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NCOA3 Gene

protein-coding   GIFtS: 71
GCID: GC20P046130

Nuclear Receptor Coactivator 3

  See NCOA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Coactivator 31 2     CBP-Interacting Protein2 3
Receptor-Associated Coactivator 31 2 3     pCIP2 3
Thyroid Hormone Receptor Activator Molecule 11 2 3     EC 2.3.1.483 8
AIB12 3 5     TNRC142 5
Amplified In Breast Cancer 1 Protein2 3     CAGH162
Class E Basic Helix-Loop-Helix Protein 422 3     CTG262
Steroid Receptor Coactivator Protein 32 3     KAT13B2
ACTR2 3     SRC32
AIB-12 3     TNRC162
RAC32 3     BHLHE423
SRC-32 3     NCoA-33
TRAM-12 3     RAC-33
bHLHe422 3     TRAM13

External Ids:    HGNC: 76701   Entrez Gene: 82022   Ensembl: ENSG000001241517   OMIM: 6019375   UniProtKB: Q9Y6Q93   

Export aliases for NCOA3 gene to outside databases

Previous GC identifers: GC20P045859 GC20P046769 GC20P046816 GC20P045564 GC20P042872


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCOA3 Gene:
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors
to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity
and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex.
This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation.
Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic
repeat region is found in the C-terminus of the encoded protein. (provided by RefSeq, Mar 2010)

GeneCards Summary for NCOA3 Gene:
NCOA3 (nuclear receptor coactivator 3) is a protein-coding gene. Diseases associated with NCOA3 include breast cancer. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is NCOA1.

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex,
which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors,
such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and
prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the
NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9

summary for NCOA3 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for NCOA3 (Nuclear receptor coactivator 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCOA3 gene promoter:
         AP-1   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCOA3 promoter sequence
   Search Chromatin IP Primers for NCOA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCOA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12

NCOA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P046130:  view genomic region     (about GC identifiers)

Start:
46,130,601 bp from pter      End:
46,285,621 bp from pter
Size:
155,021 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 3  
Size: 1424 amino acids; 155293 Da
Subunit: Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the
histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this
interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5
Miscellaneous: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers
3 PDB 3D structures from and Proteopedia for NCOA3:
1KBH (3D)        3L3X (3D)        3L3Z (3D)    
Secondary accessions: A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7
Alternative splicing: 5 isoforms:  Q9Y6Q9-1   Q9Y6Q9-2   Q9Y6Q9-3   Q9Y6Q9-4   Q9Y6Q9-5   

Explore the universe of human proteins at neXtProt for NCOA3: NX_Q9Y6Q9

Explore proteomics data for NCOA3 at MOPED

Post-translational modifications: 

  • Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors
    and regulates its function1
  • Methylated by CARM1 (By similarity)1
  • Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator
    function1
  • Ubiquitination2 at Lys316
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NCOA3 (Q9Y6Q9) (see all 9)
     EKRRREQE  IRRCIQRF  SHTFNCRML  MPQAPPQQF 


    See NCOA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001167558.1  NP_001167559.1  NP_006525.2  NP_858045.1  

    ENSEMBL proteins: 
     ENSP00000361073   ENSP00000361066   ENSP00000361065   ENSP00000342123  
    Reactome Protein details: Q9Y6Q9

    NCOA3 Human Recombinant Protein Products:

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    Novus Biologicals NCOA3 Protein
    Novus Biologicals NCOA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOA3

     
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    antibodies-online proteins for NCOA3 (2 products) 

     
    antibodies-online peptides for NCOA3

    NCOA3 Antibody Products:

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    antibodies-online antibodies for NCOA3 (108 products) 

    NCOA3 Assay Products:

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    Cloud-Clone Corp. ELISAs for NCOA3
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    antibodies-online kits for NCOA3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    bHLH: Basic helix-loop-helix proteins

    Selected InterPro protein domains (see all 10):
     IPR008955 Src1_rcpt_coact
     IPR010011 DUF1518
     IPR014935 SRC-1
     IPR014920 Nuc_rcpt_coact_Ncoa-typ
     IPR009110 Nuc_rcpt_coact

    Graphical View of Domain Structure for InterPro Entry Q9Y6Q9

    ProtoNet protein and cluster: Q9Y6Q9

    4 Blocks protein domains:
    IPB000014 PAS domain
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB010011 Protein of unknown function DUF1518
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
    Domain: Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with
    nuclear receptors, and constitute the RID domain (Receptor-interacting domain)
    Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Find genes that share domains with NCOA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA3_HUMAN, Q9Y6Q9
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex,
    which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors,
    such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and
    prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the
    NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
    Enzyme regulation: Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various
    hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn
    activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target
    genes by disrupting its association with nuclear receptors. Binds to CSNK1D

