|
|
neutrophil cytosolic factor 1B pseudogene(Previous name: neutrophil cytosolic factor 1B )
| |
Aliases
for NCF1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
|---|
| Neutrophil Cytosolic Factor 1B Pseudogene1 2 | | SH3PXD1B1 2 3 | | NCF-1B2 3 | | Neutrophil Cytosolic Factor 1B1 | | Putative SH3 And PX Domain-Containing Protein 1B3 |
| External Ids: | HGNC: 325221 | Entrez Gene: 6548162 | Ensembl: ENSG000001824877 | UniProtKB: A6NI723 |
Export aliases for NCF1B gene to outside databasesPrevious GC identifers: GC07U901696 GC07P072274 GC07P071968
|---|
Summaries
for NCF1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NCF1B_HUMAN, A6NI72Function: May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (Bysimilarity)
fRNAdb sequence ontology for NCF1B:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
View fRNAdb secondary structures for NCF1B |
Genomic Views
for NCF1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCF1B gene promoter:
HOXA9B TBP Pbx1a AP-1 Cdc5 LCR-F1 YY1 MEF-2A MZF-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCF1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCF1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23NCF1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P072635: view genomic region
(about GC identifiers)
Start:
|
72,634,611 bp from pter |
End:
|
72,649,979 bp from pter |
Size:
|
15,369 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 71,967,746-71,983,051 |
ORGUL member locations:
Legend (see complete legend)
72634673 72642326 72649979 chr7
|
Proteins
for NCF1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCF1B_HUMAN, A6NI72 (See
protein sequence)Recommended Name: Putative neutrophil cytosol factor 1B Size: 391 amino acids; 44817 Da
Subcellular location: Cytoplasm (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for NCF1B: NX_A6NI72
NCF1B Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NCF1B for ontologies About GeneDecksing
NCF1B Antibody Products:
Assay Products for NCF1B: |
Protein
Domains /
Families
for NCF1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCF1B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NI72ProtoNet protein and cluster: A6NI72 UniProtKB/Swiss-Prot: NCF1B_HUMAN, A6NI72Similarity: Contains 1 PX (phox homology) domainSimilarity: Contains 2 SH3 domains |
Function
for NCF1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NCF1B_HUMAN, A6NI72Function: May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (Bysimilarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016175 | superoxide-generating NADPH oxidase activity |
IEA | -- | | GO:0035091 | phosphatidylinositol binding |
IEA | -- |
NCF1B for ontologies About GeneDecksing
|
Pathways & Interactions
for NCF1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCF1B
5/8 Interacting proteins for NCF1B (A6NI723) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- |
NCF1B for ontologies About GeneDecksing
|
Drugs & Compounds
for NCF1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NCF1B
1 HMDB Compound for NCF1B About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
Search CenterWatch for drugs/clinical trials and news about NCF1B 
|
Transcripts
for NCF1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 1 fRNAdb Secondary structure:
Unigene Cluster for NCF1B: Neutrophil cytosolic factor 1B pseudogene Hs.655201 [show with all ESTs]Unigene Representative Sequence: BM4552956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432102 ENST00000423083(uc022afs.1) ENST00000435988 ENST00000338578
ENST00000543901(uc011ker.1) ENST00000541521
Additional cDNA sequence: AK292094.1 AK298655.1 AK316329.1 AK316341.1 BC080194.1 NR_003186.1 NR_003187.2 22 DOTS entries: DT.99981388 DT.95329095 DT.95329092 DT.102840657 DT.121058223 DT.450452 DT.92440157 DT.121058296 DT.100815103 DT.121057774 DT.95096374 DT.95329093 DT.97846804 DT.100705888 DT.100815101 DT.121057687 DT.100815093 DT.100815106 DT.101982114 DT.121041970 DT.121057758 DT.97822017
GeneLoc Exon Structure
|
Expression
for NCF1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NCF1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCF1B
SOURCE GeneReport for Unigene cluster: Hs.655201
SABiosciences Custom PCR Arrays for NCF1B
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCF1B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NCF1B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCF1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCF1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF1B |
Orthologs
for NCF1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NCF1B (if available)
TreeFam Gene Tree for NCF1B (if available) |
Paralogs
for NCF1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NCF1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCF1B (72634611 - 72649979 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NCF1B
4 CNVs: 2699 3685 31359 8567 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NCF1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCF1B for disorders About GeneDecksing
OMIM gene information: 141400 605635 608512
1  disease for NCF1B: About MalaCardschronic granulomatous disease
Human Genome Epidemiology (HuGE) Navigator: NCF1B (1 document)
Export disorders for NCF1B gene to outside databases
|
Publications
for NCF1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCF1B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NCF1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PubMed id 19077231)1 Greve B....Kremsner P.G. (2008)
- Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PubMed id 16720733)1 Dang P.M....El-Benna J. (2006)
- Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 degrees chronic granulomatous disease carrier detection. (PubMed id 12176908)1 Heyworth P.G....Cross A.R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Genomic structure of the human p47-phox (NCF1) gene. (PubMed id 10772875)1 Chanock S.J.... Goerlach A. (2000)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
- A p47-phox pseudogene carries the most common mutation causing p47- phox-deficient chronic granulomatous disease. (PubMed id 9329953)1 Gorlach A.... Curnutte J.T. (1997)
- (PubMed id 15103394)10
- (PubMed id 18089548)10
|
External Searches for NCF1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NCF1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NCF1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NCF1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NCF1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NCF1B gene:
Search GeneIP for patents involving NCF1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NCF1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCF1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCF1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCF1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCF1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCF1B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCF1B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NCF1B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCF1B |
|  |  |  | | | | Search ThermoFisher Antibodies for NCF1B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NCF1B |
|
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 100 solr: 1.4
|
