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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCBP1 Gene

protein-coding   GIFtS: 58
GCID: GC09P100395

Nuclear Cap Binding Protein Subunit 1, 80kDa

(Previous names: nuclear cap binding protein subunit 1, 80kD)
(Previous symbol: NCBP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Cap Binding Protein Subunit 1, 80kDa1 2     NCBP 80 KDa Subunit2 3
NCBP1 2 3 5     Nuclear Cap Binding Protein Subunit 1, 80kD1
80 KDa Nuclear Cap-Binding Protein2 3     Sto12
CBP802 3     Nuclear Cap-Binding Protein Subunit 12

External Ids:    HGNC: 76581   Entrez Gene: 46862   Ensembl: ENSG000001369377   OMIM: 6004695   UniProtKB: Q091613   

Export aliases for NCBP1 gene to outside databases

Previous GC identifers: GC09P091221 GC09P092139 GC09P093853 GC09P095775 GC09P097475 GC09P099435 GC09P069996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCBP1 Gene:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the
monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap
binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing,
RNA nuclear export, and nonsense-mediated mRNA decay. (provided by RefSeq, Jul 2008)

GeneCards Summary for NCBP1 Gene: 
NCBP1 (nuclear cap binding protein subunit 1, 80kDa) is a protein-coding gene. Diseases associated with NCBP1 include asthenopia, and enamel erosion, and among its related super-pathways are mRNA Processing and Formation of HIV-1 elongation complex containing HIV-1 Tat. GO annotations related to this gene include RNA binding and RNA cap binding.

UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161
Function: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs
and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA
decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in
mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA
export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The
CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex
is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is
replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC
complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the
CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one
exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The
CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not
participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in
microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA
interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA
deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is
required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity
cap-binding state with the cap structure




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCBP1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q34.1

NCBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCBP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100395:  view genomic region     (about GC identifiers)

Start:
100,395,705 bp from pter      End:
100,436,030 bp from pter
Size:
40,326 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161 (See protein sequence)
Recommended Name: Nuclear cap-binding protein subunit 1  
Size: 790 amino acids; 91839 Da
Subunit: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20
that interacts with m7GpppG-capped RNA. Found in a U snRNA export complex with RNUXA/PHAX, NCBP1/CBP80,
NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX (By similarity). Heterodimer with NCBP2.
Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB,
HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,
RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Is part of the exon junction
complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, ALYREF/THOC4 and/or
ALYREF2/REFBP2. Interacts with SRRT/ARS2, EIF4G2, IGF2BP1, HNRNPF, HNRNPH1, KIAA0427/CTIF, PARN, DROSHA, UPF1 and
ALYREF/THOC4. May interact with EIF4G1; the interaction is however controversial since it is reported by
PubMed:11340157, PubMed:15059963 and PubMed:15361857, but is not observed by PubMed:19648179
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
mRNAs
Sequence caution: Sequence=BAD92470.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAI12863.1; Type=Erroneous gene model prediction;
6/8 PDB 3D structures from and Proteopedia for NCBP1 (see all 8):
1H2T (3D)        1H2U (3D)        1H2V (3D)        1H6K (3D)        1N52 (3D)        1N54 (3D)    
Secondary accessions: B2R718 Q59G76 Q5T1V0 Q5T7X2

Explore the universe of human proteins at neXtProt for NCBP1: NX_Q09161

Explore proteomics data for NCBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q09161

  • NCBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCBP1 Protein Expression
    REFSEQ proteins: NP_002477.1  
    ENSEMBL proteins: 
     ENSP00000364289   ENSP00000433007   ENSP00000364272  
    Reactome Protein details: Q09161
    Human Recombinant Protein Products for NCBP1: 
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    Cloud-Clone Corp. Proteins for NCBP1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19648179
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005845mRNA cap binding complex IDA12434151
    GO:0005846nuclear cap binding complex IEA--

    NCBP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR003890 MIF4G-like_typ-3
     IPR016021 MIF4-like_typ_1/2/3
     IPR027159 CBP80
     IPR015172 MIF4G-like_typ-1
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q09161

    ProtoNet protein and cluster: Q09161

    1 Blocks protein domain: IPB003890 Initiation factor eIF-4 gamma

    UniProtKB/Swiss-Prot: NCBP1_HUMAN, Q09161
    Similarity: Belongs to the NCBP1 family
    Similarity: Contains 1 MIF4G domain


    NCBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCBP1_HUMAN, Q09161
    Function: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs
    and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA
    decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in
    mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA
    export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The
    CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex
    is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is
    replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC
    complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the
    CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one
    exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The
    CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not
    participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in
    microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA
    interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA
    deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is
    required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity
    cap-binding state with the cap structure

