NCF4 Gene
protein-coding GIFtS: 63
GCID: GC22P037257
|
|
neutrophil cytosolic factor 4, 40kDa(Previous name: neutrophil cytosolic factor 4 (40kD) )
| |
Aliases
for NCF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neutrophil Cytosolic Factor 4, 40kDa1 2 | | SH3 And PX Domain-Containing Protein 42 3 | | SH3PXD41 2 3 | | P40PHOX2 5 | | P40phox1 | | Neutrophil Cytosolic Factor 4 (40kD)1 | | Neutrophil NADPH Oxidase Factor 42 3 | | NCF2 | | NCF-42 3 | | Neutrophil Cytosol Factor 42 | | P40-Phox1 | | |
Export aliases for NCF4 gene to outside databasesPrevious GC identifers: GC22P033871 GC22P035500 GC22P035581 GC22P020219 |
Summaries
for NCF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCF4:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyteNADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed incells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complexwith neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 andtranslocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, themembrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid productsof the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of thisprotein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encodingdistinct isoforms have been observed. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NCF4_HUMAN, Q15080Function: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in whichelectrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may beimportant for the assembly and/or activation of the NADPH-oxidase complex
Gene Wiki entry for NCF4 (Neutrophil cytosolic factor 4)
|
Genomic Views
for NCF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCF4 gene promoter:
Egr-1 NRSF form 1 Lmo2 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1NCF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P037257: view genomic region
(about GC identifiers)
Start:
|
37,257,030 bp from pter |
End:
|
37,274,059 bp from pter |
Size:
|
17,030 bases |
Orientation:
|
plus strand |
|
Proteins
for NCF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCF4_HUMAN, Q15080 (See
protein sequence)Recommended Name: Neutrophil cytosol factor 4 Size: 339 amino acids; 39032 Da
Subunit: p40-PHOX associates primarily with p67-PHOX to form a complex with p47-PHOX
Subcellular location: Cytoplasm
6 PDB 3D structures from  and Proteopedia  for NCF4:1H6H (3D)
1OEY (3D)
1W6X (3D)
1W70 (3D)
1Z9Q (3D)
2DYB (3D)
Secondary accessions: A8K4F9 O60808 Q86U56 Q9BU98 Q9NP45Alternative splicing: 3 isoforms: Q15080-1 Q15080-2 Q15080-3 Explore the universe of human proteins at neXtProt for NCF4: NX_Q15080
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15080
NCF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000622.2 NP_038202.2
ENSEMBL proteins: ENSP00000414958 ENSP00000248899 ENSP00000380334 ENSP00000408619 Reactome Protein details: Q15080
Human Recombinant Protein Products for NCF4:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NCF4 for ontologies About GeneDecksing
NCF4 Antibody Products:
Assay Products for NCF4: |
Protein
Domains /
Families
for NCF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCF4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15080ProtoNet protein and cluster: Q15080 4 Blocks protein families: IPB000270 Octicosapeptide/Phox/Bem1p IPB000919 Neutrophil cytosol factor P40 signature IPB001452 SH3 domain signature IPB001683 Phox-like
UniProtKB/Swiss-Prot: NCF4_HUMAN, Q15080Domain: The OPR/PB1 domain mediates the association with NCF2/p67-PHOXSimilarity: Contains 1 OPR domainSimilarity: Contains 1 PX (phox homology) domainSimilarity: Contains 1 SH3 domain |
Function
for NCF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCF4_HUMAN, Q15080Function: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in whichelectrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may beimportant for the assembly and/or activation of the NADPH-oxidase complex Genatlas biochemistry entry for NCF4:neutrophil cytosolic factor 4 (component of NADPH oxidase system),p40-phox,oxygen dependent mechanism of phagocytosis
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NCF4 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ncf4):
NCF4 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NCF4 (NM_013416) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF4 |
|
Pathways & Interactions
for NCF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Insulin receptor recycling | | | 3 | Lymphocyte Signaling | | | 4 | Disease | | | 5 | Cross-presentation of particulate exogenous antigens (phagosomes) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NCF4
1 
Cell Signaling Technology (CST) Pathway for NCF4
1  GeneGo (Thomson Reuters) Pathway for NCF4
5/8 
Reactome Pathways for NCF4 (see all 8)
1  PharmGKB Pathway for NCF4
4 
Kegg Pathways (Kegg details for NCF4):
NCF4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCF4
5/14 Interacting proteins for NCF4 (Q150802, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- | | GO:0006955 | immune response |
TAS | 8280052 | | GO:0007154 | cell communication |
IEA | -- | | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I |
TAS | -- |
NCF4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NCF4 for compounds About GeneDecksing
 Browse Tocris compounds for NCF4
1 HMDB Compound for NCF4 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
10/14 Novoseek chemical compound relationships for NCF4 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nadph |
88 |
66 |
9804763 (5), 9064349 (3), 9370364 (3), 10861218 (3) (see all 47) |
| phosphatidylinositol 3-phosphate |
81.6 |
16 |
18029359 (2), 11433300 (2), 18711001 (2), 17290225 (2) (see all 7) |
| superoxide |
68.2 |
14 |
18711001 (4), 9804763 (2), 17698849 (2), 9370364 (2) (see all 8) |
| oxygen |
44.6 |
2 |
8670049 (1), 14688330 (1), 17397983 (1) |
| proline |
40.8 |
5 |
8679714 (2), 15657040 (1), 11258927 (1) |
| phosphoinositide |
35 |
2 |
11433300 (1), 18711001 (1) |
