NCOA4 Gene
protein-coding GIFtS: 55
GCID: GC10P051565
|
|
nuclear receptor coactivator 4
| |
Aliases
for NCOA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Coactivator 41 2 | | 70 KDa AR-Activator2 3 | | ELE11 2 3 5 | | NCoA-42 3 | | ARA701 2 3 | | DKFZp762E11121 | | RFG1 2 3 | | Ret Fused2 | | PTC31 2 5 | | RET-Activating Gene ELE12 | | Androgen Receptor-Associated Protein Of 70 KDa2 3 | | Androgen Receptor Coactivator 70 KDa Protein3 | | 70 KDa Androgen Receptor Coactivator2 3 | | Ret-Activating Protein ELE13 |
Export aliases for NCOA4 gene to outside databasesPrevious GC identifers: GC10P050408 GC10P051457 GC10P050916 GC10P051235 GC10P045675 |
Summaries
for NCOA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCOA4:
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in aligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and theret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma.Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and14. (provided by RefSeq, Feb 2009)
UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independentcoactivator of the peroxisome proliferator-activated receptor (PPAR) gamma
Gene Wiki entry for NCOA4
|
Genomic Views
for NCOA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCOA4 gene promoter:
Nkx3-1 Nkx3-1 v2 AP-1 Nkx3-1 v1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCOA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.2NCOA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P051565: view genomic region
(about GC identifiers)
Start:
|
51,565,108 bp from pter |
End:
|
51,590,734 bp from pter |
Size:
|
25,627 bases |
Orientation:
|
plus strand |
|
Proteins
for NCOA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772 (See
protein sequence)Recommended Name: Nuclear receptor coactivator 4 Size: 614 amino acids; 69726 Da
Subunit: Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner
1 PDB 3D structure from  and Proteopedia  for NCOA4:1T5Z (3D)
Secondary accessions: A8K8W5 Q14239Alternative splicing: 2 isoforms: Q13772-1 Q13772-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NCOA4: NX_Q13772
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13772
NCOA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001138732.1 NP_001138733.1 NP_001138734.1 NP_001138735.1 NP_005428.1
ENSEMBL proteins: ENSP00000363200 ENSP00000344552 ENSP00000363195 ENSP00000400928 ENSP00000405146 ENSP00000395465 ENSP00000390713 ENSP00000393053 ENSP00000411018
Human Recombinant Protein Products for NCOA4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NCOA4 for ontologies About GeneDecksing
NCOA4 Antibody Products:
Assay Products for NCOA4: |
Protein
Domains /
Families
for NCOA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCOA4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13772ProtoNet protein and cluster: Q13772 |
Function
for NCOA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCOA4_HUMAN, Q13772Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independentcoactivator of the peroxisome proliferator-activated receptor (PPAR) gamma Genatlas biochemistry entry for NCOA4:nuclear receptor coactivator 4,in transcriptional activation of target genes upon specific induction byandrogens,ligand dependent,70kDa,expressed in prostate cells,fused with RET in papillary thyroid carcinomas
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NCOA4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for NCOA4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): NCOA4 (NM_001145260) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA4 |
|
Pathways & Interactions
for NCOA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Androgen Signaling | | | 2 | Diurnally regulated genes with circadian orthologs | | | 3 | Coregulation of Androgen receptor activity | | | 4 | Pathways in cancer | | | 5 | Androgen receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NCOA4
3  BioSystems Pathways for NCOA4
2 
Kegg Pathways (Kegg details for NCOA4):
NCOA4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/18 Interacting proteins for NCOA4 (Q137722, 3 ENSP000003954654) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NCOA4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCOA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCOA4 for compounds About GeneDecksing
 Browse Tocris compounds for NCOA4
10/11 Novoseek chemical compound relationships for NCOA4 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydroxyflutamide |
88.8 |
11 |
15166229 (1), 10405524 (1), 11501969 (1), 8643607 (1) (see all 5) |
| testosterone |
70.9 |
52 |
12068007 (5), 11161850 (3), 8643607 (3), 10517667 (3) (see all 21) |
| dihydrotestosterone |
64.7 |
5 |
9576916 (1), 8643607 (1), 18649734 (1) |
| bicalutamide |
62.5 |
2 |
9636157 (1) |
| cyproteroneacetate |
47.8 |
1 |
9636157 (1) |
| steroid |
42.2 |
6 |
9576916 (1), 12750261 (1), 10517667 (1), 15663989 (1) |
| estrogen |
32.7 |
6 |
15772083 (2), 16677694 (1), 9892017 (1), 12068007 (1) |
| tyrosine |
29.4 |
3 |
11313992 (1), 8806700 (1), 8290261 (1) |
| chloramphenicol |
16 |
1 |
9636157 (1) |
| estradiol |
14.6 |
4 |
12068007 (2), 17011702 (1) |
Search CenterWatch for drugs/clinical trials and news about NCOA4
|
Transcripts
for NCOA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCOA4 gene (5 alternative transcripts): NM_001145260.1 NM_001145261.1 NM_001145262.1 NM_001145263.1 NM_005437.3 Unigene Clusters for NCOA4: Nuclear receptor coactivator 4 Hs.643658 [show with all ESTs], Hs.709644 [show with all ESTs]Unigene Representative Sequences: NM_001145260, AK13061210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000498586 ENST00000374087 ENST00000344348(uc001jit.3) ENST00000374082
ENST00000431200 ENST00000438493(uc010qhd.2 uc001jis.4 uc010qhe.2 uc010qhf.2)
ENST00000452682(uc009xon.3) ENST00000443446(uc009xoo.3) ENST00000430396
ENST00000414907
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): NCOA4 (NM_001145260) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA4 |
