Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCKAP1L Gene

protein-coding   GIFtS: 53
GCID: GC12P054891

NCK-associated protein 1-like

(Previous name: hematopoietic protein 1 )
(Previous symbol: HEM1)
 Explore 4 diseases affiliated with
NCKAP1L via our new
 Human Malady Compendium 
Biological research products
for NCKAP1L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NCK-Associated Protein 1-Like1 2
HEM11 2 3 5
Hematopoietic Protein 11 2 3
Membrane-Associated Protein HEM-12 3

External Ids:    HGNC: 48621   Entrez Gene: 30712   Ensembl: ENSG000001233387   OMIM: 1411805   UniProtKB: P551603   

Export aliases for NCKAP1L gene to outside databases

Previous GC identifers: GC12P053178 GC12P051930


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCKAP1L:
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from
invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of
the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants.
Alternatively spliced transcript variants encoding different isoforms have been found.(provided by RefSeq, May 2010)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCKAP1L gene promoter:
         TBP   Pax-6   AREB6   POU2F1   FOXJ2 (long isoform)   POU2F1a   TFIID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCKAP1L promoter sequence
   Search SABiosciences Chromatin IP Primers for NCKAP1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCKAP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.1

NCKAP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCKAP1L gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054891:  view genomic region     (about GC identifiers)

Start:
54,891,495 bp from pter      End:
54,937,726 bp from pter
Size:
46,232 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCKPL_HUMAN, P55160 (See protein sequence)
Recommended Name: Nck-associated protein 1-like  
Size: 1127 amino acids; 128153 Da
Subcellular location: Cell membrane; Single-pass membrane protein; Cytoplasmic side (Probable)
Sequence caution: Sequence=AAA35964.1; Type=Erroneous initiation;
Secondary accessions: B4DUT5 Q52LW0
Alternative splicing: 2 isoforms:  P55160-1   P55160-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCKAP1L: NX_P55160

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55160

  • NCKAP1L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171905.1  NP_005328.2  

    ENSEMBL proteins: 
     ENSP00000293373   ENSP00000447246   ENSP00000445596   ENSP00000447444  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NCKAP1L 
    GenScript Custom Purified and Recombinant Proteins Services for NCKAP1L
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NCKAP1L

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005829cytosol IDA16417406
    GO:0005887integral to plasma membrane NAS1932118
    GO:0016020membrane TAS1932118
    GO:0031209SCAR complex IDA16417406


    NCKAP1L for ontologies           About GeneDecksing



    NCKAP1L Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NCKAP1L 
    GenScript Custom Superior Antibodies Services for NCKAP1L
    Novus Biologicals NCKAP1L Antibodies
    Search for Antibodies for NCKAP1L at Abcam  
    Uscn Antibodies for NCKAP1L
    Search ThermoFisher Antibodies for NCKAP1L

    Assay Products for NCKAP1L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCKAP1L
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NCKAP1L


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NCKAP1L for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019137 Nck-associated_protein-1

    Graphical View of Domain Structure for InterPro Entry P55160

    ProtoNet protein and cluster: P55160

    UniProtKB/Swiss-Prot: NCKPL_HUMAN, P55160
    Similarity: Belongs to the HEM-1/HEM-2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NCKAP1L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCKAP1L
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NCKAP1L (see all 11):
    hsa-miR-194* hsa-miR-99a* hsa-miR-99b* hsa-miR-1245 hsa-miR-3159 hsa-miR-889 hsa-miR-3682-3p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidNCKAP1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCKAP1L (see all 7)
    OriGene shRNA RFP: NCKAP1L
    OriGene siRNA: NCKAP1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCKAP1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCKAP1L

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NCKAP1L (NM_005337)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCKAP1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCKAP1L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NCKAP1L
    Search LifeMap BioReagents cell lines for NCKAP1L

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCKAP1L

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16417406
    GO:0030295protein kinase activator activity IMP16417406
    GO:0030675Rac GTPase activator activity IMP16417406
    GO:0032403protein complex binding IDA16417406


    NCKAP1L for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for NCKAP1L:
     Decreased BPV1 E2 protein expr  Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a  Increased S DNA content 

    Animal Models:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nckap1l):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  other  renal/urinary system  reproductive system 
     respiratory system 

    NCKAP1L for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.58

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NCKAP1L):
        Regulation of actin cytoskeleton


