Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCEH1 Gene

Aliases for NCEH1 Gene

  • Neutral Cholesterol Ester Hydrolase 1 2 3
  • Arylacetamide Deacetylase-Like 1 2 3 4
  • AADACL1 3 4
  • NCEH 3 4
  • EC 3.1.1.79 63
  • EC 3.1.1.- 4
  • KIAA1363 4
  • EC 3.1.1 63

External Ids for NCEH1 Gene

Previous HGNC Symbols for NCEH1 Gene

  • AADACL1

Previous GeneCards Identifiers for NCEH1 Gene

  • GC03M173833
  • GC03M172348
  • GC03M169719

Summaries for NCEH1 Gene

GeneCards Summary for NCEH1 Gene

NCEH1 (Neutral Cholesterol Ester Hydrolase 1) is a Protein Coding gene. Among its related pathways are Bile secretion. GO annotations related to this gene include hydrolase activity and phosphate ion binding. An important paralog of this gene is AADAC.

UniProtKB/Swiss-Prot for NCEH1 Gene

  • Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.

Gene Wiki entry for NCEH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCEH1 Gene

Genomics for NCEH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCEH1 Gene

Chromosome:
3
Start:
172,630,249 bp from pter
End:
172,711,218 bp from pter
Size:
80,970 bases
Orientation:
Minus strand

Genomic View for NCEH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCEH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCEH1 Gene

No data available for Regulatory Elements for NCEH1 Gene

Proteins for NCEH1 Gene

  • Protein details for NCEH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIU2-NCEH1_HUMAN
    Recommended name:
    Neutral cholesterol ester hydrolase 1
    Protein Accession:
    Q6PIU2
    Secondary Accessions:
    • B7Z2K4
    • B7Z3A1
    • B7Z5U2
    • B7Z906
    • B7ZAW6
    • F5H7K4
    • Q86WZ1
    • Q9P2I4

    Protein attributes for NCEH1 Gene

    Size:
    408 amino acids
    Molecular mass:
    45808 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28734.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47588.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AC007919; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AC069237; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA92601.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH13028.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH14142.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH14802.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCEH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCEH1 Gene

Proteomics data for NCEH1 Gene at MOPED

Post-translational modifications for NCEH1 Gene

Domains & Families for NCEH1 Gene

Suggested Antigen Peptide Sequences for NCEH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIU2

UniProtKB/Swiss-Prot:

NCEH1_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with NCEH1: view

No data available for Gene Families for NCEH1 Gene

Function for NCEH1 Gene

Molecular function for NCEH1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.

Enzyme Numbers (IUBMB) for NCEH1 Gene

Gene Ontology (GO) - Molecular Function for NCEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0017171 serine hydrolase activity --
GO:0042301 phosphate ion binding --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with NCEH1: view
genes like me logo Genes that share phenotypes with NCEH1: view

Animal Models for NCEH1 Gene

MGI Knock Outs for NCEH1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCEH1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NCEH1 Gene

Localization for NCEH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCEH1 Gene

Membrane; Single-pass type II membrane protein. Microsome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCEH1 Gene COMPARTMENTS Subcellular localization image for NCEH1 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NCEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCEH1: view

Pathways & Interactions for NCEH1 Gene

SuperPathways for NCEH1 Gene

Superpath Contained pathways
1 Bile secretion
genes like me logo Genes that share pathways with NCEH1: view

Pathways by source for NCEH1 Gene

1 KEGG pathway for NCEH1 Gene

Interacting Proteins for NCEH1 Gene

Gene Ontology (GO) - Biological Process for NCEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0006805 xenobiotic metabolic process --
GO:0008152 metabolic process --
GO:0016042 lipid catabolic process IEA --
GO:0060395 SMAD protein signal transduction --
genes like me logo Genes that share ontologies with NCEH1: view

No data available for SIGNOR curated interactions for NCEH1 Gene

Drugs & Compounds for NCEH1 Gene

(31) Additional Compounds for NCEH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(10:0)
  • 3b-(Decanoyloxy)-5-cholestene
  • 5-Cholesten-3b-ol caprate
  • Cholest-5-en-3b-ol caprate
  • Cholesterol 3-decanoate
  • Cholesterol 3-decanoic acid
1183-04-6
CE(12:0)
  • (3beta)-Cholest-5-en-3-ol dodecanoate
  • (3beta)-Cholest-5-en-3-ol dodecanoic acid
  • 12:0 Cholesterol ester
  • Cholest-5-en-3-beta-yl laurate
  • Cholest-5-en-3-yl laurate
1908-11-8
CE(14:0)
  • 1-Myristoyl-cholesterol
  • 14:0 Cholesterol ester
  • CE(14:0)
  • CE(14:0/0:0)
  • Cholest-5-en-3-ol (3beta)-tetradecanoate
1989-52-2
CE(14:1(9Z))
  • 1-Myristoleoyl-cholesterol
  • 14:1(9Z) Cholesterol ester
  • CE(14:1)
  • CE(14:1/0:0)
  • CE(14:1n5/0:0)
CE(16:0)
  • 1-Palmitoyl-cholesterol
  • 16:0 Cholesterol ester
  • Cholest-5-en-3-yl palmitate
  • Cholest-5-ene-3-beta-yl palmitate
  • Cholesterol 1-hexadecanoate
601-34-3
genes like me logo Genes that share compounds with NCEH1: view

