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Aliases for NCOA2 Gene

Aliases for NCOA2 Gene

  • Nuclear Receptor Coactivator 2 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 75 3 4
  • Transcriptional Intermediary Factor 2 3 4
  • BHLHe75 3 4
  • NCoA-2 3 4
  • SRC2 3 4
  • TIF2 3 4
  • Glucocorticoid Receptor-Interacting Protein-1 3
  • P160 Steroid Receptor Coactivator 2 3
  • EC 2.3.1.48 58
  • KAT13C 3
  • GRIP1 3
  • HTIF2 4

External Ids for NCOA2 Gene

Previous GeneCards Identifiers for NCOA2 Gene

  • GC08M070964
  • GC08M070747
  • GC08M071074
  • GC08M071186
  • GC08M071016
  • GC08M066517

Summaries for NCOA2 Gene

Entrez Gene Summary for NCOA2 Gene

  • The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for NCOA2 Gene

NCOA2 (Nuclear Receptor Coactivator 2) is a Protein Coding gene. Diseases associated with NCOA2 include Mesenchymal Chondrosarcoma and Indeterminate Cell Histiocytosis. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Metabolism. GO annotations related to this gene include chromatin binding and transcription factor binding. An important paralog of this gene is NCOA3.

UniProtKB/Swiss-Prot for NCOA2 Gene

  • Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Wiki entry for NCOA2 Gene

Additional gene information for NCOA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA2 Gene

Genomics for NCOA2 Gene

Regulatory Elements for NCOA2 Gene

Enhancers for NCOA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H070171 1.4 FANTOM5 Ensembl ENCODE 13.7 +232.0 232048 3 PKNOX1 ATF1 BACH1 CEBPG BMI1 RFX5 ZNF316 FOXK2 NFE2 ATF7 NCOA2 H2AFZP2 BTF3P12
GH08H069832 1 ENCODE 9.7 +571.5 571495 3 HDGF PKNOX1 SIN3A FEZF1 GLI4 ZNF2 YY1 ZNF121 GLIS2 ZNF143 LOC100129096 NCOA2 LOC101929759 GC08P069795 LOC100101127
GH08H070259 0.5 Ensembl 11.4 +146.3 146337 0 PKNOX1 SP7 SPI1 NCOA2 BTF3P12 H2AFZP2
GH08H070216 1.5 FANTOM5 Ensembl ENCODE 1.4 +186.2 186232 5 HDGF PKNOX1 TBL1XR1 BATF TCF12 GLIS2 ATF7 ETV6 RUNX3 IKZF2 NCOA2 BTF3P12 H2AFZP2
GH08H070194 0.4 FANTOM5 2.2 +210.9 210884 0 ATF2 NCOA2 BTF3P12 H2AFZP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCOA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCOA2 Gene

Chromosome:
8
Start:
70,109,762 bp from pter
End:
70,405,437 bp from pter
Size:
295,676 bases
Orientation:
Minus strand

Genomic View for NCOA2 Gene

Genes around NCOA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA2 Gene

Proteins for NCOA2 Gene

  • Protein details for NCOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15596-NCOA2_HUMAN
    Recommended name:
    Nuclear receptor coactivator 2
    Protein Accession:
    Q15596
    Secondary Accessions:
    • Q14CD2

    Protein attributes for NCOA2 Gene

    Size:
    1464 amino acids
    Molecular mass:
    159157 Da
    Quaternary structure:
    • Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NCOA2 Gene

neXtProt entry for NCOA2 Gene

Selected DME Specific Peptides for NCOA2 Gene

Q15596:
  • SHTFNCRML
  • LEALDGFF

Post-translational modifications for NCOA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NCOA2 Gene

Gene Families for NCOA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NCOA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15596

UniProtKB/Swiss-Prot:

NCOA2_HUMAN :
  • Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
Domain:
  • Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
  • The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
  • Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
Family:
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
genes like me logo Genes that share domains with NCOA2: view

Function for NCOA2 Gene

Molecular function for NCOA2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Enzyme Numbers (IUBMB) for NCOA2 Gene

Phenotypes From GWAS Catalog for NCOA2 Gene

Gene Ontology (GO) - Molecular Function for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IEA,NAS 9430642
genes like me logo Genes that share ontologies with NCOA2: view
genes like me logo Genes that share phenotypes with NCOA2: view

Animal Models for NCOA2 Gene

MGI Knock Outs for NCOA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCOA2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NCOA2
  • Applied Biological Materials Clones for NCOA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOA2 Gene

Localization for NCOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016604 nuclear body IDA --
GO:0043234 protein complex IMP 15641800
genes like me logo Genes that share ontologies with NCOA2: view

Pathways & Interactions for NCOA2 Gene

genes like me logo Genes that share pathways with NCOA2: view

SIGNOR curated interactions for NCOA2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 8670870
GO:0007623 circadian rhythm IEA --
GO:0010906 regulation of glucose metabolic process IEA --
genes like me logo Genes that share ontologies with NCOA2: view

