NCOA3 Gene
protein-coding GIFtS: 70
GCID: GC20P046130
|
|
nuclear receptor coactivator 3
| |
Aliases
for NCOA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Coactivator 31 2 | | Steroid Receptor Coactivator Protein 32 3 | | AIB11 2 3 5 | | Thyroid Hormone Receptor Activator Molecule 12 3 | | ACTR1 2 3 | | AIB-12 3 | | RAC31 2 3 | | CBP-Interacting Protein2 3 | | SRC-31 2 3 | | PCIP1 | | TRAM-11 2 3 | | EC 2.3.1.483 8 | | BHLHe421 | | TNRC142 5 | | CAGH161 2 | | P/CIP1 | | KAT13B1 2 | | CTG262 | | SRC31 2 | | BHLHE423 | | TNRC161 2 | | NCoA-33 | | Amplified In Breast Cancer 1 Protein2 3 | | RAC-33 | | Class E Basic Helix-Loop-Helix Protein 422 3 | | TRAM13 | | Receptor-Associated Coactivator 32 3 | | |
Export aliases for NCOA3 gene to outside databasesPrevious GC identifers: GC20P045859 GC20P046769 GC20P046816 GC20P045564 GC20P042872 |
Summaries
for NCOA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCOA3:
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors toenhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity andrecruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. Thisprotein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Severaltranscript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeatregion is found in the C-terminus of the encoded protein. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptionalactivities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, whichprobably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as forsteroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via itsinteraction with the NFKB1 subunit. Interacts with PSMB9
 summary
for NCOA3: Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.
Gene Wiki entry for NCOA3 (Nuclear receptor coactivator 3)
|
Genomic Views
for NCOA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCOA3 gene promoter:
AP-1 MyoD GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCOA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12NCOA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P046130: view genomic region
(about GC identifiers)
Start:
|
46,130,601 bp from pter |
End:
|
46,285,621 bp from pter |
Size:
|
155,021 bases |
Orientation:
|
plus strand |
|
Proteins
for NCOA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9 (See
protein sequence)Recommended Name: Nuclear receptor coactivator 3 Size: 1424 amino acids; 155293 Da
Subunit: Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histoneacetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interactionis enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5
Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation andsubsequent phosphorylation, it translocates from the cytoplasm to the nucleus
Miscellaneous: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers
3 PDB 3D structures from  and Proteopedia  for NCOA3:1KBH (3D)
3L3X (3D)
3L3Z (3D)
Secondary accessions: A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7Alternative splicing: 5 isoforms: Q9Y6Q9-1 Q9Y6Q9-2 Q9Y6Q9-3 Q9Y6Q9-4 Q9Y6Q9-5 Explore the universe of human proteins at neXtProt for NCOA3: NX_Q9Y6Q9
Post-translational modifications:
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors andregulates its function1
Methylated by CARM1 (By similarity)1
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6Q9
4/9 DME Specific Peptides for NCOA3 (Q9Y6Q9) (see all 9)
NCOA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001167558.1 NP_001167559.1 NP_006525.2 NP_858045.1
ENSEMBL proteins: ENSP00000361073 ENSP00000361066 ENSP00000361065 ENSP00000345671 ENSP00000342123 Reactome Protein details: Q9Y6Q9
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NCOA3 for ontologies About GeneDecksing
NCOA3 Antibody Products:
Assay Products for NCOA3: |
Protein
Domains /
Families
for NCOA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCOA3 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9Y6Q9ProtoNet protein and cluster: Q9Y6Q9 4 Blocks protein families: IPB000014 PAS domain IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB010011 Protein of unknown function DUF1518 IPB013767 PAS fold
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9Domain: Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association withnuclear receptors, and constitute the RID domain (Receptor-interacting domain)Similarity: Belongs to the SRC/p160 nuclear receptor coactivator familySimilarity: Contains 1 bHLH (basic helix-loop-helix) domainSimilarity: Contains 1 PAS (PER-ARNT-SIM) domain |
Function
for NCOA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptionalactivities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, whichprobably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as forsteroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via itsinteraction with the NFKB1 subunit. Interacts with PSMB9Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]Enzyme regulation: Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones,and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activatescoactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes bydisrupting its association with nuclear receptors. Binds to CSNK1D Genatlas biochemistry entry for NCOA3:nuclear receptor coactivator 3,amplified gene in breast cancer and pancreatic cell lines,1,possessing an intrinsichistone acetyltransferase activity,interacting with CREBBP and PCAF,stimulating gene expression in a hormone dependentfashion,by facilitating the assembly of basal transcription factors into a stable preinitiation complex
