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Aliases for NCCRP1 Gene

Aliases for NCCRP1 Gene

  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish) 2 3 5
  • NCC Receptor Protein 1 Homolog 3 4
  • NCCRP-1 3 4
  • FBXO50 3 4
  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog 4
  • Nonspecific Cytotoxic Cell Receptor Protein 1 Homolog 3
  • F-Box Only Protein 50 3

External Ids for NCCRP1 Gene

Previous GeneCards Identifiers for NCCRP1 Gene

  • GC19P044380
  • GC19P039687
  • GC19P036134

Summaries for NCCRP1 Gene

GeneCards Summary for NCCRP1 Gene

NCCRP1 (Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish)) is a Protein Coding gene. An important paralog of this gene is FBXO2.

UniProtKB/Swiss-Prot for NCCRP1 Gene

  • Promotes cell proliferation.

Additional gene information for NCCRP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCCRP1 Gene

Genomics for NCCRP1 Gene

Regulatory Elements for NCCRP1 Gene

Enhancers for NCCRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039166 1.4 Ensembl ENCODE dbSUPER 13.5 -28.8 -28777 3.5 PKNOX1 NFIB SIN3A ZBTB7B ZNF121 GLIS2 SCRT2 EGR2 SP5 ZIK1 PAK4 HNRNPL FBL NCCRP1 SYCN ENSG00000269688 ZNF780B FBXO17 RPS16 ZNF780A
GH19H039198 0.8 ENCODE 8.3 -1.6 -1616 0.3 ZBTB21 CHD4 ZMYM3 ZIC2 ZEB1 ZNF664 PATZ1 ADNP PRDM10 RCOR1 NCCRP1 GC19P039153
GH19H039199 0.7 ENCODE 8.9 +2.8 2795 2.1 TFAP4 PKNOX1 ZNF362 ZNF521 CEBPG ZNF645 ZNF121 ZNF776 ZSCAN16 ZBTB33 ENSG00000266963 ENSG00000269172 ENSG00000269792 LOC105372399 LGALS14 ENSG00000267375 ENSG00000269445 CATSPERG LOC100129935 ZNF780B
GH19H039193 0.7 ENCODE 8.3 -3.0 -3006 0.2 MAZ KLF1 KLF17 SIN3A MNT NR3C1 ZBTB7B ZFHX2 GLIS1 TARDBP NCCRP1 GC19P039153
GH19H039200 0.6 ENCODE 7.7 0.0 -6 0.2 RING1 L3MBTL2 MAX CTBP1 POLR2A ID3 KLF9 EZH2 MGA SUPT5H ZNF780B ZNF780A NCCRP1 GC19P039153
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCCRP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NCCRP1 Gene

Genomic Locations for NCCRP1 Gene
4,924 bases
Plus strand

Genomic View for NCCRP1 Gene

Genes around NCCRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCCRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCCRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCCRP1 Gene

Proteins for NCCRP1 Gene

  • Protein details for NCCRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 50
    Protein Accession:
    Secondary Accessions:
    • Q6NVV5

    Protein attributes for NCCRP1 Gene

    275 amino acids
    Molecular mass:
    30847 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCCRP1 Gene

Post-translational modifications for NCCRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCCRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCCRP1 Gene

Domains & Families for NCCRP1 Gene

Gene Families for NCCRP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCCRP1 Gene

Suggested Antigen Peptide Sequences for NCCRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCCRP1: view

No data available for UniProtKB/Swiss-Prot for NCCRP1 Gene

Function for NCCRP1 Gene

Molecular function for NCCRP1 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Phenotypes for NCCRP1 Gene

genes like me logo Genes that share phenotypes with NCCRP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCCRP1 Gene

Localization for NCCRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCCRP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCCRP1 gene
Compartment Confidence
extracellular 5
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22087255
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NCCRP1: view

Pathways & Interactions for NCCRP1 Gene

SuperPathways for NCCRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 22087255
genes like me logo Genes that share ontologies with NCCRP1: view

No data available for Pathways by source and SIGNOR curated interactions for NCCRP1 Gene

Drugs & Compounds for NCCRP1 Gene

No Compound Related Data Available

Transcripts for NCCRP1 Gene

mRNA/cDNA for NCCRP1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCCRP1 Gene

Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCCRP1 Gene

No ASD Table

Relevant External Links for NCCRP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCCRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCCRP1 Gene

mRNA differential expression in normal tissues according to GTEx for NCCRP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.1), Skin - Sun Exposed (Lower leg) (x11.2), Skin - Not Sun Exposed (Suprapubic) (x8.5), Vagina (x6.6), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for NCCRP1 Gene

This gene is overexpressed in Cervix (39.5) and Saliva (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCCRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCCRP1 Gene:


SOURCE GeneReport for Unigene cluster for NCCRP1 Gene:


mRNA Expression by UniProt/SwissProt for NCCRP1 Gene:

Tissue specificity: Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.

Evidence on tissue expression from TISSUES for NCCRP1 Gene

  • Kidney(2.1)
genes like me logo Genes that share expression patterns with NCCRP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCCRP1 Gene

Orthologs for NCCRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCCRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCCRP1 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia NCCRP1 33 34
  • 86.92 (n)
(Bos Taurus)
Mammalia NCCRP1 33 34
  • 84.74 (n)
(Rattus norvegicus)
Mammalia Nccrp1 33
  • 79.57 (n)
(Mus musculus)
Mammalia Nccrp1 33 16 34
  • 78.7 (n)
(Monodelphis domestica)
Mammalia NCCRP1 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia NCCRP1 34
  • 50 (a)
(Anolis carolinensis)
Reptilia NCCRP1 34
  • 47 (a)
(Danio rerio)
Actinopterygii nccrp1 34
  • 39 (a)
Species where no ortholog for NCCRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCCRP1 Gene

Gene Tree for NCCRP1 (if available)
Gene Tree for NCCRP1 (if available)

Paralogs for NCCRP1 Gene

Paralogs for NCCRP1 Gene

genes like me logo Genes that share paralogs with NCCRP1: view

Variants for NCCRP1 Gene

Sequence variations from dbSNP and Humsavar for NCCRP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000471949 -- 39,196,368(+) GAGTG(A/G)GGAGG upstream-variant-2KB
rs1000754098 -- 39,197,814(+) TGGCC(G/T)GTCTC intron-variant
rs1000823063 -- 39,196,564(+) GGAGG(A/G)GGCTG upstream-variant-2KB
rs1001197160 -- 39,195,802(+) CGGGA(A/G)GCGGA upstream-variant-2KB
rs1001207343 -- 39,197,547(+) CTCTC(C/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCCRP1 Gene

Variant ID Type Subtype PubMed ID
nsv953571 CNV deletion 24416366
nsv833829 CNV loss 17160897
esv3644325 CNV loss 21293372
esv2718550 CNV deletion 23290073
esv2658631 CNV deletion 23128226

Variation tolerance for NCCRP1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCCRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCCRP1 Gene

Disorders for NCCRP1 Gene

Relevant External Links for NCCRP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NCCRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCCRP1 Gene

Publications for NCCRP1 Gene

  1. Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. (PMID: 22087255) Kallio H … Parkkila S (PloS one 2011) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan JT … Howley PM (Journal of proteome research 2015) 3 60
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for NCCRP1 Gene

Sources for NCCRP1 Gene

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