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Aliases for NCOA1 Gene

Aliases for NCOA1 Gene

  • Nuclear Receptor Coactivator 1 2 3
  • Class E Basic Helix-Loop-Helix Protein 74 3 4
  • Renal Carcinoma Antigen NY-REN-52 3 4
  • EC 2.3.1.48 4 63
  • BHLHe74 3 4
  • RIP160 3 4
  • SRC1 3 4
  • Steroid Receptor Coactivator-1 3
  • Steroid Receptor Coactivator 1 4
  • PAX3/NCOA1 Fusion Protein 3
  • Hin-2 Protein 3
  • Protein Hin-2 4
  • BHLHe42 3
  • F-SRC-1 3
  • KAT13A 3
  • NCoA-1 4
  • SRC-1 4

External Ids for NCOA1 Gene

Previous GeneCards Identifiers for NCOA1 Gene

  • GC02P024728
  • GC02P024899
  • GC02P024781
  • GC02P024719
  • GC02P024568

Summaries for NCOA1 Gene

Entrez Gene Summary for NCOA1 Gene

  • The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCOA1 Gene

NCOA1 (Nuclear Receptor Coactivator 1) is a Protein Coding gene. Diseases associated with NCOA1 include rhabdomyosarcoma. Among its related pathways are Developmental Biology and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include chromatin binding and transcription factor binding. An important paralog of this gene is NCOA2.

UniProtKB/Swiss-Prot for NCOA1 Gene

  • Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Gene Wiki entry for NCOA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA1 Gene

Genomics for NCOA1 Gene

Regulatory Elements for NCOA1 Gene

Genomic Location for NCOA1 Gene

Chromosome:
2
Start:
24,491,914 bp from pter
End:
24,770,702 bp from pter
Size:
278,789 bases
Orientation:
Plus strand

Genomic View for NCOA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA1 Gene

Proteins for NCOA1 Gene

  • Protein details for NCOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15788-NCOA1_HUMAN
    Recommended name:
    Nuclear receptor coactivator 1
    Protein Accession:
    Q15788
    Secondary Accessions:
    • O00150
    • O43792
    • O43793
    • Q13071
    • Q13420
    • Q2T9G5
    • Q53SX3
    • Q6GVI5
    • Q7KYV3

    Protein attributes for NCOA1 Gene

    Size:
    1441 amino acids
    Molecular mass:
    156757 Da
    Quaternary structure:
    • Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA. Interacts with TRIP4. Interacts with NR4A3 (By similarity).
    SequenceCaution:
    • Sequence=AAA64187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC50305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOA1 Gene

    Alternative splice isoforms for NCOA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOA1 Gene

Proteomics data for NCOA1 Gene at MOPED

Selected DME Specific Peptides for NCOA1 Gene

Post-translational modifications for NCOA1 Gene

  • Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
  • Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCOA1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCOA1 (SRC-1)

Domains & Families for NCOA1 Gene

Suggested Antigen Peptide Sequences for NCOA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15788

UniProtKB/Swiss-Prot:

NCOA1_HUMAN :
  • The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
Domain:
  • The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity
  • Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the SRC/p160 nuclear receptor coactivator family.
genes like me logo Genes that share domains with NCOA1: view

Function for NCOA1 Gene

Molecular function for NCOA1 Gene

GENATLAS Biochemistry:
nuclear steroid receptor coactivator 1,possessing an intrinsic histone acetyltransferase activity,interacting with CREBBP and PCAF coactivating PPARG,stimulating gene expression in a hormone dependent fashion by facilitating the assembly of basal transcription factors into a stable preinitiation complex,enhancing ligand-dependent and receptor dependent cell-free transcription of chromatin,possibly involved in disruption by translocation in hematological malignancies
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Enzyme Numbers (IUBMB) for NCOA1 Gene

Gene Ontology (GO) - Molecular Function for NCOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001012 RNA polymerase II regulatory region DNA binding IEA --
GO:0001105 RNA polymerase II transcription coactivator activity NAS 15774904
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
genes like me logo Genes that share ontologies with NCOA1: view
genes like me logo Genes that share phenotypes with NCOA1: view

Animal Models for NCOA1 Gene

MGI Knock Outs for NCOA1:

Animal Model Products

miRNA for NCOA1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NCOA1 Gene

Localization for NCOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA1 Gene COMPARTMENTS Subcellular localization image for NCOA1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NCOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 15831516
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with NCOA1: view

Pathways & Interactions for NCOA1 Gene

genes like me logo Genes that share pathways with NCOA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for NCOA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NCOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose IDA 10207113
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IDA 9223431
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with NCOA1: view

