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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCKIPSD Gene

protein-coding   GIFtS: 51
GCID: GC03M048701

NCK interacting protein with SH3 domain
 Explore 7 diseases affiliated with
NCKIPSD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NCKIPSD    

Aliases
for NCKIPSD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NCK Interacting Protein With SH3 Domain1 2     90 KDa SH3 Protein Interacting With Nck2 3
AF3P211 2 3 5     DIP-12 3
SPIN901 2 3 5     VIP542 3
WISH1 2 3     SH3 Adapter Protein SPIN902 3
DIP11 2     WASP-Interacting SH3-Domain Protein2 3
ORF11 2     DIP2
WASLBP1 2     Dia Interacting Protein2
Dia-Interacting Protein 12 3     Diaphanous Protein Interacting Protein2
Diaphanous Protein-Interacting Protein2 3     NCK-Interacting Protein With SH3 Domain2
Wiskott-Aldrich Syndrome Protein-Interacting Protein2 3     SH3 Protein Interacting With Nck, 90 KDa2
54 KDa VacA-Interacting Protein2 3     AF3p213
54 KDa Vimentin-Interacting Protein2 3     

External Ids:    HGNC: 154861   Entrez Gene: 515172   Ensembl: ENSG000002136727   OMIM: 6066715   UniProtKB: Q9NZQ33   

Export aliases for NCKIPSD gene to outside databases

Previous GC identifers: GC03M048661 GC03M048675


Summaries
for NCKIPSD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NCKIPSD:
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction,
and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an
important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal
translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing
occurs in this locus and two transcript variants encoding distinct isoforms have been identified. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
Function: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1).
Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation
in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the
assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a
role in angiogenesis

Gene Wiki entry for NCKIPSD


Genomic Views
for NCKIPSD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCKIPSD gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   ATF-2   E2F-2   c-Jun   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCKIPSD promoter sequence
   Search SABiosciences Chromatin IP Primers for NCKIPSD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCKIPSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

NCKIPSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCKIPSD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048701:  view genomic region     (about GC identifiers)

Start:
 48,701,364 bp from pter      End:
 48,723,797 bp from pter
Size:
 22,434 bases      Orientation:
 minus strand

Proteins
for NCKIPSD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3 (See protein sequence)
Recommended Name: NCK-interacting protein with SH3 domain  
Size: 722 amino acids; 78960 Da
Subunit: Associates with the intermediate filaments, vimentin and desmin. Binds the first and third SH3 domains of NCK.
Binds the proline-rich domains of N-WASP through its SH3 domain (By similarity). Similarly, binds diaphanous protein
homolog 1 (DRF1). Binds the SH3 domains of GRB2 through its proline-rich domains. Interacts with Helicobacter pylori
toxin vacA. Isoform 4 interacts with FHOD1. Interacts with FASLG. Interacts with TMIGD2
Subcellular location: Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature
cardiac myocytes
Sequence caution: Sequence=BAG57476.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DFL5 Q6GU34 Q6SPF3 Q8TC10 Q9UGM8
Alternative splicing: 5 isoforms:  Q9NZQ3-1   Q9NZQ3-2   Q9NZQ3-3   Q9NZQ3-4   Q9NZQ3-5   (Found in a brain affected by Alzheimer disease. May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCKIPSD: NX_Q9NZQ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZQ3

    • NCKIPSD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_057537.1  NP_909119.1  

    ENSEMBL proteins: 
     ENSP00000389059   ENSP00000294129   ENSP00000396683   ENSP00000406442   ENSP00000409675  
     ENSP00000416144   ENSP00000408588   ENSP00000416904   ENSP00000342621  
    Reactome Protein details: Q9NZQ3
    Human Recombinant Protein Products: 
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    Novus Biologicals NCKIPSD Proteins
    Novus Biologicals NCKIPSD Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NCKIPSD

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament NAS10619843
    GO:0008180colocalizes with signalosome IDA18850735


    NCKIPSD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NCKIPSD

    Protein Domains /
    Families
    for NCKIPSD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NCKIPSD for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018556 DUF2013
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9NZQ3