Transcripts for NCEH1 Gene

Unigene Clusters for NCEH1 Gene

Neutral cholesterol ester hydrolase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCEH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCEH1 Gene

No ASD Table

Relevant External Links for NCEH1 Gene

GeneLoc Exon Structure for
NCEH1
ECgene alternative splicing isoforms for
NCEH1

Expression for NCEH1 Gene

mRNA expression in normal human tissues for NCEH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCEH1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for NCEH1 Gene

This gene is overexpressed in Islet of Langerhans (11.2), Lymph node (9.5), and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCEH1 Gene



SOURCE GeneReport for Unigene cluster for NCEH1 Gene Hs.444099

mRNA Expression by UniProt/SwissProt for NCEH1 Gene

Q6PIU2-NCEH1_HUMAN
Tissue specificity: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
genes like me logo Genes that share expression patterns with NCEH1: view

Protein tissue co-expression partners for NCEH1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for NCEH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCEH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCEH1 35
  • 89.54 (n)
  • 92.65 (a)
NCEH1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCEH1 35
  • 87.34 (n)
  • 92.65 (a)
NCEH1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nceh1 35
  • 82.27 (n)
  • 87.01 (a)
Nceh1 16
Nceh1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCEH1 35
  • 98.56 (n)
  • 98.18 (a)
NCEH1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nceh1 35
  • 82.68 (n)
  • 86.76 (a)
oppossum
(Monodelphis domestica)
Mammalia NCEH1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves NCEH1 35
  • 72.06 (n)
  • 70.59 (a)
NCEH1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCEH1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5783 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33437 35
zebrafish
(Danio rerio)
Actinopterygii nceh1b 35
  • 56.18 (n)
  • 50.64 (a)
CR376848.1 36
  • 50 (a)
OneToMany
nceh1a 36
  • 50 (a)
OneToMany
nceh1b 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T09B9.1 35
  • 46.75 (n)
  • 35.46 (a)
F16F9.4 36
  • 24 (a)
ManyToMany
T09B9.1 36
  • 25 (a)
ManyToMany
trcs-1 36
  • 25 (a)
ManyToMany
Y43F8A.3 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for NCEH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCEH1 Gene

ENSEMBL:
Gene Tree for NCEH1 (if available)
TreeFam:
Gene Tree for NCEH1 (if available)

Paralogs for NCEH1 Gene

Paralogs for NCEH1 Gene

(4) SIMAP similar genes for NCEH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NCEH1: view

Variants for NCEH1 Gene

Sequence variations from dbSNP and Humsavar for NCEH1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs98106 -- 172,644,917(-) ACCCA(C/T)GTTCC intron-variant
rs170883 -- 172,648,691(-) TTGAC(A/C)ATGTT intron-variant
rs233999 -- 172,649,259(-) TATAT(A/G)TGTGT intron-variant
rs234000 -- 172,649,129(-) ACGGA(A/C)CCTCT intron-variant
rs234001 -- 172,648,369(-) GAAAT(G/T)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCEH1 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
dgv627n27 CNV Gain 19166990
nsv471060 CNV Gain 18288195
nsv4118 CNV Insertion 18451855
esv2726213 CNV Deletion 23290073
esv2726214 CNV Deletion 23290073
esv274529 CNV Insertion 20981092
nsv518366 CNV Loss 19592680
nsv877990 CNV Loss 21882294

Variation tolerance for NCEH1 Gene

Residual Variation Intolerance Score: 20.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCEH1 Gene

HapMap Linkage Disequilibrium report
NCEH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCEH1 Gene

Disorders for NCEH1 Gene

Relevant External Links for NCEH1

Genetic Association Database (GAD)
NCEH1
Human Genome Epidemiology (HuGE) Navigator
NCEH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCEH1
genes like me logo Genes that share disorders with NCEH1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCEH1 Gene

Publications for NCEH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression. (PMID: 25280398) Wang J.M. … Ji Z.L. (Mol. Cell. Biochem. 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67

Products for NCEH1 Gene

Sources for NCEH1 Gene

Back to Top

Content