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NCOA4 Gene

protein-coding   GIFtS: 59
GCID: GC10P051565

Nuclear Receptor Coactivator 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Coactivator 41 2     NCoA-42 3
ELE12 3 5     RFG2 3
RET-Activating Gene ELE11 2     PTC32 5
Androgen Receptor-Associated Protein Of 70 KDa2 3     Ret Fused2
70 KDa Androgen Receptor Coactivator2 3     Androgen Receptor Coactivator 70 KDa Protein3
70 KDa AR-Activator2 3     Ret-Activating Protein ELE13
ARA702 3     

External Ids:    HGNC: 76711   Entrez Gene: 80312   Ensembl: ENSG000001382937   OMIM: 6019845   UniProtKB: Q137723   

Export aliases for NCOA4 gene to outside databases

Previous GC identifers: GC10P050408 GC10P051457 GC10P050916 GC10P051235 GC10P045675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCOA4 Gene:
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a
ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and
the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid
carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes
4, 5, 10, and 14. (provided by RefSeq, Feb 2009)

GeneCards Summary for NCOA4 Gene:
NCOA4 (nuclear receptor coactivator 4) is a protein-coding gene. Diseases associated with NCOA4 include papillary thyroid carcinoma, and follicular thyroid carcinoma. GO annotations related to this gene include transcription coactivator activity and androgen receptor binding.

UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772
Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent
coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma

Gene Wiki entry for NCOA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCOA4 gene promoter:
         Nkx3-1   Nkx3-1 v2   AP-1   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NCOA4 promoter sequence
   Search Chromatin IP Primers for NCOA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCOA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

NCOA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P051565:  view genomic region     (about GC identifiers)

Start:
51,565,108 bp from pter      End:
51,590,734 bp from pter
Size:
25,627 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 4  
Size: 614 amino acids; 69726 Da
Subunit: Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner
1 PDB 3D structure from and Proteopedia for NCOA4:
1T5Z (3D)    
Secondary accessions: A8K8W5 B4E260 E9PAV7 J3KQN8 Q14239
Alternative splicing: 4 isoforms:  Q13772-1   Q13772-2   Q13772-3   Q13772-4   (No experimental confirmation available. Ref.3 (AK310849) sequence is in conflict in position: 8:F->V)

Explore the universe of human proteins at neXtProt for NCOA4: NX_Q13772

Explore proteomics data for NCOA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys181, Lys255, Lys271, Lys343, Lys356, Lys367, Lys377, Lys424, Lys465, Lys472,
                                 Lys490, Lys545, Lys558
  • Modification sites at PhosphoSitePlus

  • See NCOA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138732.1  NP_001138733.1  NP_001138734.1  NP_001138735.1  NP_005428.1  

    ENSEMBL proteins: 
     ENSP00000363200   ENSP00000344552   ENSP00000363195   ENSP00000400928   ENSP00000405146  
     ENSP00000395465   ENSP00000390713   ENSP00000393053   ENSP00000411018  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022174 ARA70

    Graphical View of Domain Structure for InterPro Entry Q13772

    ProtoNet protein and cluster: Q13772


    NCOA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA4_HUMAN, Q13772
    Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent
    coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma

         Genatlas biochemistry entry for NCOA4:
    nuclear receptor coactivator 4,in transcriptional activation of target genes upon specific induction by
    androgens,ligand dependent,70kDa,expressed in prostate cells,fused with RET in papillary thyroid carcinomas

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0050681androgen receptor binding NAS15572661
         
    NCOA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCOA4:
     Increased cell death in HCT116 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCOA4
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    miRNA
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    miRTarBase miRNAs that target NCOA4:
    hsa-mir-93-3p (MIRT038845), hsa-mir-484 (MIRT041830), hsa-mir-365a-3p (MIRT044019)

    Block miRNA regulation of human, mouse, rat NCOA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCOA4 (see all 19):
    hsa-miR-3934 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-501-3p hsa-miR-502-3p hsa-miR-1297 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidNCOA4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8643607

    NCOA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCOA4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Androgen Signaling
    Androgen Signaling0.52
    2Thyroid cancer
    Thyroid cancer
    3Pathways in cancer
    Pathways in cancer
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NCOA4
        Androgen Signaling

    3 BioSystems Pathways for NCOA4
        Diurnally regulated genes with circadian orthologs
    Androgen receptor signaling pathway
    Coregulation of Androgen receptor activity


