NCK1 Gene
protein-coding GIFtS: 65
GCID: GC03P136581
|
|
NCK adaptor protein 1
(Previous symbol: NCK)
| |
Aliases
for NCK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NCK Adaptor Protein 11 2 3 | | Melanoma NCK Protein2 | | NCK1 2 3 5 | | NCK Tyrosine Kinase2 | | NCKalpha1 2 | | Nck-13 | | SH2/SH3 Adaptor Protein NCK-Alpha2 3 | | Non-Catalytic Region Of Tyrosine Kinase2 | | Cytoplasmic Protein NCK12 | | Nck-13 |
Export aliases for NCK1 gene to outside databasesPrevious GC identifers: GC03P133543 GC03P137332 GC03P137862 GC03P137901 GC03P138063 GC03P133957 |
Summaries
for NCK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCK1:
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals fromreceptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variantsencoding different isoforms have been found. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR andPDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting itsdephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, butfor efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependenttranscriptional activation in response to activated Ras signaling
Gene Wiki entry for NCK1
|
Genomic Views
for NCK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCK1 gene promoter:
HFH-3 AML1a AP-1 ATF-2 FOXD1 C/EBPalpha Evi-1 AREB6 FOXI1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q21NCK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P136581: view genomic region
(about GC identifiers)
Start:
|
136,581,050 bp from pter |
End:
|
136,668,665 bp from pter |
Size:
|
87,616 bases |
Orientation:
|
plus strand |
|
Proteins
for NCK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333 (See
protein sequence)Recommended Name: Cytoplasmic protein NCK1 Size: 377 amino acids; 42864 Da
Subunit: Interacts (via SH2 domain and SH3 domain 2) with EGFR. Interacts with PAK1 and SOS1. Interacts (via SH3domains) with PKN2. Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion.Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 andNCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interactswith FASLG. Directly interacts with RASA1. Interacts with isoform 4 of MINK1. Interacts with FLT1 (tyrosine.phosphorylated). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH2 domain) with EPHB1; activates theJUN cascade to regulate cell adhesion. Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated)
Subcellular location: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between thecytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclearfollowing genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments
6 PDB 3D structures from  and Proteopedia  for NCK1:2CI8 (3D)
2CI9 (3D)
2CUB (3D)
2JS0 (3D)
2JS2 (3D)
2JW4 (3D)
Secondary accessions: B7Z751 D3DNE3Alternative splicing: 2 isoforms: P16333-1 P16333-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NCK1: NX_P16333
Post-translational modifications:
Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated byactivated PDGFRB1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P16333
NCK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001177725.1 NP_006144.1
ENSEMBL proteins: ENSP00000288986 ENSP00000417273 ENSP00000419302 ENSP00000419677 ENSP00000418513 ENSP00000417729 ENSP00000419544 ENSP00000419631 ENSP00000418060 Reactome Protein details: P16333
Human Recombinant Protein Products for NCK1:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
NCK1 for ontologies About GeneDecksing
NCK1 Antibody Products:
Assay Products for NCK1: |
Protein
Domains /
Families
for NCK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCK1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P16333ProtoNet protein and cluster: P16333 2 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333Domain: Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2domains do not seeem to be involvedSimilarity: Contains 1 SH2 domainSimilarity: Contains 3 SH3 domains |
Function
for NCK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCK1_HUMAN, P16333Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR andPDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting itsdephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, butfor efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependenttranscriptional activation in response to activated Ras signaling Genatlas biochemistry entry for NCK1:transduction adaptor protein 1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NCK1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for NCK1:
