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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA3 Gene

protein-coding   GIFtS: 69
GCID: GC20P046130

Nuclear Receptor Coactivator 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Coactivator 31 2     CBP-Interacting Protein2 3
Receptor-Associated Coactivator 31 2 3     pCIP2 3
Thyroid Hormone Receptor Activator Molecule 11 2 3     EC 2.3.1.483 8
AIB12 3 5     TNRC142 5
Amplified In Breast Cancer 1 Protein2 3     CAGH162
Class E Basic Helix-Loop-Helix Protein 422 3     CTG262
Steroid Receptor Coactivator Protein 32 3     KAT13B2
ACTR2 3     SRC32
AIB-12 3     TNRC162
RAC32 3     BHLHE423
SRC-32 3     NCoA-33
TRAM-12 3     RAC-33
bHLHe422 3     TRAM13

External Ids:    HGNC: 76701   Entrez Gene: 82022   Ensembl: ENSG000001241517   OMIM: 6019375   UniProtKB: Q9Y6Q93   

Export aliases for NCOA3 gene to outside databases

Previous GC identifers: GC20P045859 GC20P046769 GC20P046816 GC20P045564 GC20P042872


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCOA3 Gene:
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors
to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity
and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex.
This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation.
Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic
repeat region is found in the C-terminus of the encoded protein. (provided by RefSeq, Mar 2010)

GeneCards Summary for NCOA3 Gene: 
NCOA3 (nuclear receptor coactivator 3) is a protein-coding gene. Diseases associated with NCOA3 include megaesophagus, and breast cancer, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and Axon guidance. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is NCOA1.

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex,
which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors,
such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and
prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the
NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9

summary for NCOA3 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for NCOA3 (Nuclear receptor coactivator 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA3 gene promoter:
         AP-1   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCOA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCOA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12

NCOA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P046130:  view genomic region     (about GC identifiers)

Start:
46,130,601 bp from pter      End:
46,285,621 bp from pter
Size:
155,021 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 3  
Size: 1424 amino acids; 155293 Da
Subunit: Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the
histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this
interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5
Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and
subsequent phosphorylation, it translocates from the cytoplasm to the nucleus
Miscellaneous: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers
3 PDB 3D structures from and Proteopedia for NCOA3:
1KBH (3D)        3L3X (3D)        3L3Z (3D)    
Secondary accessions: A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7
Alternative splicing: 5 isoforms:  Q9Y6Q9-1   Q9Y6Q9-2   Q9Y6Q9-3   Q9Y6Q9-4   Q9Y6Q9-5   

Explore the universe of human proteins at neXtProt for NCOA3: NX_Q9Y6Q9

Explore proteomics data for NCOA3 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors
    and regulates its function
  • UniProtKB: Methylated by CARM1 (By similarity)
  • UniProtKB: Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator
    function
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6Q9

  • 4/9 DME Specific Peptides for NCOA3 (Q9Y6Q9) (see all 9)
     EKRRREQE  IRRCIQRF  SHTFNCRML  MPQAPPQQF 

    NCOA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCOA3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001167558.1  NP_001167559.1  NP_006525.2  NP_858045.1  

    ENSEMBL proteins: 
     ENSP00000361073   ENSP00000361066   ENSP00000361065   ENSP00000342123  
    Reactome Protein details: Q9Y6Q9
    Human Recombinant Protein Products for NCOA3: 
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    OriGene Protein Over-expression Lysate for NCOA3
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for NCOA3
    Novus Biologicals NCOA3 Protein
    Novus Biologicals NCOA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    NCOA3 for ontologies           About GeneDecksing



    NCOA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NCOA3
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    Cell Signaling Technology (CST) Antibodies for NCOA3  (SRC-3)
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    GenScript Custom Superior Antibodies Services for NCOA3
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    Abcam antibodies for NCOA3
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    LSBio Antibodies in human, mouse, rat for NCOA3 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCOA3 
    Cloud-Clone Corp. CLIAs for NCOA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    bHLH: Basic helix-loop-helix proteins

    5/9 InterPro protein domains (see all 9):
     IPR008955 Src1_rcpt_coact
     IPR010011 DUF1518
     IPR014935 SRC-1
     IPR014920 Nuc_rcpt_coact_Ncoa-typ
     IPR009110 Nuc_rcpt_coact

