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Aliases for NCOA5 Gene

Aliases for NCOA5 Gene

  • Nuclear Receptor Coactivator 5 2 3 5
  • Coactivator Independent Of AF-2 2 3 4
  • NCoA-5 3 4
  • CIA 3 4
  • BA465L10.6 3
  • KIAA1637 4

External Ids for NCOA5 Gene

Previous GeneCards Identifiers for NCOA5 Gene

  • GC20M044418
  • GC20M045328
  • GC20M045375
  • GC20M044123
  • GC20M044690
  • GC20M041430

Summaries for NCOA5 Gene

Entrez Gene Summary for NCOA5 Gene

  • This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCOA5 Gene

NCOA5 (Nuclear Receptor Coactivator 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and chromatin binding.

UniProtKB/Swiss-Prot for NCOA5 Gene

  • Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Wiki entry for NCOA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA5 Gene

Genomics for NCOA5 Gene

Regulatory Elements for NCOA5 Gene

Enhancers for NCOA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F045334 1.8 FANTOM5 Ensembl ENCODE 105 +747.9 747872 14.4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NCOA5 PCIF1 ZNF335 CD40 ZSWIM1 ENSG00000271984 ENSG00000233352 LOC105372630 ENSG00000237464 RPL5P2
GH20F045967 1.2 ENCODE 115.5 +119.1 119079 5.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 NCOA5 CD40 ZNF335 TP53RK PCIF1 SLC2A10 ENSG00000271984 SYS1 FTLP1 RPL13P2
GH20F045997 1.5 FANTOM5 Ensembl ENCODE 44 +90.6 90552 4.8 PKNOX1 ZFP64 ZBTB11 ZEB2 ZNF623 ZNF781 ZNF518A NR2F2 ZNF264 SMARCA4 NCOA5 CD40 ZNF335 TP53RK SLC12A5 WFDC3 ENSG00000204044 PCIF1 DNTTIP1 ENSG00000271984
GH20F045880 1.1 ENCODE 46.9 +208.7 208693 1.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 NCOA5 PCIF1 TP53RK CD40 ZNF335 WFDC3 RPS2P7 NEURL2 SLC2A10 SYS1
GH20F045777 1.6 FANTOM5 Ensembl ENCODE 23.6 +309.3 309260 5.6 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS DEK WFDC3 NCOA5 TP53RK CD40 PCIF1 ENSG00000271984 ZNF335 DNTTIP1 WFDC13 RNU6ATAC38P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCOA5 on UCSC Golden Path with GeneCards custom track

Promoters for NCOA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009781 452 2600 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for NCOA5 Gene

Chromosome:
20
Start:
46,060,985 bp from pter
End:
46,089,952 bp from pter
Size:
28,968 bases
Orientation:
Minus strand

Genomic View for NCOA5 Gene

Genes around NCOA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA5 Gene

Proteins for NCOA5 Gene

  • Protein details for NCOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCD5-NCOA5_HUMAN
    Recommended name:
    Nuclear receptor coactivator 5
    Protein Accession:
    Q9HCD5
    Secondary Accessions:
    • B2RTV9
    • E1P5R0
    • Q6HA99
    • Q9H1F2
    • Q9H2T2
    • Q9H4Y9

    Protein attributes for NCOA5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65536 Da
    Quaternary structure:
    • Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.
    SequenceCaution:
    • Sequence=AAG36793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOA5 Gene

neXtProt entry for NCOA5 Gene

Post-translational modifications for NCOA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOA5 Gene

No data available for DME Specific Peptides for NCOA5 Gene

Domains & Families for NCOA5 Gene

Protein Domains for NCOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCOA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCD5

UniProtKB/Swiss-Prot:

NCOA5_HUMAN :
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
Domain:
  • Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
genes like me logo Genes that share domains with NCOA5: view

No data available for Gene Families for NCOA5 Gene

Function for NCOA5 Gene

Molecular function for NCOA5 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Gene Ontology (GO) - Molecular Function for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 11113208
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NCOA5: view
genes like me logo Genes that share phenotypes with NCOA5: view