9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nck1):
NCK1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCK1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NCK1 (NM_006153) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCK1 |
|
Pathways & Interactions
for NCK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/45 super-pathways (see all 45) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development EGFR signaling pathway | | | 2 | Regulation of actin dynamics for phagocytic cup formation | | | 3 | Development_PDGF signaling via STATs and NF-kB | | | 4 | Immune System | | | 5 | Cell adhesion_Ephrins signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for NCK1
5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCK1 (see all 11)
3 
Cell Signaling Technology (CST) Pathways for NCK1
5/6  GeneGo (Thomson Reuters) Pathways for NCK1 (see all 6)
5/19  BioSystems Pathways for NCK1 (see all 19)
5/23 
Reactome Pathways for NCK1 (see all 23)
4 
Kegg Pathways (Kegg details for NCK1):
NCK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/365 Interacting proteins for NCK1 (P163331, 2, 3 ENSP000002889864) via UniProtKB, MINT, STRING, and/or I2D (see all 365)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| LCP2 | Q130942, 3, ENSP000000467944 | MINT-7995411 MINT-7995531 MINT-7995426 MINT-7995458 MINT-8029667 MINT-7995504 MINT-8224277 MINT-7306527 MINT-7995396 MINT-7995442 MINT-8037396 MINT-7995380 MINT-7995488 MINT-7995474 I2D:
score=7 STRING: ENSP00000046794 | | MAP4K1 | Q929181, 2, 3, ENSP000003800664 | EBI-3448658,EBI-881 MINT-7213100 MINT-7213019 I2D:
score=7 STRING: ENSP00000380066 | | ASAP1 | Q9ULH11, 2, 3, ENSP000003502974 | EBI-3448658,EBI-346622 MINT-7145783 I2D:
score=3 STRING: ENSP00000350297 | | CD3E | P077662, 3, ENSP000003545664 | MINT-7233971 MINT-7234008 MINT-7214135 MINT-7213923 MINT-7233987 MINT-7214094 I2D:
score=5 STRING: ENSP00000354566 | | WAS | P427682, 3, ENSP000003658914 | MINT-14451 MINT-14453 MINT-14452 I2D:
score=8 STRING: ENSP00000365891 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
NCK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCK1 for compounds About GeneDecksing
 Browse Tocris compounds for NCK1
10/11 Novoseek chemical compound relationships for NCK1 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
72.2 |
79 |
1448108 (4), 1333047 (3), 10229072 (3), 1280326 (3) (see all 46) |
| phosphotyrosine |
65.1 |
8 |
9362449 (3), 15132304 (2), 8265614 (1) |
| phosphatidylinositol |
40.2 |
7 |
8890167 (1), 7692230 (1), 9837978 (1), 10523848 (1) (see all 7) |
| serine |
38.2 |
13 |
1333047 (3), 1448108 (3), 9135144 (1), 1280326 (1) (see all 7) |
| threonine |
36.1 |
8 |
1333047 (2), 9135144 (1), 1280326 (1), 7706279 (1) (see all 5) |
| pip2 |
36.1 |
1 |
12147689 (1) |
| proline |
27.6 |
2 |
10671570 (1) |
| phosphoinositide |
27 |
4 |
8894489 (1), 9531977 (1) |
| vanadate |
19.4 |
2 |
8895336 (2) |
| phenylalanine |
13.4 |
2 |
10202139 (1), 11551902 (1) |
Search CenterWatch for drugs/clinical trials and news about NCK1
|
Transcripts
for NCK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCK1 gene (2 alternative transcripts): NM_001190796.1 NM_006153.4 Unigene Cluster for NCK1: NCK adaptor protein 1 Hs.477693 [show with all ESTs]Unigene Representative Sequence: NM_00615312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000288986(uc003erh.3) ENST00000481752 ENST00000491539 ENST00000485096
ENST00000476286 ENST00000460960 ENST00000478862 ENST00000488930 ENST00000496489
ENST00000469404(uc011bme.2) ENST00000467911 ENST00000482071
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCK1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NCK1 (NM_006153) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCK1 |
Additional cDNA sequence: AK301460.1 AK312692.1 BC006403.2 X17576.1 8 DOTS entries: DT.413499 DT.95265172 DT.91707118 DT.100022098 DT.120842121 DT.91694270 DT.101976672 DT.120842106 24/87 AceView cDNA sequences (see all 87): BM981906 BG402926 BC006403 CB132726 AI360552 BF445782 AU107243 BQ002749 BF032608 NM_006153 AL597174 AA278763 AA746252 AA724030 BM975093 AI754384 AI150310 BG540216 BI598512 AW613764 AW182810 BI007404 AL701783 CB070168
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NCK1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for NCK1
