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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCOA1 Gene

protein-coding   GIFtS: 68
GCID: GC02P024719

nuclear receptor coactivator 1
 Explore 41 diseases affiliated with
NCOA1 via
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 Human Malady Compendium 
Biological research products
for NCOA1    

Aliases
for NCOA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Coactivator 11 2     EC 2.3.1.483 8
SRC11 2 3 5     BHLHe421
RIP1601 2 3     Hin-2 Protein2
BHLHe741     PAX3/NCOA1 Fusion Protein2
F-SRC-11 2     Steroid Receptor Coactivator-12
KAT13A1 2     BHLHE743
NCoA-11 3     SRC-13
Class E Basic Helix-Loop-Helix Protein 742 3     Protein Hin-23
Renal Carcinoma Antigen NY-REN-522 3     Steroid Receptor Coactivator 13

External Ids:    HGNC: 76681   Entrez Gene: 86482   Ensembl: ENSG000000846767   OMIM: 6026915   UniProtKB: Q157883   

Export aliases for NCOA1 gene to outside databases

Previous GC identifers: GC02P024728 GC02P024899 GC02P024781 GC02P024568 GC02P024545


Summaries
for NCOA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NCOA1:
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is
a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone
acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of
this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent
fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for
steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in
coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase
activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating
multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both
chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance
between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher
thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3

Gene Wiki entry for NCOA1 (Nuclear receptor coactivator 1)


Genomic Views
for NCOA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCOA1 gene promoter:
         CREB   STAT5B   AP-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCOA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCOA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCOA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

NCOA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P024719:  view genomic region     (about GC identifiers)

Start:
 24,714,783 bp from pter      End:
 24,993,571 bp from pter
Size:
 278,789 bases      Orientation:
 plus strand

Proteins
for NCOA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 1  
Size: 1441 amino acids; 156757 Da
Subunit: Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the
FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6
stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300
and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they
functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5.
Interacts with ASXL1
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAA64187.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC50305.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/98 PDB 3D structures from and Proteopedia for NCOA1 (see all 98):
1FM6 (3D)        1FM9 (3D)        1K4W (3D)        1K74 (3D)        1K7L (3D)        1KV6 (3D)    
Secondary accessions: O00150 O43792 O43793 Q13071 Q13420 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3
Alternative splicing: 3 isoforms:  Q15788-1   Q15788-2   Q15788-3   (Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation)

Explore the universe of human proteins at neXtProt for NCOA1: NX_Q15788

Post-translational modifications:

  • Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not
    • prevent its ubiquitination and does not exert a clear effect on the stability of the protein1
  • Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15788

    • 4/5 DME Specific Peptides for NCOA1 (Q15788) (see all 5)
     LEALDGFF  EKRRREQE  SHTFNCRML  NTSVYSILH 

    NCOA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_003734.3  NP_671756.1  NP_671766.1  

    ENSEMBL proteins: 
     ENSP00000385216   ENSP00000385097   ENSP00000385195   ENSP00000379197   ENSP00000320940  
     ENSP00000444039   ENSP00000288599  
    Reactome Protein details: Q15788
    Human Recombinant Protein Products: 
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    Novus Biologicals NCOA1 Protein
    Novus Biologicals NCOA1 Lysates
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    Uscn Proteins for NCOA1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA17363140
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--


    NCOA1 for ontologies           About GeneDecksing



    NCOA1 Antibody Products: 
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    Uscn ELISAs and CLIAs for NCOA1

    Protein Domains /
    Families
    for NCOA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NCOA1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR008955 Src1_rcpt_coact
     IPR014920 Nuc_rcpt_coact_Ncoa-typ
     IPR009110 Nuc_rcpt_coact
     IPR013767 PAS_fold
     IPR000014 PAS

    Graphical View of Domain Structure for InterPro Entry Q15788

    ProtoNet protein and cluster: Q15788

    2 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB010011 Protein of unknown function DUF1518


