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NCOA6 Gene

protein-coding   GIFtS: 60
GCID: GC20M033302

Nuclear Receptor Coactivator 6

  See NCOA6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Coactivator 61 2     Thyroid Hormone Receptor-Binding Protein2 3
Nuclear Receptor Coactivator RAP2501 2 3     AIB32 3
PRIP2 3 5     TRBP2 3
RAP2502 3 5     NRC RAP2502 3
Activating Signal Cointegrator-21 2     PPAR-Interacting Protein2 3
Peroxisome Proliferator-Activated Receptor Interacting Protein1 2     ASC22 5
Activating Signal Cointegrator 22 3     NRC2 5
Amplified In Breast Cancer Protein 32 3     Amplified In Breast Cancer-3 Protein2
Cancer-Amplified Transcriptional Coactivator ASC-22 3     Thyroid Hormone Receptor Binding Protein2
Nuclear Receptor-Activating Protein, 250 KDa2 3     ASC-23
Peroxisome Proliferator-Activated Receptor-Interacting Protein2 3     KIAA01813

External Ids:    HGNC: 159361   Entrez Gene: 230542   Ensembl: ENSG000001986467   OMIM: 6052995   UniProtKB: Q146863   

Export aliases for NCOA6 gene to outside databases

Previous GC identifers: GC20M033061 GC20M033971 GC20M034018 GC20M032766 GC20M030081


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCOA6 Gene:
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors
to enhance their transcriptional activator functions. This protein has been shown to be involved in the
hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone,
and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described
for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for NCOA6 Gene:
NCOA6 (nuclear receptor coactivator 6) is a protein-coding gene. Diseases associated with NCOA6 include breast cancer. GO annotations related to this gene include transcription coactivator activity and chromatin binding.

UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner.
Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs
and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general
coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the
NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone
acetyltransferase proteins

Gene Wiki entry for NCOA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCOA6 gene promoter:
         SRF   p53   Sp1   AP-1   SRF (504 AA)   ATF-2   HSF1short   STAT3   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCOA6 promoter sequence
   Search Chromatin IP Primers for NCOA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCOA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11

NCOA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M033302:  view genomic region     (about GC identifiers)

Start:
33,284,722 bp from pter      End:
33,413,452 bp from pter
Size:
128,731 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 6  
Size: 2063 amino acids; 219145 Da
Subunit: Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal
transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1,
CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and
PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or
KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts
with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors
Miscellaneous: Frequently amplified or overexpressed in colon, breast and lung cancers
Sequence caution: Sequence=AAF16403.1; Type=Frameshift; Positions=88; Sequence=BAA11498.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NLF1 B2RMN5 E1P5P7 Q9NTZ9 Q9UH74 Q9UK86

Explore the universe of human proteins at neXtProt for NCOA6: NX_Q14686

Explore proteomics data for NCOA6 at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKDC1
  • Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NCOA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229468.1  NP_054790.2  

    ENSEMBL proteins: 
     ENSP00000363929   ENSP00000351894  
    Reactome Protein details: Q14686

    NCOA6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for NCOA6
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    Novus Biologicals NCOA6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOA6

     
    Search eBioscience for Proteins for NCOA6 

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NCOA6
    Cloud-Clone Corp. Antibodies for NCOA6
    Search ThermoFisher Antibodies for NCOA6
    LSBio Antibodies in human, mouse, rat for NCOA6

    NCOA6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NCOA6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCOA6
    Cloud-Clone Corp. CLIAs for NCOA6
    Search eBioscience for ELISAs for NCOA6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026638 NCOA6

    Graphical View of Domain Structure for InterPro Entry Q14686

    ProtoNet protein and cluster: Q14686

    UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
    Domain: Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with
    nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors


    Find genes that share domains with NCOA6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA6_HUMAN, Q14686
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner.
    Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs
    and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general
    coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the
    NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone
    acetyltransferase proteins

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding ISS--
    GO:0003713transcription coactivator activity IDA10567404
    GO:0005515protein binding IPI10866662
    GO:0019899enzyme binding IPI12039952
    GO:0030331estrogen receptor binding TAS11443112
         
    Find genes that share ontologies with NCOA6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NCOA6:
     Decreased Hepatitis C virus re  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ncoa6) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with NCOA6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NCOA6: Ncoa6tm1.1Jkr Ncoa6tm1Pera Ncoa6tm3.1Jxu Ncoa6tm1Hhs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCOA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCOA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCOA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCOA6

