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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA2 Gene

protein-coding   GIFtS: 67
GCID: GC08M071016

Nuclear Receptor Coactivator 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Coactivator 21 2     GRIP12 5
TIF22 3 5     SRC22 5
Class E Basic Helix-Loop-Helix Protein 752 3     KAT13C2
Transcriptional Intermediary Factor 22 3     Glucocorticoid Receptor-Interacting Protein-12
NCoA-22 3     BHLHE753
bHLHe752 3     EC 2.3.1.488
hTIF22 3     

External Ids:    HGNC: 76691   Entrez Gene: 104992   Ensembl: ENSG000001403967   OMIM: 6019935   UniProtKB: Q155963   

Export aliases for NCOA2 gene to outside databases

Previous GC identifers: GC08M070125 GC08M070964 GC08M070747 GC08M071074 GC08M071186 GC08M066517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCOA2 Gene:
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors.
Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of
cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear
hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below),
are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central
DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors,
which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with
heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical
conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as
homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's
transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator
proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 (PubMed 9111344)).(supplied
by OMIM, Nov 2010)

GeneCards Summary for NCOA2 Gene: 
NCOA2 (nuclear receptor coactivator 2) is a protein-coding gene. Diseases associated with NCOA2 include mesenchymal chondrosarcoma, and carney complex, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is NCOA3.

UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596
Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid
binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy
balance between white and brown adipose tissues

Gene Wiki entry for NCOA2 (Nuclear receptor coactivator 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA2 gene promoter:
         COUP-TF1   FOXD3   COUP   Nkx2-5   HNF-4alpha2   HNF-4alpha1   PPAR-gamma1   COUP-TF   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NCOA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.3   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13.3

NCOA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M071016:  view genomic region     (about GC identifiers)

Start:
71,021,997 bp from pter      End:
71,316,040 bp from pter
Size:
294,044 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 2  
Size: 1464 amino acids; 159157 Da
Subunit: Present in a complex containing CARM1 and EP300/P300, and interacts with CARM1 and NR3C2 (By similarity).
Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP.
Interacts with HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with ESR1, RARA
and RXRA. Interacts with PSMB9 and DDX5
Subcellular location: Nucleus
6/74 PDB 3D structures from and Proteopedia for NCOA2 (see all 74):
1GWQ (3D)        1GWR (3D)        1M2Z (3D)        1MV9 (3D)        1MVC (3D)        1MZN (3D)    
Secondary accessions: Q14CD2

Explore the universe of human proteins at neXtProt for NCOA2: NX_Q15596

Explore proteomics data for NCOA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15596

  • 2 DME Specific Peptides for NCOA2 (Q15596)
     LEALDGFF  SHTFNCRML 

    NCOA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCOA2 Protein Expression
    REFSEQ proteins: NP_006531.1  
    ENSEMBL proteins: 
     ENSP00000399968   ENSP00000430148   ENSP00000429132   ENSP00000430348   ENSP00000430850  
     ENSP00000267974  
    Reactome Protein details: Q15596
    Human Recombinant Protein Products for NCOA2: 
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    OriGene Protein Over-expression Lysate for NCOA2
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    Novus Biologicals NCOA2 Protein
    Novus Biologicals NCOA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOA2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    NCOA2 for ontologies           About GeneDecksing



    NCOA2 Antibody Products: 
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    Assay Products for NCOA2: 
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    Cloud-Clone Corp. ELISAs for NCOA2 
    Cloud-Clone Corp. CLIAs for NCOA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    bHLH: Basic helix-loop-helix proteins

    5/10 InterPro protein domains (see all 10):
     IPR008955 Src1_rcpt_coact
     IPR010011 DUF1518
     IPR014935 SRC-1
     IPR001610 PAC
     IPR014920 Nuc_rcpt_coact_Ncoa-typ

    Graphical View of Domain Structure for InterPro Entry Q15596

    ProtoNet protein and cluster: Q15596

    4 Blocks protein domains:
    IPB000014 PAS domain
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB010011 Protein of unknown function DUF1518


    UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596
    Domain: Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with
    nuclear receptors and are, at least in part, functionally redundant
    Domain: The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding
    Domain: Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently
    Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    NCOA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA2_HUMAN, Q15596
    Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid
    binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy
    balance between white and brown adipose tissues

         Enzyme Number (IUBMB): EC 2.3.1.482

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity NAS9430642
    GO:0004402histone acetyltransferase activity IEA--
    GO:0004871signal transducer activity IEA--
         
    NCOA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCOA2:
     Increased viability after born 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ncoa2):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  growth/size  immune system 
     integument  no phenotypic analysis  reproductive system 

    NCOA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ncoa2tm1.2Ipc for NCOA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NCOA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCOA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCOA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCOA2 

    miRNA
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    miRTarBase miRNAs that target NCOA2:
    hsa-mir-137 (MIRT004004)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA2
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA2 (see all 38):
    hsa-miR-429 hsa-miR-875-5p hsa-miR-218-1* hsa-miR-374c hsa-miR-3658 hsa-miR-4325 hsa-miR-186 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNCOA2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NCOA2 (NM_006540)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCOA2 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Immune response Function of MEF2 in T lymphocytes
    Immune response Function of MEF2 in T lymphocytes0.90
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.38
    4Axon guidance
    Developmental Biology0.69
    5GPCR Pathway
    Estrogen Pathway0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for NCOA2 (see all 7)
        Transcription Androgen Receptor nuclear signaling
    Development Glucocorticoid receptor signaling
    Immune response Function of MEF2 in T lymphocytes
    Development Ligand-dependent activation of the ESR1/AP-1 pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOA2
        AHR Pathway
    Androgen Signaling
    Estrogen Pathway

    5/7 GeneGo (Thomson Reuters) Pathways for NCOA2 (see all 7)
        Transcription Androgen Receptor nuclear signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Development Ligand-dependent activation of the ESR1/AP-1 pathway

    5/9 BioSystems Pathways for NCOA2 (see all 9)
        Adipogenesis
    Androgen receptor signaling pathway
    Regulation of Androgen receptor activity
    Glucocorticoid receptor regulatory network
    Retinoic acid receptors-mediated signaling

    5/6        Reactome Pathways for NCOA2 (see all 6)
        Developmental Biology
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Transcriptional Regulation of White Adipocyte Differentiation
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism



    NCOA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/204 Interacting proteins for NCOA2 (Q155961, 2, 3 ENSP000003999684) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 2, 3, ENSP000003638224EBI-81236,EBI-608057 MINT-49804 I2D: score=6 STRING: ENSP00000363822
    PSMB9P280653, ENSP000003639934I2D: score=1 STRING: ENSP00000363993
    ENSG00000239836P280653I2D: score=1 
    ENSG00000240118P280653I2D: score=1 
    ENSG00000240508P280653I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS8670870
    GO:0007165signal transduction ----
    GO:0030521androgen receptor signaling pathway RCA19641626

    NCOA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCOA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCOA2

    10/23 DrugBank Compounds for NCOA2 (see all 23)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID-- --target--10592235
    (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL-- --target--10592235
    (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL-- --target--10592235
    17-METHYL-17-ALPHA-DIHYDROEQUILENIN-- --target--10592235
    2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE-- --target--10592235
    2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID-- --target--10592235
    2-chloro-5-nitro-N-phenylbenzamide-- --target--10592235
    3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL-- --target--10592235
    3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL-- --target--10592235
    4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol-- --target--10592235