    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
    Domain: The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity
    Domain: Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with
    nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in
    vitro
    Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Function
    for NCOA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for
    steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in
    coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase
    activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating
    multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both
    chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance
    between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher
    thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for NCOA1:
    nuclear steroid receptor coactivator 1,possessing an intrinsic histone acetyltransferase activity,interacting with
    CREBBP and PCAF coactivating PPARG,stimulating gene expression in a hormone dependent fashion by facilitating the
    assembly of basal transcription factors into a stable preinitiation complex,enhancing ligand-dependent and receptor
    dependent cell-free transcription of chromatin,possibly involved in disruption by translocation in hematological
    malignancies

    Enzyme Number (IUBMB): EC 2.3.1.481 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCOA1
    8/153 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA1 (see all 153):
    hsa-miR-631 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-130b hsa-miR-92b hsa-miR-3612 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NCOA1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity NAS15774904
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
    GO:0004402histone acetyltransferase activity IEA--


    NCOA1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NCOA1:
     Decreased viability with cispl  Increased cell death in HCC-19 

    Animal Models:
         Mouse knock-outs for NCOA1: Ncoa1tm1.1Hkaw Ncoa1tm1Bwo Ncoa1tm1Jkr
         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ncoa1):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  integument  nervous system  normal  renal/urinary system 
     reproductive system  skeleton 

    NCOA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NCOA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Ligand-dependent activation of the ESR1/AP-1 pathway
    		Development_Ligand-dependent activation of the ESR1/AP-1 pathway1.00
    		Transcription Ligand-dependent activation of the ESR1/SP pathway0.37
    		Development Ligand-dependent activation of the ESR1/AP-1 pathway1.00
    		Transcription_Ligand-dependent activation of the ESR1/SP pathway0.37
    2Development_Ligand-independent activation of ESR1 and ESR2
    		Development_Ligand-independent activation of ESR1 and ESR21.00
    		Transcription PPAR Pathway0.35
    		Development Ligand-independent activation of ESR1 and ESR20.97
    		Transcription_PPAR Pathway0.35
    3Immune response_MIF-JAB1 signaling
    		Immune response_MIF-JAB1 signaling1.00
    		Immune response MIF-JAB1 signaling0.97
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for NCOA1 (see all 8)
        Transcription PPAR Pathway
    Transcription Androgen Receptor nuclear signaling
    Development Glucocorticoid receptor signaling
    Development Ligand-dependent activation of the ESR1/AP-1 pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCOA1 (see all 9)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway

    1 Cell Signaling Technology (CST) Pathway for NCOA1
        Chromatin Regulation / Acetylation

    5/8 GeneGo (Thomson Reuters) Pathways for NCOA1 (see all 8)
        Transcription Androgen Receptor nuclear signaling
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription PPAR Pathway
    Development Ligand-dependent activation of the ESR1/AP-1 pathway

    5/13 BioSystems Pathways for NCOA1 (see all 13) 
        Adipogenesis
    Energy Metabolism
    IL-6 Signaling Pathway
    Androgen receptor signaling pathway
    Leptin signaling pathway

    5/6        Reactome Pathways for NCOA1 (see all 6)
        Developmental Biology
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Transcriptional Regulation of White Adipocyte Differentiation
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism



