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Aliases for NCCRP1 Gene

Aliases for NCCRP1 Gene

  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish) 2 3
  • NCC Receptor Protein 1 Homolog 3 4
  • NCCRP-1 3 4
  • FBXO50 3 4
  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog 4
  • Nonspecific Cytotoxic Cell Receptor Protein 1 Homolog 3
  • F-Box Only Protein 50 3

External Ids for NCCRP1 Gene

Summaries for NCCRP1 Gene

GeneCards Summary for NCCRP1 Gene

NCCRP1 (Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish)) is a Protein Coding gene. An important paralog of this gene is FBXO27.

UniProtKB/Swiss-Prot for NCCRP1 Gene

  • Promotes cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCCRP1 Gene

Genomics for NCCRP1 Gene

Genomic Location for NCCRP1 Gene

Start:
39,196,961 bp from pter
End:
39,201,884 bp from pter
Size:
4,924 bases
Orientation:
Plus strand

Genomic View for NCCRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCCRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCCRP1 Gene

Regulatory Elements for NCCRP1 Gene

Proteins for NCCRP1 Gene

  • Protein details for NCCRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVX7-FBX50_HUMAN
    Recommended name:
    F-box only protein 50
    Protein Accession:
    Q6ZVX7
    Secondary Accessions:
    • Q6NVV5

    Protein attributes for NCCRP1 Gene

    Size:
    275 amino acids
    Molecular mass:
    30847 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCCRP1 Gene

Proteomics data for NCCRP1 Gene at MOPED

Post-translational modifications for NCCRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCCRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCCRP1 Gene

Domains for NCCRP1 Gene

Protein Domains for NCCRP1 Gene

UniProtKB/Swiss-Prot:

FBX50_HUMAN
Domain:
  • Contains 1 FBA (F-box associated) domain.:
    • Q6ZVX7
genes like me logo Genes that share domains with NCCRP1: view

No data available for Gene Families for NCCRP1 Gene

Function for NCCRP1 Gene

Molecular function for NCCRP1 Gene

UniProtKB/Swiss-Prot Function: Promotes cell proliferation.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCCRP1 Gene

Localization for NCCRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCCRP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCCRP1 Gene COMPARTMENTS Subcellular localization image for NCCRP1 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22087255
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NCCRP1: view

Pathways for NCCRP1 Gene

SuperPathways for NCCRP1 Gene

No Data Available

Interacting Proteins for NCCRP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342137%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000342137 Q6ZVX7-FBX50_HUMAN for NCCRP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 22087255
genes like me logo Genes that share ontologies with NCCRP1: view

No data available for Pathways by source for NCCRP1 Gene

Transcripts for NCCRP1 Gene

mRNA/cDNA for NCCRP1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCCRP1 Gene

Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCCRP1 Gene

No ASD Table

Relevant External Links for NCCRP1 Gene

GeneLoc Exon Structure for
NCCRP1
ECgene alternative splicing isoforms for
NCCRP1

Expression for NCCRP1 Gene

mRNA expression in normal human tissues for NCCRP1 Gene

mRNA differential expression in normal tissues according to GTEx for NCCRP1 Gene

This gene is overexpressed in Esophagus - Mucosa (19.1), Skin - Sun Exposed (Lower leg) (11.2), Skin - Not Sun Exposed (Suprapubic) (8.5), Vagina (6.6), and Cervix - Ectocervix (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NCCRP1 Gene

SOURCE GeneReport for Unigene cluster for NCCRP1 Gene Hs.726934

mRNA Expression by UniProt/SwissProt for NCCRP1 Gene

Q6ZVX7-FBX50_HUMAN
Tissue specificity: Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.
genes like me logo Genes that share expressions with NCCRP1: view

Orthologs for NCCRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCCRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCCRP1 36
  • 99.52 (n)
  • 99.64 (a)
NCCRP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCCRP1 36
  • 84.74 (n)
  • 85.38 (a)
NCCRP1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCCRP1 36
  • 86.92 (n)
  • 82.64 (a)
NCCRP1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nccrp1 36
  • 78.7 (n)
  • 75.94 (a)
Nccrp1 16
Nccrp1 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCCRP1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCCRP1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nccrp1 36
  • 79.57 (n)
  • 77.07 (a)
lizard
(Anolis carolinensis)
Reptilia NCCRP1 37
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nccrp1 37
  • 39 (a)
OneToOne
Species with no ortholog for NCCRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCCRP1 Gene

ENSEMBL:
Gene Tree for NCCRP1 (if available)
TreeFam:
Gene Tree for NCCRP1 (if available)

Paralogs for NCCRP1 Gene

Paralogs for NCCRP1 Gene

genes like me logo Genes that share paralogs with NCCRP1: view

Variants for NCCRP1 Gene

Sequence variations from dbSNP and Humsavar for NCCRP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs867348 -- 39,196,481(-) GTGAC(A/T)AATGT upstream-variant-2KB
rs867349 -- 39,196,261(-) CCCTG(A/C)CACAT upstream-variant-2KB
rs2319155 -- 39,194,995(+) CCACA(C/T)TCAGC upstream-variant-2KB
rs2319156 -- 39,196,035(+) GCCCC(A/G)TCCCT upstream-variant-2KB
rs3057082 -- 39,195,871(+) AGAGA(-/GA)AGCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCCRP1 Gene

Variant ID Type Subtype PubMed ID
nsv833829 CNV Loss 17160897
esv2718550 CNV Deletion 23290073
esv2658631 CNV Deletion 23128226

Relevant External Links for NCCRP1 Gene

HapMap Linkage Disequilibrium report
NCCRP1

Disorders for NCCRP1 Gene

No disorders were found for NCCRP1 Gene.

No data available for UniProtKB/Swiss-Prot for NCCRP1 Gene

Publications for NCCRP1 Gene

  1. Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. (PMID: 22087255) Kallio H. … Parkkila S. (PLoS ONE 2011) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NCCRP1 Gene

Sources for NCCRP1 Gene

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