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NCOA3 Gene

protein-coding GIFtS: 66

GC20P045564

nuclear receptor coactivator 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTR ^¹, ², ³
AIB-1 ^², ³
AIB1 ^¹, ², ³, ⁵
CAGH16 ^¹, ²
CTG26 ^²
EC 2.3.1.48 ^³
KAT13B ^¹, ²
MGC141848 ^²
NCoA-3 ^³
OTTHUMP00000031716 ^²
OTTHUMP00000031718 ^²
RAC-3 ^³
RAC3 ^¹, ², ³
SRC-3 ^¹, ², ³
SRC3 ^¹, ²
TNRC14 ^², ⁵
TNRC16 ^¹, ²
TRAM-1 ^¹, ², ³
TRAM1 ^³
bHLHe42 ^¹, ²
p/CIP ^¹
pCIP ^², ³

Descriptions
Amplified in breast cancer-1 protein ^³
CBP-interacting protein ^², ³
Receptor-associated coactivator 3 ^², ³
Steroid receptor coactivator protein 3 ^², ³
Thyroid hormone receptor activator molecule 1 ^², ³
amplified in breast cancer-1 ^²
nuclear receptor coactivator 3 ^²

External Ids
HGNC: 7670¹
Entrez Gene: 8202²
UniProtKB: Q9Y6Q9³
Ensembl: ENSG00000124151⁷

Search outside databases for aliases for NCOA3 gene

Previous GC identifers: GC20P045859 GC20P046769 GC20P046816

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NCOA3:

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear

hormone receptors to enhance their transcriptional activator functions. The encoded protein has

histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding

protein as part of a multisubunit coactivation complex. This protein is initially found in the

cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants

encoding different isoforms have been found for this gene. In addition, a polymorphic repeat

region is found in the C-terminus of the encoded protein. [provided by RefSeq]

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9

Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the

transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a

multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the

coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and

RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone

acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its

interaction with the NFKB1 subunit

Gene Wiki entry for NCOA3 (Nuclear_receptor_coactivator_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NCOA3 gene

Entrez Gene cytogenetic band: 20q12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12

NCOA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P045564: (about GC identifiers)

Start:	45,564,053 bp from pter
End:	45,719,023 bp from pter
Size:	154,971 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9 (See protein sequence)

Recommended Name: Nuclear receptor coactivator 3

Size: 1424 amino acids; 155293 Da

Subunit: Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB,

IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF.

Interacts with ATAD2 and this interaction is enhanced by estradiol

Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF

activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus

Miscellaneous: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers

PDB structures from and Proteopedia :

1KBH (3D)

Secondary accessions: Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7

Alternative splicing: 5 isoforms: Q9Y6Q9-1 Q9Y6Q9-2 Q9Y6Q9-3 Q9Y6Q9-4 Q9Y6Q9-5 (Additional isoforms seem to exist)

Post-translational modifications:

Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with

nuclear receptors and regulates its function¹

Methylated by CARM1 (By similarity)¹

Phosphorylated by IKK complex. Regulated its function¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_006525.2 NP_858045.1

ENSEMBL proteins:

ENSP00000361065 ENSP00000361073 ENSP00000342123 ENSP00000361066 ENSP00000345671

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KAT13B / AIB1)
	Human Recombinant Proteins from Abnova (NCOA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for NCOA3:

	Invitrogen Antibodies for NCOA3
	Millipore Mono- and Polyclonal Antibodies for the study of NCOA3
	Sigma-Aldrich Antibodies for NCOA3
	R&D Systems Antibodies for NCOA3
	Cell Signaling Technology (CST) Antibodies for NCOA3 (SRC-3)
	Antibodies from Abcam (KAT13B / AIB1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NCOA3)
	Novus Biologicals Antibodies for NCOA3

Assays for NCOA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y6Q9

ProtoNet protein and cluster: Q9Y6Q9

4 Blocks protein families:

IPB000014 PAS domain

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB010011 Protein of unknown function DUF1518

IPB013767 PAS fold

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9

Domain: Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the

association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain)

Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCOA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006534

Applied Biosystems Silencer® siRNAs for NCOA3

Sigma-Aldrich siRNA for NCOA3

Sigma-Aldrich shRNA for NCOA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006534
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006534
untagged cDNA clones in CMV expression vector (see all 3): NM_006534

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181659

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9

Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the

transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a

multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the

coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and

RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone

acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its

interaction with the NFKB1 subunit

Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone

Enzyme regulation: Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by

various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances

phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP

apparently suppresses coactivation of target genes by disrupting its association with nuclear

receptors

Enzyme Number (IUBMB): EC 2.3.1.48

Genatlas biochemistry entry for NCOA3:

nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell

lines,1,possessing an intrinsic histone acetyltransferase activity,interacting with CREBBP and

