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Aliases for NCOA6 Gene

Aliases for NCOA6 Gene

  • Nuclear Receptor Coactivator 6 2 3 5
  • Nuclear Receptor Coactivator RAP250 2 3 4
  • Peroxisome Proliferator-Activated Receptor Interacting Protein 2 3
  • Peroxisome Proliferator-Activated Receptor-Interacting Protein 3 4
  • Cancer-Amplified Transcriptional Coactivator ASC-2 3 4
  • Nuclear Receptor-Activating Protein, 250 KDa 3 4
  • Thyroid Hormone Receptor-Binding Protein 3 4
  • Amplified In Breast Cancer Protein 3 3 4
  • Activating Signal Cointegrator-2 2 3
  • Activating Signal Cointegrator 2 3 4
  • PPAR-Interacting Protein 3 4
  • NRC RAP250 3 4
  • RAP250 3 4
  • AIB3 3 4
  • PRIP 3 4
  • TRBP 3 4
  • Thyroid Hormone Receptor Binding Protein 3
  • Amplified In Breast Cancer-3 Protein 3
  • KIAA0181 4
  • ASC-2 4
  • ASC2 3
  • NRC 3

External Ids for NCOA6 Gene

Previous GeneCards Identifiers for NCOA6 Gene

  • GC20M033061
  • GC20M033971
  • GC20M034018
  • GC20M032766
  • GC20M033302
  • GC20M030081

Summaries for NCOA6 Gene

Entrez Gene Summary for NCOA6 Gene

  • The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCOA6 Gene

NCOA6 (Nuclear Receptor Coactivator 6) is a Protein Coding gene. Diseases associated with NCOA6 include hypertensive retinopathy and malignant melanoma, somatic. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include chromatin binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for NCOA6 Gene

  • Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Gene Wiki entry for NCOA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA6 Gene

Genomics for NCOA6 Gene

Regulatory Elements for NCOA6 Gene

Enhancers for NCOA6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCOA6 on UCSC Golden Path with GeneCards custom track

Promoters for NCOA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCOA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCOA6 Gene

Chromosome:
20
Start:
34,689,097 bp from pter
End:
34,825,649 bp from pter
Size:
136,553 bases
Orientation:
Minus strand

Genomic View for NCOA6 Gene

Genes around NCOA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA6 Gene

Proteins for NCOA6 Gene

  • Protein details for NCOA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14686-NCOA6_HUMAN
    Recommended name:
    Nuclear receptor coactivator 6
    Protein Accession:
    Q14686
    Secondary Accessions:
    • A6NLF1
    • B2RMN5
    • E1P5P7
    • Q9NTZ9
    • Q9UH74
    • Q9UK86

    Protein attributes for NCOA6 Gene

    Size:
    2063 amino acids
    Molecular mass:
    219145 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors.
    Miscellaneous:
    • Frequently amplified or overexpressed in colon, breast and lung cancers.
    SequenceCaution:
    • Sequence=AAF16403.1; Type=Frameshift; Positions=88; Evidence={ECO:0000305}; Sequence=BAA11498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NCOA6 Gene

Proteomics data for NCOA6 Gene at MOPED

Post-translational modifications for NCOA6 Gene

Other Protein References for NCOA6 Gene

No data available for DME Specific Peptides for NCOA6 Gene

Domains & Families for NCOA6 Gene

Protein Domains for NCOA6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14686

UniProtKB/Swiss-Prot:

NCOA6_HUMAN :
  • Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors.
Domain:
  • Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors.
genes like me logo Genes that share domains with NCOA6: view

No data available for Gene Families for NCOA6 Gene

Function for NCOA6 Gene

Molecular function for NCOA6 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Gene Ontology (GO) - Molecular Function for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0019904 protein domain specific binding IEA --
GO:0035257 nuclear hormone receptor binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0042974 retinoic acid receptor binding IEA --
genes like me logo Genes that share ontologies with NCOA6: view
genes like me logo Genes that share phenotypes with NCOA6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCOA6 Gene

Localization for NCOA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA6 Gene COMPARTMENTS Subcellular localization image for NCOA6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035097 histone methyltransferase complex IDA 17500065
genes like me logo Genes that share ontologies with NCOA6: view

Pathways & Interactions for NCOA6 Gene

genes like me logo Genes that share pathways with NCOA6: view

Gene Ontology (GO) - Biological Process for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 11443112
GO:0006367 transcription initiation from RNA polymerase II promoter ISS --
GO:0007420 brain development ISS --
GO:0030520 intracellular estrogen receptor signaling pathway NAS 11443112
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with NCOA6: view

