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Aliases for NCAPG2 Gene

Aliases for NCAPG2 Gene

  • Non-SMC Condensin II Complex Subunit G2 2 3 4 5
  • Leucine Zipper Protein 5 2 3 4
  • Chromosome-Associated Protein G2 3 4
  • HCAP-G2 3 4
  • CAP-G2 3 4
  • LUZP5 3 4
  • Non-SMC Condensin II Complex, Subunit G2 2
  • Condensin-2 Complex Subunit G2 3
  • More Than Blood Homolog 3
  • CAPG2 3
  • MTB 3

External Ids for NCAPG2 Gene

Previous HGNC Symbols for NCAPG2 Gene

  • LUZP5

Previous GeneCards Identifiers for NCAPG2 Gene

  • GC07M158116
  • GC07M158424
  • GC07M152163

Summaries for NCAPG2 Gene

Entrez Gene Summary for NCAPG2 Gene

  • This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for NCAPG2 Gene

NCAPG2 (Non-SMC Condensin II Complex Subunit G2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Mitotic Prophase. GO annotations related to this gene include binding and methylated histone binding.

UniProtKB/Swiss-Prot for NCAPG2 Gene

  • Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Wiki entry for NCAPG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPG2 Gene

Genomics for NCAPG2 Gene

Regulatory Elements for NCAPG2 Gene

Enhancers for NCAPG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G158739 1.2 Ensembl ENCODE 19.5 -36.1 -36086 2.7 TCF12 ZNF766 CBX5 GATA2 FOS KDM4B JUNB NCOA1 ZNF592 MBD2 ESYT2 NCAPG2 GC07P158720 PIR61971
GH07G158782 1.4 Ensembl ENCODE dbSUPER 11.3 -79.0 -78978 3.0 ATF1 ZNF493 SIN3A RAD21 ZNF335 ZNF138 ZNF354C FOS ZNF202 ZNF680 ESYT2 NCAPG2 WDR60 PIR61971 GC07P158720
GH07G158778 1.2 Ensembl ENCODE dbSUPER 11.4 -74.8 -74830 1.4 CTCF LEF1 ESRRA NFIB NFIA RAD21 ZKSCAN1 ZNF121 ZNF664 MEF2D ESYT2 NCAPG2 WDR60 PIR61971 GC07P158720
GH07G158809 2 FANTOM5 Ensembl ENCODE dbSUPER 6.6 -112.9 -112926 16.6 DMAP1 FEZF1 YY1 ZNF143 ZNF263 TBX21 SSRP1 ZNF610 RCOR2 NBN ESYT2 WDR60 NCAPG2 PIR38782
GH07G158785 1.1 ENCODE dbSUPER 11.3 -81.2 -81244 1.1 ZNF493 ZFP64 ZNF138 ZNF354C ZNF202 ZNF680 ZNF426 REST ZNF623 ZNF518A ESYT2 NCAPG2 PIR61971 GC07P158720
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCAPG2 on UCSC Golden Path with GeneCards custom track

Promoters for NCAPG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220309 -269 1401 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for NCAPG2 Gene

Chromosome:
7
Start:
158,631,169 bp from pter
End:
158,704,831 bp from pter
Size:
73,663 bases
Orientation:
Minus strand

Genomic View for NCAPG2 Gene

Genes around NCAPG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPG2 Gene

Proteins for NCAPG2 Gene

  • Protein details for NCAPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XI2-CNDG2_HUMAN
    Recommended name:
    Condensin-2 complex subunit G2
    Protein Accession:
    Q86XI2
    Secondary Accessions:
    • A4D228
    • Q7Z3J9
    • Q8WUG8
    • Q9BRX6
    • Q9H8S2
    • Q9H9K6

    Protein attributes for NCAPG2 Gene

    Size:
    1143 amino acids
    Molecular mass:
    130960 Da
    Quaternary structure:
    • Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.
    SequenceCaution:
    • Sequence=AAH20560.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14219.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NCAPG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAPG2 Gene

Post-translational modifications for NCAPG2 Gene

  • Ubiquitination at posLast=4545, posLast=139139, Lys178, Lys332, Lys402, Lys406, Lys422, Lys451, Lys474, Lys496, Lys650, posLast=660660, posLast=796796, Lys1025, and Lys1054
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NCAPG2 Gene

Domains & Families for NCAPG2 Gene

Gene Families for NCAPG2 Gene

Protein Domains for NCAPG2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCAPG2: view

No data available for UniProtKB/Swiss-Prot for NCAPG2 Gene

Function for NCAPG2 Gene

Molecular function for NCAPG2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Ontology (GO) - Molecular Function for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035064 methylated histone binding IDA 20622854
genes like me logo Genes that share ontologies with NCAPG2: view
genes like me logo Genes that share phenotypes with NCAPG2: view

Animal Models for NCAPG2 Gene

MGI Knock Outs for NCAPG2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAPG2 Gene

Localization for NCAPG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAPG2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with NCAPG2: view

Pathways & Interactions for NCAPG2 Gene

genes like me logo Genes that share pathways with NCAPG2: view

Pathways by source for NCAPG2 Gene

1 GeneGo (Thomson Reuters) pathway for NCAPG2 Gene

Gene Ontology (GO) - Biological Process for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001833 inner cell mass cell proliferation IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0030261 chromosome condensation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPG2: view

