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Aliases for NCDN Gene

Aliases for NCDN Gene

  • Neurochondrin 2 3
  • KIAA0607 4 6

External Ids for NCDN Gene

Previous GeneCards Identifiers for NCDN Gene

  • GC01P035844
  • GC01P035080
  • GC01P035449
  • GC01P035451
  • GC01P035692
  • GC01P035795
  • GC01P036023
  • GC01P034141

Summaries for NCDN Gene

Entrez Gene Summary for NCDN Gene

  • This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCDN Gene

NCDN (Neurochondrin) is a Protein Coding gene. Diseases associated with NCDN include osteochondrosis.

UniProtKB/Swiss-Prot for NCDN Gene

  • Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

Gene Wiki entry for NCDN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCDN Gene

Genomics for NCDN Gene

Regulatory Elements for NCDN Gene

Genomic Location for NCDN Gene

Start:
35,557,473 bp from pter
End:
35,567,274 bp from pter
Size:
9,802 bases
Orientation:
Plus strand

Genomic View for NCDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCDN Gene

Proteins for NCDN Gene

  • Protein details for NCDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBB6-NCDN_HUMAN
    Recommended name:
    Neurochondrin
    Protein Accession:
    Q9UBB6
    Secondary Accessions:
    • D3DPR9
    • Q9UBY2
    • Q9Y4A6
    • Q9Y4D9

    Protein attributes for NCDN Gene

    Size:
    729 amino acids
    Molecular mass:
    78864 Da
    Quaternary structure:
    • Interacts with SEMA4C, DIAPH1 (via FH3 domain) and GRM5 (By similarity). Interacts with MCHR1.
    SequenceCaution:
    • Sequence=AAD05029.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NCDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCDN Gene

Proteomics data for NCDN Gene at MOPED

Post-translational modifications for NCDN Gene

  • Ubiquitination at Lys272
  • Modification sites at PhosphoSitePlus

Other Protein References for NCDN Gene

No data available for DME Specific Peptides for NCDN Gene

Domains for NCDN Gene

Protein Domains for NCDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBB6

UniProtKB/Swiss-Prot:

NCDN_HUMAN :
  • Q9UBB6
Family:
  • Belongs to the neurochondrin family.
genes like me logo Genes that share domains with NCDN: view

No data available for Gene Families for NCDN Gene

Function for NCDN Gene

Molecular function for NCDN Gene

UniProtKB/Swiss-Prot Function: Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for NCDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NCDN: view
genes like me logo Genes that share phenotypes with NCDN: view

miRNA for NCDN Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCDN Gene

Localization for NCDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCDN Gene

Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCDN Gene COMPARTMENTS Subcellular localization image for NCDN gene
Compartment Confidence
cytosol 5
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for NCDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus ISS --
GO:0005829 cytosol ISS --
GO:0016020 membrane IDA 19946888
GO:0030424 NOT axon ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with NCDN: view

Pathways for NCDN Gene

SuperPathways for NCDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development ISS --
GO:0045453 bone resorption IEA --
GO:0048168 regulation of neuronal synaptic plasticity IEA --
genes like me logo Genes that share ontologies with NCDN: view

No data available for Pathways by source for NCDN Gene

Transcripts for NCDN Gene

Unigene Clusters for NCDN Gene

Neurochondrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCDN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for NCDN Gene

GeneLoc Exon Structure for
NCDN
ECgene alternative splicing isoforms for
NCDN

Expression for NCDN Gene

mRNA expression in normal human tissues for NCDN Gene

mRNA differential expression in normal tissues according to GTEx for NCDN Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (9.7), Brain - Putamen (basal ganglia) (6.7), Brain - Caudate (basal ganglia) (6.2), and Brain - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCDN Gene

SOURCE GeneReport for Unigene cluster for NCDN Gene Hs.121870

mRNA Expression by UniProt/SwissProt for NCDN Gene

Q9UBB6-NCDN_HUMAN
Tissue specificity: Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
genes like me logo Genes that share expressions with NCDN: view

Orthologs for NCDN Gene

This gene was present in the common ancestor of animals.

Orthologs for NCDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCDN 35
  • 99.77 (n)
  • 100 (a)
NCDN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCDN 35
  • 92.59 (n)
  • 97.81 (a)
NCDN 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCDN 35
  • 91.68 (n)
  • 97.81 (a)
NCDN 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncdn 35
  • 90.76 (n)
  • 98.22 (a)
Ncdn 16
Ncdn 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCDN 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCDN 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncdn 35
  • 90.67 (n)
  • 97.94 (a)
chicken
(Gallus gallus)
Aves NCDN 35
  • 64.36 (n)
  • 61.91 (a)
NCDN 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCDN 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncdn 35
  • 55.21 (n)
  • 50.14 (a)
zebrafish
(Danio rerio)
Actinopterygii ncdn 35
  • 50.27 (n)
  • 40.26 (a)
ncdn 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013338 35
  • 47.48 (n)
  • 31.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Neurochondrin 35
  • 47.21 (n)
  • 32.01 (a)
Neurochondrin 36
  • 27 (a)
OneToOne
Species with no ortholog for NCDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCDN Gene

ENSEMBL:
Gene Tree for NCDN (if available)
TreeFam:
Gene Tree for NCDN (if available)

Paralogs for NCDN Gene

No data available for Paralogs for NCDN Gene

Variants for NCDN Gene

Sequence variations from dbSNP and Humsavar for NCDN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1140730 -- 35,563,412(+) ACCGC(A/T)CCAGG reference, synonymous-codon
rs1140731 -- 35,563,415(+) GCACC(A/G)GGGCT synonymous-codon, reference
rs2074676 -- 35,562,110(-) TGAGG(C/T)TCCAG intron-variant
rs2074678 -- 35,562,934(-) TGTTA(G/T)ATTTA intron-variant
rs2074679 -- 35,561,487(-) TGGTA(C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCDN Gene

Variant ID Type Subtype PubMed ID
nsv870679 CNV Loss 21882294

Relevant External Links for NCDN Gene

HapMap Linkage Disequilibrium report
NCDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCDN Gene

Disorders for NCDN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NCDN Gene including...

Search for NCDN Gene in MalaCards »

(1) University of Copenhagen DISEASES for NCDN Gene

genes like me logo Genes that share disorders with NCDN: view

No data available for UniProtKB/Swiss-Prot for NCDN Gene

Publications for NCDN Gene

  1. Molecular cloning and expression of human neurochondrin-1 and -2. (PMID: 10524216) Mochizuki R. … Fukamizu A. (Biochim. Biophys. Acta 1999) 3 4 23
  2. Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization. (PMID: 16945926) Francke F. … Baechner D. (J. Biol. Chem. 2006) 4 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1). (PMID: 10684983) Mochizuki R. … Fukamizu A. (Biochim. Biophys. Acta 2000) 3 4
  5. Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75. (PMID: 11162505) Ohoka Y. … Inagaki S. (Biochem. Biophys. Res. Commun. 2001) 3

Products for NCDN Gene

Sources for NCDN Gene

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