    NCOA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCOA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for NCOA1 (Q157881, 2, 3 ENSP000003209404) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H3Q131332, 3MINT-7986700 MINT-7986907 MINT-7986678 MINT-7986760 MINT-7986890 MINT-7986720 MINT-7986621 MINT-7986736 MINT-7986787 MINT-7986596 MINT-7986639 MINT-7986575 MINT-7986555 MINT-7986808 I2D: score=2 
    RXRAP197932, 3, ENSP000004196924MINT-7986700 MINT-7986678 MINT-7986848 MINT-7986760 MINT-5224970 MINT-7986720 MINT-7986865 MINT-7986787 MINT-7986736 MINT-7986639 MINT-7986822 I2D: score=5 STRING: ENSP00000419692
    PSMB9P280652, 3, ENSP000003639934MINT-3291957 MINT-3291505 MINT-3291694 I2D: score=2 STRING: ENSP00000363993
    PAGR1Q9BTK62, 3MINT-7013379 MINT-7013332 MINT-7013538 MINT-7013343 I2D: score=1 
    RARAP102762, 3, ENSP000002540664MINT-2834489 MINT-5209864 I2D: score=6 STRING: ENSP00000254066
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000435positive regulation of transcription from RNA polymerase II promoter by galactose IDA10207113
    GO:0006351transcription, DNA-dependent IDA9223431
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0009725response to hormone stimulus ----
    GO:0021549cerebellum development ----


    NCOA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCOA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCOA1 for compounds           About GeneDecksing

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    Browse Tocris compounds for NCOA1

    2 HMDB Compounds for NCOA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    10/21 DrugBank Compounds for NCOA1 (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE-- --target--10592235
    (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol-- --target--10592235
    (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid-- --target--10592235
    (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID-- --target--10592235
    (5BETA)-PREGNANE-3,20-DIONE-- --target--10592235
    (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid-- --target--10592235
    1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)-- --target--10592235
    1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL-- --target--10592235
    2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL-- --target--10592235
    2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL-- --target--10592235

    10/45 Novoseek chemical compound relationships for NCOA1 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 89 557 17429319 (6), 9575154 (5), 10823935 (3), 16775354 (3) (see all 99)
    citco 85.4 2 16099843 (1), 19820207 (1)
    estrogen 77.1 74 18566116 (4), 15917309 (2), 12943741 (2), 12574227 (2) (see all 46)
    4-hydroxytamoxifen 74.9 19 9171229 (4), 14673139 (2), 8816752 (2), 14715875 (1) (see all 6)
    retinoid 72.4 31 16723356 (2), 9488734 (1), 14715875 (1), 15137909 (1) (see all 19)
    androstane 71.5 1 11256950 (1)
    tcpobop 62.4 1 15272053 (1)
    retinoic acid 61.8 45 15234273 (2), 9171239 (1), 10567404 (1), 10598588 (1) (see all 18)
    progesterone 60.9 24 11606780 (2), 15601848 (1), 15831298 (1), 12574227 (1) (see all 14)
    vitamin d 58.6 13 10406465 (2), 9440810 (1), 10773107 (1), 19255064 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about NCOA1 

    Transcripts
    for NCOA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCOA1 gene (3 alternative transcripts): 
    NM_003743.4  NM_147223.2  NM_147233.2  

    Unigene Cluster for NCOA1:

    Nuclear receptor coactivator 1
    Hs.596314  [show with all ESTs]
    Unigene Representative Sequence: NM_147223
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496333 ENST00000406961(uc002rfk.3 uc002rfl.3) ENST00000469850
    ENST00000405141(uc010eye.3 uc002rfi.3 uc002rfj.3) ENST00000407230
    ENST00000483904 ENST00000395856 ENST00000486198 ENST00000493773 ENST00000348332
    ENST00000538539 ENST00000288599(uc010eyf.3)

    miRNA
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    8/153 QIAGEN miScript miRNA Assays for microRNAs that regulate NCOA1 (see all 153):
    hsa-miR-631 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-130b hsa-miR-92b hsa-miR-3612 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NCOA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AJ000881.1 AJ000882.1 AK226063.1 AK290019.1 BC035976.1 BC111533.1 BC111534.1 U19179.1 
    U40396.1 U59302.1 U90661.1 

    17 DOTS entries:

    DT.92436802  DT.100776908  DT.120988532  DT.75101319  DT.65285527  DT.120988525  DT.118829  DT.80100216 
    DT.120988551  DT.120988562  DT.40304905  DT.92436807  DT.95190028  DT.97765148  DT.120988470  DT.65286022 
    DT.99947551 

