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Aliases for NCOA7 Gene

Aliases for NCOA7 Gene

  • Nuclear Receptor Coactivator 7 2 3
  • ERAP140 3 4 6
  • 140 KDa Estrogen Receptor-Associated Protein 3 4
  • TBC/LysM-Associated Domain Containing 4 2 3
  • Estrogen Nuclear Receptor Coactivator 1 3 4
  • ESNA1 3 4
  • Estrogen Receptor Associated Protein 140 KDa 3
  • Putative Protein Product Of Nbla00052 3
  • Putative Protein Product Of Nbla10993 3
  • DJ187J11.3 3
  • Nbla00052 3
  • Nbla10993 3
  • NCOA7-AS 3
  • TLDC4 3

External Ids for NCOA7 Gene

Previous GeneCards Identifiers for NCOA7 Gene

  • GC06P126037
  • GC06P126082
  • GC06P126144
  • GC06P126102
  • GC06P123687

Summaries for NCOA7 Gene

GeneCards Summary for NCOA7 Gene

NCOA7 (Nuclear Receptor Coactivator 7) is a Protein Coding gene. Among its related pathways are AHR Pathway (Qiagen). GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity and nuclear hormone receptor binding. An important paralog of this gene is TLDC2.

UniProtKB/Swiss-Prot for NCOA7 Gene

  • Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Gene Wiki entry for NCOA7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA7 Gene

Genomics for NCOA7 Gene

Regulatory Elements for NCOA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCOA7 Gene

Start:
125,781,121 bp from pter
End:
125,932,030 bp from pter
Size:
150,910 bases
Orientation:
Plus strand

Genomic View for NCOA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA7 Gene

Proteins for NCOA7 Gene

  • Protein details for NCOA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI08-NCOA7_HUMAN
    Recommended name:
    Nuclear receptor coactivator 7
    Protein Accession:
    Q8NI08
    Secondary Accessions:
    • B2RNS2
    • B7Z2C4
    • B9EH71
    • G8JL91
    • Q3LID6
    • Q4G0V1
    • Q5TF95
    • Q6IPQ4
    • Q6NE83
    • Q86T89
    • Q8N1W4

    Protein attributes for NCOA7 Gene

    Size:
    942 amino acids
    Molecular mass:
    106162 Da
    Quaternary structure:
    • Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.
    SequenceCaution:
    • Sequence=CAD89948.1; Type=Frameshift; Positions=782; Evidence={ECO:0000305};

    Alternative splice isoforms for NCOA7 Gene

neXtProt entry for NCOA7 Gene

Proteomics data for NCOA7 Gene at MOPED

Post-translational modifications for NCOA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCOA7 Gene

Domains for NCOA7 Gene

Protein Domains for NCOA7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NI08

UniProtKB/Swiss-Prot:

NCOA7_HUMAN :
  • Q8NI08
Domain:
  • Contains 1 TLD domain.
Family:
  • Belongs to the OXR1 family.
Similarity:
  • Contains 1 LysM repeat.
genes like me logo Genes that share domains with NCOA7: view

No data available for Gene Families for NCOA7 Gene

Function for NCOA7 Gene

Molecular function for NCOA7 Gene

UniProtKB/Swiss-Prot Function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.

Gene Ontology (GO) - Molecular Function for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10395741
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 11971969
GO:0035257 nuclear hormone receptor binding IDA 11971969
genes like me logo Genes that share ontologies with NCOA7: view

Animal Model Products

CRISPR Products

miRNA for NCOA7 Gene

miRTarBase miRNAs that target NCOA7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCOA7 Gene

Localization for NCOA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA7 Gene COMPARTMENTS Subcellular localization image for NCOA7 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NCOA7: view

Pathways for NCOA7 Gene

SuperPathways for NCOA7 Gene

Superpath Contained pathways
1 AHR Pathway (Qiagen)
genes like me logo Genes that share pathways with NCOA7: view

Pathways by source for NCOA7 Gene

1 Qiagen pathway for NCOA7 Gene

Gene Ontology (GO) - Biological Process for NCOA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 11971969
genes like me logo Genes that share ontologies with NCOA7: view

Transcripts for NCOA7 Gene

Unigene Clusters for NCOA7 Gene

Nuclear receptor coactivator 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCOA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - -
SP9:

