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NCOA1 Gene

protein-coding   GIFtS: 71
GCID: GC02P024719

Nuclear Receptor Coactivator 1

  See NCOA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nuclear Receptor Coactivator 11 2     bHLHe422
SRC12 3 5     Hin-2 Protein2
Class E Basic Helix-Loop-Helix Protein 742 3     PAX3/NCOA1 Fusion Protein2
Renal Carcinoma Antigen NY-REN-522 3     Steroid Receptor Coactivator-12
RIP1602 3     BHLHE743
bHLHe742 3     NCoA-13
EC 2.3.1.483 8     SRC-13
F-SRC-12     Protein Hin-23
KAT13A2     Steroid Receptor Coactivator 13

External Ids:    HGNC: 76681   Entrez Gene: 86482   Ensembl: ENSG000000846767   OMIM: 6026915   UniProtKB: Q157883   
ORGUL members:         

Export aliases for NCOA1 gene to outside databases

Previous GC identifers: GC02P024728 GC02P024899 GC02P024781 GC02P024568 GC02P024545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCOA1 Gene:
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors.
It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone
acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The
product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a
hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for NCOA1 Gene:
NCOA1 (nuclear receptor coactivator 1) is a protein-coding gene. Diseases associated with NCOA1 include trachea leiomyoma, and goldenhar syndrome. GO annotations related to this gene include chromatin binding and enzyme binding. An important paralog of this gene is NCOA3.

UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as
for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in
coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone
acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a
central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly
acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required
with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid
hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and
isoform 3

Gene Wiki entry for NCOA1 (Nuclear receptor coactivator 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCOA1 gene promoter:
         CREB   STAT5B   AP-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCOA1 promoter sequence
   Search Chromatin IP Primers for NCOA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCOA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

NCOA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCOA1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P024719:  view genomic region     (about GC identifiers)

Start:
24,714,783 bp from pter      End:
24,993,571 bp from pter
Size:
278,789 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788 (See protein sequence)
Recommended Name: Nuclear receptor coactivator 1  
Size: 1441 amino acids; 156757 Da
Subunit: Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts
with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following
IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone
acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9.
Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity.
Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6
Sequence caution: Sequence=AAA64187.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC50305.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for NCOA1 (see all 101):
1FM6 (3D)        1FM9 (3D)        1K4W (3D)        1K74 (3D)        1K7L (3D)        1KV6 (3D)    
Secondary accessions: O00150 O43792 O43793 Q13071 Q13420 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3
Alternative splicing: 3 isoforms:  Q15788-1   Q15788-2   Q15788-3   (Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation)

Explore the universe of human proteins at neXtProt for NCOA1: NX_Q15788

Explore proteomics data for NCOA1 at MOPED

Post-translational modifications: 

  • Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not
    prevent its ubiquitination and does not exert a clear effect on the stability of the protein1
  • Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different
    sites1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NCOA1 (Q15788) (see all 5)
     LEALDGFF  EKRRREQE  SHTFNCRML  NTSVYSILH 


    See NCOA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003734.3  NP_671756.1  NP_671766.1  

    ENSEMBL proteins: 
     ENSP00000385216   ENSP00000385097   ENSP00000385195   ENSP00000379197   ENSP00000320940  
     ENSP00000444039   ENSP00000288599  
    Reactome Protein details: Q15788

    NCOA1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NCOA1
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    Novus Biologicals NCOA1 Protein
    Novus Biologicals NCOA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCOA1

     
    Search eBioscience for Proteins for NCOA1 

    NCOA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NCOA1
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    Cell Signaling Technology (CST) Antibodies for NCOA1  (SRC-1)
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    Abcam antibodies for NCOA1
    Cloud-Clone Corp. Antibodies for NCOA1
    ThermoFisher Antibody for NCOA1
    LSBio Antibodies in human, mouse, rat for NCOA1

    NCOA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCOA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCOA1
    Cloud-Clone Corp. CLIAs for NCOA1
    Search eBioscience for ELISAs for NCOA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases
    bHLH: Basic helix-loop-helix proteins

    Selected InterPro protein domains (see all 10):
     IPR008955 Src1_rcpt_coact
     IPR028819 NCOA1
     IPR010011 DUF1518
     IPR014935 SRC-1
     IPR014920 Nuc_rcpt_coact_Ncoa-typ

    Graphical View of Domain Structure for InterPro Entry Q15788

    ProtoNet protein and cluster: Q15788

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB010011 Protein of unknown function DUF1518


