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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCAPH Gene

protein-coding   GIFtS: 56
GCID: GC02P097001

Non-SMC Condensin I Complex, Subunit H

(Previous names: barren (Drosophila) homolog, barren homolog (Drosophila),...)
(Previous symbol: BRRN1)
  Search for NCAPH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Non-SMC Condensin I Complex, Subunit H1 2     Condensin Complex Subunit 22
BRRN11 2 3 5     BRRN3
Chromosome-Associated Protein H2 3     CAPH3
Barren (Drosophila) Homolog1     KIAA00743
Barren Homolog (Drosophila)1     Barren Homolog Protein 13
Barren Homolog 1 (Drosophila)1     hCAP-H3
CAP-H2     Non-SMC Condensin I Complex Subunit H3
Barren Homolog 12     XCAP-H Homolog3

External Ids:    HGNC: 11121   Entrez Gene: 233972   Ensembl: ENSG000001211527   OMIM: 6023325   UniProtKB: Q150033   

Export aliases for NCAPH gene to outside databases

Previous GC identifers: GC02P096365 GC02P090962


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCAPH Gene:
This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex
is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this
gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During
interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants
encoding different proteins have been described. (provided by RefSeq, Jul 2013)

GeneCards Summary for NCAPH Gene: 
NCAPH (non-SMC condensin I complex, subunit H) is a protein-coding gene. Among its related super-pathways are Mitotic M-M/G1 phases and Cell Cycle, Mitotic. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CND2_HUMAN, Q15003
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
presence of type II topoisomerases

Gene Wiki entry for NCAPH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCAPH gene promoter:
         AREB6   RP58   Tal-1   MyoD   FOXD1   c-Myb   Zic3   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAPH promoter sequence
   Search SABiosciences Chromatin IP Primers for NCAPH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCAPH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

NCAPH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAPH gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P097001:  view genomic region     (about GC identifiers)

Start:
97,001,484 bp from pter      End:
97,041,274 bp from pter
Size:
39,791 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CND2_HUMAN, Q15003 (See protein sequence)
Recommended Name: Condensin complex subunit 2  
Size: 741 amino acids; 82563 Da
Subunit: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC
subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG
Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin
complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation
of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the
condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the
complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome
condensation. Dissociation from chromosomes is observed in late telophase
Sequence caution: Sequence=BAA07556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TB87

Explore the universe of human proteins at neXtProt for NCAPH: NX_Q15003

Explore proteomics data for NCAPH at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin
    complex and is required for chromosome condensation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15003

  • NCAPH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCAPH Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001268639.1  NP_001268640.1  NP_001268641.1  NP_056156.2  

    ENSEMBL proteins: 
     ENSP00000240423   ENSP00000400774   ENSP00000405237   ENSP00000401227   ENSP00000407308  
     ENSP00000415162  
    Reactome Protein details: Q15003
    Human Recombinant Protein Products for NCAPH: 
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    Novus Biologicals NCAPH Proteins
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NCAPH 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000796condensin complex IDA11136719
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0015630microtubule cytoskeleton IDA--

    NCAPH for ontologies           About GeneDecksing



    NCAPH Antibody Products: 
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    Assay Products for NCAPH: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022816 Condensin_barren_su2

    Graphical View of Domain Structure for InterPro Entry Q15003

    ProtoNet protein and cluster: Q15003

    1 Blocks protein domain: IPB008418 Barren

    UniProtKB/Swiss-Prot: CND2_HUMAN, Q15003
    Similarity: Belongs to the CND2 (condensin subunit 2) family


    NCAPH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CND2_HUMAN, Q15003
    Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
    into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
    relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
    presence of type II topoisomerases

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17268547
         
    NCAPH for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ncaph):
     immune system  mortality/aging  vision/eye 

    NCAPH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NCAPH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCAPH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCAPH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCAPH 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAPH:
    hsa-miR-493* hsa-miR-3924 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidNCAPH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: NCAPH (NM_015341)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCAPH About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase0.93
    4Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00
    5Condensation of Prometaphase Chromosomes
    Condensation of Prometaphase Chromosomes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NCAPH
        Cell cycle Chromosome condensation in prometaphase