No data available for SIGNOR curated interactions for NCAPG2 Gene

Transcripts for NCAPG2 Gene

Unigene Clusters for NCAPG2 Gene

Non-SMC condensin II complex, subunit G2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NCAPG2 Gene

GeneLoc Exon Structure for
NCAPG2
ECgene alternative splicing isoforms for
NCAPG2

Expression for NCAPG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCAPG2 Gene

Protein differential expression in normal tissues from HIPED for NCAPG2 Gene

This gene is overexpressed in Ovary (55.9) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCAPG2 Gene



Protein tissue co-expression partners for NCAPG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCAPG2 Gene:

NCAPG2

SOURCE GeneReport for Unigene cluster for NCAPG2 Gene:

Hs.18616
genes like me logo Genes that share expression patterns with NCAPG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAPG2 Gene

Orthologs for NCAPG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAPG2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NCAPG2 35 34
  • 85.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapg2 34 16 35
  • 83.11 (n)
rat
(Rattus norvegicus)
Mammalia Ncapg2 34
  • 82.41 (n)
cow
(Bos Taurus)
Mammalia NCAPG2 34 35
  • 81.32 (n)
oppossum
(Monodelphis domestica)
Mammalia NCAPG2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPG2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859557 34
  • 67.37 (n)
NCAPG2 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPG2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapg2 34
  • 64.74 (n)
zebrafish
(Danio rerio)
Actinopterygii ncapg2 34 35
  • 54.5 (n)
worm
(Caenorhabditis elegans)
Secernentea capg-2 35
  • 19 (a)
OneToOne
Species where no ortholog for NCAPG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPG2 Gene

ENSEMBL:
Gene Tree for NCAPG2 (if available)
TreeFam:
Gene Tree for NCAPG2 (if available)

Paralogs for NCAPG2 Gene

No data available for Paralogs for NCAPG2 Gene

Variants for NCAPG2 Gene

Sequence variations from dbSNP and Humsavar for NCAPG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs199564693 Uncertain significance 158,656,399(+) TGTCA(C/T)GGATC nc-transcript-variant, reference, missense
rs199598836 Uncertain significance 158,646,554(+) TTCTA(C/T)GTCAG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1000006760 -- 158,651,805(+) ACATA(A/G)GACAG intron-variant
rs1000007062 -- 158,695,744(+) GGCCA(A/C/T)AGGAC intron-variant
rs1000116919 -- 158,703,165(+) CCTAA(C/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPG2 Gene

Variant ID Type Subtype PubMed ID
dgv1168e201 CNV deletion 23290073
dgv1169e201 CNV deletion 23290073
dgv11795n54 CNV gain+loss 21841781
dgv11796n54 CNV gain 21841781
dgv11797n54 CNV gain+loss 21841781
dgv11798n54 CNV loss 21841781
dgv6772n100 CNV gain 25217958
dgv6773n100 CNV gain 25217958
dgv6774n100 CNV gain 25217958
dgv6775n100 CNV gain 25217958
esv1002284 CNV insertion 20482838
esv1010957 CNV insertion 20482838
esv1218051 CNV insertion 17803354
esv2229751 CNV deletion 18987734
esv22916 CNV gain+loss 19812545
esv2560438 CNV insertion 19546169
esv25694 CNV loss 19812545
esv2736017 CNV deletion 23290073
esv2736018 CNV deletion 23290073
esv2736019 CNV deletion 23290073
esv2736021 CNV deletion 23290073
esv2736026 CNV deletion 23290073
esv2736029 CNV deletion 23290073
esv275466 CNV gain+loss 21479260
esv2764036 CNV gain+loss 21179565
esv3366900 CNV insertion 20981092
esv3615729 CNV gain 21293372
esv3615736 CNV gain 21293372
esv3891247 CNV gain 25118596
esv993130 CNV deletion 20482838
nsv1023304 CNV gain 25217958
nsv1032050 CNV gain 25217958
nsv1032713 CNV loss 25217958
nsv1077743 CNV insertion 25765185
nsv1117474 CNV tandem duplication 24896259
nsv1125935 CNV tandem duplication 24896259
nsv1149050 CNV insertion 26484159
nsv438013 CNV loss 16468122
nsv507432 OTHER sequence alteration 20534489
nsv609363 CNV loss 21841781
nsv609364 CNV loss 21841781
nsv609365 CNV loss 21841781
nsv609374 CNV gain 21841781
nsv609376 CNV loss 21841781
nsv951681 CNV deletion 24416366

Variation tolerance for NCAPG2 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAPG2 Gene

Human Gene Mutation Database (HGMD)
NCAPG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAPG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPG2 Gene

Disorders for NCAPG2 Gene

Relevant External Links for NCAPG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAPG2

No disorders were found for NCAPG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAPG2 Gene

Publications for NCAPG2 Gene

  1. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. (PMID: 14532007) Ono T. … Hirano T. (Cell 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 64

Products for NCAPG2 Gene

Sources for NCAPG2 Gene

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