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCOA6:
    hsa-mir-224-5p (MIRT003235), hsa-mir-30b-5p (MIRT023418), hsa-mir-18a-5p (MIRT031325), hsa-mir-361-5p (MIRT044079), hsa-mir-760 (MIRT036743), hsa-mir-33a-5p (MIRT028192)

    Block miRNA regulation of human, mouse, rat NCOA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCOA6 (see all 19):
    hsa-miR-10b hsa-let-7a-2* hsa-miR-374a hsa-miR-944 hsa-miR-486-5p hsa-miR-7-1* hsa-let-7g* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidNCOA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NCOA6
    Predesigned siRNA for gene silencing in human, mouse, rat NCOA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCOA6

    Clone
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    OriGene clones in human, mouse for NCOA6 (see all 5)
    OriGene ORF clones in mouse, rat for NCOA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCOA6 (NM_014071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NCOA6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCOA6_HUMAN, Q14686: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10567404
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex TAS11443112
    GO:0005730NOT nucleolus IDA--
    GO:0035097histone methyltransferase complex IDA17500065

    Find genes that share ontologies with NCOA6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCOA6 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    RORA Activates Circadian Expression0.88
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    4Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with NCOA6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NCOA6
        Coregulation of Androgen receptor activity

    Selected Reactome Pathways for NCOA6 (see all 10)
        Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Transcriptional activation of mitochondrial biogenesis
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              PPAR Targets in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCOA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCOA6 (Q146861, 2, 3 ENSP000003518944) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927931, 3, ENSP000002623674EBI-78670,EBI-81215 I2D: score=4 STRING: ENSP00000262367
    SMAD2Q157962, 3, ENSP000002621604MINT-61591 I2D: score=3 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-61721 I2D: score=3 STRING: ENSP00000332973
    ARP102751, 3, ENSP000003638224EBI-78670,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    KMT2CQ8NEZ41, 3, ENSP000002621894EBI-78670,EBI-1042997 I2D: score=1 STRING: ENSP00000262189
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication NAS11443112
    GO:0006281DNA repair NAS11443112
    GO:0006310DNA recombination NAS11443112
    GO:0006352DNA-templated transcription, initiation IDA10567404
    GO:0006367transcription initiation from RNA polymerase II promoter ISS--

    Find genes that share ontologies with NCOA6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCOA6

    1 HMDB Compound for NCOA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Vitamin D3(+)-Vitamin D3 (see all 32)67-97-0--

    3 Novoseek inferred chemical compound relationships for NCOA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 33.4 3 10567404 (1), 15161927 (1), 11773444 (1)
    retinoic acid 28.3 6 14734562 (3), 10567404 (2), 11302752 (1)
    steroid 0 1 12554768 (1)



    Find genes that share compounds with NCOA6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCOA6 gene (2 alternative transcripts): 
    NM_001242539.1  NM_014071.3  

    Unigene Cluster for NCOA6:

    Nuclear receptor coactivator 6
    Hs.368971  [show with all ESTs]
    Unigene Representative Sequence: AF208227
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434040 ENST00000593786 ENST00000374796(uc002xav.3) ENST00000359003(uc021wce.1 uc021wcf.1 uc010gew.1 uc002xaw.3 uc021wcd.1)
    ENST00000471897
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCOA6 (see all 19):
    hsa-miR-10b hsa-let-7a-2* hsa-miR-374a hsa-miR-944 hsa-miR-486-5p hsa-miR-7-1* hsa-let-7g* hsa-miR-376a*
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NCOA6 (NM_014071)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NCOA6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCOA6
      QuantiTect SYBR Green Assays in human, mouse, rat NCOA6
      QuantiFast Probe-based Assays in human, mouse, rat NCOA6

    Additional mRNA sequence: 

    AF128458.1 AF171667.1 AF177388.1 AF208227.1 AF245115.1 AK027040.1 BC047886.1 BC069829.1 
    BC114613.1 BC136272.1 D80003.2 JF707637.1 JF707638.1 JF707639.1 L37706.1 

    10 DOTS entries:

    DT.97772152  DT.95224937  DT.95224940  DT.120800592  DT.120800553  DT.120800586  DT.95224921  DT.120800611 
    DT.95330625  DT.97811930 

    Selected AceView cDNA sequences (see all 225):

    W92633 W80976 BP356083 BM799488 BM464775 BM770814 BI035798 BM554415 
    BQ427729 AI393776 BC035676 AK027040 BQ027856 AA367611 AA864524 BE047296 
    AI423600 AA416993 AA536098 AA811620 NM_014071 AF171667 BQ948068 BM771023 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCOA6 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                                                                                                                                      -                     
    SP2:        -                             -                                                                                                                     
    SP3:                                      -                                                                                                                     
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                        -     -     -     -           -                     