Drugs & Compounds for NCOA2 Gene

(45) Drugs for NCOA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diethylstilbestrol Approved Pharma Agonist, Target 5
Estradiol Approved, Investigational, Vet_approved Pharma Target Sex hormone 1357
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Experimental Pharma Target 0
(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL Experimental Pharma Target 0
(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL Experimental Pharma Target 0

(8) Additional Compounds for NCOA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOA2: view

Transcripts for NCOA2 Gene

Unigene Clusters for NCOA2 Gene

Nuclear receptor coactivator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NCOA2
  • Applied Biological Materials Clones for NCOA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:

ExUns: 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NCOA2 Gene

GeneLoc Exon Structure for
NCOA2
ECgene alternative splicing isoforms for
NCOA2

Expression for NCOA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCOA2 Gene

This gene is overexpressed in Esophagus (49.8) and Serum (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOA2 Gene



Protein tissue co-expression partners for NCOA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCOA2 Gene:

NCOA2

SOURCE GeneReport for Unigene cluster for NCOA2 Gene:

Hs.446678

Evidence on tissue expression from TISSUES for NCOA2 Gene

  • Liver(4.4)
  • Nervous system(2.5)
  • Kidney(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NCOA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA2 Gene

Orthologs for NCOA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA2 33 34
  • 99.93 (n)
dog
(Canis familiaris)
Mammalia NCOA2 33 34
  • 93.94 (n)
oppossum
(Monodelphis domestica)
Mammalia NCOA2 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa2 33 16 34
  • 90.13 (n)
cow
(Bos Taurus)
Mammalia NCOA2 33 34
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia Ncoa2 33
  • 88.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves NCOA2 33 34
  • 83.62 (n)
lizard
(Anolis carolinensis)
Reptilia NCOA2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa2 33
  • 74.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia ncoa2-A 33
zebrafish
(Danio rerio)
Actinopterygii ncoa2 33 34
  • 64.82 (n)
tif2 33
Species where no ortholog for NCOA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA2 Gene

ENSEMBL:
Gene Tree for NCOA2 (if available)
TreeFam:
Gene Tree for NCOA2 (if available)

Paralogs for NCOA2 Gene

Paralogs for NCOA2 Gene

(5) SIMAP similar genes for NCOA2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NCOA2: view

Variants for NCOA2 Gene

Sequence variations from dbSNP and Humsavar for NCOA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000014334 -- 70,136,002(+) AGCAG(C/T)TACTG intron-variant
rs1000021309 -- 70,265,850(+) TTTTT(-/AA)AGAGA intron-variant
rs1000021761 -- 70,158,594(+) AGGCC(A/C)AGGTG intron-variant
rs1000024047 -- 70,225,395(+) AATAC(A/C)AAAAT intron-variant, upstream-variant-2KB
rs1000031129 -- 70,113,960(+) AATTT(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA2 Gene

Variant ID Type Subtype PubMed ID
dgv1404e214 CNV loss 21293372
esv2737143 CNV deletion 23290073
esv3572808 CNV loss 25503493
esv3617565 CNV gain 21293372
nsv1024295 CNV gain 25217958
nsv1068714 OTHER inversion 25765185
nsv1075557 CNV deletion 25765185
nsv1126855 CNV deletion 24896259
nsv1137614 CNV deletion 24896259
nsv1145196 CNV deletion 24896259
nsv397839 CNV deletion 16902084
nsv472609 CNV novel sequence insertion 20440878
nsv508513 CNV deletion 20534489
nsv6246 CNV insertion 18451855
nsv6247 CNV deletion 18451855
nsv6248 CNV deletion 18451855
nsv831352 CNV gain 17160897
nsv951442 CNV duplication 24416366
nsv967603 CNV duplication 23825009

Variation tolerance for NCOA2 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA2 Gene

Disorders for NCOA2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NCOA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mesenchymal chondrosarcoma
  • chondrosarcoma mesenchymal
indeterminate cell histiocytosis
  • indeterminate dendritic cell tumor
chondrosarcoma
  • chondrosarcoma of bone
periosteal chondrosarcoma
  • juxtacortical chondrosarcoma
meninges hemangiopericytoma
  • hemangiopericytoma of meninges
- elite association - COSMIC cancer census association via MalaCards
Search NCOA2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NCOA2_HUMAN
  • Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. {ECO:0000269 PubMed:12676584, ECO:0000269 PubMed:15657427, ECO:0000269 PubMed:9558366}.

Relevant External Links for NCOA2

Genetic Association Database (GAD)
NCOA2
Human Genome Epidemiology (HuGE) Navigator
NCOA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA2
genes like me logo Genes that share disorders with NCOA2: view

No data available for Genatlas for NCOA2 Gene

Publications for NCOA2 Gene

  1. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. (PMID: 8670870) Voegel JJ … Gronemeyer H (The EMBO journal 1996) 2 3 4 22 60
  2. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 45 60
  3. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PMID: 19255064) Ahn J … Prostate, Lung, Colorectal and Ovarian Trial Project Team (Carcinogenesis 2009) 3 22 45 60
  4. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. (PMID: 9111344) Hong H … Stallcup MR (Molecular and cellular biology 1997) 2 3 22 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for NCOA2 Gene

  • Addgene plasmids for NCOA2

Sources for NCOA2 Gene

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