    10/31 Novoseek inferred chemical compound relationships for NCOA2 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 73.5 98 9111344 (5), 11923473 (2), 9482670 (2), 9238002 (2) (see all 53)
    estrogen 70.3 43 11250900 (3), 19198856 (3), 18521745 (3), 18499756 (2) (see all 23)
    testosterone 66.7 56 12588987 (5), 9482670 (2), 17364555 (2), 9920895 (1) (see all 24)
    bicalutamide 60.1 17 19240160 (3), 12376534 (1), 17079484 (1)
    androstane 58.9 2 15591315 (1), 15557560 (1)
    4-hydroxytamoxifen 57.2 2 10966511 (1), 9875847 (1)
    retinoid 53.8 12 12205093 (1), 15137909 (1), 9111344 (1), 15731352 (1) (see all 8)
    vitamin d 48.3 10 9111344 (2), 9891040 (1), 10825392 (1), 19255064 (1) (see all 6)
    retinoic acid 45.9 15 17389641 (2), 15234273 (2), 10598588 (1), 9920895 (1) (see all 9)
    tamoxifen 44.6 6 10986290 (2), 15060164 (1), 12684393 (1), 12839940 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about NCOA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCOA2 gene: 
    NM_006540.2  

    Unigene Cluster for NCOA2:

    Nuclear receptor coactivator 2
    Hs.446678  [show with all ESTs]
    Unigene Representative Sequence: NM_006540
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452400(uc011lfb.1 uc003xyn.1) ENST00000518287 ENST00000518363
    ENST00000521239 ENST00000522054 ENST00000524223 ENST00000519724 ENST00000520416
    ENST00000267974
    miRNA
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    hsa-miR-429 hsa-miR-875-5p hsa-miR-218-1* hsa-miR-374c hsa-miR-3658 hsa-miR-4325 hsa-miR-186 hsa-miR-155*
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCOA2

    Additional mRNA sequence: 

    AK021838.1 AK298528.1 AK308426.1 BC114383.1 EF374064.1 X97674.1 

    6 DOTS entries:

    DT.444147  DT.70103935  DT.91912103  DT.97773128  DT.101960748  DT.86844966 

    24/170 AceView cDNA sequences (see all 170):

    CB151315 AA338057 BM728417 AA382440 BQ024776 AL042565 AL703633 BQ420460 
    AL712418 AA235760 AI078795 AA398376 BU159029 BU742199 BQ023970 CA395894 
    BM975601 CK903770 AA994479 BX113045 AA382384 AI393449 BI963844 AI652063 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^
    SP1:        -           -                                                                                                           -                           
    SP2:                                                                                                        -                       -                           
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NCOA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA2 expression in normal human tissues (normalized intensities)      NCOA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTAAGCA
    NCOA2 Expression
    About this image


    NCOA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             neutrophils   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Ovary (Reproductive System)
             oocyte   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/bladder/vasculature of bladder   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See NCOA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA2

    SOURCE GeneReport for Unigene cluster: Hs.446678
        SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA2: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa21 , 5 nuclear receptor coactivator 21, 5 90.26(n)1
    94.39(a)1
      1 (4.12 cM)5
    179781  NM_008678.21  NP_032704.21 
     131391055 
    chicken
    (Gallus gallus)
    Aves NCOA21 nuclear receptor coactivator 2 83.66(n)
    87.26(a)
      420176  XM_001231577.2  XP_001231578.2 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    4(32160745-32307519)
    African clawed frog
    (Xenopus laevis)
    Amphibia ncoa2-A2 nuclear receptor coactivator 2 78.11(n)    AJ243119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tif22 transcriptional intermediary factor 2 74.91(n)   81884  AF323989.1 


    ENSEMBL Gene Tree for NCOA2 (if available)
    TreeFam Gene Tree for NCOA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCOA2 gene
    NCOA32  NCOA12  
    5 SIMAP similar genes for NCOA2 using alignment to 6 protein entries:     NCOA2_HUMAN (see all proteins):
    MYST3/NCOA2 fusion    NCOA3    CLOCK    NPAS2    NCOA1

    NCOA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5479 SNPs in NCOA2 are shown (see all 5479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32154301,2
    C--66532109(-) GTCTT-/ACTT  
            