    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
    Domain: The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity
    Domain: Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association
    with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid
    receptors in vitro
    Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Find genes that share domains with NCOA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOA1_HUMAN, Q15788
    Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional
    activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as
    for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in
    coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone
    acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a
    central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly
    acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required
    with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid
    hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and
    isoform 3
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for NCOA1:
    nuclear steroid receptor coactivator 1,possessing an intrinsic histone acetyltransferase activity,interacting with
    CREBBP and PCAF coactivating PPARG,stimulating gene expression in a hormone dependent fashion by facilitating the
    assembly of basal transcription factors into a stable preinitiation complex,enhancing ligand-dependent and
    receptor dependent cell-free transcription of chromatin,possibly involved in disruption by translocation in
    hematological malignancies

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001012RNA polymerase II regulatory region DNA binding IEA--
    GO:0001105RNA polymerase II transcription coactivator activity NAS15774904
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
         
    Find genes that share ontologies with NCOA1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NCOA1:
     Decreased viability with cispl  Increased cell death in HCC-19 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ncoa1):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     immune system  integument  nervous system  normal  renal/urinary system 
     reproductive system  skeleton 

    Find genes that share phenotypes with NCOA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NCOA1: Ncoa1tm1.1Hkaw Ncoa1tm1Bwo Ncoa1tm1Jkr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCOA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCOA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCOA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCOA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCOA1:
    hsa-let-7d-5p (MIRT051725)

    Block miRNA regulation of human, mouse, rat NCOA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCOA1 (see all 153):
    hsa-miR-631 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-130b hsa-miR-92b hsa-miR-3612 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidNCOA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NCOA1
    Predesigned siRNA for gene silencing in human, mouse, rat NCOA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCOA1

    Clone
    Products:
         
    OriGene clones in human, mouse for NCOA1 (see all 18)
    OriGene ORF clones in mouse, rat for NCOA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NCOA1 (NM_003743)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCOA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCOA1

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NCOA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCOA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCOA1_HUMAN, Q15788: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA17363140
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with NCOA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCOA1 About   (see all 36)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    RORA Activates Circadian Expression0.88
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Nuclear Receptor Activation by Vitamin-A0.57
    5Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66


    Find genes that share SuperPaths with NCOA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NCOA1 (see all 9)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway

    1 Cell Signaling Technology (CST) Pathway for NCOA1
        Chromatin Regulation / Acetylation

    Selected GeneGo (Thomson Reuters) Pathways for NCOA1 (see all 8)
        Transcription Androgen Receptor nuclear signaling
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription PPAR Pathway
    Development Ligand-dependent activation of the ESR1/AP-1 pathway

    Selected BioSystems Pathways for NCOA1 (see all 13)
        Adipogenesis
    TGF-beta Receptor Signaling Pathway
    Androgen receptor signaling pathway
    IL-6 Signaling Pathway
    Energy Metabolism

    Selected Reactome Pathways for NCOA1 (see all 10)
        Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Transcriptional activation of mitochondrial biogenesis
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


    1 Kegg Pathway  (Kegg details for NCOA1):
        Thyroid hormone signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA1: 
              Parkinson's Disease in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCOA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCOA1 (Q157881, 2, 3 ENSP000003209404) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H3Q131331, 2, 3EBI-455189,EBI-781356 MINT-7986700 MINT-7986907 MINT-7986678 MINT-7986760 MINT-7986890 MINT-7986720 MINT-7986621 MINT-7986736 MINT-7986787 MINT-7986596 MINT-7986639 MINT-7986575 MINT-7986555 MINT-7986808 I2D: score=2 
    RXRAP197931, 2, 3, ENSP000004196924EBI-455189,EBI-78598 MINT-7986700 MINT-7986678 MINT-7986848 MINT-7986760 MINT-5224970 MINT-7986720 MINT-7986865 MINT-7986787 MINT-7986736 MINT-7986639 MINT-7986822 I2D: score=5 STRING: ENSP00000419692
    PSMB9P280651, 2, 3, ENSP000003639934EBI-455189,EBI-603300 MINT-3291957 MINT-3291505 MINT-3291694 I2D: score=2 STRING: ENSP00000363993
    ENSG00000239836P280651, 2, 3EBI-455189,EBI-603300 MINT-3291957 MINT-3291505 MINT-3291694 I2D: score=2 
    ENSG00000240118P280651, 2, 3EBI-455189,EBI-603300 MINT-3291957 MINT-3291505 MINT-3291694 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000435positive regulation of transcription from RNA polymerase II promoter by galactose IDA10207113
    GO:0006351transcription, DNA-templated IDA9223431
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----
    GO:0007595lactation IEA--

    Find genes that share ontologies with NCOA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCOA1

