NCOA2 Gene
protein-coding GIFtS: 63
GCID: GC08M071016
|
|
nuclear receptor coactivator 2
| |
Aliases
for NCOA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Coactivator 21 2 | | Transcriptional Intermediary Factor 22 3 | | TIF21 2 3 5 | | HTIF21 | | NCoA-21 2 3 | | SRC22 5 | | BHLHe751 | | Glucocorticoid Receptor-Interacting Protein-12 | | GRIP11 2 5 | | BHLHE753 | | KAT13C1 2 | | EC 2.3.1.488 | | Class E Basic Helix-Loop-Helix Protein 752 3 | | |
Export aliases for NCOA2 gene to outside databasesPrevious GC identifers: GC08M070125 GC08M070964 GC08M070747 GC08M071074 GC08M071186 GC08M066517 |
Summaries
for NCOA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCOA2:
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclearhormone receptors are conditional transcription factors that play important roles in various aspects of cell growth,development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptorsuperfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurallycharacterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain,and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes calledclass I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571)and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors thatcause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associatedwith target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factorsrequire transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al.,1997 (PubMed 9111344)).(supplied by OMIM, Nov 2010)
UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid bindingdomain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balancebetween white and brown adipose tissues
Gene Wiki entry for NCOA2 (Nuclear receptor coactivator 2)
|
Genomic Views
for NCOA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCOA2 gene promoter:
COUP-TF1 FOXD3 COUP Nkx2-5 HNF-4alpha2 HNF-4alpha1 PPAR-gamma1 COUP-TF PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCOA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.3 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.3NCOA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M071016: view genomic region
(about GC identifiers)
Start:
|
71,021,997 bp from pter |
End:
|
71,316,040 bp from pter |
Size:
|
294,044 bases |
Orientation:
|
minus strand |
|
Proteins
for NCOA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596 (See
protein sequence)Recommended Name: Nuclear receptor coactivator 2 Size: 1464 amino acids; 159157 Da
Subunit: Present in a complex containing CARM1 and EP300/P300, and interacts with CARM1 and NR3C2 (By similarity).Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interactswith HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with ESR1, RARA and RXRA.Interacts with PSMB9 and DDX5
Subcellular location: Nucleus
6/59 PDB 3D structures from  and Proteopedia  for NCOA2 (see all 59):1GWQ (3D)
1GWR (3D)
1M2Z (3D)
1MV9 (3D)
1MVC (3D)
1MZN (3D)
Secondary accessions: Q14CD2Explore the universe of human proteins at neXtProt for NCOA2: NX_Q15596
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15596
2 DME Specific Peptides for NCOA2 (Q15596)
NCOA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006531.1
ENSEMBL proteins: ENSP00000399968 ENSP00000430148 ENSP00000429132 ENSP00000430348 ENSP00000430850 ENSP00000267974 Reactome Protein details: Q15596
Human Recombinant Protein Products for NCOA2:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
NCOA2 for ontologies About GeneDecksing
NCOA2 Antibody Products:
Assay Products for NCOA2: |
Protein
Domains /
Families
for NCOA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCOA2 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q15596ProtoNet protein and cluster: Q15596 4 Blocks protein families: IPB000014 PAS domain IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB001610 PAC motif IPB010011 Protein of unknown function DUF1518
UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596Domain: Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association withnuclear receptors and are, at least in part, functionally redundantDomain: The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP bindingDomain: Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independentlySimilarity: Belongs to the SRC/p160 nuclear receptor coactivator familySimilarity: Contains 1 bHLH (basic helix-loop-helix) domainSimilarity: Contains 1 PAS (PER-ARNT-SIM) domain |
Function
for NCOA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCOA2_HUMAN, Q15596Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid bindingdomain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balancebetween white and brown adipose tissues Enzyme Number (IUBMB): EC 2.3.1.482
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
NCOA2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for NCOA2:
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ncoa2):
NCOA2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ncoa2tm1.2Ipc for NCOA2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NCOA2 (NM_006540) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA2 |
|
Pathways & Interactions