         Genatlas biochemistry entry for NCOA3:
    nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell lines,1,possessing an intrinsic
    histone acetyltransferase activity,interacting with CREBBP and PCAF,stimulating gene expression in a hormone
    dependent fashion,by facilitating the assembly of basal transcription factors into a stable preinitiation complex

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
    GO:0004402histone acetyltransferase activity IDA9267036
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI10866661
         
    Find genes that share ontologies with NCOA3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NCOA3:
     Increased cell number in G1, s  Synthetic lethal with imatinib  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ncoa3) (see all 20):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with NCOA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NCOA3: Ncoa3tm2.2Jxu Ncoa3tm1Rsd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCOA3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCOA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCOA3

    miRNA
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    miRTarBase miRNAs that target NCOA3:
    hsa-mir-192-5p (MIRT026651), hsa-mir-33a-5p (MIRT007358), hsa-mir-98-5p (MIRT004305), hsa-mir-335-5p (MIRT018366), hsa-mir-21-5p (MIRT004306), hsa-mir-18a-5p (MIRT004311), hsa-mir-17-5p (MIRT005408), hsa-mir-215-5p (MIRT024566), hsa-mir-744-5p (MIRT037458), hsa-mir-19b-3p (MIRT004310), hsa-mir-20a-5p (MIRT050588), hsa-mir-590-3p (MIRT016187), hsa-mir-29b-3p (MIRT004312)

    Block miRNA regulation of human, mouse, rat NCOA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCOA3 (see all 139):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-519a hsa-miR-3916 hsa-miR-1243 hsa-miR-3116 hsa-miR-200b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCOA3_HUMAN, Q9Y6Q9: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and
    subsequent phosphorylation, it translocates from the cytoplasm to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NCOA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCOA3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    Crosstalk Between CARM1 and ESRs0.39
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57


    Find genes that share SuperPaths with NCOA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NCOA3 (see all 6)
        AHR Pathway
    Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 Cell Signaling Technology (CST) Pathway for NCOA3
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for NCOA3
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle ESR1 regulation of G1/S transition
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 BioSystems Pathways for NCOA3
        Integrated Breast Cancer Pathway
    Androgen receptor signaling pathway
    FOXA1 transcription factor network
    Retinoic acid receptors-mediated signaling

    2 Reactome Pathways for NCOA3
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression

    1 PharmGKB Pathway for NCOA3
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NCOA3):
        Thyroid hormone signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA3 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCOA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCOA3 (Q9Y6Q91, 2, 3 ENSP000003610664) via UniProtKB, MINT, STRING, and/or I2D (see all 243)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000239836P280651, 2, 3, ENSP000003968134EBI-81196,EBI-603300 MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 STRING: ENSP00000396813
    PSMB9P280651, 2, 3, ENSP000003639934EBI-81196,EBI-603300 MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 STRING: ENSP00000363993
    ENSG00000240118P280651, 2, 3EBI-81196,EBI-603300 MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    ENSG00000240508P280651, 2, 3EBI-81196,EBI-603300 MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    ENSG00000242711P280651, 2, 3EBI-81196,EBI-603300 MINT-3291484 MINT-3291741 MINT-3291927 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----
    GO:0010628positive regulation of gene expression IMP17223341
    GO:0016573histone acetylation IDA9267036

    Find genes that share ontologies with NCOA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NCOA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    3 HMDB Compounds for NCOA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Vitamin D3(+)-Vitamin D3 (see all 32)67-97-0--

    Selected Novoseek inferred chemical compound relationships for NCOA3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 78.8 136 11358796 (5), 18521745 (5), 16980945 (4), 11328819 (4) (see all 58)
    steroid 78.1 132 11358796 (3), 9488734 (2), 9765300 (2), 9252329 (2) (see all 86)
    4-hydroxytamoxifen 66.6 4 14673139 (1), 18827493 (1), 16670003 (1)
    tamoxifen 64 70 12618500 (7), 17332282 (6), 18827493 (5), 19628566 (5) (see all 18)
    progesterone 55.1 27 16775123 (2), 18521745 (2), 9765300 (1), 20392877 (1) (see all 19)
    retinoic acid 46.3 17 19144644 (3), 10598588 (1), 17663992 (1), 12573987 (1) (see all 9)
    retinoid 43.5 10 9488734 (1), 15137909 (1), 20190398 (1), 15001550 (1) (see all 6)
    estradiol 42.7 8 9774463 (1), 14766010 (1), 17276470 (1), 19095746 (1) (see all 7)
    testosterone 41.9 18 16921507 (4), 19659610 (1), 12750261 (1), 19463689 (1) (see all 8)
    glutamine 39.8 27 16434590 (4), 14648706 (4), 14684685 (3), 16365010 (2) (see all 13)



