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Aliases for NCKAP5 Gene

Aliases for NCKAP5 Gene

  • NCK Associated Protein 5 2 3
  • Peripheral Clock Protein 2 4
  • NAP-5 3 4
  • NAP5 3 4
  • Peripheral Clock Protein 2 3
  • NCK-Associated Protein 5 5
  • ERIH1 3
  • ERIH2 3
  • ERIH 4

External Ids for NCKAP5 Gene

Previous GeneCards Identifiers for NCKAP5 Gene

  • GC02M133146
  • GC02M133429
  • GC02M125422

Summaries for NCKAP5 Gene

GeneCards Summary for NCKAP5 Gene

NCKAP5 (NCK Associated Protein 5) is a Protein Coding gene. Diseases associated with NCKAP5 include hypersomnia. An important paralog of this gene is NCKAP5L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCKAP5 Gene

Genomics for NCKAP5 Gene

Genomic Location for NCKAP5 Gene

Chromosome:
2
Start:
132,671,788 bp from pter
End:
133,674,923 bp from pter
Size:
1,003,136 bases
Orientation:
Minus strand

Genomic View for NCKAP5 Gene

Genes around NCKAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCKAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCKAP5 Gene

No data available for Regulatory Elements for NCKAP5 Gene

Proteins for NCKAP5 Gene

  • Protein details for NCKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14513-NCKP5_HUMAN
    Recommended name:
    Nck-associated protein 5
    Protein Accession:
    O14513
    Secondary Accessions:
    • B8ZZL0
    • Q29SS9
    • Q29ST0
    • Q2NL90
    • Q6ZVE2
    • Q8NAS3

    Protein attributes for NCKAP5 Gene

    Size:
    1909 amino acids
    Molecular mass:
    208537 Da
    Quaternary structure:
    • Interacts with the SH3-containing region of the adapter protein NCK.
    SequenceCaution:
    • Sequence=BAA22433.1; Type=Frameshift; Positions=856, 877, 920, 926, 957, 967; Evidence={ECO:0000305}; Sequence=BAC85920.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NCKAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCKAP5 Gene

Proteomics data for NCKAP5 Gene at MOPED

Post-translational modifications for NCKAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCKAP5 Gene

No data available for DME Specific Peptides for NCKAP5 Gene

Domains & Families for NCKAP5 Gene

Protein Domains for NCKAP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCKAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCKAP5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NCKAP5 Gene

Function for NCKAP5 Gene

Phenotypes for NCKAP5 Gene

GenomeRNAi human phenotypes for NCKAP5:
genes like me logo Genes that share phenotypes with NCKAP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCKAP5 Gene

Localization for NCKAP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCKAP5 Gene COMPARTMENTS Subcellular localization image for NCKAP5 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NCKAP5 Gene

Pathways & Interactions for NCKAP5 Gene

SuperPathways for NCKAP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCKAP5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NCKAP5 Gene

Drugs & Compounds for NCKAP5 Gene

No Compound Related Data Available

Transcripts for NCKAP5 Gene

Unigene Clusters for NCKAP5 Gene

NCK-associated protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP5 Gene

No ASD Table

Relevant External Links for NCKAP5 Gene

GeneLoc Exon Structure for
NCKAP5
ECgene alternative splicing isoforms for
NCKAP5

Expression for NCKAP5 Gene

mRNA expression in normal human tissues for NCKAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCKAP5 Gene

This gene is overexpressed in Lung (x4.2).

Protein differential expression in normal tissues from HIPED for NCKAP5 Gene

This gene is overexpressed in Cerebrospinal fluid (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCKAP5 Gene



SOURCE GeneReport for Unigene cluster for NCKAP5 Gene Hs.537329

mRNA Expression by UniProt/SwissProt for NCKAP5 Gene

O14513-NCKP5_HUMAN
Tissue specificity: Expressed in fetal and adult brain, leukocytes and fetal fibroblasts.
genes like me logo Genes that share expression patterns with NCKAP5: view