Enzyme Number (IUBMB): EC 2.3.1.481 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): NCOA3 (NM_006534) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA3 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
NCOA3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for NCOA3:
Animal Models:
Mouse knock-outs for NCOA3: Ncoa3tm2.2Jxu Ncoa3tm1Rsd
15/20 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ncoa3) (see all 20):
NCOA3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NCOA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_Ligand-independent activation of ESR1 and ESR2 | | | 2 | Cell cycle ESR1 regulation of G1/S transition | | | 3 | Assembly of RNA Polymerase-II Initiation Complex | | | 4 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 5 | HIV Infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for NCOA3
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOA3 (see all 6)
1 
Cell Signaling Technology (CST) Pathway for NCOA3
4  GeneGo (Thomson Reuters) Pathways for NCOA3
4  BioSystems Pathways for NCOA3
2 
Reactome Pathways for NCOA3
1  PharmGKB Pathway for NCOA3
NCOA3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/214 Interacting proteins for NCOA3 (Q9Y6Q91, 2, 3 ENSP000003610664) via UniProtKB, MINT, STRING, and/or I2D (see all 214)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
NCOA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCOA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCOA3 for compounds About GeneDecksing
Compounds for NCOA3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| EHT 1864 | Potent inhibitor of Rac family GTPases | -- |
3 HMDB Compounds for NCOA3 About this table
10/22 Novoseek chemical compound relationships for NCOA3 gene (see all 22) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrogen |
78.8 |
136 |
11358796 (5), 18521745 (5), 16980945 (4), 11328819 (4) (see all 58) |
| steroid |
78.1 |
132 |
11358796 (3), 9488734 (2), 9765300 (2), 9252329 (2) (see all 86) |
| 4-hydroxytamoxifen |
66.6 |
4 |
14673139 (1), 18827493 (1), 16670003 (1) |
| tamoxifen |
64 |
70 |
12618500 (7), 17332282 (6), 18827493 (5), 19628566 (5) (see all 18) |
| progesterone |
55.1 |
27 |
16775123 (2), 18521745 (2), 9765300 (1), 20392877 (1) (see all 19) |
| retinoic acid |
46.3 |
17 |
19144644 (3), 10598588 (1), 17663992 (1), 12573987 (1) (see all 9) |
| retinoid |
43.5 |
10 |
9488734 (1), 15137909 (1), 20190398 (1), 15001550 (1) (see all 6) |
| estradiol |
42.7 |
8 |
9774463 (1), 14766010 (1), 17276470 (1), 19095746 (1) (see all 7) |
| testosterone |
41.9 |
18 |
16921507 (4), 19659610 (1), 12750261 (1), 19463689 (1) (see all 8) |
| glutamine |
39.8 |
27 |
16434590 (4), 14648706 (4), 14684685 (3), 16365010 (2) (see all 13) |
Search CenterWatch for drugs/clinical trials and news about NCOA3
|
Transcripts
for NCOA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCOA3 gene (4 alternative transcripts): NM_001174087.1 NM_001174088.1 NM_006534.3 NM_181659.2 Unigene Cluster for NCOA3: Nuclear receptor coactivator 3 Hs.592142 [show with all ESTs]Unigene Representative Sequence: NM_1816597 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372004 ENST00000371998 ENST00000371997 ENST00000490248 ENST00000497292
ENST00000340189(uc002xtk.3 uc002xtl.3 uc002xtn.3 uc010ght.2 uc002xtm.3 uc010zyc.2)
ENST00000341724
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): NCOA3 (NM_006534) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA3 |
Additional cDNA sequence: AB209863.1 AF010227.1 AF012108.1 AF016031.1 AF036892.1 AK289683.1 AK296810.1 AK302588.1 AK302595.1 AK308346.1 BC036778.1 BC092516.1 BC119001.1 BC122547.1 19 DOTS entries: DT.75131632 DT.95276735 DT.100791387 DT.92434073 DT.100799076 DT.120798868 DT.95364754 DT.97781778 DT.100791391 DT.120798876 DT.120798928 DT.120798941 DT.120798973 DT.120799004 DT.91797572 DT.92434068 DT.97793395 DT.40234739 DT.91718596 24/299 AceView cDNA sequences (see all 299): AI817332 BM772538 AW337430 BP352922 CA450268 AL599202 AA975377 BQ694192 BQ424449 BU685837 AW589329 BX094220 AA830096 AI571054 BQ232932 AA678419 BU677059 AI697692 AW449795 AL698932 AF012108 AA922415 AI220501 R28559
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA3 (see all 15) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCOA3
|
Expression
for NCOA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCOA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGACTTA
About this image
See NCOA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCOA3
SOURCE GeneReport for Unigene cluster: Hs.592142
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9Tissue specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expressionin brain, and very low in lung, liver and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA3 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA3 |
Orthologs
for NCOA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NCOA3 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NCOA31 |
nuclear receptor coactivator 3 |
75.04(n)
77.86(a) |
|
419208 XM_417385.3 XP_417385.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NCOA36 |
-- |
73(a) |
1 ↔ 1 |
4(145286436-145315821) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3980212 |
retinoid X receptor-interacting coactivator xSRC-3 |
75.24(n) |
|
AF044080.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ncoa31 |
nuclear receptor coactivator 3 |
59.63(n)
58.05(a) |
|
564519 XM_687846.5 XP_692938.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
tai6 |
taiman |
11(a) |
1 → many |
