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Aliases for NCLN Gene

Aliases for NCLN Gene

  • Nicalin 2 3
  • Nicastrin-Like Protein 2 3 4
  • Nicalin Homolog (Zebrafish) 2
  • Nicalin Homolog (Zebrefish) 3
  • NET59 3

External Ids for NCLN Gene

Previous GeneCards Identifiers for NCLN Gene

  • GC19P003139
  • GC19P002952

Summaries for NCLN Gene

GeneCards Summary for NCLN Gene

NCLN (Nicalin) is a Protein Coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for NCLN Gene

  • May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

Gene Wiki entry for NCLN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCLN Gene

Genomics for NCLN Gene

Regulatory Elements for NCLN Gene

Genomic Location for NCLN Gene

Start:
3,185,563 bp from pter
End:
3,209,575 bp from pter
Size:
24,013 bases
Orientation:
Plus strand

Genomic View for NCLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCLN Gene

Proteins for NCLN Gene

  • Protein details for NCLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V3-NCLN_HUMAN
    Recommended name:
    Nicalin
    Protein Accession:
    Q969V3
    Secondary Accessions:
    • D6W613
    • O75252
    • Q6FI60
    • Q6ZMB7
    • Q8TAT7
    • Q96H48
    • Q96IS7
    • Q9BQH9
    • Q9BTX4
    • Q9NPP2

    Protein attributes for NCLN Gene

    Size:
    563 amino acids
    Molecular mass:
    62974 Da
    Quaternary structure:
    • Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.
    SequenceCaution:
    • Sequence=AAH03076.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH25926.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66502.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCLN Gene

Proteomics data for NCLN Gene at MOPED

Post-translational modifications for NCLN Gene

  • Ubiquitination at Lys99, Lys471, and Lys491
  • Glycosylation at Asn241 and Asn428
  • Modification sites at PhosphoSitePlus

Other Protein References for NCLN Gene

No data available for DME Specific Peptides for NCLN Gene

Domains for NCLN Gene

Protein Domains for NCLN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V3

UniProtKB/Swiss-Prot:

NCLN_HUMAN :
  • Q969V3
Family:
  • Belongs to the nicastrin family.
genes like me logo Genes that share domains with NCLN: view

No data available for Gene Families for NCLN Gene

Function for NCLN Gene

Molecular function for NCLN Gene

UniProtKB/Swiss-Prot Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

Gene Ontology (GO) - Molecular Function for NCLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17261586
genes like me logo Genes that share ontologies with NCLN: view

Phenotypes for NCLN Gene

genes like me logo Genes that share phenotypes with NCLN: view

Animal Model Products

CRISPR Products

miRNA for NCLN Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCLN Gene

Localization for NCLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCLN Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCLN Gene COMPARTMENTS Subcellular localization image for NCLN gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NCLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCLN: view

Pathways for NCLN Gene

SuperPathways for NCLN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
GO:0016485 protein processing --
genes like me logo Genes that share ontologies with NCLN: view

No data available for Pathways by source for NCLN Gene

Transcripts for NCLN Gene

Unigene Clusters for NCLN Gene

Nicalin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCLN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCLN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7:
SP8:

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NCLN Gene

GeneLoc Exon Structure for
NCLN
ECgene alternative splicing isoforms for
NCLN

Expression for NCLN Gene

mRNA expression in normal human tissues for NCLN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCLN Gene

SOURCE GeneReport for Unigene cluster for NCLN Gene Hs.657032

mRNA Expression by UniProt/SwissProt for NCLN Gene

Q969V3-NCLN_HUMAN
Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
genes like me logo Genes that share expressions with NCLN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NCLN Gene

Orthologs for NCLN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCLN 35
  • 98.64 (n)
  • 99.64 (a)
NCLN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCLN 35
  • 89.09 (n)
  • 94.31 (a)
NCLN 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCLN 35
  • 90.29 (n)
  • 95.2 (a)
NCLN 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncln 35
  • 87.15 (n)
  • 93.43 (a)
Ncln 16
Ncln 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCLN 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCLN 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncln 35
  • 87.21 (n)
  • 93.07 (a)
chicken
(Gallus gallus)
Aves NCLN 35
  • 73.5 (n)
  • 79.14 (a)
NCLN 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCLN 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncln 35
  • 72.86 (n)
  • 81.96 (a)
Str.1209 35
zebrafish
(Danio rerio)
Actinopterygii ncl1 35
  • 73.65 (n)
  • 76.68 (a)
ncl1 36
  • 73 (a)
OneToOne
wufb07e09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002549 35
  • 53.46 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4972 35
  • 48.2 (n)
  • 38.59 (a)
CG4972 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nra-2 35
  • 41.38 (n)
  • 32.92 (a)
nra-2 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G44330 35
  • 44.56 (n)
  • 37.15 (a)
rice
(Oryza sativa)
Liliopsida Os08g0102100 35
  • 46.09 (n)
  • 39.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10535 36
  • 36 (a)
OneToOne
Species with no ortholog for NCLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCLN Gene

ENSEMBL:
Gene Tree for NCLN (if available)
TreeFam:
Gene Tree for NCLN (if available)

Paralogs for NCLN Gene

No data available for Paralogs for NCLN Gene

Variants for NCLN Gene

Sequence variations from dbSNP and Humsavar for NCLN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4594 -- 3,209,485(+) CGTCA(G/T)GATGG utr-variant-3-prime
rs122690 -- 3,209,663(+) GCAGG(A/G)CTGTG downstream-variant-500B
rs122691 -- 3,209,679(+) AGTAC(A/G)TCACT downstream-variant-500B
rs186339 -- 3,197,001(+) AAGCA(C/G)CGGCT intron-variant
rs311614 -- 3,195,245(+) Ttttt(G/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCLN Gene

Variant ID Type Subtype PubMed ID
nsv910697 CNV Loss 21882294
nsv509716 CNV Insertion 20534489
dgv3648n71 CNV Loss 21882294
dgv3649n71 CNV Loss 21882294
nsv910720 CNV Loss 21882294
nsv910721 CNV Loss 21882294

Relevant External Links for NCLN Gene

HapMap Linkage Disequilibrium report
NCLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCLN Gene

Disorders for NCLN Gene

No disorders were found for NCLN Gene.

No data available for UniProtKB/Swiss-Prot for NCLN Gene

Publications for NCLN Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PMID: 17261586) Haffner C. … Haass C. (J. Biol. Chem. 2007) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 3 4

Products for NCLN Gene

Sources for NCLN Gene

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