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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCEH1 Gene

protein-coding   GIFtS: 54
GCID: GC03M172348

neutral cholesterol ester hydrolase 1

(Previous name: arylacetamide deacetylase-like 1 )
(Previous symbol: AADACL1)
 Explore 9 diseases affiliated with
NCEH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NCEH1    

Aliases
for NCEH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neutral Cholesterol Ester Hydrolase 11 2     KIAA13631 3 5
NCEH1 2 3 5     EC 3.1.1.-3
Arylacetamide Deacetylase-Like 11 2 3     EC 3.1.18
AADACL11 2 3     EC 3.1.1.798

External Ids:    HGNC: 292601   Entrez Gene: 575522   Ensembl: ENSG000001449597   OMIM: 6132345   UniProtKB: Q6PIU23   

Export aliases for NCEH1 gene to outside databases

Previous GC identifers: GC03M173833 GC03M169719


Summaries
for NCEH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NCEH1_HUMAN, Q6PIU2
Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis
of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby
contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous
organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration

Gene Wiki entry for NCEH1


Genomic Views
for NCEH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NCEH1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCEH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCEH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCEH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.31   Ensembl cytogenetic band:  3q26.31   HGNC cytogenetic band: 3q26.31

NCEH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCEH1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M172348:  view genomic region     (about GC identifiers)

Start:
 172,348,039 bp from pter      End:
 172,429,008 bp from pter
Size:
 80,970 bases      Orientation:
 minus strand

Proteins
for NCEH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NCEH1_HUMAN, Q6PIU2 (See protein sequence)
Recommended Name: Neutral cholesterol ester hydrolase 1  
Size: 408 amino acids; 45808 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Probable). Microsome (By similarity)
Sequence caution: Sequence=AAH28734.2; Type=Erroneous initiation; Sequence=AAH47588.2; Type=Erroneous initiation;
Sequence=BAA92601.1; Type=Erroneous initiation; Sequence=BAH13028.1; Type=Erroneous initiation; Sequence=BAH14142.1;
Type=Erroneous initiation; Sequence=BAH14802.1; Type=Erroneous initiation;
Secondary accessions: B7Z2K4 B7Z3A1 B7Z5U2 B7Z906 B7ZAW6 Q86WZ1 Q9P2I4
Alternative splicing: 3 isoforms:  Q6PIU2-1   Q6PIU2-2   Q6PIU2-3   

Explore the universe of human proteins at neXtProt for NCEH1: NX_Q6PIU2

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PIU2

    • 4/11 DME Specific Peptides for NCEH1 (Q6PIU2) (see all 11)
     LGLSHHL  SFGKKSA  DVLRDDG  PKPEEPL 

    NCEH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001139748.1  NP_001139749.1  NP_001139750.1  NP_065843.3  

    ENSEMBL proteins: 
     ENSP00000418571   ENSP00000392934   ENSP00000402196   ENSP00000442464   ENSP00000273512  
     ENSP00000443227  

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    Novus Biologicals NCEH1 Protein
    Novus Biologicals NCEH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NCEH1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005792microsome ----
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    NCEH1 for ontologies           About GeneDecksing



    NCEH1 Antibody Products: 
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    Uscn Antibodies for NCEH1
    ThermoFisher Antibodies for NCEH1

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    Uscn ELISAs and CLIAs for NCEH1

    Protein Domains /
    Families
    for NCEH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NCEH1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017157 Arylacetamide_deacetylase
     IPR013094 AB_hydrolase_3
     IPR002168 Lipase_GDXG_AS

    Graphical View of Domain Structure for InterPro Entry Q6PIU2

    ProtoNet protein and cluster: Q6PIU2

    2 Blocks protein families:
    IPB002168 Lipolytic enzyme
    IPB013094 Alpha/beta hydrolase fold-3


    UniProtKB/Swiss-Prot: NCEH1_HUMAN, Q6PIU2
    Similarity: Belongs to the 'GDXG' lipolytic enzyme family


    Function
    for NCEH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NCEH1_HUMAN, Q6PIU2
    Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis
    of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby
    contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous
    organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration

