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Aliases for NCF1B Gene

Aliases for NCF1B Gene

  • Neutrophil Cytosolic Factor 1B Pseudogene 2 3
  • Putative SH3 And PX Domain-Containing Protein 1B 3 4
  • SH3PXD1B 3 4
  • NCF-1B 3 4
  • Putative Neutrophil Cytosol Factor 1B 3
  • Neutrophil Cytosolic Factor 1B 2

External Ids for NCF1B Gene

Summaries for NCF1B Gene

GeneCards Summary for NCF1B Gene

NCF1B (Neutrophil Cytosolic Factor 1B Pseudogene) is a Pseudogene. Diseases associated with NCF1B include chronic granulomatous disease. GO annotations related to this gene include phosphatidylinositol binding and superoxide-generating NADPH oxidase activity.

UniProtKB/Swiss-Prot for NCF1B Gene

  • May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCF1B Gene

Genomics for NCF1B Gene

Genomic Location for NCF1B Gene

Start:
73,220,624 bp from pter
End:
73,235,945 bp from pter
Size:
15,322 bases
Orientation:
Plus strand

Genomic View for NCF1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCF1B Gene

Regulatory Elements for NCF1B Gene

Proteins for NCF1B Gene

  • Protein details for NCF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI72-NCF1B_HUMAN
    Recommended name:
    Putative neutrophil cytosol factor 1B
    Protein Accession:
    A6NI72
    Secondary Accessions:

    Protein attributes for NCF1B Gene

    Size:
    391 amino acids
    Molecular mass:
    44817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCF1B Gene

Proteomics data for NCF1B Gene at MOPED

Post-translational modifications for NCF1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for NCF1B Gene

Domains for NCF1B Gene

Protein Domains for NCF1B Gene

UniProtKB/Swiss-Prot:

NCF1B_HUMAN
Domain:
  • Contains 1 PX (phox homology) domain.:
    • A6NI72
  • Contains 2 SH3 domains.:
    • A6NI72
genes like me logo Genes that share domains with NCF1B: view

No data available for Gene Families for NCF1B Gene

Function for NCF1B Gene

Molecular function for NCF1B Gene

UniProtKB/Swiss-Prot Function: May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Gene Ontology (GO) - Molecular Function for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016175 superoxide-generating NADPH oxidase activity IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCF1B Gene

Localization for NCF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCF1B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NCF1B: view

Pathways for NCF1B Gene

SuperPathways for NCF1B Gene

No Data Available

Interacting Proteins for NCF1B Gene

Selected Interacting proteins: A6NI72-NCF1B_HUMAN for NCF1B Gene via I2D

Gene Ontology (GO) - Biological Process for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Pathways by source for NCF1B Gene

Compounds for NCF1B Gene

(1) HMDB Compounds for NCF1B Gene

Compound Synonyms Cas Number PubMed IDs
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
genes like me logo Genes that share compounds with NCF1B: view

Transcripts for NCF1B Gene

mRNA/cDNA for NCF1B Gene

(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCF1B Gene

Neutrophil cytosolic factor 1B pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCF1B Gene

No ASD Table

Relevant External Links for NCF1B Gene

GeneLoc Exon Structure for
NCF1B
ECgene alternative splicing isoforms for
NCF1B

Expression for NCF1B Gene

mRNA expression in normal human tissues for NCF1B Gene

mRNA differential expression in normal tissues according to GTEx for NCF1B Gene

This gene is overexpressed in Whole Blood (33.4) and Spleen (5.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NCF1B Gene

SOURCE GeneReport for Unigene cluster for NCF1B Gene Hs.655201

genes like me logo Genes that share expressions with NCF1B: view

Orthologs for NCF1B Gene

Evolution for NCF1B Gene

ENSEMBL:
Gene Tree for NCF1B (if available)
TreeFam:
Gene Tree for NCF1B (if available)

No data available for Orthologs for NCF1B Gene

Paralogs for NCF1B Gene

Selected SIMAP similar genes for NCF1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCF1B: view

No data available for Paralogs for NCF1B Gene

Variants for NCF1B Gene

Sequence variations from dbSNP and Humsavar for NCF1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs697669 -- 73,220,038(+) actgc(A/G)cttaa upstream-variant-2KB
rs707362 -- 73,232,801(+) GAGGC(A/T)GCAGT intron-variant
rs800018 -- 73,226,670(+) AGCAC(C/T)TATTG intron-variant
rs800982 -- 73,229,110(+) tccac(A/G)cctgt intron-variant
rs1637120 -- 73,226,873(+) CCTGA(A/G)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCF1B Gene

Variant ID Type Subtype PubMed ID
dgv2095e1 CNV Complex 17122850
nsv520573 CNV Gain+Loss 19592680
esv34349 CNV Gain 17911159
dgv2098e1 CNV Complex 17122850
nsv428171 CNV Gain 18775914
dgv2099e1 CNV Complex 17122850
nsv888362 CNV Gain 21882294
esv2734660 CNV Deletion 23290073
nsv831027 CNV Loss 17160897
nsv8139 CNV Gain 18304495

Relevant External Links for NCF1B Gene

HapMap Linkage Disequilibrium report
NCF1B

Disorders for NCF1B Gene

Relevant External Links for NCF1B

Genetic Association Database (GAD)
NCF1B
Human Genome Epidemiology (HuGE) Navigator
NCF1B
genes like me logo Genes that share disorders with NCF1B: view

No data available for UniProtKB/Swiss-Prot for NCF1B Gene

Publications for NCF1B Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PMID: 19077231) Greve B. … Kremsner P.G. (Malar. J. 2008) 3 49
  3. Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PMID: 16720733) Dang P.M. … El-Benna J. (FASEB J. 2006) 3
  4. A p47-phox pseudogene carries the most common mutation causing p47- phox-deficient chronic granulomatous disease. (PMID: 9329953) Gorlach A. … Curnutte J.T. (J. Clin. Invest. 1997) 3
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for NCF1B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate NCF1B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NCF1B
    • Block miRNA regulation of NCF1B using miScript Target Protectors

    Sources for NCF1B Gene

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