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Aliases for NCF1B Gene

Aliases for NCF1B Gene

  • Neutrophil Cytosolic Factor 1B Pseudogene 2 3 5
  • Putative SH3 And PX Domain-Containing Protein 1B 3 4
  • SH3PXD1B 3 4
  • NCF-1B 3 4
  • Putative Neutrophil Cytosol Factor 1B 3
  • Neutrophil Cytosolic Factor 1B 2

External Ids for NCF1B Gene

Previous GeneCards Identifiers for NCF1B Gene

  • GC07U901696
  • GC07P072274
  • GC07P072635
  • GC07P071968

Summaries for NCF1B Gene

GeneCards Summary for NCF1B Gene

NCF1B (Neutrophil Cytosolic Factor 1B Pseudogene) is a Pseudogene. Diseases associated with NCF1B include Chronic Granulomatous Disease. GO annotations related to this gene include phosphatidylinositol binding and superoxide-generating NADPH oxidase activity.

UniProtKB/Swiss-Prot for NCF1B Gene

  • May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCF1B Gene

Genomics for NCF1B Gene

Regulatory Elements for NCF1B Gene

Enhancers for NCF1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NCF1B on UCSC Golden Path with GeneCards custom track

Promoters for NCF1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NCF1B Gene

Chromosome:
7
Start:
73,220,624 bp from pter
End:
73,235,945 bp from pter
Size:
15,322 bases
Orientation:
Plus strand

Genomic View for NCF1B Gene

Genes around NCF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCF1B Gene

Proteins for NCF1B Gene

  • Protein details for NCF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI72-NCF1B_HUMAN
    Recommended name:
    Putative neutrophil cytosol factor 1B
    Protein Accession:
    A6NI72

    Protein attributes for NCF1B Gene

    Size:
    391 amino acids
    Molecular mass:
    44817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCF1B Gene

Post-translational modifications for NCF1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for NCF1B Gene

Domains & Families for NCF1B Gene

Protein Domains for NCF1B Gene

Suggested Antigen Peptide Sequences for NCF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NI72

UniProtKB/Swiss-Prot:

NCF1B_HUMAN :
  • Contains 1 PX (phox homology) domain.
Domain:
  • Contains 1 PX (phox homology) domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with NCF1B: view

No data available for Gene Families for NCF1B Gene

Function for NCF1B Gene

Molecular function for NCF1B Gene

UniProtKB/Swiss-Prot Function:
May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Gene Ontology (GO) - Molecular Function for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016175 superoxide-generating NADPH oxidase activity IEA --
GO:0016176 superoxide-generating NADPH oxidase activator activity IBA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with NCF1B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCF1B Gene

Localization for NCF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCF1B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0043020 NADPH oxidase complex IBA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Subcellular locations from COMPARTMENTS for NCF1B Gene

Pathways & Interactions for NCF1B Gene

SuperPathways for NCF1B Gene

No Data Available

Interacting Proteins for NCF1B Gene

Gene Ontology (GO) - Biological Process for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IBA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0045730 respiratory burst IBA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Pathways by source and SIGNOR curated interactions for NCF1B Gene

Drugs & Compounds for NCF1B Gene

(1) Additional Compounds for NCF1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with NCF1B: view

Transcripts for NCF1B Gene

mRNA/cDNA for NCF1B Gene

(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCF1B Gene

Neutrophil cytosolic factor 1B pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCF1B Gene

No ASD Table

Relevant External Links for NCF1B Gene

GeneLoc Exon Structure for
NCF1B
ECgene alternative splicing isoforms for
NCF1B

Expression for NCF1B Gene

mRNA expression in normal human tissues for NCF1B Gene

mRNA differential expression in normal tissues according to GTEx for NCF1B Gene

This gene is overexpressed in Whole Blood (x33.4) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for NCF1B Gene

This gene is overexpressed in Cervix (34.5), Peripheral blood mononuclear cells (23.7), and Neutrophil (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCF1B Gene



Protein tissue co-expression partners for NCF1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCF1B Gene:

NCF1B

SOURCE GeneReport for Unigene cluster for NCF1B Gene:

Hs.655201
genes like me logo Genes that share expression patterns with NCF1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NCF1B Gene

Orthologs for NCF1B Gene

Evolution for NCF1B Gene

ENSEMBL:
Gene Tree for NCF1B (if available)
TreeFam:
Gene Tree for NCF1B (if available)

No data available for Orthologs for NCF1B Gene

Paralogs for NCF1B Gene

(6) SIMAP similar genes for NCF1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCF1B: view

No data available for Paralogs for NCF1B Gene

Variants for NCF1B Gene

Sequence variations from dbSNP and Humsavar for NCF1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2428791 -- 73,232,427(-) gaatc(A/G)cttca intron-variant
rs2429071 -- 73,235,219(-) ATCCA(C/T)CAGCG nc-transcript-variant
rs2523325 -- 73,226,761(+) GGGTC(C/T)GCTCC intron-variant
rs2528940 -- 73,229,418(+) AACAA(A/G)GACAT intron-variant
rs13447 -- 73,225,925(-) GAACC(A/C/G/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCF1B Gene

Variant ID Type Subtype PubMed ID
esv2759537 CNV gain+loss 17122850
esv2764061 CNV gain+loss 21179565
esv34349 CNV gain 17911159
esv3613678 CNV loss 21293372
nsv1023115 CNV gain 25217958
nsv1029162 CNV loss 25217958
nsv1161563 CNV deletion 26073780
nsv428171 CNV gain 18775914
nsv520573 CNV gain+loss 19592680
nsv8139 CNV gain 18304495
nsv831027 CNV loss 17160897
nsv981526 CNV duplication 23825009

Relevant External Links for NCF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NCF1B Gene

Disorders for NCF1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCF1B Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic granulomatous disease
  • bridges-good syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NCF1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCF1B

Genetic Association Database (GAD)
NCF1B
Human Genome Epidemiology (HuGE) Navigator
NCF1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCF1B
genes like me logo Genes that share disorders with NCF1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCF1B Gene

Publications for NCF1B Gene

  1. NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PMID: 19077231) Greve B. … Kremsner P.G. (Malar. J. 2008) 3 46 65
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 65
  3. Functional pseudogenes inhibit the superoxide production. (PMID: 26086043) Xu W. … Song Q. (Precis Med 2015) 3 65
  4. Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PMID: 16720733) Dang P.M. … El-Benna J. (FASEB J. 2006) 3 65
  5. Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 degrees chronic granulomatous disease carrier detection. (PMID: 12176908) Heyworth P.G. … Cross A.R. (Blood 2002) 3 65

Products for NCF1B Gene

Sources for NCF1B Gene

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