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NCL Gene

protein-coding   GIFtS: 64
GCID: GC02M232318

Nucleolin

  See NCL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
nucleolin1 2
C232
Protein C233

External Ids:    HGNC: 76671   Entrez Gene: 46912   Ensembl: ENSG000001150537   OMIM: 1640355   UniProtKB: P193383   

Export aliases for NCL gene to outside databases

Previous GC identifers: GC02M230377 GC02M231051 GC02M232283 GC02M232521 GC02M232522 GC02M232144 GC02M232027 GC02M224160


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCL Gene:
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes.
It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13
introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NCL Gene:
NCL (nucleolin) is a protein-coding gene. Diseases associated with NCL include parainfluenza virus type 3. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338
Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with
intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone
H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process
of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the
telomeric single-stranded DNA 5'-TTAGGG-3' repeats

Gene Wiki entry for NCL (Nucleolin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCL gene promoter:
         TBP   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCL promoter sequence
   Search Chromatin IP Primers for NCL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

NCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M232318:  view genomic region     (about GC identifiers)

Start:
232,318,242 bp from pter      End:
232,348,352 bp from pter
Size:
30,111 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338 (See protein sequence)
Recommended Name: Nucleolin  
Size: 710 amino acids; 76614 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APTX
and NSUN2. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a
complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA
polymerase II, SUPT5H, and NCL/nucleolin. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with
TERT; the interaction is important for nucleolar localization of TERT. Interacts with ERBB4. Interacts with GZF1;
this interaction is important for nucleolar localization of GZF1. Interacts with NVL and C1QBP. Interacts with
AICDA (By similarity)
Sequence caution: Sequence=BAC03738.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites;
3 PDB 3D structures from and Proteopedia for NCL:
2FC8 (3D)        2FC9 (3D)        2KRR (3D)    
Secondary accessions: Q53SK1 Q8NB06 Q9UCF0 Q9UDG1

Explore the universe of human proteins at neXtProt for NCL: NX_P19338

Explore proteomics data for NCL at MOPED

Post-translational modifications: 

  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and
    results in a glycine chain on the gamma-carboxyl group (By similarity)1
  • Ubiquitination2 at Lys324, Lys333, Lys348, Lys370, Lys398, Lys403, Lys467, Lys513, Lys572, Lys577,
                                 Lys610
  • Modification sites at PhosphoSitePlus

  • See NCL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005372.2  
    ENSEMBL proteins: 
     ENSP00000318195   ENSP00000349410   ENSP00000401620   ENSP00000392747   ENSP00000413775  
     ENSP00000401322  

    NCL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NCL
    OriGene Protein Over-expression Lysate for NCL
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NCL
    GenScript Custom Purified and Recombinant Proteins Services for NCL
    Novus Biologicals NCL Protein
    Novus Biologicals NCL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NCL
    Cloud-Clone Corp. Proteins for NCL

     
    Search eBioscience for Proteins for NCL 

    NCL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NCL
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NCL 
    OriGene Antibodies for NCL
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    Novus Biologicals NCL Antibodies
    Abcam antibodies for NCL
    Cloud-Clone Corp. Antibodies for NCL
    ThermoFisher Antibody for NCL
    LSBio Antibodies in human, mouse, rat for NCL

    NCL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCL
    Cloud-Clone Corp. CLIAs for NCL
    Search eBioscience for ELISAs for NCL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P19338

    ProtoNet protein and cluster: P19338

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: NUCL_HUMAN, P19338
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    Find genes that share domains with NCL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUCL_HUMAN, P19338
    Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with
    intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone
    H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process
    of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the
    telomeric single-stranded DNA 5'-TTAGGG-3' repeats

         Genatlas biochemistry entry for NCL:
    nucleolin,major multifunctional nucleolar protein of exponentially growing cells,characterized by unique
    tripartite function within each domain,performing activities i.e. a specific DNA helicase and DNA-dependent
    ATPase,also acting as a sequence-specific RNA binding protein an autoantigen,a component of B cell specific
    transcription factor,involved in ribosome biogenesis,cytokinesis,nucleogenesis,cell proliferation and
    growth,chromatin remodeling etc...

