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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCBP2L Gene

protein-coding   GIFtS: 25
GCID: GC0XP107037

Nuclear Cap Binding Protein Subunit 2-Like

  Search for NCBP2L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Cap Binding Protein Subunit 2-Like1 2
dJ820B18.12

External Ids:    HGNC: 317951   Entrez Gene: 3925172   Ensembl: ENSG000001709357   UniProtKB: A6PVI33   

Export aliases for NCBP2L gene to outside databases

Previous GC identifers: GC0XP106825 GC0XU900756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NCBP2L Gene: 
NCBP2L (nuclear cap binding protein subunit 2-like) is a protein-coding gene. GO annotations related to this gene include nucleotide binding and nucleic acid binding. An important paralog of this gene is NCBP2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NCBP2L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NCBP2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCBP2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

NCBP2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCBP2L gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP107037:  view genomic region     (about GC identifiers)

Start:
107,037,451 bp from pter      End:
107,037,912 bp from pter
Size:
462 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCB2L_HUMAN, A6PVI3 (See protein sequence)
Recommended Name: Nuclear cap-binding protein subunit 2-like  
Size: 153 amino acids; 17685 Da

Explore the universe of human proteins at neXtProt for NCBP2L: NX_A6PVI3

Explore proteomics data for NCBP2L at MOPED 

NCBP2L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NCBP2L Protein Expression

ENSEMBL proteins: 
 ENSP00000361454  

Human Recombinant Protein Products for NCBP2L: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005846nuclear cap binding complex IEA--

NCBP2L for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RBM: RNA binding motif (RRM) containing

3 InterPro protein domains:
 IPR012677 Nucleotide-bd_a/b_plait
 IPR027157 NCBP2
 IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry A6PVI3

ProtoNet protein and cluster: A6PVI3

UniProtKB/Swiss-Prot: NCB2L_HUMAN, A6PVI3
Similarity: Belongs to the RRM NCBP2 family
Similarity: Contains 1 RRM (RNA recognition motif) domain


NCBP2L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding IEA--
GO:0000339RNA cap binding IEA--
GO:0003676nucleic acid binding ----
     
NCBP2L for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCBP2L

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/24 Interacting proteins for NCBP2L (ENSP000003614544) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
InteractantInteraction Details
GeneCardExternal ID(s)
PRPF8ENSP000003043504STRING: ENSP00000304350
DKC1ENSP000003585634STRING: ENSP00000358563
NAT10ENSP000002578294STRING: ENSP00000257829
SNRPD2ENSP000003423744STRING: ENSP00000342374
KRR1ENSP000002292144STRING: ENSP00000229214
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045292mRNA cis splicing, via spliceosome IEA--

NCBP2L for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for NCBP2L (NCB2L)

Search CenterWatch for drugs/clinical trials and news about NCBP2L / NCB2L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000372379
miRNA
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1 AceView cDNA sequence:

AI209084 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NCBP2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NCBP2L Expression
About this image


See NCBP2L Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for NCBP2L
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCBP2L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCBP2L gene from 7/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia NCBP2L6
nuclear cap binding protein subunit 2-like
66(a)
1 ↔ 1
X(81314455-81314946)
chicken
(Gallus gallus)
Aves NCBP26
--
--
57(a)
57(a)
possible ortholog
1 ↔ many
4(2417943-2420697)
9(11933114-11934882)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
55(a)
possible ortholog
GL343758.1(73652-77886)
zebrafish
(Danio rerio)
Actinopterygii ncbp26
nuclear cap binding protein subunit 2
61(a)
1 → many
22(41975987-41980251)
fruit fly
(Drosophila melanogaster)
Insecta Cbp206
cap binding protein 20
56(a)
1 → many
3R(13990385-13991161)
worm
(Caenorhabditis elegans)
Secernentea ncbp-26
Nuclear cap-binding protein subunit 2
46(a)
1 → many
I(7642427-7643328)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBC26
Small subunit of the heterodimeric cap binding com...
33(a)
1 → many
XVI(212158-212784)


ENSEMBL Gene Tree for NCBP2L (if available)
TreeFam Gene Tree for NCBP2L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NCBP2L gene
NCBP22  
2 SIMAP similar genes for NCBP2L using alignment to 1 protein entry:     NCB2L_HUMAN:
NCBP2    DKFZp686G18222

NCBP2L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): NCBP2L
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing NCBP2L
DNA2.0 Custom Variant and Variant Library Synthesis for NCBP2L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NCBP2L gene integrated from 9 sources:
(articles sorted by number of sources associating them with NCBP2L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 392517 HGNC: 31795 AceView: NCBP2L Ensembl:ENSG00000170935 euGenes: HUgn392517
ECgene: NCBP2L H-InvDB: NCBP2L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NCBP2L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NCBP2L gene:
Search GeneIP for patents involving NCBP2L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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