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NCLN Gene

protein-coding   GIFtS: 52
GCID: GC19P003185

Nicalin

(Previous name: nicalin homolog (zebrafish))
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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
nicalin1 2
Nicastrin-Like Protein1 2 3
Nicalin Homolog (Zebrafish)1
NET592
Nicalin Homolog (Zebrefish)2

External Ids:    HGNC: 269231   Entrez Gene: 569262   Ensembl: ENSG000001259127   OMIM: 6091565   UniProtKB: Q969V33   

Export aliases for NCLN gene to outside databases

Previous GC identifers: GC19P003139 GC19P002952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NCLN Gene:
NCLN (nicalin) is a protein-coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: NCLN_HUMAN, Q969V3
Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal
patterning (By similarity)

Gene Wiki entry for NCLN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCLN gene promoter:
         Pax-5   NRSF form 1   HSF1 (long)   NRSF form 2   C/EBPalpha   PPAR-alpha   HEN1   HOXA5   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCLN promoter sequence
   Search Chromatin IP Primers for NCLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NCLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCLN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003185:  view genomic region     (about GC identifiers)

Start:
3,185,561 bp from pter      End:
3,209,573 bp from pter
Size:
24,013 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCLN_HUMAN, Q969V3 (See protein sequence)
Recommended Name: Nicalin precursor  
Size: 563 amino acids; 62974 Da
Subunit: Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are
otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3,
probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to
the gamma-secretase complex
Sequence caution: Sequence=AAH03076.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH25926.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66502.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D6W613 O75252 Q6FI60 Q6ZMB7 Q8TAT7 Q96H48 Q96IS7 Q9BQH9 Q9BTX4 Q9NPP2
Alternative splicing: 2 isoforms:  Q969V3-1   Q969V3-2   

Explore the universe of human proteins at neXtProt for NCLN: NX_Q969V3

Explore proteomics data for NCLN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99, Lys471, Lys491
  • Glycosylation2 at Asn241, Asn428
  • Modification sites at PhosphoSitePlus

  • See NCLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064555.2  
    ENSEMBL proteins: 
     ENSP00000466678   ENSP00000246117   ENSP00000467011   ENSP00000466300   ENSP00000466296  
     ENSP00000467693   ENSP00000466844  

    NCLN Human Recombinant Protein Products:

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    Novus Biologicals NCLN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCLN

     
    Search eBioscience for Proteins for NCLN 

     
    antibodies-online proteins for NCLN (6 products) 

     
    antibodies-online peptides for NCLN

    NCLN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NCLN
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    antibodies-online antibodies for NCLN (36 products) 

    NCLN Assay Products:

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    Cloud-Clone Corp. CLIAs for NCLN
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    antibodies-online kits for NCLN (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016574 Nicalin
     IPR007484 Peptidase_M28

    Graphical View of Domain Structure for InterPro Entry Q969V3

    ProtoNet protein and cluster: Q969V3

    UniProtKB/Swiss-Prot: NCLN_HUMAN, Q969V3
    Similarity: Belongs to the nicastrin family


    Find genes that share domains with NCLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCLN_HUMAN, Q969V3
    Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal
    patterning (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17261586
    GO:0008233peptidase activity IEA--
         
    Find genes that share ontologies with NCLN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NCLN:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NCLN

    miRNA
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    miRTarBase miRNAs that target NCLN:
    hsa-let-7e-5p (MIRT051553), hsa-mir-331-3p (MIRT043508), hsa-mir-615-3p (MIRT039945), hsa-mir-769-5p (MIRT039162)

    Block miRNA regulation of human, mouse, rat NCLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCLN (see all 9):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-188-3p hsa-miR-135b hsa-miR-125b hsa-miR-670 hsa-miR-3119 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidNCLN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NCLN

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    GenScript: all cDNA clones in your preferred vector: NCLN (NM_020170)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCLN

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCLN_HUMAN, Q969V3: Endoplasmic reticulum membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NCLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCLN
    Interactions:

        Search GeneGlobe Interaction Network for NCLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NCLN (Q969V33 ENSP000002461174) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    TNFRSF14Q929563, ENSP000003479484I2D: score=1 STRING: ENSP00000347948
    NOMO1Q151553, ENSP000002876674I2D: score=2 STRING: ENSP00000287667
    NOMO3P698493, ENSP000003822744I2D: score=1 STRING: ENSP00000382274
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0009966regulation of signal transduction IEA--
    GO:0016485protein processing ----

    Find genes that share ontologies with NCLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCLN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCLN gene: 
    NM_020170.3  

    Unigene Cluster for NCLN:

    Nicalin
    Hs.657032  [show with all ESTs]
    Unigene Representative Sequence: NM_020170
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590671 ENST00000246117(uc002lxh.1 uc002lxi.3 uc002lxj.1 uc002lxk.3)
    ENST00000588428 ENST00000587740 ENST00000592737 ENST00000586904 ENST00000592235
    ENST00000591062
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCLN (see all 9):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-188-3p hsa-miR-135b hsa-miR-125b hsa-miR-670 hsa-miR-3119 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidNCLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NCLN
    Predesigned siRNA for gene silencing in human, mouse, rat NCLN
    Clone
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    OriGene clones in human, mouse for NCLN (see all 7)
    OriGene ORF clones in mouse, rat for NCLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCLN (NM_020170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCLN
    Primer
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    OriGene qPCR primer pairs and template standards for NCLN
    OriGene qSTAR qPCR primer pairs in human, mouse for NCLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCLN
      QuantiTect SYBR Green Assays in human, mouse, rat NCLN
      QuantiFast Probe-based Assays in human, mouse, rat NCLN