    TAAGA
    1 -- int10--------
    rs715604041,2
    C--66803006(+) AAAGG-/A/AAA 
            
    AAAAA
    1 -- int11NA 2
    rs29547281,2
    C,H--71023866(+) TGCAAA/CTTTCC 1 -- ds50016Minor allele frequency- C:0.00NS EA NA 378
    rs1481246701,2
    --71023881(+) AGGTTC/TTTTAG 1 -- ds50010--------
    rs1830727171,2
    --71023956(+) TTCCAC/TAATGC 1 -- ds50010--------
    rs1439903231,2
    --71023961(+) TAATGC/TGTACA 1 -- ds50010--------
    rs1864473391,2
    --71023998(+) GGGGTA/TGTTTG 1 -- ds50010--------
    rs1916815761,2
    --71024021(+) CCTGCC/GACAAA 1 -- ds50010--------
    rs37502001,2
    C,F,H--71024034(+) AACAAA/TCAATC 1 -- ds50015Minor allele frequency- T:0.01EA NS 1168
    rs1829971021,2
    --71024063(+) TCTCTG/TTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NCOA2 (71021997 - 71271997 bp, first 250kb of NCOA2)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NCOA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737143CNV Deletion23290073
    nsv6246CNV Insertion18451855
    nsv6248CNV Loss18451855
    nsv6247CNV Loss18451855
    nsv397839CNV Loss16902084
    nsv508513CNV Loss20534489
    dgv7805n71CNV Gain21882294
    nsv831352CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing NCOA2:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing NCOA2
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601993    OMIM disorders: --

    UniProtKB/Swiss-Prot: NCOA2_HUMAN, Q15596
  • Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion
    inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the
    C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation

  • 20/30 diseases for NCOA2 (see all 30):    About MalaCards
    mesenchymal chondrosarcoma    carney complex    androgen insensitivity syndrome    glucocorticoid resistance
    wolf-hirschhorn syndrome    osteonecrosis    williams syndrome    monocytic leukemia
    breast cancer susceptibility    pituitary tumors    prostate cancer    chondrosarcoma
    myelodysplastic syndromes    acute leukemia    acute myeloid leukemia    breast cancer
    infertility    meningioma    kaposi's sarcoma    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for NCOA2:
    Mesenchymal chondrosarcoma     Wolf-Hirschhorn syndrome

    NCOA2 for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for NCOA2 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 45.8 15 19240160 (2), 17079484 (2), 14871982 (1), 11489729 (1) (see all 6)
    recurrent prostate cancer 42.3 1 11389051 (1)
    mammary tumor 38.7 3 15459252 (1), 9717843 (1), 17635946 (1)
    breast cancer 37.4 19 18521745 (2), 10690532 (1), 19183483 (1), 10598585 (1) (see all 13)
    leukemogenesis 34.9 1 12619166 (1)
    monocytic leukemia 34.6 2 9731070 (1)
    leukaemia lymphocytic 5.49 1 9705873 (1)
    cancer 1.61 2 9705873 (1), 17079484 (1)
    leukemia 0 5 18281529 (1), 17697320 (1), 9731070 (1)
    necrosis 0 2 11489729 (2)

    Genetic Association Database (GAD): NCOA2
    Human Genome Epidemiology (HuGE) Navigator: NCOA2 (12 documents)

    Export disorders for NCOA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCOA2 gene, integrated from 9 sources (see all 364):
    (articles sorted by number of sources associating them with NCOA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. (PubMed id 8670870)1, 2, 3, 9 Voegel J.J.... Gronemeyer H. (1996)
    2. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. (PubMed id 9111344)1, 3, 9 Hong H....Stallcup M.R. (1997)
    3. A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. (PubMed id 11250900)1, 2, 9 Watanabe M....Kato S. (2001)
    4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (2009)
    5. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PubMed id 19255064)1, 4, 9 Ahn J....Hayes R.B. (2009)
    6. Redox-regulated recruitment of the transcriptional coactivators CREB- binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PubMed id 10594042)1, 2, 9 Carrero P....Poellinger L. (2000)
    7. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. (PubMed id 9558366)1, 2, 9 Carapeti M.... Cross N.C.P. (1998)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10499 HGNC: 7669 AceView: NCOA2 Ensembl:ENSG00000140396 euGenes: HUgn10499
    ECgene: NCOA2 H-InvDB: NCOA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCOA2 gene:
    Search GeneIP for patents involving NCOA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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