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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCKAP1 Gene

protein-coding   GIFtS: 60
GCID: GC02M183789

NCK-associated protein 1

 Explore 5 diseases affiliated with
NCKAP1 via our new
 Human Malady Compendium 
Biological research products
for NCKAP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NCK-Associated Protein 11 2     NAP 12 3
HEM21 2 3     P125Nap11
NAP12 3 5     Nap11
NAP1251 2     KIAA05873
Membrane-Associated Protein HEM-22 3     

External Ids:    HGNC: 76661   Entrez Gene: 107872   Ensembl: ENSG000000616767   OMIM: 6048915   UniProtKB: Q9Y2A73   

Export aliases for NCKAP1 gene to outside databases

Previous GC identifers: GC02M181996 GC02M182472 GC02M183753 GC02M183992 GC02M183615 GC02M183497 GC02M175648


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NCKP1_HUMAN, Q9Y2A7
Function: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament
reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1

Gene Wiki entry for NCKAP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCKAP1 gene promoter:
         STAT1   LHX3b/Lhx3b   FOXF2   AML1a   STAT1alpha   GATA-2   AREB6   S8   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): NCKAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCKAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCKAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32

NCKAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCKAP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M183789:  view genomic region     (about GC identifiers)

Start:
183,789,605 bp from pter      End:
183,903,586 bp from pter
Size:
113,982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCKP1_HUMAN, Q9Y2A7 (See protein sequence)
Recommended Name: Nck-associated protein 1  
Size: 1128 amino acids; 128790 Da
Subunit: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the
complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1.
Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated
RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.
Associates preferentially with the first SH3 domain of NCK. Interacts with NYAP1, NYAP2 and MYO16 (By similarity)
Subcellular location: Cell membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Cell projection,
lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=At the interface between
the lamellipodial actin meshwork and the membrane (By similarity)
Sequence caution: Sequence=BAA25513.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for NCKAP1:
3P8C (3D)    
Secondary accessions: O60329 Q53QN5 Q53S94 Q53Y35
Alternative splicing: 2 isoforms:  Q9Y2A7-1   Q9Y2A7-2   

Explore the universe of human proteins at neXtProt for NCKAP1: NX_Q9Y2A7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2A7

  • NCKAP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_038464.1  NP_995314.1  

    ENSEMBL proteins: 
     ENSP00000355348   ENSP00000354251  
    Reactome Protein details: Q9Y2A7
    Human Recombinant Protein Products: 
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    Uscn Proteins for NCKAP1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0030027lamellipodium ----
    GO:0031258lamellipodium membrane IEA--


    NCKAP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NCKAP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019137 Nck-associated_protein-1

    Graphical View of Domain Structure for InterPro Entry Q9Y2A7

    ProtoNet protein and cluster: Q9Y2A7

    UniProtKB/Swiss-Prot: NCKP1_HUMAN, Q9Y2A7
    Similarity: Belongs to the HEM-1/HEM-2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NCKP1_HUMAN, Q9Y2A7
    Function: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament
    reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15296760


    NCKAP1 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for NCKAP1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Synthetic lethal with Ras 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nckap1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  mortality/aging 
     nervous system 

    NCKAP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of actin dynamics for phagocytic cup formation
    Regulation of actin dynamics for phagocytic cup formation1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    Role of myosins in phagosome formation0.80
    Branching and elongation of mother and daughter filaments0.29
    2G-protein signaling_RAC1 in cellular process
    G-protein signaling RAC1 in cellular process1.00
    RAC1 signaling pathway0.34
    G-protein signaling_RAC1 in cellular process1.00
    3Immune System
    Immune System1.00
    Innate Immune System0.46
    4Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton1.00
    Regulation of actin cytoskeleton0.58
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NCKAP1
        G-protein signaling RAC1 in cellular process

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NCKAP1
        Rac1 Pathway

    1 GeneGo (Thomson Reuters) Pathway for NCKAP1
        G-protein signaling RAC1 in cellular process

    5/6 BioSystems Pathways for NCKAP1 (see all 6
        Diurnally regulated genes with circadian orthologs
    Regulation of Actin Cytoskeleton
    Stabilization and expansion of the E-cadherin adherens junction
    ErbB1 downstream signaling
    E-cadherin signaling in the nascent adherens junction

    5/6        Reactome Pathways for NCKAP1 (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System


    1         Kegg Pathway  (Kegg details for NCKAP1):
        Regulation of actin cytoskeleton


    NCKAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCKAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for NCKAP1 (Q9Y2A71, 2, 3 ENSP000003542514) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-389845,EBI-375446 MINT-45990 MINT-45997 MINT-45983 I2D: score=6 STRING: ENSP00000365312
    YWHABP319462, 3, ENSP000003001614MINT-50942 I2D: score=4 STRING: ENSP00000300161
    GAS7O608612, 3, ENSP000003226084MINT-72920 I2D: score=3 STRING: ENSP00000322608
    WASF2Q9Y6W52, 3, ENSP000003962114MINT-45986 I2D: score=2 STRING: ENSP00000396211
    CYFIP1Q7L5761, 2, 3, ENSP000003245494EBI-389845,EBI-1048143 MINT-8307391 I2D: score=2 STRING: ENSP00000324549
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001843neural tube closure IEA--
    GO:0006915apoptotic process TAS10673335
    GO:0007354zygotic determination of anterior/posterior axis, embryo IEA--


    NCKAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NCKAP1
    Search CenterWatch for drugs/clinical trials and news about NCKAP1 / NCKP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCKAP1 gene (2 alternative transcripts): 
    NM_013436.3  NM_205842.1  

    Unigene Cluster for NCKAP1:

    NCK-associated protein 1
    Hs.603732  [show with all ESTs]
    Unigene Representative Sequence: AB011159
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361354 ENST00000360982(uc002upb.3 uc002upc.3) ENST00000477988
    ENST00000478449 ENST00000471640 ENST00000492058 ENST00000493359 ENST00000495619


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    Additional cDNA sequence: 

    AB011159.1 AB014509.1 AK001291.1 AK292914.1 BC015025.1 BT007033.1 

    18 DOTS entries:

    DT.100824866  DT.100824859  DT.87017197  DT.75170947  DT.120967117  DT.97859535  DT.120967122  DT.95161100 
    DT.99936368  DT.100658132  DT.100824857  DT.120967161  DT.91654745  DT.100824858  DT.120967073  DT.91764130 
    DT.91764146  DT.95087700 

    24/452 AceView cDNA sequences (see all 452):

    AW168131 CD677559 CA773895 AU127635 AI811671 BE674464 AA580371 AA862525 
    AW875910 AU133066 BQ962637 CD723488 BC015025 AB011159 AU130812 BE891010 
    AU131998 BM833719 AL119168 AA307472 AL134955 BM828104 AB014509 CB051462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCKAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCCTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NCKAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCKAP1

    SOURCE GeneReport for Unigene cluster: Hs.603732

    UniProtKB/Swiss-Prot: NCKP1_HUMAN, Q9Y2A7
    Tissue specificity: Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in
    brain, heart, and skeletal muscle

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCKAP1 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NCKAP11 NCK-associated protein 1 87.1(n)
    99.29(a)
      424000  XM_001232274.2  XP_001232275.2 
    lizard
    (Anolis carolinensis)
    Reptilia NCKAP16
    --
    99(a)
    1 ↔ 1
    GL343221.1(1907457-1973458)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238482 Xenopus laevis transcribed sequence with moderate similarity more 81.55(n)    CA788519.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570547662   -- 77.54(n)    57054766 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hem1 , 3 axonogenesis3
    HEM-protein1
    59(a)3
    58.39(n)1
    60.43(a)1
      3 79D43
    404621  NM_079490.31  NP_524214.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gex-31 Protein GEX-3 50.68(n)
    42.4(a)
      178191  NM_069967.4  NP_502368.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GRL1 protein NAP1 38.85(n)
    24.58(a)
      818077  NM_129064.3  NP_181056.2 
    rice
    (Oryza sativa)
    Liliopsida Os08g05445001 hypothetical protein 40.39(n)
    25.07(a)
      4346211  NM_001068941.1  NP_001062406.2 


    ENSEMBL Gene Tree for NCKAP1 (if available)
    TreeFam Gene Tree for NCKAP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCKAP1 gene
    NCKAP1L2  
    1 SIMAP similar gene for NCKAP1 using alignment to 1 protein entry:     NCKP1_HUMAN:
    NCKAP1L

    NCKAP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NCKAP1
    PGOHUM00000241901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1621 NCBI SNPs in NCKAP1 are shown (see all 1621    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926112671,2
    --183789166(+) AAACAC/TTGGGT 2 -- int10--------
    rs1467377761,2
    --183789236(+) TTTTAC/TGTCTT 2 -- int10--------
    rs1498339161,2
    --183789304(+) CTCAA-/TTTTTT 2 -- int10--------
    rs558860591,2
    C,F,--183789488(+) TAGCTG/CACCTG 2 -- int14Minor allele frequency- C:0.30WA CSA 124
    rs75101,2
    C,F,A,H,--183789649(-) TACCTT/GCCATA 2 -- ut3129Minor allele frequency- G:0.37MN NA NS EA CSA WA 3914
    rs1837323181,2
    --183790019(+) AACCAC/TAGGTA 2 -- ut310--------
    rs1441516531,2
    --183790051(+) ATGAAA/GTAATT 2 -- ut310--------
    rs46666011,2
    C,F,H,--183790072(+) TGAATG/ACTATA 2 -- ut3126Minor allele frequency- A:0.06NA NS EA WA CSA 2384
    rs1866674991,2
    --183790219(+) AATAAG/TCTCAG 2 -- ut310--------
    rs1465094601,2
    --183790222(+) AATCTC/TAGTGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NCKAP1 (183789605 - 183903586 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for NCKAP1
         3 CNVs: 78893 9435 3401
         1 Indel: 60341
    Human Gene Mutation Database (HGMD): NCKAP1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NCKAP1 for disorders           About GeneDecksing

    OMIM gene information: 604891    OMIM disorders: --

    5 diseases for NCKAP1:    About MalaCards
    nance-horan syndrome    alzheimer's disease    multiple sclerosis    gout
    neuronitis

    2 Novoseek disease relationships for NCKAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scar 58.5 5 18261908 (1), 15296761 (1), 17894861 (1)
    alzheimers disease 22.3 5 11418237 (2), 10673335 (1)


    Export disorders for NCKAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCKAP1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with NCKAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease. (PubMed id 10673335)1, 2, 3, 9 Suzuki T.... Sakaki Y. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. (PubMed id 12181570)1, 3 Eden S....Kirschner M.W. (2002)
    5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    6. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PubMed id 9344857)1, 3 Matuoka K.... Takenawa T. (1997)
    7. Isolation of hNap1BP which interacts with human Nap 1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. (PubMed id 11418237)1, 9 Yamamoto A.... Sakaki Y. (2001)
    8. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. (PubMed id 15048123)1, 9 Innocenti M....Scita G. (2004)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10787 HGNC: 7666 AceView: NCKAP1 Ensembl:ENSG00000061676 euGenes: HUgn10787
    ECgene: NCKAP1 Kegg: 10787 H-InvDB: NCKAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0587

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCKAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCKAP1 gene:
    Search GeneIP for patents involving NCKAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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