|
Expression
for NCK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTACAATT
About this image
See NCK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCK1
SOURCE GeneReport for Unigene cluster: Hs.477693
SABiosciences Expression via Pathway-Focused PCR Arrays including NCK1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCK1 |
Orthologs
for NCK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NCK1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nck11 , 5 |
non-catalytic region of tyrosine kinase adaptor protein more1, 5 |
92.84(n)1
98.94(a)1 |
|
9 (52.69 cM)5
179731 NM_010878.21 NP_035008.21
1004922935 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.3792 |
Xenopus laevis SH2/SH3 adaptor protein (Nck) mRNA, more |
79.58(n) |
|
U85781.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003349531 |
cytoplasmic protein NCK1-like |
68.79(n)
77.72(a) |
|
100334953 XM_002666595.2 XP_002666641.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dock1 , 3 |
axon guidance SH3/SH2 adaptor protein3
dreadlocks1 |
43(a)3
52.17(n)1
49.72(a)1 |
|
2 21D33
332621 NM_164389.11 NP_722657.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK470.5b3 |
-- |
40(a)
(best of 2) |
|
X(4184350-4185897) -- |
ENSEMBL Gene Tree for NCK1 (if available)
TreeFam Gene Tree for NCK1 (if available) |
Paralogs
for NCK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NCK1 gene
- GRAP2 GRAPL2 NCK22 GRAP22 GRB22
11 SIMAP similar genes for NCK1 using alignment to 7 protein entries: NCK1_HUMAN (see all proteins):NCK2 FYN GRB2 CSK LYN LCK
EPS8L1 PTPN11 TXK GRAPL GRAP2
NCK1 for paralogs About GeneDecksing
|
Genomic Variants
for NCK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCK1 (136581050 - 136668665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NCK1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCK1 |
|
Disorders
/ Diseases
for NCK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCK1 for disorders About GeneDecksing
OMIM gene information: 600508
OMIM disorders: --
15  diseases for NCK1: About MalaCardswiskott-aldrich syndrome melanoma hepatitis b gout
vaccinia alzheimer's disease lung carcinoma immunodeficiency
colorectal cancer prostate cancer breast cancer hepatitis
prostatitis carcinoma neuronitis
4 Novoseek disease relationships for NCK1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: NCK1 (3 documents)
Export disorders for NCK1 gene to outside databases
|
Publications
for NCK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCK1 gene, integrated from 9 sources (see all 243):
(articles sorted by number of sources associating them with NCK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2, 9 Kremer B.E.... Macara I.G. (2007)
- The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. (PubMed id 1448108)1, 2, 9 Meisenhelder J. and Hunter T. (1992)
- Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2). (PubMed id 7806213)1, 3, 9 Huebner K....Cannizzaro L. (1994)
- Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. (PubMed id 10026169)1, 2, 9 Braverman L.E. and Quilliam L.A. (1999)
- A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PubMed id 9344857)1, 2, 9 Matuoka K.... Takenawa T. (1997)
- Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. (PubMed id 9737977)1, 3, 9 Chen M....Li W. (1998)
- Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PubMed id 12091389)1, 2, 9 Lee H....Lisanti M.P. (2002)
- Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. (PubMed id 10747847)1, 2, 9 Rebhun J.F....Quilliam L.A. (2000)
- Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity. (PubMed id 21664272)1, 2 Ger M.... Valius M. (2011)
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
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External Searches for NCK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NCK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NCK1 gene
(According to HUGE)
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Specialized Databases showing NCK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for NCK1 gene:
Search GeneIP for patents involving NCK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NCK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | | | Search Tocris compounds for NCK1 |
| |  |  |  |  | | | | | | Recombinant Protein for NCK1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCK1 |
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