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NCDN Gene

protein-coding   GIFtS: 52
GCID: GC01P036023

Neurochondrin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
neurochondrin1 2
KIAA06073 5

External Ids:    HGNC: 175971   Entrez Gene: 231542   Ensembl: ENSG000000201297   OMIM: 6084585   UniProtKB: Q9UBB63   

Export aliases for NCDN gene to outside databases

Previous GC identifers: GC01P035844 GC01P035080 GC01P035449 GC01P035451 GC01P035692 GC01P035795 GC01P034141


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCDN Gene:
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively
regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning
processes. Several alternatively spliced transcript variants of this gene have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NCDN Gene:
NCDN (neurochondrin) is a protein-coding gene. Diseases associated with NCDN include osteochondrosis, and breast and colorectal cancer.

UniProtKB/Swiss-Prot: NCDN_HUMAN, Q9UBB6
Function: Probably involved in signal transduction, in the nervous system, via increasing cell surface
localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning
process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation.
May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1
that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be
involved in neurite outgrowth

Gene Wiki entry for NCDN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCDN gene promoter:
         Brachyury   CUTL1   E4BP4   GATA-2   MZF-1   HEN1   AREB6   Ik-2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCDN promoter sequence
   Search Chromatin IP Primers for NCDN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

NCDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCDN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036023:  view genomic region     (about GC identifiers)

Start:
36,023,074 bp from pter      End:
36,032,875 bp from pter
Size:
9,802 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCDN_HUMAN, Q9UBB6 (See protein sequence)
Recommended Name: Neurochondrin  
Size: 729 amino acids; 78864 Da
Subunit: Interacts with SEMA4C, DIAPH1 (via FH3 domain) and GRM5 (By similarity). Interacts with MCHR1
Sequence caution: Sequence=AAD05029.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DPR9 Q9UBY2 Q9Y4A6 Q9Y4D9
Alternative splicing: 3 isoforms:  Q9UBB6-1   Q9UBB6-2   Q9UBB6-3   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCDN: NX_Q9UBB6

Explore proteomics data for NCDN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys272
  • Modification sites at PhosphoSitePlus

  • See NCDN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001014839.1  NP_001014841.1  NP_055099.1  

    ENSEMBL proteins: 
     ENSP00000362350   ENSP00000348394   ENSP00000362340   ENSP00000406511   ENSP00000407339  

    NCDN Human Recombinant Protein Products:

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    Novus Biologicals NCDN Proteins
    Novus Biologicals NCDN Lysate
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    Cloud-Clone Corp. Proteins for NCDN

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008709 Neurochondrin
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UBB6

    ProtoNet protein and cluster: Q9UBB6

    UniProtKB/Swiss-Prot: NCDN_HUMAN, Q9UBB6
    Similarity: Belongs to the neurochondrin family


    NCDN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCDN_HUMAN, Q9UBB6
    Function: Probably involved in signal transduction, in the nervous system, via increasing cell surface
    localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning
    process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation.
    May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1
    that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be
    involved in neurite outgrowth

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NCDN for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ncdn):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  mortality/aging  nervous system 
     skeleton  vision/eye 

    NCDN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCDN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCDN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCDN

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCDN:
    hsa-mir-421 (MIRT039427), hsa-mir-122-5p (MIRT023258), hsa-mir-18a-3p (MIRT040919), hsa-mir-92a-3p (MIRT049742)

    Block miRNA regulation of human, mouse, rat NCDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCDN (see all 46):
    hsa-miR-3678-3p hsa-miR-596 hsa-miR-3194-5p hsa-miR-631 hsa-miR-1914* hsa-miR-632 hsa-miR-346 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidNCDN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NCDN

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    GenScript: all cDNA clones in your preferred vector (see all 3): NCDN (NM_001014839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCDN

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NCDN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCDN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCDN_HUMAN, Q9UBB6: Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane3
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus ISS--
    GO:0005829cytosol ISS--
    GO:0030424NOT axon ISS--
    GO:0030425dendrite ISS--
    GO:0043005neuron projection ----

    NCDN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCDN
    Interactions:

        Search GeneGlobe Interaction Network for NCDN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for NCDN (Q9UBB63 ENSP000003483944) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    SEMA4CQ9C0C43, ENSP000003068444I2D: score=1 STRING: ENSP00000306844
    LYSTQ996983, ENSP000003744434I2D: score=3 STRING: ENSP00000374443
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031175neuron projection development ISS--
    GO:0045453bone resorption IEA--
    GO:0048168regulation of neuronal synaptic plasticity IEA--

    NCDN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCDN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NCDN gene (3 alternative transcripts): 
    NM_001014839.1  NM_001014841.1  NM_014284.2  

    Unigene Cluster for NCDN:

    Neurochondrin
    Hs.121870  [show with all ESTs]
    Unigene Representative Sequence: BC024592
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373253 ENST00000356090(uc001bza.3 uc001bzc.3) ENST00000373243(uc001bzb.3)
    ENST00000459931 ENST00000437806 ENST00000423723
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NCDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCDN (see all 46):
    hsa-miR-3678-3p hsa-miR-596 hsa-miR-3194-5p hsa-miR-631 hsa-miR-1914* hsa-miR-632 hsa-miR-346 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidNCDN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NCDN
    Predesigned siRNA for gene silencing in human, mouse, rat NCDN
    Clone
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    OriGene ORF clones in mouse, rat for NCDN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NCDN (NM_001014839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCDN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NCDN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCDN
      QuantiTect SYBR Green Assays in human, mouse, rat NCDN
      QuantiFast Probe-based Assays in human, mouse, rat NCDN

