Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NCAPH2 Gene

protein-coding   GIFtS: 51
GCID: GC22P050946

Non-SMC Condensin II Complex, Subunit H2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Non-SMC Condensin II Complex, Subunit H21 2     CTA-384D8.362
CAPH22 3 5     Condensin-2 Complex Subunit H22
CAP-H2 Subunit Of The Condensin II Complex1 2     Kleisin-beta3
Kleisin Beta1 2     hCAP-H23
Chromosome-Associated Protein H22 3     Non-SMC Condensin II Complex Subunit H23

External Ids:    HGNC: 250711   Entrez Gene: 297812   Ensembl: ENSG000000257707   OMIM: 6112305   UniProtKB: Q6IBW43   

Export aliases for NCAPH2 gene to outside databases

Previous GC identifers: GC22P049293 GC22P033837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NCAPH2 Gene:
This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in
mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.(provided by
RefSeq, May 2010)

GeneCards Summary for NCAPH2 Gene:
NCAPH2 (non-SMC condensin II complex, subunit H2) is a protein-coding gene.

UniProtKB/Swiss-Prot: CNDH2_HUMAN, Q6IBW4
Function: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an
additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a
role in lineage-specific role in T-cell development (By similarity)

Gene Wiki entry for NCAPH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the NCAPH2 gene promoter:
         AP-2gamma   PPAR-gamma1   SEF-1 (1)   AP-2beta   ZIC2/Zic2   PPAR-gamma2   AP-2alpha   Ik-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAPH2 promoter sequence
   Search Chromatin IP Primers for NCAPH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAPH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

NCAPH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAPH2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050946:  view genomic region     (about GC identifiers)

Start:
50,946,645 bp from pter      End:
50,963,209 bp from pter
Size:
16,565 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNDH2_HUMAN, Q6IBW4 (See protein sequence)
Recommended Name: Condensin-2 complex subunit H2  
Size: 605 amino acids; 68227 Da
Subunit: Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC
subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex
Sequence caution: Sequence=AAB03345.1; Type=Erroneous gene model prediction; Sequence=AAH00473.1; Type=Erroneous
initiation; Sequence=AAH01509.1; Type=Erroneous initiation; Sequence=AAH01833.1; Type=Erroneous initiation;
Sequence=AAH01937.1; Type=Erroneous initiation; Sequence=AAH09441.1; Type=Erroneous initiation;
Sequence=CAA16670.1; Type=Frameshift; Positions=56, 429; Sequence=EAW73552.1; Type=Erroneous gene model
prediction;
Secondary accessions: B7WPH1 O43788 Q13391 Q96C14 Q96GJ0 Q9BQ71 Q9BUT3 Q9BVD1
Alternative splicing: 4 isoforms:  Q6IBW4-1   Q6IBW4-2   Q6IBW4-5   Q6IBW4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NCAPH2: NX_Q6IBW4

Explore proteomics data for NCAPH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NCAPH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171940.1  NP_055366.3  NP_689512.2  

    ENSEMBL proteins: 
     ENSP00000410088   ENSP00000379050   ENSP00000379053   ENSP00000429060   ENSP00000429025  
     ENSP00000410480   ENSP00000299821   ENSP00000430944  
    Reactome Protein details: Q6IBW4

    NCAPH2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NCAPH2
    OriGene Protein Over-expression Lysate for NCAPH2
    OriGene MassSpec for NCAPH2
    OriGene Custom Protein Services for NCAPH2
    GenScript Custom Purified and Recombinant Proteins Services for NCAPH2
    Novus Biologicals NCAPH2 Protein
    Novus Biologicals NCAPH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCAPH2

     
    Search eBioscience for Proteins for NCAPH2 

     
    antibodies-online proteins for NCAPH2 (3 products) 

     
    antibodies-online peptides for NCAPH2

    NCAPH2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NCAPH2
    Novus Biologicals NCAPH2 Antibodies
    Abcam antibodies for NCAPH2
    Cloud-Clone Corp. Antibodies for NCAPH2
    ThermoFisher Antibodies for NCAPH2
    LSBio Antibodies in human, mouse, rat for NCAPH2
    antibodies-online antibodies for NCAPH2 (19 products) 

    NCAPH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NCAPH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCAPH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCAPH2
    Cloud-Clone Corp. CLIAs for NCAPH2
    Search eBioscience for ELISAs for NCAPH2 
    antibodies-online kits for NCAPH2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009378 Condensin_II_H2-like

    Graphical View of Domain Structure for InterPro Entry Q6IBW4

    ProtoNet protein and cluster: Q6IBW4

    UniProtKB/Swiss-Prot: CNDH2_HUMAN, Q6IBW4
    Similarity: Belongs to the CND2 H2 (condensin-2 subunit 2) family


    Find genes that share domains with NCAPH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNDH2_HUMAN, Q6IBW4
    Function: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an
    additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a
    role in lineage-specific role in T-cell development (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17268547
         
