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NCAPD2 Gene

protein-coding   GIFtS: 62
GCID: GC12P006602

Non-SMC Condensin I Complex, Subunit D2

  Search for NCAPD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Non-SMC Condensin I Complex, Subunit D21 2     XCAP-D2 Homolog2 3
CNAP12 3 5     KIAA01593 5
Chromosome Condensation Related SMC Associated Protein 11 2     CAP-D22
Chromosome Condensation-Related SMC-Associated Protein 12 3     Condensin Complex Subunit 12
Chromosome-Associated Protein D22 3     CAPD23
hCAP-D22 3     Non-SMC Condensin I Complex Subunit D23

External Ids:    HGNC: 243051   Entrez Gene: 99182   Ensembl: ENSG000000102927   OMIM: 6156385   UniProtKB: Q150213   

Export aliases for NCAPD2 gene to outside databases

Previous GC identifer: GC12P006473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NCAPD2 Gene:
NCAPD2 (non-SMC condensin I complex, subunit D2) is a protein-coding gene. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain

Gene Wiki entry for NCAPD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCAPD2 gene promoter:
         Elk-1   Pbx1a   CBF-C   GATA-1   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NCAPD2 promoter sequence
   Search Chromatin IP Primers for NCAPD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAPD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

NCAPD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAPD2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006602:  view genomic region     (about GC identifiers)

Start:
6,602,522 bp from pter      End:
6,641,132 bp from pter
Size:
38,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021 (See protein sequence)
Recommended Name: Condensin complex subunit 1  
Size: 1401 amino acids; 157182 Da
Subunit: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC
subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and
H3
Sequence caution: Sequence=BAA09930.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DUR4 Q8N6U3

Explore the universe of human proteins at neXtProt for NCAPD2: NX_Q15021

Explore proteomics data for NCAPD2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin
    complex and is required for chromosome condensation (By similarity)1
  • Ubiquitination2 at Lys35, Lys685, Lys749, Lys763, Lys855, Lys1065, Lys1110, Lys1209, Lys1288, Lys1301
  • Modification sites at PhosphoSitePlus

  • See NCAPD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055680.3  
    ENSEMBL proteins: 
     ENSP00000325017   ENSP00000444377   ENSP00000371895   ENSP00000438495   ENSP00000444417  
    Reactome Protein details: Q15021

    NCAPD2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NCAPD2

     
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    NCAPD2 Assay Products:

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    Search eBioscience for ELISAs for NCAPD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR007673 Condensin_cplx_su1
     IPR024324 Condensin_cplx_su1_N
     IPR026971 CND1/NCAPD3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q15021

    ProtoNet protein and cluster: Q15021

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CND1_HUMAN, Q15021
    Domain: The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex
    targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal,
    although they are contained within the same region
    Similarity: Belongs to the CND1 (condensin subunit 1) family


    Find genes that share domains with NCAPD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CND1_HUMAN, Q15021
    Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin
    into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
    relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
    presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12138188
    GO:0042393histone binding NAS10958694
         
    Find genes that share ontologies with NCAPD2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCAPD2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCAPD2
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    miRNA
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    miRTarBase miRNAs that target NCAPD2:
    hsa-mir-3620-3p (MIRT052865), hsa-mir-186-5p (MIRT045112), hsa-mir-155-5p (MIRT020820), hsa-mir-615-3p (MIRT039773), hsa-mir-484 (MIRT042024), hsa-mir-92b-3p (MIRT040571), hsa-mir-193b-3p (MIRT016499), hsa-let-7b-5p (MIRT051923), hsa-mir-93-3p (MIRT038733), hsa-mir-16-5p (MIRT031777), hsa-mir-331-3p (MIRT043407), hsa-mir-1303 (MIRT035874), hsa-mir-222-3p (MIRT046748)

