Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCAPD2 Gene

Aliases for NCAPD2 Gene

  • Non-SMC Condensin I Complex, Subunit D2 2 3
  • CNAP1 3 4 6
  • Chromosome Condensation Related SMC Associated Protein 1 2 3
  • Chromosome Condensation-Related SMC-Associated Protein 1 3 4
  • Chromosome-Associated Protein D2 3 4
  • XCAP-D2 Homolog 3 4
  • KIAA0159 4 6
  • HCAP-D2 3 4
  • Non-SMC Condensin I Complex Subunit D2 4
  • Condensin Complex Subunit 1 3
  • CAP-D2 3
  • CAPD2 4

External Ids for NCAPD2 Gene

Previous GeneCards Identifiers for NCAPD2 Gene

  • GC12P006473
  • GC12P006602

Summaries for NCAPD2 Gene

GeneCards Summary for NCAPD2 Gene

NCAPD2 (Non-SMC Condensin I Complex, Subunit D2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot for NCAPD2 Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Gene Wiki entry for NCAPD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPD2 Gene

Genomics for NCAPD2 Gene

Regulatory Elements for NCAPD2 Gene

Genomic Location for NCAPD2 Gene

Start:
6,493,356 bp from pter
End:
6,531,966 bp from pter
Size:
38,611 bases
Orientation:
Plus strand

Genomic View for NCAPD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPD2 Gene

Proteins for NCAPD2 Gene

  • Protein details for NCAPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15021-CND1_HUMAN
    Recommended name:
    Condensin complex subunit 1
    Protein Accession:
    Q15021
    Secondary Accessions:
    • D3DUR4
    • Q8N6U3

    Protein attributes for NCAPD2 Gene

    Size:
    1401 amino acids
    Molecular mass:
    157182 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.
    SequenceCaution:
    • Sequence=BAA09930.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NCAPD2 Gene

Proteomics data for NCAPD2 Gene at MOPED

Post-translational modifications for NCAPD2 Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys35, Lys685, Lys749, Lys763, Lys855, Lys1065, Lys1110, Lys1209, Lys1288, and Lys1301
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPD2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NCAPD2 Gene

Domains for NCAPD2 Gene

Protein Domains for NCAPD2 Gene

Suggested Antigen Peptide Sequences for NCAPD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15021

UniProtKB/Swiss-Prot:

CND1_HUMAN :
  • Q15021
Domain:
  • The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region
Family:
  • Belongs to the CND1 (condensin subunit 1) family.
genes like me logo Genes that share domains with NCAPD2: view

No data available for Gene Families for NCAPD2 Gene

Function for NCAPD2 Gene

Molecular function for NCAPD2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.

Gene Ontology (GO) - Molecular Function for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12138188
GO:0042393 histone binding NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view

Phenotypes for NCAPD2 Gene

GenomeRNAi human phenotypes for NCAPD2:
genes like me logo Genes that share phenotypes with NCAPD2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCAPD2 Gene

Localization for NCAPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPD2 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPD2 Gene COMPARTMENTS Subcellular localization image for NCAPD2 gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 colocalizes_with nuclear chromosome IDA 12138188
GO:0000793 condensed chromosome IDA 10101332
GO:0000796 condensin complex IDA 11136719
GO:0000797 condensin core heterodimer NAS 10958694
GO:0005634 nucleus NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view

Pathways for NCAPD2 Gene

genes like me logo Genes that share pathways with NCAPD2: view

Pathways by source for NCAPD2 Gene

1 BioSystems pathway for NCAPD2 Gene
1 GeneGo (Thomson Reuters) pathway for NCAPD2 Gene

Gene Ontology (GO) - Biological Process for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006886 intracellular protein transport --
GO:0007067 mitotic nuclear division --
GO:0007076 mitotic chromosome condensation NAS 10958694
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with NCAPD2: view

Transcripts for NCAPD2 Gene

mRNA/cDNA for NCAPD2 Gene

(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCAPD2 Gene

Non-SMC condensin I complex, subunit D2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NCAPD2 Gene

