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Aliases for NCBP3 Gene

Aliases for NCBP3 Gene

  • Nuclear Cap Binding Subunit 3 2 3 5
  • C17orf85 3 4
  • Chromosome 17 Open Reading Frame 85 2
  • CTD-3195I5.1 3
  • CTD-3195I5.5 3
  • ELG Protein 2
  • Protein ELG 4
  • HSA277841 3
  • ELG 3

External Ids for NCBP3 Gene

Previous HGNC Symbols for NCBP3 Gene

  • C17orf85

Summaries for NCBP3 Gene

GeneCards Summary for NCBP3 Gene

NCBP3 (Nuclear Cap Binding Subunit 3) is a Protein Coding gene. Diseases associated with NCBP3 include Vertebral Artery Insufficiency.

UniProtKB/Swiss-Prot for NCBP3 Gene

  • Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCBP3 Gene

Genomics for NCBP3 Gene

Regulatory Elements for NCBP3 Gene

Enhancers for NCBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCBP3 on UCSC Golden Path with GeneCards custom track

Promoters for NCBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCBP3 Gene

Chromosome:
17
Start:
3,802,160 bp from pter
End:
3,846,251 bp from pter
Size:
44,092 bases
Orientation:
Minus strand

Genomic View for NCBP3 Gene

Genes around NCBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCBP3 Gene

Proteins for NCBP3 Gene

  • Protein details for NCBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53F19-NCBP3_HUMAN
    Recommended name:
    Nuclear cap-binding protein subunit 3
    Protein Accession:
    Q53F19
    Secondary Accessions:
    • B3KWG7
    • Q7L406
    • Q96FK1
    • Q9NXZ4

    Protein attributes for NCBP3 Gene

    Size:
    620 amino acids
    Molecular mass:
    70593 Da
    Quaternary structure:
    • Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3. Interacts with SRRT, KPNA3, THOC5 and EIF4A3.
    SequenceCaution:
    • Sequence=BAD97190.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCBP3 Gene

Proteomics data for NCBP3 Gene at MOPED

Post-translational modifications for NCBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCBP3 Gene

Domains & Families for NCBP3 Gene

Protein Domains for NCBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53F19

UniProtKB/Swiss-Prot:

NCBP3_HUMAN :
  • Belongs to the NCBP3 family.
Family:
  • Belongs to the NCBP3 family.
genes like me logo Genes that share domains with NCBP3: view

No data available for Gene Families for NCBP3 Gene

Function for NCBP3 Gene

Molecular function for NCBP3 Gene

UniProtKB/Swiss-Prot Function:
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).

Gene Ontology (GO) - Molecular Function for NCBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000340 RNA 7-methylguanosine cap binding IMP 26382858
GO:0003729 mRNA binding IDA 26382858
genes like me logo Genes that share ontologies with NCBP3: view
genes like me logo Genes that share phenotypes with NCBP3: view

Animal Model Products

miRNA for NCBP3 Gene

miRTarBase miRNAs that target NCBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCBP3 Gene

Localization for NCBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCBP3 Gene

Nucleus. Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NCBP3 Gene

Pathways & Interactions for NCBP3 Gene

SuperPathways for NCBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCBP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NCBP3 Gene

Drugs & Compounds for NCBP3 Gene

No Compound Related Data Available

Transcripts for NCBP3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NCBP3 Gene

No ASD Table

Relevant External Links for NCBP3 Gene

GeneLoc Exon Structure for
NCBP3
ECgene alternative splicing isoforms for
NCBP3

Expression for NCBP3 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NCBP3 Gene

Orthologs for NCBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C19H17orf85 35
  • 90.94 (n)
  • 94.46 (a)
C17orf85 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf85 35
  • 92.4 (n)
  • 93.97 (a)
C17orf85 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1200014J11Rik 35
  • 89.63 (n)
  • 94.84 (a)
Ncbp3 16
1200014J11Rik 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf85 35
  • 99.5 (n)
  • 99.83 (a)
C17orf85 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308139 35
  • 88.13 (n)
  • 94.01 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf85 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19H17ORF85 35
  • 76.73 (n)
  • 82.94 (a)
C19H17ORF85 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c17orf85 35
  • 68.63 (n)
  • 71.58 (a)
Str.1399 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33463 35
zebrafish
(Danio rerio)
Actinopterygii zgc55870 35
zgc:55870 35
  • 63.87 (n)
  • 64.03 (a)
C21H17orf85 36
  • 55 (a)
OneToOne
Species with no ortholog for NCBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCBP3 Gene

ENSEMBL:
Gene Tree for NCBP3 (if available)
TreeFam:
Gene Tree for NCBP3 (if available)

Paralogs for NCBP3 Gene

No data available for Paralogs for NCBP3 Gene

Variants for NCBP3 Gene

Sequence variations from dbSNP and Humsavar for NCBP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11469 -- 3,807,536(-) GTAAA(A/T)GAATG intron-variant, utr-variant-3-prime
rs170150 -- 3,831,782(-) atctt(A/G)ttctt intron-variant
rs170151 -- 3,827,239(-) AGTTT(A/T)AATAT intron-variant, upstream-variant-2KB
rs172645 -- 3,844,588(-) caggc(C/G)tgagc intron-variant
rs177986 -- 3,831,400(-) agaga(C/T)ggggt intron-variant

Variation tolerance for NCBP3 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NCBP3 Gene

Disorders for NCBP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCBP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vertebral artery insufficiency
  • vertebral artery syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NCBP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCBP3
genes like me logo Genes that share disorders with NCBP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCBP3 Gene

Publications for NCBP3 Gene

  1. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. (PMID: 26382858) Gebhardt A. … Pichlmair A. (Nat Commun 2015) 2 3 4 67
  2. Studies on transcriptional regulation of the mucosal T-cell integrin alphaEbeta7 (CD103). (PMID: 11412301) Robinson P.W. … Kilshaw P.J. (Immunology 2001) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NCBP3 Gene

Sources for NCBP3 Gene

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