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Aliases for NCBP1 Gene

Aliases for NCBP1 Gene

  • Nuclear Cap Binding Protein Subunit 1 2 3 5
  • Nuclear Cap Binding Protein Subunit 1, 80kDa 2 3
  • Nuclear Cap Binding Protein Subunit 1, 80kD 2 3
  • 80 KDa Nuclear Cap-Binding Protein 3 4
  • NCBP 80 KDa Subunit 3 4
  • CBP80 3 4
  • NCBP 3 4
  • Sto1 3

External Ids for NCBP1 Gene

Previous HGNC Symbols for NCBP1 Gene

  • NCBP

Previous GeneCards Identifiers for NCBP1 Gene

  • GC09P091221
  • GC09P092139
  • GC09P093853
  • GC09P095775
  • GC09P097475
  • GC09P099435
  • GC09P100395
  • GC09P069996

Summaries for NCBP1 Gene

Entrez Gene Summary for NCBP1 Gene

  • The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCBP1 Gene

NCBP1 (Nuclear Cap Binding Protein Subunit 1) is a Protein Coding gene. Diseases associated with NCBP1 include asthenopia. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for NCBP1 Gene

  • Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5-end of mRNA and to mRNA export in a 5 to 3 direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in failsafe NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCBP1 Gene

Genomics for NCBP1 Gene

Regulatory Elements for NCBP1 Gene

Promoters for NCBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NCBP1 Gene

Chromosome:
9
Start:
97,633,423 bp from pter
End:
97,673,748 bp from pter
Size:
40,326 bases
Orientation:
Plus strand

Genomic View for NCBP1 Gene

Genes around NCBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCBP1 Gene

Proteins for NCBP1 Gene

  • Protein details for NCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09161-NCBP1_HUMAN
    Recommended name:
    Nuclear cap-binding protein subunit 1
    Protein Accession:
    Q09161
    Secondary Accessions:
    • B2R718
    • Q59G76
    • Q5T1V0
    • Q5T7X2

    Protein attributes for NCBP1 Gene

    Size:
    790 amino acids
    Molecular mass:
    91839 Da
    Quaternary structure:
    • Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Found in a U snRNA export complex containing PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PHAX/RNUXA, SRRT/ARS2, EIF4G2, IGF2BP1, HNRNPF, HNRNPH1, KIAA0427/CTIF, PARN, DROSHA, UPF1 and ALYREF/THOC4. May interact with EIF4G1; the interaction is however controversial since it is reported by PubMed:11340157, PubMed:15059963 and PubMed:15361857, but is not observed by PubMed:19648179. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1/CBP80 and POLR2A. Component of an alternative nuclear cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=BAD92470.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI12863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCBP1 Gene

neXtProt entry for NCBP1 Gene

Proteomics data for NCBP1 Gene at MOPED

Post-translational modifications for NCBP1 Gene

  • Ubiquitination at Lys 204 and Lys 323
  • Modification sites at PhosphoSitePlus

Other Protein References for NCBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCBP1 (NCBP1)

No data available for DME Specific Peptides for NCBP1 Gene

Domains & Families for NCBP1 Gene

Suggested Antigen Peptide Sequences for NCBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q09161

UniProtKB/Swiss-Prot:

NCBP1_HUMAN :
  • Contains 1 MIF4G domain.
  • Belongs to the NCBP1 family.
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the NCBP1 family.
genes like me logo Genes that share domains with NCBP1: view

No data available for Gene Families for NCBP1 Gene

Function for NCBP1 Gene

Molecular function for NCBP1 Gene

GENATLAS Biochemistry:
nuclear cap binding protein 1,component of the cap-binding protein complex in association with NCBP2 and other proteins,mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
UniProtKB/Swiss-Prot Function:
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5-end of mRNA and to mRNA export in a 5 to 3 direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in failsafe NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).
genes like me logo Genes that share phenotypes with NCBP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NCBP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCBP1 Gene

Localization for NCBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCBP1 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269 PubMed:17289661}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCBP1 Gene COMPARTMENTS Subcellular localization image for NCBP1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for NCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NCBP1: view

Pathways & Interactions for NCBP1 Gene

SuperPathways for NCBP1 Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Termination
3 Regulation of Glucokinase by Glucokinase Regulatory Protein
4 mRNA Splicing - Major Pathway
5 RNA Polymerase II Transcription Initiation And Promoter Clearance
genes like me logo Genes that share pathways with NCBP1: view

Pathways by source for NCBP1 Gene

Gene Ontology (GO) - Biological Process for NCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with NCBP1: view

