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Aliases for NCKAP1 Gene

Aliases for NCKAP1 Gene

  • NCK-Associated Protein 1 2 3
  • NAP1 3 4 6
  • Membrane-Associated Protein HEM-2 3 4
  • P125Nap1 3 4
  • HEM2 3 4
  • KIAA0587 4
  • NAP125 3
  • NAP 1 4

External Ids for NCKAP1 Gene

Summaries for NCKAP1 Gene

GeneCards Summary for NCKAP1 Gene

NCKAP1 (NCK-Associated Protein 1) is a Protein Coding gene. Diseases associated with NCKAP1 include nance-horan syndrome. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. An important paralog of this gene is NCKAP1L.

UniProtKB/Swiss-Prot for NCKAP1 Gene

  • Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1

Gene Wiki entry for NCKAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCKAP1 Gene

Genomics for NCKAP1 Gene

Genomic Location for NCKAP1 Gene

Start:
182,909,115 bp from pter
End:
183,038,858 bp from pter
Size:
129,744 bases
Orientation:
Minus strand

Genomic View for NCKAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCKAP1 Gene

Regulatory Elements for NCKAP1 Gene

Proteins for NCKAP1 Gene

  • Protein details for NCKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2A7-NCKP1_HUMAN
    Recommended name:
    Nck-associated protein 1
    Protein Accession:
    Q9Y2A7
    Secondary Accessions:
    • O60329
    • Q53QN5
    • Q53S94
    • Q53Y35

    Protein attributes for NCKAP1 Gene

    Size:
    1128 amino acids
    Molecular mass:
    128790 Da
    Quaternary structure:
    • Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Associates preferentially with the first SH3 domain of NCK. Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with human cytomegalovirus protein UL135.
    SequenceCaution:
    • Sequence=BAA25513.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCKAP1 Gene

    Alternative splice isoforms for NCKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCKAP1 Gene

Proteomics data for NCKAP1 Gene at MOPED

Post-translational modifications for NCKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16, Lys58, and Lys895

Other Protein References for NCKAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NCKAP1 Gene

Domains for NCKAP1 Gene

Protein Domains for NCKAP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NCKP1_HUMAN
Family:
  • Belongs to the HEM-1/HEM-2 family.:
    • Q9Y2A7
genes like me logo Genes that share domains with NCKAP1: view

No data available for Gene Families for NCKAP1 Gene

Function for NCKAP1 Gene

Molecular function for NCKAP1 Gene

UniProtKB/Swiss-Prot Function: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1

Gene Ontology (GO) - Molecular Function for NCKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11418237
GO:0032403 protein complex binding IDA 18560548
GO:0048365 contributes_to Rac GTPase binding IDA 21107423
genes like me logo Genes that share ontologies with NCKAP1: view
genes like me logo Genes that share phenotypes with NCKAP1: view

miRNA for NCKAP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCKAP1 Gene

Localization for NCKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCKAP1 Gene

Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCKAP1 Gene COMPARTMENTS Subcellular localization image for NCKAP1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane --
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane IEA --
GO:0030027 lamellipodium --
genes like me logo Genes that share ontologies with NCKAP1: view

Pathways for NCKAP1 Gene

genes like me logo Genes that share pathways with NCKAP1: view

Pathways by source for NCKAP1 Gene

Gene Ontology (GO) - Biological Process for NCKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0006915 apoptotic process TAS 10673335
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with NCKAP1: view

Transcripts for NCKAP1 Gene

Unigene Clusters for NCKAP1 Gene

NCK-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCKAP1 Gene

No ASD Table

Relevant External Links for NCKAP1 Gene

GeneLoc Exon Structure for
NCKAP1
ECgene alternative splicing isoforms for
NCKAP1

Expression for NCKAP1 Gene

mRNA expression in normal human tissues for NCKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCKAP1 Gene

SOURCE GeneReport for Unigene cluster for NCKAP1 Gene Hs.603732

mRNA Expression by UniProt/SwissProt for NCKAP1 Gene

Q9Y2A7-NCKP1_HUMAN
Tissue specificity: Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle
genes like me logo Genes that share expressions with NCKAP1: view

