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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA5 Gene

protein-coding   GIFtS: 52
GCID: GC20M044690

Nuclear Receptor Coactivator 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Coactivator 51 2
Coactivator Independent Of AF-21 2 3
CIA2 3
NCoA-52 3
bA465L10.62
KIAA16373

External Ids:    HGNC: 159091   Entrez Gene: 577272   Ensembl: ENSG000001241607   UniProtKB: Q9HCD53   

Export aliases for NCOA5 gene to outside databases

Previous GC identifers: GC20M044418 GC20M045328 GC20M045375 GC20M044123 GC20M041430


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCOA5 Gene:
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2.
The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its
interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate
interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been
described. However, the full length nature of one of the variants has not been determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for NCOA5 Gene: 
NCOA5 (nuclear receptor coactivator 5) is a protein-coding gene. Diseases associated with NCOA5 include psoriasis, and multiple sclerosis. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NCOA5_HUMAN, Q9HCD5
Function: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with
nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR
receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors
(ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)

Gene Wiki entry for NCOA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA5 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCOA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCOA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.12

NCOA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044690:  view genomic region     (about GC identifiers)

Start:
44,689,624 bp from pter      End:
44,718,591 bp from pter
Size:
28,968 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCOA5_HUMAN, Q9HCD5 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 5  
Size: 579 amino acids; 65536 Da
Subunit: Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and
PPP1CA
Subcellular location: Nucleus
Sequence caution: Sequence=AAG36793.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for NCOA5:
1V95 (3D)        2J7X (3D)        2J7Y (3D)    
Secondary accessions: B2RTV9 E1P5R0 Q6HA99 Q9H1F2 Q9H2T2 Q9H4Y9

Explore the universe of human proteins at neXtProt for NCOA5: NX_Q9HCD5

Explore proteomics data for NCOA5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCD5

  • NCOA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCOA5 Protein Expression
    REFSEQ proteins: NP_066018.1  
    ENSEMBL proteins: 
     ENSP00000290231   ENSP00000361365  

    Human Recombinant Protein Products for NCOA5: 
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    Cloud-Clone Corp. Proteins for NCOA5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NCOA5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004154 Anticodon-bd

    Graphical View of Domain Structure for InterPro Entry Q9HCD5

    ProtoNet protein and cluster: Q9HCD5

    UniProtKB/Swiss-Prot: NCOA5_HUMAN, Q9HCD5
    Domain: Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear
    receptors


    NCOA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA5_HUMAN, Q9HCD5
    Function: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with
    nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR
    receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors
    (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11113208
         
    NCOA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCOA5:
     Decreased DCP1a protein expres 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidNCOA5 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/13 Interacting proteins for NCOA5 (Q9HCD51, 2, 3 ENSP000002902314) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC37Q165432, 3MINT-8250922 I2D: score=2 
    TSC22D1Q157142, 3MINT-8275446 I2D: score=2 
    KHDRBS1Q076663, ENSP000003138294I2D: score=1 STRING: ENSP00000313829
    NR1D2Q149953, ENSP000003100064I2D: score=1 STRING: ENSP00000310006
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    NCOA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCOA5

    1 DrugBank Compound for NCOA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about NCOA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCOA5 gene: 
    NM_020967.2  

    Unigene Cluster for NCOA5:

    Nuclear receptor coactivator 5
    Hs.654991  [show with all ESTs]
    Unigene Representative Sequence: NM_020967
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290231(uc002xrc.3 uc002xrd.3 uc002xre.3) ENST00000372291

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA5 (see all 24):
    hsa-miR-548j hsa-miR-548i hsa-miR-765 hsa-miR-410 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-30b* hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidNCOA5 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA5

    Additional mRNA sequence: 

    AB046857.1 AF230533.1 AF470686.1 BC056872.1 BC140836.1 BC151133.1 

    12 DOTS entries:

    DT.445576  DT.95195619  DT.95352984  DT.100672035  DT.92429280  DT.92429279  DT.101986539  DT.95076961 
    DT.100689936  DT.120817260  DT.450768  DT.100841075 

    24/181 AceView cDNA sequences (see all 181):

