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NCKIPSD Gene

protein-coding   GIFtS: 55
GCID: GC03M048701

NCK Interacting Protein With SH3 Domain

  See NCKIPSD-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NCK Interacting Protein With SH3 Domain1 2     WASP-Interacting SH3-Domain Protein2 3
AF3P212 3 5     90 KDa1
SPIN902 3 5     SH3 Protein Interacting With Nck1
Dia Interacting Protein1 2     DIP2
Diaphanous Protein Interacting Protein1 2     DIP12
Dia-Interacting Protein 12 3     ORF12
Wiskott-Aldrich Syndrome Protein-Interacting Protein2 3     WASLBP2
54 KDa VacA-Interacting Protein2 3     NCK-Interacting Protein With SH3 Domain2
54 KDa Vimentin-Interacting Protein2 3     SH3 Protein Interacting With Nck, 90 KDa2
90 KDa SH3 Protein Interacting With Nck2 3     AF3p213
VIP542 3     DIP-13
WISH2 3     Diaphanous Protein-Interacting Protein3
SH3 Adapter Protein SPIN902 3     

External Ids:    HGNC: 154861   Entrez Gene: 515172   Ensembl: ENSG000002136727   OMIM: 6066715   UniProtKB: Q9NZQ33   

Export aliases for NCKIPSD gene to outside databases

Previous GC identifers: GC03M048661 GC03M048675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCKIPSD Gene:
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal
transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into
sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related
leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid
leukemia gene. Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq,
Jul 2013)

GeneCards Summary for NCKIPSD Gene:
NCKIPSD (NCK interacting protein with SH3 domain) is a protein-coding gene. Diseases associated with NCKIPSD include wiskott-aldrich syndrome. GO annotations related to this gene include cytoskeletal protein binding and SH3 domain binding.

UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
Function: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1).
Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex
activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres
and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell
adhesion. Plays a role in angiogenesis

Gene Wiki entry for NCKIPSD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCKIPSD gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   ATF-2   E2F-2   c-Jun   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCKIPSD promoter sequence
   Search Chromatin IP Primers for NCKIPSD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCKIPSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

NCKIPSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCKIPSD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048701:  view genomic region     (about GC identifiers)

Start:
48,701,364 bp from pter      End:
48,723,797 bp from pter
Size:
22,434 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3 (See protein sequence)
Recommended Name: NCK-interacting protein with SH3 domain  
Size: 722 amino acids; 78960 Da
Subunit: Associates with the intermediate filaments, vimentin and desmin. Binds the first and third SH3 domains of
NCK. Binds the proline-rich domains of N-WASP through its SH3 domain (By similarity). Similarly, binds diaphanous
protein homolog 1 (DRF1). Binds the SH3 domains of GRB2 through its proline-rich domains. Interacts with
Helicobacter pylori toxin vacA. Isoform 4 interacts with FHOD1. Interacts with FASLG. Interacts with TMIGD2
Sequence caution: Sequence=BAG57476.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DFL5 Q6GU34 Q6SPF3 Q8TC10 Q9UGM8
Alternative splicing: 5 isoforms:  Q9NZQ3-1   Q9NZQ3-2   Q9NZQ3-3   Q9NZQ3-4   Q9NZQ3-5   (Found in a brain affected by Alzheimer disease. May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCKIPSD: NX_Q9NZQ3

Explore proteomics data for NCKIPSD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NCKIPSD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057537.1  NP_909119.1  

    ENSEMBL proteins: 
     ENSP00000389059   ENSP00000294129   ENSP00000396683   ENSP00000406442   ENSP00000409675  
     ENSP00000416144   ENSP00000408588   ENSP00000416904   ENSP00000342621  
    Reactome Protein details: Q9NZQ3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018556 DUF2013
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9NZQ3

    ProtoNet protein and cluster: Q9NZQ3

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with NCKIPSD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPN90_HUMAN, Q9NZQ3
    Function: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1).
    Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex
    activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres
    and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell
    adhesion. Plays a role in angiogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15095401
    GO:0008092cytoskeletal protein binding NAS10619843
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with NCKIPSD           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCKIPSD:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nckipsd):
     cellular  growth/size/body  nervous system  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with NCKIPSD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NCKIPSD: Nckipsdtm1Wkso Nckipsdtm1.2Toft