    Additional mRNA sequence: 

    AB011179.1 AB018739.2 AB018740.2 AK293658.1 AK295979.1 BC024592.1 

    15 DOTS entries:

    DT.100777596  DT.414291  DT.97809854  DT.95076495  DT.97846756  DT.40124875  DT.100009556  DT.91764860 
    DT.100777595  DT.121377828  DT.40118600  DT.40118601  DT.95223221  DT.121001424  DT.95185397 

    Selected AceView cDNA sequences (see all 158):

    AL133988 BC024592 T09146 BQ063887 BQ723024 AW467935 AA653569 BG056108 
    NM_014284 BU191849 AL043798 BQ889558 BM802213 BM905810 BQ070487 BX113931 
    BM557346 BU157716 BQ671561 AI216097 AL135626 BQ071735 BU162687 BQ672433 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NCDN    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:              -           -     -                                                   
    SP2:              -     -     -     -                                                   
    SP3:                          -     -                                                   
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NCDN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCDN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACACTCA
    NCDN Expression
    About this image


    NCDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Cerebral Cortex
             Subthalamic Nucleus   
     
     Neural Tube (Nervous System)
             Telencephalon
    NCDN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCDN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121870

    UniProtKB/Swiss-Prot: NCDN_HUMAN, Q9UBB6
    Tissue specificity: Abundantly expressed in whole adult brain and in all individual brain regions examined,
    including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NCDN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncdn1 , 5 neurochondrin1, 5 90.76(n)1
    98.22(a)1
      4 (60.93 cM)5
    265621  NM_011986.41  NP_036116.31 
     1267437505 
    chicken
    (Gallus gallus)
    Aves NCDN1 neurochondrin 64.36(n)
    61.91(a)
      419633  NM_001030901.1  NP_001026072.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCDN6
    neurochondrin
    58(a)
    1 ↔ 1
    GL343308.1(6672-23566)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ncdn1 neurochondrin 55.21(n)
    50.14(a)
      100494451  XM_002938833.2  XP_002938879.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncdn1 neurochondrin 50.27(n)
    40.26(a)
      571005  XM_002667083.2  XP_002667129.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Neurochondrin1 Neurochondrin 47.21(n)
    32.01(a)
      40796  NM_141401.1  NP_649658.1 


    ENSEMBL Gene Tree for NCDN (if available)
    TreeFam Gene Tree for NCDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCDN (see all 179)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0398504
    A colorectal cancer sample4--see VAR_0398502 V L mis40--------
    VAR_0398494
    A colorectal cancer sample4--see VAR_0398492 V E mis40--------
    rs1902344071,2
    --36025063(+) CTAGGG/TGCTGC 3 -- int10--------
    rs1512703491,2
    --36025085(+) TTCTGC/GGGCGT 3 -- int10--------
    rs1932588781,2
    --36025088(+) TGGGGC/TGTCCC 3 -- int10--------
    rs1843449281,2
    --36025165(+) GCTGGC/GGATGG 3 -- int10--------
    rs1140628991,2
    F--36025199(+) GCAGGG/CCTGGA 3 -- int11Minor allele frequency- C:0.05WA 118
    rs1417214311,2
    --36025347(+) GGGGG-/TTG   
       TGTGT
    GGGGG
    3 -- int10--------
    rs1142745311,2
    F--36025551(+) GACTTC/TTCTGG 3 -- int11Minor allele frequency- T:0.01NA 120
    rs1163782741,2
    --36025595(+) GGAGAC/TCTTAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for NCDN (36023074 - 36032875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NCDN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870679CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCDN
    DNA2.0 Custom Variant and Variant Library Synthesis for NCDN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608458    OMIM disorders: --

    6 diseases for NCDN:    
    About MalaCards
    osteochondrosis    breast and colorectal cancer    alzheimer's disease    neuronitis
    cerebritis    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for NCDN:
    Osteochondrosis

    NCDN for disorders           About GeneDecksing


    Export disorders for NCDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCDN gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NCDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human neurochondrin-1 and -2. (PubMed id 10524216)1, 2, 9 Mochizuki R....Fukamizu A. (Biochim. Biophys. Acta 1999)
    2. Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1). (PubMed id 10684983)1, 2 Mochizuki R....Fukamizu A. (Biochim. Biophys. Acta 2000)
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    4. Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization. (PubMed id 16945926)2, 9 Francke F.... Baechner D. (J. Biol. Chem. 2006)
    5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    6. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. (PubMed id 23687301)1 Oku S....Fukata M. (J. Biol. Chem. 2013)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23154 HGNC: 17597 AceView: NCDN Ensembl:ENSG00000020129 euGenes: HUgn23154
    ECgene: NCDN H-InvDB: NCDN

    (According to HUGE)
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    HUGE: KIAA0607

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCDN gene:
    Search GeneIP for patents involving NCDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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