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA8321232
    GO:0005488binding ----
    GO:0005515protein binding IPI12427757
         
    Find genes that share ontologies with NCL           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for NCL:
     Decreased cell number  Decreased viability of wild-ty  G0/1 arrest  Increased circadian period len 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCL

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCL:
    hsa-mir-30a-5p (MIRT005204), hsa-mir-598-3p (MIRT040493), hsa-mir-221-3p (MIRT046909), hsa-mir-92a-3p (MIRT049002), hsa-mir-193b-3p (MIRT041552), hsa-mir-615-3p (MIRT039947), hsa-mir-92b-3p (MIRT040534), hsa-mir-744-5p (MIRT037670), hsa-mir-877-3p (MIRT036889), hsa-mir-197-3p (MIRT048058)

    Block miRNA regulation of human, mouse, rat NCL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCL (see all 9):
    hsa-miR-203 hsa-miR-3673 hsa-miR-206 hsa-miR-548d-3p hsa-miR-493* hsa-miR-3148 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNCL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NCL
    Predesigned siRNA for gene silencing in human, mouse, rat NCL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCL

    Clone
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    OriGene clones in human, mouse for NCL (see all 7)
    OriGene ORF clones in mouse, rat for NCL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCL (NM_005381)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCL
    Addgene plasmids for NCL 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NCL 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUCL_HUMAN, P19338: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
    untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--
    GO:0005938cell cortex IDA16403913
    GO:0030529ribonucleoprotein complex IDA17289661

    Find genes that share ontologies with NCL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCL About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    2Translation Insulin regulation of translation
    Cell adhesion PLAU signaling0.35
    3Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    4Translational Control
    Translational Control
    5Regulation of Telomerase
    Regulation of Telomerase


    Find genes that share SuperPaths with NCL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for NCL
        Chromatin Regulation / Acetylation
    Translational Control

    1 GeneGo (Thomson Reuters) Pathway for NCL
        Cell adhesion PLAU signaling

    4 BioSystems Pathways for NCL
        Pathogenic Escherichia coli infection
    Regulation of Telomerase
    Aurora B signaling
    Validated targets of C-MYC transcriptional activation


    1 Kegg Pathway  (Kegg details for NCL):
        Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including NCL: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NCL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCL (P193381, 2, 3 ENSP000003181954) via UniProtKB, MINT, STRING, and/or I2D (see all 973)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-346967,EBI-389668 MINT-8292184 MINT-8291996 MINT-8291950 MINT-8291977 MINT-8292547 MINT-8292023 I2D: score=3 STRING: ENSP00000417281
    RHOAP615861, 2, 3, ENSP000004001754EBI-346967,EBI-446668 MINT-8086635 MINT-8086576 MINT-8086679 MINT-8086602 MINT-8086696 I2D: score=1 STRING: ENSP00000400175
    TP53P046371, 2, 3, ENSP000002693054EBI-346967,EBI-366083 MINT-8292070 MINT-8292213 I2D: score=4 STRING: ENSP00000269305
    NCLP193381, 2EBI-346967,EBI-346967 MINT-8175889 MINT-8175528 MINT-8175194 MINT-8176128 MINT-8176093
    TOP1P113872, 3, ENSP000003545224MINT-73226 I2D: score=5 STRING: ENSP00000354522
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA16403913

    Find genes that share ontologies with NCL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCL (NUCL)

    Selected Novoseek inferred chemical compound relationships for NCL gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructosyllysine 66.3 1 11425191 (1)
    pp 100 66 1 12636255 (1)
    mnda 63 6 8749721 (2), 9328447 (2)
    roscovitine 47.9 1 18457570 (1)
    actinomycin 44 1 12185196 (1)
    actinomycin d 41.2 1 14729462 (1)
    heparan sulfate 39.2 4 14557624 (1), 16474431 (1), 11277697 (1), 16156786 (1)
    okadaic acid 37.9 5 14679209 (2), 1370482 (1), 1663450 (1)
    silver 34.1 8 7474921 (3), 7523152 (1), 10588056 (1), 1584962 (1) (see all 5)
    camptothecin 32.5 1 12506112 (1)