    Graphical View of Domain Structure for InterPro Entry Q9Y6Q9

    ProtoNet protein and cluster: Q9Y6Q9

    4 Blocks protein domains:
    IPB000014 PAS domain
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB010011 Protein of unknown function DUF1518
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
    Domain: Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with
    nuclear receptors, and constitute the RID domain (Receptor-interacting domain)
    Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    NCOA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA3_HUMAN, Q9Y6Q9
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex,
    which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors,
    such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and
    prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the
    NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
    Enzyme regulation: Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various
    hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn
    activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target
    genes by disrupting its association with nuclear receptors. Binds to CSNK1D

         Genatlas biochemistry entry for NCOA3:
    nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell lines,1,possessing an intrinsic
    histone acetyltransferase activity,interacting with CREBBP and PCAF,stimulating gene expression in a hormone
    dependent fashion,by facilitating the assembly of basal transcription factors into a stable preinitiation complex

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
    GO:0004402histone acetyltransferase activity IDA9267036
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI11250900
         
    NCOA3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NCOA3:
     Increased cell number in G1, s  Synthetic lethal with imatinib  Upregulation of Wnt/beta-caten 

         15/20 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ncoa3) (see all 20):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    NCOA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NCOA3: Ncoa3tm2.2Jxu Ncoa3tm1Rsd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NCOA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCOA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCOA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCOA3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCOA3:
    hsa-mir-98 (MIRT004305), hsa-mir-19b (MIRT004310), hsa-mir-21 (MIRT004306), hsa-mir-18a (MIRT004311), hsa-mir-17 (MIRT005408), hsa-mir-29b (MIRT004312)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA3
    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA3 (see all 139):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-519a hsa-miR-3916 hsa-miR-1243 hsa-miR-3116 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NCOA3 (NM_006534)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA3
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                         Customized lentivirus expression plasmids for stable overexpression of NCOA3 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCOA3 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    Crosstalk Between CARM1 and ESRs0.39
    2Axon guidance
    Developmental Biology0.69
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4GPCR Pathway
    Estrogen Pathway0.55
    5Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for NCOA3
        Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Development Ligand-independent activation of ESR1 and ESR2
    Transcription Ligand-dependent activation of the ESR1/SP pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOA3 (see all 6)
        AHR Pathway
    Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 Cell Signaling Technology (CST) Pathway for NCOA3
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for NCOA3
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 BioSystems Pathways for NCOA3
        Integrated Breast Cancer Pathway
    Androgen receptor signaling pathway
    Retinoic acid receptors-mediated signaling
    FOXA1 transcription factor network

    2        Reactome Pathways for NCOA3
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation

    1 PharmGKB Pathway for NCOA3
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics


    NCOA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/224 Interacting proteins for NCOA3 (Q9Y6Q91, 2, 3 ENSP000003610664) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000239836P280652, 3, ENSP000003968134MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 STRING: ENSP00000396813
    PSMB9P280652, 3, ENSP000003639934MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 STRING: ENSP00000363993
    ENSG00000240118P280652, 3MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    ENSG00000240508P280652, 3MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    ENSG00000242711P280652, 3MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction ----
    GO:0010628positive regulation of gene expression IMP17223341
    GO:0016573histone acetylation IDA9267036

    NCOA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCOA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NCOA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    3 HMDB Compounds for NCOA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Vitamin D3(+)-Vitamin D3 (see all 32)67-97-0--

    10/22 Novoseek inferred chemical compound relationships for NCOA3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 78.8 136 11358796 (5), 18521745 (5), 16980945 (4), 11328819 (4) (see all 58)
    steroid 78.1 132 11358796 (3), 9488734 (2), 9765300 (2), 9252329 (2) (see all 86)
    4-hydroxytamoxifen 66.6 4 14673139 (1), 18827493 (1), 16670003 (1)
    tamoxifen 64 70 12618500 (7), 17332282 (6), 18827493 (5), 19628566 (5) (see all 18)
    progesterone 55.1 27 16775123 (2), 18521745 (2), 9765300 (1), 20392877 (1) (see all 19)
    retinoic acid 46.3 17 19144644 (3), 10598588 (1), 17663992 (1), 12573987 (1) (see all 9)
    retinoid 43.5 10 9488734 (1), 15137909 (1), 20190398 (1), 15001550 (1) (see all 6)
    estradiol 42.7 8 9774463 (1), 14766010 (1), 17276470 (1), 19095746 (1) (see all 7)
    testosterone 41.9 18 16921507 (4), 19659610 (1), 12750261 (1), 19463689 (1) (see all 8)
    glutamine 39.8 27 16434590 (4), 14648706 (4), 14684685 (3), 16365010 (2) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about NCOA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCOA3 gene (4 alternative transcripts): 
    NM_001174087.1  NM_001174088.1  NM_006534.3  NM_181659.2  

