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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NCL Gene

protein-coding GIFtS: 63
GCID: GC02M232318

nucleolin

Explore 44 diseases affiliated with
NCL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleolin¹
C23¹ ²
Protein C23³

External Ids:	HGNC: 7667¹	Entrez Gene: 4691²	Ensembl: ENSG00000115053⁷	OMIM: 164035⁵	UniProtKB: P19338³

Export aliases for NCL gene to outside databases

Previous GC identifers: GC02M230377 GC02M231051 GC02M232283 GC02M232521 GC02M232522 GC02M232144 GC02M232027 GC02M224160

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCL:

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is

located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and

spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338

Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with

intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It

is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of

transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric

single-stranded DNA 5'-TTAGGG-3' repeats

Gene Wiki entry for NCL (Nucleolin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NCL gene promoter:
TBP AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCL promoter sequence

Search SABiosciences Chromatin IP Primers for NCL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q12-qter

NCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCL gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M232318: view genomic region (about GC identifiers)

Start:	232,318,242 bp from pter	End:	232,348,352 bp from pter
Size:	30,111 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338 (See protein sequence)

Recommended Name: Nucleolin

Size: 710 amino acids; 76614 Da

Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,

HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,

RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with APTX and NSUN2. Component

of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least

composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and

NCL/nucleolin. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important

for nucleolar localization of TERT. Interacts with ERBB4. Interacts with GZF1; this interaction is important for

nucleolar localization of GZF1. Interacts with NVL and C1QBP

Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing

untranslated mRNAs

Sequence caution: Sequence=BAC03738.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;

3 PDB 3D structures from and Proteopedia for NCL:

2FC8 (3D)

2FC9 (3D)

2KRR (3D)

Secondary accessions: Q53SK1 Q8NB06 Q9UCF0 Q9UDG1

Explore the universe of human proteins at neXtProt for NCL: NX_P19338

Post-translational modifications:

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results

in a glycine chain on the gamma-carboxyl group (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P19338

NCL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005372.2

ENSEMBL proteins:

ENSP00000318195 ENSP00000349410 ENSP00000401620 ENSP00000392747 ENSP00000413775

ENSP00000401322

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NCL OriGene Custom Protein Services for NCL
	GenScript Custom Purified and Recombinant Proteins Services for NCL
	Novus Biologicals NCL Protein Novus Biologicals NCL Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NCL

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	IEA	--
GO:0005730	nucleolus	IDA	--
GO:0005938	cell cortex	IDA	16403913
GO:0030529	ribonucleoprotein complex	IDA	18809582

NCL for ontologies About GeneDecksing

NCL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NCL
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NCL
	OriGene Antibodies (see all 3): NCL OriGene Custom Antibody Services for NCL
	GenScript Superior Antibodies for NCL
	Novus Biologicals NCL Antibodies
	Abcam antibodies for NCL
	Uscn Antibodies for NCL
	ThermoFisher Antibody for NCL

Assay Products for NCL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NCL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NCL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NCL for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P19338

ProtoNet protein and cluster: P19338

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338

Similarity: Contains 4 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338

Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with

intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It

is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of

transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric

single-stranded DNA 5'-TTAGGG-3' repeats

Genatlas biochemistry entry for NCL:

nucleolin,major multifunctional nucleolar protein of exponentially growing cells,characterized by unique tripartite

function within each domain,performing activities i.e. a specific DNA helicase and DNA-dependent ATPase,also acting as

a sequence-specific RNA binding protein an autoantigen,a component of B cell specific transcription factor,involved in

ribosome biogenesis,cytokinesis,nucleogenesis,cell proliferation and growth,chromatin remodeling etc...

miRNA Products:		miRTarBase miRNAs that target NCL: hsa-mir-30a (MIRT005204)

		OriGene 3'-UTR Clone: NCL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCL
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NCL (see all 9):
		hsa-miR-203 hsa-miR-3673 hsa-miR-206 hsa-miR-548d-3p hsa-miR-493* hsa-miR-3148 hsa-miR-1 hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: NCL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCL (see all 7) OriGene shRNA RFP: NCL OriGene siRNA: NCL
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NCL