    2 Kegg Pathways  (Kegg details for NCOA4):
        Pathways in cancer
    Thyroid cancer


    NCOA4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NCOA4: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCOA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for NCOA4 (Q137722, 3 ENSP000003954654) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN2Q997002, 3, ENSP000003668434MINT-2864727 I2D: score=3 STRING: ENSP00000366843
    ARP102753, ENSP000003638224I2D: score=4 STRING: ENSP00000363822
    RNF14Q9UBS83, ENSP000003249564I2D: score=2 STRING: ENSP00000324956
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    PPARGP372313, ENSP000002878204I2D: score=2 STRING: ENSP00000287820
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008584male gonad development TAS8643607
    GO:0009725response to hormone IEA--
    GO:0030521androgen receptor signaling pathway NAS15572661
    GO:0045893positive regulation of transcription, DNA-templated NAS15572661

    NCOA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCOA4

    Selected Novoseek inferred chemical compound relationships for NCOA4 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyflutamide 88.8 11 15166229 (1), 10405524 (1), 11501969 (1), 8643607 (1) (see all 5)
    testosterone 70.9 52 12068007 (5), 11161850 (3), 8643607 (3), 10517667 (3) (see all 21)
    dihydrotestosterone 64.7 5 9576916 (1), 8643607 (1), 18649734 (1)
    bicalutamide 62.5 2 9636157 (1)
    cyproteroneacetate 47.8 1 9636157 (1)
    steroid 42.2 6 9576916 (1), 12750261 (1), 10517667 (1), 15663989 (1)
    estrogen 32.7 6 15772083 (2), 16677694 (1), 9892017 (1), 12068007 (1)
    tyrosine 29.4 3 11313992 (1), 8806700 (1), 8290261 (1)
    chloramphenicol 16 1 9636157 (1)
    estradiol 14.6 4 12068007 (2), 17011702 (1)



    NCOA4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NCOA4 gene (5 alternative transcripts): 
    NM_001145260.1  NM_001145261.1  NM_001145262.1  NM_001145263.1  NM_005437.3  

    Unigene Cluster for NCOA4:

    Nuclear receptor coactivator 4
    Hs.643658  [show with all ESTs]
    Unigene Representative Sequence: NM_001145260
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498586 ENST00000374087 ENST00000344348(uc001jit.3) ENST00000374082
    ENST00000431200 ENST00000438493(uc010qhd.2 uc001jis.4 uc010qhe.2 uc010qhf.2)
    ENST00000452682(uc009xon.3) ENST00000443446(uc009xoo.3) ENST00000430396
    ENST00000414907

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCOA4 (see all 19):
    hsa-miR-3934 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-501-3p hsa-miR-502-3p hsa-miR-1297 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidNCOA4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NCOA4
      QuantiFast Probe-based Assays in human, mouse, rat NCOA4

    Additional mRNA sequence: 

    AB064669.1 AK129911.1 AK292480.1 AK293978.1 AK302794.1 AK304123.1 AK310849.1 AK312325.1 
    AL162047.1 AY425959.1 BC001562.1 BC012736.2 L49399.1 X71413.1 X77548.1 

    Selected DOTS entries (see all 56):

    DT.121281616  DT.100034718  DT.121281495  DT.97798931  DT.92460214  DT.92051119  DT.100882171  DT.121281514 
    DT.85104228  DT.121281862  DT.121281794  DT.100834475  DT.100882160  DT.100772240  DT.102840054  DT.121281626 
    DT.92460209  DT.121281548  DT.95173903  DT.100882161  DT.320089  DT.121281787  DT.121281871  DT.95173911 

    Selected AceView cDNA sequences (see all 661):

    CB306938 BU178668 AA846870 BQ439949 CA438163 AL038145 CB164128 BU734609 
    CA417610 CB995873 BM669603 AI453156 AA704658 AU133484 N20471 AA704397 
    AU118273 AW970207 Z41751 AA281523 AK130612 BM767045 F04437 AV657364 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCOA4 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                                              -     -     -           -     -                 -                                             
    SP2:                                            -     -     -     -     -     -           -     -                 -                                             
    SP3:                                                                                      -     -                 -                                             
    SP4:                                                                                      -     -                 -                                             
    SP5:                                      -     -     -     -     -     -     -           -     -                 -                                             

    ExUns: 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for NCOA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCOA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCAAAAT
    NCOA4 Expression
    About this image

    NCOA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCOA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643658

    UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772
    Tissue specificity: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta
    is only expressed in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including NCOA4: 
              Nuclear Receptors & Coregulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa41 , 5 nuclear receptor coactivator 41, 5 83.71(n)1
    80.72(a)1
      14 (19.40 cM)5
    270571  NM_001033988.21  NP_001029160.11 
     321598655 
    chicken
    (Gallus gallus)
    Aves NCOA41 nuclear receptor coactivator 4 62.39(n)
    55.11(a)
      423615  NM_001006495.1  NP_001006495.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA46
    nuclear receptor coactivator 4
    52(a)
    1 ↔ 1
    AAWZ02040015(21-7461)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81132 Xenopus laevis, clone IMAGE4683997, mRNA 74.33(n)    BC046870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC047166.12   -- 76.35(n)   394104  BC047166.1 


