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NCK1 Gene

protein-coding GIFtS: 63

GC03P138063

NCK adaptor protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NCK)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC12668 ^²
NCK ^², ³
NCKalpha ^¹, ²
Nck-1 ^³

Descriptions
NCK adaptor protein 1 ^², ³
NCK tyrosine kinase ^²
SH2/SH3 adaptor protein NCK-alpha ^², ³
melanoma NCK protein ^²
non-catalytic region of tyrosine kinase ^²

External Ids
HGNC: 7664¹
Entrez Gene: 4690²
UniProtKB: P16333³
Ensembl: ENSG00000158092⁷

Search outside databases for aliases for NCK1 gene

Previous GC identifers: GC03P133543 GC03P137332 GC03P137862 GC03P137901

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for NCK1:

The protein encoded by this gene is one of the signaling and transforming proteins containing Src

homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein

involved in transducing signals from receptor tyrosine kinases to downstream signal recipients

such as RAS. [provided by RefSeq]

UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333

Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or

their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its

dephosphorylation by PP1

Gene Wiki entry for NCK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NCK1 gene

Entrez Gene cytogenetic band: 3q21 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q21

NCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P138063: (about GC identifiers)

Start:	138,063,763 bp from pter
End:	138,150,658 bp from pter
Size:	86,896 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333 (See protein sequence)

Recommended Name: Cytoplasmic protein NCK1

Size: 377 amino acids; 42864 Da

Subunit: Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion.

Interacts with SOCS7. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1

Subcellular location: Cytoplasm. Endoplasmic reticulum

PDB structures from and Proteopedia :

2CI8 (3D)

2CI9 (3D)

2CUB (3D)

2JS0 (3D)

2JS2 (3D)

2JW4 (3D)

Post-translational modifications:

Phosphorylated on Ser and Tyr residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006144.1

ENSEMBL proteins:

ENSP00000288986

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nck, Nck 1/2)
	Human Recombinant Proteins from Abnova (NCK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	12110186
GO:0005783	endoplasmic reticulum	IEA	--
GO:0012506	vesicle membrane	IEA	--

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Antibodies for NCK1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NCK1
	Sigma-Aldrich Antibodies for NCK1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NCK1
	Antibodies from Abcam (Nck, Nck 1/2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NCK1)
	Novus Biologicals Antibodies for NCK1

Assays for NCK1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P16333

ProtoNet protein and cluster: P16333

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333

Similarity: Contains 1 SH2 domain

Similarity: Contains 3 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006153

Applied Biosystems Silencer® siRNAs for NCK1

Sigma-Aldrich siRNA for NCK1

Sigma-Aldrich shRNA Panels and shRNA for NCK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NCK1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006153
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006153
untagged cDNA clones in CMV expression vector (see all 2): NM_006153

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006153

UniProtKB/Swiss-Prot: NCK1_HUMAN, P16333

Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or

their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its

dephosphorylation by PP1

Genatlas biochemistry entry for NCK1:

transduction adaptor protein 1

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nck1):

behavior/neurological	cellular	embryogenesis	growth/size	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	nervous system	normal	renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	12110186
GO:0008093	cytoskeletal adaptor activity	NAS	12110186
GO:0019904	protein domain specific binding	IEA	--
GO:0030159	receptor signaling complex scaffold activity	NAS	12110186

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for NCK1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Ephrin Receptor Signaling
Insulin Receptor Signaling
Axonal Guidance Signaling
Angiopoietin Signaling
Natural Killer Cell Signaling

GeneDecks NCK1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NCK1

5/274 Interacting proteins for NCK1 (P16333^{1, 2} ENSP00000288986³) via UniProtKB, MINT, and/or STRING (see all 274 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WAS	P42768², ENSP00000365891³	MINT-14451 MINT-14453 MINT-14452 STRING (score=.999)
CBL	P22681², ENSP00000264033³	MINT-17932 MINT-17931 MINT-17933 STRING (score=.971)
EGFR	P00533², ENSP00000275493³	MINT-74587 MINT-16622 STRING (score=.999)
PAK1	Q13153², ENSP00000278568³	MINT-16498 MINT-61476 STRING (score=.999)
WASL	O00401¹, ENSP00000223023³	EBI-389883, EBI-957615 STRING (score=.999)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006417	regulation of translation	IEA	--
GO:0007015	actin filament organization	IEA	--
GO:0007172	signal complex assembly	NAS	12110186
GO:0016477	cell migration	IEA	--
GO:0030032	lamellipodium assembly	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NCK1
9 Novoseek chemical compound relationships for NCK1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	72.43	79	1448108 (4), 1333047 (3), 10229072 (3), 1280326 (3) (see all 46)
phosphotyrosine	65.67	8	9362449 (3), 15132304 (2), 8265614 (1)
phosphatidylinositol	41.26	7	8890167 (1), 7692230 (1), 9837978 (1), 10523848 (1) (see all 7)
threonine	37.19	8	1333047 (2), 9135144 (1), 1280326 (1), 7706279 (1) (see all 5)
pip2	36.69	1	12147689 (1)
proline	28.84	2	10671570 (1)
phosphoinositide	28.39	4	8894489 (1), 9531977 (1)
vanadate	20.02	2	8895336 (2)
phenylalanine	14.40	2	10202139 (1), 11551902 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NCK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NCK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006153