    Block miRNA regulation of human, mouse, rat NCAPD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAPD2 (see all 10):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548l hsa-miR-664 hsa-miR-570 hsa-miR-646 hsa-miR-548t
    SwitchGear 3'UTR luciferase reporter plasmidNCAPD2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CND1_HUMAN, Q15021: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin
    complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation
    of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the
    condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the
    complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome
    condensation. Dissociation from chromosomes is observed in late telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228colocalizes with nuclear chromosome IDA12138188
    GO:0000793condensed chromosome IDA10101332
    GO:0000796condensin complex IDA11136719
    GO:0000797condensin core heterodimer NAS10958694
    GO:0005634nucleus NAS10958694

    Find genes that share ontologies with NCAPD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCAPD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    3Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase
    4Aurora B signaling
    Aurora B signaling


    Find genes that share SuperPaths with NCAPD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NCAPD2
        Cell cycle Chromosome condensation in prometaphase

    1 BioSystems Pathway for NCAPD2
        Aurora B signaling

    1 Reactome Pathway for NCAPD2
        Condensation of Prometaphase Chromosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCAPD2
    Interactions:

        Search GeneGlobe Interaction Network for NCAPD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCAPD2 (Q150211, 2, 3 ENSP000003250174) via UniProtKB, MINT, STRING, and/or I2D (see all 831)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC4Q9NTJ32, 3, ENSP000003413824MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000341382
    DNAJA1P316892, 3MINT-7945693 MINT-7947479 I2D: score=2 
    HSP90AA1P079002, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    TBL1XR1Q9BZK72, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006886intracellular protein transport ----
    GO:0007067mitosis ----
    GO:0007076mitotic chromosome condensation NAS10958694
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with NCAPD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCAPD2 (CND1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCAPD2 gene: 
    NM_014865.3  

    Unigene Cluster for NCAPD2:

    Non-SMC condensin I complex, subunit D2
    Hs.5719  [show with all ESTs]
    Unigene Representative Sequence: D63880
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541399 ENST00000315579(uc001qoo.2 uc010sfd.1) ENST00000539714
    ENST00000536538 ENST00000382457 ENST00000539084 ENST00000545732 ENST00000536090
    ENST00000542472 ENST00000538600 ENST00000542492 ENST00000535804 ENST00000539885
    ENST00000545962(uc009zen.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NCAPD2 (see all 10):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548l hsa-miR-664 hsa-miR-570 hsa-miR-646 hsa-miR-548t
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      QuantiFast Probe-based Assays in human, mouse, rat NCAPD2

    Additional mRNA sequence: 

    AK022511.1 AK125155.1 AK128354.1 AK303310.1 BC016913.1 BC028182.1 D63880.1 

    Selected DOTS entries (see all 25):

    DT.453564  DT.121201162  DT.99943013  DT.101974686  DT.121201133  DT.121201194  DT.92453084  DT.100704747 
    DT.101963266  DT.121201156  DT.121201200  DT.101971673  DT.95360020  DT.95360022  DT.99951776  DT.100652338 
    DT.121201159  DT.121201201  DT.91985744  DT.92443674  DT.95360002  DT.100685553  DT.100685554  DT.121201139 

    7 AceView cDNA sequences:

    AK128354 AK125155 D63880 AK022511 BC016913 BC028182 NM_014865 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                                            -     -                                                                                         -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:        -                                                                                                                                                   
    SP5:                                            -                                                                                                               

    ExUns: 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^
    SP1:                                                                                            -                       -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NCAPD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCAPD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NCAPD2 Expression
    About this image