    Unigene Cluster for NCOA3:

    Nuclear receptor coactivator 3
    Hs.592142  [show with all ESTs]
    Unigene Representative Sequence: NM_181659
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372004 ENST00000371998 ENST00000371997 ENST00000490248 ENST00000497292
    ENST00000341724
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    Additional mRNA sequence: 

    AB209863.1 AF010227.1 AF012108.1 AF016031.1 AF036892.1 AK289683.1 AK296810.1 AK302588.1 
    AK302595.1 AK308346.1 BC036778.1 BC092516.1 BC119001.1 BC122547.1 

    19 DOTS entries:

    DT.75131632  DT.95276735  DT.100791387  DT.92434073  DT.100799076  DT.120798868  DT.95364754  DT.97781778 
    DT.100791391  DT.120798876  DT.120798928  DT.120798941  DT.120798973  DT.120799004  DT.91797572  DT.92434068 
    DT.97793395  DT.40234739  DT.91718596 

    24/299 AceView cDNA sequences (see all 299):

    AI571054 BQ643858 W17077 AA830096 AU135331 AA922415 AL599202 AA665470 
    BM772538 C05232 AA729022 AI146974 AI438999 AF012108 AW449795 AI697692 
    AW337430 AA905298 AA975377 AI927894 BU163982 AL707326 BM477753 AI581492 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA3 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NCOA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGACTTA
    NCOA3 Expression
    About this image


    See NCOA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA3

    SOURCE GeneReport for Unigene cluster: Hs.592142

    UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
    Tissue specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low
    expression in brain, and very low in lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA3 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa31 , 5 nuclear receptor coactivator 31, 5 84.09(n)1
    85.57(a)1
      2 (86.22 cM)5
    179791  NM_008679.31  NP_032705.21 
     1659926365 
    chicken
    (Gallus gallus)
    Aves NCOA31 nuclear receptor coactivator 3 75.04(n)
    77.86(a)
      419208  XM_417385.3  XP_417385.3 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA36
    Uncharacterized protein
    73(a)
    1 ↔ 1
    4(145286429-145320383)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980212 retinoid X receptor-interacting coactivator xSRC-3 75.24(n)    AF044080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncoa31 nuclear receptor coactivator 3 59.63(n)
    58.05(a)
      564519  XM_687846.5  XP_692938.5 


    ENSEMBL Gene Tree for NCOA3 (if available)
    TreeFam Gene Tree for NCOA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCOA3 gene
    NCOA12  NCOA22  
    2 SIMAP similar genes for NCOA3 using alignment to 4 protein entries:     NCOA3_HUMAN (see all proteins):
    NCOA2    NCOA1

    NCOA3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NCOA3
    PGOHUM00000249784


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
    Polymorphism: The length of the poly-Gln region is polymorphic in the normal population


    10/3534 SNPs in NCOA3 are shown (see all 3534)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0606974
    ----see VAR_0606972 M K mis40--------
    VAR_0606984
    ----see VAR_0606982 M L mis40--------
    VAR_0606954
    ----see VAR_0606952 R I mis40--------
    rs12068811,2
    C--42896115(-) ccccgC/Tccggc 4 -- int10--------
    rs716875251,2
    C--42902711(+) GTAAC-/AGTG  
            
    AGGCC
    4 -- int11Minor allele frequency- AGTG:0.00CSA 2
    rs30924801,2
    C--42902713(+) AACAG-/TGAG  
            
    GCCTT
    4 -- int10--------
    rs30917731,2
    C--42903618(+) TTTTT-/TCTTTT 4 -- int1 trp30--------
    rs30923171,2
    C--42911894(+) TTCTCTT/-CTCAT 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs2014158781,2
    --42914380(+) TTTTT-/TT    
       TTTTC
    CCTTA
    4 -- int10--------
    rs2001950841,2
    C--42914381(+) TTTTT-/TTTTTC
            