    NCKAP1L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCKAP1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for NCKAP1L (P551602, 3 ENSP000002933734) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAS7O608612, 3, ENSP000003226084MINT-72921 I2D: score=3 STRING: ENSP00000322608
    PRPF40AO754003I2D: score=2 
    RAC2ENSP000002490714STRING: ENSP00000249071
    RAC3ENSP000003042834STRING: ENSP00000304283
    WASF1ENSP000003524254STRING: ENSP00000352425
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis ISS--
    GO:0002262myeloid cell homeostasis ISS--
    GO:0006461protein complex assembly ISS--
    GO:0030011maintenance of cell polarity IMP16417406
    GO:0030593neutrophil chemotaxis IDA16417406


    NCKAP1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCKAP1L
    Search CenterWatch for drugs/clinical trials and news about NCKAP1L / NCKPL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCKAP1L gene (2 alternative transcripts): 
    NM_001184976.1  NM_005337.4  

    Unigene Cluster for NCKAP1L:

    NCK-associated protein 1-like
    Hs.182014  [show with all ESTs]
    Unigene Representative Sequence: NM_005337
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293373(uc001sgc.4 uc010sox.2 uc010soy.2) ENST00000548221
    ENST00000547500 ENST00000545638 ENST00000552211 ENST00000548916 ENST00000549451
    ENST00000548980

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NCKAP1L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCKAP1L
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NCKAP1L (see all 11):
    hsa-miR-194* hsa-miR-99a* hsa-miR-99b* hsa-miR-1245 hsa-miR-3159 hsa-miR-889 hsa-miR-3682-3p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidNCKAP1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCKAP1L (see all 7)
    OriGene shRNA RFP: NCKAP1L
    OriGene siRNA: NCKAP1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCKAP1L
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NCKAP1L (NM_005337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCKAP1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCKAP1L 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCKAP1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCKAP1L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCKAP1L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCKAP1L

    Additional cDNA sequence: 

    AK300783.1 AK314012.1 BC001604.2 BC064997.1 BC084547.1 BC093769.2 BC093771.1 M58285.1 

    12 DOTS entries:

    DT.110756  DT.95163588  DT.100841504  DT.86859689  DT.95163589  DT.92016724  DT.100694560  DT.100778358 
    DT.404958  DT.65284815  DT.95241684  DT.98082923 

    24/183 AceView cDNA sequences (see all 183):

    BG389488 AW445205 CA390313 BG256761 AI655955 BX395542 NM_005337 CR600496 
    BQ433466 BX482901 AI521554 CF121737 BX482767 AW452490 AI357311 AA864728 
    AL119153 CB054402 AI696806 BU630166 CN478513 BF001814 BG259380 BP344751 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP1L (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                          -                             -                                               -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32
    SP1:        -                                                     -                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NCKAP1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCKAP1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGAATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NCKAP1L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NCKAP1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCKAP1L

    SOURCE GeneReport for Unigene cluster: Hs.182014

    UniProtKB/Swiss-Prot: NCKPL_HUMAN, P55160
    Tissue specificity: Expressed only in cells of hematopoietic origin

        SABiosciences Custom PCR Arrays for NCKAP1L
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCKAP1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCKAP1L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCKAP1L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCKAP1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCKAP1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCKAP1L gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nckap1l1 , 5 NCK associated protein 1 like1, 5 89.68(n)1
    94.85(a)1
      15 (58.96 cM)5
    1058551  NM_153505.41  NP_705725.11 
     1034538255 
    chicken
    (Gallus gallus)
    Aves NCKAP1L1 NCK-associated protein 1-like 71.22(n)
    72.23(a)
      425499  NM_001031339.1  NP_001026510.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    71(a)
    69(a)
    many → 1
    many → 1
    GL343252.1(406986-470577)
    GL343252.1(359647-399666)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261032 Transcribed sequence with weak similarity to protein more 74.26(n)    CD604658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hem6
    HEM-protein
    48(a)
    1 → many
    3L(22277454-22281295)
    worm
    (Caenorhabditis elegans)
    Secernentea gex-36
    Membrane-associated protein gex-3
    36(a)
    1 → many
    IV(12404407-12408665)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GRL6
    protein NAP1
    16(a)
    1 → many
    2(14795715-14803937)
    rice
    (Oryza sativa)
    Liliopsida --
    NAP1, putative, expressed
    17(a)
    1 → many
    8(27274982-27287820)


