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Aliases for NCKAP5L Gene

Aliases for NCKAP5L Gene

  • NCK Associated Protein 5 Like 2 3 5
  • KIAA1602 2 3 4
  • Centrosomal Protein Of 169 KDa 3 4
  • NCKAP5-Like 3 4
  • Cep169 3 4
  • Nck-Associated Protein 5-Like 3
  • FP1193 3

External Ids for NCKAP5L Gene

Previous HGNC Symbols for NCKAP5L Gene

  • KIAA1602

Previous GeneCards Identifiers for NCKAP5L Gene

  • GC12M048472
  • GC12M050185
  • GC12M047216

Summaries for NCKAP5L Gene

GeneCards Summary for NCKAP5L Gene

NCKAP5L (NCK Associated Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is NCKAP5.

UniProtKB/Swiss-Prot for NCKAP5L Gene

  • Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCKAP5L Gene

Genomics for NCKAP5L Gene

Regulatory Elements for NCKAP5L Gene

Enhancers for NCKAP5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F049669 1.6 FANTOM5 Ensembl ENCODE 11.3 +155.9 155924 7.2 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A YBX1 ZNF121 ELK1 ZNF207 FMNL3 TMBIM6 NCKAP5L FAM186B RNU6-834P TUBA1C ENSG00000257464 SPATS2 MCRS1 TUBA1A
GH12F049867 1.4 Ensembl ENCODE 10.9 -40.0 -39953 3.4 PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF302 ZNF143 FOS DEK NCKAP5L FMNL3 TMBIM6 FAIM2 RPL35AP28 GC12M049898
GH12F049776 1.2 Ensembl ENCODE 11.9 +52.0 51950 1.2 HDGF TBP CBX3 KLF17 ARID4B ZNF2 RAD21 ZEB1 RFX5 ZNF335 NCKAP5L FMNL3 TMBIM6 MCRS1 LSM6P2 GC12M049802
GH12F049748 1.2 Ensembl ENCODE 11.1 +78.6 78560 3.2 HDGF PKNOX1 ATF1 FEZF1 ZNF2 ZNF416 YY2 REST ZNF518A ATF4 TMBIM6 NCKAP5L FMNL3 TUBA1C DNAJC22 PIR62478 PIR31272
GH12F049740 1.2 ENCODE 10.4 +85.8 85833 4.3 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DDX23 TMBIM6 FMNL3 PRKAG1 LOC390314 MCRS1 NCKAP5L CACNB3 SPATS2 PIR62478
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCKAP5L on UCSC Golden Path with GeneCards custom track

Promoters for NCKAP5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088330 650 2201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for NCKAP5L Gene

Chromosome:
12
Start:
49,791,139 bp from pter
End:
49,828,750 bp from pter
Size:
37,612 bases
Orientation:
Minus strand

Genomic View for NCKAP5L Gene

Genes around NCKAP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCKAP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCKAP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCKAP5L Gene

Proteins for NCKAP5L Gene

  • Protein details for NCKAP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCH0-NCK5L_HUMAN
    Recommended name:
    Nck-associated protein 5-like
    Protein Accession:
    Q9HCH0
    Secondary Accessions:
    • Q2TB26
    • Q71RH1
    • Q8N4W1
    • Q96HX2

    Protein attributes for NCKAP5L Gene

    Size:
    1330 amino acids
    Molecular mass:
    139013 Da
    Quaternary structure:
    • Homodimer (PubMed:26482847). Interacts with CDK5RAP2 (PubMed:26485573). Interacts with MAPRE1 (PubMed:26485573). Interacts with beta-tubulin (PubMed:26482847).
    SequenceCaution:
    • Sequence=AAQ15202.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NCKAP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCKAP5L Gene

Post-translational modifications for NCKAP5L Gene

  • CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCKAP5L Gene

No data available for DME Specific Peptides for NCKAP5L Gene

Domains & Families for NCKAP5L Gene

Protein Domains for NCKAP5L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCKAP5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCKAP5L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NCKAP5L Gene