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCKIPSD
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    miRTarBase miRNAs that target NCKIPSD:
    hsa-mir-125a-5p (MIRT045772), hsa-let-7e-5p (MIRT051609), hsa-mir-1226-3p (MIRT036524), hsa-mir-148b-3p (MIRT019269)

    Block miRNA regulation of human, mouse, rat NCKIPSD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCKIPSD (see all 43):
    hsa-miR-4254 hsa-miR-1321 hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-124 hsa-miR-637 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNCKIPSD 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPN90_HUMAN, Q9NZQ3: Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature
    cardiac myocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005882intermediate filament NAS10619843
    GO:0008180colocalizes with COP9 signalosome IDA18850735

    Find genes that share ontologies with NCKIPSD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCKIPSD About    
    See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with NCKIPSD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NCKIPSD
        Regulation of actin dynamics for phagocytic cup formation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCKIPSD
    Interactions:

        GeneGlobe Interaction Network for NCKIPSD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCKIPSD (Q9NZQ31, 2, 3 ENSP000002941294) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110791 I2D: score=3 STRING: ENSP00000361423
    BAIAP2Q9UQB81, 2, 3, ENSP000003163384EBI-745080,EBI-525456 MINT-7219383 I2D: score=6 STRING: ENSP00000316338
    PALLDQ8WX932, 3, ENSP000002615094MINT-8109267 I2D: score=1 STRING: ENSP00000261509
    RAC1P630002, 3, ENSP000003484614MINT-7219402 I2D: score=1 STRING: ENSP00000348461
    FYNP062412, 3, ENSP000003576564MINT-8111559 I2D: score=3 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006607NLS-bearing protein import into nucleus TAS10648423
    GO:0007010cytoskeleton organization NAS10619843
    GO:0007165signal transduction TAS10648423
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with NCKIPSD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NCKIPSD (SPN90)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCKIPSD gene (2 alternative transcripts): 
    NM_016453.3  NM_184231.2  

    Unigene Cluster for NCKIPSD:

    NCK interacting protein with SH3 domain
    Hs.655006  [show with all ESTs]
    Unigene Representative Sequence: AJ242655
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416649 ENST00000294129(uc003cun.3 uc003cum.3) ENST00000413374
    ENST00000470006 ENST00000415281 ENST00000439518(uc010hkh.2) ENST00000454134
    ENST00000453349 ENST00000426678 ENST00000341520
    miRNA
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    hsa-miR-4254 hsa-miR-1321 hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-124 hsa-miR-637 hsa-miR-3116
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    Additional mRNA sequence: 

    AF178432.1 AF303581.1 AJ242655.2 AK294151.1 AL049430.1 AY453794.1 BC006255.2 BC016052.1 
    BC026280.1 

    9 DOTS entries:

    DT.442329  DT.100781728  DT.305127  DT.40271098  DT.97846133  DT.100781726  DT.99950774  DT.95075914 
    DT.92430019 

    1 AceView cDNA sequence:

    BF894800 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCKIPSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTTCC
    NCKIPSD Expression
    About this image

    NCKIPSD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCKIPSD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655006

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
    Tissue specificity: Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in
    placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NCKIPSD gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nckipsd1 , 5 NCK interacting protein with SH3 domain1, 5 87.11(n)1
    89.36(a)1
      9 (59.63 cM)5
    809871  NM_030729.41  NP_109654.21 
     1088083805 
    chicken
    (Gallus gallus)
    Aves NCKIPSD1 NCK interacting protein with SH3 domain 72.53(n)
    71.96(a)
      770439  XM_001233773.3  XP_001233774.3 
    lizard
    (Anolis carolinensis)
    Reptilia NCKIPSD6
    NCK interacting protein with SH3 domain
    65(a)
    1 ↔ 1
    2(164066029-164223893)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nckipsd1 NCK interacting protein with SH3 domain 66.19(n)
    66.91(a)
      100170192  NM_001129942.1  NP_001123414.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nckipsd1 NCK interacting protein with SH3 domain 62.75(n)
    59.25(a)
      100003986  XM_002666097.3  XP_002666143.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22586
    --
    28(a)
    1 ↔ 1
    X(7990610-7996087)


