NCBP1 Gene
protein-coding GIFtS: 56
GCID: GC09P100395
|
|
nuclear cap binding protein subunit 1, 80kDa(Previous names: nuclear cap binding protein subunit 1, 80kD )
(Previous symbol: NCBP)
| |
Aliases
for NCBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Cap Binding Protein Subunit 1, 80kDa1 2 | | 80 KDa Nuclear Cap-Binding Protein2 3 | | NCBP1 2 3 5 | | NCBP 80 KDa Subunit2 3 | | CBP801 2 3 | | Nuclear Cap Binding Protein Subunit 1, 80kD1 | | Sto11 2 | | Nuclear Cap-Binding Protein Subunit 12 |
Export aliases for NCBP1 gene to outside databasesPrevious GC identifers: GC09P091221 GC09P092139 GC09P093853 GC09P095775 GC09P097475 GC09P099435 GC09P069996 |
Summaries
for NCBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NCBP1:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to themonomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-capbinding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNAnuclear export, and nonsense-mediated mRNA decay. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161Function: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and isinvolved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay,RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA exportfrom the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery tothe 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is alsoinvolved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneerround of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-bindingprotein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role innonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-boundmRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interactionwith UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, whichis independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cellproliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN,thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly cappedRNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock theCBC into a high affinity cap-binding state with the cap structure
|
Genomic Views
for NCBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NCBP1 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for NCBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q34.1NCBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P100395: view genomic region
(about GC identifiers)
Start:
|
100,395,705 bp from pter |
End:
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100,436,030 bp from pter |
Size:
|
40,326 bases |
Orientation:
|
plus strand |
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Proteins
for NCBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161 (See
protein sequence)Recommended Name: Nuclear cap-binding protein subunit 1 Size: 790 amino acids; 91839 Da
Subunit: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 thatinteracts with m7GpppG-capped RNA. Found in a U snRNA export complex with RNUXA/PHAX, NCBP1/CBP80, NCBP2/CBP20, RAN,XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX (By similarity). Heterodimer with NCBP2. Identified in a mRNPgranule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR,HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9,SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2,RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, ALYREF/THOC4 and/or REFBP2. Interacts with SRRT/ARS2, EIF4G2, IGF2BP1, HNRNPF,HNRNPH1, KIAA0427/CTIF, PARN, DROSHA, UPF1 and ALYREF/THOC4. May interact with EIF4G1; the interaction is howevercontroversial since it is reported by PubMed:11340157, PubMed:15059963 and PubMed:15361857, but is not observed byPubMed:19648179
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Sequence caution: Sequence=BAD92470.1; Type=Erroneous initiation; Sequence=CAI12863.1; Type=Erroneous gene modelprediction;
6/8 PDB 3D structures from  and Proteopedia  for NCBP1 (see all 8):1H2T (3D)
1H2U (3D)
1H2V (3D)
1H6K (3D)
1N52 (3D)
1N54 (3D)
Secondary accessions: B2R718 Q59G76 Q5T1V0 Q5T7X2Explore the universe of human proteins at neXtProt for NCBP1: NX_Q09161
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q09161
NCBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002477.1
ENSEMBL proteins: ENSP00000364289 ENSP00000433007 ENSP00000364272 Reactome Protein details: Q09161
Human Recombinant Protein Products for NCBP1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NCBP1 for ontologies About GeneDecksing
NCBP1 Antibody Products:
Assay Products for NCBP1: |
Protein
Domains /
Families
for NCBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NCBP1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q09161ProtoNet protein and cluster: Q09161 1 Blocks protein family: IPB003890 Initiation factor eIF-4 gamma
UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161Similarity: Belongs to the NCBP1 familySimilarity: Contains 1 MIF4G domain |
Function
for NCBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NCBP1_HUMAN, Q09161Function: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and isinvolved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay,RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA exportfrom the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery tothe 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is alsoinvolved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneerround of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-bindingprotein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role innonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-boundmRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interactionwith UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, whichis independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cellproliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN,thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly cappedRNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock theCBC into a high affinity cap-binding state with the cap structure Genatlas biochemistry entry for NCBP1:nuclear cap binding protein 1,component of the cap-binding protein complex in association with NCBP2 and otherproteins,mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
NCBP1 for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for NCBP1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NCBP1 (NM_002486) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCBP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCBP1 |
|
Pathways & Interactions
for NCBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | mRNA Splicing - Major Pathway | | | 3 | RNA Polymerase II Transcription Termination | | | 4 | Synthesis of PB1-F2 | | | 5 | SLBP independent Processing of Histone Pre-mRNAs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for NCBP1
