7
ECgene alternative splicing isoforms for
NCOA7

Expression for NCOA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA7 Gene

This gene is overexpressed in Brain (14.2) and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOA7 Gene



Protein tissue co-expression partners for NCOA7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCOA7 Gene:

NCOA7

SOURCE GeneReport for Unigene cluster for NCOA7 Gene:

Hs.171426

mRNA Expression by UniProt/SwissProt for NCOA7 Gene:

Q8NI08-NCOA7_HUMAN
Tissue specificity: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.

Evidence on tissue expression from TISSUES for NCOA7 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Liver(4.3)
  • Lung(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NCOA7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA7 Gene

Orthologs for NCOA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA7 34 33
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA7 33 34
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia NCOA7 33 34
  • 89.05 (n)
-- 34
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ncoa7 33 16 34
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Ncoa7 33
  • 83.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA7 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA7 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA7 33 34
  • 70.85 (n)
lizard
(Anolis carolinensis)
Reptilia NCOA7 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487448 33
  • 67.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC569262 33
  • 69.01 (n)
NCOA7 (2 of 2) 34
  • 53 (a)
OneToMany
NCOA7 (1 of 2) 34
  • 45 (a)
OneToMany
Dr.19816 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1872 33
Species where no ortholog for NCOA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA7 Gene

ENSEMBL:
Gene Tree for NCOA7 (if available)
TreeFam:
Gene Tree for NCOA7 (if available)

Paralogs for NCOA7 Gene

Paralogs for NCOA7 Gene

genes like me logo Genes that share paralogs with NCOA7: view

Variants for NCOA7 Gene

Sequence variations from dbSNP and Humsavar for NCOA7 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000041821 -- 125,881,652(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000044764 -- 125,914,821(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000067922 -- 125,875,569(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000089583 -- 125,911,362(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000093232 -- 125,843,511(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA7 Gene

Variant ID Type Subtype PubMed ID
dgv1064n67 CNV loss 20364138
dgv10925n54 CNV loss 21841781
dgv10926n54 CNV loss 21841781
dgv10927n54 CNV loss 21841781
dgv10928n54 CNV loss 21841781
dgv10929n54 CNV loss 21841781
dgv1150e199 CNV deletion 23128226
dgv3384n106 CNV deletion 24896259
dgv403e215 CNV deletion 23714750
esv23026 CNV gain+loss 19812545
esv2421628 CNV deletion 20811451
esv2425031 CNV deletion 19546169
esv2599261 CNV loss 19546169
esv2670095 CNV deletion 23128226
esv2677863 CNV deletion 23128226
esv2732680 CNV deletion 23290073
esv3610697 CNV loss 21293372
esv3610698 CNV loss 21293372
esv3610699 CNV loss 21293372
esv3610700 CNV gain 21293372
nsv1019490 CNV loss 25217958
nsv1074959 CNV deletion 25765185
nsv1161451 OTHER complex 26073780
nsv436509 CNV deletion 17901297
nsv441685 CNV loss 18776908
nsv499628 CNV loss 21111241
nsv514387 CNV loss 21397061
nsv5467 CNV deletion 18451855
nsv604607 CNV loss 21841781
nsv604616 CNV loss 21841781
nsv820882 CNV deletion 20802225
nsv830796 CNV loss 17160897
nsv950505 CNV duplication 24416366

Variation tolerance for NCOA7 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCOA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA7 Gene

Disorders for NCOA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCOA7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • bangungut
- elite association - COSMIC cancer census association via MalaCards
Search NCOA7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCOA7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NCOA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA7 Gene

Publications for NCOA7 Gene

  1. No association between the Nuclear Receptor Coactivator 7 gene and schizophrenia in the Chinese Han population. (PMID: 17079118) Liu Y … He L (Schizophrenia research 2007) 3 22 44 58
  2. ERAP140, a conserved tissue-specific nuclear receptor coactivator. (PMID: 11971969) Shao W … Brown M (Molecular and cellular biology 2002) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M … Nakagawara A (Cancer letters 2003) 3 4 58

Products for NCOA7 Gene

Sources for NCOA7 Gene

Content
Loading form....