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NCAPG Gene

protein-coding   GIFtS: 64
GCID: GC04P017812

Non-SMC Condensin I Complex, Subunit G

  See NCAPG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Non-SMC Condensin I Complex, Subunit G1 2     CHCG2
CAPG2 3 5     NY-MEL-32
Chromosome Condensation Protein G1 2     YCG12
Chromosome-Associated Protein G2 3     Condensin Complex Subunit 32
Condensin Subunit CAP-G2 3     NYMEL33
Melanoma Antigen NY-MEL-32 3     hCAP-G3
XCAP-G Homolog2 3     Non-SMC Condensin I Complex Subunit G3

External Ids:    HGNC: 243041   Entrez Gene: 641512   Ensembl: ENSG000001098057   OMIM: 6062805   UniProtKB: Q9BPX33   

Export aliases for NCAPG gene to outside databases

Previous GC identifers: GC04P017421 GC04P017167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCAPG Gene:
This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization
of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin
complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for NCAPG Gene:
NCAPG (non-SMC condensin I complex, subunit G) is a protein-coding gene. Diseases associated with NCAPG include croup.

UniProtKB/Swiss-Prot: CND3_HUMAN, Q9BPX3
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
presence of type II topoisomerases

Gene Wiki entry for NCAPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCAPG gene promoter:
         HSF1 (long)   Tal-1beta   GATA-2   GATA-1   E47   FOXL1   HSF1short   Pax-4a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAPG promoter sequence
   Search Chromatin IP Primers for NCAPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.33   Ensembl cytogenetic band:  4p15.31   HGNC cytogenetic band: 4p15.32

NCAPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAPG gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P017812:  view genomic region     (about GC identifiers)

Start:
17,812,525 bp from pter      End:
17,846,488 bp from pter
Size:
33,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CND3_HUMAN, Q9BPX3 (See protein sequence)
Recommended Name: Condensin complex subunit 3  
Size: 1015 amino acids; 114334 Da
Subunit: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC
subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG
Miscellaneous: Overexpressed in some cancer lines and some tumor cells
Sequence caution: Sequence=AAH00827.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55165.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3MJE0 Q96SV9 Q9BUR3 Q9BVY1 Q9H914 Q9H9Z6 Q9HBI9

Explore the universe of human proteins at neXtProt for NCAPG: NX_Q9BPX3

Explore proteomics data for NCAPG at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin
    complex and is required for chromosome condensation (By similarity)1
  • Ubiquitination2 at Lys11, Lys235, Lys522, Lys717, Lys852
  • Modification sites at PhosphoSitePlus

  • See NCAPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071741.2  
    ENSEMBL proteins: 
     ENSP00000251496   ENSP00000423042   ENSP00000425625  
    Reactome Protein details: Q9BPX3

    NCAPG Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for NCAPG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR027165 CND3
     IPR025977 Cnd3_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BPX3

    ProtoNet protein and cluster: Q9BPX3

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CND3_HUMAN, Q9BPX3
    Similarity: Belongs to the CND3 (condensin subunit 3) family
    Similarity: Contains 10 HEAT repeats


    Find genes that share domains with NCAPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CND3_HUMAN, Q9BPX3
    Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
    into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
    relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
    presence of type II topoisomerases

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12138188
         
    Find genes that share ontologies with NCAPG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCAPG:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
    Products:
        
    miRTarBase miRNAs that target NCAPG:
    hsa-mir-155-5p (MIRT020693), hsa-mir-193b-3p (MIRT016370), hsa-mir-16-5p (MIRT031595), hsa-mir-21-5p (MIRT000171), hsa-mir-421 (MIRT039450), hsa-mir-1 (MIRT023728), hsa-mir-34a-5p (MIRT025382)