    Find genes that share compounds with NCOA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCOA3 gene (4 alternative transcripts): 
    NM_001174087.1  NM_001174088.1  NM_006534.3  NM_181659.2  

    Unigene Cluster for NCOA3:

    Nuclear receptor coactivator 3
    Hs.592142  [show with all ESTs]
    Unigene Representative Sequence: NM_181659
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372004 ENST00000371998 ENST00000371997 ENST00000490248 ENST00000497292
    ENST00000341724
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCOA3 (see all 139):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-519a hsa-miR-3916 hsa-miR-1243 hsa-miR-3116 hsa-miR-200b
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    eBioscience FlowRNA Probe Sets ( VA1-10453) for NCOA3 

    Additional mRNA sequence: 

    AB209863.1 AF010227.1 AF012108.1 AF016031.1 AF036892.1 AK289683.1 AK296810.1 AK302588.1 
    AK302595.1 AK308346.1 BC036778.1 BC092516.1 BC119001.1 BC122547.1 

    19 DOTS entries:

    DT.75131632  DT.95276735  DT.100791387  DT.92434073  DT.100799076  DT.120798868  DT.95364754  DT.97781778 
    DT.100791391  DT.120798876  DT.120798928  DT.120798941  DT.120798973  DT.120799004  DT.91797572  DT.92434068 
    DT.97793395  DT.40234739  DT.91718596 

    Selected AceView cDNA sequences (see all 299):

    BU677059 AI433009 R62184 AI565219 AL698932 BU852343 AF012108 BQ643858 
    BM756630 AI270423 AA678419 AW449795 AW589329 AA905298 AI220501 BQ653563 
    BQ232932 AI697692 AI471698 BM464911 AL709631 BX094220 BQ424449 BM772538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCOA3 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NCOA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCOA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGACTTA
    NCOA3 Expression
    About this image


    NCOA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NCOA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCOA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592142

    UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
    Tissue specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low
    expression in brain, and very low in lung, liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA3 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa31 , 5 nuclear receptor coactivator 31, 5 83.85(n)1
    85.28(a)1
      2 (86.22 cM)5
    179791  NM_008679.31  NP_032705.21 
     1659926365 
    chicken
    (Gallus gallus)
    Aves NCOA31 nuclear receptor coactivator 3 74.62(n)
    77.35(a)
      419208  XM_004947056.1  XP_004947113.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA36
    nuclear receptor coactivator 3
    74(a)
    1 ↔ 1
    4(145286429-145320383)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980212 retinoid X receptor-interacting coactivator xSRC-3 75.24(n)    AF044080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncoa31 nuclear receptor coactivator 3 59.93(n)
    58.52(a)
      564519  XM_687846.6  XP_692938.5 


    ENSEMBL Gene Tree for NCOA3 (if available)
    TreeFam Gene Tree for NCOA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCOA3 gene
    NCOA12  NCOA22  
    2 SIMAP similar genes for NCOA3 using alignment to 4 protein entries:     NCOA3_HUMAN (see all proteins):
    NCOA2    NCOA1

    Find genes that share paralogs with NCOA3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NCOA3
    PGOHUM00000249784


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NCOA3_HUMAN, Q9Y6Q9: The length of the poly-Gln region is polymorphic in the normal population


    Selected SNPs for NCOA3 (see all 3534)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12068811,2
    C--42896115(-) ccccgC/Tccggc 4 -- int10--------
    rs716875251,2
    C--42902711(+) GTAAC-/AGTG  
            
    AGGCC
    4 -- int11Minor allele frequency- AGTG:0.00CSA 2
    rs30924801,2
    C--42902713(+) AACAG-/TGAG  
            
    GCCTT
    4 -- int10--------
    rs30917731,2
    C--42903618(+) TTTTT-/TCTTTT 4 -- int1 trp30--------
    rs30923171,2
    C--42911894(+) TTCTCTT/-CTCAT 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs2014158781,2
    --42914380(+) TTTTT-/TT    
       TTTTC
    CCTTA
    4 -- int10--------
    rs2001950841,2
    C--42914381(+) TTTTT-/TTTTTC
            