    Find genes that share compounds with NCL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCL gene: 
    NM_005381.2  

    Unigene Cluster for NCL:

    Nucleolin
    Hs.79110  [show with all ESTs]
    Unigene Representative Sequence: AK128584
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322723(uc002vru.3) ENST00000461347 ENST00000356936 ENST00000466274
    ENST00000494618 ENST00000454824 ENST00000417652 ENST00000453992 ENST00000436894
    ENST00000484328
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCL (see all 9):
    hsa-miR-203 hsa-miR-3673 hsa-miR-206 hsa-miR-548d-3p hsa-miR-493* hsa-miR-3148 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNCL 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCL (NM_005381)
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    Addgene plasmids for NCL 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NCL
      QuantiTect SYBR Green Assays in human, mouse, rat NCL
      QuantiFast Probe-based Assays in human, mouse, rat NCL

    Additional mRNA sequence: 

    AK000221.1 AK000250.1 AK001314.1 AK091742.1 AK095897.1 AK122805.1 AK127608.1 AK128584.1 
    AY320411.1 BC002343.2 BC006494.2 BC006516.2 

    Selected DOTS entries (see all 99):

    DT.75168967  DT.101985508  DT.100687125  DT.92066695  DT.100687112  DT.100687109  DT.100687119  DT.91877237 
    DT.95254249  DT.91777963  DT.120941909  DT.95306654  DT.100767962  DT.100687115  DT.100687108  DT.91777931 
    DT.100687130  DT.95106204  DT.100034306  DT.100687107  DT.120941775  DT.120941780  DT.102843995  DT.120941917 

    Selected AceView cDNA sequences (see all 1005):

    BM905709 BU179468 BM761058 BE297270 BQ918381 BU735820 AU118987 AU280689 
    CR605221 AA411363 BM738435 CA437775 CB111471 BU191143 BP351745 BX383571 
    BP340803 BM472598 BX338963 BM989798 F03226 CB107217 BP380604 BQ927806 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCL (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^
    SP1:              -     -     -     -     -                       -                                                                       -                     
    SP2:              -     -     -     -     -           -     -     -     -     -     -     -     -                                         -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                             -                     

    ExUns: 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c · 19d ^ 20a · 20b · 20c
    SP1:        -     -                                                                           
    SP2:                                                                                          
    SP3:        -                                                                                 
    SP4:  -     -     -     -     -     -     -     -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NCL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NCL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTGCTT
    NCL Expression
    About this image


    NCL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    NCL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79110
        Pathway & Disease-focused RT2 Profiler PCR Array including NCL: 
              Telomeres & Telomerase in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NCL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncl1 , 5 nucleolin1, 5 87.67(n)1
    85.35(a)1
      1 (43.94 cM)5
    179751  NM_010880.31  NP_035010.31 
     863447195 
    chicken
    (Gallus gallus)
    Aves NCL6
    Gallus gallus nucleolin (NCL), mRNA.
    59(a)
    1 ↔ 1
    9(14750404-14758732)
    lizard
    (Anolis carolinensis)
    Reptilia NCL6
    nucleolin
    58(a)
    1 ↔ 1
    GL343304.1(1620176-1635356)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979192 nucleolin 75.86(n)    X72957.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncl6
    nucleolin
    50(a)
    1 ↔ 1
    22(39555553-39572992) ENSDARG00000002710
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NSR16
    Nucleolar protein that binds nuclear localization ...
    32(a)
    1 ↔ 1
    VII(806412-807656) YGR159C