No data available for SIGNOR curated interactions for NCOA6 Gene

Drugs & Compounds for NCOA6 Gene

(2) Drugs for NCOA6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cholecalciferol Approved Nutra Fat-soluble secosteroids 810,804

(2) Additional Compounds for NCOA6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOA6: view

Transcripts for NCOA6 Gene

Unigene Clusters for NCOA6 Gene

Nuclear receptor coactivator 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
SP1: -
SP2: - -
SP3: -
SP4: -
SP5: - - - - -
SP6:
SP7: -
SP8:
SP9:
SP10: - -
SP11:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NCOA6 Gene

GeneLoc Exon Structure for
NCOA6
ECgene alternative splicing isoforms for
NCOA6

Expression for NCOA6 Gene

mRNA expression in normal human tissues for NCOA6 Gene

Protein differential expression in normal tissues from HIPED for NCOA6 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA6 Gene



SOURCE GeneReport for Unigene cluster for NCOA6 Gene Hs.368971

mRNA Expression by UniProt/SwissProt for NCOA6 Gene

Q14686-NCOA6_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.
genes like me logo Genes that share expression patterns with NCOA6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NCOA6 Gene

Orthologs for NCOA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCOA6 35
  • 92.66 (n)
  • 93.36 (a)
NCOA6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA6 35
  • 95.31 (n)
  • 96.56 (a)
NCOA6 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCOA6 35
  • 99.42 (n)
  • 99.47 (a)
NCOA6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa6 35
  • 90.67 (n)
  • 91.69 (a)
oppossum
(Monodelphis domestica)
Mammalia NCOA6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa6 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA6 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA6 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA6 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16504 35
zebrafish
(Danio rerio)
Actinopterygii ncoa6 35
  • 52.52 (n)
  • 46.82 (a)
ncoa6 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5036 36
  • 40 (a)
OneToOne
Species with no ortholog for NCOA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA6 Gene

ENSEMBL:
Gene Tree for NCOA6 (if available)
TreeFam:
Gene Tree for NCOA6 (if available)

Paralogs for NCOA6 Gene

Pseudogenes.org Pseudogenes for NCOA6 Gene

genes like me logo Genes that share paralogs with NCOA6: view

No data available for Paralogs for NCOA6 Gene

Variants for NCOA6 Gene

Sequence variations from dbSNP and Humsavar for NCOA6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6060031 - 34,754,862(+) GTTTA(A/G)GCATT intron-variant, nc-transcript-variant, reference, missense
rs17092079 - 34,746,857(+) CCAAG(C/T)TAATT nc-transcript-variant, reference, missense
rs6060022 - 34,732,575(+) GACTA(C/T)GGCAG nc-transcript-variant, reference, missense
VAR_036551 A breast cancer sample
VAR_036552 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for NCOA6 Gene

Variant ID Type Subtype PubMed ID
nsv819225 CNV Loss 19587683
nsv3361 CNV Insertion 18451855
nsv820037 CNV Loss 19587683
esv2668087 CNV Deletion 23128226

Variation tolerance for NCOA6 Gene

Residual Variation Intolerance Score: 5.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA6 Gene

HapMap Linkage Disequilibrium report
NCOA6
Human Gene Mutation Database (HGMD)
NCOA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA6 Gene

Disorders for NCOA6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NCOA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertensive retinopathy
malignant melanoma, somatic
  • familial melanoma
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search NCOA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOA6

Genetic Association Database (GAD)
NCOA6
Human Genome Epidemiology (HuGE) Navigator
NCOA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA6
genes like me logo Genes that share disorders with NCOA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA6 Gene

Publications for NCOA6 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children. (PMID: 18462265) Burghardt H. … Zorzano A. (Clin. Endocrinol. (Oxf) 2008) 3 23
  3. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. (PMID: 18552123) Surapureddi S. … Goldstein J.A. (Mol. Pharmacol. 2008) 3 23
  4. Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. (PMID: 14645241) Goo Y.H. … Lee J.W. (J. Biol. Chem. 2004) 3 23
  5. Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid. (PMID: 14734562) Hong S. … Cheong J. (J. Biol. Chem. 2004) 3 23

Products for NCOA6 Gene

Sources for NCOA6 Gene

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