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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA6 Gene

protein-coding   GIFtS: 57
GCID: GC20M033302

nuclear receptor coactivator 6
 Explore 15 diseases affiliated with
NCOA6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NCOA6    

Aliases
for NCOA6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Coactivator 61 2     Nuclear Receptor Coactivator RAP2502 3
PRIP1 2 3 5     Nuclear Receptor-Activating Protein, 250 KDa2 3
RAP2501 2 3 5     Peroxisome Proliferator-Activated Receptor-Interacting Protein2 3
AIB31 2 3     Thyroid Hormone Receptor-Binding Protein2 3
TRBP1 2 3     NRC RAP2502 3
ASC21 2 5     PPAR-Interacting Protein2 3
NRC1 2 5     Activating Signal Cointegrator-22
KIAA01811 3     Amplified In Breast Cancer-3 Protein2
Activating Signal Cointegrator 22 3     Peroxisome Proliferator-Activated Receptor Interacting Protein2
Amplified In Breast Cancer Protein 32 3     Thyroid Hormone Receptor Binding Protein2
Cancer-Amplified Transcriptional Coactivator ASC-22 3     ASC-23

External Ids:    HGNC: 159361   Entrez Gene: 230542   Ensembl: ENSG000001986467   OMIM: 6052995   UniProtKB: Q146863   

Export aliases for NCOA6 gene to outside databases

Previous GC identifers: GC20M033061 GC20M033971 GC20M034018 GC20M032766 GC20M030081


Summaries
for NCOA6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NCOA6:
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to
enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent
coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided by
RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in
the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid
hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just
a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate
expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins

Gene Wiki entry for NCOA6


Genomic Views
for NCOA6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA6 gene promoter:
         SRF   p53   Sp1   AP-1   SRF (504 AA)   ATF-2   HSF1short   STAT3   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCOA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCOA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11

NCOA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M033302:  view genomic region     (about GC identifiers)

Start:
 33,302,578 bp from pter      End:
 33,413,452 bp from pter
Size:
 110,875 bases      Orientation:
 minus strand

Proteins
for NCOA6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 6  
Size: 2063 amino acids; 219145 Da
Subunit: Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription
factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the
histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of
the MLL2/3 complex (also named ASCOM complex), at least composed of MLL2/ALR or MLL3, ASH2L, RBBP5, WDR5, NCOA6,
DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335
Subcellular location: Nucleus
Miscellaneous: Frequently amplified or overexpressed in colon, breast and lung cancers
Sequence caution: Sequence=AAF16403.1; Type=Frameshift; Positions=88; Sequence=BAA11498.2; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: A6NLF1 B2RMN5 E1P5P7 Q9NTZ9 Q9UH74 Q9UK86

Explore the universe of human proteins at neXtProt for NCOA6: NX_Q14686

Post-translational modifications:

  • Phosphorylated by PRKDC1
  • Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14686

    • NCOA6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229468.1  NP_054790.2  

    ENSEMBL proteins: 
     ENSP00000363929   ENSP00000351894  
    Reactome Protein details: Q14686
    Human Recombinant Protein Products: 
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    Uscn Proteins for NCOA6

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus NAS10567404
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex TAS11443112
    GO:0005730NOT nucleolus IDA--


    NCOA6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NCOA6

    Protein Domains /
    Families
    for NCOA6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NCOA6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026638 NCOA6

    Graphical View of Domain Structure for InterPro Entry Q14686

    ProtoNet protein and cluster: Q14686

    UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
    Domain: Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear
    receptors, while adjacent Ser-884 displays selectivity for nuclear receptors


    Function
    for NCOA6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in
    the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid
    hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just
    a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate
    expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins

    miRNA
    Products:            		miRTarBase miRNAs that target NCOA6:
    hsa-mir-224 (MIRT003235)

    OriGene 3'-UTR Clone: NCOA6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA6
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA6 (see all 19):
    hsa-miR-10b hsa-let-7a-2* hsa-miR-374a hsa-miR-944 hsa-miR-486-5p hsa-miR-7-1* hsa-let-7g* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmid: NCOA6 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: NCOA6
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding ISS--
    GO:0003713transcription coactivator activity IDA11443112
    GO:0005515protein binding IPI17178841
    GO:0016922ligand-dependent nuclear receptor binding ----
    GO:0019899enzyme binding IPI12039952