PCAF,stimulating gene expression in a hormone dependent fashion,by facilitating the assembly of

basal transcription factors into a stable preinitiation complex

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ncoa3):

cellular	craniofacial	embryogenesis	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal	reproductive system	skin/coat/nails

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	NAS	9267036 15572661
GO:0004402	histone acetyltransferase activity	TAS	--
GO:0004871	signal transducer activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for NCOA3 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Glucocorticoid Receptor Signaling
TR/RXR Activation
Aryl Hydrocarbon Receptor Signaling
VDR/RXR Activation
Estrogen Receptor Signaling

GeneDecks NCOA3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NCOA3

5/18 Interacting proteins for NCOA3 (Q9Y6Q9^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 18 )
Interactant Interaction Details
GeneCard External ID(s)
CHUK O15111¹ EBI-81196, EBI-81249
EP300 Q09472¹ EBI-81196, EBI-447295
ESR1 P03372¹ EBI-81196, EBI-78473
IKBKB O14920¹ EBI-81196, EBI-81266
IKBKG Q9Y6K9¹ EBI-81196, EBI-81279
About this table
3 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0045893 positive regulation of transcription, DNA-dependent NAS 15572661
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NCOA3
6 Novoseek chemical compound relationships for NCOA3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	77.39	119	11358796 (3), 9488734 (2), 9765300 (2), 9252329 (2) (see all 75)
progesterone	54.84	25	16775123 (2), 18521745 (2), 9765300 (1), 9865902 (1) (see all 17)
estradiol	43.36	8	9774463 (1), 14766010 (1), 17276470 (1), 19095746 (1) (see all 7)
bromodeoxyuridine	0.00	1	16140970 (1)
tyrosine	0.00	8	17671194 (2), 14747462 (1), 15199112 (1)
phosphatidylinositol	0.00	1	17145884 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCOA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCOA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006534

Sigma-Aldrich siRNA for NCOA3

Sigma-Aldrich shRNA for NCOA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006534 NM_181659

REFSEQ mRNAs for NCOA3 gene (2 alternative transcripts):

NM_006534.2 NM_181659.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006534 NM_181659

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006534
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006534
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006534

Additional cDNA sequence:

AB209863.1 AF010227.1 AF012108.1 AF016031.1 AF036892.1 AK289683.1 AK296810.1 AK302588.1

AK302595.1 AK308346.1 BC036778.1 BC092516.1 BC119001.1 BC122547.1

19 DOTS entries:

DT.75131632 DT.95276735 DT.100791387 DT.92434073 DT.120798868 DT.95364754 DT.97781778 DT.100799076

DT.100791391 DT.120798876 DT.120798928 DT.120798941 DT.120798973 DT.120799004 DT.91797572 DT.92434068

DT.97793395 DT.40234739 DT.91718596

24/299 AceView cDNA sequences (see all 299 ):

W77872 AA830096 AI921560 R28559 AL698932 BQ437320 AW589329 AA346493

AA665470 BM464911 AF012108 AW080461 BQ643858 AI565219 AI433009 AI697692

AU155977 AI220501 C05232 BQ653563 AW449795 BQ232932 BQ008205 AI438999

highest scoring ESTs for NCOA3:

AF012108 AI761748 AA045313 AA065268 AA065269 AA156793 AA156882 AA173446 AA174163 AA230072

Unigene Cluster for NCOA3:

Nuclear receptor coactivator 3

Hs.592142 [show with all ESTs]

Unigene Representative Sequence: NM_181659

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA3 (see all 15 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·
SP1:
SP2:
SP3:																					-
SP4:
SP5:

ExUns:	18c	^	19a	·	19b	^	20	^	21	^	22a	·	22b	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NCOA3

5 Ensembl transcripts including schematic representations:

ENST00000371997 ENST00000372004 ENST00000341724 ENST00000371998 ENST00000340189

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NCOA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NCOA3

¹ / ² / ³

13 probe-sets matching NCOA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50379_at²^{, 3}	U95-B	1	1.00	1.00	0.95	1.25	AI761748	1.00	1.00	1.00	1
33381_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.75	AF012108	1.00	1.00	1.00	1
207700_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006534	0.60	1.00	0.82	1
209061_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI761748	1.00	1.00	1.00	1
211352_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U80737	0.20	1.00	0.72	1
209062_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF010227	0.80	1.00	0.91	1
209060_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI438999	0.80	1.00	0.91	1
207700_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209061_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211352_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209062_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209060_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1562439_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATGACTTA

SOURCE GeneReport for Unigene cluster: Hs.592142
Expression variation in blood from EXPOLDB for NCOA3
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9
Tissue specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and
placenta. Low expression in brain, and very low in lung, liver and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NCOA3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NCOA3¹	--	nuclear receptor coactivator 3	91.2(n) 92.83(a)	485915 XM_543039.2 XP_543039.2
cow (Bos taurus)	NCOA3¹	--	nuclear receptor coactivator 3	89.46(n) 91.17(a)	523707 XM_602010.3 XP_602010.3
rat (Rattus norvegicus)	Ncoa3¹	--	nuclear receptor coactivator 3	84.32(n) 85.31(a)	84584 XM_215947.4 XP_215947.4
mouse (Mus musculus)	Ncoa3^{1, 5}	2⁵	nuclear receptor coactivator 3^{1, 5}	84.07(n)¹ 85.5(a)¹	17979¹ NM_008679.2¹ NP_032705.2¹ AA462879⁵ AF000581⁵ (see all 21)
chicken (Gallus gallus)	NCOA3¹	--	nuclear receptor coactivator 3	74.91(n) 77.57(a)	419208 XM_417385.2 XP_417385.2

About this table Species with no ortholog for NCOA3

ENSEMBL Gene Tree for NCOA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NCOA3 gene

NCOA1² NCOA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9

Polymorphism: The length of the poly-Gln region is polymorphic in the normal population

10/1296 NCBI SNPs in NCOA3 are shown (see all 1296 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 309)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs14189^1,2	A,C,F,H	45717801(+)	`AGAGGA/TAGAAC`	2	--	ut3¹ ese³ trp³		8	MN EU EA WA NA	722
	rs12273^1,2	A,C,F,H	45717809(+)	`AACCAG/AGTCAG`	2	--	ut3¹		8	MN EU EA WA NA	740
	rs2230782^1,2	C,F,H,O	45698295(+)	`TGTCAG/CTCAAA`	2	H/Q	mis¹		12	MN EU EA WA NA	1020
	rs11699879^1,2	A,C,F,H	45716790(+)	`AATCTA/GAATGC`	2	--	ut3¹		11	NA EU EA WA	954
--	rs3092417^1,2	C,F,H	45715753(+)	`TATCTA/GCGTGT`	2	--	ut3¹ ese³		7	EU EA WA NA	556
	rs2230781^1,2	C,F,H	45698212(+)	`CCCAAC/TCAAGT`	2	P/S	mis¹		9	MN EU EA WA	880
	rs6094752^1,2	C,F,H	45689831(+)	`AAATGC/TGCCAG`	2	R/C	mis¹ ese³		8	EU EA WA	838
	rs1332495^1,2	C,F,H	45564073(+)	`acggcG/Agcggc`	2	--	ut5¹ ese³		8	MN EU EA WA NA	742
	rs11699902^1,2	C,F,H	45716994(+)	`AATTCA/GTGGGC`	2	--	ut3¹		4	EU EA WA	420
	rs2179591^1,2	A,F,H	45717991(+)	`GCAGCG/ACTCCC`	2	--	ut3¹		3	EA WA	292

About this table

HapMap Linkage Disequilibrium images for NCOA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601937

10/28 Novoseek disease relationships for NCOA3 gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	74.73	226	18827493 (5), 16670003 (5), 14503806 (5), 19102007 (5) (see all 85)
ovarian cancer	45.72	18	18798508 (5), 16298470 (3), 17441340 (2), 9252329 (2) (see all 10)
tumors	44.68	90	12618500 (5), 9865902 (4), 11678305 (4), 11103781 (4) (see all 47)
mammary tumor	37.08	4	15380517 (2), 17145884 (1), 14747462 (1)
cancer	35.76	35	16648476 (3), 17441340 (3), 16539836 (3), 16140970 (2) (see all 16)
endometrial cancer	34.60	5	17532621 (3), 16980945 (1)
prostate cancer	28.76	21	16140970 (6), 19305643 (3), 18260363 (2), 14871982 (1) (see all 9)
endometrial carcinoma	24.52	9	16980945 (5), 11355743 (3), 14751175 (1)
endometrial hyperplasia	23.28	1	16980945 (1)
epithelial tumor	22.79	3	17671194 (1), 16951183 (1), 15448000 (1)

About this table

Human Gene Mutation Database: NCOA3
Genetic Association Database: NCOA3
Human Genome Epidemiology Navigator: NCOA3 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/291 PubMed articles for NCOA3 gene (see all 291 ):

