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NCCRP1 Gene

protein-coding   GIFtS: 38
GCID: GC19P039687

Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish)

  Search for NCCRP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish)1 2     F-Box Only Protein 502
FBXO502 3     Nonspecific Cytotoxic Cell Receptor Protein 1 Homolog2
NCCRP-12 3     Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog3
NCC Receptor Protein 1 Homolog2 3     

External Ids:    HGNC: 337391   Entrez Gene: 3428972   Ensembl: ENSG000001885057   UniProtKB: Q6ZVX73   

Export aliases for NCCRP1 gene to outside databases

Previous GC identifers: GC19P044380 GC19P036134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NCCRP1 Gene:
NCCRP1 (non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)) is a protein-coding gene. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot: FBX50_HUMAN, Q6ZVX7
Function: Promotes cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NCCRP1 gene promoter:
         CREB   NRSF form 1   RelA   NF-kappaB1   NF-kappaB   NRSF form 2   GATA-1   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NCCRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCCRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

NCCRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCCRP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039687:  view genomic region     (about GC identifiers)

Start:
39,687,601 bp from pter      End:
39,692,524 bp from pter
Size:
4,924 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX50_HUMAN, Q6ZVX7 (See protein sequence)
Recommended Name: F-box only protein 50  
Size: 275 amino acids; 30847 Da
Secondary accessions: Q6NVV5

Explore the universe of human proteins at neXtProt for NCCRP1: NX_Q6ZVX7

Explore proteomics data for NCCRP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NCCRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001414.1  
    ENSEMBL proteins: 
     ENSP00000342137  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007397 F-box-assoc_dom
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q6ZVX7

    ProtoNet protein and cluster: Q6ZVX7

    1 Blocks protein domain: IPB007397 F-box associated region

    UniProtKB/Swiss-Prot: FBX50_HUMAN, Q6ZVX7
    Similarity: Contains 1 FBA (F-box associated) domain


    Find genes that share domains with NCCRP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX50_HUMAN, Q6ZVX7
    Function: Promotes cell proliferation

    Animal Models:

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    hsa-miR-383 hsa-miR-4257
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX50_HUMAN, Q6ZVX7: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with NCCRP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCCRP1
    Interactions:

        Search GeneGlobe Interaction Network for NCCRP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for NCCRP1 (Q6ZVX73 ENSP000003421374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    GOSR1O952493I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA--
    GO:0030163protein catabolic process IEA--

    Find genes that share ontologies with NCCRP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCCRP1 (FBX50)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCCRP1 gene: 
    NM_001001414.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339852(uc002okq.1)
    miRNA
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    hsa-miR-383 hsa-miR-4257
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NCCRP1
      QuantiFast Probe-based Assays in human, mouse, rat NCCRP1

    13 AceView cDNA sequences:

    AK123941 NM_001001414 BF939202 CB997998 AW268509 BM982371 BC067874 BG741204 
    BF367768 N42313 CB994682 BF832796 BE714878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCCRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGTGGTGA
    NCCRP1 Expression
    About this image

    NCCRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCCRP1 Protein Expression

    UniProtKB/Swiss-Prot: FBX50_HUMAN, Q6ZVX7
    Tissue specificity: Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCCRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCCRP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nccrp11 , 5 non-specific cytotoxic cell receptor protein 1 homolog more1, 5 78.7(n)1
    75.94(a)1
      7 (16.83 cM)5
    2330381  NM_001081115.11  NP_001074584.11 
     285435965 
    lizard
    (Anolis carolinensis)
    Reptilia NCCRP16
    non-specific cytotoxic cell receptor protein 1 hom...
    47(a)
    1 ↔ 1
    GL343755.1(99588-111947)
    zebrafish
    (Danio rerio)
    Actinopterygii nccrp16
    nonspecific cytotoxic cell receptor protein 1
    39(a)
    1 ↔ 1
    5(38450813-38454718) ENSDARG00000035326


    ENSEMBL Gene Tree for NCCRP1 (if available)
    TreeFam Gene Tree for NCCRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCCRP1 gene
    FBXO172  FBXO62  FBXO272  FBXO22  FBXO442  

    Find genes that share paralogs with NCCRP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCCRP1 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23191551,2
    C,F,A,H--39685635(+) CCACAC/TTCAGC 1 -- us2k110Minor allele frequency- T:0.33NA WA CSA EA 374
    rs786952631,2
    C,F--39685641(+) TCAGCC/TCTTGG 1 -- us2k11Minor allele frequency- T:0.18WA 118
    rs81006591,2
    C,F,A,H--39685712(+) AACTCG/TTTGTG 1 -- us2k117Minor allele frequency- N:0.00NS EA NA WA CSA 996
    rs1482786941,2
    C--39685721(+) TGTACC/TAGCTG 1 -- us2k10--------
    rs800826831,2
    C,F--39685844(+) TTGCCT/CAATTA 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs81032221,2
    C,F,A,H--39685869(+) TTGCAA/CCTAAT 1 -- us2k18Minor allele frequency- C:0.34NA WA EA 370
    rs81032241,2
    C,F,A,H--39685873(+) AACTAA/GTGGAC 1 -- us2k18Minor allele frequency- G:0.34NA WA EA 370
    rs1909890601,2
    C--39686386(+) CACATA/GCCTGT 1 -- us2k10--------
    rs1833059541,2
    --39686471(+) TCGTGC/TTTCTG 1 -- us2k10--------
    rs1505917481,2
    C--39686510(+) CCATC-/AGAGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCCRP1 (39687601 - 39692524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NCCRP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658631CNV Deletion23128226
    esv2718550CNV Deletion23290073
    nsv833829CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCCRP1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NCCRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. (PubMed id 22087255)1, 2 Kallio H.... Parkkila S. (PLoS ONE 2011)
    2. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (Proteomics 2011)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342897 HGNC: 33739 AceView: LOC342897 Ensembl:ENSG00000188505 euGenes: HUgn342897
    ECgene: NCCRP1 H-InvDB: NCCRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCCRP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCCRP1 gene:
    Search GeneIP for patents involving NCCRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for NCCRP1 Search Chromatin IP Primers for NCCRP1
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     Search Addgene for plasmids for NCCRP1
      Search eBioscience for proteins for NCCRP1
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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