    ENSEMBL Gene Tree for NCL (if available)
    TreeFam Gene Tree for NCL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCL gene
    4 SIMAP similar genes for NCL using alignment to 8 protein entries:     NUCL_HUMAN (see all proteins):
    RBMY1A1    CIRBP    HNRNPA1    RBM3

    Find genes that share paralogs with NCL           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for NCL
    PGOHUM00000242809 PGOHUM00000240550 PGOHUM00000263228 PGOHUM00000241553


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCL (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342388221,2
    C--231700807(+) AAAAAAA/-GAAAG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1428495991,2
    --232323247(+) ATGGAA/GATATA 1 -- int10--------
    rs731001851,2
    C--232323248(+) TGGAGA/CTATAG 1 -- int12Minor allele frequency- C:0.02WA 120
    rs1510639161,2
    --232323383(+) ACATTA/GCAACT 1 -- int10--------
    rs25955281,2
    H--232323468(+) TAATAA/GTTCTT 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs25955291,2
    H--232323485(+) TATAAA/GAGTGC 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs1424805881,2
    --232323495(+) CTCTTA/GCTTGC 1 -- int10--------
    rs1854138591,2
    --232323592(+) AGGAAA/GCCAAA 1 -- int10--------
    rs746229631,2
    C,F--232323640(+) GGAAAT/AGGGTT 1 -- int11Minor allele frequency- A:0.04EA 120
    rs1446073121,2
    --232323644(+) ATGGGC/TTACAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NCL (232318242 - 232348352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NCL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270903CNV Insertion20981092
    nsv819681CNV Loss19587683
    nsv834567CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCL
    DNA2.0 Custom Variant and Variant Library Synthesis for NCL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164035    OMIM disorders: --

    1 disease for NCL:    
    About MalaCards
    parainfluenza virus type 3


    Find genes that share disorders with NCL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NCL gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 21.5 33 16891465 (2), 17633394 (2), 19235198 (2), 17484127 (2) (see all 18)
    hepatitis delta 14.4 1 9516470 (1)
    hiv infections 13.2 4 16156786 (2), 16474431 (1), 10710212 (1)
    tumors 12.3 21 18560571 (5), 20140822 (2), 18821389 (1), 17615292 (1) (see all 13)
    retinoblastoma 7.82 3 16698799 (1), 8392280 (1), 14617691 (1)
    shock 7.14 10 16137033 (2), 20221403 (2), 10811822 (1), 12605602 (1) (see all 6)
    immunodeficiency 6.97 4 14717698 (1), 14624373 (1), 14978336 (1)
    breast carcinoma 4.22 2 14638862 (1), 20075200 (1)
    lupus erythematosus systemic 0 3 1454059 (2), 2005395 (1)
    leukemia 0 6 12506112 (2), 18278785 (1), 14978336 (1), 7626687 (1)


    Export disorders for NCL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCL gene, integrated from 10 sources (see all 448):
    (articles sorted by number of sources associating them with NCL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the human nucleolin gene. (PubMed id 2394707)1, 2, 3 Srivastava M.... Burns A.L. (J. Biol. Chem. 1990)
    2. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PubMed id 17674968)1, 2, 9 Dambara A.... Takahashi M. (Exp. Cell Res. 2007)
    3. Nucleolin interacts with telomerase. (PubMed id 15371412)1, 2, 9 Khurts S.... Murakami S. (J. Biol. Chem. 2004)
    4. Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. (PubMed id 7993898)1, 2, 9 Jordan P.... Kubler D. (Biochemistry 1994)
    5. Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal. (PubMed id 21474449)1, 2 Fujiwara Y....Hiroaki H. (J. Biol. Chem. 2011)
    6. Aurora-B regulates RNA methyltransferase NSUN2. (PubMed id 17215513)1, 2 Sakita-Suto S.... Tatsuka M. (Mol. Biol. Cell 2007)
    7. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4691 HGNC: 7667 AceView: NCL Ensembl:ENSG00000115053 euGenes: HUgn4691
    ECgene: NCL Kegg: 4691 H-InvDB: NCL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCL gene:
    Search GeneIP for patents involving NCL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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