Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCKAP5L Gene

Aliases for NCKAP5L Gene

  • NCK Associated Protein 5 Like 2 3
  • KIAA1602 2 3 4
  • Centrosomal Protein Of 169 KDa 3 4
  • NCKAP5-Like 3 4
  • Cep169 3 4
  • NCK-Associated Protein 5-Like 5
  • FP1193 3

External Ids for NCKAP5L Gene

Previous HGNC Symbols for NCKAP5L Gene

  • KIAA1602

Previous GeneCards Identifiers for NCKAP5L Gene

  • GC12M048472
  • GC12M050185
  • GC12M047216

Summaries for NCKAP5L Gene

GeneCards Summary for NCKAP5L Gene

NCKAP5L (NCK Associated Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is NCKAP5.

UniProtKB/Swiss-Prot for NCKAP5L Gene

  • Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCKAP5L Gene

Genomics for NCKAP5L Gene

Regulatory Elements for NCKAP5L Gene

Promoters for NCKAP5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCKAP5L on UCSC Golden Path with GeneCards custom track

Genomic Location for NCKAP5L Gene

Chromosome:
12
Start:
49,791,139 bp from pter
End:
49,828,750 bp from pter
Size:
37,612 bases
Orientation:
Minus strand

Genomic View for NCKAP5L Gene

Genes around NCKAP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCKAP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCKAP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCKAP5L Gene

Proteins for NCKAP5L Gene

  • Protein details for NCKAP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCH0-NCK5L_HUMAN
    Recommended name:
    Nck-associated protein 5-like
    Protein Accession:
    Q9HCH0
    Secondary Accessions:
    • Q2TB26
    • Q71RH1
    • Q8N4W1
    • Q96HX2

    Protein attributes for NCKAP5L Gene

    Size:
    1330 amino acids
    Molecular mass:
    139013 Da
    Quaternary structure:
    • Homodimer (PubMed:26482847). Interacts with CDK5RAP2 (PubMed:26485573). Interacts with MAPRE1 (PubMed:26485573). Interacts with beta-tubulin (PubMed:26482847).
    SequenceCaution:
    • Sequence=AAQ15202.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NCKAP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCKAP5L Gene

Proteomics data for NCKAP5L Gene at MOPED

Post-translational modifications for NCKAP5L Gene

  • CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCKAP5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCKAP5L Gene

Domains & Families for NCKAP5L Gene

Protein Domains for NCKAP5L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCKAP5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCKAP5L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NCKAP5L Gene

Function for NCKAP5L Gene

Molecular function for NCKAP5L Gene

UniProtKB/Swiss-Prot Function:
Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).
genes like me logo Genes that share phenotypes with NCKAP5L: view

Animal Model Products

CRISPR Products

miRNA for NCKAP5L Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCKAP5L Gene

Localization for NCKAP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCKAP5L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to microtubule plus ends (PubMed:26485573, PubMed:26482847). Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis (PubMed:26549230). {ECO:0000269 PubMed:26482847, ECO:0000269 PubMed:26485573, ECO:0000269 PubMed:26549230}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCKAP5L Gene COMPARTMENTS Subcellular localization image for NCKAP5L gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035371 microtubule plus-end IDA 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view

Pathways & Interactions for NCKAP5L Gene

SuperPathways for NCKAP5L Gene

No Data Available

Interacting Proteins for NCKAP5L Gene

Gene Ontology (GO) - Biological Process for NCKAP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IMP 26485573
genes like me logo Genes that share ontologies with NCKAP5L: view

No data available for Pathways by source and SIGNOR curated interactions for NCKAP5L Gene

Drugs & Compounds for NCKAP5L Gene

No Compound Related Data Available

Transcripts for NCKAP5L Gene

Unigene Clusters for NCKAP5L Gene

NCK-associated protein 5-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP5L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for NCKAP5L Gene

GeneLoc Exon Structure for
NCKAP5L
ECgene alternative splicing isoforms for
NCKAP5L

Expression for NCKAP5L Gene

mRNA expression in normal human tissues for NCKAP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCKAP5L Gene

This gene is overexpressed in Brain (60.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCKAP5L Gene



SOURCE GeneReport for Unigene cluster for NCKAP5L Gene Hs.143067

genes like me logo Genes that share expression patterns with NCKAP5L: view

Protein tissue co-expression partners for NCKAP5L Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCKAP5L Gene

Orthologs for NCKAP5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCKAP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCKAP5L 36
  • 99 (a)
OneToOne
NCKAP5L 35
  • 99.15 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia NCKAP5L 35
  • 89.34 (n)
  • 90.02 (a)
NCKAP5L 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCKAP5L 36
  • 90 (a)
OneToOne
NCKAP5L 35
  • 88.64 (n)
  • 90.73 (a)
mouse
(Mus musculus)
Mammalia Nckap5l 36
  • 87 (a)
OneToOne
Nckap5l 16
Nckap5l 35
  • 85.13 (n)
  • 87.76 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia NCKAP5L 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nckap5l 35
  • 84.13 (n)
  • 86.24 (a)
lizard
(Anolis carolinensis)
Reptilia NCKAP5L 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20266 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nckap5l 35
  • 55.2 (n)
  • 50.88 (a)
zebrafish
(Danio rerio)
Actinopterygii NCKAP5L 36
  • 25 (a)
OneToOne
Species with no ortholog for NCKAP5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCKAP5L Gene

ENSEMBL:
Gene Tree for NCKAP5L (if available)
TreeFam:
Gene Tree for NCKAP5L (if available)

Paralogs for NCKAP5L Gene

Paralogs for NCKAP5L Gene

genes like me logo Genes that share paralogs with NCKAP5L: view

Variants for NCKAP5L Gene

Sequence variations from dbSNP and Humsavar for NCKAP5L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1031476 -- 49,824,650(+) GAAGG(A/G)TAAAC intron-variant
rs2336448 -- 49,818,845(-) CTCCA(A/G)TGGTG intron-variant
rs4075681 -- 49,820,854(-) cagga(A/G)cagaa intron-variant
rs2290442 -- 49,791,551(-) AGCCC(C/T)CCAGT downstream-variant-500B, utr-variant-3-prime
rs2720287 -- 49,807,665(-) AAGGA(A/G)GATAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCKAP5L Gene

Variant ID Type Subtype PubMed ID
nsv522972 CNV Gain 19592680

Variation tolerance for NCKAP5L Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.37; 92.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCKAP5L Gene

HapMap Linkage Disequilibrium report
NCKAP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCKAP5L Gene

Disorders for NCKAP5L Gene

Relevant External Links for NCKAP5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCKAP5L

No disorders were found for NCKAP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCKAP5L Gene

Publications for NCKAP5L Gene

  1. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NCKAP5L Gene

Sources for NCKAP5L Gene

Back to Top

Content