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Aliases for NCLN Gene

Aliases for NCLN Gene

  • Nicalin 2 3 5
  • Nicastrin-Like Protein 2 3 4
  • Nicalin Homolog (Zebrafish) 2
  • Nicalin Homolog 3
  • NET59 3

External Ids for NCLN Gene

Previous GeneCards Identifiers for NCLN Gene

  • GC19P003139
  • GC19P002952

Summaries for NCLN Gene

GeneCards Summary for NCLN Gene

NCLN (Nicalin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NCLN Gene

  • May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

Gene Wiki entry for NCLN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCLN Gene

Genomics for NCLN Gene

Regulatory Elements for NCLN Gene

Enhancers for NCLN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCLN on UCSC Golden Path with GeneCards custom track

Promoters for NCLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCLN on UCSC Golden Path with GeneCards custom track

Genomic Location for NCLN Gene

3,185,563 bp from pter
3,209,575 bp from pter
24,013 bases
Plus strand

Genomic View for NCLN Gene

Genes around NCLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCLN Gene

Proteins for NCLN Gene

  • Protein details for NCLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D6W613
    • O75252
    • Q6FI60
    • Q6ZMB7
    • Q8TAT7
    • Q96H48
    • Q96IS7
    • Q9BQH9
    • Q9BTX4
    • Q9NPP2

    Protein attributes for NCLN Gene

    563 amino acids
    Molecular mass:
    62974 Da
    Quaternary structure:
    • Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.
    • Sequence=AAH03076.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH25926.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66502.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCLN Gene


neXtProt entry for NCLN Gene

Proteomics data for NCLN Gene at MOPED

Post-translational modifications for NCLN Gene

  • Ubiquitination at Lys 99, Lys 471, and Lys 491
  • Glycosylation at Asn 241 and Asn 428
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NCLN Gene

Domains & Families for NCLN Gene

Protein Domains for NCLN Gene


Suggested Antigen Peptide Sequences for NCLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nicastrin family.
  • Belongs to the nicastrin family.
genes like me logo Genes that share domains with NCLN: view

No data available for Gene Families for NCLN Gene

Function for NCLN Gene

Molecular function for NCLN Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
genes like me logo Genes that share phenotypes with NCLN: view

Animal Model Products

miRNA for NCLN Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCLN Gene

Localization for NCLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCLN Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NCLN Gene COMPARTMENTS Subcellular localization image for NCLN gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NCLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCLN: view

Pathways & Interactions for NCLN Gene

SuperPathways for NCLN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCLN Gene


No data available for Pathways by source and SIGNOR curated interactions for NCLN Gene

Drugs & Compounds for NCLN Gene

No Compound Related Data Available

Transcripts for NCLN Gene

Unigene Clusters for NCLN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCLN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: - -

ExUns: 18

Relevant External Links for NCLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCLN Gene

mRNA expression in normal human tissues for NCLN Gene

Protein differential expression in normal tissues from HIPED for NCLN Gene

This gene is overexpressed in Neutrophil (7.6) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCLN Gene

SOURCE GeneReport for Unigene cluster for NCLN Gene Hs.657032

mRNA Expression by UniProt/SwissProt for NCLN Gene

Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
genes like me logo Genes that share expression patterns with NCLN: view

Protein tissue co-expression partners for NCLN Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NCLN Gene

Orthologs for NCLN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCLN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NCLN 35
  • 89.09 (n)
  • 94.31 (a)
  • 94 (a)
(Canis familiaris)
Mammalia NCLN 35
  • 90.29 (n)
  • 95.2 (a)
  • 95 (a)
(Mus musculus)
Mammalia Ncln 35
  • 87.15 (n)
  • 93.43 (a)
Ncln 16
Ncln 36
  • 93 (a)
(Pan troglodytes)
Mammalia NCLN 35
  • 98.64 (n)
  • 99.64 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ncln 35
  • 87.21 (n)
  • 93.07 (a)
(Monodelphis domestica)
Mammalia NCLN 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia NCLN 36
  • 85 (a)
(Gallus gallus)
Aves NCLN 35
  • 73.5 (n)
  • 79.14 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia NCLN 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncln 35
  • 72.86 (n)
  • 81.96 (a)
Str.1209 35
(Danio rerio)
Actinopterygii ncl1 35
  • 73.65 (n)
  • 76.68 (a)
wufb07e09 35
ncl1 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002549 35
  • 53.46 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4972 35
  • 48.2 (n)
  • 38.59 (a)
CG4972 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea nra-2 35
  • 41.38 (n)
  • 32.92 (a)
nra-2 36
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G44330 35
  • 44.56 (n)
  • 37.15 (a)
(Oryza sativa)
Liliopsida Os08g0102100 35
  • 46.09 (n)
  • 39.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10535 36
  • 36 (a)
Species with no ortholog for NCLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCLN Gene

Gene Tree for NCLN (if available)
Gene Tree for NCLN (if available)

Paralogs for NCLN Gene

No data available for Paralogs for NCLN Gene

Variants for NCLN Gene

Sequence variations from dbSNP and Humsavar for NCLN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2288949 - 3,207,648(+) CTACA(A/G)GACCG reference, missense
rs11671067 - 3,198,843(+) GGAGA(C/G)GACCT reference, missense
rs12976885 -- 3,199,767(+) acaat(C/T)tcggc intron-variant
rs12976887 -- 3,199,769(+) aatct(C/G)ggctc intron-variant
rs12976902 -- 3,199,785(+) aacct(C/T)tgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCLN Gene

Variant ID Type Subtype PubMed ID
nsv910697 CNV Loss 21882294
nsv509716 CNV Insertion 20534489
dgv3648n71 CNV Loss 21882294
dgv3649n71 CNV Loss 21882294
nsv910720 CNV Loss 21882294
nsv910721 CNV Loss 21882294

Variation tolerance for NCLN Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NCLN Gene

Disorders for NCLN Gene

Relevant External Links for NCLN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NCLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCLN Gene

Publications for NCLN Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PMID: 17261586) Haffner C. … Haass C. (J. Biol. Chem. 2007) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NCLN Gene

Sources for NCLN Gene