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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCMAP Gene

protein-coding   GIFtS: 33
GCID: GC01P024883

Noncompact Myelin Associated Protein

(Previous name: chromosome 1 open reading frame 130)
(Previous symbol: C1orf130)
  Search for NCMAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Noncompact Myelin Associated Protein1 2
C1orf1301 2 3
Myelin Protein Of 11 KDa1 2 3
MP112 3
Chromosome 1 Open Reading Frame 1301
Noncompact Myelin-Associated Protein2

External Ids:    HGNC: 293321   Entrez Gene: 4007462   Ensembl: ENSG000001844547   UniProtKB: Q5T1S83   

Export aliases for NCMAP gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NCMAP Gene: 
NCMAP (noncompact myelin associated protein) is a protein-coding gene. GO annotations related to this gene include structural constituent of myelin sheath.

UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8
Function: Plays a role in myelin formation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NCMAP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NCMAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCMAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

NCMAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCMAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024883:  view genomic region     (about GC identifiers)

Start:
24,882,602 bp from pter      End:
24,935,819 bp from pter
Size:
53,218 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCMAP_HUMAN, Q5T1S8 (See protein sequence)
Recommended Name: Noncompact myelin-associated protein  
Size: 102 amino acids; 11082 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized mainly in
the Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin (By similarity)
Secondary accessions: A0PK04 B2RV34

Explore the universe of human proteins at neXtProt for NCMAP: NX_Q5T1S8

Post-translational modifications:

  • UniProtKB: Glycosylated (By similarity)
  • View neXtProt modification sites for NX_Q5T1S8

  • NCMAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001010980.1  
    ENSEMBL proteins: 
     ENSP00000363513  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ISS--
    GO:0033270paranode region of axon ISS--
    GO:0043220Schmidt-Lanterman incisure ISS--

    NCMAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T1S8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCMAP_HUMAN, Q5T1S8
    Function: Plays a role in myelin formation (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019911structural constituent of myelin sheath ISS--
         
    NCMAP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCMAP:
     Decreased number of cells in m 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCMAP

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031643positive regulation of myelination ISS--
    GO:0032290peripheral nervous system myelin formation ISS--

    NCMAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about NCMAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NCMAP gene: 
    NM_001010980.4  

    Unigene Cluster for NCMAP:

    Noncompact myelin associated protein
    Hs.200253  [show with all ESTs]
    Unigene Representative Sequence: NM_001010980
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374392(uc001bjk.2) ENST00000486262
    miRNA
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    Additional mRNA sequence: 

    AK124519.1 BC127785.1 BC147014.1 BC147015.1 

    5 DOTS entries:

    DT.91750282  DT.99962170  DT.75169071  DT.40110030  DT.95291098 

    20 AceView cDNA sequences:

    CB177272 BX118476 AW276618 CB961010 AK124519 CF593429 BQ718222 CD109653 
    BC050474 CB068372 AA614595 BI762836 CD516894 BI052641 BI052081 R26813 
    AL543301 BE165683 R26010 BE165686 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NCMAP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    


    ECgene alternative splicing isoforms for NCMAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    NCMAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Endochondral Facial Bones
             sensory organ/ear/inner ear   
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Interzone Cells Stylopod Synovial Joint
             Zeugopod
             limb/hindlimb/leg   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Interzone Cells Stylopod Synovial Joint
             sensory organ/ear/inner ear   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/chondrocranium   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    SOURCE GeneReport for Unigene cluster: Hs.200253
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCMAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NCMAP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncmap1 , 5 RIKEN cDNA A330049M08 gene5
    noncompact myelin associated protein1
    84.33(n)1
    80(a)1
      4 (67.47 cM)5
    2308221  NM_001168498.11  NP_001161970.11 
     1353695765 
    chicken
    (Gallus gallus)
    Aves C23H1orf1301 chromosome 23 open reading frame, human C1orf130 65.96(n)
    60(a)
      419596  XM_417742.3  XP_417742.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCMAP6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343464.1(165908-167869)


    ENSEMBL Gene Tree for NCMAP (if available)
    TreeFam Gene Tree for NCMAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1383 SNPs in NCMAP are shown (see all 1383)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866759261,2
    --24880579(+) GTTATG/TGGAGG 1 -- us2k10--------
    rs120635271,2
    C,F,A--24880589(+) GGCTGG/ATGCAA 1 -- us2k17Minor allele frequency- A:0.25WA NA CSA EA 366
    rs1917359891,2
    --24880815(+) TTCTCC/GCACTT 1 -- us2k10--------
    rs679923511,2
    C,F--24880906(+) AGAAAC/AAGTCT 1 -- us2k16Minor allele frequency- A:0.22WA NA EA 364
    rs1817929201,2
    --24880913(+) GTCTCA/CGAAAC 1 -- us2k10--------
    rs1396442911,2
    --24880932(+) TCTTGC/TGAATA 1 -- us2k10--------
    rs1497671891,2
    --24880951(+) TGGAGA/CCAGGA 1 -- us2k10--------
    rs681830001,2
    C,F--24880973(+) GACCAT/CGCACT 1 -- us2k18Minor allele frequency- C:0.35WA NA CSA EA 367
    rs1872256401,2
    --24880980(+) CACTGG/TGGGCT 1 -- us2k10--------
    rs66855611,2
    C,F--24881037(+) AGTGGG/CCCCCC 1 -- us2k1 tfbs34Minor allele frequency- C:0.43WA NA CSA 7

    HapMap Linkage Disequilibrium report for NCMAP (24882602 - 24935819 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NCMAP: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCMAP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NCMAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of peripheral nerve expression profiles iden tifies a novel myelin glycoprotein, MP11. (PubMed id 18650334)1, 3 Ryu E.J....Milbrandt J. (2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400746 HGNC: 29332 AceView: LOC400746 Ensembl:ENSG00000184454 euGenes: HUgn400746
    ECgene: NCMAP H-InvDB: NCMAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCMAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCMAP gene:
    Search GeneIP for patents involving NCMAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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