    2 HMDB Compounds for NCOA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    Selected DrugBank Compounds for NCOA1 (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE-- --target--10592235
    (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol-- --target--10592235
    (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID-- --target--10592235
    (5BETA)-PREGNANE-3,20-DIONE-- --target--10592235
    (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid-- --target--10592235
    1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)-- --target--10592235
    1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL-- --target--10592235
    2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL-- --target--10592235
    2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL-- --target--10592235
    2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for NCOA1 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 89 557 17429319 (6), 9575154 (5), 10823935 (3), 16775354 (3) (see all 99)
    citco 85.4 2 16099843 (1), 19820207 (1)
    estrogen 77.1 74 18566116 (4), 15917309 (2), 12943741 (2), 12574227 (2) (see all 46)
    4-hydroxytamoxifen 74.9 19 9171229 (4), 14673139 (2), 8816752 (2), 14715875 (1) (see all 6)
    retinoid 72.4 31 16723356 (2), 9488734 (1), 14715875 (1), 15137909 (1) (see all 19)
    androstane 71.5 1 11256950 (1)
    tcpobop 62.4 1 15272053 (1)
    retinoic acid 61.8 45 15234273 (2), 9171239 (1), 10567404 (1), 10598588 (1) (see all 18)
    progesterone 60.9 24 11606780 (2), 15601848 (1), 15831298 (1), 12574227 (1) (see all 14)
    vitamin d 58.6 13 10406465 (2), 9440810 (1), 10773107 (1), 19255064 (1) (see all 9)



    Find genes that share compounds with NCOA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for NCOA1 gene (3 alternative transcripts): 
    NM_003743.4  NM_147223.2  NM_147233.2  

    Unigene Cluster for NCOA1:

    Nuclear receptor coactivator 1
    Hs.596314  [show with all ESTs]
    Unigene Representative Sequence: NM_147223
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496333 ENST00000406961(uc002rfk.3 uc002rfl.3) ENST00000469850
    ENST00000405141(uc010eye.3 uc002rfi.3 uc002rfj.3) ENST00000407230
    ENST00000483904 ENST00000395856 ENST00000486198 ENST00000493773 ENST00000348332
    ENST00000538539 ENST00000288599(uc010eyf.3)
    miRNA
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    hsa-miR-631 hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-130b hsa-miR-92b hsa-miR-3612 hsa-miR-34c-5p
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    Additional mRNA sequence: 

    AJ000881.1 AJ000882.1 AK226063.1 AK290019.1 BC035976.1 BC111533.1 BC111534.1 U19179.1 
    U40396.1 U59302.1 U90661.1 

    15 DOTS entries:

    DT.92436802  DT.100776908  DT.120988532  DT.65285527  DT.99947551  DT.120988525  DT.118829  DT.80100216 
    DT.120988551  DT.120988562  DT.40304905  DT.92436807  DT.95190028  DT.97765148  DT.120988470 

    Selected AceView cDNA sequences (see all 325):

    BQ884127 BQ712128 BQ023912 BM512400 AL135689 BU186862 BE856728 BM717794 
    AW772484 N33294 BU730992 BQ652096 AI306691 AA932342 BE645566 BF448032 
    CA432061 AA701439 AW295225 AL135207 BG743126 AW503958 CA397327 AI654957 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCOA1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:                    -                                                                                                           -     -               
    SP2:                    -                                                                                                           -                     
    SP3:                    -                                                                                                           -     -               
    SP4:                                                                                                                                -                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NCOA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NCOA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCCAATGA
    NCOA1 Expression
    About this image


    NCOA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    NCOA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCOA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596314

    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NCOA1: 
              Parkinson's Disease in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCOA1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncoa11 , 5 nuclear receptor coactivator 11, 5 88.94(n)1
    91.55(a)1
      12 (2.05 cM)5
    179771  NM_010881.21  NP_035011.11 
     42473635 
    chicken
    (Gallus gallus)
    Aves NCOA11 nuclear receptor coactivator 1 71.89(n)
    75.99(a)
      422016  NM_001012882.1  NP_001012900.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCOA16
    nuclear receptor coactivator 1
    68(a)
    1 ↔ 1
    GL343333.1(255204-588052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ncoa11 nuclear receptor coactivator 1 66.33(n)
    66.3(a)
      100127189  NM_001112912.1  NP_001106383.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncoa16
    nuclear receptor coactivator 1
    49(a)
    1 ↔ 1
    20(36706659-36817318) ENSDARG00000018257


    ENSEMBL Gene Tree for NCOA1 (if available)
    TreeFam Gene Tree for NCOA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCOA1 gene
    NCOA32  NCOA22  
    2 SIMAP similar genes for NCOA1 using alignment to 2 protein entries:     NCOA1_HUMAN (see all proteins):
    NCOA2    NCOA3

    Find genes that share paralogs with NCOA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCOA1 (see all 3286)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561766731,2
    C--24589908(+) AAAAA-/A/AA  
            