    CCTTA
    4 -- int10--------

    HapMap Linkage Disequilibrium report for NCOA3 (46130601 - 46285621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NCOA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509772CNV Insertion20534489
    esv33497CNV Loss17666407
    nsv527945CNV Loss19592680
    nsv833995CNV Loss17160897
    dgv100n6CNV Loss16902084
    nsv912908CNV Gain21882294
    nsv912907CNV Gain21882294
    dgv1333e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): NCOA3
    SABiosciences Cancer Mutation PCR Assays
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    Breast Cancer
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601937    OMIM disorders: --

    20/44 diseases for NCOA3 (see all 44):    About MalaCards
    megaesophagus    breast cancer    estrogen-receptor positive breast cancer    thyroiditis
    ovarian cancer    breast cancer susceptibility    synovial sarcoma    endometrial carcinoma
    teratocarcinoma    acute promyelocytic leukemia    encephalomyelitis    esophageal squamous cell carcinoma
    sarcoidosis    rhabdomyosarcoma    myeloid leukemia    chronic myeloid leukemia
    esophageal adenocarcinoma    thyroid cancer    pancreatic cancer    obesity


    NCOA3 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for NCOA3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 75.9 265 18827493 (5), 16670003 (5), 14503806 (5), 19102007 (5) (see all 99)
    ovarian cancer 46.2 19 18798508 (5), 16298470 (3), 17441340 (2), 9252329 (2) (see all 11)
    tumors 44.9 92 12618500 (5), 9865902 (4), 11678305 (4), 11103781 (4) (see all 49)
    mammary tumor 39.1 6 20051871 (2), 15380517 (2), 17145884 (1), 14747462 (1)
    cancer 36.5 46 16648476 (3), 17441340 (3), 16539836 (3), 20124470 (2) (see all 19)
    endometrial cancer 31.7 5 17532621 (3), 16980945 (1)
    prostate cancer 31.6 31 16140970 (6), 19305643 (3), 18260363 (2), 20086010 (2) (see all 10)
    breast carcinoma 22.2 7 19491275 (2), 11355743 (2), 11678305 (1), 11221879 (1)
    endometrial carcinoma 21.8 9 16980945 (5), 11355743 (3), 14751175 (1)
    endometrial hyperplasia 20.7 1 16980945 (1)

    Genetic Association Database (GAD): NCOA3
    Human Genome Epidemiology (HuGE) Navigator: NCOA3 (34 documents)

    Export disorders for NCOA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCOA3 gene, integrated from 9 sources (see all 434):
    (articles sorted by number of sources associating them with NCOA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PubMed id 9252329)1, 2, 3, 9 Anzick S.L.... Meltzer P.S. (1997)
    2. TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. (PubMed id 9346901)1, 2, 3 Takeshita A....Chin W.W. (1997)
    3. Association of NCOA3 polymorphisms with breast cancer risk. (PubMed id 15788663)1, 4, 9 Burwinkel B....Hemminki K. (2005)
    4. Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men. (PubMed id 16263829)1, 4, 9 Sheu Y.T....Ferrell R.E. (2006)
    5. The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (PubMed id 16244359)1, 4, 9 Colilla S....Rebbeck T.R. (2006)
    6. The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 16434590)1, 4, 9 Spurdle A.B.... . (2006)
    7. Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. (PubMed id 15900600)1, 4, 9 Hughes D.J....Sinilnikova O.M. (2005)
    8. AIB1 polymorphisms predict aggressive ovarian cancer phenotype. (PubMed id 16365010)1, 4, 9 Li A.J....Karlan B.Y. (2005)
    9. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (PubMed id 14557830)1, 4, 9 Wasserman L....Pierce J.P. (2004)
    10. Polymorphic repeat in AIB1 does not alter breast cancer risk. (PubMed id 11056690)1, 4, 9 Haiman C.A....Hunter D.J. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8202 HGNC: 7670 AceView: NCOA3 Ensembl:ENSG00000124151 euGenes: HUgn8202
    ECgene: NCOA3 H-InvDB: NCOA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ncoa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCOA3 gene:
    Search GeneIP for patents involving NCOA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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