         Genatlas biochemistry entry for NCBP1:
    nuclear cap binding protein 1,component of the cap-binding protein complex in association with NCBP2 and other
    proteins,mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000339RNA cap binding IEA--
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding TAS8069914
    GO:0005488binding ----
    GO:0005515protein binding IPI12374755
         
    NCBP1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for NCBP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NCBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCBP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCBP1 

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    SwitchGear 3'UTR luciferase reporter plasmidNCBP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCBP1 About   (see all 18)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    RNA Polymerase II Transcription Elongation0.76
    Tat-mediated elongation of the HIV-1 transcript0.78
    Formation of RNA Pol II elongation complex 0.76
    HIV Transcription Elongation0.78
    RNA Polymerase II Pre-transcription Events0.72
    3RNA Polymerase II Transcription Termination
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    RNA Polymerase II Transcription Termination0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    Post-Elongation Processing of the Transcript0.79
    mRNA 3'-end processing0.79
    4Viral mRNA Translation
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84
    Nonsense-Mediated Decay0.84
    5HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NCBP1
        Translational Control

    1 BioSystems Pathway for NCBP1
        mRNA processing

    5/47        Reactome Pathways for NCBP1 (see all 47)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Tat-mediated elongation of the HIV-1 transcript
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    Cleavage of Growing Transcript in the Termination Region


    3         Kegg Pathways  (Kegg details for NCBP1):
        RNA transport
    mRNA surveillance pathway
    Spliceosome


    NCBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NCBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/282 Interacting proteins for NCBP1 (Q091611, 2, 3 ENSP000003642894) via UniProtKB, MINT, STRING, and/or I2D (see all 282)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCBP2P522981, 2, 3, ENSP000003268064EBI-464743,EBI-464729 MINT-24994 MINT-8335957 I2D: score=7 STRING: ENSP00000326806
    EIF4G1Q046372, 3, ENSP000003168794MINT-4791425 I2D: score=4 STRING: ENSP00000316879
    POLDIP3Q9BY771, 3, ENSP000002521154EBI-464743,EBI-1776152 I2D: score=1 STRING: ENSP00000252115
    RPS6P627531, 3, ENSP000003697574EBI-464743,EBI-356625 I2D: score=1 STRING: ENSP00000369757
    SF3A2Q154282, 3, ENSP000002214944MINT-5205917 I2D: score=1 STRING: ENSP00000221494
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    NCBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCBP1

    Search CenterWatch for drugs/clinical trials and news about NCBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NCBP1 gene: 
    NM_002486.4  

    Unigene Cluster for NCBP1:

    Nuclear cap binding protein subunit 1, 80kDa
    Hs.595669  [show with all ESTs]
    Unigene Representative Sequence: NM_002486
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375147(uc004axq.3) ENST00000478100 ENST00000375130 ENST00000491445

    Congresses - knowledge worth sharing:  
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    Additional mRNA sequence: 

    AB209233.1 AK312807.1 BC001450.2 D32002.1 X80030.1 

    20 DOTS entries:

    DT.95369662  DT.101961008  DT.86841494  DT.447205  DT.95369671  DT.102835149  DT.412404  DT.121158370 
    DT.65285061  DT.100693312  DT.121158243  DT.95336094  DT.121158266  DT.121158356  DT.121158364  DT.75140851 
    DT.95369664  DT.100685586  DT.100786207  DT.97785246 

    24/200 AceView cDNA sequences (see all 200):

    BG392612 BX099181 AA076305 AI799881 BX462669 Z40939 BU949532 AA912932 
    AA442516 AI081311 AA468545 BU176513 AW051577 BE464654 AA436720 AI129344 
    AU138969 AA886393 BX365349 AU135678 AA810545 AI933007 AA905723 AA482382 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NCBP1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                      -     -                                                                                                               
    SP2:                                      -     -     -                 -                                                                                       
    SP3:                                            -                                                                                                               
    SP4:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        


    ECgene alternative splicing isoforms for NCBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCBP1 Expression
    About this image