    Find genes that share ontologies with NCAPH2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ncaph2):
     hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with NCAPH2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCAPH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCAPH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCAPH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCAPH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCAPH2:
    hsa-mir-124-3p (MIRT022333), hsa-mir-193b-3p (MIRT016269)

    Block miRNA regulation of human, mouse, rat NCAPH2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NCAPH2:
    hsa-miR-3194-5p hsa-miR-196a*
    SwitchGear 3'UTR luciferase reporter plasmidNCAPH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NCAPH2
    Predesigned siRNA for gene silencing in human, mouse, rat NCAPH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCAPH2

    Clone
    Products:
         
    OriGene clones in human, mouse for NCAPH2 (see all 19)
    OriGene ORF clones in mouse, rat for NCAPH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NCAPH2 (NM_014551)
    Sino Biological Human cDNA Clone for NCAPH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCAPH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAPH2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NCAPH2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NCAPH2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CNDH2_HUMAN, Q6IBW4: Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in
    vitro
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with NCAPH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NCAPH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Condensation of Prophase Chromosomes0.78
    Mitotic Prophase0.56
    3Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase


    Find genes that share SuperPaths with NCAPH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NCAPH2
        Cell cycle Chromosome condensation in prometaphase


    1 Reactome Pathway for NCAPH2
        Condensation of Prophase Chromosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCAPH2
    Interactions:

        Search GeneGlobe Interaction Network for NCAPH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NCAPH2 (Q6IBW41, 2, 3 ENSP000004100884) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAPG2Q86XI21, 2, 3, ENSP000003486574EBI-2548296,EBI-1047404 MINT-4329926 MINT-4330086 I2D: score=1 STRING: ENSP00000348657
    NCAPD3P426951, 2, 3EBI-2548296,EBI-722805 MINT-4329904 MINT-4330100 I2D: score=1 
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0030261chromosome condensation IEA--

    Find genes that share ontologies with NCAPH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCAPH2 (CNDH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NCAPH2 gene (3 alternative transcripts): 
    NM_001185011.1  NM_014551.4  NM_152299.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420993(uc003blx.4 uc003blr.4) ENST00000395698(uc003blq.4)
    ENST00000395701(uc003blv.3) ENST00000518394 ENST00000523045 ENST00000418794
    ENST00000299821 ENST00000520297 ENST00000522048 ENST00000522304
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NCAPH2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NCAPH2:
    hsa-miR-3194-5p hsa-miR-196a*
    SwitchGear 3'UTR luciferase reporter plasmidNCAPH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NCAPH2
    Predesigned siRNA for gene silencing in human, mouse, rat NCAPH2
    Clone
    Products:
         
    OriGene clones in human, mouse for NCAPH2 (see all 19)
    OriGene ORF clones in mouse, rat for NCAPH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NCAPH2 (NM_014551)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCAPH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAPH2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NCAPH2
    OriGene qSTAR qPCR primer pairs in human, mouse for NCAPH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCAPH2
      QuantiTect SYBR Green Assays in human, mouse, rat NCAPH2
      QuantiFast Probe-based Assays in human, mouse, rat NCAPH2

    Selected AceView cDNA sequences (see all 439):

    BE733351 AA846693 F11333 BQ647754 BG390294 BQ083868 CR456604 BX407000 
    AI347059 CR601437 BI908520 BM678017 CR626715 BX388245 BI836303 AA906871 
    AA948279 BM808342 BC001298 CB120671 BM724104 BQ675089 BM713550 BQ896683 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCAPH2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                          -     -                                         -                                 
    SP2:                                                                          -     -                                         -                                 
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NCAPH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NCAPH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGCCCT
    NCAPH2 Expression
    About this image


    NCAPH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    NCAPH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCAPH2 Protein Expression
        Custom PCR Arrays for NCAPH2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NCAPH2
    OriGene qSTAR qPCR primer pairs in human, mouse for NCAPH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCAPH2
    QuantiTect SYBR Green Assays in human, mouse, rat NCAPH2
    QuantiFast Probe-based Assays in human, mouse, rat NCAPH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NCAPH2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncaph21 , 5 non-SMC condensin II complex, subunit H21, 5 81.59(n)1
    81.48(a)1
      15 (44.84 cM)5
    526831  NM_001115132.21  NP_001108604.11 
     893557195 
    chicken
    (Gallus gallus)
    Aves NCAPH21 non-SMC condensin II complex, subunit H2 66.38(n)
    60(a)
      426276  XM_004937402.1  XP_004937459.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCAPH26
    non-SMC condensin II complex, subunit H2
    53(a)
    1 ↔ 1
    AAWZ02036645(894-20095)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238622 Xenopus laevis transcribed sequence with weak similarity more 72.75(n)    CA987719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncaph21 non-SMC condensin II complex, subunit H2 52.19(n)
    44.48(a)
      562678  NM_001044991.1  NP_001038456.1 