| fmlp |
25 |
2 |
8670049 (2) |
| phosphatidylinositol |
15.2 |
1 |
18029359 (1) |
| phosphatidylserine |
15.1 |
1 |
12556460 (1) |
| serine |
14.8 |
7 |
11573965 (2), 15035643 (1), 9804763 (1) |
1 PharmGKB related drug/compound annotation for NCF4 gene About this tableSearch CenterWatch for drugs/clinical trials and news about NCF4
|
Transcripts
for NCF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCF4 gene (2 alternative transcripts): NM_000631.4 NM_013416.3 Unigene Cluster for NCF4: Neutrophil cytosolic factor 4, 40kDa Hs.474781 [show with all ESTs]Unigene Representative Sequence: AK0568044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447071 ENST00000248899(uc003apy.4) ENST00000397147(uc003apz.4)
ENST00000415063
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NCF4 (NM_013416) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCF4 |
Additional cDNA sequence: AB025219.1 AB025220.1 AK056804.1 AK223324.1 AK290924.1 BC002798.1 BT007346.1 CR456528.1 CR542078.1 X77094.1 6 DOTS entries: DT.113141 DT.40119985 DT.100769785 DT.91744397 DT.95350392 DT.120645867 24/145 AceView cDNA sequences (see all 145): CR616659 BX355636 BE856411 AK056804 CR456528 CD369152 AA948430 CA748910 CA308004 BI755764 CR595418 BM707869 CA436226 BI832805 AB025219 BM457144 BX443144 AI160716 BQ073024 BM466249 CR595164 BU732957 AB025220 BQ005503
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NCF4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NCF4
|
Expression
for NCF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGACGGT
About this image
See NCF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCF4
SOURCE GeneReport for Unigene cluster: Hs.474781
UniProtKB/Swiss-Prot: NCF4_HUMAN, Q15080Tissue specificity: Expression is restricted to hematopoietic cells
SABiosciences Custom PCR Arrays for NCF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF4 |
Orthologs
for NCF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NCF4 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for NCF4 (if available)
TreeFam Gene Tree for NCF4 (if available) |
Paralogs
for NCF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NCF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCF4 (37257030 - 37274059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NCF4
2 CNVs: 36025 4127
Human Gene Mutation Database (HGMD): NCF4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCF4 |
|
Disorders
/ Diseases
for NCF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCF4 for disorders About GeneDecksing
OMIM gene information: 601488
OMIM disorders: --
UniProtKB/Swiss-Prot: NCF4_HUMAN, Q15080
Defects in NCF4 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type3 (CGD3) [MIM:613960]. CGD3 is a disorder characterized by the inability of neutrophils and phagocytes to killmicrobes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections
13  diseases for NCF4: About MalaCardsnon-hodgkin lymphoma chronic granulomatous disease ornithosis hodgkin's lymphoma
rheumatoid arthritis crohn's disease leishmaniasis arthritis
meningioma breast cancer hypertension leukemia
neuronitis
1 disease from the University of Copenhagen DISEASES database for NCF4:Chronic granulomatous disease 1 Novoseek disease relationship for NCF4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| granulomatous disease chronic |
84.1 |
4 |
9064349 (1), 8670049 (1), 11433300 (1), 8147882 (1) |
Human Genome Epidemiology (HuGE) Navigator: NCF4 (18 documents)
Export disorders for NCF4 gene to outside databases
|
Publications
for NCF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCF4 gene, integrated from 9 sources (see all 132):
(articles sorted by number of sources associating them with NCF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex. (PubMed id 8839867)1, 2, 3, 9 Zhan S.... Chanock S.J. (1996)
- Identification of a splice variant mRNA of p40phox, an NADPH oxidase component of phagocytes. (PubMed id 10437784)1, 2, 9 Hasebe T.... Nagaoka I. (1999)
- p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. (PubMed id 9804763)1, 2, 9 Bouin A.-P.... Fuchs A. (1998)
- Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains. (PubMed id 15657040)1, 2, 9 Massenet C.... Fieschi F. (2005)
- p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. (PubMed id 8280052)1, 2, 9 Wientjes F.B.... Segal A.W. (1993)
- A new genetic subgroup of chronic granulomatous disea se with autosomal recessive mutations in p40 phox and selective defects in neut rophil NADPH oxidase activity. (PubMed id 19692703)1, 2 Matute J.D....Dinauer M.C. (2009)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. (PubMed id 12887891)1, 2 Wilson M.I.... Williams R.L. (2003)
- The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. (PubMed id 11684018)1, 2 Bravo J.... Williams R.L. (2001)
|
External Searches for NCF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NCF4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NCF4 gene:
Search GeneIP for patents involving NCF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for NCF4 | | OriGene shRNA RFP for NCF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCF4 | | | OriGene Protein Over-expression Lysate for NCF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCF4 | | OriGene 3'-UTR Clone for NCF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NCF4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NCF4 | | OriGene Custom Protein Services for NCF4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCF4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCF4 |
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| | Antibodies & Assays for NCF4 (p40phox) |
| | | | Search Tocris compounds for NCF4 |
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 | | | NCF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF4 |
|  |  |  |  | | | | ThermoFisher Antibody for NCF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCF4 |
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