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Aliases for NCK2 Gene

Aliases for NCK2 Gene

  • NCK Adaptor Protein 2 2 3 4 5
  • Growth Factor Receptor-Bound Protein 4 3 4
  • SH2/SH3 Adaptor Protein NCK-Beta 3 4
  • GRB4 3 4
  • Noncatalytic Region Of Tyrosine Kinase, Beta 3
  • NCKbeta 3
  • Nck-2 4

External Ids for NCK2 Gene

Previous GeneCards Identifiers for NCK2 Gene

  • GC02P104297
  • GC02P104885
  • GC02P106037
  • GC02P106054
  • GC02P105926
  • GC02P106361
  • GC02P100201

Summaries for NCK2 Gene

Entrez Gene Summary for NCK2 Gene

  • This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCK2 Gene

NCK2 (NCK Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include SH3/SH2 adaptor activity and cytoskeletal adaptor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for NCK2 Gene

  • Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Wiki entry for NCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCK2 Gene

Genomics for NCK2 Gene

Regulatory Elements for NCK2 Gene

Promoters for NCK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCK2 Gene

Chromosome:
2
Start:
105,744,897 bp from pter
End:
105,894,274 bp from pter
Size:
149,378 bases
Orientation:
Plus strand

Genomic View for NCK2 Gene

Genes around NCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCK2 Gene

Proteins for NCK2 Gene

  • Protein details for NCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43639-NCK2_HUMAN
    Recommended name:
    Cytoplasmic protein NCK2
    Protein Accession:
    O43639
    Secondary Accessions:
    • D3DVK1
    • Q9BWN9
    • Q9UIC3

    Protein attributes for NCK2 Gene

    Size:
    380 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.

    Three dimensional structures from OCA and Proteopedia for NCK2 Gene

neXtProt entry for NCK2 Gene

Proteomics data for NCK2 Gene at MOPED

Post-translational modifications for NCK2 Gene

Antibody Products

No data available for DME Specific Peptides for NCK2 Gene

Domains & Families for NCK2 Gene

Gene Families for NCK2 Gene

Protein Domains for NCK2 Gene

Suggested Antigen Peptide Sequences for NCK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43639

UniProtKB/Swiss-Prot:

NCK2_HUMAN :
  • Contains 1 SH2 domain.
Domain:
  • Contains 1 SH2 domain.
  • Contains 3 SH3 domains.
genes like me logo Genes that share domains with NCK2: view

Function for NCK2 Gene

Molecular function for NCK2 Gene

GENATLAS Biochemistry:
transduction adaptator protein 2 interacting with EGFR and PDGFR
UniProtKB/Swiss-Prot Function:
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Ontology (GO) - Molecular Function for NCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030159 receptor signaling complex scaffold activity NAS 12110186
genes like me logo Genes that share ontologies with NCK2: view
genes like me logo Genes that share phenotypes with NCK2: view

Animal Models for NCK2 Gene

MGI Knock Outs for NCK2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCK2 Gene

Localization for NCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCK2 Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCK2 Gene COMPARTMENTS Subcellular localization image for NCK2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
golgi apparatus 3
cytoskeleton 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NCK2 Gene

Pathways & Interactions for NCK2 Gene

genes like me logo Genes that share pathways with NCK2: view

SIGNOR curated interactions for NCK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 immunological synapse formation IEA --
GO:0007165 signal transduction TAS 9737977
GO:0007172 signal complex assembly NAS 12110186
GO:0007173 epidermal growth factor receptor signaling pathway TAS 9737977
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with NCK2: view

Drugs & Compounds for NCK2 Gene

(1) Drugs for NCK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NCK2: view

Transcripts for NCK2 Gene

Unigene Clusters for NCK2 Gene

NCK adaptor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for NCK2 Gene

GeneLoc Exon Structure for
NCK2
ECgene alternative splicing isoforms for
NCK2

Expression for NCK2 Gene

mRNA expression in normal human tissues for NCK2 Gene

Protein differential expression in normal tissues from HIPED for NCK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCK2 Gene



