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Aliases for NCOA3 Gene

Aliases for NCOA3 Gene

  • Nuclear Receptor Coactivator 3 2 3
  • Thyroid Hormone Receptor Activator Molecule 1 2 3 4
  • Receptor-Associated Coactivator 3 2 3 4
  • Class E Basic Helix-Loop-Helix Protein 42 3 4
  • Steroid Receptor Coactivator Protein 3 3 4
  • Amplified In Breast Cancer 1 Protein 3 4
  • CBP-Interacting Protein 3 4
  • EC 2.3.1.48 4 63
  • BHLHe42 3 4
  • TRAM-1 3 4
  • AIB-1 3 4
  • SRC-3 3 4
  • ACTR 3 4
  • AIB1 3 4
  • RAC3 3 4
  • PCIP 3 4
  • CAGH16 3
  • KAT13B 3
  • TNRC14 3
  • TNRC16 3
  • NCoA-3 4
  • CTG26 3
  • RAC-3 4
  • TRAM1 4
  • SRC3 3

External Ids for NCOA3 Gene

Previous GeneCards Identifiers for NCOA3 Gene

  • GC20P045859
  • GC20P046769
  • GC20P046816
  • GC20P045564
  • GC20P046130
  • GC20P042872

Summaries for NCOA3 Gene

Entrez Gene Summary for NCOA3 Gene

  • The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for NCOA3 Gene

NCOA3 (Nuclear Receptor Coactivator 3) is a Protein Coding gene. Diseases associated with NCOA3 include meningothelial meningioma and estrogen-receptor positive breast cancer. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is NCOA2.

UniProtKB/Swiss-Prot for NCOA3 Gene

  • Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit

Gene Wiki entry for NCOA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA3 Gene

Genomics for NCOA3 Gene

Regulatory Elements for NCOA3 Gene

Transcription factor binding sites by QIAGEN in the NCOA3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCOA3 Gene

Chromosome:
20
Start:
47,501,857 bp from pter
End:
47,656,877 bp from pter
Size:
155,021 bases
Orientation:
Plus strand

Genomic View for NCOA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA3 Gene

Proteins for NCOA3 Gene

  • Protein details for NCOA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q9-NCOA3_HUMAN
    Recommended name:
    Nuclear receptor coactivator 3
    Protein Accession:
    Q9Y6Q9
    Secondary Accessions:
    • A4LAZ5
    • Q0VF45
    • Q5JYD9
    • Q5JYE0
    • Q9BR49
    • Q9UPC9
    • Q9UPG4
    • Q9UPG7

    Protein attributes for NCOA3 Gene

    Size:
    1424 amino acids
    Molecular mass:
    155293 Da
    Quaternary structure:
    • Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5. Interacts with PSMB9. Interacts with NPAS2. Interacts with NR4A3 (By similarity).
    Miscellaneous:
    • NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers

    Three dimensional structures from OCA and Proteopedia for NCOA3 Gene

    Alternative splice isoforms for NCOA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOA3 Gene

Proteomics data for NCOA3 Gene at MOPED

Post-translational modifications for NCOA3 Gene

  • Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
  • Methylated by CARM1.
  • Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
  • Ubiquitination at Lys 316
  • Modification sites at PhosphoSitePlus

Other Protein References for NCOA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCOA3 (SRC-3)

Domains & Families for NCOA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q9

UniProtKB/Swiss-Prot:

NCOA3_HUMAN :
  • Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain)
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
Domain:
  • Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain)
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
genes like me logo Genes that share domains with NCOA3: view

Function for NCOA3 Gene

Molecular function for NCOA3 Gene

GENATLAS Biochemistry:
nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell lines,1,possessing an intrinsic histone acetyltransferase activity,interacting with CREBBP and PCAF,stimulating gene expression in a hormone dependent fashion,by facilitating the assembly of basal transcription factors into a stable preinitiation complex
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot EnzymeRegulation:
Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D
UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit

Enzyme Numbers (IUBMB) for NCOA3 Gene

Gene Ontology (GO) - Molecular Function for NCOA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IEA --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004402 histone acetyltransferase activity IDA 9267036
genes like me logo Genes that share ontologies with NCOA3: view
genes like me logo Genes that share phenotypes with NCOA3: view

Animal Models for NCOA3 Gene

MGI Knock Outs for NCOA3:

Animal Model Products

miRNA for NCOA3 Gene

miRTarBase miRNAs that target NCOA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NCOA3 Gene

Localization for NCOA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA3 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA3 Gene COMPARTMENTS Subcellular localization image for NCOA3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NCOA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 15831516
GO:0005634 nucleus IDA 17223341
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17223341
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with NCOA3: view

Pathways & Interactions for NCOA3 Gene

genes like me logo Genes that share pathways with NCOA3: view

PCR Array Products

SIGNOR curated interactions for NCOA3 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0010628 positive regulation of gene expression IMP 17223341
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with NCOA3: view

Drugs & Compounds for NCOA3 Gene

(17) Drugs for NCOA3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cholecalciferol Approved Nutra Fat-soluble secosteroids 755,762
Estradiol Approved, Investigational Pharma Sex hormone 1057
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Raloxifene Approved, Investigational Pharma Antagonist 62
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341