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCL OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NCL (NM_005381)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NCL
		Search LifeMap BioReagents cell lines for NCL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCL

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IDA	8321232
GO:0005515	protein binding	IPI	19174163
GO:0008022	protein C-terminus binding	IPI	16403913

NCL for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for NCL:

Decreased cell number	Decreased viability of wild-ty	G0/1 arrest	Increased circadian period len
Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pathogenic Escherichia coli infection

Pathogenic Escherichia coli infection

1.00

Pathogenic Escherichia coli infection

0.98

Development_CNTF receptor signaling

Cell adhesion PLAU signaling

0.35

Cell adhesion_PLAU signaling

0.35

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Validated targets of C-MYC transcriptional activation

Validated targets of C-MYC transcriptional activation

1.00

Aurora B signaling

Aurora B signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NCL

Cell adhesion PLAU signaling

2 Cell Signaling Technology (CST) Pathways for NCL

	Chromatin Regulation / Acetylation
	Translational Control

1 GeneGo (Thomson Reuters) Pathway for NCL

Cell adhesion PLAU signaling

4 BioSystems Pathways for NCL

	Pathogenic Escherichia coli infection
	Regulation of Telomerase
	Validated targets of C-MYC transcriptional activation
	Aurora B signaling

1 Kegg Pathway (Kegg details for NCL):

Pathogenic Escherichia coli infection

NCL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NCL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/823 Interacting proteins for NCL (P19338^{1, 2, 3} ENSP00000318195⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 823)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDM2	Q00987¹^,²^,³, ENSP00000417281⁴	EBI-352553,EBI-389668 MINT-8292184 MINT-8291996 MINT-8291950 MINT-8291977 MINT-8292547 MINT-8292023 I2D: score=3 STRING: ENSP00000417281
RHOA	P61586²^,³, ENSP00000400175⁴	MINT-8086635 MINT-8086576 MINT-8086679 MINT-8086602 MINT-8086696 I2D: score=1 STRING: ENSP00000400175
TP53	P04637²^,³, ENSP00000269305⁴	MINT-8292070 MINT-8292213 I2D: score=4 STRING: ENSP00000269305
TOP1	P11387²^,³, ENSP00000354522⁴	MINT-73226 I2D: score=5 STRING: ENSP00000354522
FMR1	Q06787²^,³, ENSP00000359506⁴	MINT-6488791 I2D: score=4 STRING: ENSP00000359506

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	16403913

NCL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NCL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NCL
10/31 Novoseek chemical compound relationships for NCL gene (see all 31) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fructosyllysine	66.3	1	11425191 (1)
pp 100	66	1	12636255 (1)
mnda	63	6	8749721 (2), 9328447 (2)
roscovitine	47.9	1	18457570 (1)
actinomycin	44	1	12185196 (1)
actinomycin d	41.2	1	14729462 (1)
heparan sulfate	39.2	4	14557624 (1), 16474431 (1), 11277697 (1), 16156786 (1)
okadaic acid	37.9	5	14679209 (2), 1370482 (1), 1663450 (1)
silver	34.1	8	7474921 (3), 7523152 (1), 10588056 (1), 1584962 (1) (see all 5)
camptothecin	32.5	1	12506112 (1)

Search CenterWatch for drugs/clinical trials and news about NCL / NUCL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NCL gene:

NM_005381.2

Unigene Cluster for NCL:

Nucleolin

Hs.79110 [show with all ESTs]

Unigene Representative Sequence: AK128584

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000322723(uc002vru.3) ENST00000461347 ENST00000356936 ENST00000466274

ENST00000494618 ENST00000454824 ENST00000417652 ENST00000453992 ENST00000436894

ENST00000484328

miRNA Products:		OriGene 3'-UTR Clone: NCL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCL
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NCL (see all 9):
		hsa-miR-203 hsa-miR-3673 hsa-miR-206 hsa-miR-548d-3p hsa-miR-493* hsa-miR-3148 hsa-miR-1 hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: NCL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCL (see all 7) OriGene shRNA RFP: NCL OriGene siRNA: NCL
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		GenScript: all cDNA clones in your preferred vector: NCL (NM_005381)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCL

Additional cDNA sequence:

AK000221.1 AK000250.1 AK001314.1 AK091742.1 AK095897.1 AK122805.1 AK127608.1 AK128584.1

AY320411.1 BC002343.2 BC006494.2 BC006516.2

24/106 DOTS entries (see all 106):

DT.75168967 DT.120941909 DT.100687112 DT.91777963 DT.100687109 DT.91777931 DT.91999304 DT.100767962

DT.101985508 DT.100687125 DT.92066695 DT.100687119 DT.91877237 DT.95306654 DT.95254249 DT.100687115

DT.100687108 DT.120941798 DT.100687130 DT.95106204 DT.120941866 DT.120941915 DT.100034306 DT.100687107

24/1005 AceView cDNA sequences (see all 1005):

BE314937 AA411363 BX383571 BM673227 BM835738 CB151689 BM827555 BP357577

BU509039 BP361574 BM835180 BM479439 BQ878608 BG676563 CB162826 BC002343

BU182205 BP366166 CB133067 BQ712263 BM971736 NM_005381 BM756164 CB132278

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NCL (see all 16) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^
SP1:					-		-		-		-		-								-																								-
SP2:					-		-		-		-		-				-		-		-		-		-		-		-		-														-
SP3:
SP4:																																													-
SP5:					-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-										-

ExUns:	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	·	19c	·	19d	^	20a	·	20b	·	20c
SP1:			-		-
SP2:
SP3:			-
SP4:	-		-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for NCL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NCL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTTGCTT

About this image
See NCL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCL

SOURCE GeneReport for Unigene cluster: Hs.79110

SABiosciences Expression via Pathway-Focused PCR Array including NCL:

Telomeres & Telomerase in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCL gene from 8/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NCL¹	nucleolin	70.94(n) 69.98(a)		396201 NM_205265.1 NP_990596.1
lizard (Anolis carolinensis)	Reptilia	NCL⁶ TCOF1⁶	--	56(a) 5(a)	1 ↔ 1 possible ortholog	GL343304.1(1620176-1633855) 2(138888261-138927521)
African clawed frog (Xenopus laevis)	Amphibia	LOC397919²	nucleolin	75.86(n)		X72957.1
zebrafish (Danio rerio)	Actinopterygii	ncl¹	nucleolin	60.61(n) 57.23(a)		767714 NM_001076652.2 NP_001070120.2
fruit fly (Drosophila melanogaster)	Insecta	Nopp140⁶	Nopp140	8(a)	1 ↔ 1	3L(21825874-21829785)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NSR1¹	Nsr1p	46(n) 35.06(a)		853064 NP_011675.1
thale cress (Arabidopsis thaliana)	eudicotyledons	NUC-L1¹	nucleolin	48.69(n) 38.23(a)		841314 NM_103785.3 NP_175322.1
rice (Oryza sativa)	Liliopsida	Os08g0192900¹	hypothetical protein	47.63(n) 37.4(a)		4344865 NM_001067713.1 NP_001061178.1

ENSEMBL Gene Tree for NCL (if available)
TreeFam Gene Tree for NCL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NCL gene

RBM19² SART3²

5 SIMAP similar genes for NCL using alignment to 8 protein entries: NUCL_HUMAN (see all proteins):

RBMY1A1 CIRBP RBM3 HNRNPA1 TRA2A

NCL for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for NCL
PGOHUM00000242809 PGOHUM00000240550 PGOHUM00000263228 PGOHUM00000241553

