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Aliases for NCK2 Gene

Aliases for NCK2 Gene

  • NCK Adaptor Protein 2 2 3 4
  • Growth Factor Receptor-Bound Protein 4 3 4
  • SH2/SH3 Adaptor Protein NCK-Beta 3 4
  • GRB4 3 4
  • Noncatalytic Region Of Tyrosine Kinase, Beta 3
  • Cytoplasmic Protein NCK2 3
  • NCKbeta 3
  • Nck-2 4

External Ids for NCK2 Gene

Previous GeneCards Identifiers for NCK2 Gene

  • GC02P104297
  • GC02P104885
  • GC02P106037
  • GC02P106054
  • GC02P105926
  • GC02P106361
  • GC02P100201

Summaries for NCK2 Gene

Entrez Gene Summary for NCK2 Gene

  • This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCK2 Gene

NCK2 (NCK Adaptor Protein 2) is a Protein Coding gene. Diseases associated with NCK2 include low tension glaucoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include cytoskeletal adaptor activity and receptor signaling complex scaffold activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for NCK2 Gene

  • Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Wiki entry for NCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCK2 Gene

Genomics for NCK2 Gene

Regulatory Elements for NCK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCK2 Gene

105,744,897 bp from pter
105,894,274 bp from pter
149,378 bases
Plus strand

Genomic View for NCK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCK2 Gene

Proteins for NCK2 Gene

  • Protein details for NCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoplasmic protein NCK2
    Protein Accession:
    Secondary Accessions:
    • D3DVK1
    • Q9BWN9
    • Q9UIC3

    Protein attributes for NCK2 Gene

    380 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.

    Three dimensional structures from OCA and Proteopedia for NCK2 Gene

neXtProt entry for NCK2 Gene

Proteomics data for NCK2 Gene at MOPED

Post-translational modifications for NCK2 Gene

Other Protein References for NCK2 Gene

No data available for DME Specific Peptides for NCK2 Gene

Domains for NCK2 Gene

Gene Families for NCK2 Gene

  • SH2D :SH2 domain containing

Protein Domains for NCK2 Gene

Suggested Antigen Peptide Sequences for NCK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43639
  • Contains 1 SH2 domain.
  • Contains 3 SH3 domains.
genes like me logo Genes that share domains with NCK2: view

Function for NCK2 Gene

Molecular function for NCK2 Gene

GENATLAS Biochemistry: transduction adaptator protein 2 interacting with EGFR and PDGFR
UniProtKB/Swiss-Prot Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Ontology (GO) - Molecular Function for NCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity NAS 16835242
GO:0005515 protein binding IPI 10026169
GO:0008093 cytoskeletal adaptor activity NAS 12110186
GO:0030159 receptor signaling complex scaffold activity NAS 12110186
genes like me logo Genes that share ontologies with NCK2: view
genes like me logo Genes that share phenotypes with NCK2: view

Animal Models for NCK2 Gene

MGI Knock Outs for NCK2:

Animal Model Products

CRISPR Products

miRNA for NCK2 Gene

miRTarBase miRNAs that target NCK2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NCK2 Gene

Localization for NCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCK2 Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for NCK2 Gene COMPARTMENTS Subcellular localization image for NCK2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 12110186
GO:0005783 endoplasmic reticulum IDA 16835242
GO:0005829 cytosol TAS --
GO:0012506 vesicle membrane IEA --
genes like me logo Genes that share ontologies with NCK2: view

Pathways for NCK2 Gene

genes like me logo Genes that share pathways with NCK2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007015 actin filament organization IEA --
GO:0007165 signal transduction TAS 9737977
GO:0007172 signal complex assembly NAS 12110186
GO:0007173 epidermal growth factor receptor signaling pathway TAS 9737977
genes like me logo Genes that share ontologies with NCK2: view

Compounds for NCK2 Gene

(1) Novoseek inferred chemical compound relationships for NCK2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 33.8 2
genes like me logo Genes that share compounds with NCK2: view

Transcripts for NCK2 Gene

Unigene Clusters for NCK2 Gene

NCK adaptor protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCK2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for NCK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCK2 Gene

mRNA expression in normal human tissues for NCK2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCK2 Gene