Drugs & Compounds for NCOA1 Gene

(55) Drugs for NCOA1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bicalutamide Approved Pharma Androgen receptor antagonist, Non-steroidal androgen receptor antagonist 158
chenodeoxycholic acid Approved Pharma Antagonist 23
Clotrimazole Approved Pharma Channel blocker Cytochrome P450 inhibitor; antifungal 24
deoxycholic acid Approved Pharma Antagonist 40
Diethylstilbestrol Approved Pharma Antagonist 5

(13) Additional Compounds for NCOA1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
1,25 DIHYDROXY VITAMIN D3
androstane
butyrate
Fatty acid
genes like me logo Genes that share compounds with NCOA1: view

Transcripts for NCOA1 Gene

Unigene Clusters for NCOA1 Gene

Nuclear receptor coactivator 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for NCOA1 Gene

GeneLoc Exon Structure for
NCOA1
ECgene alternative splicing isoforms for
NCOA1

Expression for NCOA1 Gene

mRNA expression in normal human tissues for NCOA1 Gene

Protein differential expression in normal tissues from HIPED for NCOA1 Gene

This gene is overexpressed in Stomach (33.2), Hair follicle (20.3), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA1 Gene



SOURCE GeneReport for Unigene cluster for NCOA1 Gene Hs.596314

mRNA Expression by UniProt/SwissProt for NCOA1 Gene

Q15788-NCOA1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NCOA1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NCOA1 Gene

Orthologs for NCOA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCOA1 35
  • 93.62 (n)
  • 95.87 (a)
NCOA1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA1 35
  • 94.06 (n)
  • 96.14 (a)
NCOA1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa1 35
  • 88.94 (n)
  • 91.55 (a)
Ncoa1 16
Ncoa1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCOA1 35
  • 99.72 (n)
  • 99.93 (a)
NCOA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa1 35
  • 89.42 (n)
  • 92.47 (a)
oppossum
(Monodelphis domestica)
Mammalia NCOA1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA1 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA1 35
  • 71.89 (n)
  • 75.99 (a)
NCOA1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa1 35
  • 66.33 (n)
  • 66.3 (a)
zebrafish
(Danio rerio)
Actinopterygii ncoa1 36
  • 49 (a)
OneToOne
Species with no ortholog for NCOA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA1 Gene

ENSEMBL:
Gene Tree for NCOA1 (if available)
TreeFam:
Gene Tree for NCOA1 (if available)

Paralogs for NCOA1 Gene

Paralogs for NCOA1 Gene

(2) SIMAP similar genes for NCOA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NCOA1: view

Variants for NCOA1 Gene

Sequence variations from dbSNP and Humsavar for NCOA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13883 -- 24,742,028(+) TGCTT(A/C)TACCA missense, reference
rs15442 -- 24,768,988(+) ATGGA(C/T)TTAAA utr-variant-3-prime
rs719189 -- 24,652,909(-) ACAGT(G/T)GTATT intron-variant
rs723246 -- 24,508,810(+) AGACA(A/G)CTTTA intron-variant
rs744077 -- 24,711,945(-) ACATA(C/T)GATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA1 Gene

Variant ID Type Subtype PubMed ID
nsv516493 CNV Gain 19592680
nsv873741 CNV Loss 21882294
nsv528864 CNV Loss 19592680
esv2719821 CNV Deletion 23290073
nsv2643 CNV Insertion 18451855
esv1430695 CNV Deletion 17803354

Variation tolerance for NCOA1 Gene

Residual Variation Intolerance Score: .98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA1 Gene

HapMap Linkage Disequilibrium report
NCOA1
Human Gene Mutation Database (HGMD)
NCOA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA1 Gene

Disorders for NCOA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCOA1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma
- elite association
Search NCOA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NCOA1_HUMAN
  • Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.

Relevant External Links for NCOA1

Genetic Association Database (GAD)
NCOA1
Human Genome Epidemiology (HuGE) Navigator
NCOA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA1
genes like me logo Genes that share disorders with NCOA1: view

No data available for Genatlas for NCOA1 Gene

Publications for NCOA1 Gene

  1. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. (PMID: 9575154) Onate S.A. … O'Malley B.W. (J. Biol. Chem. 1998) 2 23 67
  2. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. (PMID: 7481822) Onate S.A. … O'Malley B.W. (Science 1995) 2 23 67
  3. The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors. (PMID: 19652917) Chiang S. … He R. (Mol. Cell. Biochem. 2010) 23 67
  4. A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3. (PMID: 19820207) Chen T. … Wang H. (J. Pharmacol. Exp. Ther. 2010) 23 67
  5. Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium. (PMID: 20155281) Suzuki A. … Shiozawa T. (Virchows Arch. 2010) 23 67

Products for NCOA1 Gene

Sources for NCOA1 Gene

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