    ProtoNet protein and cluster: Q9NZQ3

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
    Similarity: Contains 1 SH3 domain


    Function
    for NCKIPSD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
    Function: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1).
    Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation
    in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the
    assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a
    role in angiogenesis

    miRNA
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    hsa-miR-4254 hsa-miR-1321 hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-124 hsa-miR-637 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: NCKIPSD 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15095401
    GO:0008092cytoskeletal protein binding NAS10619843
    GO:0017124SH3 domain binding IEA--


    NCKIPSD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NCKIPSD:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for NCKIPSD: Nckipsdtm1Wkso Nckipsdtm1.2Toft
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nckipsd):
     cellular  growth/size  nervous system  no phenotypic analysis  reproductive system 

    NCKIPSD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NCKIPSD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80
    		Role of myosins in phagosome formation0.80
    		Branching and elongation of mother and daughter filaments0.29
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for NCKIPSD (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System



    NCKIPSD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCKIPSD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for NCKIPSD (Q9NZQ32, 3 ENSP000002941294) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110791 I2D: score=3 STRING: ENSP00000361423
    BAIAP2Q9UQB82, 3, ENSP000003163384MINT-7219383 I2D: score=6 STRING: ENSP00000316338
    PALLDQ8WX932, 3, ENSP000002615094MINT-8109267 I2D: score=1 STRING: ENSP00000261509
    RAC1P630002, 3, ENSP000003484614MINT-7219402 I2D: score=1 STRING: ENSP00000348461
    FYNP062412, 3, ENSP000003576564MINT-8111559 I2D: score=3 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006607NLS-bearing substrate import into nucleus TAS10648423
    GO:0007010cytoskeleton organization NAS10619843
    GO:0007165signal transduction TAS10648423


    NCKIPSD for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCKIPSD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCKIPSD
    Search CenterWatch for drugs/clinical trials and news about NCKIPSD / SPN90 

    Transcripts
    for NCKIPSD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCKIPSD gene (2 alternative transcripts): 
    NM_016453.2  NM_184231.1  

    Unigene Cluster for NCKIPSD:

    NCK interacting protein with SH3 domain
    Hs.655006  [show with all ESTs]
    Unigene Representative Sequence: AJ242655
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416649 ENST00000294129(uc003cun.3 uc003cum.3) ENST00000413374
    ENST00000470006 ENST00000415281 ENST00000439518(uc010hkh.2) ENST00000454134
    ENST00000453349 ENST00000426678 ENST00000341520

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate NCKIPSD (see all 43):
    hsa-miR-4254 hsa-miR-1321 hsa-miR-15a hsa-miR-301a hsa-miR-424 hsa-miR-124 hsa-miR-637 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: NCKIPSD 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF178432.1 AF303581.1 AJ242655.2 AK294151.1 AL049430.1 AY453794.1 BC006255.2 BC016052.1 
    BC026280.1 

    9 DOTS entries:

    DT.442329  DT.100781728  DT.305127  DT.40271098  DT.97846133  DT.100781726  DT.99950774  DT.95075914 
    DT.92430019 

    1 AceView cDNA sequence:

    BF894800 

    GeneLoc Exon Structure


    Expression
    for NCKIPSD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCKIPSD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATTTTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NCKIPSD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCKIPSD

    SOURCE GeneReport for Unigene cluster: Hs.655006

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
    Tissue specificity: Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta,
    lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen

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    In Situ
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    Orthologs
    for NCKIPSD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NCKIPSD gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nckipsd1 , 5 NCK interacting protein with SH3 domain1, 5 87.11(n)1
    89.36(a)1    		   9 (59.63 cM)5
    809871  NM_030729.41  NP_109654.21 
     1088083805 
    chicken
    (Gallus gallus)    		 Aves NCKIPSD1 NCK interacting protein with SH3 domain 72.39(n)
    71.82(a)    		   770439  XM_001233773.2  XP_001233774.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 70(a)
    65(a)
    		 possible ortholog
    possible ortholog
    		 2(164211587-164221585)
    2(164123246-164180556)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000039861 NCK-interacting protein with SH3 domain-like 62.22(n)
    58.97(a)    		   100003986  XM_002666097.2  XP_002666143.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG22581 CG2258 46.39(n)
    34.37(a)    		   31729  NM_132211.1  NP_572439.1 


