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Aliases for NCAPG2 Gene

Aliases for NCAPG2 Gene

  • Non-SMC Condensin II Complex, Subunit G2 2 3
  • Leucine Zipper Protein 5 2 3 4
  • Chromosome-Associated Protein G2 3 4
  • HCAP-G2 3 4
  • CAP-G2 3 4
  • LUZP5 3 4
  • Non-SMC Condensin II Complex Subunit G2 4
  • More Than Blood Homolog 3
  • CAPG2 3
  • MTB 3

External Ids for NCAPG2 Gene

Previous HGNC Symbols for NCAPG2 Gene

  • LUZP5

Previous GeneCards Identifiers for NCAPG2 Gene

  • GC07M158116
  • GC07M158424
  • GC07M152163

Summaries for NCAPG2 Gene

Entrez Gene Summary for NCAPG2 Gene

  • This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for NCAPG2 Gene

NCAPG2 (Non-SMC Condensin II Complex, Subunit G2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prophase. GO annotations related to this gene include binding and methylated histone binding.

UniProtKB/Swiss-Prot for NCAPG2 Gene

  • Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Wiki entry for NCAPG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPG2 Gene

Genomics for NCAPG2 Gene

Regulatory Elements for NCAPG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCAPG2 Gene

Chromosome:
7
Start:
158,631,169 bp from pter
End:
158,704,831 bp from pter
Size:
73,663 bases
Orientation:
Minus strand

Genomic View for NCAPG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPG2 Gene

Proteins for NCAPG2 Gene

  • Protein details for NCAPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XI2-CNDG2_HUMAN
    Recommended name:
    Condensin-2 complex subunit G2
    Protein Accession:
    Q86XI2
    Secondary Accessions:
    • A4D228
    • Q7Z3J9
    • Q8WUG8
    • Q9BRX6
    • Q9H8S2
    • Q9H9K6

    Protein attributes for NCAPG2 Gene

    Size:
    1143 amino acids
    Molecular mass:
    130960 Da
    Quaternary structure:
    • Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.
    SequenceCaution:
    • Sequence=AAH20560.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14219.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NCAPG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAPG2 Gene

Proteomics data for NCAPG2 Gene at MOPED

Post-translational modifications for NCAPG2 Gene

  • Ubiquitination at Lys 45, Lys 139, Lys 178, Lys 332, Lys 402, Lys 406, Lys 422, Lys 451, Lys 474, Lys 496, Lys 650, Lys 660, Lys 796, Lys 1025, and Lys 1054
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPG2 Gene

No data available for DME Specific Peptides for NCAPG2 Gene

Domains & Families for NCAPG2 Gene

Protein Domains for NCAPG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86XI2

UniProtKB/Swiss-Prot:

CNDG2_HUMAN :
  • Contains 1 HEAT repeat.
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with NCAPG2: view

No data available for Gene Families for NCAPG2 Gene

Function for NCAPG2 Gene

Molecular function for NCAPG2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Ontology (GO) - Molecular Function for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17268547
GO:0035064 methylated histone binding IDA 20622854
genes like me logo Genes that share ontologies with NCAPG2: view
genes like me logo Genes that share phenotypes with NCAPG2: view

Animal Models for NCAPG2 Gene

MGI Knock Outs for NCAPG2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NCAPG2 Gene

Localization for NCAPG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPG2 Gene COMPARTMENTS Subcellular localization image for NCAPG2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NCAPG2: view

Pathways & Interactions for NCAPG2 Gene

genes like me logo Genes that share pathways with NCAPG2: view

Pathways by source for NCAPG2 Gene

1 GeneGo (Thomson Reuters) pathway for NCAPG2 Gene

Gene Ontology (GO) - Biological Process for NCAPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0030261 chromosome condensation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPG2: view

No data available for SIGNOR curated interactions for NCAPG2 Gene

Drugs & Compounds for NCAPG2 Gene

No Compound Related Data Available

Transcripts for NCAPG2 Gene

Unigene Clusters for NCAPG2 Gene

Non-SMC condensin II complex, subunit G2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NCAPG2 Gene