    Additional mRNA sequence: 

    AK125002.1 AK172848.1 AK314044.1 AL136567.1 AL365369.1 BC003076.2 BC007275.1 BC008920.2 
    BC010064.2 BC013283.2 BC019091.2 BC025926.1 CR533566.1 

    13 DOTS entries:

    DT.315055  DT.91892788  DT.100709808  DT.95135351  DT.100786296  DT.75166473  DT.97787776  DT.100705323 
    DT.100786299  DT.40277427  DT.91753152  DT.91834156  DT.91885082 

    Selected AceView cDNA sequences (see all 338):

    BF765431 AW438845 CD368591 BF765130 BF766183 AW594675 AW235302 CF125312 
    BM480314 AW780339 BU191330 AI685616 BU624801 BF766034 BU631716 BQ691305 
    AA318575 BQ069523 BU860483 BF765716 NM_020170 BM715443 BQ691276 AI658574 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCLN (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^
    SP1:              -     -                                                                 -                       -     -                                       
    SP2:                                                                                      -                       -     -                                       
    SP3:                                                                                      -                       -     -                                       
    SP4:                                                                                      -                       -     -                       -     -     -   
    SP5:                                                                                      -                       -                                             

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NCLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGATGCAC
    NCLN Expression
    About this image

    NCLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657032

    UniProtKB/Swiss-Prot: NCLN_HUMAN, Q969V3
    Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart

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    QuantiFast Probe-based Assays in human, mouse, rat NCLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCLN gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncln1 , 5 nicalin homolog (zebrafish)1, 5 87.15(n)1
    93.43(a)1
      10 (39.72 cM)5
    1034251  NM_134009.31  NP_598770.11 
     814862495 
    chicken
    (Gallus gallus)
    Aves NCLN1 nicalin 73.5(n)
    79.14(a)
      426048  NM_001031354.1  NP_001026525.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCLN6
    nicalin
    83(a)
    1 ↔ 1
    GL343717.1(159859-181571)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045096.12   -- 75.87(n)    BC045096.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb07e092 Danio rerio cDNA clone MGC65783 IMAGE6790443, complete more 75.83(n)    BC056523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49721 CG4972 48.2(n)
    38.59(a)
      34388  NM_135534.3  NP_609378.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nra-21 nra-2 41.38(n)
    32.92(a)
      172803  NM_001129042.2  NP_001122514.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G443301 AT3G44330 44.56(n)
    37.15(a)
      823558  NM_114301.3  NP_190019.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01021001 Os08g0102100 46.09(n)
    39.09(a)
      4344424  NM_001067301.1  NP_001060766.1 


    ENSEMBL Gene Tree for NCLN (if available)
    TreeFam Gene Tree for NCLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCLN (see all 806)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118832281,2
    H--3183910(+) TTTAGG/TGGGGA 1 -- us2k10--------
    rs756205551,2
    C,F--3184010(+) GTTGGC/GTGACC 1 -- us2k11Minor allele frequency- G:0.15EA 120
    rs5622571,2
    C,F,O,A,H--3184083(+) GGCTTC/TTCGCT 1 -- us2k1 tfbs326Minor allele frequency- T:0.33NA EA MN NS WA CSA 3010
    rs1831120521,2
    C--3184134(+) CCGCAC/TCTTCC 1 -- us2k10--------
    rs1427722351,2
    --3184146(+) TCCTTC/TGTCAC 1 -- us2k10--------
    rs1879980891,2
    --3184192(+) TTAGCA/GTCACC 1 -- us2k10--------
    rs798892811,2
    --3184204(+) CCTCCA/TGGAAG 1 -- us2k10--------
    rs5632911,2
    C,F--3184210(+) GGAAGT/CCTTCT 1 -- us2k110Minor allele frequency- C:0.34MN NA WA CSA EA 554
    rs1918707631,2
    --3184247(+) CTCTAC/GGCTCC 1 -- us2k10--------
    rs568999511,2
    C--3184281(+) TGACAG/ACTCTG 1 -- us2k13Minor allele frequency- A:0.19WA NA 240

    HapMap Linkage Disequilibrium report for NCLN (3185561 - 3209573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NCLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509716CNV Insertion20534489
    dgv3648n71CNV Loss21882294
    nsv910721CNV Loss21882294
    dgv3649n71CNV Loss21882294
    nsv910720CNV Loss21882294
    nsv910697CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCLN
    DNA2.0 Custom Variant and Variant Library Synthesis for NCLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609156    OMIM disorders: --


    Find genes that share disorders with NCLN           About GenesLikeMe


    Export disorders for NCLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCLN gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NCLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 2 Haffner C.... Haass C. (EMBO J. 2004)
    6. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PubMed id 17261586)1, 9 Haffner C.... Haass C. (J. Biol. Chem. 2007)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56926 HGNC: 26923 AceView: NICALIN Ensembl:ENSG00000125912 euGenes: HUgn56926
    ECgene: NCLN H-InvDB: NCLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NCLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCLN gene:
    Search GeneIP for patents involving NCLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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