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Aliases for NCAPH2 Gene

Aliases for NCAPH2 Gene

  • Non-SMC Condensin II Complex, Subunit H2 2 3
  • CAPH2 3 4 6
  • CAP-H2 Subunit Of The Condensin II Complex 2 3
  • Chromosome-Associated Protein H2 3 4
  • Kleisin Beta 2 3
  • Non-SMC Condensin II Complex Subunit H2 4
  • Condensin-2 Complex Subunit H2 3
  • CTA-384D8.36 3
  • Kleisin-Beta 4
  • HCAP-H2 4

External Ids for NCAPH2 Gene

Previous GeneCards Identifiers for NCAPH2 Gene

  • GC22P049293
  • GC22P050946
  • GC22P033837

Summaries for NCAPH2 Gene

Entrez Gene Summary for NCAPH2 Gene

  • This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for NCAPH2 Gene

NCAPH2 (Non-SMC Condensin II Complex, Subunit H2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NCAPH2 Gene

  • Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a role in lineage-specific role in T-cell development (By similarity).

Gene Wiki entry for NCAPH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPH2 Gene

Genomics for NCAPH2 Gene

Regulatory Elements for NCAPH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCAPH2 Gene

Start:
50,508,216 bp from pter
End:
50,524,780 bp from pter
Size:
16,565 bases
Orientation:
Plus strand

Genomic View for NCAPH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPH2 Gene

Proteins for NCAPH2 Gene

  • Protein details for NCAPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IBW4-CNDH2_HUMAN
    Recommended name:
    Condensin-2 complex subunit H2
    Protein Accession:
    Q6IBW4
    Secondary Accessions:
    • B7WPH1
    • O43788
    • Q13391
    • Q96C14
    • Q96GJ0
    • Q9BQ71
    • Q9BUT3
    • Q9BVD1

    Protein attributes for NCAPH2 Gene

    Size:
    605 amino acids
    Molecular mass:
    68227 Da
    Quaternary structure:
    • Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex.
    SequenceCaution:
    • Sequence=AAB03345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH00473.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01509.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01833.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01937.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09441.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA16670.1; Type=Frameshift; Positions=56, 429; Evidence={ECO:0000305}; Sequence=EAW73552.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NCAPH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAPH2 Gene

Proteomics data for NCAPH2 Gene at MOPED

Post-translational modifications for NCAPH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCAPH2 Gene

Antibody Products

No data available for DME Specific Peptides for NCAPH2 Gene

Domains for NCAPH2 Gene

Protein Domains for NCAPH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAPH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IBW4

UniProtKB/Swiss-Prot:

CNDH2_HUMAN :
  • Q6IBW4
Family:
  • Belongs to the CND2 H2 (condensin-2 subunit 2) family.
genes like me logo Genes that share domains with NCAPH2: view

No data available for Gene Families for NCAPH2 Gene

Function for NCAPH2 Gene

Molecular function for NCAPH2 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a role in lineage-specific role in T-cell development (By similarity).

Gene Ontology (GO) - Molecular Function for NCAPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17268547
genes like me logo Genes that share ontologies with NCAPH2: view

Phenotypes for NCAPH2 Gene

genes like me logo Genes that share phenotypes with NCAPH2: view

Animal Model Products

CRISPR Products

miRNA for NCAPH2 Gene

miRTarBase miRNAs that target NCAPH2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPH2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCAPH2 Gene

Localization for NCAPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPH2 Gene

Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPH2 Gene COMPARTMENTS Subcellular localization image for NCAPH2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NCAPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NCAPH2: view

Pathways for NCAPH2 Gene

genes like me logo Genes that share pathways with NCAPH2: view

Pathways by source for NCAPH2 Gene

1 GeneGo (Thomson Reuters) pathway for NCAPH2 Gene

Gene Ontology (GO) - Biological Process for NCAPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with NCAPH2: view

Transcripts for NCAPH2 Gene

Unigene Clusters for NCAPH2 Gene

Non-SMC condensin II complex, subunit H2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPH2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: - -
SP7:

Relevant External Links for NCAPH2 Gene

GeneLoc Exon Structure for
NCAPH2
ECgene alternative splicing isoforms for
NCAPH2

Expression for NCAPH2 Gene

mRNA expression in normal human tissues for NCAPH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPH2 Gene

SOURCE GeneReport for Unigene cluster for NCAPH2 Gene Hs.730607

genes like me logo Genes that share expressions with NCAPH2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAPH2 Gene

Orthologs for NCAPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCAPH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPH2 35
  • 99.17 (n)
  • 99.01 (a)
NCAPH2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCAPH2 35
  • 85 (n)
  • 79.83 (a)
NCAPH2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPH2 35
  • 85.75 (n)
  • 82.49 (a)
NCAPH2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7535 36
  • 79 (a)
OneToMany
Ncaph2 35
  • 81.59 (n)
  • 81.48 (a)
Ncaph2 16
Ncaph2 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NCAPH2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPH2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncaph2 35
  • 80.82 (n)
  • 80.51 (a)
chicken
(Gallus gallus)
Aves NCAPH2 35
  • 66.38 (n)
  • 60 (a)
NCAPH2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPH2 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23862 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncaph2 35
  • 59.65 (n)
  • 57.72 (a)
Str.1022 35
zebrafish
(Danio rerio)
Actinopterygii ncaph2 35
  • 52.19 (n)
  • 44.48 (a)
ncaph2 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for NCAPH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAPH2 Gene

ENSEMBL:
Gene Tree for NCAPH2 (if available)
TreeFam:
Gene Tree for NCAPH2 (if available)

Paralogs for NCAPH2 Gene

No data available for Paralogs for NCAPH2 Gene

Variants for NCAPH2 Gene

Sequence variations from dbSNP and Humsavar for NCAPH2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131813 -- 50,522,740(-) CCGTC(C/T)CCCTC intron-variant
rs131814 -- 50,521,672(-) CCCCC(C/T)ACCTC intron-variant
rs131815 -- 50,521,179(-) CATGA(A/G)GGGGT intron-variant
rs131816 -- 50,519,033(-) GCTCT(A/G/T)TGCTC intron-variant
rs131817 -- 50,517,109(-) GGTGG(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPH2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv3669 CNV Insertion 18451855
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897
dgv1422e1 CNV Complex 17122850
dgv5066n71 CNV Loss 21882294
nsv914552 CNV Loss 21882294
nsv914554 CNV Loss 21882294
nsv829340 CNV Gain 20364138
esv2343148 CNV Deletion 18987734
esv2667238 CNV Deletion 23128226
dgv5067n71 CNV Loss 21882294
esv2005211 CNV Deletion 18987734
nsv914556 CNV Loss 21882294

Relevant External Links for NCAPH2 Gene

HapMap Linkage Disequilibrium report
NCAPH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPH2 Gene

Disorders for NCAPH2 Gene

Relevant External Links for NCAPH2

Genetic Association Database (GAD)
NCAPH2
Human Genome Epidemiology (HuGE) Navigator
NCAPH2
genes like me logo Genes that share disorders with NCAPH2: view

No data available for UniProtKB/Swiss-Prot for NCAPH2 Gene

Publications for NCAPH2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. (PMID: 14532007) Ono T. … Hirano T. (Cell 2003) 3 4
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NCAPH2 Gene

Sources for NCAPH2 Gene

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