    TCTGT
    3 -- int11NA 2
    rs352463921,2
    C--24591405(+) ACATA-/CATATAT 3 -- int11Minor allele frequency- CA:0.00NA 2
    rs749400891,2
    C--24633690(+) ATAAC-/AATAATAT 3 -- cds10--------
    rs680731051,2
    C--24635598(+) TCTCA-/TATATA 3 -- int10--------
    rs670081501,2
    C--24644382(+) CTGCG-/ATATCA 3 -- int10--------
    rs790915811,2
    C--24649710(+) TTTATC/GCAGTC 3 -- int12Minor allele frequency- G:0.25NA 4
    rs58299291,2
    C,F--24655299(+) GGCTAT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs107164921,2
    C--24672291(+) TACTA-/TTATCA 3 -- int14Minor allele frequency- T:0.35NS NA CSA 98
    rs671779391,2
    C--24691434(+) TCACC-/TTGTCA 3 -- int10--------
    rs2001868791,2
    --24724333(+) TCTCT-/CTTTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for NCOA1 (24714783 - 24964783 bp, first 250kb of NCOA1)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NCOA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719821CNV Deletion23290073
    esv1430695CNV Deletion17803354
    nsv2643CNV Insertion18451855
    nsv528864CNV Loss19592680
    nsv873741CNV Loss21882294
    nsv516493CNV Gain19592680

    Human Gene Mutation Database (HGMD): NCOA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCOA1
    DNA2.0 Custom Variant and Variant Library Synthesis for NCOA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602691    OMIM disorders: --

    UniProtKB/Swiss-Prot: NCOA1_HUMAN, Q15788
  • Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation
    t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the
    C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most
    common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children

  • 2 diseases for NCOA1:    
    About MalaCards
    trachea leiomyoma    goldenhar syndrome

    3 diseases from the University of Copenhagen DISEASES database for NCOA1:
    Goldenhar syndrome     Trachea leiomyoma     Synostosis

    Find genes that share disorders with NCOA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NCOA1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 44.7 22 19383905 (2), 10690532 (1), 14715875 (1), 15917309 (1) (see all 16)
    promyelocytic leukemia 29.9 1 12511612 (1)
    prostate cancer 29.5 10 19305643 (4), 19255064 (1), 15027889 (1), 12163482 (1)
    endometrial cancer 19.3 1 15284335 (1)
    endometrial carcinoma 14.8 4 14601091 (1), 14751175 (1)
    endometrial hyperplasia 13.9 6 14601091 (3)
    rhabdomyosarcoma 9.15 2 19953635 (1), 15313887 (1)
    mammary tumor 5.94 1 9541193 (1)
    inflammation 4.98 1 15231721 (1)
    necrosis 0 7 15811852 (2), 17224343 (1), 15231721 (1), 12163591 (1)

    Genetic Association Database (GAD): NCOA1
    Human Genome Epidemiology (HuGE) Navigator: NCOA1 (14 documents)

    Export disorders for NCOA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NCOA1 gene, integrated from 10 sources (see all 508):
    (articles sorted by number of sources associating them with NCOA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. (PubMed id 9575154)1, 2, 3, 9 Onate S.A.... O'Malley B.W. (J. Biol. Chem. 1998)
    2. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. (PubMed id 7481822)1, 2, 3, 9 Onate S.A.... O'Malley B.W. (Science 1995)
    3. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. (PubMed id 10449719)1, 2, 9 Liu Z.... O'Malley B.W. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action. (PubMed id 9223431)1, 2, 9 Hayashi Y.... Seo H. (Biochem. Biophys. Res. Commun. 1997)
    5. Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen- activated protein kinase pathway. (PubMed id 10660621)1, 2, 9 Rowan B.G.... O'Malley B.W. (J. Biol. Chem. 2000)
    6. Redox-regulated recruitment of the transcriptional coactivators CREB- binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PubMed id 10594042)1, 2, 9 Carrero P....Poellinger L. (Mol. Cell. Biol. 2000)
    7. Steroid receptor coactivator-1 is a histone acetyltransferase. (PubMed id 9296499)1, 2, 9 Spencer T.E....O'Malley B.W. (Nature 1997)
    8. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PubMed id 14757047)1, 2, 9 Razeto A....Becker S. (J. Mol. Biol. 2004)
    9. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)1, 2, 9 Litterst C.M.... Pfitzner E. (J. Biol. Chem. 2003)
    10. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. (PubMed id 9744270)1, 2, 9 Nolte R.T.... Milburn M.V. (Nature 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8648 HGNC: 7668 AceView: NCOA1 Ensembl:ENSG00000084676 euGenes: HUgn8648
    ECgene: NCOA1 Kegg: 8648 H-InvDB: NCOA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NCOA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCOA1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ncoa1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCOA1 gene:
    Search GeneIP for patents involving NCOA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCOA1
     LSBio Antibodies in human, mouse, rat for NCOA1
    Customized transgenic rodents for:
     Humanization
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     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NCOA1
      Search eBioscience for proteins for NCOA1
      Search eBioscience for elisas for NCOA1
      eBioscience FlowRNA Probe Sets
           
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