GeneLoc Exon Structure for
NCAPD2
ECgene alternative splicing isoforms for
NCAPD2

Expression for NCAPD2 Gene

mRNA expression in normal human tissues for NCAPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NCAPD2 Gene

This gene is overexpressed in Bone (43.4) and Pancreas (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPD2 Gene

SOURCE GeneReport for Unigene cluster for NCAPD2 Gene Hs.5719

genes like me logo Genes that share expressions with NCAPD2: view

Expression partners for NCAPD2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAPD2 Gene

Orthologs for NCAPD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCAPD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAPD2 35
  • 86.69 (n)
  • 87.4 (a)
NCAPD2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPD2 35
  • 89.17 (n)
  • 89.98 (a)
NCAPD2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapd2 35
  • 85.95 (n)
  • 86.76 (a)
Ncapd2 16
Ncapd2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCAPD2 35
  • 99.67 (n)
  • 99.57 (a)
NCAPD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncapd2 35
  • 85.66 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
Mammalia NCAPD2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPD2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPD2 35
  • 64.42 (n)
  • 63.46 (a)
NCAPD2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPD2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapd2 35
  • 63.39 (n)
  • 62.92 (a)
Str.6498 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398080 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26684 35
ncapd2 35
  • 56.58 (n)
  • 51.69 (a)
ncapd2 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003434 35
  • 45.28 (n)
  • 33.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CAP-D2 35
  • 44.86 (n)
  • 31.61 (a)
CAP-D2 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dpy-28 36
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR273C 35
  • 42.99 (n)
  • 30.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20119g 35
  • 41.89 (n)
  • 29.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCS4 35
  • 41.09 (n)
  • 29.42 (a)
YCS4 36
  • 25 (a)
OneToOne
YCS4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57060 35
  • 45.29 (n)
  • 33.3 (a)
rice
(Oryza sativa)
Liliopsida Os.9234 35
Os07g0659500 35
  • 46.36 (n)
  • 33.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4864 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09297 35
  • 45.82 (n)
  • 32.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnd1 35
  • 41.71 (n)
  • 29.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
Species with no ortholog for NCAPD2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPD2 Gene

ENSEMBL:
Gene Tree for NCAPD2 (if available)
TreeFam:
Gene Tree for NCAPD2 (if available)

Paralogs for NCAPD2 Gene

Pseudogenes.org Pseudogenes for NCAPD2 Gene

genes like me logo Genes that share paralogs with NCAPD2: view

No data available for Paralogs for NCAPD2 Gene

Variants for NCAPD2 Gene

Sequence variations from dbSNP and Humsavar for NCAPD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs733593 -- 6,527,226(+) ATGAC(A/G)AAACT intron-variant
rs740850 -- 6,528,950(-) ATTGC(A/G)TTGCC reference, synonymous-codon
rs740851 -- 6,529,184(-) AAGAA(A/G)AGGAA intron-variant
rs758739 -- 6,517,203(+) GGACT(C/G)TAATG intron-variant
rs917633 -- 6,502,798(+) acaca(A/G)caaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPD2 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
esv2407117 CNV Deletion 18987734
esv2745472 CNV Deletion 23290073
nsv8895 CNV Gain 18304495
esv2745473 CNV Deletion 23290073
esv2745476 CNV Deletion 23290073
nsv819436 CNV Loss 19587683

Relevant External Links for NCAPD2 Gene

HapMap Linkage Disequilibrium report
NCAPD2
Human Gene Mutation Database (HGMD)
NCAPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPD2 Gene

Disorders for NCAPD2 Gene

Relevant External Links for NCAPD2

Genetic Association Database (GAD)
NCAPD2
Human Genome Epidemiology (HuGE) Navigator
NCAPD2

No disorders were found for NCAPD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NCAPD2 Gene

Publications for NCAPD2 Gene

  1. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PMID: 10958694) Schmiesing J.A. … Yokomori K. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 3 4
  4. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. (PMID: 12138188) Ball A.R. Jr. … Yokomori K. (Mol. Cell. Biol. 2002) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for NCAPD2 Gene

Sources for NCAPD2 Gene

Back to Top

Content