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NCMAP Gene

protein-coding   GIFtS: 31
GCID: GC01P024883

Noncompact Myelin Associated Protein

(Previous name: chromosome 1 open reading frame 130)
(Previous symbol: C1orf130)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Noncompact Myelin Associated Protein1 2
C1orf1301 2 3
Myelin Protein Of 11 KDa1 2 3
MP112 3
Chromosome 1 Open Reading Frame 1301
Noncompact Myelin-Associated Protein2

External Ids:    HGNC: 293321   Entrez Gene: 4007462   Ensembl: ENSG000001844547   UniProtKB: Q5T1S83   

Export aliases for NCMAP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NCMAP Gene:
NCMAP (noncompact myelin associated protein) is a protein-coding gene. GO annotations related to this gene include structural constituent of myelin sheath.

UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8
Function: Plays a role in myelin formation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NCMAP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NCMAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCMAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

NCMAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCMAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024883:  view genomic region     (about GC identifiers)

Start:
24,882,602 bp from pter      End:
24,935,819 bp from pter
Size:
53,218 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8 (See protein sequence)
Recommended Name: Noncompact myelin-associated protein  
Size: 102 amino acids; 11082 Da
Secondary accessions: A0PK04 B2RV34

Explore the universe of human proteins at neXtProt for NCMAP: NX_Q5T1S8

Explore proteomics data for NCMAP at MOPED

Post-translational modifications: 

  • Glycosylated (By similarity)1
  • Modification sites at neXtProt

  • See NCMAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010980.1  
    ENSEMBL proteins: 
     ENSP00000363513  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5T1S8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCMAP_HUMAN, Q5T1S8
    Function: Plays a role in myelin formation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019911structural constituent of myelin sheath ISS--
         
    Find genes that share ontologies with NCMAP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCMAP:
     Decreased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NCMAP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCMAP_HUMAN, Q5T1S8: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized mainly in
    the Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ISS--
    GO:0033270paranode region of axon ISS--
    GO:0043220Schmidt-Lanterman incisure ISS--

    Find genes that share ontologies with NCMAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCMAP
    Interactions:

        Search GeneGlobe Interaction Network for NCMAP

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031643positive regulation of myelination ISS--
    GO:0032290peripheral nervous system myelin formation ISS--

    Find genes that share ontologies with NCMAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCMAP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCMAP gene: 
    NM_001010980.4  

    Unigene Cluster for NCMAP:

    Noncompact myelin associated protein
    Hs.200253  [show with all ESTs]
    Unigene Representative Sequence: NM_001010980
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374392(uc001bjk.2) ENST00000486262
    miRNA
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    Additional mRNA sequence: 

    AK124519.1 BC127785.1 BC147014.1 BC147015.1 

    5 DOTS entries:

    DT.91750282  DT.99962170  DT.75169071  DT.40110030  DT.95291098 

    20 AceView cDNA sequences:

    CB177272 BX118476 AA614595 AK124519 BQ718222 CB068372 CD109653 CF593429 
    BC050474 AW276618 CB961010 BI762836 CD516894 BI052641 BI052081 AL543301 
    R26813 BE165683 R26010 BE165686 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NCMAP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    


    ECgene alternative splicing isoforms for NCMAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCMAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCMAP Expression
    About this image


    NCMAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Endochondral Facial Bones
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Interzone Cells Stylopod Synovial Joint
             Zeugopod
     
     Lung (Respiratory System)
             Trachea
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Cartilage (Muscoskeletal System)
             Interzone Cells Stylopod Synovial Joint
    NCMAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCMAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200253
        Custom PCR Arrays for NCMAP
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for NCMAP gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncmap1 , 5 RIKEN cDNA A330049M08 gene5
    noncompact myelin associated protein1
    84.67(n)1
    80(a)1
      4 (67.47 cM)5
    2308221  NM_181047.11  NP_851390.11 
     1353695765 


    ENSEMBL Gene Tree for NCMAP (if available)
    TreeFam Gene Tree for NCMAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCMAP (see all 1383)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866759261,2
    --24880579(+) GTTATG/TGGAGG 1 -- us2k10--------
    rs120635271,2
    C,F,A--24880589(+) GGCTGG/ATGCAA 1 -- us2k17Minor allele frequency- A:0.25WA NA CSA EA 366
    rs1917359891,2
    --24880815(+) TTCTCC/GCACTT 1 -- us2k10--------
    rs679923511,2
    C,F--24880906(+) AGAAAC/AAGTCT 1 -- us2k16Minor allele frequency- A:0.22WA NA EA 364
    rs1817929201,2
    --24880913(+) GTCTCA/CGAAAC 1 -- us2k10--------
    rs1396442911,2
    --24880932(+) TCTTGC/TGAATA 1 -- us2k10--------
    rs1497671891,2
    --24880951(+) TGGAGA/CCAGGA 1 -- us2k10--------
    rs681830001,2
    C,F--24880973(+) GACCAT/CGCACT 1 -- us2k18Minor allele frequency- C:0.35WA NA CSA EA 367
    rs1872256401,2
    --24880980(+) CACTGG/TGGGCT 1 -- us2k10--------
    rs66855611,2
    C,F--24881037(+) AGTGGG/CCCCCC 1 -- us2k1 tfbs34Minor allele frequency- C:0.43WA NA CSA 7

    HapMap Linkage Disequilibrium report for NCMAP (24882602 - 24935819 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NCMAP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCMAP
    DNA2.0 Custom Variant and Variant Library Synthesis for NCMAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCMAP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NCMAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. (PubMed id 18650334)1, 3 Ryu E.J....Milbrandt J. (J. Neurosci. 2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400746 HGNC: 29332 AceView: LOC400746 Ensembl:ENSG00000184454 euGenes: HUgn400746
    ECgene: NCMAP H-InvDB: NCMAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCMAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCMAP gene:
    Search GeneIP for patents involving NCMAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NCMAP
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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