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NCOA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCOA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCATAGC
    NCOA6 Expression
    About this image


    NCOA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Larynx (Respiratory System)
    NCOA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCOA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368971

    UniProtKB/Swiss-Prot: NCOA6_HUMAN, Q14686
    Tissue specificity: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung,
    thymus and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              PPAR Targets in human mouse rat
              Hematopoiesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa65 nuclear receptor coactivator 6   --   2 (77.26 cM) 155390665 
    chicken
    (Gallus gallus)
    Aves NCOA66
    nuclear receptor coactivator 6
    74(a)
    1 ↔ 1
    20(500205-529457)
    lizard
    (Anolis carolinensis)
    Reptilia NCOA66
    nuclear receptor coactivator 6
    70(a)
    1 ↔ 1
    4(138424793-138460725)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.165042 Transcribed sequence with weak similarity to protein more 73.75(n)    AL846028.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ncoa61 nuclear receptor coactivator 6 52.52(n)
    46.82(a)
      100144559  XM_001918962.4  XP_001918997.4 


    ENSEMBL Gene Tree for NCOA6 (if available)
    TreeFam Gene Tree for NCOA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCOA6 gene

    Find genes that share paralogs with NCOA6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NCOA6
    PGOHUM00000240997


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCOA6 (see all 2131)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365524
    A breast cancer sample4--see VAR_0365522 S R mis40--------
    VAR_0365514
    A breast cancer sample4--see VAR_0365512 P S mis40--------
    rs1508672771,2
    --33302134(+) ATGCCC/TGGCCC 2 -- ds50010--------
    rs72660911,2
    C,F--33302194(+) ACCTCC/GTGCAA 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1393606041,2
    --33302250(+) ATGGAA/GGAGCA 2 -- ds50010--------
    rs792499681,2
    C--33302282(+) GTGCCA/CTCTCA 2 -- ds50010--------
    rs1807429821,2
    C--33302482(+) CAGGCA/GGGCAT 2 -- ds50010--------
    rs1477541141,2
    --33302521(+) TTCCAC/TCCACA 2 -- ds50010--------
    rs1855320141,2
    --33302644(+) CACATC/TGTACA 2 -- ut310--------
    rs797297551,2
    C--33302687(+) TTCTAA/CAACAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NCOA6 (33284722 - 33413452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NCOA6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668087CNV Deletion23128226
    nsv3361CNV Insertion18451855
    nsv820037CNV Loss19587683
    nsv819225CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCOA6
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605299    OMIM disorders: --

    1 disease for NCOA6:    
    About MalaCards
    breast cancer


    Find genes that share disorders with NCOA6           About GenesLikeMe

    2 Novoseek inferred disease relationships for NCOA6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.799 6 10567404 (2), 11158331 (1), 15466215 (1), 14638867 (1)
    tumors 0 3 15466215 (2), 14638867 (1)

    Genetic Association Database (GAD): NCOA6
    Human Genome Epidemiology (HuGE) Navigator: NCOA6 (6 documents)

    Export disorders for NCOA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCOA6 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with NCOA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children. (PubMed id 18462265)1, 4, 9 Burghardt H....Zorzano A. (Clin. Endocrinol. (Oxf) 2008)
    3. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. (PubMed id 11773444)1, 2, 9 Ko L....Chin W.W. (Mol. Endocrinol. 2002)
    4. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PubMed id 11443112)1, 2, 9 Iwasaki T.... Ko L. (J. Biol. Chem. 2001)
    5. A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)1, 2, 9 Lee S.-K.... Lee J.W. (J. Biol. Chem. 1999)
    6. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. (PubMed id 11517327)1, 2, 9 Zhu Y.-J.... Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    7. Cloning and characterization of RAP250, a nuclear receptor coactivator. (PubMed id 10681503)1, 2, 9 Caira F.... Gustafsson J.-A. (J. Biol. Chem. 2000)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study. (PubMed id 20721975)1, 4 Kim J.S....Park J.Y. (Mol. Carcinog. 2010)
    10. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23054 HGNC: 15936 AceView: NCOA6 Ensembl:ENSG00000198646 euGenes: HUgn23054
    ECgene: NCOA6 H-InvDB: NCOA6

    (According to HUGE)
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    HUGE: KIAA0181

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCOA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCOA6 gene:
    Search GeneIP for patents involving NCOA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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