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Aliases for NCAPD3 Gene

Aliases for NCAPD3 Gene

  • Non-SMC Condensin II Complex, Subunit D3 2 3
  • CAPD3 3 4 6
  • KIAA0056 4 6
  • HCAP-D3 3 4
  • Non-SMC Condensin II Complex Subunit D3 4
  • Condensin-2 Complex Subunit D3 3
  • CAP-D3 3
  • HHCP-6 3
  • Hcp-6 3

External Ids for NCAPD3 Gene

Previous GeneCards Identifiers for NCAPD3 Gene

  • GC11M133529
  • GC11M134022
  • GC11M129976

Summaries for NCAPD3 Gene

Entrez Gene Summary for NCAPD3 Gene

  • Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NCAPD3 Gene

NCAPD3 (Non-SMC Condensin II Complex, Subunit D3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include methylated histone binding.

UniProtKB/Swiss-Prot for NCAPD3 Gene

  • Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Wiki entry for NCAPD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPD3 Gene

Genomics for NCAPD3 Gene

Regulatory Elements for NCAPD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCAPD3 Gene

Start:
134,150,119 bp from pter
End:
134,225,454 bp from pter
Size:
75,336 bases
Orientation:
Minus strand

Genomic View for NCAPD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPD3 Gene

Proteins for NCAPD3 Gene

  • Protein details for NCAPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42695-CNDD3_HUMAN
    Recommended name:
    Condensin-2 complex subunit D3
    Protein Accession:
    P42695
    Secondary Accessions:
    • A6NFS2
    • Q4KMQ9

    Protein attributes for NCAPD3 Gene

    Size:
    1498 amino acids
    Molecular mass:
    168891 Da
    Quaternary structure:
    • Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.

neXtProt entry for NCAPD3 Gene

Proteomics data for NCAPD3 Gene at MOPED

Post-translational modifications for NCAPD3 Gene

  • Ubiquitination at Lys149, Lys442, Lys559, Lys597, Lys618, Lys743, Lys841, Lys929, and Lys1258
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPD3 Gene

No data available for DME Specific Peptides for NCAPD3 Gene

Domains for NCAPD3 Gene

Protein Domains for NCAPD3 Gene

Suggested Antigen Peptide Sequences for NCAPD3 Gene

Graphical View of Domain Structure for InterPro Entry

P42695

UniProtKB/Swiss-Prot:

CNDD3_HUMAN :
  • P42695
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with NCAPD3: view

No data available for Gene Families for NCAPD3 Gene

Function for NCAPD3 Gene

Molecular function for NCAPD3 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Gene Ontology (GO) - Molecular Function for NCAPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17268547
GO:0035064 methylated histone binding IDA 20622854
genes like me logo Genes that share ontologies with NCAPD3: view

Animal Model Products

CRISPR Products

miRNA for NCAPD3 Gene

miRTarBase miRNAs that target NCAPD3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCAPD3 Gene

Localization for NCAPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPD3 Gene COMPARTMENTS Subcellular localization image for NCAPD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NCAPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000793 condensed chromosome --
GO:0000799 nuclear condensin complex IDA 14532007
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0031618 nuclear pericentric heterochromatin IDA 20551165
genes like me logo Genes that share ontologies with NCAPD3: view

Pathways for NCAPD3 Gene

genes like me logo Genes that share pathways with NCAPD3: view

Pathways by source for NCAPD3 Gene

1 GeneGo (Thomson Reuters) pathway for NCAPD3 Gene

Gene Ontology (GO) - Biological Process for NCAPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007076 mitotic chromosome condensation IDA 14532007
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPD3: view

Transcripts for NCAPD3 Gene

Unigene Clusters for NCAPD3 Gene

Non-SMC condensin II complex, subunit D3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCAPD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39a · 39b
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NCAPD3 Gene

GeneLoc Exon Structure for
NCAPD3
ECgene alternative splicing isoforms for
NCAPD3

Expression for NCAPD3 Gene

mRNA expression in normal human tissues for NCAPD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPD3 Gene

SOURCE GeneReport for Unigene cluster for NCAPD3 Gene Hs.438550

genes like me logo Genes that share expressions with NCAPD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAPD3 Gene

Orthologs for NCAPD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCAPD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPD3 35
  • 99.35 (n)
  • 98.93 (a)
NCAPD3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCAPD3 35
  • 72.81 (n)
  • 66.17 (a)
NCAPD3 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPD3 35
  • 84.22 (n)
  • 83.03 (a)
NCAPD3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapd3 35
  • 79.22 (n)
  • 74.87 (a)
Ncapd3 16
Ncapd3 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCAPD3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ncapd3 35
  • 79.07 (n)
  • 75.79 (a)
chicken
(Gallus gallus)
Aves NCAPD3 35
  • 65.02 (n)
  • 61.46 (a)
NCAPD3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPD3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapd3 35
  • 61.87 (n)
  • 59.74 (a)
zebrafish
(Danio rerio)
Actinopterygii ncapd3 35
  • 56.4 (n)
  • 49.45 (a)
ncapd3 36
  • 46 (a)
OneToOne
zgc55549 35
worm
(Caenorhabditis elegans)
Secernentea hcp-6 36
  • 14 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15890 35
  • 43.51 (n)
  • 28.77 (a)
rice
(Oryza sativa)
Liliopsida Os12g0548100 35
  • 44.47 (n)
  • 30.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for NCAPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPD3 Gene

ENSEMBL:
Gene Tree for NCAPD3 (if available)
TreeFam:
Gene Tree for NCAPD3 (if available)

Paralogs for NCAPD3 Gene

No data available for Paralogs for NCAPD3 Gene

Variants for NCAPD3 Gene

Sequence variations from dbSNP and Humsavar for NCAPD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2603 -- 134,152,634(-) AGGAA(C/T)ACAAC utr-variant-3-prime
rs73731 -- 134,168,643(+) GGGCA(C/T)GGGTG intron-variant
rs94499 -- 134,153,833(-) CTGAT(C/T)CCATG intron-variant
rs581591 -- 134,159,684(+) GCACC(A/G)CGTCC intron-variant
rs589670 -- 134,160,873(-) TGAGC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPD3 Gene

Variant ID Type Subtype PubMed ID
nsv521581 CNV Gain 19592680
esv28602 CNV Loss 19812545
esv2745322 CNV Deletion 23290073
nsv832299 CNV Loss 17160897
nsv898474 CNV Loss 21882294
nsv826147 CNV Gain 20364138

Relevant External Links for NCAPD3 Gene

HapMap Linkage Disequilibrium report
NCAPD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPD3 Gene

Disorders for NCAPD3 Gene

Relevant External Links for NCAPD3

Genetic Association Database (GAD)
NCAPD3
Human Genome Epidemiology (HuGE) Navigator
NCAPD3
genes like me logo Genes that share disorders with NCAPD3: view

No data available for UniProtKB/Swiss-Prot for NCAPD3 Gene

Publications for NCAPD3 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. (PMID: 14532007) Ono T. … Hirano T. (Cell 2003) 2 3 4
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 3 48
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NCAPD3 Gene

Sources for NCAPD3 Gene

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