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Aliases for NCAPD2 Gene

Aliases for NCAPD2 Gene

  • Non-SMC Condensin I Complex Subunit D2 2 3 4 5
  • Chromosome Condensation-Related SMC-Associated Protein 1 3 4
  • Chromosome-Associated Protein D2 3 4
  • XCAP-D2 Homolog 3 4
  • HCAP-D2 3 4
  • CNAP1 3 4
  • Chromosome Condensation Related SMC Associated Protein 1 2
  • Non-SMC Condensin I Complex, Subunit D2 2
  • Condensin Complex Subunit 1 3
  • KIAA0159 4
  • CAP-D2 3
  • CAPD2 4

External Ids for NCAPD2 Gene

Previous GeneCards Identifiers for NCAPD2 Gene

  • GC12P006473
  • GC12P006602

Summaries for NCAPD2 Gene

GeneCards Summary for NCAPD2 Gene

NCAPD2 (Non-SMC Condensin I Complex Subunit D2) is a Protein Coding gene. Among its related pathways are Aurora B signaling and Mitotic Prometaphase. GO annotations related to this gene include binding and histone binding.

UniProtKB/Swiss-Prot for NCAPD2 Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Gene Wiki entry for NCAPD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPD2 Gene

Genomics for NCAPD2 Gene

Regulatory Elements for NCAPD2 Gene

Enhancers for NCAPD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G006530 1.4 ENCODE dbSUPER 38.7 +43.7 43740 12.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NCAPD2 ENSG00000219410 MRPL51 ENSG00000247853 SPSB2 TAPBPL VAMP1 NOP2 ENSG00000256967 ZNF384
GH12G006546 1.8 FANTOM5 ENCODE dbSUPER 27.1 +58.6 58560 10.3 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000219410 ENSG00000247853 NCAPD2 TAPBPL NOP2 SCARNA12 VAMP1 SPSB2 SCARNA11 CHD4
GH12G006940 1.9 FANTOM5 ENCODE dbSUPER 22.9 +460.3 460303 25.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SPSB2 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 SCARNA12 ENSG00000256967 ATN1 TNFRSF1A SCNN1A
GH12G006468 1.1 ENCODE 32.2 -23.1 -23112 3.1 HDGF HNRNPUL1 PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TAPBPL NCAPD2 ENSG00000219410 ENSG00000247853 MRPL51 VAMP1 SPSB2 SCARNA10 ENSG00000255966 GAPDH
GH12G006213 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -268.6 -268563 23.4 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000219410 CD9 ENSG00000247853 NCAPD2 SPSB2 C1RL-AS1 ENSG00000256967 PLEKHG6 VWF SCARNA12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCAPD2 on UCSC Golden Path with GeneCards custom track

Promoters for NCAPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048314 444 2401 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for NCAPD2 Gene

Chromosome:
12
Start:
6,493,356 bp from pter
End:
6,531,966 bp from pter
Size:
38,611 bases
Orientation:
Plus strand

Genomic View for NCAPD2 Gene

Genes around NCAPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPD2 Gene

Proteins for NCAPD2 Gene

  • Protein details for NCAPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15021-CND1_HUMAN
    Recommended name:
    Condensin complex subunit 1
    Protein Accession:
    Q15021
    Secondary Accessions:
    • D3DUR4
    • Q8N6U3

    Protein attributes for NCAPD2 Gene

    Size:
    1401 amino acids
    Molecular mass:
    157182 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.
    SequenceCaution:
    • Sequence=BAA09930.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NCAPD2 Gene

Post-translational modifications for NCAPD2 Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys35, Lys685, posLast=749749, posLast=763763, Lys855, Lys1065, Lys1110, Lys1209, posLast=12881288, and Lys1301
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPD2 Gene

No data available for DME Specific Peptides for NCAPD2 Gene

Domains & Families for NCAPD2 Gene

Suggested Antigen Peptide Sequences for NCAPD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15021

UniProtKB/Swiss-Prot:

CND1_HUMAN :
  • The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.
  • Belongs to the CND1 (condensin subunit 1) family.
Domain:
  • The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.
Family:
  • Belongs to the CND1 (condensin subunit 1) family.
genes like me logo Genes that share domains with NCAPD2: view

No data available for Gene Families for NCAPD2 Gene

Function for NCAPD2 Gene

Molecular function for NCAPD2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Gene Ontology (GO) - Molecular Function for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 12138188
GO:0042393 histone binding NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view
genes like me logo Genes that share phenotypes with NCAPD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCAPD2 Gene

Localization for NCAPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPD2 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAPD2 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 colocalizes_with nuclear chromosome IDA 12138188
GO:0000779 condensed chromosome, centromeric region IBA --
GO:0000793 condensed chromosome IDA 12138188
GO:0000796 condensin complex IDA 11136719
GO:0000797 condensin core heterodimer NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view