Sigma-Aldrich siRNA for NCK1

Sigma-Aldrich shRNA Panels and shRNA for NCK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006153

REFSEQ mRNAs for NCK1 gene:

NM_006153.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006153

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006153
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006153
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006153

Additional cDNA sequence:

AK301460.1 AK312692.1 BC006403.2 X17576.1

8 DOTS entries:

DT.413499 DT.95265172 DT.91707118 DT.100022098 DT.120842121 DT.91694270 DT.101976672 DT.120842106

24/87 AceView cDNA sequences (see all 87 ):

BC006403 NM_006153 AA278763 AI754384 AA746252 BF445782 AL597174 BM975093

BF032608 CB132726 AI360552 AA724030 BM981906 BQ002749 AU107243 BG402926

CB070168 BQ428732 BF686176 BF671694 BI598035 D58896 AI935447 CF994948

highest scoring ESTs for NCK1:

X17576 AA151454 AA151455 AA278763 AA278867 AA280548 AA724030 AA746252 AI003628 AI075925

Unigene Cluster for NCK1:

NCK adaptor protein 1

Hs.477693 [show with all ESTs]

Unigene Representative Sequence: NM_006153

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NCK1 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	·	8c	^	9
SP1:							-		-		-		-						-		-
SP2:							-				-		-						-		-
SP3:									-				-						-		-
SP4:									-		-		-						-		-
SP5:																			-		-								-		-

About this scheme

ECgene alternative splicing isoforms for NCK1

1 Ensembl transcript including schematic representation:

ENST00000288986

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NCK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NCK1

¹ / ² / ³

6 probe-sets matching NCK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41795_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.03	X17576	1.00	0.90	0.95	1
989_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.97	X17576	1.00	0.90	0.95	1
211063_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006403	0.80	0.88	0.84	1
204725_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006153	0.60	0.83	0.73	1
211063_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204725_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NCK1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGTACAATT

SOURCE GeneReport for Unigene cluster: Hs.477693
Expression variation in blood from EXPOLDB for NCK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NCK1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NCK1¹	--	NCK adaptor protein 1	95.84(n) 99.2(a)	485677 XM_846945.1 XP_852038.1
chimpanzee (Pan troglodytes)	NCK1¹	--	NCK adaptor protein 1	99.82(n) 100(a)	460720 XM_001154556.1 XP_001154556.1
cow (Bos taurus)	NCK1¹	--	NCK adaptor protein 1	95.31(n) 98.94(a)	536154 NM_001076072.1 NP_001069540.1
rat (Rattus norvegicus)	Nck1¹	--	NCK adaptor protein 1	91.94(n) 98.04(a)	300955 XM_217246.3 XP_217246.3
mouse (Mus musculus)	Nck1^{1, 5}	9⁵	non-catalytic region of tyrosine kinase adaptor protein more^{1, 5}	92.84(n)¹ 98.94(a)¹	17973¹ NM_010878.2¹ NP_035008.2¹ AF043259⁵ AF084183⁵ (see all 10)

About this table Species with no ortholog for NCK1

ENSEMBL Gene Tree for NCK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NCK1 gene

GRAP² NCK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/433 NCBI SNPs in NCK1 are shown (see all 433 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6439672^1,2	A,C,F,H	138061889(+)	`TGTTGA/CCCAGT`	1	--	ng5¹		4	EU EA WA	418
	rs1048145^1,2	C,F,H	138150095(+)	`AAATCT/CATATG`	1	--	ut3¹		11	NA EU EA WA	974
	rs9836807^1,2	C,F,H	138063214(+)	`AGGACC/ACTTTT`	1	--	ng5¹		8	EU EA WA NA	724
	rs13320485^1,2	C,F,H	138147427(+)	`ATTAGC/TAGCAG`	1	A/V	mis¹ ese³		8	EU EA WA	836
	rs1385305^1,2	C,F	138150358(+)	`TGTTAT/CGGTTT`	1	--	ut3¹		4	MN NA	324
--	rs11547830^1,2	H	138147355(+)	`GTTCCC/ATTCAA`	1	H/P	mis¹ ese³		4	EU EA WA	404
--	rs11547829^1,2	H	138147399(+)	`GTGACC/AATGTG`	1	N/H	mis¹		4	EU EA WA	406
	rs2031029^1,2	A,C,F,H,O	138082504(+)	`tacccA/Tacatt`	1	--	int¹		12	MN EU EA WA NA	1162
	rs1865149^1,2	A,C,F,H,O	138078300(-)	`TCTCAT/CTGTAG`	1	--	int¹		14	EU EA WA NA	1236
	rs1347209^1,2	A,C,F,H,O	138109387(+)	`CCTCAT/GTGCTA`	1	--	int¹		15	EU EA WA NA	1332