    See NCBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCBP1

    SOURCE GeneReport for Unigene cluster: Hs.595669
        SABiosciences Custom PCR Arrays for NCBP1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCBP1 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncbp11 , 5 nuclear cap binding protein subunit 11, 5 89.54(n)1
    97.97(a)1
      4 (24.49 cM)5
    4337021  NM_001033201.31  NP_001028373.21 
     461386135 
    chicken
    (Gallus gallus)
    Aves NCBP11 nuclear cap binding protein subunit 1, 80kDa 80.89(n)
    90.63(a)
      427379  NM_001031440.1  NP_001026611.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCBP16
    nuclear cap binding protein subunit 1, 80kDa
    76(a)
    1 ↔ 1
    GL343544.1(63494-103975)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.29842 Xenopus laevis transcribed sequence with moderate similarity more 74.69(n)    BU903252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NCBP1 (2 of 2)6
    NCBP1 (1 of 2)6
    nuclear cap binding protein subunit 1, 80kDa
    58(a)
    40(a)
    many → 1
    many → 1
    14(53351123-53353384)
    14(53293150-53294736)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cbp801 , 3 mRNA splicing RNA cap binding3
    cap binding protein 801
    56(a)
    (best of 2)3
    56.88(n)1
    58.73(a)1
      4C113
    444091  NM_080011.21  NP_524750.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F37E3.13
    ncbp-11
    CAP-binding protein3
    Protein NCBP-11
    33(a)3
    48.34(n)1
    35.87(a)1
      I(6430171-6433618)3
    1723451  NM_059449.41  NP_491850.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STO1(YMR125W)4 Large subunit of the nuclear mRNA cap-binding protein more   --   13(517539-520446) 855155  NP_013844.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ABH11 nuclear cap-binding protein subunit 1 44.51(n)
    31.46(a)
      815840  NM_126934.3  NP_565356.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03472001 hypothetical protein 44.12(n)
    31.32(a)
      4332822  NM_001056632.1  NP_001050097.1 


    ENSEMBL Gene Tree for NCBP1 (if available)
    TreeFam Gene Tree for NCBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/781 SNPs in NCBP1 are shown (see all 781)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496558391,2
    --100398000(+) CGCCCA/GCCGAT 1 -- int10--------
    rs1878649081,2
    --100398086(+) AGAACG/TTGAGT 1 -- int10--------
    rs790016001,2
    C,F--100398109(+) TCTTTG/CTTGTT 1 -- int11Minor allele frequency- C:0.08EA 120
    rs1454694231,2
    --100398213(+) GAAAAA/GTAACT 1 -- int10--------
    rs27733491,2
    C,F,H--100398254(+) CTTTCT/CTGGAG 1 -- int18Minor allele frequency- C:0.13EA NS NA WA 750
    rs1495761201,2
    C--100398336(+) TAAAT-/AAGAC 
            
    AAGTA
    1 -- int10--------
    rs1998698821,2
    --100398473(+) ACGAT-/CCGCTG 1 -- int10--------
    rs583522351,2
    C--100398474(+) CGATCA/-GCTGG 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs718839481,2
    C--100398475(+) GATCG-/ACTGGA 1 -- int10--------
    rs1160012621,2
    F--100398746(+) ATAGAA/GTGTAT 1 -- int11Minor allele frequency- G:0.36WA 118

    HapMap Linkage Disequilibrium report for NCBP1 (100395705 - 100436030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NCBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893610CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600469    OMIM disorders: --

    5 diseases for NCBP1:    About MalaCards
    asthenopia    enamel erosion    xeroderma pigmentosum    kaposi's sarcoma
    sarcoma

    1 disease from the University of Copenhagen DISEASES database for NCBP1:
    Asthenopia

    NCBP1 for disorders           About GeneDecksing


    Export disorders for NCBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCBP1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with NCBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. (PubMed id 7937105)1, 2, 3, 9 Kataoka N.... Shimura Y. (1994)
    2. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. (PubMed id 11551508)1, 2, 9 Ishigaki Y.... Maquat L.E. (2001)
    3. Interaction between the human nuclear cap-binding protein complex and hnRNP F. (PubMed id 9111328)1, 2, 9 Gamberi C.... Mattaj I.W. (1997)
    4. Crystal structure of the human nuclear cap binding complex. (PubMed id 11545740)1, 2, 9 Mazza C.... Cusack S. (2001)
    5. Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. (PubMed id 10973943)1, 2, 9 Wilson K.F....Cerione R.A. (2000)
    6. A cap-binding protein complex mediating U snRNA export. (PubMed id 7651522)1, 2, 9 Izaurralde E....Mattaj A.W. (1995)
    7. A nuclear cap binding protein complex involved in pre-mRNA splicing. (PubMed id 8069914)1, 2, 9 Izaurralde E....Mattaj I.W. (1994)
    8. A new MIF4G domain-containing protein, CTIF, directs nuclear cap- binding protein CBP80/20-dependent translation. (PubMed id 19648179)1, 2 Kim K.M....Kim Y.K. (2009)
    9. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. (PubMed id 18423201)1, 2 Ma X.M.... Blenis J. (2008)
    10. NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. (PubMed id 18369367)1, 2 Woeller C.F.... Maquat L.E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4686 HGNC: 7658 AceView: NCBP1 Ensembl:ENSG00000136937 euGenes: HUgn4686
    ECgene: NCBP1 Kegg: 4686 H-InvDB: NCBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCBP1 gene:
    Search GeneIP for patents involving NCBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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