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PubMed id 9252329)^{1, 2, 3, 4} Anzick S.L.... Meltzer P.S. (1997)
TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. (PubMed id 9346901)^{2, 3, 4} Takeshita A....Chin W.W. (1997)
Association of NCOA3 polymorphisms with breast cancer risk. (PubMed id 15788663)^{1, 3, 6} Burwinkel B....Hemminki K. (2005)
The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (PubMed id 16244359)^{1, 3, 6} Colilla S....Rebbeck T.R. (2006)
Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. (PubMed id 15900600)^{1, 3, 6} Hughes D.J....Sinilnikova O.M. (2005)
AIB1 polymorphisms predict aggressive ovarian cancer phenotype. (PubMed id 16365010)^{1, 3, 6} Li A.J....Karlan B.Y. (2005)
Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (PubMed id 14557830)^{1, 3, 6} Wasserman L....Pierce J.P. (2004)
Polymorphic repeat in AIB1 does not alter breast cancer risk. (PubMed id 11056690)^{1, 3, 6} Haiman C.A....Hunter D.J. (2000)
Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer-1 (AIB1), are associated with quantitative calcaneal ultrasound. (PubMed id 11092404)^{1, 3, 6} Patel M.S....Rubin L.A. (2000)
Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk. (PubMed id 11161840)^{1, 3, 6} Jernstrom H....Narod S.A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8202	HGNC: 7670	AceView: NCOA3	Ensembl:ENSG00000124151	euGenes: HUgn8202
ECgene: NCOA3	H-InvDB: NCOA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NCOA3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NCOA3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NCOA3:

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Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NCOA3-related products

	Millipore Custom Antibody & Bulk Services
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	Recombinant Proteins (KAT13B / AIB1)
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Antibodies for NCOA3

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NCOA3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for NCOA3

Summaries
for NCOA3

Genomic Location
for NCOA3

Proteins
for NCOA3

Protein Domains/
Families
for NCOA3

Gene Function
for NCOA3

Pathways & Interactions
for NCOA3

Drugs & Compounds
for NCOA3

Transcripts
for NCOA3

Expression
for NCOA3

Orthologs
for NCOA3

Paralogs
for NCOA3

SNPs/Variants
for NCOA3

Disorders & Mutations
for NCOA3

Medical News
for NCOA3

Publications
for NCOA3

Search for NCOA3

Genome Databases showing NCOA3

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Specialized Databases showing NCOA3

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for NCOA3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NCOA3 (Gene Symbol)
ACTR
AIB-1
AIB1
CAGH16
CTG26
EC 2.3.1.48
KAT13B
MGC141848
NCoA-3
OTTHUMP00000031716
OTTHUMP00000031718
RAC-3
RAC3
SRC-3
SRC3
TNRC14
TNRC16
TRAM-1
TRAM1
bHLHe42
p/CIP
pCIP
Amplified in breast cancer-1 protein
CBP-interacting protein
Receptor-associated coactivator 3
Steroid receptor coactivator protein 3
Thyroid hormone receptor activator molecule 1
amplified in breast cancer-1
nuclear receptor coactivator 3

NCOA3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor NCOA3

Summariesfor NCOA3

Genomic Locationfor NCOA3

Proteinsfor NCOA3

Protein Domains/Familiesfor NCOA3

Gene Functionfor NCOA3

Pathways & Interactionsfor NCOA3

Drugs & Compoundsfor NCOA3

Transcriptsfor NCOA3

Expression for NCOA3

Orthologsfor NCOA3

Paralogsfor NCOA3

SNPs/Variantsfor NCOA3

Disorders & Mutationsfor NCOA3

Medical Newsfor NCOA3

Publicationsfor NCOA3

Search for NCOA3

Genome Databases showing NCOA3

Other Databases showing NCOA3

Specialized Databases showing NCOA3

Licensable Technologiesfor NCOA3

Servicesfor NCOA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NCOA3

Summaries
for NCOA3

Genomic Location
for NCOA3

Proteins
for NCOA3

Protein Domains/
Families
for NCOA3

Gene Function
for NCOA3

Pathways & Interactions
for NCOA3

Drugs & Compounds
for NCOA3

Transcripts
for NCOA3

Expression
for NCOA3

Orthologs
for NCOA3

Paralogs
for NCOA3

SNPs/Variants
for NCOA3

Disorders & Mutations
for NCOA3

Medical News
for NCOA3

Publications
for NCOA3

Licensable Technologies
for NCOA3

Services
for NCOA3