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11542690^1,2	C,F,H	--	224161216(-)	`GTTGGT/CTTTGA`	1	--	ut5¹		7	EA NS NA	912
rs73996751^1,2	C,	--	224161315(+)	`GTCATC/TGATCA`	1	--	ut5¹		1	WA	2
rs16828077^1,2	C,F,H,	--	224161893(+)	`GCTGGG/AGAGCC`	1	--	int¹		8	NA NS EA WA	678
rs77122043^1,2	F,	--	224161902(+)	`CCATCC/TCACAG`	1	--	int¹		1	WA	118
rs112840566^1,2	C	--	224162331(+)	`TGGCTG/CTGGGA`	1	--	spd¹		1	CSA	1
rs79523334^1,2		--	224162427(+)	`ACTTGT/CTATAG`	1	--	int¹		1	WA	118
rs112789327^1,2	C	--	224162823(+)	`AACTTA/C/TCGGCT`	1	--	spa¹		1	CSA	1
rs112521366^1,2	C	--	224162824(+)	`ACTTAC/G/TGGCTT`	1	--	spa¹		1	CSA	1
rs2595519^1,2	H	--	224162989(+)	`AGTAAG/TTTACC`	1	--	int¹		4	NS EA	420
rs2595521^1,2	H	--	224163103(+)	`TATTTG/AGCTTT`	1	--	int¹		4	NS EA	420

HapMap Linkage Disequilibrium report for NCL (232318242 - 232348352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NCL
1 Indel: 58972
Human Gene Mutation Database (HGMD): NCL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCL

DNA2.0 Custom Variant and Variant Library Synthesis for NCL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NCL for disorders           About GeneDecksing

OMIM gene information: 164035    OMIM disorders: --

20/44 diseases for NCL (see all 44):    About MalaCards

estrogen-receptor positive breast cancer klippel-feil syndrome spinal cord disease parainfluenza virus type 3

wiskott-aldrich syndrome treacher collins syndrome lupus erythematosus metastasis efficiency

systemic lupus erythematosus down syndrome chronic lymphocytic leukemia acute myeloid leukemia

herpes simplex lymphocytic leukemia werner syndrome myeloid leukemia

cervical cancer ependymoma myelodysplastic syndrome breast cancer

10/20 Novoseek disease relationships for NCL gene (see all 20) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	21.5	33	16891465 (2), 17633394 (2), 19235198 (2), 17484127 (2) (see all 18)
hepatitis delta	14.4	1	9516470 (1)
hiv infections	13.2	4	16156786 (2), 16474431 (1), 10710212 (1)
tumors	12.3	21	18560571 (5), 20140822 (2), 18821389 (1), 17615292 (1) (see all 13)
retinoblastoma	7.82	3	16698799 (1), 8392280 (1), 14617691 (1)
shock	7.14	10	16137033 (2), 20221403 (2), 10811822 (1), 12605602 (1) (see all 6)
immunodeficiency	6.97	4	14717698 (1), 14624373 (1), 14978336 (1)
breast carcinoma	4.22	2	14638862 (1), 20075200 (1)
lupus erythematosus systemic	0	3	1454059 (2), 2005395 (1)
leukemia	0	6	12506112 (2), 18278785 (1), 14978336 (1), 7626687 (1)

Export disorders for NCL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NCL gene, integrated from 9 sources (see all 404):
(articles sorted by number of sources associating them with NCL)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization and chromosomal localization of the human nucleolin gene. (PubMed id 2394707)^{1, 2, 3} Srivastava M.... Burns A.L. (1990)
Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PubMed id 17674968)^{1, 2, 9} Dambara A....Takahashi M. (2007)
Nucleolin interacts with telomerase. (PubMed id 15371412)^{1, 2, 9} Khurts S....Murakami S. (2004)
Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. (PubMed id 7993898)^{1, 2, 9} Jordan P.... Kubler D. (1994)
Structure and function of the N-terminal nucleolin bi nding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nu cleolar localization signal. (PubMed id 21474449)^{1, 2} Fujiwara Y....Hiroaki H. (2011)
Aurora-B regulates RNA methyltransferase NSUN2. (PubMed id 17215513)^{1, 2} Sakita-Suto S.... Tatsuka M. (2007)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4691	HGNC: 7667	AceView: NCL	Ensembl:ENSG00000115053	euGenes: HUgn4691
ECgene: NCL	Kegg: 4691	H-InvDB: NCL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NCL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NCL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NCL gene:
Search GeneIP for patents involving NCL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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