    NCAPD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebral Cortex
    NCAPD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCAPD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5719
        Custom PCR Arrays for NCAPD2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NCAPD2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncapd21 , 5 non-SMC condensin I complex, subunit D21, 5 85.95(n)1
    86.76(a)1
      6 (59.32 cM)5
    682981  NM_146171.11  NP_666283.11 
     1251680075 
    chicken
    (Gallus gallus)
    Aves NCAPD21 non-SMC condensin I complex, subunit D2 64.42(n)
    63.46(a)
      418275  NM_001080862.1  NP_001074331.1 
    lizard
    (Anolis carolinensis)
    Reptilia NCAPD26
    non-SMC condensin I complex, subunit D2
    61(a)
    1 ↔ 1
    GL343381.1(569205-618091)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980802 13S condensin XCAP-D2 subunit 74.01(n)    AF072717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266842 Danio rerio cDNA clone IMAGE3817471, partial cds 72.65(n)    BC055262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAP-D21 CAP-D2 condensin subunit 44.86(n)
    31.61(a)
      43491  NM_143452.2  NP_651709.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-286
    Protein DPY-28 (dpy-28) mRNA, complete cds
    16(a)
    1 ↔ 1
    III(10763147-10777342) WBGene00001087
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCS4(YLR272C)4
    YCS41
    Subunit of the condensin complex; required for establishment more4
    YCS41
    41.09(n)1
    29.42(a)1
      12(687202-683672)4
    8509771, 4  NP_013374.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G570601 AT3G57060 45.29(n)
    33.3(a)
      824873  NM_115565.2  NP_191265.2 
    rice
    (Oryza sativa)
    Liliopsida Os.92342 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.43(n)    AK073537.1 


    ENSEMBL Gene Tree for NCAPD2 (if available)
    TreeFam Gene Tree for NCAPD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCAPD2 gene

    Find genes that share paralogs with NCAPD2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NCAPD2
    PGOHUM00000232646


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCAPD2 (see all 1020)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846751331,2
    --6604749(+) CCTGTA/TTTTGG 1 -- int10--------
    rs1396702861,2
    --6604796(+) TGGGGA/GCAAAA 1 -- int10--------
    rs1890358181,2
    --6604809(+) CCATAA/TTATAT 1 -- int10--------
    rs1497731661,2
    --6604811(+) ATAATA/GTATAT 1 -- int10--------
    rs1457342861,2
    --6604864(+) CTACTA/GAAACC 1 -- int10--------
    rs1418491401,2
    --6605000(+) GGCTGC/TCTGGA 1 -- int10--------
    rs1471231931,2
    --6605086(+) AAATAC/TAGAGA 1 -- int10--------
    rs1815534391,2
    --6605096(+) ATAATA/GACCAA 1 -- int10--------
    rs79607571,2
    C,F,A,H--6605105(+) AATTCC/ATTTGT 1 -- int129Minor allele frequency- A:0.37NS EA NA WA CSA 2775
    rs79753601,2
    C,F,A,H--6605155(+) CGACAA/GTATGG 1 -- int123Minor allele frequency- G:0.17NS EA NA CSA WA 2770

    HapMap Linkage Disequilibrium report for NCAPD2 (6602522 - 6641132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NCAPD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745476CNV Deletion23290073
    esv2407117CNV Deletion18987734
    esv2745473CNV Deletion23290073
    esv2745472CNV Deletion23290073
    nsv819436CNV Loss19587683
    nsv8895CNV Gain18304495
    esv34325CNV Gain17911159
    esv34390CNV Gain17911159
    essv12131CNV CNV17122850
    dgv453e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NCAPD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCAPD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NCAPD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615638    OMIM disorders: --


    Find genes that share disorders with NCAPD2           About GenesLikeMe

    Genetic Association Database (GAD): NCAPD2
    Human Genome Epidemiology (HuGE) Navigator: NCAPD2 (5 documents)

    Export disorders for NCAPD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCAPD2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with NCAPD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PubMed id 10958694)1, 2, 3, 9 Schmiesing J.A.... Yokomori K. (Mol. Cell. Biol. 2000)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469)1, 4 Lee J.H....Mayeux R. (Neurogenetics 2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. (PubMed id 12138188)1, 2 Ball A.R. Jr.... Yokomori K. (Mol. Cell. Biol. 2002)
    10. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)1, 2 Kimura K.... Hirano T. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9918 HGNC: 24305 AceView: CNAP1 Ensembl:ENSG00000010292 euGenes: HUgn9918
    ECgene: NCAPD2 H-InvDB: NCAPD2

    (According to HUGE)
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    HUGE: KIAA0159

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCAPD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCAPD2 gene:
    Search GeneIP for patents involving NCAPD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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