    NCOA6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NCOA6:
     Decreased Hepatitis C virus re  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for NCOA6: Ncoa6tm1.1Jkr Ncoa6tm1Pera Ncoa6tm3.1Jxu Ncoa6tm1Hhs
         15/18 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ncoa6) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    NCOA6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NCOA6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NCOA6 
        Coregulation of Androgen receptor activity

    4        Reactome Pathways for NCOA6
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins



    NCOA6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/182 Interacting proteins for NCOA6 (Q146861, 2, 3 ENSP000003518944) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927931, 3, ENSP000002623674EBI-78670,EBI-81215 I2D: score=4 STRING: ENSP00000262367
    SMAD2Q157962, 3, ENSP000002621604MINT-61591 I2D: score=3 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-61721 I2D: score=3 STRING: ENSP00000332973
    ARP102751, 3, ENSP000003638224EBI-78670,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    MLL3Q8NEZ41, 3, ENSP000002621894EBI-78670,EBI-1042997 I2D: score=1 STRING: ENSP00000262189
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS11443112
    GO:0006281DNA repair NAS11443112
    GO:0006310DNA recombination NAS11443112
    GO:0006352DNA-dependent transcription, initiation IDA10567404
    GO:0006367transcription initiation from RNA polymerase II promoter ISS--


    NCOA6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCOA6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCOA6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NCOA6

    1 HMDB Compound for NCOA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Vitamin D3(+)-Vitamin D3 (see all 32)67-97-0--
    3 Novoseek chemical compound relationships for NCOA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 33.4 3 10567404 (1), 15161927 (1), 11773444 (1)
    retinoic acid 28.3 6 14734562 (3), 10567404 (2), 11302752 (1)
    steroid 0 1 12554768 (1)

    Search CenterWatch for drugs/clinical trials and news about NCOA6 

    Transcripts
    for NCOA6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCOA6 gene (2 alternative transcripts): 
    NM_001242539.1  NM_014071.3  

    Unigene Cluster for NCOA6:

    Nuclear receptor coactivator 6
    Hs.368971  [show with all ESTs]
    Unigene Representative Sequence: AF208227
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374796(uc002xav.3) ENST00000359003(uc021wce.1 uc021wcf.1 uc010gew.1 uc002xaw.3 uc021wcd.1)
    ENST00000471897

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA6
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    hsa-miR-10b hsa-let-7a-2* hsa-miR-374a hsa-miR-944 hsa-miR-486-5p hsa-miR-7-1* hsa-let-7g* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmid: NCOA6 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF128458.1 AF171667.1 AF177388.1 AF208227.1 AF245115.1 AK027040.1 BC047886.1 BC069829.1 
    BC114613.1 BC136272.1 D80003.2 JF707637.1 JF707638.1 JF707639.1 L37706.1 

    9 DOTS entries:

    DT.97772152  DT.95224937  DT.95224940  DT.120800592  DT.120800553  DT.120800586  DT.95224921  DT.120800611 
    DT.95330625 

    24/225 AceView cDNA sequences (see all 225):

    BQ001127 AI269699 AU139672 BQ427729 D80003 CA748669 AA536098 AI423600 
    BP356083 NM_014071 BE047296 AA416993 BM771023 AA864524 BC047886 AA931211 
    W80976 AU132349 BQ948068 BM554415 CB154899 AK027040 AI498955 AA515088 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA6 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                                                                      -                     
    SP2:        -                             -                                                                                                                     
    SP3:                                      -                                                                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                        -     -     -     -           -                     

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NCOA6

    Expression
    for NCOA6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGCATAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NCOA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA6

    SOURCE GeneReport for Unigene cluster: Hs.368971

    UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
    Tissue specificity: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus
    and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              PPAR Targets in human mouse rat
              Hematopoiesis in human mouse rat

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    Orthologs
    for NCOA6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NCOA6 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ncoa61 , 5 nuclear receptor coactivator 61, 5 90.92(n)1
    91.8(a)1    		   2 (77.26 cM)5
    564061  NM_019825.31  NP_062799.21 
     1553906655 
    chicken
    (Gallus gallus)    		 Aves NCOA66
    		 Uncharacterized protein
    		 75(a)
    		 1 ↔ 1
    		 20(490431-522628)
    lizard
    (Anolis carolinensis)    		 Reptilia NCOA66
    		 --
    		 70(a)
    		 1 ↔ 1
    		 4(138424793-138458123)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.165042 Transcribed sequence with weak similarity to protein more 73.75(n)    AL846028.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii ncoa61 nuclear receptor coactivator 6 52.87(n)
    46.84(a)    		   100144559  XM_001918962.3  XP_001918997.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea nos-36
    		 NanOS related family member (nos-3)
    		 17(a)
    		 1 ↔ 1
    		 II(9746659-9749913)