Function for NCKAP5L Gene

Molecular function for NCKAP5L Gene

UniProtKB/Swiss-Prot Function:
Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

Gene Ontology (GO) - Molecular Function for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view
genes like me logo Genes that share phenotypes with NCKAP5L: view

Animal Model Products

miRNA for NCKAP5L Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCKAP5L Gene

Localization for NCKAP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCKAP5L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to microtubule plus ends (PubMed:26485573, PubMed:26482847). Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis (PubMed:26549230). {ECO:0000269 PubMed:26482847, ECO:0000269 PubMed:26485573, ECO:0000269 PubMed:26549230}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCKAP5L gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 26485573
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NCKAP5L: view

Pathways & Interactions for NCKAP5L Gene

SuperPathways for NCKAP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 26485573
GO:0007019 microtubule depolymerization IMP 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view

No data available for Pathways by source and SIGNOR curated interactions for NCKAP5L Gene

Transcripts for NCKAP5L Gene

Unigene Clusters for NCKAP5L Gene

NCK-associated protein 5-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP5L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for NCKAP5L Gene

GeneLoc Exon Structure for
NCKAP5L
ECgene alternative splicing isoforms for
NCKAP5L

Expression for NCKAP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCKAP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCKAP5L Gene

This gene is overexpressed in Brain (60.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCKAP5L Gene



Protein tissue co-expression partners for NCKAP5L Gene

NURSA nuclear receptor signaling pathways regulating expression of NCKAP5L Gene:

NCKAP5L

SOURCE GeneReport for Unigene cluster for NCKAP5L Gene:

Hs.143067
genes like me logo Genes that share expression patterns with NCKAP5L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCKAP5L Gene

Orthologs for NCKAP5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCKAP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCKAP5L 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia NCKAP5L 34 35
  • 89.34 (n)
dog
(Canis familiaris)
Mammalia NCKAP5L 34 35
  • 88.64 (n)
mouse
(Mus musculus)
Mammalia Nckap5l 34 16 35
  • 85.13 (n)
rat
(Rattus norvegicus)
Mammalia Nckap5l 34
  • 84.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NCKAP5L 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCKAP5L 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nckap5l 34
  • 55.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20266 34
zebrafish
(Danio rerio)
Actinopterygii NCKAP5L 35
  • 25 (a)
OneToOne
Species where no ortholog for NCKAP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCKAP5L Gene

ENSEMBL:
Gene Tree for NCKAP5L (if available)
TreeFam:
Gene Tree for NCKAP5L (if available)

Paralogs for NCKAP5L Gene

Paralogs for NCKAP5L Gene

genes like me logo Genes that share paralogs with NCKAP5L: view

Variants for NCKAP5L Gene

Sequence variations from dbSNP and Humsavar for NCKAP5L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1031476 -- 49,824,650(+) GAAGG(A/G)TAAAC intron-variant
rs1031477 -- 49,824,861(+) AGCTG(C/T)TTTTC intron-variant
rs1075366 -- 49,798,226(+) CTTTT(C/T)TTGGC intron-variant
rs1077498 -- 49,801,607(-) TGCCT(C/T)GGGTG intron-variant
rs1077499 -- 49,801,494(-) GGTGT(A/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCKAP5L Gene

Variant ID Type Subtype PubMed ID
nsv522972 CNV gain 19592680

Variation tolerance for NCKAP5L Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.37; 92.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCKAP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCKAP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCKAP5L Gene

Disorders for NCKAP5L Gene

Relevant External Links for NCKAP5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCKAP5L

No disorders were found for NCKAP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCKAP5L Gene

Publications for NCKAP5L Gene

  1. Cep169, a novel microtubule plus-end-tracking centrosomal protein, binds to CDK5RAP2 and regulates microtubule stability. (PMID: 26485573) Mori Y. … Terada Y. (PLoS ONE 2015) 3 4 64
  2. Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis. (PMID: 26549230) Mori Y. … Terada Y. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for NCKAP5L Gene

Sources for NCKAP5L Gene

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