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HapMap Linkage Disequilibrium images for NCK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600508

4 Novoseek disease relationships for NCK1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	82.50	7	9694849 (1), 16990791 (1), 7565724 (1), 11739662 (1) (see all 7)
tumors	3.39	1	8649775 (1)
immunodeficiency	0.00	2	14585966 (1), 11160719 (1)
leukemia	0.00	1	10372803 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/193 PubMed articles for NCK1 gene (see all 193 ):

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. (PubMed id 1448108)^{1, 3, 4} Meisenhelder J. and Hunter T. (1992)
Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2). (PubMed id 7806213)^{1, 2, 3} Huebner K....Cannizzaro L. (1994)
A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PubMed id 9344857)^{1, 3, 4} Matuoka K.... Takenawa T. (1997)
Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. (PubMed id 9737977)^{1, 2, 3} Chen M....Li W. (1998)
Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. (PubMed id 10747847)^{1, 3, 4} Rebhun J.F....Quilliam L.A. (2000)
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. (PubMed id 16835242)^{3, 4} Latreille M. and Larose L. (2006)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
BLNK: a central linker protein in B cell activation. (PubMed id 9697839)^{3, 4} Fu C.... Chan A.C. (1998)
Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP. (PubMed id 1333046)^{3, 4} Park D. and Rhee S.G. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4690	HGNC: 7664	AceView: NCK1	Ensembl:ENSG00000158092	euGenes: HUgn4690
ECgene: NCK1	H-InvDB: NCK1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NCK1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NCK1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NCK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NCK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NCK1		Antibodies for NCK1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NCK1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NCK1)
	Antibodies (NCK1)
	Chimera RNAi (NCK1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NCK1

	Recombinant Proteins (Nck, Nck 1/2)
	Antibodies (Nck, Nck 1/2)

Search OriGene for NCK1

Search Tocris compounds for NCK1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NCK1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NCK1 Gene at Home site.
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NCK1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for NCK1

Summaries
for NCK1

Genomic Location
for NCK1

Proteins
for NCK1

Protein Domains/
Families
for NCK1

Gene Function
for NCK1

Pathways & Interactions
for NCK1

Drugs & Compounds
for NCK1

Transcripts
for NCK1

Expression
for NCK1

Orthologs
for NCK1

Paralogs
for NCK1

SNPs/Variants
for NCK1

Disorders & Mutations
for NCK1

Medical News
for NCK1

Publications
for NCK1

Search for NCK1

Genome Databases showing NCK1

Other Databases showing NCK1

Specialized Databases showing NCK1

Licensable Technologies
for NCK1

Services
for NCK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NCK1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor NCK1

Summariesfor NCK1

Genomic Locationfor NCK1

Proteinsfor NCK1

Protein Domains/Familiesfor NCK1

Gene Functionfor NCK1

Pathways & Interactionsfor NCK1

Drugs & Compoundsfor NCK1

Transcriptsfor NCK1

Expression for NCK1

Orthologsfor NCK1

Paralogsfor NCK1

SNPs/Variantsfor NCK1

Disorders & Mutationsfor NCK1

Medical Newsfor NCK1

Publicationsfor NCK1

Search for NCK1

Genome Databases showing NCK1

Other Databases showing NCK1

Specialized Databases showing NCK1

Licensable Technologiesfor NCK1

Servicesfor NCK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NCK1

Summaries
for NCK1

Genomic Location
for NCK1

Proteins
for NCK1

Protein Domains/
Families
for NCK1

Gene Function
for NCK1

Pathways & Interactions
for NCK1

Drugs & Compounds
for NCK1

Transcripts
for NCK1

Expression
for NCK1

Orthologs
for NCK1

Paralogs
for NCK1

SNPs/Variants
for NCK1

Disorders & Mutations
for NCK1

Medical News
for NCK1

Publications
for NCK1

Licensable Technologies
for NCK1

Services
for NCK1