    24/325 AceView cDNA sequences (see all 325):

    Z44627 AI087806 AJ000882 AA495962 BC035976 BQ709009 AA828433 BE255183 
    AI804133 BE675555 BE550739 AL045200 BM694051 NM_147233 AI358355 F09468 
    AA701462 AL710016 BQ006325 BQ581670 CB156462 AI214468 BQ421895 AA195707 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NCOA1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:                    -                                                                                                           -     -               
    SP2:                    -                                                                                                           -                     
    SP3:                    -                                                                                                           -     -               
    SP4:                                                                                                                                -                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NCOA1

    Expression
    for NCOA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCOA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCCAATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NCOA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NCOA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCOA1

    SOURCE GeneReport for Unigene cluster: Hs.596314

    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including NCOA1: 
              Parkinson's Disease in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    Orthologs
    for NCOA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NCOA1 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NCOA11 nuclear receptor coactivator 1 71.87(n)
    76.15(a)    		   422016  NM_001012882.1  NP_001012900.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NCOA16
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343333.1(498642-588372)
    zebrafish
    (Danio rerio)    		 Actinopterygii ncoa11 nuclear receptor coactivator 1 54.96(n)
    50.57(a)    		   563288  XM_686652.4  XP_691744.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta tai6
    		 taiman
    		 11(a)
    		 1 → many
    		 2L(9166778-9250211)


    ENSEMBL Gene Tree for NCOA1 (if available)
    TreeFam Gene Tree for NCOA1 (if available) 

    Paralogs
    for NCOA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCOA1 gene
    NCOA32  NCOA22  
    2 SIMAP similar genes for NCOA1 using alignment to 2 protein entries:     NCOA1_HUMAN (see all proteins):
    NCOA2    NCOA3

    NCOA1 for paralogs           About GeneDecksing



    Genomic Variants
    for NCOA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2726 NCBI SNPs in NCOA1 are shown (see all 2726)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs560299411,2
    		C,--24544108(+) ATCACA/GTTATC 3 -- us2k12Minor allele frequency- G:0.01NS 92
    rs556378801,2
    		C,F,--24544435(+) GATTTC/GCTGGC 3 -- us2k13Minor allele frequency- G:0.01NS NA 214
    rs563935691,2
    		C,--24544717(+) TATATG/CGAAAA 3 -- us2k12Minor allele frequency- C:0.01NS 94
    rs558002121,2
    		C,F,--24544804(+) TTATCA/GACAAG 3 -- us2k13Minor allele frequency- G:0.03NS WA 212
    rs558972311,2
    		C,F,--24544996(+) ATGTCG/AAAGAG 3 -- us2k14Minor allele frequency- A:0.05NS WA NA 328
    rs562081421,2
    		C,F,--24545102(+) ATGATA/GTATAT 3 -- us2k13Minor allele frequency- G:0.04NS WA 212
    rs561971421,2
    		C,F,--24545116(+) GAATGG/AAATAC 3 -- us2k13Minor allele frequency- A:0.01NS NA 214
    rs558532871,2
    		C,F,--24545180(+) CCTGGA/TGGACT 3 -- us2k14Minor allele frequency- T:0.06NS WA NA 330
    rs563957471,2
    		C,F,--24546061(+) AACAGT/CTGGGC 3 -- int13Minor allele frequency- C:0.02NS NA 210
    rs134287331,2
    		C,F,H,--24546562(+) ATCCCA/TTTGGG 3 -- int19Minor allele frequency- T:0.01NS EA NA WA CSA 518

    HapMap Linkage Disequilibrium report for NCOA1 (24714783 - 24964783 bp, first 250kb of NCOA1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NCOA1
         1 CNV: 50454
         1 Indel: 26647
    Human Gene Mutation Database (HGMD): NCOA1

