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Aliases for NCOA5 Gene

Aliases for NCOA5 Gene

  • Nuclear Receptor Coactivator 5 2 3
  • Coactivator Independent Of AF-2 2 3 4
  • NCoA-5 3 4
  • CIA 3 4
  • BA465L10.6 3
  • KIAA1637 4

External Ids for NCOA5 Gene

Summaries for NCOA5 Gene

Entrez Gene Summary for NCOA5 Gene

  • This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCOA5 Gene

NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NCOA5 Gene

  • Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Wiki entry for NCOA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA5 Gene

Genomics for NCOA5 Gene

Genomic Location for NCOA5 Gene

Start:
46,060,985 bp from pter
End:
46,089,952 bp from pter
Size:
28,968 bases
Orientation:
Minus strand

Genomic View for NCOA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA5 Gene

Regulatory Elements for NCOA5 Gene

Proteins for NCOA5 Gene

  • Protein details for NCOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCD5-NCOA5_HUMAN
    Recommended name:
    Nuclear receptor coactivator 5
    Protein Accession:
    Q9HCD5
    Secondary Accessions:
    • B2RTV9
    • E1P5R0
    • Q6HA99
    • Q9H1F2
    • Q9H2T2
    • Q9H4Y9

    Protein attributes for NCOA5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65536 Da
    Quaternary structure:
    • Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.
    SequenceCaution:
    • Sequence=AAG36793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOA5 Gene

neXtProt entry for NCOA5 Gene

Proteomics data for NCOA5 Gene at MOPED

Post-translational modifications for NCOA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCOA5 Gene

Domains for NCOA5 Gene

Protein Domains for NCOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCD5

UniProtKB/Swiss-Prot:

NCOA5_HUMAN
Domain:
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors:
    • Q9HCD5
genes like me logo Genes that share domains with NCOA5: view

No data available for Gene Families for NCOA5 Gene

Function for NCOA5 Gene

Molecular function for NCOA5 Gene

UniProtKB/Swiss-Prot Function: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Ontology (GO) - Molecular Function for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 11113208
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NCOA5: view

Phenotypes for NCOA5 Gene

genes like me logo Genes that share phenotypes with NCOA5: view

miRNA for NCOA5 Gene

miRTarBase miRNAs that target NCOA5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCOA5 Gene

Localization for NCOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA5 Gene COMPARTMENTS Subcellular localization image for NCOA5 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NCOA5: view

Pathways for NCOA5 Gene

SuperPathways for NCOA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042593 glucose homeostasis IEA --
GO:0046627 negative regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NCOA5: view

No data available for Pathways by source for NCOA5 Gene

Compounds for NCOA5 Gene

(1) Drugbank Compounds for NCOA5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL
target
genes like me logo Genes that share compounds with NCOA5: view

Transcripts for NCOA5 Gene

Unigene Clusters for NCOA5 Gene

Nuclear receptor coactivator 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NCOA5 Gene

GeneLoc Exon Structure for
NCOA5
ECgene alternative splicing isoforms for
NCOA5

Expression for NCOA5 Gene

mRNA expression in normal human tissues for NCOA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA5 Gene

SOURCE GeneReport for Unigene cluster for NCOA5 Gene Hs.654991

mRNA Expression by UniProt/SwissProt for NCOA5 Gene

Q9HCD5-NCOA5_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with NCOA5: view

No data available for mRNA differential expression in normal tissues for NCOA5 Gene

Orthologs for NCOA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA5 35
  • 99.83 (n)
  • 99.83 (a)
NCOA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCOA5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA5 35
  • 93.55 (n)
  • 95.34 (a)
NCOA5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa5 35
  • 89.58 (n)
  • 92.75 (a)
Ncoa5 16
Ncoa5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA5 36
  • 23 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa5 35
  • 89.85 (n)
  • 92.56 (a)
chicken
(Gallus gallus)
Aves NCOA5 35
  • 69.51 (n)
  • 74.25 (a)
NCOA5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA5 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ncoa5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75993 35
ncoa5 35
  • 62.63 (n)
  • 65.09 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9868 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8020 35
ncoa5 35
  • 58.33 (n)
  • 57.94 (a)
ncoa5 36
  • 41 (a)
OneToOne
Species with no ortholog for NCOA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA5 Gene

ENSEMBL:
Gene Tree for NCOA5 (if available)
TreeFam:
Gene Tree for NCOA5 (if available)

Paralogs for NCOA5 Gene

No data available for Paralogs for NCOA5 Gene

Variants for NCOA5 Gene

Sequence variations from dbSNP and Humsavar for NCOA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs10774 -- 46,089,331(+) GGCGG(A/G)GGACA intron-variant
rs11164 -- 46,060,990(+) TTTTA(C/G)TTTTT utr-variant-3-prime
rs12942 -- 46,089,326(+) ACGGT(A/G)GCGGG intron-variant
rs15018 -- 46,061,245(+) CTGGG(A/G)AGAGG utr-variant-3-prime
rs15949 -- 46,061,346(+) TCTCG(A/G)GAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NCOA5 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV Loss 17160897
dgv1329e1 CNV Complex 17122850

Relevant External Links for NCOA5 Gene

HapMap Linkage Disequilibrium report
NCOA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA5 Gene

Disorders for NCOA5 Gene

Relevant External Links for NCOA5

Genetic Association Database (GAD)
NCOA5
Human Genome Epidemiology (HuGE) Navigator
NCOA5
genes like me logo Genes that share disorders with NCOA5: view

No data available for UniProtKB/Swiss-Prot for NCOA5 Gene

Publications for NCOA5 Gene

  1. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PMID: 11113208) Sauve F. … Giguere V. (Mol. Cell. Biol. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PMID: 15073177) Jiang C. … Xiao H. (J. Biol. Chem. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for NCOA5 Gene

Sources for NCOA5 Gene

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