Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCOA2 Gene

Aliases for NCOA2 Gene

  • Nuclear Receptor Coactivator 2 2 3
  • SRC2 3 4 6
  • TIF2 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 75 3 4
  • Transcriptional Intermediary Factor 2 3 4
  • BHLHe75 3 4
  • NCoA-2 3 4
  • GRIP1 3 6
  • HTIF2 3 4
  • Glucocorticoid Receptor-Interacting Protein-1 3
  • EC 2.3.1.48 63
  • KAT13C 3

External Ids for NCOA2 Gene

Previous GeneCards Identifiers for NCOA2 Gene

  • GC08M070964
  • GC08M070747
  • GC08M071074
  • GC08M071186
  • GC08M071016
  • GC08M066517

Summaries for NCOA2 Gene

Entrez Gene Summary for NCOA2 Gene

  • The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]

GeneCards Summary for NCOA2 Gene

NCOA2 (Nuclear Receptor Coactivator 2) is a Protein Coding gene. Diseases associated with NCOA2 include spindle cell rhabdomyosarcoma and mesenchymal chondrosarcoma. Among its related pathways are L1CAM interactions and GPCR Pathway. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is NCOA1.

UniProtKB/Swiss-Prot for NCOA2 Gene

  • Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Wiki entry for NCOA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA2 Gene

Genomics for NCOA2 Gene

Regulatory Elements for NCOA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCOA2 Gene

Start:
70,109,762 bp from pter
End:
70,403,827 bp from pter
Size:
294,066 bases
Orientation:
Minus strand

Genomic View for NCOA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA2 Gene

Proteins for NCOA2 Gene

  • Protein details for NCOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15596-NCOA2_HUMAN
    Recommended name:
    Nuclear receptor coactivator 2
    Protein Accession:
    Q15596
    Secondary Accessions:
    • Q14CD2

    Protein attributes for NCOA2 Gene

    Size:
    1464 amino acids
    Molecular mass:
    159157 Da
    Quaternary structure:
    • Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NCOA2 Gene

neXtProt entry for NCOA2 Gene

Proteomics data for NCOA2 Gene at MOPED

Selected DME Specific Peptides for NCOA2 Gene

Post-translational modifications for NCOA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for NCOA2 Gene

Gene Families for NCOA2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases

Suggested Antigen Peptide Sequences for NCOA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15596

UniProtKB/Swiss-Prot:

NCOA2_HUMAN :
  • Q15596
Domain:
  • Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
  • The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
  • Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
genes like me logo Genes that share domains with NCOA2: view

Function for NCOA2 Gene

Molecular function for NCOA2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Enzyme Numbers (IUBMB) for NCOA2 Gene

Gene Ontology (GO) - Molecular Function for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity NAS 9430642
GO:0004402 histone acetyltransferase activity IEA --
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with NCOA2: view
genes like me logo Genes that share phenotypes with NCOA2: view

Animal Models for NCOA2 Gene

MGI Knock Outs for NCOA2:

Animal Model Products

CRISPR Products

miRNA for NCOA2 Gene

miRTarBase miRNAs that target NCOA2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for NCOA2 Gene

Localization for NCOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA2 Gene COMPARTMENTS Subcellular localization image for NCOA2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NCOA2: view

Pathways for NCOA2 Gene

genes like me logo Genes that share pathways with NCOA2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for NCOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8670870
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with NCOA2: view

Compounds for NCOA2 Gene

(31) Novoseek inferred chemical compound relationships for NCOA2 Gene

Compound -log(P) Hits PubMed IDs
steroid 73.5 61
estrogen 70.3 31
testosterone 66.7 30
bicalutamide 60.1 5
androstane 58.9 2
genes like me logo Genes that share compounds with NCOA2: view

Transcripts for NCOA2 Gene

Unigene Clusters for NCOA2 Gene

Nuclear receptor coactivator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCOA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:

ExUns: 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NCOA2 Gene

GeneLoc Exon Structure for
NCOA2
ECgene alternative splicing isoforms for
NCOA2

Expression for NCOA2 Gene

mRNA expression in normal human tissues for NCOA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA2 Gene