    ENSEMBL Gene Tree for NCKAP1L (if available)
    TreeFam Gene Tree for NCKAP1L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCKAP1L gene
    NCKAP12  
    18/109 SIMAP similar genes for NCKAP1L using alignment to 6 protein entries:     NCKPL_HUMAN (see all proteins) (see all similar genes):
    ZNF211    ARIH1    KIAA1651    ADCK1    EIF3G    UTY
    pp12301    ARL6IP5    CCNJL    IDNK    KIAA0101    SLMO1
    ZMAT1    C1orf143    PFKFB3    PPP5D1    PUS1    SYT14

    NCKAP1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 NCBI SNPs in NCKAP1L are shown (see all 810    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152426651,2
    F,--54889686(+) GATACG/AGAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs171127831,2
    C,F,H,--54889698(+) GGGAAT/AGATTA 1 -- us2k1 tfbs39Minor allele frequency- A:0.06NA NS EA WA 800
    rs1477030841,2
    --54889837(+) GTTACA/GGAGTT 1 -- us2k10--------
    rs1174392371,2
    --54889908(+) TTAAGG/CGTGAT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs37823991,2
    C,A,H,--54889939(+) TCTTGA/GTTAAT 1 -- us2k14Minor allele frequency- G:0.11CSA WA NA EA 360
    rs1408366381,2
    --54890015(+) ATTTAC/TTGAGT 1 -- us2k10--------
    rs177257371,2
    C,F,H,--54890140(+) AGACTC/TGCCTA 1 -- us2k126Minor allele frequency- T:0.10NA NS EA WA 2910
    rs1423126151,2
    --54890198(+) CATCCA/GTAAAT 1 -- us2k10--------
    rs123009651,2
    H--54890328(+) gggtcC/Ttaaga 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1896034421,2
    --54890393(+) GAGAAG/TTACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCKAP1L (54891495 - 54937726 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NCKAP1L: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCKAP1L
    DNA2.0 Custom Variant and Variant Library Synthesis for NCKAP1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NCKAP1L for disorders           About GeneDecksing

    OMIM gene information: 141180    OMIM disorders: --

    4 diseases for NCKAP1L:    About MalaCards
    rectum cancer    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia

    1 disease from the University of Copenhagen DISEASES database for NCKAP1L:
    Hypochromic anemia

    Export disorders for NCKAP1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCKAP1L gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NCKAP1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis. (PubMed id 7643388)1, 2 Baumgartner S.... Hromas R. (1995)
    2. Hem-1, a potential membrane protein, with expression restricted to blood cells. (PubMed id 1932118)1, 3 Hromas R....Kaushansky K. (1991)
    3. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. (PubMed id 16417406)1, 9 Weiner O.D....Kirschner M.W. (2006)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (PubMed id 17875758)1 Joshi A.D....Joshi S.S. (2007)
    10. An actin-based wave generator organizes cell motility. (PubMed id 17696648)1 Weiner O.D....Kirschner M.W. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3071 HGNC: 4862 AceView: HEM1 Ensembl:ENSG00000123338 euGenes: HUgn3071
    ECgene: NCKAP1L Kegg: 3071 H-InvDB: NCKAP1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCKAP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCKAP1L gene:
    Search GeneIP for patents involving NCKAP1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NCKAP1L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCKAP1L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCKAP1L  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NCKAP1L   OriGene 3'-UTR Clone for NCKAP1L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCKAP1L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NCKAP1L   OriGene Custom Protein Services for NCKAP1L  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCKAP1L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCKAP1L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCKAP1L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCKAP1L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCKAP1L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCKAP1L
     GenScript Custom Purified and Recombinant Proteins Services for NCKAP1L GenScript cDNA clones with any tag delivered in your preferred vector for NCKAP1L
     GenScript Custom Assay Services for NCKAP1L GenScript Custom Superior Antibodies Services for NCKAP1L
     GenScript Custom overexpressing Cell Line Services for NCKAP1L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NCKAP1L promoter
     Search Chromatin IP Primers for NCKAP1L
     RT2 qPCR Primer Assay in human, mouse, rat NCKAP1L
     Search GNC Networks for NCKAP1L
     SABiosciences Custom PCR Arrays for NCKAP1L
     Search Tocris compounds for NCKAP1L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NCKAP1L antibodies
     Search for Antibodies for NCKAP1L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NCKAP1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NCKAP1L Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NCKAP1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCKAP1L
     SwitchGear 3'UTR luciferase reporter plasmids for NCKAP1L
     SwitchGear Promoter luciferase reporter plasmids for NCKAP1L
     Search ThermoFisher Antibodies for NCKAP1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCKAP1L
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NCKAP1L gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4