Animal Models for NCOA5 Gene

MGI Knock Outs for NCOA5:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA5 Gene

Localization for NCOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NCOA5: view

Pathways & Interactions for NCOA5 Gene

SuperPathways for NCOA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IBA --
GO:0042593 glucose homeostasis IEA --
GO:0046627 negative regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NCOA5: view

No data available for Pathways by source and SIGNOR curated interactions for NCOA5 Gene

Drugs & Compounds for NCOA5 Gene

(1) Drugs for NCOA5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL Experimental Pharma Target 0
genes like me logo Genes that share compounds with NCOA5: view

Transcripts for NCOA5 Gene

Unigene Clusters for NCOA5 Gene

Nuclear receptor coactivator 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NCOA5 Gene

GeneLoc Exon Structure for
NCOA5
ECgene alternative splicing isoforms for
NCOA5

Expression for NCOA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCOA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA5 Gene

This gene is overexpressed in Testis (14.8), Peripheral blood mononuclear cells (11.1), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOA5 Gene



Protein tissue co-expression partners for NCOA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCOA5 Gene:

NCOA5

SOURCE GeneReport for Unigene cluster for NCOA5 Gene:

Hs.654991

mRNA Expression by UniProt/SwissProt for NCOA5 Gene:

Q9HCD5-NCOA5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NCOA5: view

Primer Products

No data available for mRNA differential expression in normal tissues for NCOA5 Gene

Orthologs for NCOA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA5 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia NCOA5 34 35
  • 93.55 (n)
cow
(Bos Taurus)
Mammalia NCOA5 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa5 34
  • 89.85 (n)
mouse
(Mus musculus)
Mammalia Ncoa5 34 16 35
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia NCOA5 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA5 35
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA5 34 35
  • 69.51 (n)
lizard
(Anolis carolinensis)
Reptilia NCOA5 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa5 34
  • 62.63 (n)
MGC75993 34
African clawed frog
(Xenopus laevis)
Amphibia ncoa5-prov 34
zebrafish
(Danio rerio)
Actinopterygii ncoa5 34 35
  • 58.33 (n)
Dr.8020 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9868 34
Species where no ortholog for NCOA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA5 Gene

ENSEMBL:
Gene Tree for NCOA5 (if available)
TreeFam:
Gene Tree for NCOA5 (if available)

Paralogs for NCOA5 Gene

No data available for Paralogs for NCOA5 Gene

Variants for NCOA5 Gene

Sequence variations from dbSNP and Humsavar for NCOA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10485438 -- 46,079,999(+) CCAGA(A/G)TAACA intron-variant
rs10606019 -- 46,087,949(+) TTAAC(-/AG)GGGGA intron-variant
rs10626712 -- 46,076,334(+) CAAAG(-/AAG/TAG)GAGGT intron-variant
rs10774 -- 46,089,331(+) GGCGG(A/G)GGACA intron-variant
rs11086994 -- 46,088,004(+) TATAT(-/A)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA5 Gene

Variant ID Type Subtype PubMed ID
esv2758796 CNV loss 17122850
nsv1063229 CNV gain 25217958
nsv833991 CNV loss 17160897

Variation tolerance for NCOA5 Gene

Residual Variation Intolerance Score: 7.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA5 Gene

Disorders for NCOA5 Gene

Relevant External Links for NCOA5

Genetic Association Database (GAD)
NCOA5
Human Genome Epidemiology (HuGE) Navigator
NCOA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA5

No disorders were found for NCOA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCOA5 Gene

Publications for NCOA5 Gene

  1. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PMID: 11113208) Sauve F. … Giguere V. (Mol. Cell. Biol. 2001) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4 64
  3. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PMID: 20650312) Lewis J.P. … Bowden D.W. (Genomics 2010) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PMID: 15073177) Jiang C. … Xiao H. (J. Biol. Chem. 2004) 3 4 64

Products for NCOA5 Gene

Sources for NCOA5 Gene

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