    1 GeneGo (Thomson Reuters) Pathway for NCAPH
        Cell cycle Chromosome condensation in prometaphase

    1 BioSystems Pathway for NCAPH
        Aurora B signaling

    5/6        Reactome Pathways for NCAPH (see all 6)
        Mitotic Prometaphase
    Cell Cycle
    Condensation of Prometaphase Chromosomes
    M Phase
    Mitotic M-M/G1 phases



    NCAPH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCAPH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/790 Interacting proteins for NCAPH (Q150031, 2, 3 ENSP000002404234) via UniProtKB, MINT, STRING, and/or I2D (see all 790)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAPD2Q150212, 3, ENSP000003250174MINT-7945693 MINT-4330136 MINT-4330190 MINT-4329880 MINT-4330147 MINT-7947479 I2D: score=1 STRING: ENSP00000325017
    SMC4Q9NTJ32, 3, ENSP000003413824MINT-7945693 MINT-4330064 MINT-7947479 I2D: score=1 STRING: ENSP00000341382
    CAPGP401212, 3, ENSP000002638674MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000263867
    DDX3XO005711, 2EBI-1046410,EBI-353779 MINT-7945693 MINT-7947479
    AURKAO149652, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis ----
    GO:0007076mitotic chromosome condensation IDA11136719
    GO:0030261chromosome condensation ----
    GO:0051301cell division IEA--

    NCAPH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCAPH (CND2)

    Search CenterWatch for drugs/clinical trials and news about NCAPH / CND2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCAPH gene (4 alternative transcripts): 
    NM_001281710.1  NM_001281711.1  NM_001281712.1  NM_015341.4  

    Unigene Cluster for NCAPH:

    Non-SMC condensin I complex, subunit H
    Hs.308045  [show with all ESTs]
    Unigene Representative Sequence: NM_015341
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240423(uc010fhv.1 uc002svz.1 uc010yum.1 uc010yun.1)
    ENST00000427946 ENST00000477409(uc010fhu.1) ENST00000435975 ENST00000456906
    ENST00000455200 ENST00000435349
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAPH:
    hsa-miR-493* hsa-miR-3924 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidNCAPH 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NCAPH (NM_015341)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAPH
    Sirion Biotech Customized lentivirus for stable overexpression of NCAPH 
                         Customized lentivirus expression plasmids for stable overexpression of NCAPH 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCAPH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCAPH

    Additional mRNA sequence: 

    AK291053.1 AK299248.1 AK303725.1 AK308050.1 AK310649.1 BC024211.2 D38553.1 

    8 DOTS entries:

    DT.214623  DT.92432537  DT.86853974  DT.95345110  DT.100783319  DT.100783313  DT.95070228  DT.97822656 

    24/207 AceView cDNA sequences (see all 207):

    BQ685302 AA713690 BU169085 BQ685570 AI268885 BQ187495 BF513300 CB113163 
    BU163090 BQ901040 CR610329 BQ685467 BU163449 CA423478 BE877319 BU174522 
    BU150166 BU163407 BQ689854 BE208061 BQ876685 BQ689672 BM468688 BQ687347 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NCAPH (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                    -                                                                                                                                       
    SP2:                    -     -                 -     -     -     -     -     -     -     -     -                                                               
    SP3:                    -     -                                                                                                                                 
    SP4:                    -     -     -                                                                                                                           
    SP5:                                                                                                                                            -               

    ExUns: 16 ^ 17 ^ 18a · 18b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for NCAPH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCAPH expression in normal human tissues (normalized intensities)      NCAPH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCAPH Expression
    About this image


    NCAPH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Heart (Cardiovascular System)
             heart muscle ; myocytes   
     
     Epidermis (Integumentary System)
             vulva/anal skin ; epidermal cells   
     
     Tonsil (Hematopoietic System)
             tonsil ; germinal center cells   

    See NCAPH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCAPH

    SOURCE GeneReport for Unigene cluster: Hs.308045

    UniProtKB/Swiss-Prot: CND2_HUMAN, Q15003
    Tissue specificity: Widely expressed at low level. Expressed in proliferating cells