No data available for SIGNOR curated interactions for NCBP1 Gene

Drugs & Compounds for NCBP1 Gene

No Compound Related Data Available

Transcripts for NCBP1 Gene

Unigene Clusters for NCBP1 Gene

Nuclear cap binding protein subunit 1, 80kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCBP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: - - - -
SP3: -
SP4:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:

Relevant External Links for NCBP1 Gene

GeneLoc Exon Structure for
NCBP1
ECgene alternative splicing isoforms for
NCBP1

Expression for NCBP1 Gene

mRNA expression in normal human tissues for NCBP1 Gene

Protein differential expression in normal tissues from HIPED for NCBP1 Gene

This gene is overexpressed in Lymph node (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCBP1 Gene



SOURCE GeneReport for Unigene cluster for NCBP1 Gene Hs.595669

genes like me logo Genes that share expression patterns with NCBP1: view

Protein tissue co-expression partners for NCBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCBP1 Gene

Orthologs for NCBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCBP1 35
  • 94.3 (n)
  • 99.11 (a)
NCBP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCBP1 35
  • 94.73 (n)
  • 99.62 (a)
NCBP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncbp1 35
  • 89.54 (n)
  • 97.97 (a)
Ncbp1 16
Ncbp1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCBP1 35
  • 99.83 (n)
  • 100 (a)
NCBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncbp1 35
  • 89.96 (n)
  • 98.1 (a)
oppossum
(Monodelphis domestica)
Mammalia NCBP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCBP1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCBP1 35
  • 80.89 (n)
  • 90.63 (a)
NCBP1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCBP1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncbp1 35
  • 76.75 (n)
  • 84.81 (a)
Str.7354 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2984 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3727 35
zebrafish
(Danio rerio)
Actinopterygii NCBP1 (1 of 2) 36
  • 40 (a)
OneToMany
NCBP1 (2 of 2) 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cbp80 37
  • 56 (a)
CG7907 37
  • 32 (a)
Cbp80 35
  • 56.84 (n)
  • 58.61 (a)
Cbp80 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NCBP1_ANOGA 35
  • 56.96 (n)
  • 56.58 (a)
worm
(Caenorhabditis elegans)
Secernentea F37E3.1 37
  • 33 (a)
ncbp-1 35
  • 48.13 (n)
  • 35.87 (a)
ncbp-1 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STO1 36
  • 16 (a)
OneToOne
STO1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ABH1 35
  • 44.35 (n)
  • 31.27 (a)
rice
(Oryza sativa)
Liliopsida Os03g0347200 35
  • 44.2 (n)
  • 31.28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4448 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3836 36
  • 53 (a)
OneToOne
Species with no ortholog for NCBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCBP1 Gene

ENSEMBL:
Gene Tree for NCBP1 (if available)
TreeFam:
Gene Tree for NCBP1 (if available)

Paralogs for NCBP1 Gene

No data available for Paralogs for NCBP1 Gene

Variants for NCBP1 Gene

Sequence variations from dbSNP and Humsavar for NCBP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2773352 -- 97,652,377(+) atttg(C/G)ggggc intron-variant
rs2026132 -- 97,653,558(-) TTATT(C/T)GATCT intron-variant
rs2805772 -- 97,639,908(-) ACCAA(C/G)CATCT intron-variant
rs3763606 -- 97,643,183(+) CTTGT(G/T)ATACT intron-variant
rs3802474 -- 97,647,821(+) AATGT(A/C)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv893610 CNV Gain 21882294

Variation tolerance for NCBP1 Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCBP1 Gene

HapMap Linkage Disequilibrium report
NCBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCBP1 Gene

Disorders for NCBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCBP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
asthenopia
  • accommodative strain
- elite association - COSMIC cancer census association via MalaCards
Search NCBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCBP1
genes like me logo Genes that share disorders with NCBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCBP1 Gene

Publications for NCBP1 Gene

  1. Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. (PMID: 7937105) Kataoka N. … Shimura Y. (Nucleic Acids Res. 1994) 2 3 4 23 67
  2. eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G. (PMID: 16156639) Marintchev A. … Wagner G. (Biochemistry 2005) 3 23
  3. Crystal structure of the human nuclear cap binding complex. (PMID: 11545740) Mazza C. … Cusack S. (Mol. Cell 2001) 3 23
  4. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. (PMID: 11551508) Ishigaki Y. … Maquat L.E. (Cell 2001) 3 23
  5. Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. (PMID: 10973943) Wilson K.F. … Cerione R.A. (J. Biol. Chem. 2000) 3 23

Products for NCBP1 Gene

Sources for NCBP1 Gene

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