    ENSEMBL Gene Tree for NCAPH2 (if available)
    TreeFam Gene Tree for NCAPH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NCAPH2 (see all 500)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392191911,2
    Cuntested150956684(+) CGTTTA/C/GCCCCA 6 Y S mis10--------
    rs1318221,2
    C,F,A--50948310(-) GAAGAT/CCTTCC 3 -- int113Minor allele frequency- C:0.48NA WA CSA EA 376
    rs1932100471,2
    --50948319(+) TCATGC/TTTTCT 3 -- int10--------
    rs1150588881,2
    C--50948356(+) GTTTTC/TATTTA 3 -- int10--------
    rs60101231,2
    C,F,A,H--50948391(+) gtctcG/Actctg 3 -- int18Minor allele frequency- A:0.12NS EA NA WA CSA 530
    rs1512879831,2
    --50948416(+) TGGCGC/TGATCT 3 -- int10--------
    rs1405464401,2
    C--50948499(+) GCGCCC/TGCCTC 3 -- int10--------
    rs1459206961,2
    --50948504(+) CGCCTC/TCACGC 3 -- int10--------
    rs1384673411,2
    C--50948649(+) CCGGCC/TTCTTT 3 -- int10--------
    rs110910031,2
    C,F--50948652(+) gccTCC/TTTTTT 3 -- int1 trp31Minor allele frequency- T:0.00WA 2

    HapMap Linkage Disequilibrium report for NCAPH2 (50946645 - 50963209 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NCAPH2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2005211CNV Deletion18987734
    esv2667238CNV Deletion23128226
    esv2343148CNV Deletion18987734
    nsv3669CNV Insertion18451855
    nsv915495CNV Loss21882294
    dgv5065n71CNV Loss21882294
    nsv834238CNV Loss17160897
    dgv5064n71CNV Loss21882294
    nsv834239CNV Loss17160897
    dgv5066n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NCAPH2
    DNA2.0 Custom Variant and Variant Library Synthesis for NCAPH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611230    OMIM disorders: --


    Find genes that share disorders with NCAPH2           About GenesLikeMe

    Genetic Association Database (GAD): NCAPH2
    Human Genome Epidemiology (HuGE) Navigator: NCAPH2 (3 documents)

    Export disorders for NCAPH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NCAPH2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NCAPH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    3. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. (PubMed id 14532007)1, 2 Ono T.... Hirano T. (Cell 2003)
    4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 3 Loftus B.J.... Adams M.D. (Genomics 1999)
    5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    6. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29781 HGNC: 25071 AceView: 384D8-2 Ensembl:ENSG00000025770 euGenes: HUgn29781
    ECgene: NCAPH2 H-InvDB: NCAPH2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NCAPH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NCAPH2 gene:
    Search GeneIP for patents involving NCAPH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NCAPH2  
     OriGene qPCR primer pairs and template standards for NCAPH2   OriGene Protein Over-expression Lysate for NCAPH2  
     OriGene MassSpec for NCAPH2   OriGene clones in human, mouse for NCAPH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NCAPH2   OriGene Purified Protein for NCAPH2  
     OriGene ORF clones in mouse, rat for NCAPH2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NCAPH2   OriGene Custom Protein Services for NCAPH2  

     
     
     Block miRNA regulation of human, mouse, rat NCAPH2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NCAPH2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAPH2 Predesigned siRNA for gene silencing in human, mouse, rat NCAPH2
     QuantiFast Probe-based Assays in human, mouse, rat NCAPH2 QuantiTect SYBR Green Assays in human, mouse, rat NCAPH2
     Custom PCR Arrays for NCAPH2 Search Chromatin IP Primers for NCAPH2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCAPH2  Search GeneGlobe Interaction Network for NCAPH2
     Regulatory tfbs in NCAPH2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NCAPH2 GenScript cDNA clones with any tag delivered in your preferred vector for NCAPH2
     GenScript Custom Assay Services for NCAPH2 GenScript Custom overexpressing Cell Line Services for NCAPH2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NCAPH2 (CNDH2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NCAPH2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NCAPH2 antibodies
     NCAPH2 proteins
     NCAPH2 lysates
     Antibodies for NCAPH2
     See all of Abcam's Antibodies, Kits and Proteins for NCAPH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NCAPH2
     Antibodies for NCAPH2
     ELISAs for NCAPH2
     CLIAs for NCAPH2



     Browse ESI BIO Cell Lines and PureStem Progenitors for NCAPH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPH2
     SwitchGear 3'UTR luciferase reporter plasmids for NCAPH2
     SwitchGear Promoter luciferase reporter plasmids for NCAPH2
     ThermoFisher Antibodies for NCAPH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAPH2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCAPH2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCAPH2
     LSBio Antibodies in human, mouse, rat for NCAPH2
     Browse compounds at ApexBio
     Search Addgene for plasmids for NCAPH2
      Search eBioscience for proteins for NCAPH2
      Search eBioscience for elisas for NCAPH2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for NCAPH2 (19 products)
     antibodies-online kits for NCAPH2 (8 products)
     antibodies-online peptides for NCAPH2
     antibodies-online proteins for NCAPH2 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NCAPH2 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4