    Block miRNA regulation of human, mouse, rat NCAPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAPG (see all 10):
    hsa-miR-548d-3p hsa-miR-1258 hsa-miR-944 hsa-miR-3907 hsa-miR-105 hsa-miR-182* hsa-miR-659 hsa-miR-3168
    SwitchGear 3'UTR luciferase reporter plasmidNCAPG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NCAPG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NCAPG (NM_017760)
    Sino Biological Human cDNA Clone for NCAPG
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CND3_HUMAN, Q9BPX3: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin
    complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation
    of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the
    condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the
    complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome
    condensation. Dissociation from chromosomes is observed in late telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome ----
    GO:0000796condensin complex IDA11136719
    GO:0005634nucleus NAS10910072
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with NCAPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCAPG About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    3Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase
    4Aurora B signaling
    Aurora B signaling


    Find genes that share SuperPaths with NCAPG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NCAPG
        Cell cycle Chromosome condensation in prometaphase

    1 BioSystems Pathway for NCAPG
        Aurora B signaling


    1 Reactome Pathway for NCAPG
        Condensation of Prometaphase Chromosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCAPG
    Interactions:

        Search GeneGlobe Interaction Network for NCAPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCAPG (Q9BPX31, 2, 3 ENSP000002514964) via UniProtKB, MINT, STRING, and/or I2D (see all 618)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAPD2Q150211, 2, 3, ENSP000003250174EBI-970214,EBI-1044041 MINT-7945693 MINT-4329892 MINT-4330111 I2D: score=1 STRING: ENSP00000325017
    POLD1P283402, 3MINT-7945693 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7945693 I2D: score=1 
    NCAPHQ150031, 2, 3, ENSP000002404234EBI-970214,EBI-1046410 MINT-4330165 MINT-7945693 MINT-4330125 I2D: score=1 STRING: ENSP00000240423
    SMC2O953472, 3, ENSP000002863984MINT-7945693 MINT-4329981 I2D: score=1 STRING: ENSP00000286398
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007076mitotic chromosome condensation NAS10910072

    Find genes that share ontologies with NCAPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCAPG (CND3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCAPG gene: 
    NM_022346.4  

    Unigene Cluster for NCAPG:

    Non-SMC condensin I complex, subunit G
    Hs.567567  [show with all ESTs]
    Unigene Representative Sequence: NM_022346
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251496(uc003gpp.3 uc011bxj.2) ENST00000514176 ENST00000513226
    ENST00000509719 ENST00000510063
    miRNA
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    Block miRNA regulation of human, mouse, rat NCAPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAPG (see all 10):
    hsa-miR-548d-3p hsa-miR-1258 hsa-miR-944 hsa-miR-3907 hsa-miR-105 hsa-miR-182* hsa-miR-659 hsa-miR-3168
    SwitchGear 3'UTR luciferase reporter plasmidNCAPG 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NCAPG (NM_017760)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCAPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAPG
    Primer
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    OriGene qPCR primer pairs and template standards for NCAPG
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NCAPG
      QuantiTect SYBR Green Assays in human, mouse, rat NCAPG
      QuantiFast Probe-based Assays in human, mouse, rat NCAPG

    Additional mRNA sequence: 

    AB013299.1 AF235023.1 AF331796.1 AK022512.1 AK023147.1 AK027511.1 BC000827.1 BC002337.2 
    BC068467.1 BC101476.1 BC143383.1 NR_073124.1 

    11 DOTS entries:

    DT.106739  DT.99947850  DT.427779  DT.100028192  DT.100818993  DT.121231908  DT.121231951  DT.121231954 
    DT.75195922  DT.95173678  DT.102827054 

    Selected AceView cDNA sequences (see all 201):

    BF795312 BM873985 AA640134 BM761262 BQ951725 AI039522 AB013299 BE278549 
    BM874416 CA423579 BM767268 AA496777 AF331796 BM987728 BM756908 CA430279 
    BQ222962 CA335931 AU119856 BI253340 AA705810 BQ427449 AW468663 AI954042 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:                          -                 -                       -                                                                       -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NCAPG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCAPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTCCAGA
    NCAPG Expression
    About this image


    NCAPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Thymus (Hematopoietic System)
             Thymus
    NCAPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCAPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567567