for NCOA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Function of MEF2 in T lymphocytes | | | 2 | Development_Ligand-independent activation of ESR1 and ESR2 | | | 3 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 4 | Transcription_Androgen Receptor nuclear signaling | | | 5 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for NCOA2 (see all 7)
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOA2
5/7  GeneGo (Thomson Reuters) Pathways for NCOA2 (see all 7)
5/9  BioSystems Pathways for NCOA2 (see all 9)
5/6 
Reactome Pathways for NCOA2 (see all 6)
NCOA2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/196 Interacting proteins for NCOA2 (Q155961, 2, 3 ENSP000003999684) via UniProtKB, MINT, STRING, and/or I2D (see all 196)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AR | P102751, 2, 3, ENSP000003638224 | EBI-81236,EBI-608057 MINT-49804 I2D:
score=6 STRING: ENSP00000363822 | | ESR1 | P033721, 3, ENSP000002062494 | EBI-81236,EBI-78473 I2D:
score=5 STRING: ENSP00000206249 | | CTNNB1 | P352222, 3, ENSP000003444564 | MINT-49805 I2D:
score=3 STRING: ENSP00000344456 | | NR1H2 | P550552, 3, ENSP000002537274 | MINT-8089920 I2D:
score=1 STRING: ENSP00000253727 | | DDX17 | Q928411, 3, ENSP000003800334 | EBI-81236,EBI-746012 I2D:
score=2 STRING: ENSP00000380033 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 8670870 | | GO:0021549 | cerebellum development |
-- | -- | | GO:0030521 | androgen receptor signaling pathway |
RCA | 19641626 |
NCOA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCOA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCOA2 for compounds About GeneDecksing
 Browse Tocris compounds for NCOA2
10/23 DrugBank Compounds for NCOA2 (see all 23) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID | -- | -- | target | -- | 10592235 | | (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL | -- | -- | target | -- | 10592235 | | (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL | -- | -- | target | -- | 10592235 | | 17-METHYL-17-ALPHA-DIHYDROEQUILENIN | -- | -- | target | -- | 10592235 | | 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE | -- | -- | target | -- | 10592235 | | 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID | -- | -- | target | -- | 10592235 | | 2-chloro-5-nitro-N-phenylbenzamide | -- | -- | target | -- | 10592235 | | 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL | -- | -- | target | -- | 10592235 | | 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL | -- | -- | target | -- | 10592235 | | 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol | -- | -- | target | -- | 10592235 |
10/31 Novoseek chemical compound relationships for NCOA2 gene (see all 31) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| steroid |
73.5 |
98 |
9111344 (5), 11923473 (2), 9482670 (2), 9238002 (2) (see all 53) |
| estrogen |
70.3 |
43 |
11250900 (3), 19198856 (3), 18521745 (3), 18499756 (2) (see all 23) |
| testosterone |
66.7 |
56 |
12588987 (5), 9482670 (2), 17364555 (2), 9920895 (1) (see all 24) |
| bicalutamide |
60.1 |
17 |
19240160 (3), 12376534 (1), 17079484 (1) |
| androstane |
58.9 |
2 |
15591315 (1), 15557560 (1) |
| 4-hydroxytamoxifen |
57.2 |
2 |
10966511 (1), 9875847 (1) |
| retinoid |
53.8 |
12 |
12205093 (1), 15137909 (1), 9111344 (1), 15731352 (1) (see all 8) |
| vitamin d |
48.3 |
10 |
9111344 (2), 9891040 (1), 10825392 (1), 19255064 (1) (see all 6) |
| retinoic acid |
45.9 |
15 |
17389641 (2), 15234273 (2), 10598588 (1), 9920895 (1) (see all 9) |
| tamoxifen |
44.6 |
6 |
10986290 (2), 15060164 (1), 12684393 (1), 12839940 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about NCOA2
|
Transcripts
for NCOA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCOA2 gene: NM_006540.2 Unigene Cluster for NCOA2: Nuclear receptor coactivator 2 Hs.446678 [show with all ESTs]Unigene Representative Sequence: NM_0065409 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452400(uc011lfb.1 uc003xyn.1) ENST00000518287 ENST00000518363
ENST00000521239 ENST00000522054 ENST00000524223 ENST00000519724 ENST00000520416
ENST00000267974
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCOA2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NCOA2 (NM_006540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCOA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA2 |
Additional cDNA sequence: AK021838.1 AK298528.1 AK308426.1 BC114383.1 EF374064.1 X97674.1 6 DOTS entries: DT.444147 DT.70103935 DT.91912103 DT.97773128 DT.101960748 DT.86844966 24/170 AceView cDNA sequences (see all 170): AA972014 AA382803 CB151315 AA292969 BG034089 AI890157 AA455270 CB242420 BM459228 AA557462 AW241303 AA382443 BM728417 BI963844 AI652063 AA338057 BU632095 CB156018 BQ024776 AA382440 AL042565 AL703633 AL712418 AA235760
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA2 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCOA2
|
Expression
for NCOA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCOA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTAAGCA
About this image
See NCOA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCOA2
SOURCE GeneReport for Unigene cluster: Hs.446678
SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCOA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCOA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCOA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA2 |
