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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCAPD2 Gene

protein-coding   GIFtS: 59
GCID: GC12P006602

Non-SMC Condensin I Complex, Subunit D2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Non-SMC Condensin I Complex, Subunit D21 2     XCAP-D2 Homolog2 3
Chromosome Condensation Related SMC Associated Protein 11 2     CAP-D22
Chromosome Condensation-Related SMC-Associated Protein 12 3     Condensin Complex Subunit 12
Chromosome-Associated Protein D22 3     CAPD23
CNAP12 3     KIAA01593
hCAP-D22 3     Non-SMC Condensin I Complex Subunit D23

External Ids:    HGNC: 243051   Entrez Gene: 99182   Ensembl: ENSG000000102927   UniProtKB: Q150213   

Export aliases for NCAPD2 gene to outside databases

Previous GC identifer: GC12P006473


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NCAPD2 Gene: 
NCAPD2 (non-SMC condensin I complex, subunit D2) is a protein-coding gene. Diseases associated with NCAPD2 include alzheimer's disease, and breast cancer, and among its related super-pathways are Mitotic M-M/G1 phases and Cell Cycle, Mitotic. GO annotations related to this gene include protein binding and histone binding.

UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain

Gene Wiki entry for NCAPD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCAPD2 gene promoter:
         Elk-1   Pbx1a   CBF-C   GATA-1   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCAPD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NCAPD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCAPD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

NCAPD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAPD2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006602:  view genomic region     (about GC identifiers)

Start:
6,602,522 bp from pter      End:
6,641,132 bp from pter
Size:
38,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021 (See protein sequence)
Recommended Name: Condensin complex subunit 1  
Size: 1401 amino acids; 157182 Da
Subunit: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC
subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and
H3
Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin
complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation
of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the
condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the
complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome
condensation. Dissociation from chromosomes is observed in late telophase
Sequence caution: Sequence=BAA09930.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DUR4 Q8N6U3

Explore the universe of human proteins at neXtProt for NCAPD2: NX_Q15021

Explore proteomics data for NCAPD2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin
    complex and is required for chromosome condensation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15021

  • NCAPD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCAPD2 Protein Expression
    REFSEQ proteins: NP_055680.3  
    ENSEMBL proteins: 
     ENSP00000325017   ENSP00000444377   ENSP00000371895   ENSP00000438495   ENSP00000444417  
    Reactome Protein details: Q15021
    Human Recombinant Protein Products for NCAPD2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCAPD2 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228colocalizes with nuclear chromosome IDA12138188
    GO:0000793condensed chromosome IDA10101332
    GO:0000796condensin complex IDA11136719
    GO:0000797condensin core heterodimer NAS10958694
    GO:0005634nucleus NAS10958694

    NCAPD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR007673 Condensin_cplx_su1
     IPR024324 Condensin_cplx_su1_N
     IPR026971 CND1/NCAPD3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q15021

    ProtoNet protein and cluster: Q15021

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021
    Domain: The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex
    targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal,
    although they are contained within the same region
    Similarity: Belongs to the CND1 (condensin subunit 1) family


    NCAPD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CND1_HUMAN, Q15021
    Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
    into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
    relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
    presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12138188
    GO:0042393histone binding NAS10958694
         
    NCAPD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCAPD2:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidNCAPD2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCAPD2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase0.93
    4Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00
    5Condensation of Prometaphase Chromosomes
    Condensation of Prometaphase Chromosomes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NCAPD2
        Cell cycle Chromosome condensation in prometaphase


    1 GeneGo (Thomson Reuters) Pathway for NCAPD2
        Cell cycle Chromosome condensation in prometaphase

    1 BioSystems Pathway for NCAPD2
        Aurora B signaling

    5/6        Reactome Pathways for NCAPD2 (see all 6)
        Mitotic Prometaphase
    Cell Cycle
    Condensation of Prometaphase Chromosomes
    M Phase
    Mitotic M-M/G1 phases



    NCAPD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCAPD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/806 Interacting proteins for NCAPD2 (Q150212, 3 ENSP000003250174) via UniProtKB, MINT, STRING, and/or I2D (see all 806)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC4Q9NTJ32, 3, ENSP000003413824MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000341382
    DNAJA1P316892, 3MINT-7945693 MINT-7947479 I2D: score=2 
    HSP90AA1P079002, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    TBL1XR1Q9BZK72, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006886intracellular protein transport ----
    GO:0007067mitosis ----
    GO:0007076mitotic chromosome condensation NAS10958694
    GO:0016192vesicle-mediated transport ----

    NCAPD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCAPD2 (CND1)

    Search CenterWatch for drugs/clinical trials and news about NCAPD2 / CND1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCAPD2 gene: 
    NM_014865.3  

    Unigene Cluster for NCAPD2:

    Non-SMC condensin I complex, subunit D2
    Hs.5719  [show with all ESTs]
    Unigene Representative Sequence: D63880
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541399 ENST00000315579(uc001qoo.2 uc010sfd.1) ENST00000539714
    ENST00000536538 ENST00000382457 ENST00000539084 ENST00000545732 ENST00000536090
    ENST00000542472 ENST00000538600 ENST00000542492 ENST00000535804 ENST00000539885
    ENST00000545962(uc009zen.1)

    miRNA
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    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548l hsa-miR-664 hsa-miR-570 hsa-miR-646 hsa-miR-548t
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    Additional mRNA sequence: 