        SABiosciences Custom PCR Arrays for NCAPH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCAPH gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncaph1 , 5 non-SMC condensin I complex, subunit H1, 5 81.74(n)1
    79.81(a)1
      2 (61.76 cM)5
    2153871  NM_144818.31  NP_659067.21 
     1271038095 
    chicken
    (Gallus gallus)
    Aves NCAPH6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    22(2937124-2946362)
    lizard
    (Anolis carolinensis)
    Reptilia NCAPH6
    non-SMC condensin I complex, subunit H
    56(a)
    1 ↔ 1
    GL343608.1(39752-69149)
    African clawed frog
    (Xenopus laevis)
    Amphibia brrn1-prov2 barren homolog (Drosophila) 77.5(n)    BC056095.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc69h062 Transcribed sequence with weak similarity to protein more 76.95(n)    BM265158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta barr6
    barren
    22(a)
    1 ↔ 1
    2L(20058163-20060975)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BRN1(YBL097W)4
    BRN11
    Subunit of the condensin complex; required for chromosome more4
    Brn1p1
    41.75(n)1
    25.88(a)1
      2(40831-43095)4
    8521801, 4  NP_009455.31  NP_009455.24 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G325901 condensin complex subunit 2 45.83(n)
    32.06(a)
      817819  NM_128818.2  NP_180818.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g05328001 hypothetical protein 45.75(n)
    36.84(a)
      4327806  NM_001049785.1  NP_001043250.2 


    ENSEMBL Gene Tree for NCAPH (if available)
    TreeFam Gene Tree for NCAPH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/817 SNPs in NCAPH are shown (see all 817)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808865751,2
    --96999576(+) CCTTCC/TAGGAC 1 -- us2k10--------
    rs119034611,2
    C,F,A,H--96999580(+) CCAGGA/GCCTTG 1 -- us2k122Minor allele frequency- G:0.33NS EA NA WA CSA 2351
    rs1491886031,2
    --96999595(+) ACGCTC/TAGAGG 1 -- us2k10--------
    rs1143880141,2
    F--96999658(+) GGGGAC/TAAGTG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1149335041,2
    C,F--96999713(+) CTGAGG/CGGGGG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1872168851,2
    --96999878(+) CTTGGG/TTGGCT 1 -- us2k10--------
    rs1920373021,2
    --96999915(+) GTGTCA/GACCTG 1 -- us2k10--------
    rs1423811161,2
    --97000017(+) GGTTTA/TCAGCC 1 -- us2k10--------
    rs1841675281,2
    --97000227(+) ACTTGC/GGAGGT 1 -- us2k10--------
    rs1513263161,2
    C--97000262(+) TGCCAC/TTGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCAPH (97001484 - 97041274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NCAPH:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    nsv508155CNV Loss20534489
    nsv819311CNV Loss19587683
    nsv874677CNV Loss21882294
    nsv874679CNV Gain21882294
    nsv834305CNV Gain17160897
    esv5003CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NCAPH for disorders           About MalaCards
    OMIM gene information: 602332    OMIM disorders: --


    NCAPH for disorders           About GeneDecksing


    Export disorders for NCAPH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCAPH gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with NCAPH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Cell cycle-dependent expression and nucleolar localization of hCAP- H. (PubMed id 11694586)1, 2 Cabello O.A.... Belmont J.W. (2001)
    3. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)1, 2 Kimura K....Hirano T. (2001)
    4. Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. (PubMed id 9417923)1, 3 Cabello O.A....Belmont J.W. (1997)
    5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    6. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23397 HGNC: 1112 AceView: BRRN1 Ensembl:ENSG00000121152 euGenes: HUgn23397
    ECgene: NCAPH H-InvDB: NCAPH

    (According to HUGE)
    About This Section
    HUGE: KIAA0074

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCAPH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCAPH gene:
    Search GeneIP for patents involving NCAPH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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