    ENSEMBL Gene Tree for NCOA6 (if available)
    TreeFam Gene Tree for NCOA6 (if available) 

    Paralogs
    for NCOA6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCOA6 gene
    BCL92  BCL9L2  

    NCOA6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NCOA6
    PGOHUM00000240997


    Genomic Variants
    for NCOA6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1767 NCBI SNPs in NCOA6 are shown (see all 1767)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1508672771,2
    		--33302134(+) ATGCCC/TGGCCC 2 -- ds50010--------
    rs72660911,2
    		C,F,--33302194(+) ACCTCC/GTGCAA 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1393606041,2
    		--33302250(+) ATGGAA/GGAGCA 2 -- ds50010--------
    rs792499681,2
    		C,--33302282(+) GTGCCA/CTCTCA 2 -- ds50010--------
    rs1807429821,2
    		--33302482(+) CAGGCA/GGGCAT 2 -- ds50010--------
    rs1477541141,2
    		--33302521(+) TTCCAC/TCCACA 2 -- ds50010--------
    rs1855320141,2
    		--33302644(+) CACATC/TGTACA 2 -- ut310--------
    rs797297551,2
    		C,--33302687(+) TTCTAA/CAACAA 2 -- ut310--------
    rs1131377381,2
    		F--33302778(+) TCACAG/CACAGT 2 -- ut312Minor allele frequency- C:0.40CSA 5
    rs736220221,2
    		C,F,--33302801(+) CAATA-/CATCATTA 2 -- ut312Minor allele frequency- CAT:0.50CSA 4

    HapMap Linkage Disequilibrium report for NCOA6 (33302578 - 33413452 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NCOA6
         2 CNVs: 59024 59023

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    Disorders / Diseases
    for NCOA6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NCOA6 for disorders           About GeneDecksing

    OMIM gene information: 605299    OMIM disorders: --

    15 diseases for NCOA6:    About MalaCards
    thyroiditis    breast cancer    human immunodeficiency virus infectious disease    aids dementia complex
    premature ovarian failure    dementia    cholestasis    hepatitis b
    hematopoiesis    retinoblastoma    immunodeficiency    lung cancer
    hepatitis    cholesterol    prostatitis

    2 Novoseek disease relationships for NCOA6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.799 6 10567404 (2), 11158331 (1), 15466215 (1), 14638867 (1)
    tumors 0 3 15466215 (2), 14638867 (1)

    Human Genome Epidemiology (HuGE) Navigator: NCOA6 (6 documents)

    Export disorders for NCOA6 gene to outside databases

    Publications
    for NCOA6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCOA6 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with NCOA6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (1996)
    2. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. (PubMed id 11773444)1, 2, 9 Ko L....Chin W.W. (2002)
    3. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PubMed id 11443112)1, 2, 9 Iwasaki T.... Ko L. (2001)
    4. A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)1, 2, 9 Lee S.-K.... Lee J.W. (1999)
    5. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. (PubMed id 11517327)1, 2, 9 Zhu Y.-J.... Reddy J.K. (2001)
    6. Cloning and characterization of RAP250, a nuclear receptor coactivator. (PubMed id 10681503)1, 2, 9 Caira F.... Gustafsson J.-A. (2000)
    7. PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex. (PubMed id 17500065)1, 2 Cho Y.W.... Ge K. (2007)
    8. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. (PubMed id 17021013)1, 2 Lee S....Lee J.W. (2006)
    9. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. (PubMed id 12482968)1, 2 Goo Y.-H....Lee J.W. (2003)
    10. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PubMed id 12215545)1, 2 Mahajan M.A.... Samuels H.H. (2002)

    External Searches for NCOA6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing NCOA6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23054 HGNC: 15936 AceView: NCOA6 Ensembl:ENSG00000198646 euGenes: HUgn23054
    ECgene: NCOA6 H-InvDB: NCOA6

    Other Databases showing NCOA6 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0181

    Specialized Databases showing NCOA6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NCOA6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCOA6 gene:
    Search GeneIP for patents involving NCOA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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