Protein tissue co-expression partners for NCKAP5 Gene

Primer Products

In Situ Assay Products

Orthologs for NCKAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCKAP5 35
  • 97.23 (n)
  • 96.98 (a)
cow
(Bos Taurus)
Mammalia NCKAP5 36
  • 73 (a)
OneToOne
NCKAP5 35
  • 82.68 (n)
  • 76.74 (a)
dog
(Canis familiaris)
Mammalia NCKAP5 35
  • 84.03 (n)
  • 78.43 (a)
NCKAP5 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nckap5 16
Nckap5 36
  • 64 (a)
OneToOne
Nckap5 35
  • 75.51 (n)
  • 67.62 (a)
oppossum
(Monodelphis domestica)
Mammalia NCKAP5 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nckap5 35
  • 75.71 (n)
  • 67.9 (a)
chicken
(Gallus gallus)
Aves NCKAP5 35
  • 63.13 (n)
  • 55.33 (a)
NCKAP5 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCKAP5 36
  • 42 (a)
OneToOne
Species with no ortholog for NCKAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NCKAP5 Gene

ENSEMBL:
Gene Tree for NCKAP5 (if available)
TreeFam:
Gene Tree for NCKAP5 (if available)

Paralogs for NCKAP5 Gene

Paralogs for NCKAP5 Gene

genes like me logo Genes that share paralogs with NCKAP5: view

Variants for NCKAP5 Gene

Sequence variations from dbSNP and Humsavar for NCKAP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17325719 - 132,785,012(+) AAGGA(C/G)TTTTC intron-variant, reference, missense
rs12611515 - 132,784,002(+) GGAGA(C/T)GGACC intron-variant, reference, missense
rs12691830 - 132,783,881(+) CAGAA(A/G)TTCCT intron-variant, reference, missense
rs16841277 - 132,783,534(+) ATCAT(A/T)CAATT intron-variant, reference, missense
rs13016342 - 132,783,032(+) GGTGT(G/T)GTTTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NCKAP5 Gene

Variant ID Type Subtype PubMed ID
esv4378 CNV Complex 18987735
nsv875137 CNV Gain 21882294
nsv875138 CNV Gain 21882294
nsv834379 CNV Gain 17160897
esv2677357 CNV Deletion 23128226
esv2720835 CNV Deletion 23290073
nsv441785 CNV CNV 18776908
nsv821729 CNV Loss 20364138
nsv2931 CNV Loss 18451855
esv7088 CNV Loss 19470904
dgv733e199 CNV Deletion 23128226
esv2677853 CNV Deletion 23128226
esv2670272 CNV Deletion 23128226
esv26071 CNV Loss 19812545
esv2664567 CNV Deletion 23128226
nsv834381 CNV Gain 17160897
nsv834382 CNV Loss 17160897
nsv528037 CNV Gain 19592680
nsv875139 CNV Loss 21882294
nsv470487 CNV Loss 18288195
nsv875140 CNV Loss 21882294
nsv521538 CNV Loss 19592680
nsv459452 CNV Loss 19166990
esv2592119 CNV Deletion 19546169
esv2340909 CNV Deletion 18987734
esv3903 CNV Deletion 18987735
esv2720836 CNV Deletion 23290073
esv998316 CNV Deletion 20482838
esv8474 CNV Loss 19470904
nsv834383 CNV Loss 17160897
nsv459463 CNV Loss 19166990
esv269749 CNV Insertion 20981092
nsv526139 CNV Loss 19592680
nsv516915 CNV Gain 19592680
nsv834384 CNV Gain 17160897
nsv2933 CNV Insertion 18451855
nsv522324 CNV Loss 19592680
esv2656964 CNV Deletion 23128226
esv2677288 CNV Deletion 23128226
esv2675555 CNV Deletion 23128226
nsv508871 CNV Insertion 20534489
nsv507034 CNV Insertion 20534489
esv2720837 CNV Deletion 23290073
nsv516644 CNV Gain+Loss 19592680

Variation tolerance for NCKAP5 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.33; 98.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCKAP5 Gene

HapMap Linkage Disequilibrium report
NCKAP5
Human Gene Mutation Database (HGMD)
NCKAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCKAP5 Gene

Disorders for NCKAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCKAP5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypersomnia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NCKAP5

Genetic Association Database (GAD)
NCKAP5
Human Genome Epidemiology (HuGE) Navigator
NCKAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCKAP5
genes like me logo Genes that share disorders with NCKAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCKAP5 Gene

Publications for NCKAP5 Gene

  1. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K. … Takenawa T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  3. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. (PMID: 23646285) Khor S.S. … Tokunaga K. (PeerJ 2013) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 3

Products for NCKAP5 Gene

Sources for NCKAP5 Gene

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