    CCTTA
    4 -- int10--------
    rs680953251,2
    --42914386(+) TTTTTT/CCCTTA 4 -- int11Minor allele frequency- C:0.00CSA 1
    rs1135768151,2
    C--42915184(+) GTAGCT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs114079211,2
    C--42922978(+) TTTTT-/TAAGAC 4 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for NCOA3 (46130601 - 46285621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NCOA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509772CNV Insertion20534489
    esv33497CNV Loss17666407
    nsv527945CNV Loss19592680
    nsv833995CNV Loss17160897
    dgv100n6CNV Loss16902084
    nsv912908CNV Gain21882294
    nsv912907CNV Gain21882294
    dgv1333e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NCOA3
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing NCOA3:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing NCOA3
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601937    OMIM disorders: --

    1 disease for NCOA3:    
    About MalaCards
    breast cancer


    Find genes that share disorders with NCOA3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NCOA3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 75.9 265 18827493 (5), 16670003 (5), 14503806 (5), 19102007 (5) (see all 99)
    ovarian cancer 46.2 19 18798508 (5), 16298470 (3), 17441340 (2), 9252329 (2) (see all 11)
    tumors 44.9 92 12618500 (5), 9865902 (4), 11678305 (4), 11103781 (4) (see all 49)
    mammary tumor 39.1 6 20051871 (2), 15380517 (2), 17145884 (1), 14747462 (1)
    cancer 36.5 46 16648476 (3), 17441340 (3), 16539836 (3), 20124470 (2) (see all 19)
    endometrial cancer 31.7 5 17532621 (3), 16980945 (1)
    prostate cancer 31.6 31 16140970 (6), 19305643 (3), 18260363 (2), 20086010 (2) (see all 10)
    breast carcinoma 22.2 7 19491275 (2), 11355743 (2), 11678305 (1), 11221879 (1)
    endometrial carcinoma 21.8 9 16980945 (5), 11355743 (3), 14751175 (1)
    endometrial hyperplasia 20.7 1 16980945 (1)

    Genetic Association Database (GAD): NCOA3
    Human Genome Epidemiology (HuGE) Navigator: NCOA3 (34 documents)

    Export disorders for NCOA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCOA3 gene, integrated from 10 sources (see all 439):
    (articles sorted by number of sources associating them with NCOA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PubMed id 9252329)1, 2, 3, 9 Anzick S.L.... Meltzer P.S. (Science 1997)
    2. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. (PubMed id 9346901)1, 2, 3 Takeshita A.... Chin W.W. (J. Biol. Chem. 1997)
    3. Association of NCOA3 polymorphisms with breast cancer risk. (PubMed id 15788663)1, 4, 9 Burwinkel B....Hemminki K. (Clin. Cancer Res. 2005)
    4. Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men. (PubMed id 16263829)1, 4, 9 Sheu Y.T....Ferrell R.E. (J. Clin. Endocrinol. Metab. 2006)
    5. The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (PubMed id 16244359)1, 4, 9 Colilla S....Rebbeck T.R. (Carcinogenesis 2006)
    6. The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 16434590)1, 4, 9 Spurdle A.B.... . (amp 2006)
    7. Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. (PubMed id 15900600)1, 4, 9 Hughes D.J....Sinilnikova O.M. (Int. J. Cancer 2005)
    8. AIB1 polymorphisms predict aggressive ovarian cancer phenotype. (PubMed id 16365010)1, 4, 9 Li A.J....Karlan B.Y. (amp 2005)
    9. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (PubMed id 14557830)1, 4, 9 Wasserman L....Pierce J.P. (Int. J. Obes. Relat. Metab. Disord. 2004)
    10. Polymorphic repeat in AIB1 does not alter breast cancer risk. (PubMed id 11056690)1, 4, 9 Haiman C.A....Hunter D.J. (Breast Cancer Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8202 HGNC: 7670 AceView: NCOA3 Ensembl:ENSG00000124151 euGenes: HUgn8202
    ECgene: NCOA3 Kegg: 8202 H-InvDB: NCOA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCOA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ncoa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCOA3 gene:
    Search GeneIP for patents involving NCOA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCOA3
     LSBio Antibodies in human, mouse, rat for NCOA3
     Browse compounds at ApexBio
     Search Addgene for plasmids for NCOA3
      Search eBioscience for proteins for NCOA3
      Search eBioscience for elisas for NCOA3
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
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     Tissue-specific gene expresssion
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     antibodies-online antibodies for NCOA3 (108 products)
     antibodies-online kits for NCOA3 (8 products)
     antibodies-online peptides for NCOA3
     antibodies-online proteins for NCOA3 (2 products)
           
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