(8) Additional Compounds for NCOA3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
butyrate
Cycloheximide
Phosphatidylinositol
polysaccharide
genes like me logo Genes that share compounds with NCOA3: view

Transcripts for NCOA3 Gene

Unigene Clusters for NCOA3 Gene

Nuclear receptor coactivator 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:

Relevant External Links for NCOA3 Gene

GeneLoc Exon Structure for
NCOA3
ECgene alternative splicing isoforms for
NCOA3

Expression for NCOA3 Gene

mRNA expression in normal human tissues for NCOA3 Gene

Protein differential expression in normal tissues from HIPED for NCOA3 Gene

This gene is overexpressed in Heart (33.1), Blymphocyte (10.5), Peripheral blood mononuclear cells (7.3), and Adipocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA3 Gene



SOURCE GeneReport for Unigene cluster for NCOA3 Gene Hs.592142

mRNA Expression by UniProt/SwissProt for NCOA3 Gene

Q9Y6Q9-NCOA3_HUMAN
Tissue specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney
genes like me logo Genes that share expression patterns with NCOA3: view

Protein tissue co-expression partners for NCOA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NCOA3 Gene

Orthologs for NCOA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCOA3 35
  • 88.98 (n)
  • 90.6 (a)
NCOA3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa3 35
  • 83.85 (n)
  • 85.28 (a)
Ncoa3 16
Ncoa3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCOA3 35
  • 99.53 (n)
  • 99.51 (a)
NCOA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa3 35
  • 83.37 (n)
  • 83.79 (a)
dog
(Canis familiaris)
Mammalia NCOA3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA3 35
  • 74.62 (n)
  • 77.35 (a)
NCOA3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA3 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa3 35
  • 70.15 (n)
  • 73.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398021 35
zebrafish
(Danio rerio)
Actinopterygii ncoa3 35
  • 59.93 (n)
  • 58.52 (a)
ncoa3 36
  • 49 (a)
OneToOne
Species with no ortholog for NCOA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA3 Gene

ENSEMBL:
Gene Tree for NCOA3 (if available)
TreeFam:
Gene Tree for NCOA3 (if available)

Paralogs for NCOA3 Gene

Paralogs for NCOA3 Gene

(2) SIMAP similar genes for NCOA3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NCOA3 Gene

genes like me logo Genes that share paralogs with NCOA3: view

Variants for NCOA3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA3 Gene

Q9Y6Q9-NCOA3_HUMAN
The length of the poly-Gln region is polymorphic in the normal population

Sequence variations from dbSNP and Humsavar for NCOA3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11271 -- 47,653,019(+) TGGGA(A/C)AGATG missense, reference
rs12273 -- 47,655,658(+) AACCA(A/G)GTCAG utr-variant-3-prime
rs14189 -- 47,655,650(+) AGAGG(A/T)AGAAC utr-variant-3-prime
rs365602 -- 47,641,880(+) GTTTT(C/T)GTGAG intron-variant
rs366442 -- 47,641,910(+) TCCCT(A/T)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA3 Gene

Variant ID Type Subtype PubMed ID
esv33497 CNV Loss 17666407
nsv912907 CNV Gain 21882294
nsv912908 CNV Gain 21882294
nsv833995 CNV Loss 17160897
nsv509772 CNV Insertion 20534489
nsv527945 CNV Loss 19592680
dgv100n6 CNV Loss 16902084
dgv1333e1 CNV Complex 17122850

Variation tolerance for NCOA3 Gene

Residual Variation Intolerance Score: 14.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.66; 89.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA3 Gene

HapMap Linkage Disequilibrium report
NCOA3
Human Gene Mutation Database (HGMD)
NCOA3

PCR Panel Products

Disorders for NCOA3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NCOA3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
meningothelial meningioma
  • meningotheliomatous meningioma
estrogen-receptor positive breast cancer
urethral intrinsic sphincter deficiency
  • intrinsic sphincter deficiency
breast cancer
  • breast cancer, invasive ductal
endometrial cancer
  • endometrial cancer, familial
- elite association
Search NCOA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOA3

Genetic Association Database (GAD)
NCOA3
Human Genome Epidemiology (HuGE) Navigator
NCOA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA3
genes like me logo Genes that share disorders with NCOA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA3 Gene

Publications for NCOA3 Gene

  1. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PMID: 9252329) Anzick S.L. … Meltzer P.S. (Science 1997) 2 23 67
  2. Global characterization of transcriptional impact of the SRC-3 coregulator. (PMID: 20181721) Lanz R.B. … O'Malley B.W. (Mol. Endocrinol. 2010) 23 67
  3. Aryl hydrocarbon receptor functions as a potent coactivator of E2F1-dependent trascription activity. (PMID: 20190398) Watabe Y. … Shimba S. (Biol. Pharm. Bull. 2010) 23 67
  4. Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor. (PMID: 20392877) Karmakar S. … Smith C.L. (Mol. Endocrinol. 2010) 23 67
  5. BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms. (PMID: 19360465) Jakubowska A. … Hamann U. (Breast Cancer Res. Treat. 2010) 23 67

Products for NCOA3 Gene

Sources for NCOA3 Gene

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