    ENSEMBL Gene Tree for NCOA4 (if available)
    TreeFam Gene Tree for NCOA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCOA4 gene

    NCOA4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NCOA4
    PGOHUM00000247833 PGOHUM00000245621 PGOHUM00000245721 PGOHUM00000260094


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCOA4 (see all 650)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001938811,2
    C--51564491(+) GAAAA-/GAAAA 
            
    AAAGA
    3 -- us2k10--------
    rs2006468841,2
    C--51565362(+) GTCCGA/CCNNNN 3 -- int10--------
    rs1999894801,2
    C--51583021(-) TTAACA/GANNNN 5 -- int10--------
    rs750488561,2
    C--51584374(+) AAAAA-/A/AA  
            
    TTAGC
    5 -- int10--------
    rs776788631,2
    C,F--51587140(+) CCATGT/CTGCTG 5 -- int13Minor allele frequency- C:0.04MN CSA WA 260
    rs561486351,2
    C,F--51587237(+) CTCAAG/AAAATC 5 -- int12Minor allele frequency- A:0.05MN NA 258
    rs104000871,2
    C,F,H--51948173(+) TTTACG/AGTGTT 3 -- us2k111Minor allele frequency- A:0.04NS EA NA CSA WA 1206
    rs759336691,2
    C,F--51948384(+) GCCTTG/TCAGAT 3 -- us2k13Minor allele frequency- T:0.10MN WA NA 374
    rs782671361,2
    C,F--51948385(+) CCTTGC/TAGATG 3 -- us2k13Minor allele frequency- T:0.10MN WA NA 374
    rs775889131,2
    C--51948455(+) GAAAAA/CTTAGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCOA4 (51565108 - 51590734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NCOA4 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508583CNV Loss20534489
    nsv895383CNV Loss21882294
    nsv521269CNV Gain19592680
    nsv895385CNV Gain21882294
    nsv470936CNV Gain18288195
    dgv702n71CNV Gain21882294
    nsv518071CNV Gain19592680
    nsv895388CNV Gain21882294
    nsv467192CNV Gain19166990
    nsv428232CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCOA4
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601984   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: NCOA4_HUMAN, Q13772
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas.
    Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and
    radiation-associated post-Chernobyl thyroid papillary carcinomas

  • 14 diseases for NCOA4:    
    About MalaCards
    papillary thyroid carcinoma    follicular thyroid carcinoma    papillary carcinoma    thyroid cancer
    thyroiditis    azoospermia    prostate cancer    ovarian cancer
    prostatitis    ataxia    breast cancer    alzheimer's disease
    multiple myeloma    myeloma


    NCOA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for NCOA4 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 80.4 5 9192845 (1), 11318605 (1), 9528832 (1), 10083732 (1) (see all 5)
    prostate cancer 55.6 20 15166229 (4), 12649293 (3), 10405524 (2), 11501969 (2) (see all 9)
    withdrawal syndrome 53.8 2 15166229 (1)
    carcinoma papillary 43.3 2 9192845 (1), 10597232 (1)
    thyroid cancer 42.9 3 8806700 (1), 16331264 (1)
    thyroid carcinoma 39.3 1 10597232 (1)
    tumors 32.5 16 9192845 (2), 11561770 (2), 11161850 (2), 15166229 (1) (see all 9)
    mammary tumor 25.6 1 10517667 (1)
    carcinoma 14.9 2 11561770 (1), 11161850 (1)
    ovarian cancer 3.63 6 11161850 (2)

    Genetic Association Database (GAD): NCOA4
    Human Genome Epidemiology (HuGE) Navigator: NCOA4 (7 documents)

    Export disorders for NCOA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCOA4 gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with NCOA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. (PubMed id 8643607)1, 2, 3, 9 Yeh S. and Chang C. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. (PubMed id 8290261)1, 2, 3, 9 Santoro M.... Fusco A. (Oncogene 1994)
    3. Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. (PubMed id 10347167)1, 2, 9 Heinlein C.A.... Chang C. (J. Biol. Chem. 1999)
    4. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. (PubMed id 8187085)1, 2, 9 Bongarzone I.... Pierotti M.A. (Cancer Res. 1994)
    5. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. (PubMed id 9892017)1, 2, 9 Alen P.... Peeters B. (Mol. Endocrinol. 1999)
    6. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. (PubMed id 20717903)1, 4 Wang Y....Lange E.M. (Prostate 2011)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8031 HGNC: 7671 AceView: NCOA4 Ensembl:ENSG00000138293 euGenes: HUgn8031
    ECgene: NCOA4 Kegg: 8031 H-InvDB: NCOA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCOA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCOA4 gene:
    Search GeneIP for patents involving NCOA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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