GeneLoc Exon Structure for
NCAPG2
ECgene alternative splicing isoforms for
NCAPG2

Expression for NCAPG2 Gene

mRNA expression in normal human tissues for NCAPG2 Gene

Protein differential expression in normal tissues from HIPED for NCAPG2 Gene

This gene is overexpressed in Ovary (55.9) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPG2 Gene



SOURCE GeneReport for Unigene cluster for NCAPG2 Gene Hs.18616

genes like me logo Genes that share expression patterns with NCAPG2: view

Protein tissue co-expression partners for NCAPG2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAPG2 Gene

Orthologs for NCAPG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAPG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAPG2 35
  • 81.32 (n)
  • 81.67 (a)
NCAPG2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPG2 35
  • 85.82 (n)
  • 87.26 (a)
NCAPG2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapg2 35
  • 83.11 (n)
  • 81.27 (a)
Ncapg2 16
Ncapg2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncapg2 35
  • 82.41 (n)
  • 81.88 (a)
oppossum
(Monodelphis domestica)
Mammalia NCAPG2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPG2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859557 35
  • 67.37 (n)
  • 62.01 (a)
NCAPG2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPG2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapg2 35
  • 64.74 (n)
  • 60.96 (a)
zebrafish
(Danio rerio)
Actinopterygii ncapg2 35
  • 54.5 (n)
  • 46.86 (a)
ncapg2 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea capg-2 36
  • 19 (a)
OneToOne
Species with no ortholog for NCAPG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPG2 Gene

ENSEMBL:
Gene Tree for NCAPG2 (if available)
TreeFam:
Gene Tree for NCAPG2 (if available)

Paralogs for NCAPG2 Gene

No data available for Paralogs for NCAPG2 Gene

Variants for NCAPG2 Gene

Sequence variations from dbSNP and Humsavar for NCAPG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs73516483 -- 158,682,956(+) ATTGG(A/T)ATTTA intron-variant
rs73516492 -- 158,688,652(+) CTCAT(C/G)TGTTC intron-variant
rs73730470 -- 158,630,972(+) CACTC(A/C)GGGAG downstream-variant-500B
rs73729915 -- 158,705,437(+) GGTCA(C/G)CTGCC upstream-variant-2KB
rs73729914 -- 158,701,469(+) TAAAA(G/T)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPG2 Gene

Variant ID Type Subtype PubMed ID
dgv7578n71 CNV Gain 21882294
nsv889644 CNV Gain 21882294
esv1002284 CNV Insertion 20482838
nsv438013 CNV Loss 16468122
esv275466 CNV Gain+Loss 21479260
esv2736017 CNV Deletion 23290073
esv2736018 CNV Deletion 23290073
esv2560438 CNV Insertion 19546169
esv1010957 CNV Insertion 20482838
nsv507432 CNV Insertion 20534489
esv2736019 CNV Deletion 23290073
dgv1216e201 CNV Deletion 23290073
esv2229751 CNV Deletion 18987734
esv2736021 CNV Deletion 23290073
dgv1217e201 CNV Deletion 23290073
esv22916 CNV Gain+Loss 19812545
esv1218051 CNV Insertion 17803354
esv2736026 CNV Deletion 23290073
esv993130 CNV Deletion 20482838
esv25694 CNV Loss 19812545
esv2736029 CNV Deletion 23290073

Variation tolerance for NCAPG2 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAPG2 Gene

HapMap Linkage Disequilibrium report
NCAPG2
Human Gene Mutation Database (HGMD)
NCAPG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPG2 Gene

Disorders for NCAPG2 Gene

Relevant External Links for NCAPG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAPG2
genes like me logo Genes that share disorders with NCAPG2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAPG2 Gene

Publications for NCAPG2 Gene

  1. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. (PMID: 14532007) Ono T. … Hirano T. (Cell 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for NCAPG2 Gene

Sources for NCAPG2 Gene

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