    UniProtKB/Swiss-Prot: CND3_HUMAN, Q9BPX3
    Tissue specificity: Highly expressed in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NCAPG gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncapg1 , 5 non-SMC condensin I complex, subunit G1, 5 86.45(n)1
    83.07(a)1
      5 (25.23 cM)5
    543921  NM_019438.11  NP_062311.11 
     456699225 
    chicken
    (Gallus gallus)
    Aves NCAPG1 non-SMC condensin I complex, subunit G 70.79(n)
    65.25(a)
      422822  XM_420769.4  XP_420769.3 
    lizard
    (Anolis carolinensis)
    Reptilia NCAPG6
    non-SMC condensin I complex, subunit G
    60(a)
    1 ↔ 1
    5(76899520-76934477)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980882 chromosome condensation protein XCAP-G 73.93(n)    BC041184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncapg1 non-SMC condensin I complex, subunit G 59.07(n)
    53.2(a)
      492707  NM_001256205.1  NP_001243134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cap-G1 Cap-G 40.69(n)
    27.55(a)
      36440  NM_001169664.1  NP_001163135.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCG1(YDR325W)4 Subunit of the condensin complex; required for establishment more   --   4(1117126-1120233) 851925  NP_010612.2 


    ENSEMBL Gene Tree for NCAPG (if available)
    TreeFam Gene Tree for NCAPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCAPG gene

    Find genes that share paralogs with NCAPG           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NCAPG
    PGOHUM00000247036 PGOHUM00000235163 PGOHUM00000249496


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCAPG (see all 573)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361254
    A colorectal cancer sample4--see VAR_0361252 M T mis40--------
    rs1854312201,2
    --17814452(+) TTCTTA/GCATTC 2 -- int10--------
    rs1423521321,2
    C--17814459(+) ATTCCA/GAATGT 2 -- int10--------
    rs1504995821,2
    --17814465(+) AATGTA/GTAGAG 2 -- int10--------
    rs1383378801,2
    C,F--17814557(+) AACAGC/TAATGC 3 S syn11Minor allele frequency- T:0.00NA 4548
    rs2007300521,2
    --17814726(+) TTTCAC/TGACTT 3 R * stg10--------
    rs748921521,2
    C,F--17814763(+) AGTGGT/CTAATG 3 /A /V mis11Minor allele frequency- C:0.00NA 4546
    rs1443796481,2
    C,F--17814767(+) GTTAAT/CGGTGT 3 /N syn11Minor allele frequency- C:0.00NA 4548
    rs19116061,2
    H--17814905(+) AAAACC/TTAAGT 2 -- int14Minor allele frequency- T:0.00NS EA 404
    rs2003316291,2
    --17814927(+) AGCTT-/AAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for NCAPG (17812525 - 17846488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NCAPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2645526CNV Deletion19546169
    esv2425595CNV Deletion19546169
    nsv878721CNV Loss21882294
    nsv819190CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NCAPG
    DNA2.0 Custom Variant and Variant Library Synthesis for NCAPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606280    OMIM disorders: --

    1 disease for NCAPG:    
    About MalaCards
    croup

    1 disease from the University of Copenhagen DISEASES database for NCAPG:
    Croup

    Find genes that share disorders with NCAPG           About GenesLikeMe

    Genetic Association Database (GAD): NCAPG
    Human Genome Epidemiology (HuGE) Navigator: NCAPG (1 document)

    Export disorders for NCAPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCAPG gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with NCAPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PubMed id 10910072)1, 2, 3, 9 Jaeger D.... Chen Y.-T. (Cancer Res. 2000)
    2. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)1, 2, 3 Kimura K.... Hirano T. (J. Biol. Chem. 2001)
    3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64151 HGNC: 24304 AceView: HCAP-G Ensembl:ENSG00000109805 euGenes: HUgn64151
    ECgene: NCAPG H-InvDB: NCAPG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NCAPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCAPG gene:
    Search GeneIP for patents involving NCAPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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