    ENSEMBL Gene Tree for NCKIPSD (if available)
    TreeFam Gene Tree for NCKIPSD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCKIPSD gene
    5 SIMAP similar genes for NCKIPSD using alignment to 7 protein entries:     SPN90_HUMAN (see all proteins):
    FNBP1L    GRAP    GRAPL    TXK    FYN

    Find genes that share paralogs with NCKIPSD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCKIPSD (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923770021,2
    --48710784(+) ATCACC/TGGAAC 2 -- ds50010--------
    rs343832231,2
    C--48710839(+) TACCAAA/-AAAAA 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs738304731,2
    C,F--48711199(+) AAGCTG/ACAGTG 2 -- ds50013Minor allele frequency- A:0.07WA CSA 121
    rs1846129271,2
    --48711414(+) CATGAA/GGCTCC 2 -- ut310--------
    rs1158647991,2
    C,F--48711627(+) GGATAC/TAGACC 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs1480421411,2
    --48711634(+) GACCAA/GGAGGG 2 -- ut310--------
    rs115457551,2
    C--48711659(-) GGCTGG/TACCAG 2 -- ut312Minor allele frequency- T:0.00NA 4
    rs1995339941,2
    --48712104(+) GGTCGA/GGTAGC 4 P L mis10--------
    rs178555161,2,,4
    H--48712167(+) AGAGGT/GACTCC 4 /Y /S mis14Minor allele frequency- G:0.00NS EA 420
    rs1875277771,2
    C--48712172(+) TACTCC/TATGCG 4 I M mis10--------

    HapMap Linkage Disequilibrium report for NCKIPSD (48701364 - 48723797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NCKIPSD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv523981CNV Loss19592680
    nsv818138CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCKIPSD
    DNA2.0 Custom Variant and Variant Library Synthesis for NCKIPSD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606671    OMIM disorders: --

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
  • Note=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia.
    Translocation t(3;11)(p21;q23) with KMT2A/MLL1

  • 1 disease for NCKIPSD:    
    About MalaCards
    wiskott-aldrich syndrome


    Find genes that share disorders with NCKIPSD           About GenesLikeMe

    2 Novoseek inferred disease relationships for NCKIPSD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 70.8 2 12853106 (1), 11157975 (1)
    leukemia 33.7 6 11241789 (2), 11697487 (2), 10648423 (1)


    Export disorders for NCKIPSD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCKIPSD gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with NCKIPSD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23). (PubMed id 10648423)1, 2, 3, 9 Sano K.... Nakamura H. (Blood 2000)
    2. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. (PubMed id 10619843)1, 2, 3 de Bernard M....Montecucco C. (EMBO J. 2000)
    3. Genomic organization, tissue expression and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia. (PubMed id 11241789)1, 2, 9 Hayakawa A.... Sano K. (Genes Chromosomes Cancer 2001)
    4. SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adapter protein that is developmentally regulated during cardiac myocyte differentiation. (PubMed id 11278500)1, 2, 9 Lim C.S.... Song W.K. (J. Biol. Chem. 2001)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    6. Identification of FHOD1-binding proteins and mechanisms of FHOD1- regulated actin dynamics. (PubMed id 15095401)1, 2 Westendorf J.J. and Koka S. (J. Cell. Biochem. 2004)
    7. mDia-interacting protein acts downstream of rho-mDia and modifies src activation and stress fiber formation. (PubMed id 11509578)1, 2 Satoh S. and Tominaga T. (J. Biol. Chem. 2001)
    8. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. (PubMed id 11157975)1, 9 Fukuoka M....Takenawa T. (J. Cell Biol. 2001)
    9. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. (PubMed id 17398099)1, 9 Eisenmann K.M....Alberts A.S. (Curr. Biol. 2007)
    10. SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons. (PubMed id 23765104)1 Cho I.H....Song W.K. (Cell. Mol. Life Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51517 HGNC: 15486 AceView: NCKIPSD Ensembl:ENSG00000213672 euGenes: HUgn51517
    ECgene: NCKIPSD H-InvDB: NCKIPSD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCKIPSD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCKIPSD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCKIPSD gene:
    Search GeneIP for patents involving NCKIPSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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