SOURCE GeneReport for Unigene cluster for NCK2 Gene Hs.529244

mRNA Expression by UniProt/SwissProt for NCK2 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NCK2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NCK2 Gene

Orthologs for NCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCK2 35
  • 99.65 (n)
  • 100 (a)
NCK2 36
  • 100 (a)
(Bos Taurus)
Mammalia NCK2 35
  • 85.2 (n)
  • 90.43 (a)
NCK2 36
  • 90 (a)
(Canis familiaris)
Mammalia NCK2 35
  • 91.49 (n)
  • 97.63 (a)
NCK2 36
  • 98 (a)
(Mus musculus)
Mammalia Nck2 35
  • 88.6 (n)
  • 96.05 (a)
Nck2 16
Nck2 36
  • 96 (a)
(Monodelphis domestica)
Mammalia NCK2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia NCK2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Nck2 35
  • 88.68 (n)
  • 95.79 (a)
(Gallus gallus)
Aves NCK2 35
  • 78.33 (n)
  • 92.89 (a)
NCK2 36
  • 93 (a)
(Anolis carolinensis)
Reptilia NCK2 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nck2 35
  • 71.32 (n)
  • 84.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13508 35
(Danio rerio)
Actinopterygii -- 35
nck2a 36
  • 77 (a)
nck2b 35
  • 74.36 (n)
  • 82.76 (a)
nck2b 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta dock 36
  • 32 (a)
dock 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea nck-1 35
  • 51.06 (n)
  • 47.93 (a)
nck-1 36
  • 43 (a)
ZK470.5b 37
  • 42 (a)
ZK470.5a 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for NCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCK2 Gene

Gene Tree for NCK2 (if available)
Gene Tree for NCK2 (if available)

Paralogs for NCK2 Gene

Paralogs for NCK2 Gene

genes like me logo Genes that share paralogs with NCK2: view

Variants for NCK2 Gene

Sequence variations from dbSNP and Humsavar for NCK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15139 -- 105,894,119(-) AAAAT(G/T)CAATT utr-variant-3-prime
rs714068 -- 105,791,468(+) CCCGT(C/T)GCCGT intron-variant
rs714355 -- 105,791,252(+) TCATC(C/T)AGAGA intron-variant
rs717730 -- 105,750,900(-) AGATG(A/G)CAGGC intron-variant
rs746436 -- 105,789,999(+) CTAGC(C/G/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCK2 Gene

Variant ID Type Subtype PubMed ID
nsv834321 CNV Loss 17160897
nsv482913 CNV Gain 15286789
esv994957 OTHER Inversion 20482838
esv22511 CNV Gain 19812545
nsv10108 CNV Loss 18304495
esv2668709 CNV Deletion 23128226
esv2676187 CNV Deletion 23128226
esv24019 CNV Loss 19812545
esv2478624 CNV Insertion 19546169
esv273223 CNV Insertion 20981092
esv270355 CNV Insertion 20981092
esv26794 CNV Gain 19812545

Relevant External Links for NCK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCK2 Gene

Disorders for NCK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NCK2 Gene including...

Search for NCK2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for NCK2 Gene

Relevant External Links for NCK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NCK2: view

No data available for UniProtKB/Swiss-Prot for NCK2 Gene

Publications for NCK2 Gene

  1. Identification of Grb4/Nckbeta, a src homology 2 and 3 domain- containing adapter protein having similar binding and biological properties to Nck. (PMID: 10026169) Braverman L.E. … Quilliam L.A. (J. Biol. Chem. 1999) 3 4 23
  2. Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. (PMID: 9737977) Chen M. … Li W. (J. Biol. Chem. 1998) 2 3 4
  3. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. (PMID: 9843575) Tu Y. … Wu C. (Mol. Biol. Cell 1998) 3 4
  4. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. (PMID: 11557983) Cowan C.A. … Henkemeyer M. (Nature 2001) 3 23
  5. Nck-2 interacts with focal adhesion kinase and modulates cell motility. (PMID: 11950595) Goicoechea S.M. … Wu C. (Int. J. Biochem. Cell Biol. 2002) 3 23

Products for NCK2 Gene

Sources for NCK2 Gene

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