    AK022511.1 AK125155.1 AK128354.1 AK303310.1 BC016913.1 BC028182.1 D63880.1 

    24/25 DOTS entries (see all 25):

    DT.453564  DT.121201162  DT.99943013  DT.101974686  DT.121201133  DT.121201194  DT.92453084  DT.100704747 
    DT.101963266  DT.121201156  DT.121201200  DT.101971673  DT.95360020  DT.95360022  DT.99951776  DT.100652338 
    DT.121201159  DT.121201201  DT.91985744  DT.92443674  DT.95360002  DT.100685553  DT.100685554  DT.121201139 

    7 AceView cDNA sequences:

    AK128354 AK125155 BC016913 BC028182 AK022511 NM_014865 D63880 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                                            -     -                                                                                         -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:        -                                                                                                                                                   
    SP5:                                            -                                                                                                               

    ExUns: 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^
    SP1:                                                                                            -                       -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NCAPD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCAPD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCAPD2 Expression
    About this image


    See NCAPD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCAPD2

    SOURCE GeneReport for Unigene cluster: Hs.5719
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAPD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCAPD2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncapd21 , 5 non-SMC condensin I complex, subunit D21, 5 85.97(n)1
    86.83(a)1
      6 (59.32 cM)5
    682981  NM_146171.11  NP_666283.11 
     1251680075 
    chicken
    (Gallus gallus)
    Aves NCAPD21 non-SMC condensin I complex, subunit D2 64.4(n)
    63.46(a)
      418275  NM_001080862.1  NP_001074331.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCAPD26
    non-SMC condensin I complex, subunit D2
    61(a)
    1 ↔ 1
    GL343381.1(569205-618091)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980802 13S condensin XCAP-D2 subunit 74.01(n)    AF072717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266842 Danio rerio cDNA clone IMAGE3817471, partial cds 72.65(n)    BC055262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAP-D21 CAP-D2 condensin subunit 45.06(n)
    31.68(a)
      43491  NM_143452.2  NP_651709.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-281 Protein DPY-28 38.11(n)
    22.01(a)
      176509  NM_066978.3  NP_499379.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCS4(YLR272C)4
    YCS41
    Subunit of the condensin complex; required for establishment more4
    Ycs4p1
    40.75(n)1
    28.17(a)1
      12(687202-683672)4
    8509771, 4  NP_013374.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G570601 condensin complex subunit 1 43.76(n)
    31.09(a)
      824873  NM_115565.2  NP_191265.2 
    rice
    (Oryza sativa)
    Liliopsida Os.92342 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.43(n)    AK073537.1 


    ENSEMBL Gene Tree for NCAPD2 (if available)
    TreeFam Gene Tree for NCAPD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCAPD2 gene

    NCAPD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NCAPD2
    PGOHUM00000232646


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1020 SNPs in NCAPD2 are shown (see all 1020)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0244214
    ----see VAR_0244212 Q E mis40--------
    rs1846751331,2
    --6604749(+) CCTGTA/TTTTGG 1 -- int10--------
    rs1396702861,2
    --6604796(+) TGGGGA/GCAAAA 1 -- int10--------
    rs1890358181,2
    --6604809(+) CCATAA/TTATAT 1 -- int10--------
    rs1497731661,2
    --6604811(+) ATAATA/GTATAT 1 -- int10--------
    rs1457342861,2
    --6604864(+) CTACTA/GAAACC 1 -- int10--------
    rs1418491401,2
    --6605000(+) GGCTGC/TCTGGA 1 -- int10--------
    rs1471231931,2
    --6605086(+) AAATAC/TAGAGA 1 -- int10--------
    rs1815534391,2
    --6605096(+) ATAATA/GACCAA 1 -- int10--------
    rs79607571,2
    C,F,A,H--6605105(+) AATTCC/ATTTGT 1 -- int129Minor allele frequency- A:0.37NS EA NA WA CSA 2775

    HapMap Linkage Disequilibrium report for NCAPD2 (6602522 - 6641132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NCAPD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745476CNV Deletion23290073
    esv2407117CNV Deletion18987734
    esv2745473CNV Deletion23290073
    esv2745472CNV Deletion23290073
    nsv819436CNV Loss19587683
    nsv8895CNV Gain18304495
    esv34325CNV Gain17911159
    esv34390CNV Gain17911159
    essv12131CNV CNV17122850
    dgv453e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): NCAPD2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NCAPD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NCAPD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NCAPD2:    About MalaCards
    alzheimer's disease    breast cancer


    NCAPD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NCAPD2
    Human Genome Epidemiology (HuGE) Navigator: NCAPD2 (5 documents)

    Export disorders for NCAPD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCAPD2 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with NCAPD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PubMed id 10958694)1, 2, 3, 9 Schmiesing J.A.... Yokomori K. (2000)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469)1, 4 Lee J.H....Mayeux R. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. (PubMed id 12138188)1, 2 Ball A.R. Jr.... Yokomori K. (2002)
    10. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)1, 2 Kimura K....Hirano T. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9918 HGNC: 24305 AceView: CNAP1 Ensembl:ENSG00000010292 euGenes: HUgn9918
    ECgene: NCAPD2 H-InvDB: NCAPD2

    (According to HUGE)
    About This Section
    HUGE: KIAA0159

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCAPD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCAPD2 gene:
    Search GeneIP for patents involving NCAPD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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