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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCMAP Gene

protein-coding   GIFtS: 34
GCID: GC01P024883

noncompact myelin associated protein

(Previous name: chromosome 1 open reading frame 130 )
(Previous symbol: C1orf130)
  Search for NCMAP
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NCMAP    

Aliases
for NCMAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Noncompact Myelin Associated Protein1 2     FLJ425281
C1orf1301 2 3     Chromosome 1 Open Reading Frame 1301
MP111 2 3     Noncompact Myelin-Associated Protein2
Myelin Protein Of 11 KDa2 3     

External Ids:    HGNC: 293321   Entrez Gene: 4007462   Ensembl: ENSG000001844547   UniProtKB: Q5T1S83   

Export aliases for NCMAP gene to outside databases


Summaries
for NCMAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8
Function: Plays a role in myelin formation (By similarity)




Genomic Views
for NCMAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NCMAP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NCMAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCMAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

NCMAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCMAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024883:  view genomic region     (about GC identifiers)

Start:
 24,882,602 bp from pter      End:
 24,935,819 bp from pter
Size:
 53,218 bases      Orientation:
 plus strand

Proteins
for NCMAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8 (See protein sequence)
Recommended Name: Noncompact myelin-associated protein  
Size: 102 amino acids; 11082 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized mainly in the
Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin (By similarity)
Secondary accessions: A0PK04 B2RV34

Explore the universe of human proteins at neXtProt for NCMAP: NX_Q5T1S8

Post-translational modifications:

  • Glycosylated (By similarity)1
  • View neXtProt modification sites for NX_Q5T1S8

    • NCMAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001010980.1  
    ENSEMBL proteins: 
     ENSP00000363513  

    Human Recombinant Protein Products: 
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    Uscn Proteins for NCMAP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ISS--
    GO:0016021integral to membrane ----
    GO:0033270paranode region of axon ISS--
    GO:0043220Schmidt-Lanterman incisure ISS--


    NCMAP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NCMAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T1S8


    Function
    for NCMAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8
    Function: Plays a role in myelin formation (By similarity)

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019911structural constituent of myelin sheath ISS--


    NCMAP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NCMAP:
     Decreased number of cells in m 


    Pathways & Interactions
    for NCMAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCMAP

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031643positive regulation of myelination ISS--
    GO:0032290peripheral nervous system myelin formation ISS--


    NCMAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCMAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCMAP
    Search CenterWatch for drugs/clinical trials and news about NCMAP 

    Transcripts
    for NCMAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCMAP gene: 
    NM_001010980.4  

    Unigene Cluster for NCMAP:

    Noncompact myelin associated protein
    Hs.200253  [show with all ESTs]
    Unigene Representative Sequence: NM_001010980
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374392(uc001bjk.2) ENST00000486262

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK124519.1 BC127785.1 BC147014.1 BC147015.1 

    5 DOTS entries:

    DT.91750282  DT.99962170  DT.75169071  DT.40110030  DT.95291098 

    20 AceView cDNA sequences:

    CB177272 BX118476 CD109653 AK124519 AA614595 BC050474 CB068372 AW276618 
    CB961010 BQ718222 CF593429 BI052641 CD516894 BI762836 BI052081 AL543301 
    R26813 BE165683 R26010 BE165686 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NCMAP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    


    ECgene alternative splicing isoforms for NCMAP

    Expression
    for NCMAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    NCMAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbStylopod Synovial JointInterzone CellsCartilage
    BoneAutopod Long BoneBone
    BoneCaudal Endochondral BonesBone
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Growth PlateBone
    LimbStylopodLimb
    LimbStylopod Synovial JointLimb
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NCMAP Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.200253
        SABiosciences Custom PCR Arrays for NCMAP
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCMAP

    Orthologs
    for NCMAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NCMAP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ncmap1 , 5 RIKEN cDNA A330049M08 gene5
    noncompact myelin associated protein1    		 84.33(n)1
    80(a)1    		   4 (67.47 cM)5
    2308221  NM_001168498.11  NP_001161970.11 
     1353695765 
    chicken
    (Gallus gallus)    		 Aves C23H1orf1301 chromosome 23 open reading frame, human C1orf130 65.96(n)
    60(a)    		   419596  XM_417742.3  XP_417742.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C1orf1306
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343464.1(165908-167869)


    ENSEMBL Gene Tree for NCMAP (if available)
    TreeFam Gene Tree for NCMAP (if available) 

    Paralogs
    for NCMAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NCMAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1213 NCBI SNPs in NCMAP are shown (see all 1213)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1866759261,2
    		--24880579(+) GTTATG/TGGAGG 1 -- us2k10--------
    rs120635271,2
    		C,F,A,--24880589(+) GGCTGG/ATGCAA 1 -- us2k17Minor allele frequency- A:0.25WA NA CSA EA 366
    rs1917359891,2
    		--24880815(+) TTCTCC/GCACTT 1 -- us2k10--------
    rs679923511,2
    		C,F,--24880906(+) AGAAAC/AAGTCT 1 -- us2k16Minor allele frequency- A:0.22WA NA EA 364
    rs1817929201,2
    		--24880913(+) GTCTCA/CGAAAC 1 -- us2k10--------
    rs1396442911,2
    		--24880932(+) TCTTGC/TGAATA 1 -- us2k10--------
    rs1497671891,2
    		--24880951(+) TGGAGA/CCAGGA 1 -- us2k10--------
    rs681830001,2
    		C,F,--24880973(+) GACCAT/CGCACT 1 -- us2k18Minor allele frequency- C:0.35WA NA CSA EA 367
    rs1872256401,2
    		--24880980(+) CACTGG/TGGGCT 1 -- us2k10--------
    rs66855611,2
    		C,F,--24881037(+) AGTGGG/CCCCCC 1 -- us2k1 tfbs34Minor allele frequency- C:0.43WA NA CSA 7

    HapMap Linkage Disequilibrium report for NCMAP (24882602 - 24935819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NCMAP: --

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    Disorders / Diseases
    for NCMAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for NCMAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCMAP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NCMAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of peripheral nerve expression profiles iden tifies a novel myelin glycoprotein, MP11. (PubMed id 18650334)1, 3 Ryu E.J....Milbrandt J. (2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NCMAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NCMAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400746 HGNC: 29332 AceView: LOC400746 Ensembl:ENSG00000184454 euGenes: HUgn400746
    ECgene: NCMAP H-InvDB: NCMAP

    Other Databases showing NCMAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NCMAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCMAP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NCMAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCMAP gene:
    Search GeneIP for patents involving NCMAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NCMAP gene

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    Advanced Cell Diagnostics
    About This Section

     
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