2L(9166778-9250211) |
ENSEMBL Gene Tree for NCOA3 (if available)
TreeFam Gene Tree for NCOA3 (if available) |
Paralogs
for NCOA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCOA3 gene
- NCOA12 NCOA22
2 SIMAP similar genes for NCOA3 using alignment to 4 protein entries: NCOA3_HUMAN (see all proteins):NCOA2 NCOA1
NCOA3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NCOA3
PGOHUM00000249784
|
Genomic Variants
for NCOA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: NCOA3_HUMAN, Q9Y6Q9Polymorphism: The length of the poly-Gln region is polymorphic in the normal population
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCOA3 (46130601 - 46285621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for NCOA3
7 CNVs: 4103 6114 90591 79224 90590 7309 6115
Human Gene Mutation Database (HGMD): NCOA3
| SABiosciences Cancer Mutation PCR Assays |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing NCOA3: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA3 |
|
Disorders
/ Diseases
for NCOA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCOA3 for disorders About GeneDecksing
OMIM gene information: 601937
OMIM disorders: --
20/47  diseases for NCOA3 (see all 47): About MalaCardsbreast cancer estrogen-receptor positive breast cancer thyroiditis megaesophagus
esophageal squamous cell carcinoma acute promyelocytic leukemia squamous cell carcinoma myeloid leukemia
breast cancer susceptibility synovial sarcoma acute lymphoblastic leukemia breast-ovarian cancer
ovarian cancer lymphoblastic leukemia chronic myeloid leukemia acute myeloid leukemia
epithelial ovarian cancer endometrial carcinoma endometrial cancer carcinoma
10/28 Novoseek disease relationships for NCOA3 gene (see all 28) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
75.9 |
265 |
18827493 (5), 16670003 (5), 14503806 (5), 19102007 (5) (see all 99) |
| ovarian cancer |
46.2 |
19 |
18798508 (5), 16298470 (3), 17441340 (2), 9252329 (2) (see all 11) |
| tumors |
44.9 |
92 |
12618500 (5), 9865902 (4), 11678305 (4), 11103781 (4) (see all 49) |
| mammary tumor |
39.1 |
6 |
20051871 (2), 15380517 (2), 17145884 (1), 14747462 (1) |
| cancer |
36.5 |
46 |
16648476 (3), 17441340 (3), 16539836 (3), 20124470 (2) (see all 19) |
| endometrial cancer |
31.7 |
5 |
17532621 (3), 16980945 (1) |
| prostate cancer |
31.6 |
31 |
16140970 (6), 19305643 (3), 18260363 (2), 20086010 (2) (see all 10) |
| breast carcinoma |
22.2 |
7 |
19491275 (2), 11355743 (2), 11678305 (1), 11221879 (1) |
| endometrial carcinoma |
21.8 |
9 |
16980945 (5), 11355743 (3), 14751175 (1) |
| endometrial hyperplasia |
20.7 |
1 |
16980945 (1) |
Genetic Association Database (GAD): NCOA3
Human Genome Epidemiology (HuGE) Navigator: NCOA3 (34 documents)
Export disorders for NCOA3 gene to outside databases
|
Publications
for NCOA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCOA3 gene, integrated from 9 sources (see all 420):
(articles sorted by number of sources associating them with NCOA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. (PubMed id 9252329)1, 2, 3, 9 Anzick S.L.... Meltzer P.S. (1997)
- TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. (PubMed id 9346901)1, 2, 3 Takeshita A....Chin W.W. (1997)
- Association of NCOA3 polymorphisms with breast cancer risk. (PubMed id 15788663)1, 4, 9 Burwinkel B....Hemminki K. (2005)
- The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (PubMed id 16244359)1, 4, 9 Colilla S....Rebbeck T.R. (2006)
- Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. (PubMed id 15900600)1, 4, 9 Hughes D.J....Sinilnikova O.M. (2005)
- AIB1 polymorphisms predict aggressive ovarian cancer phenotype. (PubMed id 16365010)1, 4, 9 Li A.J....Karlan B.Y. (2005)
- Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (PubMed id 14557830)1, 4, 9 Wasserman L....Pierce J.P. (2004)
- Polymorphic repeat in AIB1 does not alter breast cancer risk. (PubMed id 11056690)1, 4, 9 Haiman C.A....Hunter D.J. (2000)
- Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer-1 (AIB1), are associated with quantitative calcaneal ultrasound. (PubMed id 11092404)1, 4, 9 Patel M.S....Rubin L.A. (2000)
- Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk. (PubMed id 11161840)1, 4, 9 Jernstrom H....Narod S.A. (2001)
|
External Searches for NCOA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCOA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCOA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCOA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NCOA3 gene:
Search GeneIP for patents involving NCOA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCOA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NCOA3 | | OriGene shRNA RFP for NCOA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCOA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA3 | | | OriGene Protein Over-expression Lysate for NCOA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCOA3 | | OriGene 3'-UTR Clone for NCOA3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NCOA3 | | OriGene Custom Protein Services for NCOA3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCOA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCOA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA3 |
| |
 |  |  |  | |
| | Antibodies & Assays for NCOA3 (SRC-3) |
| | | | Tocris compounds for NCOA3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NCOA3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA3 |
|  |  |  | | | | ThermoFisher Antibody for NCOA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA3 |
|
|
|
|