Orthologs for NCKAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCKAP1 36
  • 99.71 (n)
  • 100 (a)
NCKAP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101907541 36
  • 95.25 (n)
  • 99.55 (a)
NCKAP1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCKAP1 36
  • 94.91 (n)
  • 99.64 (a)
NCKAP1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nckap1 36
  • 91.28 (n)
  • 99.38 (a)
Nckap1 16
Nckap1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCKAP1 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCKAP1 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nckap1 36
  • 90.96 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves NCKAP1 36
  • 87.1 (n)
  • 99.29 (a)
NCKAP1 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCKAP1 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23848 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nckap1 36
  • 83.39 (n)
  • 97.88 (a)
Str.10906 36
zebrafish
(Danio rerio)
Actinopterygii nckap1 36
  • 77.79 (n)
  • 96.26 (a)
nckap1 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004946 36
  • 56.96 (n)
  • 61.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hem 36
  • 58.39 (n)
  • 60.43 (a)
Hem 37
  • 60 (a)
OneToMany
Hem 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea gex-3 36
  • 50.59 (n)
  • 42.31 (a)
gex-3 37
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GRL 36
  • 39.53 (n)
  • 25.49 (a)
rice
(Oryza sativa)
Liliopsida Os08g0544500 36
  • 41.04 (n)
  • 25.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9782 37
  • 59 (a)
OneToMany
Species with no ortholog for NCKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCKAP1 Gene

ENSEMBL:
Gene Tree for NCKAP1 (if available)
TreeFam:
Gene Tree for NCKAP1 (if available)

Paralogs for NCKAP1 Gene

Paralogs for NCKAP1 Gene

Selected SIMAP similar genes for NCKAP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NCKAP1 Gene

genes like me logo Genes that share paralogs with NCKAP1: view

Variants for NCKAP1 Gene

Sequence variations from dbSNP and Humsavar for NCKAP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7510 -- 182,924,921(-) TACCT(G/T)CCATA utr-variant-3-prime
rs908437 -- 183,023,250(+) CTGAA(C/T)ATGAC intron-variant
rs959675 -- 182,968,690(-) tattt(C/T)tgcta intron-variant
rs963107 -- 183,004,354(-) CCTAA(C/T)GTTCC intron-variant
rs963108 -- 183,004,190(-) TTAAA(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCKAP1 Gene

Variant ID Type Subtype PubMed ID
dgv1276e1 CNV Complex 17122850
nsv818096 CNV Gain 17921354
nsv875485 CNV Gain 21882294
esv8239 CNV Gain 19470904

Relevant External Links for NCKAP1 Gene

HapMap Linkage Disequilibrium report
NCKAP1
Human Gene Mutation Database (HGMD)
NCKAP1

Disorders for NCKAP1 Gene

(1) MalaCards Diseases for NCKAP1 Gene

Search for NCKAP1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for NCKAP1 Gene

Disease -log(P) Hits PubMed IDs
scar 58.5 3
alzheimers disease 22.3 3
genes like me logo Genes that share disorders with NCKAP1: view

No data available for UniProtKB/Swiss-Prot for NCKAP1 Gene

Publications for NCKAP1 Gene

  1. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease. (PMID: 10673335) Suzuki T. … Sakaki Y. (Genomics 2000) 2 3 4 23
  2. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K. … Takenawa T. (Biochem. Biophys. Res. Commun. 1997) 2 3
  3. Isolation of hNap1BP which interacts with human Nap 1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. (PMID: 11418237) Yamamoto A. … Sakaki Y. (Gene 2001) 3 23
  4. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. (PMID: 15048123) Innocenti M. … Scita G. (Nat. Cell Biol. 2004) 3 23
  5. Structure and control of the actin regulatory WAVE complex. (PMID: 21107423) Chen Z. … Rosen M.K. (Nature 2010) 3 4

Products for NCKAP1 Gene

Sources for NCKAP1 Gene

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