Orthologs
for NCOA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NCOA2 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ncoa21 , 5 |
nuclear receptor coactivator 21, 5 |
90.26(n)1
94.39(a)1 |
|
1 (4.12 cM)5
179781 NM_008678.21 NP_032704.21
131391055 |
chicken
(Gallus gallus) |
Aves |
NCOA21 |
nuclear receptor coactivator 2 |
83.66(n)
87.26(a) |
|
420176 XM_001231577.2 XP_001231578.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NCOA26 |
-- |
86(a) |
1 ↔ 1 |
4(32164790-32219372) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ncoa2-A2 |
nuclear receptor coactivator 2 |
78.11(n) |
|
AJ243119.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tif22 |
transcriptional intermediary factor 2 |
74.91(n) |
|
81884 AF323989.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
tai6 |
taiman |
12(a) |
1 → many |
2L(9166778-9250211) |
ENSEMBL Gene Tree for NCOA2 (if available)
TreeFam Gene Tree for NCOA2 (if available) |
Paralogs
for NCOA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCOA2 gene
- NCOA32 NCOA12
5 SIMAP similar genes for NCOA2 using alignment to 6 protein entries: NCOA2_HUMAN (see all proteins):MYST3/NCOA2 fusion NCOA3 CLOCK NPAS2 NCOA1
NCOA2 for paralogs About GeneDecksing
|
Genomic Variants
for NCOA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCOA2 (71021997 - 71271997 bp, first 250kb of NCOA2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NCOA2
1 CNV: 6632 | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing NCOA2: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCOA2 |
|
Disorders
/ Diseases
for NCOA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCOA2 for disorders About GeneDecksing
OMIM gene information: 601993
OMIM disorders: --
UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596
Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversioninv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminalpart of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation
20/26  diseases for NCOA2 (see all 26): About MalaCardswolf-hirschhorn syndrome androgen insensitivity syndrome carney complex monocytic leukemia
glucocorticoid resistance breast cancer susceptibility acute myeloid leukemia myeloid leukemia
williams syndrome breast cancer osteonecrosis pituitary tumor
prostate cancer myelodysplastic syndrome leukemia acute leukemia
prostatitis infertility meningioma breast carcinoma
10/16 Novoseek disease relationships for NCOA2 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
45.8 |
15 |
19240160 (2), 17079484 (2), 14871982 (1), 11489729 (1) (see all 6) |
| recurrent prostate cancer |
42.3 |
1 |
11389051 (1) |
| mammary tumor |
38.7 |
3 |
15459252 (1), 9717843 (1), 17635946 (1) |
| breast cancer |
37.4 |
19 |
18521745 (2), 10690532 (1), 19183483 (1), 10598585 (1) (see all 13) |
| leukemogenesis |
34.9 |
1 |
12619166 (1) |
| monocytic leukemia |
34.6 |
2 |
9731070 (1) |
| leukaemia lymphocytic |
5.49 |
1 |
9705873 (1) |
| cancer |
1.61 |
2 |
9705873 (1), 17079484 (1) |
| leukemia |
0 |
5 |
18281529 (1), 17697320 (1), 9731070 (1) |
| necrosis |
0 |
2 |
11489729 (2) |
Human Genome Epidemiology (HuGE) Navigator: NCOA2 (12 documents)
Export disorders for NCOA2 gene to outside databases
|
Publications
for NCOA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCOA2 gene, integrated from 9 sources (see all 349):
(articles sorted by number of sources associating them with NCOA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. (PubMed id 8670870)1, 2, 3, 9 Voegel J.J.... Gronemeyer H. (1996)
- GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. (PubMed id 9111344)1, 3, 9 Hong H....Stallcup M.R. (1997)
- A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. (PubMed id 11250900)1, 2, 9 Watanabe M....Kato S. (2001)
- Redox-regulated recruitment of the transcriptional coactivators CREB- binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PubMed id 10594042)1, 2, 9 Carrero P....Poellinger L. (2000)
- A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. (PubMed id 9558366)1, 2, 9 Carapeti M.... Cross N.C.P. (1998)
- The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. (PubMed id 16957778)1, 2 Zhang H....Shang Y. (2006)
- MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. (PubMed id 15657427)1, 2 Kindle K.B....Heery D.M. (2005)
- MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. (PubMed id 12676584)1, 2 Deguchi K.... Gilliland D.G. (2003)
- Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase. (PubMed id 11971985)1, 2 Wu R.-C....O'Malley B.W. (2002)
- The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. (PubMed id 9430642)1, 2 Voegel J.J....Gronemeyer H. (1998)
|
External Searches for NCOA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCOA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCOA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCOA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NCOA2 gene:
Search GeneIP for patents involving NCOA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCOA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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