1  BioSystems Pathway for NCBP1
5/50 
Reactome Pathways for NCBP1 (see all 50)
3 
Kegg Pathways (Kegg details for NCBP1):
NCBP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/282 Interacting proteins for NCBP1 (Q091611, 2, 3 ENSP000003642894) via UniProtKB, MINT, STRING, and/or I2D (see all 282)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NCBP2 | P522981, 2, 3, ENSP000003268064 | EBI-464743,EBI-464729 MINT-24994 MINT-8335957 I2D:
score=7 STRING: ENSP00000326806 | | EIF4G1 | Q046372, 3, ENSP000003168794 | MINT-4791425 I2D:
score=4 STRING: ENSP00000316879 | | POLDIP3 | Q9BY771, 3, ENSP000002521154 | EBI-464743,EBI-1776152 I2D:
score=1 STRING: ENSP00000252115 | | RPS6 | P627531, 3, ENSP000003697574 | EBI-464743,EBI-356625 I2D:
score=1 STRING: ENSP00000369757 | | SF3A2 | Q154282, 3, ENSP000002214944 | MINT-5205917 I2D:
score=1 STRING: ENSP00000221494 |
About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0000387 | spliceosomal snRNP assembly |
TAS | -- | | GO:0000398 | mRNA splicing, via spliceosome |
TAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006368 | transcription elongation from RNA polymerase II promoter |
TAS | -- |
NCBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NCBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NCBP1
Search CenterWatch for drugs/clinical trials and news about NCBP1
|
Transcripts
for NCBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NCBP1 gene: NM_002486.4 Unigene Cluster for NCBP1: Nuclear cap binding protein subunit 1, 80kDa Hs.595669 [show with all ESTs]Unigene Representative Sequence: NM_0024864 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375147(uc004axq.3) ENST00000478100 ENST00000375130 ENST00000491445
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NCBP1 (NM_002486) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NCBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCBP1 |
Additional cDNA sequence: AB209233.1 AK312807.1 BC001450.2 D32002.1 X80030.1 20 DOTS entries: DT.95369662 DT.101961008 DT.86841494 DT.447205 DT.95369671 DT.102835149 DT.412404 DT.121158370 DT.65285061 DT.100693312 DT.121158243 DT.95336094 DT.121158266 DT.121158356 DT.121158364 DT.75140851 DT.95369664 DT.100685586 DT.100786207 DT.97785246 24/200 AceView cDNA sequences (see all 200): AI933007 AI868113 AI799881 BX462669 BU189554 AA482382 AI242582 AA436720 BU949532 BU176513 BC001450 AA810545 BG392612 BG179518 BU624686 CB121904 BX116966 Z45211 BU507238 AA905723 AU138969 AI926237 BG392148 AI081311
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NCBP1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | |
ECgene alternative splicing isoforms for NCBP1
|
Expression
for NCBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NCBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NCBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCBP1
SOURCE GeneReport for Unigene cluster: Hs.595669
SABiosciences Custom PCR Arrays for NCBP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCBP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCBP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCBP1 |
Orthologs
for NCBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NCBP1 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for NCBP1 (if available)
TreeFam Gene Tree for NCBP1 (if available) |
Paralogs
for NCBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NCBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NCBP1 (100395705 - 100436030 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NCBP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCBP1 |
|
Disorders
/ Diseases
for NCBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NCBP1 for disorders About GeneDecksing
OMIM gene information: 600469
OMIM disorders: --
3  diseases for NCBP1: About MalaCardsenamel erosion xeroderma pigmentosum asthenopia
1 disease from the University of Copenhagen DISEASES database for NCBP1:Asthenopia Export disorders for NCBP1 gene to outside databases
|
Publications
for NCBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NCBP1 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with NCBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. (PubMed id 7937105)1, 2, 3, 9 Kataoka N.... Shimura Y. (1994)
- Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. (PubMed id 11551508)1, 2, 9 Ishigaki Y.... Maquat L.E. (2001)
- Interaction between the human nuclear cap-binding protein complex and hnRNP F. (PubMed id 9111328)1, 2, 9 Gamberi C.... Mattaj I.W. (1997)
- Crystal structure of the human nuclear cap binding complex. (PubMed id 11545740)1, 2, 9 Mazza C.... Cusack S. (2001)
- Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. (PubMed id 10973943)1, 2, 9 Wilson K.F....Cerione R.A. (2000)
- A cap-binding protein complex mediating U snRNA export. (PubMed id 7651522)1, 2, 9 Izaurralde E....Mattaj A.W. (1995)
- A nuclear cap binding protein complex involved in pre-mRNA splicing. (PubMed id 8069914)1, 2, 9 Izaurralde E....Mattaj I.W. (1994)
- A new MIF4G domain-containing protein, CTIF, directs nuclear cap- binding protein CBP80/20-dependent translation. (PubMed id 19648179)1, 2 Kim K.M....Kim Y.K. (2009)
- SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. (PubMed id 18423201)1, 2 Ma X.M.... Blenis J. (2008)
- NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. (PubMed id 18369367)1, 2 Woeller C.F.... Maquat L.E. (2008)
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External Searches for NCBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NCBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NCBP1 gene
(According to HUGE)
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Specialized Databases showing NCBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for NCBP1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for NCBP1 gene:
Search GeneIP for patents involving NCBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NCBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NCBP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCBP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NCBP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NCBP1 | | OriGene 3'-UTR Clone for NCBP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCBP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NCBP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for NCBP1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCBP1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCBP1 |
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