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    Disorders / Diseases
    for NCOA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NCOA1 for disorders           About GeneDecksing

    OMIM gene information: 602691    OMIM disorders: --

    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
  • Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23)
    • with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of
    NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue
    carcinoma in childhood, representing 5-8% of all malignancies in children

    20/41 diseases for NCOA1 (see all 41):    About MalaCards
    hilar cholangiocellular carcinoma    calcaneonavicular coalition    renal carcinoma    thoracic outlet syndrome
    carcinoma    arteriovenous malformation    meningocele    metabolic disorders
    enophthalmos    goldenhar syndrome    spondylosis    spondylolisthesis
    synovial sarcoma    epithelial ovarian cancer    endometrial carcinoma    ovarian cancer
    rickets    endometrial cancer    renal cell carcinoma    ovarian endometriosis

    3 diseases from the University of Copenhagen DISEASES database for NCOA1:
    Goldenhar syndrome     Trachea leiomyoma     Synostosis

    10/17 Novoseek disease relationships for NCOA1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 44.7 22 19383905 (2), 10690532 (1), 14715875 (1), 15917309 (1) (see all 16)
    promyelocytic leukemia 29.9 1 12511612 (1)
    prostate cancer 29.5 10 19305643 (4), 19255064 (1), 15027889 (1), 12163482 (1)
    endometrial cancer 19.3 1 15284335 (1)
    endometrial carcinoma 14.8 4 14601091 (1), 14751175 (1)
    endometrial hyperplasia 13.9 6 14601091 (3)
    rhabdomyosarcoma 9.15 2 19953635 (1), 15313887 (1)
    mammary tumor 5.94 1 9541193 (1)
    inflammation 4.98 1 15231721 (1)
    necrosis 0 7 15811852 (2), 17224343 (1), 15231721 (1), 12163591 (1)

    Human Genome Epidemiology (HuGE) Navigator: NCOA1 (14 documents)

    Export disorders for NCOA1 gene to outside databases

    Publications
    for NCOA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCOA1 gene, integrated from 9 sources (see all 497):
    (articles sorted by number of sources associating them with NCOA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. (PubMed id 9575154)1, 2, 3, 9 Onate S.A....O'Malley B.W. (1998)
    2. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. (PubMed id 7481822)1, 2, 3, 9 Onate S.A.... O'Malley B.W. (1995)
    3. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. (PubMed id 10449719)1, 2, 9 Liu Z.... O'Malley B.W. (1999)
    4. A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action. (PubMed id 9223431)1, 2, 9 Hayashi Y.... Seo H. (1997)
    5. Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen- activated protein kinase pathway. (PubMed id 10660621)1, 2, 9 Rowan B.G.... O'Malley B.W. (2000)
    6. Redox-regulated recruitment of the transcriptional coactivators CREB- binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PubMed id 10594042)1, 2, 9 Carrero P....Poellinger L. (2000)
    7. Steroid receptor coactivator-1 is a histone acetyltransferase. (PubMed id 9296499)1, 2, 9 Spencer T.E....O'Malley B.W. (1997)
    8. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PubMed id 14757047)1, 2, 9 Razeto A....Becker S. (2004)
    9. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)1, 2, 9 Litterst C.M.... Pfitzner E. (2003)
    10. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. (PubMed id 9744270)1, 2, 9 Nolte R.T.... Milburn M.V. (1998)

    External Searches for NCOA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NCOA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8648 HGNC: 7668 AceView: NCOA1 Ensembl:ENSG00000084676 euGenes: HUgn8648
    ECgene: NCOA1 H-InvDB: NCOA1

    Other Databases showing NCOA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NCOA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCOA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ncoa1/

    Intellectual Property
    for NCOA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCOA1 gene:
    Search GeneIP for patents involving NCOA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     SwitchGear Promoter luciferase reporter plasmids for NCOA1
     ThermoFisher Antibody for NCOA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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