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Aliases for NCOA5 Gene

Aliases for NCOA5 Gene

  • Nuclear Receptor Coactivator 5 2 3 5
  • Coactivator Independent Of AF-2 2 3 4
  • NCoA-5 3 4
  • CIA 3 4
  • BA465L10.6 3
  • KIAA1637 4

External Ids for NCOA5 Gene

Previous GeneCards Identifiers for NCOA5 Gene

  • GC20M044418
  • GC20M045328
  • GC20M045375
  • GC20M044123
  • GC20M044690
  • GC20M041430

Summaries for NCOA5 Gene

Entrez Gene Summary for NCOA5 Gene

  • This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCOA5 Gene

NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and chromatin binding.

UniProtKB/Swiss-Prot for NCOA5 Gene

  • Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Wiki entry for NCOA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA5 Gene

Genomics for NCOA5 Gene

Regulatory Elements for NCOA5 Gene

Enhancers for NCOA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCOA5 on UCSC Golden Path with GeneCards custom track

Promoters for NCOA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCOA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCOA5 Gene

Chromosome:
20
Start:
46,060,985 bp from pter
End:
46,089,952 bp from pter
Size:
28,968 bases
Orientation:
Minus strand

Genomic View for NCOA5 Gene

Genes around NCOA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA5 Gene

Proteins for NCOA5 Gene

  • Protein details for NCOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCD5-NCOA5_HUMAN
    Recommended name:
    Nuclear receptor coactivator 5
    Protein Accession:
    Q9HCD5
    Secondary Accessions:
    • B2RTV9
    • E1P5R0
    • Q6HA99
    • Q9H1F2
    • Q9H2T2
    • Q9H4Y9

    Protein attributes for NCOA5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65536 Da
    Quaternary structure:
    • Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.
    SequenceCaution:
    • Sequence=AAG36793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOA5 Gene

neXtProt entry for NCOA5 Gene

Proteomics data for NCOA5 Gene at MOPED

Post-translational modifications for NCOA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCOA5 Gene

Domains & Families for NCOA5 Gene

Protein Domains for NCOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCD5

UniProtKB/Swiss-Prot:

NCOA5_HUMAN :
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
Domain:
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
genes like me logo Genes that share domains with NCOA5: view

No data available for Gene Families for NCOA5 Gene

Function for NCOA5 Gene

Molecular function for NCOA5 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Ontology (GO) - Molecular Function for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NCOA5: view
genes like me logo Genes that share phenotypes with NCOA5: view

Animal Models for NCOA5 Gene

MGI Knock Outs for NCOA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA5 Gene

Localization for NCOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA5 Gene COMPARTMENTS Subcellular localization image for NCOA5 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NCOA5: view

Pathways & Interactions for NCOA5 Gene

SuperPathways for NCOA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with NCOA5: view

No data available for Pathways by source and SIGNOR curated interactions for NCOA5 Gene

Drugs & Compounds for NCOA5 Gene

(1) Drugs for NCOA5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL Experimental Pharma Target 0
genes like me logo Genes that share compounds with NCOA5: view

Transcripts for NCOA5 Gene

mRNA/cDNA for NCOA5 Gene

Unigene Clusters for NCOA5 Gene

Nuclear receptor coactivator 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NCOA5 Gene

GeneLoc Exon Structure for
NCOA5
ECgene alternative splicing isoforms for
NCOA5

Expression for NCOA5 Gene

mRNA expression in normal human tissues for NCOA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA5 Gene

This gene is overexpressed in Testis (14.8), Peripheral blood mononuclear cells (11.1), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA5 Gene



SOURCE GeneReport for Unigene cluster for NCOA5 Gene Hs.654991

mRNA Expression by UniProt/SwissProt for NCOA5 Gene

Q9HCD5-NCOA5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NCOA5: view

Protein tissue co-expression partners for NCOA5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for NCOA5 Gene

Orthologs for NCOA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NCOA5 35
  • 93.55 (n)
  • 95.34 (a)
NCOA5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa5 35
  • 89.58 (n)
  • 92.75 (a)
Ncoa5 16
Ncoa5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCOA5 35
  • 99.83 (n)
  • 99.83 (a)
NCOA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa5 35
  • 89.85 (n)
  • 92.56 (a)
cow
(Bos Taurus)
Mammalia NCOA5 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA5 36
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA5 35
  • 69.51 (n)
  • 74.25 (a)
NCOA5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA5 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75993 35
ncoa5 35
  • 62.63 (n)
  • 65.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia ncoa5-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8020 35
ncoa5 35
  • 58.33 (n)
  • 57.94 (a)
ncoa5 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9868 35
Species with no ortholog for NCOA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA5 Gene

ENSEMBL:
Gene Tree for NCOA5 (if available)
TreeFam:
Gene Tree for NCOA5 (if available)

Paralogs for NCOA5 Gene

No data available for Paralogs for NCOA5 Gene

Variants for NCOA5 Gene

Sequence variations from dbSNP and Humsavar for NCOA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11549557 - 46,063,533(-) AAGAG(A/G)GAGAG reference, missense
rs10774 -- 46,089,331(+) GGCGG(A/G)GGACA intron-variant
rs11164 -- 46,060,990(+) TTTTA(C/G)TTTTT utr-variant-3-prime
rs12942 -- 46,089,326(+) ACGGT(A/G)GCGGG intron-variant
rs15018 -- 46,061,245(+) CTGGG(A/G)AGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NCOA5 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV Loss 17160897
dgv1329e1 CNV Complex 17122850

Variation tolerance for NCOA5 Gene

Residual Variation Intolerance Score: 7.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NCOA5 Gene

Disorders for NCOA5 Gene

Relevant External Links for NCOA5

Genetic Association Database (GAD)
NCOA5
Human Genome Epidemiology (HuGE) Navigator
NCOA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA5

No disorders were found for NCOA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCOA5 Gene

Publications for NCOA5 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4 67
  2. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PMID: 11113208) Sauve F. … Giguere V. (Mol. Cell. Biol. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for NCOA5 Gene

Sources for NCOA5 Gene

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