ExUns: 18b ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NCOA7 Gene

GeneLoc Exon Structure for
NCOA7
ECgene alternative splicing isoforms for
NCOA7

Expression for NCOA7 Gene

mRNA expression in normal human tissues for NCOA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA7 Gene

SOURCE GeneReport for Unigene cluster for NCOA7 Gene Hs.171426

mRNA Expression by UniProt/SwissProt for NCOA7 Gene

Q8NI08-NCOA7_HUMAN
Tissue specificity: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.
genes like me logo Genes that share expressions with NCOA7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NCOA7 Gene

Orthologs for NCOA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA7 35
  • 99.26 (n)
  • 98.83 (a)
NCOA7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
OneToMany
NCOA7 35
  • 89.05 (n)
  • 89.13 (a)
NCOA7 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NCOA7 35
  • 89.27 (n)
  • 88.95 (a)
NCOA7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa7 35
  • 83.78 (n)
  • 83.17 (a)
Ncoa7 16
Ncoa7 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA7 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA7 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa7 35
  • 83.12 (n)
  • 82.69 (a)
chicken
(Gallus gallus)
Aves NCOA7 35
  • 70.85 (n)
  • 69 (a)
NCOA7 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA7 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487448 35
  • 67.55 (n)
  • 68.17 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1872 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19816 35
LOC569262 35
  • 69.01 (n)
  • 69.98 (a)
NCOA7 (1 of 2) 36
  • 45 (a)
OneToMany
NCOA7 (2 of 2) 36
  • 53 (a)
OneToMany
Species with no ortholog for NCOA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA7 Gene

ENSEMBL:
Gene Tree for NCOA7 (if available)
TreeFam:
Gene Tree for NCOA7 (if available)

Paralogs for NCOA7 Gene

Paralogs for NCOA7 Gene

genes like me logo Genes that share paralogs with NCOA7: view

Variants for NCOA7 Gene

Sequence variations from dbSNP and Humsavar for NCOA7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1567 - 125,928,768(+) TTTGA(G/T)TGAAA missense, reference
rs2132 -- 125,795,955(-) TTTGT(A/T)TTACT intron-variant
rs361511 -- 125,796,097(-) CTCAA(A/C/G)GAAGA intron-variant
rs361512 -- 125,796,095(-) CAAGG(A/G)AGAAA intron-variant
rs361513 -- 125,796,038(-) ATTGG(A/G)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA7 Gene

Variant ID Type Subtype PubMed ID
nsv5467 CNV Loss 18451855
esv2677863 CNV Deletion 23128226
nsv830796 CNV Loss 17160897
esv2670095 CNV Deletion 23128226
esv2425031 CNV Deletion 19546169
nsv436509 CNV Deletion 17901297
esv2599261 CNV Loss 19546169
dgv1150e199 CNV Deletion 23128226
esv2732680 CNV Deletion 23290073
nsv499628 CNV Loss 21111241
nsv820882 CNV Deletion 20802225
dgv1064n67 CNV Loss 20364138
esv23026 CNV Gain+Loss 19812545
nsv514387 CNV Loss 21397061
esv2421628 CNV Deletion 20811451
nsv441685 CNV CNV 18776908

Relevant External Links for NCOA7 Gene

HapMap Linkage Disequilibrium report
NCOA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA7 Gene

Disorders for NCOA7 Gene

Relevant External Links for NCOA7

Genetic Association Database (GAD)
NCOA7
Human Genome Epidemiology (HuGE) Navigator
NCOA7
genes like me logo Genes that share disorders with NCOA7: view

No data available for UniProtKB/Swiss-Prot for NCOA7 Gene

Publications for NCOA7 Gene

  1. No association between the Nuclear Receptor Coactivator 7 gene and schizophrenia in the Chinese Han population. (PMID: 17079118) Liu Y. … He L. (Schizophr. Res. 2007) 3 23 48
  2. ERAP140, a conserved tissue-specific nuclear receptor coactivator. (PMID: 11971969) Shao W. … Brown M. (Mol. Cell. Biol. 2002) 2 3 4
  3. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. (PMID: 10395741) Nguyen T.A. … Safe S. (Arch. Biochem. Biophys. 1999) 3 4
  4. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for NCOA7 Gene

Sources for NCOA7 Gene

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