Additional cDNA sequence: AK130612.1 AY425959.1 24/56 DOTS entries (see all 56): DT.121281616 DT.100034718 DT.121281495 DT.97798931 DT.92460214 DT.92051119 DT.100882171 DT.121281514 DT.85104228 DT.121281862 DT.121281794 DT.100834475 DT.100882160 DT.100772240 DT.102840054 DT.121281626 DT.100882161 DT.92460209 DT.121281548 DT.95173903 DT.320089 DT.121281787 DT.121281871 DT.95173911 24/661 AceView cDNA sequences (see all 661): AA281523 AW189176 BX358528 AA205170 BU152911 AW468400 BU789980 AA305060 AI640405 AA912051 AK129911 BQ959208 CR595011 AA961986 AI242397 N90058 AA758599 AA808645 BP366842 BF590713 CB992338 BX365454 AU134555 AA318713
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA4 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCOA4
|
Expression
for NCOA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCOA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCAAAAT
About this image
See NCOA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCOA4
SOURCE GeneReport for Unigene clusters: Hs.643658 Hs.709644
UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772Tissue specificity: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta isonly expressed in testis
SABiosciences Expression via Pathway-Focused PCR Array including NCOA4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA4 |
Orthologs
for NCOA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NCOA4 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for NCOA4 (if available)
TreeFam Gene Tree for NCOA4 (if available) |
Paralogs
for NCOA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCOA4 gene
NCOA4 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for NCOA4
PGOHUM00000247833 PGOHUM00000245621 PGOHUM00000245721 PGOHUM00000260094
|
Genomic Variants
for NCOA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCOA4 (51565108 - 51590734 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NCOA4
1 CNV: 3800 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA4 |
|
Disorders
/ Diseases
for NCOA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCOA4 for disorders About GeneDecksing
OMIM gene information: 601984
OMIM disorders: 188550
UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772
Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of thethyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillarycarcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections offibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberrationinvolving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4(PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas
15  diseases for NCOA4: About MalaCardspapillary thyroid carcinoma thyroid carcinoma thyroiditis carcinoma
papillary carcinoma thyroid cancer ovarian cancer azoospermia
prostate cancer breast cancer alzheimer's disease prostatitis
prostate carcinoma ataxia cholesterol
10/11 Novoseek disease relationships for NCOA4 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thyroid papillary carcinoma |
80.4 |
5 |
9192845 (1), 11318605 (1), 9528832 (1), 10083732 (1) (see all 5) |
| prostate cancer |
55.6 |
20 |
15166229 (4), 12649293 (3), 10405524 (2), 11501969 (2) (see all 9) |
| withdrawal syndrome |
53.8 |
2 |
15166229 (1) |
| carcinoma papillary |
43.3 |
2 |
9192845 (1), 10597232 (1) |
| thyroid cancer |
42.9 |
3 |
8806700 (1), 16331264 (1) |
| thyroid carcinoma |
39.3 |
1 |
10597232 (1) |
| tumors |
32.5 |
16 |
9192845 (2), 11561770 (2), 11161850 (2), 15166229 (1) (see all 9) |
| mammary tumor |
25.6 |
1 |
10517667 (1) |
| carcinoma |
14.9 |
2 |
11561770 (1), 11161850 (1) |
| ovarian cancer |
3.63 |
6 |
11161850 (2) |
Human Genome Epidemiology (HuGE) Navigator: NCOA4 (7 documents)
Export disorders for NCOA4 gene to outside databases
|
Publications
for NCOA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCOA4 gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with NCOA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. (PubMed id 8643607)1, 2, 3, 9 Yeh S. and Chang C. (1996)
- Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. (PubMed id 8290261)1, 2, 3, 9 Santoro M.... Fusco A. (1994)
- Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. (PubMed id 10347167)1, 2, 9 Heinlein C.A.... Chang C. (1999)
- Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. (PubMed id 8187085)1, 2, 9 Bongarzone I.... Pierotti M.A. (1994)
- Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. (PubMed id 9892017)1, 2, 9 Alen P.... Peeters B. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays. (PubMed id 10517667)1, 9 Gao T....McPhaul M.J. (1999)
- Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells. (PubMed id 12649293)1, 9 Rahman M.M....Chang C. (2003)
- Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. (PubMed id 12068007)1, 9 Thin T.H....Chang C. (2002)
- Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells. (PubMed id 15772083)1, 9 Lanzino M....Ando S. (2005)
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External Searches for NCOA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NCOA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NCOA4 gene
(According to HUGE)
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Specialized Databases showing NCOA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for NCOA4 gene:
Search GeneIP for patents involving NCOA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NCOA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NCOA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA4 | | | OriGene Protein Over-expression Lysate for NCOA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCOA4 | | OriGene 3'-UTR Clone for NCOA4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NCOA4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCOA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA4 |
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| | | | Search Tocris compounds for NCOA4 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA4 |
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