    Enzyme Numbers (IUBMB): EC 3.1.12 EC 3.1.1.-1 EC 3.1.1.792

    miRNA
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    hsa-mir-30a (MIRT005151)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCEH1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate NCEH1 (see all 37):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-449a hsa-miR-93 hsa-miR-330-3p hsa-miR-526b* hsa-miR-1290 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: NCEH1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCEH1 (see all 4)
    OriGene shRNA RFP: NCEH1
    OriGene siRNA: NCEH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCEH1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NCEH1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCEH1 (see all 6)
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    Cell Line
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    Search LifeMap BioReagents cell lines for NCEH1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCEH1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IEA--
    GO:0017171serine hydrolase activity ----
    GO:0042301phosphate ion binding ----


    NCEH1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NCEH1: Nceh1tm1Ishi Nceh1tm1Jcsd
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nceh1):
     cardiovascular system  cellular  homeostasis/metabolism  immune system 

    NCEH1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NCEH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Bile secretion
    		Bile secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NCEH1):
        Bile secretion


    NCEH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCEH1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0006805xenobiotic metabolic process ----
    GO:0016042lipid catabolic process IEA--


    NCEH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCEH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCEH1

    10/31 HMDB Compounds for NCEH1 (see all 31)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CE(10:0)Decanoic acid cholesteryl ester (see all 18)1183-04-6--
    CE(12:0)cholest-5-en-3beta-yl dodecanoate (see all 19)1908-11-8--
    CE(14:0)14:0 Cholesterol ester (see all 24)1989-52-2--
    CE(14:1(9Z))CE(14:1/0:0) (see all 22)----
    CE(16:0)Cholest-5-ene-3-beta-yl palmitate (see all 23)601-34-3--
    CE(16:1(9Z))(Z)-Cholesterol 9-hexadecenoate (see all 33)16711-66-3--
    CE(18:0)cholesterol 1-octadecanoate (see all 14)----
    CE(18:1(11Z))cholesterol 1-(11Z-octadecenoate) (see all 25)----
    CE(18:1(9Z))3beta-Hydroxy-5-cholestene 3-oleate (see all 35)303-43-5--
    CE(18:2(9Z,12Z))cholesterol 1-linoleoic acid (see all 25)604-33-1--
    Search CenterWatch for drugs/clinical trials and news about NCEH1 

    Transcripts
    for NCEH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCEH1 gene (4 alternative transcripts): 
    NM_001146276.1  NM_001146277.1  NM_001146278.1  NM_020792.4  

    Unigene Cluster for NCEH1:

    Neutral cholesterol ester hydrolase 1
    Hs.444099  [show with all ESTs]
    Unigene Representative Sequence: BC028734
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475381 ENST00000470419 ENST00000424772 ENST00000421723 ENST00000538775(uc011bpx.2)
    ENST00000273512(uc003fig.3 uc011bpw.2) ENST00000543711(uc011bpy.2)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCEH1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate NCEH1 (see all 37):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-449a hsa-miR-93 hsa-miR-330-3p hsa-miR-526b* hsa-miR-1290 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: NCEH1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCEH1 (see all 4)
    OriGene shRNA RFP: NCEH1
    OriGene siRNA: NCEH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCEH1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCEH1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): NCEH1 (NM_020792)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCEH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCEH1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCEH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCEH1

    Additional cDNA sequence: 

    AB037784.1 AK294811.1 AK295641.1 AK299422.1 AK304253.1 AK316431.1 AL512752.1 BC028734.1 
    BC047588.1 

    9 DOTS entries:

    DT.446475  DT.100774528  DT.95302321  DT.97777363  DT.100774526  DT.100774527  DT.120896588  DT.120896590 
    DT.120896610 

    24/97 AceView cDNA sequences (see all 97):

    AW192003 BE218940 AA625233 BX281107 AI859996 AI052302 BM968147 BX378214 
    AI192253 AI419800 BQ009207 NM_020792 R99544 D82480 CB138758 AA971330 
    BG117690 R20244 AB037784 D82564 BI753815 BM712744 AL512752 CF552026 

    GeneLoc Exon Structure


    Expression
    for NCEH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCEH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGGAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NCEH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NCEH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCEH1

    SOURCE GeneReport for Unigene cluster: Hs.444099

    UniProtKB/Swiss-Prot: NCEH1_HUMAN, Q6PIU2
    Tissue specificity: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma
    cell lines

        SABiosciences Custom PCR Arrays for NCEH1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCEH1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCEH1