    ENSEMBL Gene Tree for NCKIPSD (if available)
    TreeFam Gene Tree for NCKIPSD (if available) 

    Paralogs
    for NCKIPSD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NCKIPSD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 NCBI SNPs in NCKIPSD are shown (see all 278)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1923770021,2
    		--48710784(+) ATCACC/TGGAAC 2 -- ds50010--------
    rs666167021,2
    		C--48710840(+) TACCAAA/-AAAAA 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs738304731,2
    		C,--48711199(+) AAGCTG/ACAGTG 2 -- ds50013Minor allele frequency- A:0.07WA CSA 121
    rs1846129271,2
    		--48711414(+) CATGAA/GGCTCC 2 -- ut310--------
    rs1158647991,2
    		C,F,--48711627(+) GGATAC/TAGACC 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs1480421411,2
    		--48711634(+) GACCAA/GGAGGG 2 -- ut310--------
    rs115457551,2
    		C--48711659(-) GGCTGG/TACCAG 2 -- ut312Minor allele frequency- T:0.00NA 4
    rs1995339941,2
    		--48712104(+) GGTCGA/GGTAGC 4 P L mis10--------
    rs178555161,2
    		H--48712167(+) AGAGGT/GACTCC 4 /Y /S mis14Minor allele frequency- G:0.00NS EA 420
    rs1875277771,2
    		C,--48712172(+) TACTCC/TATGCG 4 I M mis10--------

    HapMap Linkage Disequilibrium report for NCKIPSD (48701364 - 48723797 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NCKIPSD
         1 CNV: 9448

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    Disorders / Diseases
    for NCKIPSD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NCKIPSD for disorders           About GeneDecksing

    OMIM gene information: 606671    OMIM disorders: --

    UniProtKB/Swiss-Prot: SPN90_HUMAN, Q9NZQ3
  • Note=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation
    • t(3;11)(p21;q23) with MLL

    7 diseases for NCKIPSD:    About MalaCards
    wiskott-aldrich syndrome    leukemia    lymphoid leukemia    alzheimer's disease
    neuronitis    pancreatic cancer    pancreatitis

    2 Novoseek disease relationships for NCKIPSD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 70.8 2 12853106 (1), 11157975 (1)
    leukemia 33.7 6 11241789 (2), 11697487 (2), 10648423 (1)


    Export disorders for NCKIPSD gene to outside databases

    Publications
    for NCKIPSD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCKIPSD gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with NCKIPSD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23). (PubMed id 10648423)1, 2, 3, 9 Sano K.... Nakamura H. (2000)
    2. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. (PubMed id 10619843)1, 2, 3 de Bernard M....Montecucco C. (2000)
    3. Genomic organization, tissue expression and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia. (PubMed id 11241789)1, 2, 9 Hayakawa A.... Sano K. (2001)
    4. SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adapter protein that is developmentally regulated during cardiac myocyte differentiation. (PubMed id 11278500)1, 2, 9 Lim C.S.... Song W.K. (2001)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    6. Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics. (PubMed id 15095401)1, 2 Westendorf J.J. and Koka S. (2004)
    7. mDia-interacting protein acts downstream of rho-mDia and modifies src activation and stress fiber formation. (PubMed id 11509578)1, 2 Satoh S. and Tominaga T. (2001)
    8. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. (PubMed id 11157975)1, 9 Fukuoka M....Takenawa T. (2001)
    9. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. (PubMed id 17398099)1, 9 Eisenmann K.M....Alberts A.S. (2007)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for NCKIPSD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing NCKIPSD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51517 HGNC: 15486 AceView: NCKIPSD Ensembl:ENSG00000213672 euGenes: HUgn51517
    ECgene: NCKIPSD H-InvDB: NCKIPSD

    Other Databases showing NCKIPSD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NCKIPSD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCKIPSD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCKIPSD Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NCKIPSD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCKIPSD gene:
    Search GeneIP for patents involving NCKIPSD

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