Pathways & Interactions for NCAPD2 Gene

genes like me logo Genes that share pathways with NCAPD2: view

Pathways by source for NCAPD2 Gene

1 BioSystems pathway for NCAPD2 Gene
1 GeneGo (Thomson Reuters) pathway for NCAPD2 Gene

Gene Ontology (GO) - Biological Process for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007076 mitotic chromosome condensation NAS,IEA 10958694
GO:0010032 meiotic chromosome condensation IBA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with NCAPD2: view

No data available for SIGNOR curated interactions for NCAPD2 Gene

Drugs & Compounds for NCAPD2 Gene

No Compound Related Data Available

Transcripts for NCAPD2 Gene

mRNA/cDNA for NCAPD2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCAPD2 Gene

Non-SMC condensin I complex, subunit D2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NCAPD2 Gene

GeneLoc Exon Structure for
NCAPD2
ECgene alternative splicing isoforms for
NCAPD2

Expression for NCAPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCAPD2 Gene

Protein differential expression in normal tissues from HIPED for NCAPD2 Gene

This gene is overexpressed in Bone (43.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCAPD2 Gene



Protein tissue co-expression partners for NCAPD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCAPD2 Gene:

NCAPD2

SOURCE GeneReport for Unigene cluster for NCAPD2 Gene:

Hs.5719

Evidence on tissue expression from TISSUES for NCAPD2 Gene

  • Bone marrow(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with NCAPD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAPD2 Gene

Orthologs for NCAPD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCAPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPD2 35 34
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPD2 34 35
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia NCAPD2 34 35
  • 86.69 (n)
mouse
(Mus musculus)
Mammalia Ncapd2 16 35 34
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Ncapd2 34
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia NCAPD2 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPD2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPD2 35 34
  • 64.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPD2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapd2 34
  • 63.39 (n)
Str.6498 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398080 34
zebrafish
(Danio rerio)
Actinopterygii ncapd2 34 35
  • 56.58 (n)
Dr.26684 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003434 34
  • 45.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CAP-D2 34 35
  • 44.86 (n)
worm
(Caenorhabditis elegans)
Secernentea dpy-28 35
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR273C 34
  • 42.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20119g 34
  • 41.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCS4 34 35 37
  • 41.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57060 34
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os07g0659500 34
  • 46.36 (n)
Os.9234 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09297 34
  • 45.82 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnd1 34
  • 41.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4864 34
Species where no ortholog for NCAPD2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPD2 Gene

ENSEMBL:
Gene Tree for NCAPD2 (if available)
TreeFam:
Gene Tree for NCAPD2 (if available)

Paralogs for NCAPD2 Gene

Pseudogenes.org Pseudogenes for NCAPD2 Gene

genes like me logo Genes that share paralogs with NCAPD2: view

No data available for Paralogs for NCAPD2 Gene

Variants for NCAPD2 Gene

Sequence variations from dbSNP and Humsavar for NCAPD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000011590 -- 6,508,619(+) AGTAA(C/T)TGTGG intron-variant, upstream-variant-2KB
rs1000212226 -- 6,512,870(+) ACAGG(A/G)TTTGC intron-variant
rs1000499384 -- 6,513,067(+) ACGTA(A/G)AGTCA intron-variant
rs1000611634 -- 6,503,864(+) ATCCC(A/C)GCTAC intron-variant
rs1000795760 -- 6,521,252(+) CTCTG(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPD2 Gene

Variant ID Type Subtype PubMed ID
esv2407117 CNV deletion 18987734
esv2745472 CNV deletion 23290073
esv2745473 CNV deletion 23290073
esv2745476 CNV deletion 23290073
esv2759876 CNV gain 17122850
esv34325 CNV gain 17911159
esv34390 CNV gain 17911159
esv3548682 CNV deletion 23714750
nsv1071005 CNV deletion 25765185
nsv1138094 CNV deletion 24896259
nsv557255 CNV loss 21841781
nsv819436 CNV loss 19587683
nsv8895 CNV gain 18304495

Variation tolerance for NCAPD2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAPD2 Gene

Human Gene Mutation Database (HGMD)
NCAPD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPD2 Gene

Disorders for NCAPD2 Gene

Relevant External Links for NCAPD2

Genetic Association Database (GAD)
NCAPD2
Human Genome Epidemiology (HuGE) Navigator
NCAPD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAPD2

No disorders were found for NCAPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAPD2 Gene

Publications for NCAPD2 Gene

  1. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PMID: 10958694) Schmiesing J.A. … Yokomori K. (Mol. Cell. Biol. 2000) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PMID: 18340469) Lee J.H. … Mayeux R. (Neurogenetics 2008) 3 46 64

Products for NCAPD2 Gene

Sources for NCAPD2 Gene

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