SOURCE GeneReport for Unigene cluster for NCOA2 Gene Hs.446678

genes like me logo Genes that share expressions with NCOA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCOA2 Gene

Orthologs for NCOA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA2 35
  • 99.93 (n)
  • 100 (a)
NCOA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCOA2 35
  • 89.64 (n)
  • 93.92 (a)
NCOA2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA2 35
  • 93.94 (n)
  • 97.27 (a)
NCOA2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa2 35
  • 90.13 (n)
  • 94.19 (a)
Ncoa2 16
Ncoa2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ncoa2 35
  • 88.8 (n)
  • 92.9 (a)
chicken
(Gallus gallus)
Aves NCOA2 35
  • 83.62 (n)
  • 87.19 (a)
NCOA2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ncoa2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa2 35
  • 74.87 (n)
  • 76.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ncoa2 35
  • 64.82 (n)
  • 63.45 (a)
ncoa2 36
  • 59 (a)
OneToOne
tif2 35
Species with no ortholog for NCOA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA2 Gene

ENSEMBL:
Gene Tree for NCOA2 (if available)
TreeFam:
Gene Tree for NCOA2 (if available)

Paralogs for NCOA2 Gene

Paralogs for NCOA2 Gene

Selected SIMAP similar genes for NCOA2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NCOA2: view

Variants for NCOA2 Gene

Sequence variations from dbSNP and Humsavar for NCOA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9572 -- 70,167,250(+) TTTAG(A/G)CTTGA intron-variant
rs716478 -- 70,194,835(+) CCCAA(C/T)TGACT intron-variant
rs716741 -- 70,194,679(+) ttctt(C/T)ttttt intron-variant
rs726285 -- 70,158,952(-) CTAGT(G/T)AATTG intron-variant
rs877181 -- 70,165,053(-) AAGTA(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA2 Gene

Variant ID Type Subtype PubMed ID
nsv508513 CNV Loss 20534489
nsv831352 CNV Gain 17160897
nsv6246 CNV Insertion 18451855
nsv6247 CNV Loss 18451855
nsv397839 CNV Loss 16902084
nsv6248 CNV Loss 18451855
esv2737143 CNV Deletion 23290073
dgv7805n71 CNV Gain 21882294

Relevant External Links for NCOA2 Gene

HapMap Linkage Disequilibrium report
NCOA2

PCR Panel Products

  • Copy Number PCR Panels: for NCOA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA2 Gene

Disorders for NCOA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for NCOA2 Gene including...

Search for NCOA2 Gene in MalaCards »

UniProtKB/Swiss-Prot

NCOA2_HUMAN
  • Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

(2) University of Copenhagen DISEASES for NCOA2 Gene

(16) Novoseek inferred disease relationships for NCOA2 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 45.8 8
recurrent prostate cancer 42.3 1
mammary tumor 38.7 3
breast cancer 37.4 14
leukemogenesis 34.9 1

Relevant External Links for NCOA2

Genetic Association Database (GAD)
NCOA2
Human Genome Epidemiology (HuGE) Navigator
NCOA2
genes like me logo Genes that share disorders with NCOA2: view

Publications for NCOA2 Gene

  1. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. (PMID: 8670870) Voegel J.J. … Gronemeyer H. (EMBO J. 1996) 2 3 4 23
  2. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. (PMID: 9111344) Hong H. … Stallcup M.R. (Mol. Cell. Biol. 1997) 2 3 23
  3. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman C.A. … Press M.F. (BMC Cancer 2009) 3 23 48
  4. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PMID: 19255064) Ahn J. … Hayes R.B. (Carcinogenesis 2009) 3 23 48
  5. Estrogen signaling in colorectal carcinoma microenvironment: expression of ERbeta1, AIB-1, and TIF-2 is upregulated in cancer-associated myofibroblasts and correlates with disease progression. (PMID: 19277704) Tzelepi V. … Sotiropoulou-Bonikou G. (Virchows Arch. 2009) 3 23

Products for NCOA2 Gene

Sources for NCOA2 Gene

Back to Top

Content