    BM669938 AA452532 AA503858 BE745816 AI671893 AA927768 AA626651 CB241124 
    BE550548 BE671965 AI569842 AI478794 BU783985 AI656769 AB046857 AI039340 
    BQ049871 BQ012567 AA345327 AA576907 AI631149 BC056872 BM853279 CA434947 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:              -                                               -                                 
    SP2:              -                                               -           -                     
    SP3:                                                              -           -                     
    SP4:              -     -                                                                           
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for NCOA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA5 expression in normal human tissues (normalized intensities)      NCOA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCGAGAT
    NCOA5 Expression
    About this image


    NCOA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See NCOA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA5

    SOURCE GeneReport for Unigene cluster: Hs.654991

    UniProtKB/Swiss-Prot: NCOA5_HUMAN, Q9HCD5
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NCOA5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa51 , 5 nuclear receptor coactivator 51, 5 89.58(n)1
    92.75(a)1
      2 (85.32 cM)5
    2288691  NM_144892.11  NP_659141.11 
     1650003575 
    chicken
    (Gallus gallus)
    Aves NCOA51 nuclear receptor coactivator 5 69.8(n)
    73.69(a)
      419304  XM_417476.2  XP_417476.2 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA56
    nuclear receptor coactivator 5
    63(a)
    1 ↔ 1
    GL343741.1(68976-95969)
    African clawed frog
    (Xenopus laevis)
    Amphibia ncoa5-prov2 nuclear receptor coactivator 5 78.08(n)    BC044688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.80202 Transcribed sequence with weak similarity to protein more 73.79(n)    BI710705.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Neos6
    Neosin
    24(a)
    1 ↔ 1
    3L(7234728-7236239)


    ENSEMBL Gene Tree for NCOA5 (if available)
    TreeFam Gene Tree for NCOA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 SNPs in NCOA5 are shown (see all 647)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844115501,2
    --44689489(+) TTCAAA/CGAGGT 1 -- ds50010--------
    rs1866835131,2
    --44689503(+) AGGCCA/GGATCA 1 -- ds50010--------
    rs1913516121,2
    --44689515(+) ATGCTC/GAGGAC 1 -- ds50010--------
    rs111641,2
    C--44689629(+) TTTTAC/GTTTTT 1 -- ut312Minor allele frequency- G:0.25MN NA 186
    rs1386598871,2
    C--44689629(+) TTTTA-/CTTTTT 1 -- ut310--------
    rs1843068771,2
    --44689652(+) AAAAGG/TAATCA 1 -- ut310--------
    rs114150911,2
    C--44689733(+) AACAT-/AAAAAT 1 -- ut310--------
    rs1157719291,2
    C,F--44689809(+) GAAGTC/TGCTGC 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs61044471,2
    C,A--44689873(+) GAGCAC/GAAACC 1 -- ut31 ese32Minor allele frequency- G:0.29NA WA 120
    rs1886503511,2
    --44689898(+) GCTTCC/TTGGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NCOA5 (44689624 - 44718591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NCOA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833991CNV Loss17160897
    dgv1329e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NCOA5
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NCOA5:    About MalaCards
    psoriasis    multiple sclerosis


    NCOA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NCOA5
    Human Genome Epidemiology (HuGE) Navigator: NCOA5 (1 document)

    Export disorders for NCOA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCOA5 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with NCOA5)
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    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2, 3 Deloukas P....Rogers J. (2001)
    2. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PubMed id 11113208)1, 2, 3 Sauve F....Giguere V. (2001)
    3. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PubMed id 20650312)1, 4 Lewis J.P....Bowden D.W. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PubMed id 15073177)1, 2 Jiang C.... Xiao H. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. A CD40 and an NCOA5 gene polymorphism confer suscepti bility to psoriasis in a Southern European population: a case-control study. (PubMed id 21645569)1 Zervou M.I....Krueger-Krasagakis S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57727 HGNC: 15909 AceView: NCOA5 Ensembl:ENSG00000124160 euGenes: HUgn57727
    ECgene: NCOA5 H-InvDB: NCOA5

    (According to HUGE)
    About This Section
    HUGE: KIAA1637

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCOA5 gene:
    Search GeneIP for patents involving NCOA5

    GeneCards and IP:
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