SOURCE GeneReport for Unigene cluster for NCK2 Gene Hs.529244

mRNA Expression by UniProt/SwissProt for NCK2 Gene

O43639-NCK2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NCK2: view

Protein tissue co-expression partners for NCK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NCK2 Gene

Orthologs for NCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCK2 35
  • 85.2 (n)
  • 90.43 (a)
NCK2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCK2 35
  • 91.49 (n)
  • 97.63 (a)
NCK2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nck2 35
  • 88.6 (n)
  • 96.05 (a)
Nck2 16
Nck2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCK2 35
  • 99.65 (n)
  • 100 (a)
NCK2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nck2 35
  • 88.68 (n)
  • 95.79 (a)
oppossum
(Monodelphis domestica)
Mammalia NCK2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCK2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCK2 35
  • 78.33 (n)
  • 92.89 (a)
NCK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCK2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nck2 35
  • 71.32 (n)
  • 84.21 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
nck2b 35
  • 74.36 (n)
  • 82.76 (a)
nck2a 36
  • 77 (a)
OneToMany
nck2b 36
  • 82 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13508 35
fruit fly
(Drosophila melanogaster)
Insecta dock 37
  • 42 (a)
dock 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK470.5a 37
  • 41 (a)
ZK470.5b 37
  • 42 (a)
nck-1 35
  • 51.06 (n)
  • 47.93 (a)
nck-1 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for NCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCK2 Gene

ENSEMBL:
Gene Tree for NCK2 (if available)
TreeFam:
Gene Tree for NCK2 (if available)

Paralogs for NCK2 Gene

Paralogs for NCK2 Gene

genes like me logo Genes that share paralogs with NCK2: view

Variants for NCK2 Gene

Sequence variations from dbSNP and Humsavar for NCK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15139 -- 105,894,119(-) AAAAT(G/T)CAATT utr-variant-3-prime
rs717730 -- 105,750,900(-) AGATG(A/G)CAGGC intron-variant
rs768003 -- 105,868,384(+) CATAA(G/T)TTAAA intron-variant
rs746436 -- 105,789,999(+) CTAGC(C/G/T)TGTTC intron-variant
rs746437 -- 105,790,216(-) TGCAC(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCK2 Gene

Variant ID Type Subtype PubMed ID
nsv834321 CNV Loss 17160897
nsv482913 CNV Gain 15286789
esv994957 OTHER Inversion 20482838
esv22511 CNV Gain 19812545
nsv10108 CNV Loss 18304495
esv2668709 CNV Deletion 23128226
esv2676187 CNV Deletion 23128226
esv24019 CNV Loss 19812545
esv2478624 CNV Insertion 19546169
esv273223 CNV Insertion 20981092
esv270355 CNV Insertion 20981092
esv26794 CNV Gain 19812545

Variation tolerance for NCK2 Gene

Residual Variation Intolerance Score: 9.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCK2 Gene

HapMap Linkage Disequilibrium report
NCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCK2 Gene

Disorders for NCK2 Gene

Relevant External Links for NCK2

Genetic Association Database (GAD)
NCK2
Human Genome Epidemiology (HuGE) Navigator
NCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCK2

No disorders were found for NCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCK2 Gene

Publications for NCK2 Gene

  1. Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. (PMID: 9737977) Chen M. … Li W. (J. Biol. Chem. 1998) 2 3 4 67
  2. Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. (PMID: 16752908) Liu J. … Song J. (Biochemistry 2006) 2 3
  3. Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. (PMID: 12794636) Velyvis A. … Qin J. (Nat. Struct. Biol. 2003) 3 23
  4. Nck-2 interacts with focal adhesion kinase and modulates cell motility. (PMID: 11950595) Goicoechea S.M. … Wu C. (Int. J. Biochem. Cell Biol. 2002) 3 23
  5. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. (PMID: 11557983) Cowan C.A. … Henkemeyer M. (Nature 2001) 3 23

Products for NCK2 Gene

Sources for NCK2 Gene

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