    Orthologs
    for NCEH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NCEH1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NCEH11 neutral cholesterol ester hydrolase 1 72.55(n)
    71.08(a)    		   429158  XM_426713.3  XP_426713.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NCEH16
    		 --
    		 66(a)
    		 1 ↔ 1
    		 3(6182716-6195254)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.334372 Xenopus laevis transcribed sequence with weak similarity more 74.38(n)    BJ639146.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7974361 neutral cholesterol ester hydrolase 1-like 56.92(n)
    50.61(a)    		   797436  XM_001335346.2  XP_001335382.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43F8A.36
    T09B9.16
    (see all 4)    		 Protein T09B9.1
    (see all 4)    		 25(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 V(19377415-19381002)
    X(9757213-9759251)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria aes6
    		 acetyl esterase
    		 18(a)
    		 possible ortholog
    		 Chromosome(498238-499197)


    ENSEMBL Gene Tree for NCEH1 (if available)
    TreeFam Gene Tree for NCEH1 (if available) 

    Paralogs
    for NCEH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCEH1 gene
    AADAC2  AADACL42  LIPE2  AADACL32  AADACL22  
    4 SIMAP similar genes for NCEH1 using alignment to 5 protein entries:     NCEH1_HUMAN (see all proteins):
    AADAC    AADACL2    AADACL3    AADACL4

    NCEH1 for paralogs           About GeneDecksing



    Genomic Variants
    for NCEH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1633 NCBI SNPs in NCEH1 are shown (see all 1633)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1856866361,2
    		--172348020(+) TGACAC/TAAACT 4 -- int10--------
    rs1893785161,2
    		--172348056(+) TTAGAC/TTTATT 4 -- int10--------
    rs1806860461,2
    		--172348062(+) TTATTC/TGTAAT 4 -- int10--------
    rs1851172701,2
    		--172348253(+) ATACTA/GTATCC 4 -- int10--------
    rs1400310371,2
    		--172348420(+) CAGAAA/GATGAG 4 -- int10--------
    rs1900693971,2
    		--172348428(+) GAGACA/GGGAAA 4 -- int10--------
    rs130644031,2
    		C,H--172348612(+) AAAGGT/CCATGC 4 -- ut314Minor allele frequency- C:0.00EA NS NA 302
    rs1452150931,2
    		--172348651(+) TAATAC/GTCTTA 4 -- ut310--------
    rs679822291,2
    		C,--172348744(+) ATTTC-/ACAG  
                ACAAT     		4 -- ut310--------
    rs1408800481,2
    		C,--172348906(+) GTTGA-/CCTC  
                CCTCT     		4 -- ut310--------

    HapMap Linkage Disequilibrium report for NCEH1 (172348039 - 172429008 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NCEH1
         1 CNV: 53457
         1 Indel: 40580

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    Disorders / Diseases
    for NCEH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NCEH1 for disorders           About GeneDecksing

    OMIM gene information: 613234    OMIM disorders: --

    9 diseases for NCEH1:    About MalaCards
    cholesterol    hermaphroditism    infertility    breast carcinoma
    atherosclerosis    tuberculosis    melanoma    carcinoma
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: NCEH1 (0 documents)

    Export disorders for NCEH1 gene to outside databases

    Publications
    for NCEH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCEH1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with NCEH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. (PubMed id 18782767)1, 2 Okazaki H....Ishibashi S. (2008)
    3. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. (PubMed id 17052608)1, 2 Chiang K.P.... Cravatt B.F. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    7. Investigation of low-dose ritonavir on human peripher al blood mononuclear cells using gene expression whole genome microarrays. (PubMed id 20353815)1 Yilmaz S....McGregor J.L. (2010)
    8. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    9. The critical role of neutral cholesterol ester hydrol ase 1 in cholesterol removal from human macrophages. (PubMed id 20947831)1 Igarashi M....Ishibashi S. (2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    External Searches for NCEH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing NCEH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57552 HGNC: 29260 AceView: KIAA1363 Ensembl:ENSG00000144959 euGenes: HUgn57552
    ECgene: NCEH1 Kegg: 57552 H-InvDB: NCEH1

    Other Databases showing NCEH1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1363

    Specialized Databases showing NCEH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCEH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NCEH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCEH1 gene:
    Search GeneIP for patents involving NCEH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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